EP3589129A1 - Compositions sélectionnées de manière ciblée comportant des cannabinoïdes purifiés et/ou des terpènes purifiés - Google Patents

Compositions sélectionnées de manière ciblée comportant des cannabinoïdes purifiés et/ou des terpènes purifiés

Info

Publication number
EP3589129A1
EP3589129A1 EP18760302.2A EP18760302A EP3589129A1 EP 3589129 A1 EP3589129 A1 EP 3589129A1 EP 18760302 A EP18760302 A EP 18760302A EP 3589129 A1 EP3589129 A1 EP 3589129A1
Authority
EP
European Patent Office
Prior art keywords
purified
cannabinoid
terpene
alpha
thc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18760302.2A
Other languages
German (de)
English (en)
Other versions
EP3589129A4 (fr
Inventor
Kurt LEVY
Jonathan Michael COOPER
Jonathan Reed MARTIN
Brian Geoffrey REID
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Canopy Growth Corp
Original Assignee
Canopy Growth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/616,874 external-priority patent/US20170266153A1/en
Application filed by Canopy Growth Corp filed Critical Canopy Growth Corp
Publication of EP3589129A1 publication Critical patent/EP3589129A1/fr
Publication of EP3589129A4 publication Critical patent/EP3589129A4/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 

Definitions

  • This disclosure relates to the cannabis industry.
  • this disclosure relates to compositions and formulations comprising new, purposefully engineered combinations of purified compounds.
  • Crobis refers to a genus of flowering plants. Plants of genus cannabis include several species, including Cannabis sativa, Cannabis indica, and Cannabis ruderalis. There is a long history of cultivating plants of genus cannabis for hemp fibers, seeds and seed oils, medicinal purposes, and recreational activities.
  • cannabis is composed of at least 483 known chemical compounds, which include cannabinoids, terpenoids, flavonoids, nitrogenous compounds, amino acids, proteins, glycoproteins, enzymes, sugars and related compounds, hydrocarbons, alcohols, aldehydes, ketones, acids, fatty acids, esters, lactones, steroids, terpenes, non-cannabinoid phenols, vitamins, and pigments.
  • cannabinoids include cannabinoids, terpenoids, flavonoids, nitrogenous compounds, amino acids, proteins, glycoproteins, enzymes, sugars and related compounds, hydrocarbons, alcohols, aldehydes, ketones, acids, fatty acids, esters, lactones, steroids, terpenes, non-cannabinoid phenols, vitamins, and pigments.
  • Cannabinoids are of particular interest for research and commercialization. Most extractions of cannabis plant matter aim to extract cannabinoids, particularly tetrahydrocannabinol (THC). THC is useful for relieving pain, treating glaucoma, and relieving nausea. THC is also gaining immense popularity as a recreational drug substance. Usually, cannabinoids are extracted from the cannabis plant as part of a crude mixture, combined with other chemical compounds found in the cannabis plant.
  • THC tetrahydrocannabinol
  • compositions comprising new man-made combinations of purified cannabis components.
  • compositions comprising new combinations of at least one cannabinoid and at least one purified terpene.
  • compositions comprising purified cannabinoids and/or purified terpenes.
  • the compositions comprise a first purified cannabinoid and a first purified terpene.
  • the compositions comprise a first purified cannabinoid and a second purified cannabinoid.
  • the compositions comprise a first purified cannabinoid, a second purified cannabinoid, and a first purified terpene.
  • the compositions comprise a first purified cannabinoid, a first purified terpene, and a second purified terpene.
  • compositions disclosed herein are purposefully formulated to provide man-made, non- naturally occurring combinations, concentrations, and/or ratios of compounds sometimes found in naturally occurring cannabis plants.
  • compositions disclosed herein include a non-naturally occurring ratio of a first purified cannabinoid and a first purified terpene. In one embodiment, the compositions disclosed herein include a non-naturally occurring concentration of a first purified cannabinoid and a first purified terpene.
  • compositions disclosed herein include a non-naturally occurring ratio of a first purified cannabinoid and a second purified cannabinoid. In one embodiment, the compositions disclosed herein include a non-naturally occurring concentration of a first purified cannabinoid and a second purified cannabinoid.
  • compositions disclosed herein include a non-naturally occurring ratio of a first purified cannabinoid, a second purified cannabinoid, and a first purified terpene. In one embodiment, the compositions disclosed herein include a non-naturally occurring concentration of a first purified cannabinoid, a second purified cannabinoid, and a first purified terpene.
  • compositions disclosed herein include a non-naturally occurring ratio of a first purified cannabinoid, a second purified cannabinoid, and a third purified cannabinoid. In one embodiment, the compositions disclosed herein include a non-naturally occurring concentration of a first purified cannabinoid, a second purified cannabinoid, and a third purified cannabinoid.
