EP3599188B1 - Blister package for medical products and tool for producing the blister package - Google Patents
Blister package for medical products and tool for producing the blister package Download PDFInfo
- Publication number
- EP3599188B1 EP3599188B1 EP18185814.3A EP18185814A EP3599188B1 EP 3599188 B1 EP3599188 B1 EP 3599188B1 EP 18185814 A EP18185814 A EP 18185814A EP 3599188 B1 EP3599188 B1 EP 3599188B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- recess
- blister
- strip
- active material
- blister package
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940127554 medical product Drugs 0.000 title description 26
- 239000011149 active material Substances 0.000 claims description 61
- 239000000463 material Substances 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 229940126601 medicinal product Drugs 0.000 claims 5
- 230000002093 peripheral effect Effects 0.000 claims 2
- 238000007789 sealing Methods 0.000 description 43
- 239000010408 film Substances 0.000 description 30
- 239000013039 cover film Substances 0.000 description 26
- 238000000465 moulding Methods 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000003826 tablet Substances 0.000 description 5
- 238000013461 design Methods 0.000 description 4
- 239000008298 dragée Substances 0.000 description 4
- 239000011888 foil Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 229920004439 Aclar® Polymers 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B17/00—Other machines, apparatus, or methods for packaging articles or materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B47/00—Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved
- B65B47/04—Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved by application of mechanical pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
- B65D81/268—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being enclosed in a small pack, e.g. bag, included in the package
Definitions
- the invention relates to a blister pack for medical products, in particular tablets, capsules or dragees, and a tool for producing the blister pack.
- Blister packs for medical products usually consist of a bottom foil, into which a plurality of blister cups are molded, which are filled with medical products, and a cover foil.
- the cover film is sealed onto the bottom film and thus closes the blister bowls so that the medical products can be stored in the blister bowl in a protected manner.
- inserts made of active material are usually placed in a chamber connected to the blister cup before the blister cup is sealed with the cover film.
- the WO2018 / 145099 is a document that falls under Art. 54 (3) EPC and discloses, like the WO2011 / 052422 such a blister pack with inserted active material.
- the US2002 / 112449 discloses a package with a blister cup which has a two-stage construction. Of the EP2511075 a process for the production of a two-stage or multi-stage blister cup can be found.
- Such blister packs have increased space requirements due to the additional inserts made of active material.
- the inserts made of active material have to be introduced into relatively complex shaped chambers of the blister cups so that they do not fall out of the blister cup when the user pushes out the blister cup and can be inadvertently taken with it. This makes the manufacturing process more difficult.
- the blister pack according to the invention for medical products comprises a base film in which at least one blister cup is formed, which is surrounded by webs of the base film.
- the at least one blister cup has an at least two-step shape such that it has a first recess which defines a first step of the blister cup and a second recess which is arranged in a section of a surface area spanned by the first recess and is lower than the first recess.
- a cover film covers the at least one blister cup and is sealed to webs of the base film.
- a strip of active material is arranged in the at least one blister cup and sealed to the cover film.
- the medical product is received in the second recess and the strip of active material is received in the first recess.
- the first recess has a circumferential rib in a bottom area that runs around the second recess, or at least two protruding knobs that are arranged next to the second recess, the strip of active material resting on the rib or knobs.
- the blister pack can be produced in a simple manner, impresses with a secure connection between the strip of active material and the cover film in the area of the sealing points and guarantees error-free handling by the user.
- the rib or the knobs are preferably formed in one piece with the bottom foil. In this way, the construction of the blister pack is made as simple as possible. Another advantage is that the rib or the knobs can be molded into the base film at the same time as the blister cups during the manufacturing process.
- the rib or the knobs have a rounding at the apex or a flat plateau surface. This forms a suitable support surface for the strip of active material which, during the sealing process, exerts a counterforce to the upper sealing tool on the strip of active material and the cover film.
- the contact surface for the strips of active material is preferably relatively small, so that the counter-pressure achieved by the rib or the knobs is exerted over a relatively small area, whereby the connection between the cover film and the strip of active material is particularly pronounced in the area of the sealing point .
- the strip is a film section and has a thickness of 0.2 mm to 2 mm, more preferably 0.3 mm to 1.2 mm.
- a relatively small thickness is advantageous in terms of reducing the space requirement, but is at the same time thick enough to ensure reliable handling of the strips during the manufacturing process.
- the rib or the knobs advantageously have a height of between 0.5 mm and 5 mm, preferably between 1 mm and 3 mm. This creates a sufficient distance between the medical product and the strip of active material.
- the active material due to its material properties, has an absorption function for absorbing at least one substance or a release function for releasing at least one substance. In this way, depending on the requirements of the medical product, the integrity of the product can be guaranteed over a long period of time.
- exactly two knobs are provided, which are arranged on opposite sides of the second recess.
- the connection between the strip of active material and the cover film is limited to the minimum of exactly two sealing points. These two sealing points are particularly durable.
- the strip of active material is arranged transversely to the medical product.
- the strip of active material has a recess which is arranged above the medical product. In this way, the medical product can be pressed out of the blister cup through the recess.
- the tool according to the invention for producing a blister pack for medical products, in particular tablets, capsules or dragees comprises at least one depression for forming or receiving at least one blister cup of the blister pack.
- the at least one trough has an at least two-step shape such that it has a first Has recess which defines a first step of the trough, and has a second recess which is arranged in a section of a surface area spanned by the first recess and is lower than the first recess.
- the first recess has a protruding circumferential projection in a bottom area, which extends around the second recess, or at least two spaced apart protruding projections that are arranged next to the second recess, or at least one protruding displaceable support element that extends around the second recess extends, or at least two spaced apart protruding sliding pins, which are arranged next to the second recess on.
- the shape of a blister pack according to the invention can be produced in a simple and safe manner.
- This embodiment relates on the one hand to a molding tool for forming a corresponding contour of the blister cups, and on the other to a sealing tool in which the sealing between the cover film and the strips of active material is particularly reliable at predefined sealing points.
- the projection or the projections or the support element or the pins have a rounding or a flat plateau surface at the apex or at the tip.
- the projections are of the same height and have a height of 0.5 mm to 5 mm, more preferably 1 mm to 3 mm.
- the blister pack 2 comprises a base film 6, in which at least one blister cup 8 is molded, which is surrounded by webs 10 of the base film 6.
- the in Fig. 1 The illustrated section of the blister pack 2 shows only one blister cup 8.
- blister packs 2 have a plurality of blister cups 8, which are usually distributed over the blister pack 2 in a regular pattern.
- a frequently used arrangement of the blister cups 8 in the blister pack 2 is a matrix of rows and columns.
- a cover film 12 which covers the at least one blister cup 8, is sealed to the webs 10 of the bottom film 6 and closes the at least one blister cup 8.
- the cover film 12 is only in Fig. 3 shown while in Fig. 1 and 2 has been omitted for the sake of clarity.
- PVC, PVDC, Aclar, aluminum, PETG or composite films are particularly suitable as the material for the floor film.
- Particularly suitable materials for the cover film are aluminum, polyethylene, polypropylene, paper-laminated and other composite films.
- a strip 14 of active material is arranged in at least one blister cup 8 and sealed to the cover film 12.
- the sealing with the cover film 12 can be over the entire surface, only over certain surface areas of the strip 14, along lines or also only selectively.
- the active material Due to its material properties, the active material generally has an intake function for absorbing at least one substance or a release function for releasing at least one substance. The most common use is to absorb moisture. In the case of strips 14 with an absorbing function, the strips 14 made of active material can also absorb oxygen, CO 2 , reactive contaminants or odors, for example. In the case of strips 14 with a release function, the strips 14 made of active material can release nitrogen or carbon dioxide, for example.
