EP3682969B1 - Pipettenspitzen-adapter-baugruppe - Google Patents

Pipettenspitzen-adapter-baugruppe Download PDF

Info

Publication number
EP3682969B1
EP3682969B1 EP20159231.8A EP20159231A EP3682969B1 EP 3682969 B1 EP3682969 B1 EP 3682969B1 EP 20159231 A EP20159231 A EP 20159231A EP 3682969 B1 EP3682969 B1 EP 3682969B1
Authority
EP
European Patent Office
Prior art keywords
adapter
assembly
tubes
pipettor
sealing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20159231.8A
Other languages
English (en)
French (fr)
Other versions
EP3682969A1 (de
Inventor
Richard Cote
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avidien Technologies
Original Assignee
Avidien Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidien Technologies filed Critical Avidien Technologies
Publication of EP3682969A1 publication Critical patent/EP3682969A1/de
Application granted granted Critical
Publication of EP3682969B1 publication Critical patent/EP3682969B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/563—Joints or fittings; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
    • B01L3/5635—Joints or fittings; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors connecting two containers face to face, e.g. comprising a filter

Definitions

  • This invention relates generally to multichannel air displacement pipettors employing disposable pipette tips, and is concerned in the particular with the provision of an adapter for providing an interface between the pipette tips and the pipettor.
  • Air displacement pipettors are typically used to transfer liquids between vessels as part of an assay.
  • Common vessels are microtiter plates, test tubes and reservoirs.
  • Air displacement pipettors frequently make use of a piston and cylinder arrangement, which is used to create positive and negative pressure in an attached pipette tip. When the open end of the tip is placed into a liquid, the change in pressure causes the liquid to be aspirated into, or dispensed from, the interior of the pipette tip.
  • Cross contamination can occur when a first liquid sample aspirated into and then dispensed from a pipette tip leaves a residual amount of sample in the tip. A subsequently aspirated sample mixes with the residual first sample and is thus contaminated. This type of cross contamination can also occur through residual sample on the exterior of the pipette tip.
  • pipette tips are commonly injection molded in a chemically resistant material such as polypropylene. They are conical in shape.
  • the pipettor's mounting shaft is typically cylindrical with a slight taper that closely matches the conical angle and diameter of the tip.
  • the tip is installed by applying an axial force to the mounting shaft that forces the tapered portion of the shaft into the tip. Flexibility of the tip material allows it to stretch radially and provide both an air-tight seal and mechanical stability of the tip to the pipetting device.
  • the typical axial force required to securely mount a single tip onto a tip mounting shaft is between 1.5 and 4 lbs.
  • a stripper mechanism is typically used to push the tip from the mounting shaft. Tip ejection forces are in the same range as the mounting forces.
  • Pipette tips are frequently packaged in a rack that positions them with their top surfaces in a common plane with centerline spacing that matches that of the instrument. For example, a 96 channel pipette tip rack holds an 8 x 12 array of tips with 9mm between centers. The high forces required to attach all of the tips in the rack often causes the tip rack to bow in the center of the array, resulting in poor sealing and attachment of centrally located tips. To counter this, tip manufacturers reinforce the tip racks intended for use with multichannel pipettors. This, in turn, increases the cost of the racks and therefore the cost to operate the instrument.
  • the present invention is directed to an assembly comprising an adapter and an array of pipette tips, as defined by independent claim 1.
  • embodiments of the present invention address the drawbacks of the prior art by providing a pipette tip adapter whose purpose is to adapt commonly available low cost pipette tips to a multichannel air displacement pipettor in a way that reduces the mounting and ejection forces described above.
  • Any universal pipette tip available in the marketplace can be assembled to the pipette tip adapter.
  • End users of the related multichannel air displacement pipettor designed to accept the pipette tip adapter would install the assembly onto the pipettor.
  • the pipette tip adapter reduces the forces required to mount and seal the tips to less than 10 lbs. Ejection forces are equally reduced.
  • the tip mounting tubes are externally dimensioned and configured for insertion into the conical upper ends of pipette tips, and the sealing tubes are externally configured and dimensioned for insertion into ports of a multichannel air displacement pipettor.
  • the pipette tips comprise through bores with conical upper ends, and each of the tip mounting tubes of the adapter is engaged with one of the pipette tips.
  • the base may preferably be strengthened by networks of reinforcing ribs on its top and/or bottom surfaces.
  • a pipettor tip adapter as part of an assembly in accordance with an exemplary embodiment of the present invention is generally indicated at 10.
  • the pipette tip adapter comprises a planar base 12 with an array of openings 14 extending between bottom and top surface 16, 18 of the base.