  • compositions disclosed herein include a non-naturally occurring ratio of a first purified terpene, a second purified terpene, and a first purified cannabinoid. In one embodiment, the compositions disclosed herein include a non-naturally occurring concentration of a first purified terpene, a second purified terpene, and a first purified cannabinoid.
  • compositions comprise an unnaturally occurring ratio of 10: 1 - 1: 1 of a purified cannabinoid to purified terpene. In one embodiment of this disclosure, the compositions comprise an unnaturally occurring ratio of 10: 1 - 5: 1 of a purified cannabinoid to purified terpene.
  • compositions comprise an unnaturally occurring ratio of greater than 10: 1 of a purified cannabinoid to purified terpene.
  • compositions comprising:
  • composition chosen from a second purified cannabinoid or a first purified terpene, wherein the said composition is substantially free from cellulose.
  • purified means extracted, isolated, and/or separated from other compounds, formulations, compositions, matter, and/or mass.
  • purified refers to a cannabinoid that is separated from the plant matter from which it was derived.
  • the term “purified” refers to a cannabinoid (a “purified cannabinoid”) that is separated from other cannabinoids that were present in the plant matter from which it was derived. In one embodiment, the term “purified” refers to a cannabinoid (a “purified cannabinoid”) that is separated from terpenes that were present in the plant matter from which it was derived. In one embodiment, the term “purified” refers to a cannabinoid (a “purified cannabinoid”) that is separated from secondary compounds that were present in the plant matter from which it was derived. In one embodiment, the term “purified” refers to a cannabinoid (a “purified cannabinoid”) that is separated from all material that was present in the plant matter from which it was derived.
  • the term “purified” refers to a terpene (a "purified terpene”) that is separated from other cannabinoids that were present in the plant matter from which it was derived. In one embodiment, the term “purified” refers to a terpene (a “purified terpene”) that is separated from terpenes that were present in the plant matter from which it was derived. In one embodiment, the term “purified” refers to a terpene (a “purified terpene”) that is separated from secondary compounds that were present in the plant matter from which it was derived. In one embodiment, the term “purified” refers to a terpene (a “purified terpene”) that is separated from all material that was present in the plant matter from which it was derived.
  • purified compounds may be purposely formulated with other compounds at various levels of purity.
  • a particular cannabinoid or terpene may be formulated with other molecules when it is 60-65% pure, 65-70% pure, 70-75% pure, 75-80% pure, 80-85% pure, 85-90% pure, 90-95% pure, 95-99% pure, 99-99.9% pure, 99.9+%, or greater than 99% pure.
  • the ingredients used for purposeful formulation are purified prior to the said purposeful formulation, the act of subsequently formulating them does render them not "purified" within the context of an ingredient list.
  • purified means “substantially free” from other material, e.g., compounds, particles, vegetative material, plant derived substances, solvents, etc.
  • purified refers to a compound purified from a crude extract, such as a biologically derived substance or BDS, thereby resulting in a significant difference between the purified compound and the extract.
  • substantially free means that the compound comprises no (or insignificant amounts) of other materials.
  • plant refers to the whole plant and parts of the plant, e.g., leaves, roots, bark, flower, etc.
  • the term plant also encompasses a dried plant and dried parts of the plant.
  • the term "purified” includes isolated stereoisomers and also mixtures of stereoisomers, provided that the compound having the stereoisomers is free from other compounds having different atomic connectivity.
  • manmade means engineered or purposefully created by a human in contrast to naturally "in nature” without human influence.
  • manmade compositions are formulations made by combining naturally occurring molecules in a new unnatural way, for example by separating the individual chemical components of a plant and then recombining some of those components to achieve different concentrations and/or ratios of those components.
  • manmade compositions are formulations made with one or more processes in a chemical extraction and purification lab.
  • compositions of this disclosure-- made by purposefully combining purified compounds with concentrations, combinations and/or ratios-differ from previously existing technology, such as extracts or other processed materials, e.g., biological drug substance, medically grade plant extracts, etc.
  • purification comprises using various solvents, e.g., ethanol, butane, methane, carbon dioxide, ice, water, steam.
  • purification comprises various techniques, e.g., chromatography, crystallization, filtration, centrifuge, etc. or various combinations of said techniques.
  • purification comprises extracting cannabinoids and other plant molecules from plants bred to express desired cannabinoid and/or terpene profiles for purity.
  • cellulose means an organic compound with the formula (C6Hio05)n.
  • the phrase “substantially free from cellulose” is intended to distinguish purified components of naturally occurring plants (for example the cannabis plant) from the isolated chemical compounds that are free from plant material, such as cellulose.
  • naturally occurring refers to materializing, arising, happening, or synthesizing in nature.