- a strip 14 of active material preferably has a thickness of 0.2 mm to 2 mm, more preferably 0.3 mm to 1.2 mm.
- the material of the strip 14 is preferably at least a little flexurally stiff in order to simplify handling.
- the material of the strip 14 is preferably a film, more preferably a polymer, particularly preferably a three-phase polymer.
- the film can be produced, for example, by extrusion, the active particles being added to the polymer. Channels within the polymer allow gases to move.
- the active particles are preferably present as spheres in the strip 14 made of active material.
- the product 4 is designed as an oblong and the strip 14 of active material has a substantially rectangular base area.
- the strip 14 is arranged transversely to the product 4, preferably at an angle of approximately 45 °. Usual dimensions of the strip 14 in the longitudinal and transverse directions are approximately 5 mm to 50 mm.
- each blister cup 8 comprises a two-step shape, in which a first recess 16 defines a first step of the blister cup 8.
- a second recess 18 is arranged in a partial section of the surface area spanned by the first recess 16 and is lower than the first recess 16.
- the medical product 4 is received in the second recess 18, while the strip 14 of active material is received in the first recess 16 is.
- the strip 14 made of active material rests on contact surfaces 20 of the first recess 16, which are arranged next to the second recess 18.
- the strip 14 and the product 4 are thus preferably spaced apart from one another in the vertical direction.
- the two bearing surfaces 20 for the strip 14 made of active material are diametrically opposite one another on two sides of the second recess 18.
- the strip 14 made of active material thus covers a large part of the second recess 18 and rests with two opposite corner regions on the bearing surfaces 20.
- the support surfaces 20 for the strip 14 made of active material are formed by two upwardly protruding knobs 50 in the base film 6 in the area of the first recess 16.
- the two knobs 50 are only shown in the cross-sectional view Fig. 3 can be seen because they are covered by the strip 14 in the other two views.
- the illustrated embodiment of the blister pack 2 according to the invention is constructed similarly to that in FIG Figs. 1 to 3 illustrated and previously described embodiment. Identical elements are provided with the same reference symbols.
- the medical product 4 has a circular base area.
- the strip 14 made of active material in turn has an essentially rectangular base area and its two narrower edge regions lie on the bearing surfaces 20 of the knobs 50 which are arranged on opposite sides of the second recess 18. The strip 14 made of active material thus covers essential parts of the product 4.
- the illustrated embodiment of the blister pack 2 according to the invention is again essentially identical to the embodiment according to FIG Figs. 1 to 3 .
- Identical elements are provided with identical reference symbols.
- the medical product 4 is designed as a sphere.
- the strip 14 made of active material has a recess 22 which is arranged above the medical product 4.
- the medical product 4 can thus pass through the recess 22 of the strip 14 made of active material when it is pressed out.
- the area of the cover film 12 sealed with the strip 14 of active material is thus not broken when the product 4 is pressed out, but only the area of the cover film 12 above the cutout 22.
- the shape of the blister cups 8 can differ from the designs described so far. Any geometric configuration is conceivable, provided that the blister cup 8 has at least a two-step shape.
- the shape of the second recess 18 is preferably based on the shape of the product 4 to be packaged, which can have all possible geometric shapes. In addition to the oblong shape, tablet shape or spherical shape shown so far, triangular or polygonal shapes of the medical products 4 are also possible.
- the shape of the strip 14 made of active material can also differ from the exemplary embodiments illustrated so far.
- the strips 14 can in addition to the one shown rectangular base area, for example, also have round, oval, triangular base areas. In each of these configurations it is possible to provide a recess 22 in the strip.
- the strips 14 are usually blanks.
- the knobs 50 can be arranged on two opposite sides of the second recess 18, as shown in the previous exemplary embodiments. However, it is also possible for more than two knobs 50 to be arranged around the second recess 18.
- a bottom sheet 6 in the form of a roll is provided and unwound.
- the blister cups 8 are formed in the unwound base film 6 in a molding station 24, each blister cup 8 having the at least two-stage shape described above.
- the second recesses 18 of the blister cups 8 are then filled with the medical products 4 in a filling station 26.
- strips 14 of active material are then provided and in each case a strip 14 of active material is placed in the first recess 16 of each blister cup 8 above the medical product 4 on the support surfaces 20 of the knobs 50.
- the strip 14 made of active material is thus preferably arranged above the medical product 4, preferably at a small distance therefrom.
- the strips 14 of active material are preferably provided by providing a web of active material wound into a roll and punching out the strips 14 of active material from the unwound web.
- the strips 14 of active material are preferably deposited by means of a pick & place device. However, it is also possible to provide other forms of transfer for the strips 14 made of active material.
- the cover film 12 is provided and sealed to webs 10 of the base film 6. At the same time, the cover film 12 is also sealed to the strips 14 made of active material. Overall, a sealed blister strip is formed in this way. Finally, individual blister packs 2 are punched out of the blister strip in a punching station 32 located downstream. The individual blister packs 2 are then fed to further processing measures.
- a first molding tool 34 according to the invention and a second molding tool 36 are sketched, which cooperate in the molding station 24 in order to shape the blister cups 8 into the base film 6.
- the two molding tools 34, 36 are movable relative to one another between an open position and a closed molding position.
- at least one of the two forming tools 34, 36 must be movable, preferably both.
- a compressed air source 38 is connected to the second molding tool 36 and ensures that the blister cups 8 are formed in the firmly clamped base film 6.
- the first molding tool 34 comprises at least one, preferably a plurality of troughs 40 for forming at least one blister cup 8 in the bottom foil 6.
- the at least one trough 40 has an at least two-stage shape.
- a first recess 42 of the trough 40 defines a first step of the trough 40.
- a second recess 44 of the trough 40 is arranged in a subsection of a surface area spanned by the first recess 42 and lies deeper than the first recess 42.
- the first molding tool 34 has two protruding projections 46 which are arranged next to the second recess 44.
- the two upwardly protruding knobs 50 are molded into the base film 6 and form the bearing surfaces 20 for the strips 14 made of active material.
- the two projections 46 can be seen again in plan view.
- the shape of the recess 40 thus corresponds to the shape of the blister cups 8 to be formed Fig. 12
- the shape of the depression 40 shown corresponds, for example, to the shape of the blister cups 8 of the blister pack 2 from Figs. 1 to 3 .
- a first inventive sealing tool 54 and a second sealing tool 56 are sketched, which cooperate in the sealing station 30 to seal the cover sheet 12 to the webs 10 of the base sheet 6 and to the strips 14 of active material.
- the two sealing tools 54, 56 are between an open position ( Fig. 13 ) and a closed seal position ( Fig. 14 ) movable relative to each other.
- at least one of the two sealing tools 54, 56 must be movable, preferably both.
- the Second sealing tool 56 has at least one heating means 58.
- the first sealing tool 54 can have a coolant (not shown).
- the first sealing tool 34 comprises at least one, preferably a plurality of troughs 60 for receiving at least one blister cup 8 of the base film 6.
- the at least one trough 60 has an at least two-step shape.
- a first recess 62 of the trough 60 defines a first step of the trough 60.
- a second recess 64 of the trough 60 is arranged in a section of a surface area spanned by the first recess 62 and lies deeper than the first recess 62.
- the shape of the trough 60 corresponds essentially the shape of the blister cups 8 previously formed in the forming station 24. In the specific example, the shape of the trough 60 corresponds to the blister pack Figs. 1 to 3 .
