EP3600319A4 - Nouvel acide alpha-hydroxy carboxylique et dérivés et autres promédicaments d'opioïdes à base de gras et leurs utilisations - Google Patents

Nouvel acide alpha-hydroxy carboxylique et dérivés et autres promédicaments d'opioïdes à base de gras et leurs utilisations Download PDF

Info

Publication number
EP3600319A4
EP3600319A4 EP18774382.8A EP18774382A EP3600319A4 EP 3600319 A4 EP3600319 A4 EP 3600319A4 EP 18774382 A EP18774382 A EP 18774382A EP 3600319 A4 EP3600319 A4 EP 3600319A4
Authority
EP
European Patent Office
Prior art keywords
gras
opioids
derivatives
carboxylic acid
hydroxy carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18774382.8A
Other languages
German (de)
English (en)
Other versions
EP3600319A1 (fr
Inventor
John K. Thottathil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/472,758 external-priority patent/US10449190B2/en
Application filed by Individual filed Critical Individual
Publication of EP3600319A1 publication Critical patent/EP3600319A1/fr
Publication of EP3600319A4 publication Critical patent/EP3600319A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Addiction (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP18774382.8A 2017-03-29 2018-03-27 Nouvel acide alpha-hydroxy carboxylique et dérivés et autres promédicaments d'opioïdes à base de gras et leurs utilisations Withdrawn EP3600319A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/472,758 US10449190B2 (en) 2015-04-27 2017-03-29 Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof
PCT/US2018/024476 WO2018183264A1 (fr) 2017-03-29 2018-03-27 Nouvel acide alpha-hydroxy carboxylique et dérivés et autres promédicaments d'opioïdes à base de gras et leurs utilisations

Publications (2)

Publication Number Publication Date
EP3600319A1 EP3600319A1 (fr) 2020-02-05
EP3600319A4 true EP3600319A4 (fr) 2020-11-25

Family

ID=63676908

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18774382.8A Withdrawn EP3600319A4 (fr) 2017-03-29 2018-03-27 Nouvel acide alpha-hydroxy carboxylique et dérivés et autres promédicaments d'opioïdes à base de gras et leurs utilisations

Country Status (2)

Country Link
EP (1) EP3600319A4 (fr)
WO (1) WO2018183264A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3226855A1 (fr) * 2014-12-01 2017-10-11 Cellix Bio Private Limited Compositions et méthodes pour le traitement de la sclérose en plaques
US10226456B2 (en) 2015-04-27 2019-03-12 3St Research Llc Methods and compositions for preventing opioid abuse
EP4200275A2 (fr) 2020-08-21 2023-06-28 Sitryx Therapeutics Limited Nouveaux composés

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002995A1 (fr) * 2009-07-02 2011-01-06 Kempharm, Inc. Conjugués d'acide phényléthanoïque, d'acide phénylpropanoïque et d'acide phénylpropénoïque et promédicaments d'hydrocodone, leurs procédés de fabrication et d'utilisation
US20160326182A1 (en) * 2015-04-27 2016-11-10 Waterville Valley Technologies, Inc. Methods and compositions for preventing opioid abuse

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
CN1263760C (zh) * 2002-11-12 2006-07-12 财团法人奇美医院 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物
KR101598138B1 (ko) * 2008-04-24 2016-02-29 얀센 파마슈티카 엔.브이. 날메펜 디에스테르 프로드럭
CN102573845A (zh) * 2009-04-02 2012-07-11 夏尔有限责任公司 新的阿片样物质的二羧酸连接的氨基酸和肽前药及其用途
US10449190B2 (en) * 2015-04-27 2019-10-22 John K. Thottathil Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002995A1 (fr) * 2009-07-02 2011-01-06 Kempharm, Inc. Conjugués d'acide phényléthanoïque, d'acide phénylpropanoïque et d'acide phénylpropénoïque et promédicaments d'hydrocodone, leurs procédés de fabrication et d'utilisation
US20160326182A1 (en) * 2015-04-27 2016-11-10 Waterville Valley Technologies, Inc. Methods and compositions for preventing opioid abuse