  • naturally occurring refers to a secondary compound synthesized within a plant.
  • naturally occurring refers to a collection of cannabinoids synthesized within a plant of genus cannabis.
  • naturally occurring refers to the concentrations of compounds within a plant.
  • naturally occurring refers to the concentration of cannabinoids within a plant of genus cannabis.
  • naturally occurring refers to the ratio of secondary compounds within a plant.
  • the naturally occurring refers to the ratio of a first cannabinoid to a second cannabinoid within a plant of genus cannabis.
  • the term "naturally occurring ratio" refers to the proportion of one compound or compounds in relation to another compound or compounds within a plant of genus cannabis.
  • the naturally occurring ratio is the amount of a cannabinoid in relation to the amount of a cannabinoid within a plant of genus cannabis.
  • the naturally occurring ratio is the amount of a cannabinoid in relation to the amount of a terpene within a plant of genus cannabis.
  • the naturally occurring ratio is the amount of a cannabinoid in relation to the amount of a terpene within a flower of genus cannabis.
  • the naturally occurring ratio is the amount of a cannabinoid in relation to the amount of a terpene within a plant extract of genus. In one embodiment, the naturally occurring ratio is the amount of a cannabinoid in relation to the amount of a terpene within a formulation made from plant extract of genus cannabis.
  • the naturally occurring ratio is expressed as a molar ratio. In one embodiment, the naturally occurring ratio is expressed as a mass. In one embodiment, the mass and/or molar ratio is measured by chromatography and/or spectroscopy.
  • the term "unnaturally occurring ratio” refers to the proportion of one compound or compounds in relation to another compound or compounds in a composition created by a human.
  • the unnaturally occurring ratio is the amount of a cannabinoid in relation to a terpene and is not observed in a plant of genus cannabis.
  • the unnaturally occurring ratio is expressed as a molar ratio.
  • the unnaturally occurring ratio is expressed as a mass.
  • the mass and/or molar ratio is measured by chromatography and/or spectroscopy.
  • the unnaturally occurring ratio is the amount of a cannabinoid in relation to the amount of a terpene within a composition formulated by a human not observed in a plant of genus cannabis. In one embodiment, the unnaturally occurring ratio is the amount of a cannabinoid in relation to the amount of a second cannabinoid within a composition formulated by a human not observed in a plant of genus cannabis.
  • the term "naturally occurring concentration” refers to the amount of a compound or compounds in relation to an entire naturally occurring reference sample.
  • the naturally occurring concentration is the amount of a cannabinoid in a sample of a plant of genus cannabis.
  • the naturally occurring concentration is the amount of a cannabinoid within the dried, or cured, flower of a plant of genus cannabis.
  • the naturally occurring concentration is the amount of a cannabinoid within a crude extract of a plant of genus cannabis.
  • the naturally occurring concentration is the amount of a terpene in a sample of a plant of genus cannabis. In one embodiment, the naturally occurring concentration is the amount of a terpene within the dried, or cured, flower of a plant of genus cannabis. In one embodiment, the naturally occurring concentration is the amount of a terpene within a crude extract of a plant of genus cannabis. In one embodiment, the unnaturally occurring concentration is measured by moles and expressed as Molarity. In one embodiment, the naturally occurring concentration is measured by percent mass.
  • the term "unnaturally occurring concentration” refers to the amount of a compound or compounds in relation to an entire sample within a manmade composition. In one embodiment, the unnaturally occurring concentration is the amount of a cannabinoid in relation to the total composition. In one embodiment, the unnaturally occurring concentration is the amount of a terpene in relation to the total composition. In one embodiment, the unnaturally occurring concentration is measured by moles and expressed as Molarity. In one embodiment, the unnaturally occurring concentration is measured by percent mass.
  • total mass refers to the entire amount of matter for a given reference sample. In one embodiment, the total mass is measured by molecular mass.
  • pharmacological fingerprint refers to a collection of data about the activity of a single cannabinoid or terpene, or any combination of cannabinoids and/or terpenes, at one or more targets in the human body, e.g., a cannabinoid receptor, e.g., CB1, CB2, GPR55, 5HT-1A, 5HT-2A, TRPV1, serotonin receptor, or ⁇ -opioid receptor.
  • a cannabinoid receptor e.g., CB1, CB2, GPR55, 5HT-1A, 5HT-2A, TRPV1, serotonin receptor, or ⁇ -opioid receptor.
  • the compositions disclosed herein were created using cellular (e.g., pharmacological fingerprint) and/or clinical data to select and combine particular combinations of compounds having new properties.
  • potency refers to the power, influence, activity, or effectiveness of the compositions disclosed herein at a particular cellular receptor.
  • potency is measured by the response of a subject.