- the first sealing tool 54 has two protrusions 66 protruding upward, which correspond to the shape of the knobs 50 formed in the base film 6 and are arranged at such a point that the knobs 50 come to rest on the protrusions 66 during the sealing process.
- the projections 66 serve to support the knobs 50 of the base film 6 during the sealing process.
- the strips 14 made of active material When placing the strips 14 made of active material on the at least one support surface 20 of the first recess 16, it is advantageous that the strips 14 made of active material by 0.05 mm to 0.5 mm, more preferably by 0.08 mm to 0.2 mm protrude upward over the webs 10 of the bottom sheet.
- the geometry of the blister cups 8 and the knobs 50 in the first sealing tool 54 must accordingly be adapted to the thickness of the strip 14 of active material so that this protrusion is present in the sealing station 30 before the sealing process. This protrusion of the strips 14 ensures that the cover film 12 is not only sealed to the webs 10 of the base film 6, but also to the strips 14 made of active material.
- the sealing tools 54, 56 shown essentially correspond to those in FIG Fig. 13 and 14th sealing tools 54, 56 shown. Identical elements are provided with identical reference numerals.
- the projections 66 in the first sealing tool 54 according to the invention are replaced by pins 68 which extend upwards over the bottom region of the first recess 62 of the trough 60 protrude.
- the pins 68 serve to support the knobs 50 of the base film 6 during the sealing process.
- the pins 68 can be spring loaded as shown.
- the pins 68 can be arranged in the first sealing tool 54 such that they can be extended.
- the knobs 50 in the base film 6 preferably have a height of between 0.5 mm and 5 mm, preferably between 1 mm and 3 mm.
- the projections 46 in the first molding tool 34 and optionally the projections 66 in the first sealing tool 54 also have a height of between 0.5 mm and 5 mm, preferably between 1 mm and 3 mm. If pins 68 are used, they preferably protrude over a height of between 0.5 mm and 5 mm, preferably between 1 mm and 3 mm, over the bottom region of the first recess 62 of the trough 60 or have extended by then.
- the knobs 50 are shown as rounded elevations. Other shapes of the knobs 50 are also conceivable, for example knobs 50 with a triangular cross-sectional shape with a rounded tip or with a flat upper plateau surface on which the strip 14 of active material rests.
- the knobs 50 can also extend as elongated objects along a line (straight, curved).
- the shape of the projections 46, 66 and / or the tips of the pins 68 preferably corresponds in each case to the shape of the knobs 50 in the base film 6.
- a circumferential rib instead of several knobs 50. This is particularly true in the embodiment according to FIG Figures 7 to 9 conceivable.
- Fig. 17 shows this modification in cross-sectional view.
- the circumferential rib 70 can have any desired ring shape in plan view, for example in the form of a circular ring, an oval ring, an angular ring, etc.
- a circumferential, extendable support element 78 could also be used in the first sealing tool 54, the apex of which corresponds to the shape of the rib 70.
- Fig. 20 shows such a design in cross section.
- the support element 78 is preferably spring-loaded.
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Description
Die Erfindung betrifft eine Blisterverpackung für medizinische Produkte, insbesondere Tabletten, Kapseln oder Dragees, und ein Werkzeug zur Herstellung der Blisterverpackung.The invention relates to a blister pack for medical products, in particular tablets, capsules or dragees, and a tool for producing the blister pack.
Üblicherweise bestehen Blisterverpackungen für medizinische Produkte aus einer Bodenfolie, in die eine Mehrzahl von Blisternäpfen eingeformt ist, die mit medizinischen Produkten befüllt sind, und einer Deckfolie. Die Deckfolie ist auf die Bodenfolie aufgesiegelt und verschließt somit die Blisternäpfe, damit die medizinischen Produkte im Blisternapf geschützt aufbewahrt werden können.Blister packs for medical products usually consist of a bottom foil, into which a plurality of blister cups are molded, which are filled with medical products, and a cover foil. The cover film is sealed onto the bottom film and thus closes the blister bowls so that the medical products can be stored in the blister bowl in a protected manner.
Bei bestimmten medizinischen Produkten kann es notwendig sein, im Bereich des Blisternapfes zusätzlich eine Einlage aus Aktivmaterial vorzusehen, die beispielsweise der Trocknung der im versiegelten Napf befindlichen Luft dient, um die Integrität des medizinischen Produkts zu gewährleisten. Üblicherweise werden dazu Einlagen aus Aktivmaterial in eine mit dem Blisternapf verbundene Kammer eingelegt, bevor der Blisternapf mit der Deckfolie versiegelt wird.In the case of certain medical products, it may be necessary to additionally provide an insert made of active material in the area of the blister cup, which is used, for example, to dry the air in the sealed cup in order to ensure the integrity of the medical product. For this purpose, inserts made of active material are usually placed in a chamber connected to the blister cup before the blister cup is sealed with the cover film.
Die
Derartige Blisterverpackungen haben allerdings aufgrund der zusätzlichen Einlagen aus Aktivmaterial erhöhten Platzbedarf. Außerdem müssen die Einlagen aus Aktivmaterial in relativ komplex geformte Kammern der Blisternäpfe eingebracht werden, damit sie beim Ausdrücken des Blisternapfes durch den Nutzer nicht aus dem Blisternapf fallen und versehentlich mit eingenommen werden können. Dadurch wird der Herstellprozess erschwert.Such blister packs, however, have increased space requirements due to the additional inserts made of active material. In addition, the inserts made of active material have to be introduced into relatively complex shaped chambers of the blister cups so that they do not fall out of the blister cup when the user pushes out the blister cup and can be inadvertently taken with it. This makes the manufacturing process more difficult.
Es ist somit die Aufgabe der vorliegenden Erfindung, eine möglichst einfach gestaltete Blisterverpackung für medizinische Produkte mit einem Aktivmaterial im Bereich der Näpfe der Blisterverpackung zu schaffen, die wenig Platz beansprucht und sicher in der Handhabung ist, und ein entsprechendes Werkzeug zur Herstellung einer solchen Blisterverpackung zu schaffen.It is therefore the object of the present invention to create a blister pack that is as simple as possible for medical products with an active material in the area of the wells of the blister pack, which takes up little space and is safe to use, and a corresponding tool for producing such a blister pack create.
Diese Aufgabe wird durch die Merkmale des Anspruchs 1 bzw. des Anspruchs 11 gelöst.This object is achieved by the features of
Die erfindungsgemäße Blisterverpackung für medizinische Produkte, insbesondere Tabletten, Kapseln oder Dragees umfasst eine Bodenfolie, in der mindestens ein Blisternapf eingeformt ist, der von Stegen der Bodenfolie umgeben ist. Der mindestens eine Blisternapf weist eine mindestens zweistufige Form auf derart, dass er eine erste Ausnehmung aufweist, die eine erste Stufe des Blisternapfes definiert, und eine zweite Ausnehmung aufweist, die in einem Teilabschnitt eines von der ersten Ausnehmung überspannten Flächenbereichs angeordnet ist und tiefer liegt als die erste Ausnehmung. Eine Deckfolie überdeckt den mindestens einen Blisternapf und ist an Stege der Bodenfolie gesiegelt. Ein Streifen aus Aktivmaterial ist in dem mindestens einen Blisternapf angeordnet und an die Deckfolie gesiegelt. Das medizinische Produkt ist in der zweiten Ausnehmung aufgenommen und der Streifen aus Aktivmaterial ist in der ersten Ausnehmung aufgenommen. Die erste Ausnehmung weist in einem Bodenbereich eine umlaufende Rippe auf, die um die zweite Ausnehmung herum verläuft, oder mindestens zwei abragende Noppen, die neben der zweiten Ausnehmung angeordnet sind, wobei der Streifen aus Aktivmaterial auf der Rippe oder den Noppen aufliegt.The blister pack according to the invention for medical products, in particular tablets, capsules or dragees, comprises a base film in which at least one blister cup is formed, which is surrounded by webs of the base film. The at least one blister cup has an at least two-step shape such that it has a first recess which defines a first step of the blister cup and a second recess which is arranged in a section of a surface area spanned by the first recess and is lower than the first recess. A cover film covers the at least one blister cup and is sealed to webs of the base film. A strip of active material is arranged in the at least one blister cup and sealed to the cover film. The medical product is received in the second recess and the strip of active material is received in the first recess. The first recess has a circumferential rib in a bottom area that runs around the second recess, or at least two protruding knobs that are arranged next to the second recess, the strip of active material resting on the rib or knobs.
