EP3589315A4 - Compositions et procédés pour induire des anticorps anti-vih-1 - Google Patents
Compositions et procédés pour induire des anticorps anti-vih-1 Download PDFInfo
- Publication number
- EP3589315A4 EP3589315A4 EP18760878.1A EP18760878A EP3589315A4 EP 3589315 A4 EP3589315 A4 EP 3589315A4 EP 18760878 A EP18760878 A EP 18760878A EP 3589315 A4 EP3589315 A4 EP 3589315A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antibodies
- compositions
- methods
- inducing hiv
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001939 inductive effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2017/020823 WO2017152146A2 (fr) | 2016-03-03 | 2017-03-03 | Compositions et procédés pour induire des anticorps du vih-1 |
US201862624620P | 2018-01-31 | 2018-01-31 | |
PCT/US2018/020788 WO2018161049A1 (fr) | 2017-03-03 | 2018-03-02 | Compositions et procédés pour induire des anticorps anti-vih-1 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3589315A1 EP3589315A1 (fr) | 2020-01-08 |
EP3589315A4 true EP3589315A4 (fr) | 2021-06-23 |
Family
ID=63371208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18760878.1A Pending EP3589315A4 (fr) | 2017-03-03 | 2018-03-02 | Compositions et procédés pour induire des anticorps anti-vih-1 |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3589315A4 (fr) |
CA (1) | CA3055204A1 (fr) |
WO (1) | WO2018161049A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017151801A1 (fr) | 2016-03-01 | 2017-09-08 | Duke University | Compositions comprenant des enveloppes de vih pour induire des anticorps de lignée ch235 |
US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
US11246920B2 (en) | 2016-03-03 | 2022-02-15 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
CA3039089A1 (fr) | 2016-10-03 | 2018-04-12 | Duke University | Procedes d'identification d'immunogenes par ciblage de mutations improbables |
US20210009640A1 (en) * | 2018-03-02 | 2021-01-14 | Duke University | Compositions comprising hiv envelopes to induce hiv-1 antibodies |
WO2020072162A1 (fr) * | 2018-10-01 | 2020-04-09 | Duke University | Compositions comprenant des enveloppes de vih pour induire des anticorps contre le vih-1 |
AU2019393745A1 (en) | 2018-12-04 | 2021-06-10 | California Institute Of Technology | HIV vaccine immunogens |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014043386A1 (fr) * | 2012-09-12 | 2014-03-20 | Duke University | Anticorps du lignage clonal |
WO2015153638A1 (fr) * | 2014-03-31 | 2015-10-08 | Duke University | Compositions comprenant des enveloppes de ch848, et leurs utilisations |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015127108A1 (fr) | 2014-02-19 | 2015-08-27 | Duke University | Enveloppes du vih -1 trimères des compositions et leurs utilisations |
EP3189067B1 (fr) | 2014-09-04 | 2021-05-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Protéines de l'enveloppe du vih-1 et leur utilisation |
-
2018
- 2018-03-02 EP EP18760878.1A patent/EP3589315A4/fr active Pending
- 2018-03-02 CA CA3055204A patent/CA3055204A1/fr active Pending
- 2018-03-02 WO PCT/US2018/020788 patent/WO2018161049A1/fr unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014043386A1 (fr) * | 2012-09-12 | 2014-03-20 | Duke University | Anticorps du lignage clonal |
WO2015153638A1 (fr) * | 2014-03-31 | 2015-10-08 | Duke University | Compositions comprenant des enveloppes de ch848, et leurs utilisations |
Non-Patent Citations (5)
Title |
---|
A. P. WEST ET AL: "Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, no. 30, 24 July 2012 (2012-07-24), pages E2083 - E2090, XP055166144, ISSN: 0027-8424, DOI: 10.1073/pnas.1208984109 * |
FLORIAN KLEIN ET AL: "Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization", CELL, vol. 153, no. 1, 1 March 2013 (2013-03-01), pages 126 - 138, XP055119651, ISSN: 0092-8674, DOI: 10.1016/j.cell.2013.03.018 * |
H. MOUQUET ET AL: "Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, no. 47, 30 October 2012 (2012-10-30), pages E3268 - E3277, XP055068116, ISSN: 0027-8424, DOI: 10.1073/pnas.1217207109 * |
HUA-XIN LIAO ET AL: "Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus", NATURE, vol. 496, no. 7446, 3 April 2013 (2013-04-03), London, pages 469 - 476, XP055226788, ISSN: 0028-0836, DOI: 10.1038/nature12053 * |
See also references of WO2018161049A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP3589315A1 (fr) | 2020-01-08 |
WO2018161049A8 (fr) | 2018-10-04 |
CA3055204A1 (fr) | 2018-09-07 |
WO2018161049A1 (fr) | 2018-09-07 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 31/18 20060101ALI20201216BHEP Ipc: C07K 14/16 20060101ALI20201216BHEP Ipc: A61K 39/12 20060101AFI20201216BHEP Ipc: A61K 9/127 20060101ALI20201216BHEP Ipc: C12Q 1/68 20180101ALI20201216BHEP |
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