  • potency is measured by the cellular reactivity of a cannabinoid at a receptor, e.g., CB1, CB2, GPR55, 5HT-1A, 5HT-2A, TRPV1, serotonin receptor, or ⁇ -opioid receptor.
  • potency refers to the EC50.
  • potency refers to amplitude of response.
  • the term “agonism” refers to the effect of a compound, agonist, activating a receptor and inducing a response.
  • the receptor is chosen from CB1, CB2, GPR55, 5HT-1A, 5HT-2A, TRPV1, serotonin receptor, or ⁇ -opioid receptor.
  • the agonist is a cannabinoid.
  • the agonist is a terpene.
  • the term “antagonism” refers to two or more compounds in combination having an effect.
  • antagonism is a composition comprising a cannabinoid affecting another cannabinoid, i.e., a cannabinoid affecting the binding of another cannabinoid to a receptor.
  • antagonism is a composition comprising a terpene affecting another cannabinoid, i.e., a terpene affecting the binding of another cannabinoid to a receptor.
  • compositions disclosed herein modify the potency of an endogenous neurotransmitter within an organism, e.g., a serotonin receptor, an adrenergic receptor, a dopamine receptor, a GABAergic receptor, a glutaminergic receptor, a histaminergic receptor, a cholinergic receptor, an opioid receptor, a glycinergic receptor, etc., at one or more of its endogenous receptors, e.g., serotonin, norepherine, adrenaline, dopamine, etc.
  • an endogenous neurotransmitter within an organism, e.g., a serotonin receptor, an adrenergic receptor, a dopamine receptor, a GABAergic receptor, a glutaminergic receptor, a histaminergic receptor, a cholinergic receptor, an opioid receptor, a glycinergic receptor, etc.
  • compositions disclosed herein increase the potency of serotonin at the 5-HTiA receptor. In one embodiment, the compositions disclosed herein increase the potency of serotonin at the 5-HT2A receptor. In one embodiment, the compositions disclosed herein increase the potency of serotonin at the 5-HTIA receptor and decrease the potency of serotonin at the 5-HT2A receptor. In one embodiment, the compositions disclosed herein decrease the potency of serotonin at the 5-HTIA receptor and increase the potency of serotonin at the 5-HT2A receptor.
  • formulations of this disclosure have been achieved by expressing the human components of the endocannabinoid system (or other known targets of cannabis pharmacology) in cultured cells and treating the cells with serial dilutions of individual compounds or combinations of compounds in order to determine the EC50s of each component at each target individually, and whether adding other components shifts either the amplitude of the response or the effective concentration (EC50) of the response.
  • the term “EC50” means “half maximal effective concentration,” which refers to the concentration of a formulation (e.g., a cannabinoid, terpene, or combination thereof) inducing a response halfway between the baseline and maximum after a specified exposure time.
  • the EC50 value is used as a measure of a drug's potency.
  • the EC50 of a graded dose response curve represents the concentration of a compound where 50% of its maximal effect is observed.
  • the EC50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, after a specified exposure duration.
  • the term "amplitude of response" refers to the magnitude of reactivity to the compositions disclosed herein.
  • the amplitude of response is the reaction of a receptor, e.g., CB 1, CB2, GPR55, 5HT- 1A, 5HT-2A, TRPV 1, serotonin receptor, or ⁇ -opioid receptor, to a sample administered thereto.
  • a receptor e.g., CB 1, CB2, GPR55, 5HT- 1A, 5HT-2A, TRPV 1, serotonin receptor, or ⁇ -opioid receptor
  • D9-THC activity at cannabinoid receptor 1 has a consistent EC50 of around 1 micromolar, and a 40 - 50% amplitude of response compared to a known, synthetic full agonist (CP-55,940).
  • CP-55,940 cannabinoid receptor 1
  • the lower response of CBl to THC relative to a full agonist is why THC is referred to as a "partial agonist" of the CB 1 receptor.
  • the purposefully engineered formulations disclosed herein were developed by establishing the EC50 of THC at CBl numerous times and determining EC50s of THC in a background of constant concentrations of other cannabinoids and terpenes. This is one example of a method for determining how particular cannabis components my either synergize, add to, or compete with the THC response itself.
  • compositions disclosed herein provide unprecedented control over the effects of cannabinoids and/or terpenes on the user.
  • the composition provides a decrease in the EC50 for either or both of a first purified cannabinoid and/or a second purified cannabinoid at a particular receptor.
  • the composition provides an increase in the EC50 for either or both of the purified cannabinoid and/or a second purified cannabinoid at a particular receptor, for example the CBl, CB2 GPR55, 5HT-1A, 5HT-2A, TRPV1, and/or ⁇ -opioid receptor.