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2018183264A1 *
SZABOLCS BÉNI ET AL: "Preparation of benzoate esters of morphine and its derivatives", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 143, no. 10, 26 June 2012 (2012-06-26), pages 1431 - 1440, XP035116687, ISSN: 1434-4475, DOI: 10.1007/S00706-012-0803-8 *

Also Published As

Publication number Publication date
EP3600319A1 (fr) 2020-02-05
WO2018183264A1 (fr) 2018-10-04

Similar Documents

Publication Publication Date Title
EP3541932A4 (fr) Inhibiteurs de crispr-cas9
EP3380098A4 (fr) Nouvel acide alpha-hydroxy carboxylique et dérivés et autres promédicaments à base de gras d'oxycodone et leurs utilisations
EP3681854A4 (fr) Formation d'esters d'acide téréphtalique
EP3288958A4 (fr) Compositions d'acide obéticholique et procédés d'utilisation
EP3234027A4 (fr) Composition aqueuse de revêtement et son procédé de fabrication
EP3292116B8 (fr) Acides 3-aryl-4-amido-bicyclo [4,5,0]hydroxamiques en tant qu'inhibiteurs de hdac
EP3331530A4 (fr) Inhibiteurs de mthfd2 et utilisation desdits inhibiteurs
EP3473614A4 (fr) Composé ester d'acide sulfonique et son utilisation
EP3145505A4 (fr) Inhibiteurs d'amidase acide (naaa) hydrolysant la n-acyléthanolamine et leur utilisation
EP3558303A4 (fr) Composés acides aminés et leurs procédés d'utilisation
EP3563853A4 (fr) Composition d'acide dicarboxylique mannuronique
EP3555076A4 (fr) Nouveaux dérivés de l'acide phényl propionique et leurs utilisations
EP3532633A4 (fr) Compositions et procédés pour la production de composés
EP3094718A4 (fr) Micro-organismes pour la production améliorée d'amino-acides et procédés associés
EP3473613A4 (fr) Composé d'ester d'acide sulfonique et son utilisation
EP3529232A4 (fr) Dérivés d'acide sulfamique et procédés pour leur préparation
EP3615515A4 (fr) Dérivés d'acide propionique et méthodes d'utilisation associées
EP3713920A4 (fr) Dérivés d'acide oxoacridinyle acétique et procédés d'utilisation
EP3211040A4 (fr) Ester d'acide polyaspartique modifié et composition de résine durcissable
EP3660023A4 (fr) Composé utilisé en tant qu'inhibiteur d'acc et utilisation associée
EP3234046A4 (fr) Composition de revêtement aqueuse et procédé pour la fabriquer
EP3615514A4 (fr) Dérivés d'acide propionique et leurs procédés d'utilisation
EP3458448A4 (fr) Procédés d'utilisation d'inhibiteurs de fasn
EP3655409A4 (fr) Nouveaux composés et leurs utilisations en tant qu'inhibiteurs acc
EP3149099A4 (fr) Compositions d'acide synthétique et leurs utilisation

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20190924

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 489/04 20060101ALI20200710BHEP

Ipc: A61P 25/36 20060101ALI20200710BHEP

Ipc: C07D 489/08 20060101ALI20200710BHEP

Ipc: A61K 31/485 20060101ALI20200710BHEP

Ipc: C07D 489/02 20060101AFI20200710BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20201027

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 489/04 20060101ALI20201021BHEP

Ipc: C07D 489/02 20060101AFI20201021BHEP

Ipc: A61P 25/36 20060101ALI20201021BHEP

Ipc: C07D 489/08 20060101ALI20201021BHEP

Ipc: A61K 31/485 20060101ALI20201021BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20210526