EP3612170A4 - Procédé de fabrication d'un timbre transdermique de fentanyl avec distribution uniforme de cristaux de médicament - Google Patents

Procédé de fabrication d'un timbre transdermique de fentanyl avec distribution uniforme de cristaux de médicament Download PDF

Info

Publication number
EP3612170A4
EP3612170A4 EP18788597.5A EP18788597A EP3612170A4 EP 3612170 A4 EP3612170 A4 EP 3612170A4 EP 18788597 A EP18788597 A EP 18788597A EP 3612170 A4 EP3612170 A4 EP 3612170A4
Authority
EP
European Patent Office
Prior art keywords
making
drug crystal
crystal distribution
transdermal fentanyl
fentanyl patch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18788597.5A
Other languages
German (de)
English (en)
Other versions
EP3612170A1 (fr
Inventor
Spiros Fotinos
Jerome LANGLUME
Jean Paul CARAVITA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inep Europe Sarl
Original Assignee
Inep Europe Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/491,419 external-priority patent/US11052054B2/en
Priority claimed from US15/492,146 external-priority patent/US10377114B2/en
Priority claimed from US15/838,977 external-priority patent/US10391065B2/en
Priority claimed from US15/838,837 external-priority patent/US20180303764A1/en
Application filed by Inep Europe Sarl filed Critical Inep Europe Sarl
Publication of EP3612170A1 publication Critical patent/EP3612170A1/fr
Publication of EP3612170A4 publication Critical patent/EP3612170A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP18788597.5A 2017-04-19 2018-04-10 Procédé de fabrication d'un timbre transdermique de fentanyl avec distribution uniforme de cristaux de médicament Withdrawn EP3612170A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15/491,419 US11052054B2 (en) 2017-04-19 2017-04-19 Method for manufacturing a transdermal device
US15/492,146 US10377114B2 (en) 2017-04-20 2017-04-20 Method for making a transdermal fentanyl patch with even drug crystal distribution
US15/838,977 US10391065B2 (en) 2017-04-19 2017-12-12 Method for making a transdermal fentanyl patch with even drug crystal distribution
US15/838,837 US20180303764A1 (en) 2017-04-19 2017-12-12 Method for manufacturing a transdermal device
PCT/US2018/026802 WO2018194879A1 (fr) 2017-04-19 2018-04-10 Procédé de fabrication d'un timbre transdermique de fentanyl avec distribution uniforme de cristaux de médicament

Publications (2)

Publication Number Publication Date
EP3612170A1 EP3612170A1 (fr) 2020-02-26
EP3612170A4 true EP3612170A4 (fr) 2021-01-27

Family

ID=63856066

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18788597.5A Withdrawn EP3612170A4 (fr) 2017-04-19 2018-04-10 Procédé de fabrication d'un timbre transdermique de fentanyl avec distribution uniforme de cristaux de médicament

Country Status (2)

Country Link
EP (1) EP3612170A4 (fr)
WO (1) WO2018194879A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060078600A1 (en) * 2003-02-07 2006-04-13 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof
US20110111013A1 (en) * 2008-04-25 2011-05-12 Acino Ag Transdermal therapeutic system for administration of fentanyl or an analogue thereof
US20120209223A1 (en) * 2009-09-14 2012-08-16 Acino Ag Transdermal therapeutic system for administration of fentanyl or an analog thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365178B1 (en) * 1996-09-06 2002-04-02 Watson Pharmaceuticals, Inc. Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions
US20010033858A1 (en) * 2000-02-29 2001-10-25 Jie Zhang Transdermal drug patch
US20040086551A1 (en) * 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
AR095259A1 (es) * 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria
EP3267982A4 (fr) * 2015-03-13 2018-11-07 Amneal Pharmaceuticals LLC Système d'administration transdermique de fentanyl

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060078600A1 (en) * 2003-02-07 2006-04-13 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof
US20110111013A1 (en) * 2008-04-25 2011-05-12 Acino Ag Transdermal therapeutic system for administration of fentanyl or an analogue thereof
US20120209223A1 (en) * 2009-09-14 2012-08-16 Acino Ag Transdermal therapeutic system for administration of fentanyl or an analog thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2018194879A1 *

Also Published As

Publication number Publication date
WO2018194879A1 (fr) 2018-10-25
EP3612170A1 (fr) 2020-02-26

Similar Documents

Publication Publication Date Title
EP2995343A4 (fr) Méthode de production de timbre transdermique et timbre transdermique
EP3235538A4 (fr) Timbre à micro-aiguilles, son procédé de fabrication et appareil pour la fabrication d'un réseau de micro-aiguilles
EP3826708A4 (fr) Timbre à micro-aiguilles pour injections transdermiques
EP3329914A4 (fr) Procédé de fabrication d'un timbre contenant de l'asénapine
EP3258895A4 (fr) Dispositif de régulateur pour patch médicamenté
EP3138431A4 (fr) Tige de chaussure et procédé pour tricoter une tige de chaussure
EP3613465A4 (fr) Timbre transdermique pour tissu biologique
EP3127569A4 (fr) Dispositif d'injection de médicament, procédé de commande d'affichage pour dispositif d'injection de médicament, et dispositif d'affichage de site d'injection
EP3292089A4 (fr) Système et procédé de fabrication et d'application de matériau à base de ciment non portland
EP3123889A4 (fr) Empeigne de chaussure et procédé de tricotage d'empeigne de chaussure
EP3795206A4 (fr) Timbre transdermique de diffusion de médicament et son procédé de préparation
EP3416718A4 (fr) Dispositif de régulation pour patch médicamenteux
EP3216482A4 (fr) Dispositif d'administration transdermique et procédé de fabrication de dispositif d'administration transdermique
GB201600920D0 (en) Transdermal patch
EP3399579A4 (fr) Procédé de préparation de matière active d'électrode positive et matière active d'électrode positive ainsi préparée
EP3745898A4 (fr) Système et procédé de stabilisation de chaussures
EP3103849A4 (fr) Agent adhésif dermatologique, matériau de timbre transdermique et procédé pour la production d'agent adhésif dermatologique
EP3241837A4 (fr) Procédé de préparation de la forme cristalline-6 du sofosbuvir
EP3145112A4 (fr) Procédé et dispositif de compensation de décalage de phase
EP3234261A4 (fr) Procédé d'application de matériau de papier peint
EP3337397A4 (fr) Système et procédé pour timbre de biocapteur et d'administration de médicament
EP3795205C0 (fr) Procédé de fabrication d'un timbre transdermique de diffusion de médicament
EP3267982A4 (fr) Système d'administration transdermique de fentanyl
EP3638216A4 (fr) Film de conditionnement de patch transdermique
EP3612170A4 (fr) Procédé de fabrication d'un timbre transdermique de fentanyl avec distribution uniforme de cristaux de médicament

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20191119

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20210113

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/70 20060101AFI20201222BHEP

Ipc: A61K 31/4535 20060101ALI20201222BHEP

Ipc: A61K 31/4468 20060101ALI20201222BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20231101