  • a particular receptor for example the CBl, CB2 GPR55, 5HT-1A, 5HT-2A, TRPV1, and/or ⁇ -opioid receptor.
  • compositions disclosed herein change the EC50 of THC at the CBl receptor.
  • the EC50 of THC is modulated, thereby providing new beneficial properties.
  • THC activity at the CBl receptor has a consistent EC50 of about 1 micromolar and a 40 - 50% amplitude of response compared to a known, synthetic full agonist (e.g., CP-55,940).
  • the synergistic benefits of the compositions disclosed herein can be demonstrated by measuring the EC50 of THC at CBl alone and then comparing it to the EC50 of THC at CBl in the presence of other cannabinoids and terpenes.
  • the disclosed compositions provide a synergistic effect relative to a reference cannabinoid administered alone. In one example, the disclosed compositions add to the effects of a reference cannabinoid. In one example, the disclosed compositions compete with a reference cannabinoid at the CB 1 receptor.
  • the disclosed compositions provide a synergistic effect relative to THC alone. In one example, the disclosed compositions add to the effects of THC alone.
  • compositions disclosed herein provide for methods of increasing the response of THC at the CBl receptor (relative to THC alone) comprising administering THC in concert with a terpene.
  • the purified terpene is chosen from Limonene, Nerolidol, Beta- Myrcene, Linalool, Alpha-Caryophyllene, Beta-Caryophyllene, Alpha-Pinene, Beta-Pinene, Alpha-Bisabolol, Delta-3-Carene, Borneol, p-Cymene, Eucalyptol, Alpha-Humulene, Alpha- Terpineol, Terpinolene, Pulegone, Camphene, or Geraniol.
  • a receptor e.g. CB1, CB2 GPR55, 5HT-1A, 5HT-2A, TRPV1, serotonin receptor, ⁇ -opioid receptor, etc.
  • increasing the potency at a receptor comprises a second purified cannabinoid.
  • increasing the potency at a receptor comprises a second purified terpene.
  • compositions disclosed herein provide methods of increasing the response of THC at the CB 1 receptor (relative to THC alone) comprising administering THC in concert with a terpene.
  • the method of increasing THC potency comprises administering THC in concert with alpha-humulene.
  • the method of increasing THC potency comprises administering THC in concert with linalool.
  • the method of increasing THC potency comprises administering THC in concert with nerolidol.
  • the method of increasing THC potency comprises administering THC in concert with limonene.
  • the method of increasing THC potency comprises administering THC in concert with alpha-terpineol.
  • the method of increasing THC potency comprises administering THC in concert with beta-pinene. In one example the method of increasing THC potency comprises administering THC in concert with p-cymene. In one example the method of increasing THC potency comprises administering THC in concert with eucalyptol.
  • compositions disclosed herein provide methods of increasing the response of THC at the CB 1 receptor (relative to THC alone) comprising administering THC in concert with a second cannabinoid.
  • the method of increasing THC potency comprises administering THC in concert with CBC.
  • the method of increasing THC potency comprises administering THC in concert with CBG.
  • the method of increasing THC potency comprises administering THC in concert with THCV.
  • the method of increasing THC potency comprises administering THC in concert with CBD.
  • the disclosed compositions compete with THC at the CB 1 receptor.
  • the EC50 of THC at CB1 is decreased (relative to THC alone) by formulating a composition comprising purified THC and a purified terpene chosen from Limonene, Nerolidol, Beta-Myrcene, Linalool, Alpha-Caryophyllene, Beta-Caryophyllene, Alpha-Pinene, Beta-Pinene, Alpha-Bisabolol, Delta-3-Carene, Borneol, p-Cymene, Eucalyptol, Alpha-Humulene, Alpha-Terpineol, Terpinolene, Pulegone, Camphene, or Geraniol.
  • a purified terpene chosen from Limonene, Nerolidol, Beta-Myrcene, Linalool, Alpha-Caryophyllene, Beta-Caryophyllene, Alpha-Pinene, Beta-Pinene, Alpha-Bisabolol, Delta-3-Caren
  • the EC50 of THC at CB1 is increased (relative to THC alone) by formulating a composition comprising purified THC and beta-caryophyllene.
  • a composition comprising purified THC and beta-caryophyllene.
  • the phrase "comprising a purified THC and a purified terpene” means that the composition includes between about 0.5% to about 10% combined terpene content.
  • An exemplary non-limiting terpene is linalool.
  • One embodiment of this disclosure comprises 0.5-1% purified linalool.
  • One embodiment of this disclosure comprises 1-2% purified linalool.
  • One embodiment of this disclosure comprises 2-5% purified linalool.