Mit dieser Gestaltung ist die Blisterverpackung auf einfache Weise herstellbar, besticht durch eine sichere Verbindung zwischen dem Streifen aus Aktivmaterial und der Deckfolie im Bereich der Siegelstellen und garantiert eine fehlerfrei Handhabung durch den Nutzer.With this design, the blister pack can be produced in a simple manner, impresses with a secure connection between the strip of active material and the cover film in the area of the sealing points and guarantees error-free handling by the user.
Bevorzugt ist die Rippe oder sind die Noppen einstückig mit der Bodenfolie ausgebildet. Auf diese Weise wird der Aufbau der Blisterverpackung möglichst einfach gestaltet. Ein weiterer Vorteil liegt darin, dass die Rippe oder die Noppen beim Herstellprozess zeitgleich mit den Blisternäpfen in die Bodenfolie geformt werden können.The rib or the knobs are preferably formed in one piece with the bottom foil. In this way, the construction of the blister pack is made as simple as possible. Another advantage is that the rib or the knobs can be molded into the base film at the same time as the blister cups during the manufacturing process.
In bevorzugten Ausgestaltungen weist die Rippe oder weisen die Noppen eine Abrundung am Scheitel oder eine ebene Plateaufläche auf. Hierdurch wird eine geeignete Auflagefläche für den Streifen aus Aktivmaterial gebildet, die beim Siegelvorgang eine Gegenkraft zum oberen Siegelwerkzeug auf den Streifen aus Aktivmaterial und die Deckfolie ausübt. Die Auflagefläche für die Streifen aus Aktivmaterial ist vorzugsweise relativ klein dimensioniert, sodass der durch die Rippe oder die Noppen erzielte Gegendruck über eine relativ geringe Fläche ausgeübt wird, wodurch die Verbindung zwischen der Deckfolie und dem Streifen aus Aktivmaterial im Bereich der Siegelstelle besonders stark ausgeprägt ist.In preferred embodiments, the rib or the knobs have a rounding at the apex or a flat plateau surface. This forms a suitable support surface for the strip of active material which, during the sealing process, exerts a counterforce to the upper sealing tool on the strip of active material and the cover film. The contact surface for the strips of active material is preferably relatively small, so that the counter-pressure achieved by the rib or the knobs is exerted over a relatively small area, whereby the connection between the cover film and the strip of active material is particularly pronounced in the area of the sealing point .
In besonders bevorzugter Ausgestaltung ist der Streifen ein Folienabschnitt und weist eine Dicke von 0,2 mm bis 2 mm, mehr bevorzugt 0,3 mm bis 1,2 mm, auf. Eine solche relativ geringe Dicke ist vorteilhaft im Sinne einer Reduzierung des Platzbedarfs, ist aber gleichzeitig dick genug, um eine verlässliche Handhabung der Streifen beim Herstellprozess zu gewährleisten.In a particularly preferred embodiment, the strip is a film section and has a thickness of 0.2 mm to 2 mm, more preferably 0.3 mm to 1.2 mm. Such a relatively small thickness is advantageous in terms of reducing the space requirement, but is at the same time thick enough to ensure reliable handling of the strips during the manufacturing process.
Vorteilhafterweise weist die Rippe oder weisen die Noppen eine Höhe von zwischen 0,5 mm und 5 mm, bevorzugt zwischen 1 mm und 3 mm, auf. Damit wird ein ausreichender Abstand zwischen dem medizinischen Produkt und dem Streifen aus Aktivmaterial geschaffen.The rib or the knobs advantageously have a height of between 0.5 mm and 5 mm, preferably between 1 mm and 3 mm. This creates a sufficient distance between the medical product and the strip of active material.
Es ist bevorzugt, dass das Aktivmaterial aufgrund seiner Materialeigenschaften eine Aufnahmefunktion zur Aufnahme mindestens einer Substanz oder eine Abgabefunktion zur Abgabe mindestens einer Substanz aufweist. Damit kann je nach Anforderung des medizinischen Produkts die Integrität des Produkts über einen langen Zeitraum gewährleistet werden.It is preferred that the active material, due to its material properties, has an absorption function for absorbing at least one substance or a release function for releasing at least one substance. In this way, depending on the requirements of the medical product, the integrity of the product can be guaranteed over a long period of time.
In einer bevorzugten Ausführungsform sind genau zwei Noppen vorgesehen, die auf gegenüberliegenden Seiten der zweiten Ausnehmung angeordnet sind. In diesem Fall ist die Verbindung zwischen dem Streifen aus Aktivmaterial und der Deckfolie auf das Minimum von genau zwei Siegelstellen beschränkt. Diese beiden Siegelstellen sind entsprechend besonders dauerhaft.In a preferred embodiment, exactly two knobs are provided, which are arranged on opposite sides of the second recess. In this case, the connection between the strip of active material and the cover film is limited to the minimum of exactly two sealing points. These two sealing points are particularly durable.
In einer möglichen Ausgestaltung ist der Streifen aus Aktivmaterial quer zum medizinischen Produkt angeordnet.In one possible embodiment, the strip of active material is arranged transversely to the medical product.
In einer Ausführungsform weist der Streifen aus Aktivmaterial eine Aussparung auf, die über dem medizinischen Produkt angeordnet ist. Auf diese Weise kann das medizinische Produkt durch die Aussparung hindurch aus dem Blisternapf herausgedrückt werden.In one embodiment, the strip of active material has a recess which is arranged above the medical product. In this way, the medical product can be pressed out of the blister cup through the recess.
Das erfindungsgemäße Werkzeug zum Herstellen einer Blisterverpackung für medizinische Produkte, insbesondere Tabletten, Kapseln oder Dragees, umfasst mindestens eine Mulde zur Bildung oder Aufnahme mindestens eines Blisternapfes der Blisterverpackung. Die mindestens eine Mulde weist eine mindestens zweistufige Form auf derart, dass sie eine erste Ausnehmung aufweist, die eine erste Stufe der Mulde definiert, und eine zweite Ausnehmung aufweist, die in einem Teilabschnitt eines von der ersten Ausnehmung überspannten Flächenbereichs angeordnet ist und tiefer liegt als die erste Ausnehmung. Die erste Ausnehmung weist in einem Bodenbereich einen abragenden umlaufenden Vorsprung, der sich um die zweite Ausnehmung herum erstreckt, oder mindestens zwei beabstandete abragende Vorsprünge, die neben der zweiten Ausnehmung angeordnet sind, oder mindestens ein abragendes verschiebbares Stützelement, das sich um die zweite Ausnehmung herum erstreckt, oder mindestens zwei voneinander beabstandete abragende verschiebbare Stifte, die neben der zweiten Ausnehmung angeordnet sind, auf.The tool according to the invention for producing a blister pack for medical products, in particular tablets, capsules or dragees, comprises at least one depression for forming or receiving at least one blister cup of the blister pack. The at least one trough has an at least two-step shape such that it has a first Has recess which defines a first step of the trough, and has a second recess which is arranged in a section of a surface area spanned by the first recess and is lower than the first recess. The first recess has a protruding circumferential projection in a bottom area, which extends around the second recess, or at least two spaced apart protruding projections that are arranged next to the second recess, or at least one protruding displaceable support element that extends around the second recess extends, or at least two spaced apart protruding sliding pins, which are arranged next to the second recess on.