  • Sealing tubes indicated typically at 20 project upwardly from the top surface 16, and tip mounting tubes indicated typically at 22 project downwardly from the bottom surface 18. Pairs of sealing tubes 20 and mounting tubes 22 are arranges coaxially and in communication with respective ones of the openings 14 in the base 12.
  • the sealing tubes 20 and tip mounting tubes 22 may be arranged in an array of rows and columns.
  • the spacing of the rows and columns matches the commonly available tip spacing of both multichannel pipettors and associated racks found in the marketplace. These in turn match the well positions of commonly available microtiter plates.
  • Nine and four and a half millimeters are two common spacing distances.
  • a 96 channel pipettor has twelve rows and eight columns of tips on nine millimeter spacing
  • a 384 channel pipettor has a twenty four by sixteen matrix on a four and a half millimeter spacing.
  • This invention can also be used in a one-dimensional array format. For example, a single row of twelve on a nine mm spacing.
  • the tip mounting tubes 22 comprise truncated conical cones configured and dimensioned for insertion and sealing interengagement with the conical upper ends 24 of pipette tips 26.
  • Fig. 5 shows an array of pipette tips 26 secured to the tip mounting tubes of the adapter.
  • Base 12 may be advantageously strengthened by a network of upper reinforcing ribs 28 on its top surface 16, and/or a similar network of lower reinforcing ribs 30 on its bottom surface 18.
  • the sealing tubes 20 may be located where the upper reinforcing ribs 28 converge, whereas the tip mounting tubes 22 may be located in areas of the bottom surface bracketed by the lower reinforcing ribs 30.
  • the sealing tubes 20 have cylindrical walls with chamfered upper ends 20a.
  • the tip mounting tubes 22 project downwardly below the lower reinforcing ribs 30, and the sealing tubes 20 project upwardly above the upper reinforcing ribs 28.
  • a multichannel air displacement pipettor is generally indicated at 32.
  • the head 34 of the pipettor is designed to accept the pipette adapter 10 of the present invention.
  • the pipette adapter may be provided with laterally extending rails 36 which are designed to slide into receiving slots in the pipettor head.
  • Tabs 35 also may be provided to facilitate handling the adapter.
  • the pipettor head has an array of cylinders indicated typically at 38 matching the array of sealing tubes 20 of the tip adapter 10.
  • the cylinders 38 lead to ports lined with O-rings providing compliant internal sealing surfaces.
  • O-rings 40 are shown, any equivalent compliant seal material and appropriate geometry could be employed.
  • a sheet of elastomeric material with a matrix of aligned bore holes could be employed.
  • the chamfered upper ends 20a of the sealing tubes serve to lower the insertion forces of the sealing tubes into the ports of the pipettor cylinders 38 while also reducing wear and tear of the O-rings 40 or other like compliant sealing surfaces.
  • Pistons indicated typically at 42 are arranged for reciprocal movement in the cylinders 38.
  • the pistons 42 are withdrawn in the cylinders 38 away from the adapter 10, and in Fig. 10 , the pistons are shown advanced in the cylinders.
  • the tip adapter 10 is preferably injection molded using standard tooling methods and common processing techniques.
  • Materials can include any rigid injection moldable polymer, with polypropylene being preferred.
  • a polymer with an internal lubricant that blooms to the surface of the part is preferable because the presence of the lubricant on the surface will reduce insertion forces and wear and tear on the seals.
  • the exemplary embodiment herein described is preferably disposable.
  • a non-disposable version is also possible, its design being essentially identical but produced from a material that is more robust and autoclavable. In such a design, the tips are installed to the adapter by the user with a dedicated fixture.
  • tip size geometries can be accommodated in a single adapter by arranging the tip mounting tubes in a tiered geometry, where the larger tips fit on one tier and the smaller tips on a second tier.
  • disposable pipette tips incorporate filters.
  • the purpose of the filter is to avoid aerosol contamination of the pipette mechanism by the liquid being pipetted.
  • the pipette tip adapter of the present invention may be configured to accept such filters, thereby eliminating the need to use expensive tips with filters pre-installed in them.
  • the adapter of the present invention offers significant and heretofore unavailable advantages.
  • the chamfered upper ends 20a of the sealing tubes 20 interact with the O-rings or equivalent compliant sealing materials to beneficially reduce the forces required to connect the pipette tips to the pipettor.
  • the adapter's sealing tubes 20 can be successfully inserted into the cylinder ports of the pipettor with a minimal coupling force on the order of 10lbs. This can be accomplished safely without exposing an operator to potential injury.
  • the adapter base 12 preferably when strengthened by the upper and/or lower reinforcing ribs 28, 30, provides a rigid platform supporting the tip mounting tubes 22 and sealing tubes 20.
  • the adapter can be pressed onto an array of pipette tubes without undergoing deflection that might otherwise compromise uniform and reliable sealed insertion of the tip mounting tubes 22.
  • This same rigidity when coupled with the minimal coupling forces referenced above, results in a more uniform and reliable insertion of the sealing tubes into the pipettor cylinder ports.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Claims (15)