  • One embodiment of this disclosure comprises 5-10% purified linalool.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Limonene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Nerolidol.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Beta-Myrcene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Linalool.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Alpha-Caryophyllene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Beta-Caryophyllene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Alpha-Pinene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Beta-Pinene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Alpha-Bisabolol.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Delta-3-Carene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Borneol.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Eucalyptol.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Alpha-Terpineol.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified p-Cymene. In one example, the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Alpha-Humulene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Terpinolene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Pulegone.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Camphene.
  • the EC50 of THC at CB1 is decreased by formulating a composition comprising purified THC and purified Geraniol.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at CB1. In one example, the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at GPR55. In one example, the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions increase the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB1 while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at CB1. In one example, the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at CB2 while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at GPR55 while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at GPR55. In one example, the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while increasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-1A while decreasing the EC50 of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while increasing the EC50 of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at CB1.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at CB2.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the EC50 of a first cannabinoid at 5HT-2A while decreasing the EC50 of a second cannabinoid at 5HT-1A.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating a composition comprising purified THC and purified Limonene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating a composition comprising purified THC and purified Nerolidol.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating a composition comprising purified THC and purified Beta-Myrcene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating a composition comprising purified THC and purified Linalool.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating a composition comprising purified THC and purified Alpha-Caryophyllene. In one example, the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Beta-Caryophyllene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Alpha-Pinene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Beta-Pinene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Alpha-Bisabolol.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Delta-3-Carene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Borneol.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Eucalyptol.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Alpha-Terpineol.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified p-Cymene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Alpha-Humulene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Terpinolene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Camphene.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Geraniol.
  • the Amplitude of Response of THC at CB 1 is decreased by formulating composition comprising purified THC and purified Pulegone.
  • the Amplitude of Response of THC at CBl is increased by formulatinj composition comprising purified THC and purified Limonene.
  • the Amplitude of Response of THC at CBl is increased by formulatinj composition comprising purified THC and purified Nerolidol.
  • the Amplitude of Response of THC at CBl is increased by formulatinj composition comprising purified THC and purified Beta-Myrcene.
  • the Amplitude of Response of THC at CBl is increased by formulatinj composition comprising purified THC and purified Linalool. In one example, the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Alpha-Caryophyllene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Beta-Caryophyllene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Alpha-Pinene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Beta-Pinene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Alpha-Bisabolol.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Delta-3-Carene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Borneol.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Eucalyptol.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Alpha-Terpineol.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified p-Cymene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Alpha-Humulene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Camphene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Terpinolene.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Geraniol.
  • the Amplitude of Response of THC at CB 1 is increased by formulating a composition comprising purified THC and purified Pulegone.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CBl while increasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CBl while increasing the Amplitude of Response of a second cannabinoid at GPR55. In one example, the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB 1 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 1A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB 1 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 1A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at CB 1. In one example, the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 1A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at CB 1.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 1A. In one example, the disclosed compositions increase the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at GPR55. In one example, the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at 5HT-2A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at 5HT-1A.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at GPR55. In one example, the disclosed compositions increase the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CBl while increasing the Amplitude of Response of a second cannabinoid at CB2. In one example, the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CBl while increasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB 1 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 1A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB 1 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 2A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 1A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CBl while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 2A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at CB 1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 1A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while increasing the Amplitude of Response of a second cannabinoid at 5HT- 2A. In one example, the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at CB 1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 1A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at CB2 while decreasing the Amplitude of Response of a second cannabinoid at 5HT- 2A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while increasing the Amplitude of Response of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at 5HT-1A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at GPR55 while decreasing the Amplitude of Response of a second cannabinoid at 5HT-2A. In one example, the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while increasing the Amplitude of Response of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-1A while decreasing the Amplitude of Response of a second cannabinoid at 5HT-2A.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while increasing the Amplitude of Response of a second cannabinoid at 5HT-1A. In one example, the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at CB1.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at CB2.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at GPR55.
  • the disclosed compositions decrease the Amplitude of Response of a first cannabinoid at 5HT-2A while decreasing the Amplitude of Response of a second cannabinoid at 5HT-1A.
  • the EC50 of THC at CB1 is decreased within a composition comprising THC and Alpha-Humulene.
  • the EC50 of THC at CB 1 is decreased to between about 0.1 micromolar to about 0.5 micromolar.
  • the EC50 of THC at CB1 is decreased within a composition comprising THC and Linalool.
  • the EC50 of THC at CB 1 is decreased to between about 0.05 micromolar to about 0.2 micromolar.
  • the term "cannabinoid” refers to a compound belonging to a class of secondary compounds commonly found in plants of genus cannabis.
  • the cannabinoid is found in a plant, e.g., a plant of genus cannabis, and is sometimes referred to as a phytocannabinoid.
  • the cannabinoid is found in a mammal, sometimes called a endocannabinoid.