Mit dieser Gestaltung eines Werkzeugs kann die erfindungsgemäße Form einer Blisterverpackung auf einfache und sichere Weise hergestellt werden. Diese Ausgestaltung betrifft zum einen ein Formwerkzeug zum Formen einer entsprechenden Kontur der Blisternäpfe, und zum anderen ein Siegelwerkzeug, bei dem die Versiegelung zwischen Deckfolie und Streifen aus Aktivmaterial an vordefinierten Siegelstellen besonders sicher gelingt.With this design of a tool, the shape of a blister pack according to the invention can be produced in a simple and safe manner. This embodiment relates on the one hand to a molding tool for forming a corresponding contour of the blister cups, and on the other to a sealing tool in which the sealing between the cover film and the strips of active material is particularly reliable at predefined sealing points.
In bevorzugten Ausgestaltungen weisen der Vorsprung oder die Vorsprünge oder das Stützelement oder die Stifte am Scheitel oder an der Spitze eine Abrundung oder eine ebene Plateaufläche auf.In preferred embodiments, the projection or the projections or the support element or the pins have a rounding or a flat plateau surface at the apex or at the tip.
In einer bevorzugten Ausgestaltung sind genau zwei Vorsprünge oder Stifte vorgesehen.In a preferred embodiment, exactly two projections or pins are provided.
Es ist weiterhin bevorzugt, dass mehrere Vorsprünge vorliegen und die Vorsprünge gleich hoch sind und eine Höhe von 0,5 mm bis 5 mm, mehr bevorzugt 1 mm bis 3 mm, aufweisen. Alternativ können mehrere Stifte vorliegen und die Stifte sind derart ausfahrbar, dass sie gleich weit über den Bodenbereich der ersten Ausnehmung vorstehen, bevorzugt um 0,5 mm bis 5 mm, mehr bevorzugt um 1 mm bis 3 mm.It is further preferred that there are several projections and that the projections are of the same height and have a height of 0.5 mm to 5 mm, more preferably 1 mm to 3 mm. Alternatively, there can be several pins and the pins can be extended in such a way that they protrude equally far beyond the bottom area of the first recess, preferably by 0.5 mm to 5 mm, more preferably by 1 mm to 3 mm.
In einer Ausgestaltung liegen ein Stützelement oder mehrere Stifte vor und das Stützelement oder die Stifte sind federgelagert.In one embodiment, there is a support element or a plurality of pins and the support element or pins are spring-loaded.
Weitere Merkmale, Vorteile und Eigenschaft der vorliegenden Erfindung ergeben sich aus der nachfolgenden Beschreibung unter Bezugnahme auf die Zeichnungen.
- Fig. 1
- ist eine Perspektivansicht eines Ausschnitts aus einer Ausführungsform einer erfindungsgemäßen Blisterverpackung, bei der die Deckfolie zum Zwecke der besseren Übersichtlichkeit weggelassen ist;
- Fig. 2
- ist eine Draufsicht auf einen Blisternapf aus der Blisterverpackung aus
Fig. 1 , wobei die Deckfolie zum Zwecke der Übersichtlichkeit weggelassen ist; - Fig. 3
- ist eine Querschnittsansicht eines Napfes der Blisterverpackung aus
Fig. 1 ; - Fig. 4
- ist eine Perspektivansicht eines Ausschnitts aus einer weiteren Ausführungsform einer erfindungsgemäßen Blisterverpackung, bei der die Deckfolie zum Zwecke der Übersichtlichkeit weggelassen ist;
- Fig. 5
- ist eine Draufsicht auf einen Blisternapf der Blisterverpackung aus
Fig. 4 , wobei die Deckfolie zum Zwecke der Übersichtlichkeit weggelassen ist; - Fig. 6
- ist eine Querschnittsansicht eines Blisternapfes der Blisterverpackung aus
Fig. 4 mit aufgesiegelter Deckfolie; - Fig. 7
- ist eine Perspektivansicht eines Ausschnitts aus einer weiteren Ausführungsform einer erfindungsgemäßen Blisterverpackung, bei der die Deckfolie zum Zwecke der Übersichtlichkeit weggelassen ist;
- Fig. 8
- ist eine Draufsicht auf einen Blisternapf der Blisterverpackung aus
Fig. 7 , wobei die Deckfolie zum Zwecke der Übersichtlichkeit weggelassen ist; - Fig. 9
- ist eine Querschnittsansicht eines Blisternapfes der Blisterverpackung aus
Fig. 7 mit aufgesiegelter Deckfolie; - Fig. 10
- ist eine schematische Ansicht einer Anlage zur Herstellung von erfindungsgemäßen Blisterverpackungen;
- Fig. 11
- ist eine schematische Querschnittsansicht einer Formvorrichtung mit einem erfindungsgemäßen Werkzeug, die zur Herstellung der Blisterverpackungen verwendet werden kann;
- Fig. 12
- ist eine Draufsicht auf die Ausnehmung im unteren Formwerkzeug aus
Fig. 11 ; - Fig. 13
- ist eine schematische Schnittansicht einer Siegelvorrichtung mit einem erfindungsgemäßen Werkzeug, die zur Herstellung der Blisterverpackungen verwendet werden kann, in einer geöffneten Position;
- Fig. 14
- ist eine schematische Schnittansicht der Siegelvorrichtung aus
Fig. 13 in einer geschlossenen Siegelposition; - Fig. 15
- ist eine schematische Schnittansicht einer weiteren Siegelvorrichtung mit einem erfindungsgemäßen Werkzeug,, die zur Herstellung der Blisterverpackungen verwendet werden kann, in einer geöffneten Position;
- Fig. 16
- ist eine schematische Schnittansicht der Siegelvorrichtung aus
Fig. 15 in einer geschlossenen Siegelposition; - Fig. 17
- ist eine Querschnittsansicht eines Blisternapfes einer weiteren Ausführungsform der erfindungsgemäßen Blisterverpackung mit aufgesiegelter Deckfolie;
- Fig. 18
- ist eine schematische Querschnittsansicht einer weiteren Formvorrichtung mit einem erfindungsgemäßen Werkzeug, die zur Herstellung der Blisterverpackungen verwendet werden kann;
- Fig. 19
- ist eine schematische Schnittansicht einer weiteren Siegelvorrichtung mit einem erfindungsgemäßen Werkzeug, die zur Herstellung der Blisterverpackungen verwendet werden kann, in einer geöffneten Position; und
- Fig. 20
- ist eine schematische Schnittansicht einer weiteren Siegelvorrichtung mit einem erfindungsgemäßen Werkzeug, die zur Herstellung der Blisterverpackungen verwendet werden kann, in einer geöffneten Position.
