EP3600319A4 - Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof - Google Patents
Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof Download PDFInfo
- Publication number
- EP3600319A4 EP3600319A4 EP18774382.8A EP18774382A EP3600319A4 EP 3600319 A4 EP3600319 A4 EP 3600319A4 EP 18774382 A EP18774382 A EP 18774382A EP 3600319 A4 EP3600319 A4 EP 3600319A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gras
- opioids
- derivatives
- carboxylic acid
- hydroxy carboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Addiction (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/472,758 US10449190B2 (en) | 2015-04-27 | 2017-03-29 | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
PCT/US2018/024476 WO2018183264A1 (en) | 2017-03-29 | 2018-03-27 | Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3600319A1 EP3600319A1 (en) | 2020-02-05 |
EP3600319A4 true EP3600319A4 (en) | 2020-11-25 |
Family
ID=63676908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18774382.8A Withdrawn EP3600319A4 (en) | 2017-03-29 | 2018-03-27 | Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP3600319A4 (en) |
WO (1) | WO2018183264A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107207411A (en) * | 2014-12-01 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | composition and method for treating multiple sclerosis |
US10226456B2 (en) | 2015-04-27 | 2019-03-12 | 3St Research Llc | Methods and compositions for preventing opioid abuse |
EP4200275A2 (en) | 2020-08-21 | 2023-06-28 | Sitryx Therapeutics Limited | Fumarate derivatives and their medical use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011002995A1 (en) * | 2009-07-02 | 2011-01-06 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
US20160326182A1 (en) * | 2015-04-27 | 2016-11-10 | Waterville Valley Technologies, Inc. | Methods and compositions for preventing opioid abuse |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040058946A1 (en) * | 2002-07-05 | 2004-03-25 | Buchwald Stephen L. | Abuse-resistant prodrugs of oxycodone and other pharmaceuticals |
CN1263760C (en) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | Novel buprenorphine ester derivatives and process for preparing the same and medical compounds with long-acting analgesic effect |
PL2307420T3 (en) * | 2008-04-24 | 2012-04-30 | Janssen Pharmaceutica Nv | Nalmefene di-ester prodrugs |
EP2413937A1 (en) * | 2009-04-02 | 2012-02-08 | Shire LLC | Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof |
US10449190B2 (en) * | 2015-04-27 | 2019-10-22 | John K. Thottathil | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
-
2018
- 2018-03-27 WO PCT/US2018/024476 patent/WO2018183264A1/en unknown
- 2018-03-27 EP EP18774382.8A patent/EP3600319A4/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011002995A1 (en) * | 2009-07-02 | 2011-01-06 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
US20160326182A1 (en) * | 2015-04-27 | 2016-11-10 | Waterville Valley Technologies, Inc. | Methods and compositions for preventing opioid abuse |
Non-Patent Citations (2)
Title |
---|
See also references of WO2018183264A1 * |
SZABOLCS BÉNI ET AL: "Preparation of benzoate esters of morphine and its derivatives", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 143, no. 10, 26 June 2012 (2012-06-26), pages 1431 - 1440, XP035116687, ISSN: 1434-4475, DOI: 10.1007/S00706-012-0803-8 * |
Also Published As
Publication number | Publication date |
---|---|
EP3600319A1 (en) | 2020-02-05 |
WO2018183264A1 (en) | 2018-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20190924 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 489/04 20060101ALI20200710BHEP Ipc: A61P 25/36 20060101ALI20200710BHEP Ipc: C07D 489/08 20060101ALI20200710BHEP Ipc: A61K 31/485 20060101ALI20200710BHEP Ipc: C07D 489/02 20060101AFI20200710BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20201027 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 489/04 20060101ALI20201021BHEP Ipc: C07D 489/02 20060101AFI20201021BHEP Ipc: A61P 25/36 20060101ALI20201021BHEP Ipc: C07D 489/08 20060101ALI20201021BHEP Ipc: A61K 31/485 20060101ALI20201021BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20210526 |