EP3634450A4 - Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses - Google Patents

Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses Download PDF

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Publication number
EP3634450A4
EP3634450A4 EP18799088.2A EP18799088A EP3634450A4 EP 3634450 A4 EP3634450 A4 EP 3634450A4 EP 18799088 A EP18799088 A EP 18799088A EP 3634450 A4 EP3634450 A4 EP 3634450A4
Authority
EP
European Patent Office
Prior art keywords
app
viruses
dependence
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18799088.2A
Other languages
German (de)
French (fr)
Other versions
EP3634450A1 (en
Inventor
Luk H. VANDENBERGHE
Anna Claire MAURER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schepens Eye Research Institute Inc
Massachusetts Eye and Ear
Original Assignee
Massachusetts Eye and Ear Infirmary
Schepens Eye Research Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute Inc filed Critical Massachusetts Eye and Ear Infirmary
Priority claimed from PCT/US2018/032166 external-priority patent/WO2018209154A1/en
Publication of EP3634450A1 publication Critical patent/EP3634450A1/en
Publication of EP3634450A4 publication Critical patent/EP3634450A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP18799088.2A 2017-05-10 2018-05-10 Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses Pending EP3634450A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762504318P 2017-05-10 2017-05-10
PCT/US2018/032166 WO2018209154A1 (en) 2017-05-10 2018-05-10 Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses

Publications (2)

Publication Number Publication Date
EP3634450A1 EP3634450A1 (en) 2020-04-15
EP3634450A4 true EP3634450A4 (en) 2021-03-31

Family

ID=69547516

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18799088.2A Pending EP3634450A4 (en) 2017-05-10 2018-05-10 Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses

Country Status (2)

Country Link
EP (1) EP3634450A4 (en)
CN (1) CN110831611A (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6600624B2 (en) * 2013-05-31 2019-10-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Adeno-associated virus mutant and method of use thereof
EP3060575B1 (en) * 2013-10-11 2018-12-05 Massachusetts Eye & Ear Infirmary Methods of predicting ancestral virus sequences and uses thereof
GB201403684D0 (en) * 2014-03-03 2014-04-16 King S College London Vector

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 23 June 2016 (2016-06-23), ZINN ERIC: "Adeno-associated virus capsid protein", XP055774598, Database accession no. AKU89600 *
ERIC ZINN ET AL: "In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector", CELL REPORTS, vol. 12, no. 6, 1 August 2015 (2015-08-01), US, pages 1056 - 1068, XP055524241, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.07.019 *
M. NAUMER ET AL: "Properties of the Adeno-Associated Virus Assembly-Activating Protein", JOURNAL OF VIROLOGY, vol. 86, no. 23, 1 December 2012 (2012-12-01), US, pages 13038 - 13048, XP055372879, ISSN: 0022-538X, DOI: 10.1128/JVI.01675-12 *
MAURER ANNA C. ET AL: "The Assembly-Activating Protein Promotes Stability and Interactions between AAV's Viral Proteins to Nucleate Capsid Assembly", CELL REPORTS, vol. 23, no. 6, 8 May 2018 (2018-05-08), US, pages 1817 - 1830, XP055774488, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.04.026 *
See also references of WO2018209154A1 *

Also Published As

Publication number Publication date
EP3634450A1 (en) 2020-04-15
CN110831611A (en) 2020-02-21

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