  • the cannabinoid is made in a laboratory setting, sometimes called a synthetic cannabinoid.
  • the cannabinoid acts upon a cellular receptor, such as a G-coupled protein receptor (e.g., a serotonin receptor, a cannabinoid receptor, TRPV1, an opioid receptor, etc.) thereby causing a response on the brain or body.
  • a G-coupled protein receptor e.g., a serotonin receptor, a cannabinoid receptor, TRPV1, an opioid receptor, etc.
  • the cannabinoid affects the activity of other compounds at one or more receptors by acting as an agonist, partial agonist, inverse agonist, antagonist, etc.
  • a cannabinoid can be identified because its chemical name will include the text string "*cannabi* in the name.
  • each of the acid and/or decarboxylated forms are contemplated as both single molecules and mixtures.
  • cannabinoids include, but are not limited to, Cannabigerolic Acid (CBGA), Cannabigerolic Acid monomethylether (CBGAM), Cannabigerol (CBG), Cannabigerol monomethylether (CBGM), Cannabigerovarinic Acid (CBGVA), Cannabigerovarin (CBGV), Cannabichromenic Acid (CBCA), Cannabichromene (CBC), Cannabichromevarinic Acid (CBCVA), Cannabichromevarin (CBCV), Cannabidiolic Acid (CBDA), Cannabidiol (CBD), Cannabidiol monomethylether (CBDM), Cannabidiol-C4 (CBD-C4), Cannabidivarinic Acid (CBDVA), Cannabidivarin (CBDV), Cannabidiorcol (CBD-Ci), Tetrahydrocannabinolic acid A (THCA-A), Tetrahydrocannabinolic acid B
  • the purified cannabinoid is chosen from THC, D9-THC, D8-THC, THCA, THCV, D8-THCV, D9-THCV, THCVA, CBD, CBDA, CBDV, CBDVA, CBC, CBCA, CBCV, CBCVA, CBG, CBGA, CBGV, CBGVA, CBN, CBNA, CBNV, CBNVA, CBND, CBNDA, CBNDV, CBNDVA, CBE, CBEA, CBEV, CBEVA, CBL, CBLA, CBLV, or CBLVA.
  • THC tetrahydrocannabinol and has the following structural formula:
  • compositions comprising THC are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • THCA tetrahydrocannabinolic acid and has the following structural formula:
  • compositions comprising THCA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • THCV tetrahydrocannabivarin
  • compositions comprising THCV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • THCVA tetrahydrocannabivarinic acid and has the following structural formula:
  • THCVA Decarboxylating THCVA with heat, light, etc., forms THCV, D8-THCV, D9-THCV, and other possible cannabinoid derivatives.
  • compositions comprising THCVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • D8-THC refers to delta- 8-tetrahydrocannabinol and has the following structural formula:
  • compositions comprising D8-THC are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • D8-THCV refers to delta-8-tetrahydrocannabivarin and has the following structural formula:
  • compositions comprising D8-THCV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • D9-THC refers to delta-9-tetrahydrocannabinol and has the following structural formula:
  • compositions comprising D9-THC are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • D9-THCV refers to delta-9-tetrahydrocannabivarin and has the following structural formula:
  • compositions comprising D9-THCV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBD cannabidiol and has the following structural formula:
  • compositions comprising CBD are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBDA cannabidiolic acid and has the following structural formula:
  • compositions comprising CBDA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBDV cannabidivarin and has the following structural formula:
  • CBDV cannabidivarinic acid
  • compositions comprising CBDVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBC cannabichromene and has the following structural formula:
  • compositions comprising CBC are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBCA cannabichromenic acid and has the following structural formula:
  • compositions comprising CBCA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBCV cannabichromevarin and has the following structural formula:
  • compositions comprising CBCV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBCVA cannabichromevarinic acid and has the following structural formula:
  • compositions comprising CBCVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBG cannabigerol and has the following structural formula:
  • compositions comprising CBG are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBGA cannabigerolic acid and has the following structural formula:
  • compositions comprising CBGA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBGV cannabigerovarin and has the following structural formula:
  • compositions comprising CBGV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBGV A refers to cannabigerovarinic acid and has the following structural formula:
  • compositions comprising CBGVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBN cannabinol and has the following structural formula:
  • compositions comprising CBN are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBNA cannabinolic acid and has the following structural formula:
  • compositions comprising CBNA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBNV cannabivarin and has the following structural formula:
  • compositions comprising CBNV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBNVA cannabivarinic acid and has the following structural formula:
  • compositions comprising CBNVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBND refers to cannabinodiol and has the following structural formula:
  • compositions comprising CBND are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity,
  • CBNDA cannabinodiolic acid and has the following structural formula:
  • compositions comprising CBNDA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBNDV cannabivarinodiol and has the following structural formula:
  • compositions comprising CBNDV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBNDVA refers to cannabivarinodiolic acid and has the following structural formula:
  • compositions comprising CBNDVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBL cannabicyclol and has the following structural formula:
  • compositions comprising CBL are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBLA cannabicyclolic acid and has the following structural formula:
  • compositions comprising CBLA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBLV refers to cannabicyclovarin and has the following structural formula:
  • compositions comprising CBLV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBLVA refers to cannabielvarinsoinic acid and has the following structural formula:
  • compositions comprising CBLVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBE cannabielsoin and has the following structural formula:
  • compositions comprising CBE are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBEA cannabielsoic acid and has the following structural formula:
  • compositions comprising CBEA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBEV refers to cannabivarinselsoin and has the following structural formula:
  • compositions comprising CBEV are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • CBEVA refers to cannabivarinselsoinic acid and has the following structural formula:
  • compositions comprising CBEVA are formulated with other compounds, thereby providing previously unavailable potency, control, consistency, purity, etc.