  1. Anordnung, die einen Adapter (10) und ein Array von Pipettenspitzen (26) umfasst, wobei:
    der Adapter (10) eine ebene Basis (12) mit einem Array von Öffnungen (14), die sich zwischen Ober- und Unterseiten (16, 18) der Basis (12) erstrecken, Einschmelzröhrchen (20), die nach oben von der Oberseite (16) herausragen, und Spitzenanbringungsröhrchen (22), die nach unten von der Unterseite (18) herausragen, umfasst;
    Paare von Einschmelzröhrchen (20) und Spitzenanbringungsröhrchen (22) des Adapters (10) koaxial eingerichtet sind und mit entsprechenden Öffnungen (14) in der Basis (12) in Verbindung stehen;
    die Spitzenanbringungsröhrchen (22) extern bemessen und für eine Einsetzung in die konischen oberen Enden (24) der Pipettenspitzen (26) konfiguriert sind;
    die Einschmelzröhrchen (20) für die Einsetzung in Zugänge eines Mehrkanal-Mikropipettierers extern konfiguriert und bemessen sind;
    die Pipettenspitzen (26) durchgehende Bohrungen mit konischen oberen Enden (24) umfassen; und
    jedes der Spitzenanbringungsröhrchen (22) des Adapters (10) mit einer der Pipettenspitzen (26) in Eingriff steht.
  2. Anordnung nach Anspruch 1, wobei die Basis (12) mittels eines Netzwerks von oberen Versteifungsrippen (28) auf der Oberseite (16) verstärkt ist.
  3. Anordnung nach Anspruch 2, wobei die Einschmelzröhrchen (20) nach oben über die oberen Versteifungsrippen (28) herausragen.
  4. Anordnung nach einem der Ansprüche 1-3, wobei die Basis (12) mittels eines Netzwerks von unteren Versteifungsrippen (30) auf der Unterseite (18) verstärkt ist.
  5. Anordnung nach Anspruch 4, wobei die Spitzenanbringungsröhrchen (22) nach unten unter die unteren Versteifungsrippen (30) herausragen.
  6. Anordnung nach einem der Ansprüche 1-5, wobei die Spitzenanbringungsröhrchen (22) hohle Kegelstümpfe umfassen.
  7. Anordnung nach einem der Ansprüche 1-6, wobei die Einschmelzröhrchen (20) zylindrische Wände mit sich verjüngenden oberen Enden (20a) umfassen.
  8. Anordnung nach einem der Ansprüche 1-7, wobei der Adapter ein spritzgießbares Polymer umfasst.
  9. Anordnung nach einem der Ansprüche 1-8, wobei der Adapter Schienen (36), die sich seitlich erstrecken, beinhaltet.
  10. Anordnung nach einem der Ansprüche 1-9, wobei der Adapter Laschen (35) beinhaltet, um eine Handhabung des Adapters zu ermöglichen.
  11. Pipettiersystem, das die Anordnung nach einem der Ansprüche 1-10 und einen Mehrkanal-Mikropipettierer (32) umfasst, wobei die Einschmelzröhrchen (20) des Adapters (10) in Zugänge des Pipettierers (32) eingesetzt sind.
  12. Pipettiersystem nach Anspruch 11, wobei der Mehrkanal-Mikropipettierer (32) ein Array von Pipettierzylindern (38) beinhaltet.
  13. Pipettiersystem nach Anspruch 12, wobei der Mehrkanal-Mikropipettierer (32) ein Array von Kolben (42) umfasst, die für eine Hin- und Herbewegung in dem Array von Pipettierzylindern (38) eingerichtet sind.
  14. Pipettiersystem nach Anspruch 12 oder 13, wobei jeder Pipettierzylinder (38) des Mehrkanal-Mikropipettierers (32) ein nachgiebiges Einschmelzmaterial (40) umfasst.
  15. Pipettiersystem nach Anspruch 14, wobei das nachgiebige Einschmelzmaterial ein Array von O-Ringen (40) ist, die mit einer Außenseite jedes Einschmelzröhrchen (20) zusammenwirken.
EP20159231.8A 2011-07-20 2012-07-09 Pipettenspitzen-adapter-baugruppe Active EP3682969B1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161509577P 2011-07-20 2011-07-20
PCT/US2012/045925 WO2013012588A1 (en) 2011-07-20 2012-07-09 Pipette tip adapter
EP18184263.4A EP3412362B1 (de) 2011-07-20 2012-07-09 Verwendung eines pipettenspitzenadapters
EP12740432.5A EP2734301B1 (de) 2011-07-20 2012-07-09 Anpassungsteil zur verbindung von pipettenspitzen