- Fig. 1
- is a perspective view of a detail from an embodiment of a blister pack according to the invention, in which the cover film has been omitted for the sake of clarity;
- Fig. 2
- FIG. 14 is a top view of a blister cup from the blister pack of FIG
Fig. 1 , the cover sheet being omitted for the sake of clarity; - Fig. 3
- FIG. 14 is a cross-sectional view of a well of the blister pack of FIG
Fig. 1 ; - Fig. 4
- is a perspective view of a detail from a further embodiment of a blister pack according to the invention, in which the cover film has been omitted for the sake of clarity;
- Fig. 5
- FIG. 14 is a top view of a blister cup of the blister pack from FIG
Fig. 4 , the cover sheet being omitted for the sake of clarity; - Fig. 6
- FIG. 3 is a cross-sectional view of a blister cup of the blister pack of FIG
Fig. 4 with sealed cover film; - Fig. 7
- is a perspective view of a detail from a further embodiment of a blister pack according to the invention, in which the cover film has been omitted for the sake of clarity;
- Fig. 8
- FIG. 14 is a top view of a blister cup of the blister pack from FIG
Fig. 7 , the cover sheet being omitted for the sake of clarity; - Fig. 9
- FIG. 3 is a cross-sectional view of a blister cup of the blister pack of FIG
Fig. 7 with sealed cover film; - Fig. 10
- is a schematic view of a plant for producing blister packs according to the invention;
- Fig. 11
- is a schematic cross-sectional view of a molding device with a tool according to the invention, which can be used to manufacture the blister packs;
- Fig. 12
- FIG. 14 is a top view of the recess in the lower mold of FIG
Fig. 11 ; - Fig. 13
- is a schematic sectional view of a sealing device with a tool according to the invention, which can be used for producing the blister packs, in an open position;
- Fig. 14
- FIG. 3 is a schematic sectional view of the sealing device from FIG
Fig. 13 in a closed sealing position; - Fig. 15
- is a schematic sectional view of a further sealing device with a tool according to the invention, which can be used for producing the blister packs, in an open position;
- Fig. 16
- FIG. 3 is a schematic sectional view of the sealing device from FIG
Fig. 15 in a closed sealing position; - Fig. 17
- is a cross-sectional view of a blister cup of a further embodiment of the blister pack according to the invention with a sealed cover film;
- Fig. 18
- is a schematic cross-sectional view of a further molding device with a tool according to the invention, which can be used to produce the blister packs;
- Fig. 19
- is a schematic sectional view of a further sealing device with a tool according to the invention, which can be used for producing the blister packs, in an open position; and
- Fig. 20
- is a schematic sectional view of a further sealing device with a tool according to the invention, which can be used for producing the blister packs, in an open position.
In
Eine Deckfolie 12, die den mindestens einen Blisternapf 8 überdeckt, ist an die Stege 10 der Bodenfolie 6 gesiegelt und verschließt den mindestens einen Blisternapf 8. Die Deckfolie 12 ist lediglich in
Als Material der Bodenfolie kommen insbesondere PVC, PVDC, Aclar, Aluminium, PETG oder Verbundfolien in Frage. Als Material der Deckfolie kommen insbesondere Aluminium, Polyethylen, Polypropylen, papierkaschierte und weitere Verbundfolien in Frage.PVC, PVDC, Aclar, aluminum, PETG or composite films are particularly suitable as the material for the floor film. Particularly suitable materials for the cover film are aluminum, polyethylene, polypropylene, paper-laminated and other composite films.
Ein Streifen 14 aus Aktivmaterial ist im mindestens einen Blisternapf 8 angeordnet und an die Deckfolie 12 gesiegelt. Die Versiegelung mit der Deckfolie 12 kann vollflächig sein, lediglich über gewisse Flächenbereiche des Streifens 14, entlang von Linien oder auch nur punktuell.A
Das Aktivmaterial weist allgemein aufgrund seiner Materialeigenschaften eine Aufnahmefunktion zur Aufnahme mindestens einer Substanz oder eine Abgabefunktion zur Abgabe mindestens einer Substanz auf. Der am weitesten verbreitete Einsatzzweck ist die Aufnahme von Feuchtigkeit. Bei Streifen 14 mit Aufnahmefunktion können die Streifen 14 aus Aktivmaterial aber beispielsweise auch Sauerstoff, CO2, reaktive Verunreinigungen oder Gerüche aufnehmen. Bei Streifen 14 mit Abgabefunktion können die Streifen 14 aus Aktivmaterial beispielsweise Stickstoff oder Kohlendioxid freisetzen.Due to its material properties, the active material generally has an intake function for absorbing at least one substance or a release function for releasing at least one substance. The most common use is to absorb moisture. In the case of
Ein Streifen 14 aus Aktivmaterial weist vorzugsweise eine Dicke von 0,2 mm bis 2 mm, mehr bevorzugt von 0,3 mm bis 1,2 mm auf. Das Material des Streifens 14 ist vorzugsweise zumindest ein wenig biegesteif, um die Handhabung zu vereinfachen. Das Material des Streifens 14 ist vorzugsweise eine Folie, mehr bevorzugt ein Polymer, besonders bevorzugt ein Dreiphasen-Polymer. Die Folie kann beispielsweise durch Extrusion hergestellt werden, wobei die aktiven Partikel dem Polymer beigefügt werde. Kanäle innerhalb des Polymers ermöglichen eine Bewegung von Gasen. Vorzugsweise liegen die aktiven Partikel als Sphären im Streifen 14 aus Aktivmaterial vor.A
In der Ausführungsform gemäß
Wie aus
Die beiden Auflageflächen 20 für den Streifen 14 aus Aktivmaterial liegen sich auf zwei Seiten der zweiten Ausnehmung 18 diametral gegenüber. Der Streifen 14 aus Aktivmaterial überdeckt somit einen Großteil der zweiten Ausnehmung 18 und liegt mit zwei gegenüberliegenden Eckbereichen auf den Auflageflächen 20 auf.The two bearing
Die Auflageflächen 20 für den Streifen 14 aus Aktivmaterial sind durch zwei nach oben abragende Noppen 50 in der Bodenfolie 6 im Bereich der ersten Ausnehmung 16 gebildet. Die beiden Noppen 50 sind lediglich in der Querschnittsansicht gemäß
Die in
Die in
Die Form der Blisternäpfe 8 kann von den bislang beschriebenen Ausgestaltungen abweichen. Denkbar ist jede geometrische Ausgestaltung, sofern der Blisternapf 8 eine mindestens zweistufige Gestalt besitzt. Die Gestalt der zweiten Ausnehmung 18 richtet sich dabei vorzugsweise nach der Form des zu verpackenden Produkts 4, das alle möglichen geometrischen Formen besitzen kann. Neben der bislang dargestellten Oblong-Form, Drageeform oder Kugelform kommen auch dreieckige oder mehreckige Formen der medizinischen Produkte 4 in Frage.The shape of the blister cups 8 can differ from the designs described so far. Any geometric configuration is conceivable, provided that the
