EP3601565A4 - Mir-92-inhibitoren zur behandlung von herzinsuffizienz - Google Patents
Mir-92-inhibitoren zur behandlung von herzinsuffizienz Download PDFInfo
- Publication number
- EP3601565A4 EP3601565A4 EP18777343.7A EP18777343A EP3601565A4 EP 3601565 A4 EP3601565 A4 EP 3601565A4 EP 18777343 A EP18777343 A EP 18777343A EP 3601565 A4 EP3601565 A4 EP 3601565A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- mir
- inhibitors
- treatment
- heart failure
- heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762476780P | 2017-03-25 | 2017-03-25 | |
US201762477385P | 2017-03-27 | 2017-03-27 | |
PCT/US2018/024167 WO2018183127A1 (en) | 2017-03-25 | 2018-03-23 | Mir-92 inhibitors for treatment of heart failure |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3601565A1 EP3601565A1 (de) | 2020-02-05 |
EP3601565A4 true EP3601565A4 (de) | 2021-01-06 |
Family
ID=63676655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18777343.7A Withdrawn EP3601565A4 (de) | 2017-03-25 | 2018-03-23 | Mir-92-inhibitoren zur behandlung von herzinsuffizienz |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP3601565A4 (de) |
WO (1) | WO2018183127A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201791644A1 (ru) | 2015-01-20 | 2018-01-31 | Мираджен Терапьютикс, Инк. | Ингибиторы mir-92 и их применение |
EP4269586A1 (de) | 2022-04-29 | 2023-11-01 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | Targeting von mikro-rna zur behandlung von herzversagen mit konservierter ejektionsfraktion (hfpef) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014115103A1 (en) * | 2013-01-24 | 2014-07-31 | Pierre Fabre Medicament S.A.S. | Composition comprising an encapsulated antagomir |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110086348A1 (en) * | 2009-02-19 | 2011-04-14 | The Cleveland Clinic Foundation | Method for assessing heart disease |
CN102481310A (zh) * | 2009-05-20 | 2012-05-30 | 得克萨斯系统大学董事会 | 牵涉心肌梗死后重塑和心力衰竭的微小rna的鉴定 |
CN104685056A (zh) * | 2012-06-21 | 2015-06-03 | 米拉根医疗股份有限公司 | 包含锁核酸基序的基于寡核苷酸的抑制剂 |
WO2015066611A2 (en) * | 2013-11-01 | 2015-05-07 | The Trustees Of Columbia University In The City Of New York | Microrna profiles in heart failure: methods and systems for detection and use |
-
2018
- 2018-03-23 WO PCT/US2018/024167 patent/WO2018183127A1/en unknown
- 2018-03-23 EP EP18777343.7A patent/EP3601565A4/de not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014115103A1 (en) * | 2013-01-24 | 2014-07-31 | Pierre Fabre Medicament S.A.S. | Composition comprising an encapsulated antagomir |
Non-Patent Citations (4)
Title |
---|
FUJITA MASANORI ET AL: "Inhibition of MicroRNA-92a Enhances Angiogenesis and Cardiomyocyte Regeneration Through Integrin a5-Dependent Accumulation of Stem Cells Into the Infarcted Myocardium", CIRCULATION, vol. 124, no. 21, Suppl. S, November 2011 (2011-11-01), & SCIENTIFIC SESSIONS OF THE AMERICAN-HEART-ASSOCIATION/RESUSCITATION SCIENCE SYMPOSIUM; ORLANDO, FL, USA; NOVEMBER 12 -16, 2011, pages A12590, XP002800953 * |
R. HINKEL ET AL: "Inhibition of MicroRNA-92a Protects Against Ischemia/Reperfusion Injury in a Large-Animal Model", CIRCULATION, vol. 128, no. 10, 3 September 2013 (2013-09-03), US, pages 1066 - 1075, XP055375248, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.113.001904 * |
See also references of WO2018183127A1 * |
XINYU LIU ET AL: "Role of microRNAs in the pathogenesis of diabetic cardiomyopathy", BIOMEDICAL REPORTS MAY 2014 SPANDIDOS PUBLICATIONS GBR, vol. 6, no. 2, 12 January 2017 (2017-01-12), Greece, pages 140 - 145, XP055749498, ISSN: 2049-9434, DOI: 10.3892/br.2017.841 * |
Also Published As
Publication number | Publication date |
---|---|
EP3601565A1 (de) | 2020-02-05 |
WO2018183127A1 (en) | 2018-10-04 |
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Legal Events
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
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Effective date: 20191023 |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20201207 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/113 20100101ALI20201130BHEP Ipc: C12N 15/11 20060101AFI20201130BHEP Ipc: A61K 31/712 20060101ALI20201130BHEP Ipc: A61P 9/10 20060101ALN20201130BHEP |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20210722 |