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP18184263.4A Division EP3412362B1 (de) 2011-07-20 2012-07-09 Verwendung eines pipettenspitzenadapters
EP18184263.4A Division-Into EP3412362B1 (de) 2011-07-20 2012-07-09 Verwendung eines pipettenspitzenadapters
EP12740432.5A Division EP2734301B1 (de) 2011-07-20 2012-07-09 Anpassungsteil zur verbindung von pipettenspitzen

Publications (2)

Publication Number Publication Date
EP3682969A1 EP3682969A1 (de) 2020-07-22
EP3682969B1 true EP3682969B1 (de) 2022-03-23

Family

ID=46583015

Family Applications (3)

Application Number Title Priority Date Filing Date
EP20159231.8A Active EP3682969B1 (de) 2011-07-20 2012-07-09 Pipettenspitzen-adapter-baugruppe
EP18184263.4A Active EP3412362B1 (de) 2011-07-20 2012-07-09 Verwendung eines pipettenspitzenadapters
EP12740432.5A Active EP2734301B1 (de) 2011-07-20 2012-07-09 Anpassungsteil zur verbindung von pipettenspitzen

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP18184263.4A Active EP3412362B1 (de) 2011-07-20 2012-07-09 Verwendung eines pipettenspitzenadapters
EP12740432.5A Active EP2734301B1 (de) 2011-07-20 2012-07-09 Anpassungsteil zur verbindung von pipettenspitzen

Country Status (3)

Country Link
US (1) US20180117584A1 (de)
EP (3) EP3682969B1 (de)
WO (1) WO2013012588A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11559802B2 (en) 2011-07-20 2023-01-24 Avidien Technologies, Inc. Pipette tip adapter
WO2016081595A1 (en) * 2014-11-18 2016-05-26 Avidien Technologies Multichannel air displacement pipettor
DE102017117789A1 (de) * 2017-08-04 2019-02-07 Als Automated Lab Solutions Gmbh Adapter zur Aufnahme einer Kapillare und dessen Verwendung
EP3946738A2 (de) * 2019-03-27 2022-02-09 Avidien Technologies, Inc. Adapter für segmentierte pipettenspitzen
USD905267S1 (en) 2019-03-27 2020-12-15 Avidien Technologies, Inc. Pipette tip adapter
CN110813398A (zh) * 2019-11-18 2020-02-21 威尚生物技术（合肥）有限公司 一种移液器的枪头填装装置
WO2022174178A2 (en) * 2021-02-15 2022-08-18 University Of South Florida Systems and methods for dispensing liquids
DE102021107590A1 (de) 2021-03-25 2022-09-29 Heinrich-Heine-Universität Düsseldorf Vorrichtung zum effizienten Mediumwechsel in Mikrotiterplatten
USD1021135S1 (en) * 2022-05-31 2024-04-02 Tecan Trading Ag Tray for pipetting tips
EP4357023A1 (de) * 2022-10-21 2024-04-24 Tecan Trading AG Mehrkanal pipettierkopf