Schließlich kann auch die Form des Streifens 14 aus Aktivmaterial von den bislang dargestellten Ausführungsbeispielen abweichen. Die Streifen 14 können neben der dargestellten rechteckigen Grundfläche beispielsweise auch runde, ovale, dreieckige Grundflächen aufweisen. In jeder dieser Ausgestaltungen ist es möglich, eine Aussparung 22 in dem Streifen vorzusehen. Die Streifen 14 sind in der Regel Zuschnitte.Finally, the shape of the
Die Noppen 50 können auf zwei gegenüberliegenden Seiten der zweiten Ausnehmung 18 angeordnet sein, wie in den bisherigen Ausführungsbeispielen dargestellt. Ebenso ist es aber möglich, dass mehr als zwei Noppen 50 um die zweite Ausnehmung 18 herum angeordnet sind.The
Bezugnehmend auf
In einer Zuführstation 28 werden anschließend Streifen 14 aus Aktivmaterial bereitgestellt und jeweils ein Streifen 14 aus Aktivmaterial wird in die erste Ausnehmung 16 jedes Blisternapfes 8 oberhalb des medizinischen Produkts 4 auf den Auflageflächen 20 der Noppen 50 abgelegt. Der Streifen 14 aus Aktivmaterial ist somit vorzugsweise oberhalb vom medizinischen Produkt 4 angeordnet, vorzugsweise in einem geringen Abstand davon. Bevorzugt erfolgt das Bereitstellen der Streifen 14 aus Aktivmaterial durch Bereitstellen einer zu einer Rolle aufgewickelten Bahn aus Aktivmaterial und Ausstanzen der Streifen 14 aus Aktivmaterial aus der abgewickelten Bahn. Das Ablegen der Streifen 14 aus Aktivmaterial erfolgt vorzugsweise mittels einer Pick & Place-Vorrichtung. Es ist aber auch möglich, andere Übergabeformen für die Streifen 14 aus Aktivmaterial vorzusehen.In a
In einer nachfolgenden Siegelstation 30 wird die Deckfolie 12 bereitgestellt und an Stege 10 der Bodenfolie 6 angesiegelt. Gleichzeitig wird die Deckfolie 12 auch an die Streifen 14 aus Aktivmaterial angesiegelt. Insgesamt wird auf diese Weise eine versiegelte Blisterbahn gebildet. Schließlich erfolgt in einer nachgelagerten Stanzstation 32 das Ausstanzen einzelner Blisterverpackungen 2 aus der Blisterbahn. Die einzelnen Blisterverpackungen 2 werden dann weiteren Bearbeitungsmaßnahmen zugeführt.In a
In
Das erste Formwerkzeug 34 umfasst mindestens eine, vorzugsweise eine Mehrzahl von Mulden 40 zur Bildung mindestens eines Blisternapfes 8 in der Bodenfolie 6. Die mindestens eine Mulde 40 weist eine mindestens zweistufige Form auf. Eine erste Ausnehmung 42 der Mulde 40 definiert eine erste Stufe der Mulde 40. Eine zweite Ausnehmung 44 der Mulde 40 ist in einem Teilabschnitt eines von der ersten Ausnehmung 42 überspannten Flächenbereichs angeordnet und liegt tiefer als die erste Ausnehmung 42.The
Das erste Formwerkzeug 34 weist im Bereich der ersten Ausnehmung 42 der Mulde 40 zwei abragende Vorsprünge 46 auf, die neben der zweiten Ausnehmung 44 angeordnet sind. Dadurch werden beim Formen der Blisternäpfe 8 in die Bodenfolie 6 die zwei nach oben abragenden Noppen 50 in die Bodenfolie 6 eingeformt, die die Auflageflächen 20 für die Streifen 14 aus Aktivmaterial bilden. In
In
Das erste Siegelwerkzeug 34 umfasst mindestens eine, vorzugsweise eine Mehrzahl von Mulden 60 zur Aufnahme mindestens eines Blisternapfes 8 der Bodenfolie 6. Die mindestens eine Mulde 60 weist eine mindestens zweistufige Form auf. Eine erste Ausnehmung 62 der Mulde 60 definiert eine erste Stufe der Mulde 60. Eine zweite Ausnehmung 64 der Mulde 60 ist in einem Teilabschnitt eines von der ersten Ausnehmung 62 überspannten Flächenbereichs angeordnet und liegt tiefer als die erste Ausnehmung 62. Die Form der Mulde 60 entspricht im Wesentlichen der Form der zuvor in der Formstation 24 gebildeten Blisternäpfe 8. Im konkreten Beispiel entspricht die Form der Mulde 60 der Blisterverpackung aus
Das erste Siegelwerkzeug 54 weist zwei nach oben abragende Vorsprünge 66 auf, die der Form der in die Bodenfolie 6 geformten Noppen 50 entsprechen und an einer solchen Stelle angeordnet sind, dass die Noppen 50 während des Siegelprozesses auf den Vorsprüngen 66 zu liegen kommen. Die Vorsprünge 66 dienen zur Stützung der Noppen 50 der Bodenfolie 6 während des Siegelvorgangs.The
Beim Ablegen der Streifen 14 aus Aktivmaterial auf der mindestens einen Auflagefläche 20 der ersten Ausnehmung 16 ist es vorteilhaft, dass die Streifen 14 aus Aktivmaterial um 0,05 mm bis 0,5 mm, mehr bevorzugt um 0,08 mm bis 0,2 mm über die Stege 10 der Bodenfolie nach oben vorstehen. Die Geometrie der Blisternäpfe 8 sowie der Noppen 50 im ersten Siegelwerkzeug 54 ist dementsprechend auf die Dicke des Streifens 14 aus Aktivmaterial anzupassen, so dass dieser Überstand vor dem Siegelvorgang in der Siegelstation 30 vorliegt. Durch diesen Überstand der Streifen 14 wird sichergestellt, dass die Deckfolie 12 nicht nur an die Stege 10 der Bodenfolie 6 gesiegelt wird, sondern auch an die Streifen 14 aus Aktivmaterial.When placing the
Die in
Die Noppen 50 in der Bodenfolie 6 weisen vorzugsweise eine Höhe von zwischen 0,5 mm und 5 mm, bevorzugt zwischen 1 mm und 3 mm auf. Dementsprechend weisen auch die Vorsprünge 46 im ersten Formwerkzeug 34 und gegebenenfalls die Vorsprünge 66 im ersten Siegelwerkzeug 54 eine Höhe von zwischen 0,5 mm und 5 mm, bevorzugt zwischen 1 mm und 3 mm auf. Wenn Stifte 68 verwendet werden, stehen diese vorzugsweise über eine Höhe von zwischen 0,5 mm und 5 mm, bevorzugt zwischen 1 mm und 3 mm, über den Bodenbereich der ersten Ausnehmung 62 der Mulde 60 vor oder sind bis dahin ausgefahren.The
In den dargestellten Ausführungsformen sind die Noppen 50 als abgerundete Erhebungen dargestellt. Ebenso sind andere Formen der Noppen 50 denkbar, beispielsweise Noppen 50 mit einer dreieckigen Querschnittsform mit abgerundeter Spitze oder mit einer ebenen oberen Plateaufläche, auf der der Streifen 14 aus Aktivmaterial aufliegt. Die Noppen 50 können sich auch als längliche Objekte entlang einer Linie (gerade, gekrümmt) erstrecken. Die Form der Vorsprünge 46, 66 und/oder der Spitzen der Stifte 68 entspricht vorzugsweise jeweils der Form der Noppen 50 in der Bodenfolie 6.In the illustrated embodiments, the
Es ist auch möglich, anstelle von mehreren Noppen 50 eine umlaufende Rippe auszubilden. Dies ist insbesondere bei der Ausführungsform gemäß
Zur Herstellung von Blisterverpackungen wie in
Ebenso wird vorzugsweise lediglich ein ebenso geformter, umlaufender Vorsprung 86 im ersten Siegelwerkzeug 54 ausgebildet sein, wie aus der Querschnittsansicht aus
Alternativ könnte im ersten Siegelwerkzeug 54 auch ein umlaufendes, ausfahrbares Stützelement 78 verwendet werden, dessen Scheitel der Form der Rippe 70 entspricht.
Für die Querschnittsform der Rippe 70, des Vorsprungs 76, des Vorsprungs 86 oder des Scheitels des Stützelements 78 gilt dann Entsprechendes wie für die Querschnittsform der Noppen 50.For the cross-sectional shape of the
Claims (15)
- Blister package (2) for medicinal products (4), in particular tablets, capsules or coated tablets, having a bottom sheet (6) into which at least one blister cavity (8) which is surrounded by webs (10) of the bottom sheet (6) is formed, wherein the at least one blister cavity (8) has an at least two-stage form in such a way that it has a first recess (16), which defines a first stage of the blister cavity (8), and has a second recess (18), which is arranged in a subportion of an area region spanned by the first recess (16) and which lies deeper than the first recess (16);
a cover sheet (12) which covers the at least one blister cavity (8) and is sealed to webs (10) of the bottom sheet (6) ;
a strip (14) made of active material, said strip being arranged in the at least one blister cavity (8) and being sealed to the cover sheet (12);
wherein the medicinal product (4) is received in the second recess (18) and the strip (14) made of active material is received in the first recess (16);
characterized in that
the first recess (16) has, in a bottom region, a peripheral rib (70), which runs around the second recess (18), or at least two projecting nubs (50), which are arranged alongside the second recess (18), wherein the strip (14) made of active material rests on the rib (70) or the nubs (50). - Blister package (2) according to Claim 1, characterized in that the rib (70) or the nubs (50) is or are configured in one piece with the bottom sheet (6).
- Blister package (2) according to Claim 1 or 2, characterized in that the rib (70) or the nubs (50) has or have a rounding at the crown or a flat plateau surface.
- Blister package (2) according to one of the preceding claims, characterized in that the strip (14) is a sheet portion.
- Blister package (2) according to one of the preceding claims, characterized in that the strip (14) has a thickness of 0.2 mm to 2 mm, preferably 0.3 mm to 1.2 mm.
- Blister package (2) according to one of the preceding claims, characterized in that the rib (70) or the nubs (50) has or have a height of between 0.5 mm and 5 mm, preferably between 1 mm and 3 mm.
- Blister package (2) according to one of the preceding claims, characterized in that the active material, on account of its material properties, has an absorbing function for absorbing at least one substance or a releasing function for releasing at least one substance.
- Blister package (2) according to one of the preceding claims, characterized in that exactly two nubs (50) are provided, which are arranged on opposite sides of the second recess (18).
- Blister package (2) according to one of the preceding claims, characterized in that the strip (14) made of active material is arranged transversely with respect to the medicinal product (4).
- Blister package (2) according to one of the preceding claims, characterized in that the strip (14) made of active material has a cutout (22) which is arranged above the medicinal product (4).
- Tool (34, 54) for producing a blister package (2) for medicinal products (4), in particular tablets, capsules or coated tablets, having
at least one trough (40, 60) for forming or receiving at least one blister cavity (8) of the blister package (2), wherein the at least one trough (40, 60) has an at least two-stage form in such a way that it has a first recess (42, 62), which defines a first stage of the trough (40, 60), and has a second recess (44, 64), which is arranged in a subportion of an area region spanned by the first recess (42, 62) and which lies deeper than the first recess (42, 62);
characterized in that
the first recess (42, 62) has, in a bottom region, a projecting peripheral protrusion (76, 86) which extends around the second recess (44, 64), or at least two spaced-apart projecting protrusions (46, 66) which are arranged alongside the second recess (44, 64), or at least one projecting displaceable support element (78) which extends around the second recess (44, 64), or at least two spaced-apart projecting displaceable pins (68) which are arranged alongside the second recess (44, 64). - Tool (34, 54) according to Claim 11, characterized in that the protrusion (76, 86) or the protrusions (46, 66) or the support element (78) or the pins (68) has/have a rounding or a flat plateau surface at the crown or at the tip.
- Tool (34, 54) according to Claim 11 or 12, characterized in that exactly two protrusions (46, 66) or pins (68) are provided.
- Tool (34, 54) according to one of Claims 11 to 13, characterized in that a plurality of protrusions (46, 66) are present, and the protrusions (46, 66) are of identical height and have a height of 0.5 mm to 5 mm, more preferably 1 mm to 3 mm, or in that a plurality of pins (68) are present, and the pins (68) can be extended in such a way that they protrude to the same extent above the bottom region of the first recess (62), preferably by 0.5 mm to 5 mm, more preferably by 1 mm to 3 mm.
- Tool (34, 54) according to one of Claims 11 to 14, characterized in that a support element (78) or a plurality of pins (68) is/are present, and the support element (78) or the pins (68) is or are spring mounted.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI201830150T SI3599188T1 (en) | 2018-07-26 | 2018-07-26 | Blister package for medical products and tool for producing the blister package |
EP18185814.3A EP3599188B1 (en) | 2018-07-26 | 2018-07-26 | Blister package for medical products and tool for producing the blister package |
HUE18185814A HUE051758T2 (en) | 2018-07-26 | 2018-07-26 | Blister package for medical products and tool for producing the blister package |
KR1020190083227A KR102218096B1 (en) | 2018-07-26 | 2019-07-10 | Blister pack for medicinal products and tool for producing the blister pack |
US16/521,888 US11446205B2 (en) | 2018-07-26 | 2019-07-25 | Blister pack for medicinal products and tool for producing the blister pack |
CN201910682517.6A CN110395484B (en) | 2018-07-26 | 2019-07-26 | Blister pack for pharmaceutical products and tool for producing blister packs |
CN202110551118.3A CN113197777B (en) | 2018-07-26 | 2019-07-26 | Blister pack for pharmaceutical products and tool for producing blister pack |
US17/196,074 US11857493B2 (en) | 2018-07-26 | 2021-03-09 | Blister pack for medicinal products and tool for producing the blister pack |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18185814.3A EP3599188B1 (en) | 2018-07-26 | 2018-07-26 | Blister package for medical products and tool for producing the blister package |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3599188A1 EP3599188A1 (en) | 2020-01-29 |
EP3599188B1 true EP3599188B1 (en) | 2020-09-09 |
Family
ID=63077788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18185814.3A Active EP3599188B1 (en) | 2018-07-26 | 2018-07-26 | Blister package for medical products and tool for producing the blister package |
Country Status (6)
Country | Link |
---|---|
US (2) | US11446205B2 (en) |
EP (1) | EP3599188B1 (en) |
KR (1) | KR102218096B1 (en) |
CN (2) | CN110395484B (en) |
HU (1) | HUE051758T2 (en) |
SI (1) | SI3599188T1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US11396413B2 (en) | 2018-09-20 | 2022-07-26 | Csp Technologies, Inc. | One or more blister packages containing active material and methods of making and using same |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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AR117777A1 (en) | 2019-01-09 | 2021-08-25 | Csp Technologies Inc | CELLULAR CONTAINERS CONTAINING AN ACTIVE MATERIAL AND METHODS FOR MANUFACTURING AND USING THEM |
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2019
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Also Published As
Publication number | Publication date |
---|---|
US11857493B2 (en) | 2024-01-02 |
US20200030185A1 (en) | 2020-01-30 |
HUE051758T2 (en) | 2021-03-29 |
EP3599188A1 (en) | 2020-01-29 |
SI3599188T1 (en) | 2020-12-31 |
US11446205B2 (en) | 2022-09-20 |
US20210186807A1 (en) | 2021-06-24 |
CN110395484B (en) | 2021-09-10 |
CN113197777B (en) | 2024-08-20 |
KR102218096B1 (en) | 2021-02-22 |
CN113197777A (en) | 2021-08-03 |
KR20200012734A (en) | 2020-02-05 |
CN110395484A (en) | 2019-11-01 |
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