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI52025C (fi) * 1976-04-08 1977-06-10 Osmo Antero Suovaniemi Menetelmä ja laitteisto nesteannosteluun, nesteen siirtoon ja laimennu ssarjoihin.
US4237095A (en) * 1978-04-25 1980-12-02 Kommandiittiyhtio Finnpipette Osmo A. Suovaniemi Tip vessel for use in connection with a dosage pipette
US6159368A (en) * 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
FI20002761A0 (fi) * 2000-12-15 2000-12-15 Wallac Oy Monikanavainen pipetointilaitteisto
CA2440692A1 (en) * 2001-03-08 2002-09-19 Exelixis Inc. Multi-well apparatus
US7335337B1 (en) * 2001-09-11 2008-02-26 Smith James C Ergonomic pipette tip and adapters
US20040071602A1 (en) * 2002-10-15 2004-04-15 Yiu Felix H. Pipettor head adapter
US7185551B2 (en) * 2003-05-22 2007-03-06 Schwartz H Donald Pipetting module
EP3366333B1 (de) * 2009-07-15 2021-08-25 Becton Dickinson France Verpackungseinheit zum verpacken von länglichen objekten, insbesondere von spritzenkörper oder spritzen

Also Published As

Publication number Publication date
US20180117584A1 (en) 2018-05-03
EP2734301B1 (de) 2019-02-20
EP3412362A1 (de) 2018-12-12
EP2734301A1 (de) 2014-05-28
EP3682969A1 (de) 2020-07-22
WO2013012588A1 (en) 2013-01-24
EP3412362B1 (de) 2020-04-01

Similar Documents

Publication Publication Date Title
EP3682969B1 (de) Pipettenspitzen-adapter-baugruppe
US11559802B2 (en) Pipette tip adapter
US9084993B2 (en) Pipetting apparatus with a pipetting head comprising a multiplicity of pipetting channels disposed in an arrangement pattern
US9079178B2 (en) Apparatus and methods for pipetting with interchangeability among different pipette tips
US5827745A (en) Micropipette tip loading and unloading device and method and tip package
EP1074302B1 (de) Mehrkanal-Pipettensystem und Pipettenspitzen dafür
CN109416371B (zh) 计量头、包括计量头的计量装置和通过计量头进行计量的方法
US8117925B2 (en) Apparatus and method for using a tip collar on pipette tips providing structural rigidity
EP1110613A1 (de) Träger für Pipettenspitzen
CN113614542B (zh) 用于抽吸和/或分配液体的液体处理仪器和移液头以及方法
CN113396017A (zh) 移液头、包括移液头的移液装置和通过移液头进行移液的方法
US6550349B1 (en) Pipette tip holder
US9333499B2 (en) Pipetting apparatus
US7438862B2 (en) Apparatus for simultaneous processing of multiple samples
CN107405622A (zh) 管支架工具
US20170282188A1 (en) Apparatus and method for using a tip collar on a single row of pipette tips
EP4377014B1 (de) Mehrkanal pipettierkopf
US20170246624A1 (en) Pipette Tip Loading and Unloading Mechanism for Single Row Multichannel Pipettors
US20170282187A1 (en) Pipette Tips with Vertical Ribs
US20240230488A1 (en) High throughput vacuum extraction process
US20170120244A1 (en) Modular Well Plates
EP3974841A1 (de) Mehrkanalige pipettiervorrichtung
CN117225492A (zh) 操作移液系统的方法、移液系统、工具以及计算机实现的方法
WO2022258995A2 (en) Pipette tip for a liquid dispensing apparatus
CA3246684A1 (en) APPARATUS AND METHOD FOR TRANSFERRING AND DISTRIBUTING DRIED REAGENTS

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 2734301

Country of ref document: EP

Kind code of ref document: P

Ref document number: 3412362

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20201209

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIC1 Information provided on ipc code assigned before grant

Ipc: B01L 3/00 20060101ALN20210928BHEP

Ipc: B01L 3/02 20060101AFI20210928BHEP

INTG Intention to grant announced

Effective date: 20211021

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AC Divisional application: reference to earlier application

Ref document number: 2734301

Country of ref document: EP

Kind code of ref document: P

Ref document number: 3412362

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602012077922

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1477067

Country of ref document: AT

Kind code of ref document: T

Effective date: 20220415

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220623

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220623

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1477067

Country of ref document: AT

Kind code of ref document: T

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220624

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220725

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220723

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602012077922

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

26N No opposition filed

Effective date: 20230102

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20220731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220709

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220731

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220709

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20120709

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220323

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20250827

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20250827

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20250825

Year of fee payment: 14