  • terpene refers to a compound built on an isoprenoid structure or produced by combining isoprene units, 5 carbon structures. Terpenes are also associated with producing smell in plants where terpenes are part of a class of secondary compounds.
  • the terpene is a hydrocarbon.
  • the term “terpene” does not necessarily require 5 carbons or multiples of 5 carbons. It is understood that a reaction with isoprene units does not always result in a terpene comprising all the carbon atoms.
  • terpene includes Hemiterpenes, Monoterpenols, Terpene esters, Diterpenes, Monoterpenes, Polyterpenes, Tetraterpenes, Terpenoid oxides, Sesterterpenes, Sesquiterpenes, Norisoprenoids, or their derivatives. As well as isomeric, enantiomeric, or optically active derivatives.
  • terpenes include terpenoids, hemiterpenoids, monoterpenoids, sesquiterpenoids, sesterterpenoid, sesquarterpenoids, tetraterpenoids, triterpenoids, tetraterpenoids, polyterpenoids, isoprenoids, and steroids.
  • terpene includes the a- (alpha), ⁇ - (beta), ⁇ - (gamma), oxo-, isomers, or any combinations thereof.
  • terpenes within the context of this disclosure include: 7,8-dihydro-alpha- ionone, 7,8-dihydro-beta-ionone, Acetanisole, Acetic Acid, Acetyl Cedrene, Anethole, Anisole, Benzaldehyde, Bergamotene (Alpha-cis-Bergamotene) (Alpha-trans-Bergamotene), Bisabolol (Beta-Bisabolol), Alpha Bisabolol, Borneol, Bornyl Acetate, Butanoic/ Butyric Acid, Cadinene (Alpha-Cadinene) (Gamma-Cadinene), cafestol, Caffeic acid, Camphene, Camphor, Capsaicin, Carene (Delta-3-Carene), Carotene, Carvacrol, Dextro-Carvone, Laevo-Carvone, Alpha- Caryophyllene
  • 7,8-dihydro-alpha-ionone is often characterized as having a woody, floral odor.
  • 7,8-dihydro-beta-ionone is often characterized as having a woody aroma.
  • acetanisole refers to a compound with the following structural formula:
  • Acetanisole is often characterized as having a sweet, anisic, vanilla-like aroma with powdery, balsamic, and benzaldehyde nuances. Acetanisole is also used as a flavoring agent.
  • acetic acid refers to a compound with the following structural formula:
  • Acetic acid is often characterized as a one of the main constituents of vinegar.
  • acetyl cedrene refers to a compound with the following structural formula:
  • Acetyl cedrene is often characterized as having a warm, woody, amber musky aroma. Acetyl cedrene is also a fragrance agent.
  • anethole refers to an aromatic compound having the following structural formula:
  • Anethole is often characterized as having a sweet, anise, licorice aroma. Anethole is used in a wide variety of fragrances and flavors.
  • anisole refers to a compound with the following structural formula:
  • Anisole is often characterized as smelling like anise seeds.
  • benzaldehyde refers to a compound with the following structural formula:
  • Benzaldehyde is often characterized as having an almond-like odor.
  • bergamotene refers to a compound including either or both alpha-cis-bergamotene and/or alpha-trans-Bergamotene in a pure and/or mixture of any ratio.
  • Alpha-cis-bergamotene refers to a com ound with the following structural formula:
  • Alpha-cis-bergamotene is often characterized as having a strong odor of ground black pepper.
  • Alpha-cis-bergamotene is an aroma component of many species of the family orchidaceae.
  • Alpha-trans-Bergamoten refers to the following structural formula:
  • Alpha-trans-Bergamotene is often characterized as having a medium strength, warm, tea- leaf-like odor. Alpha-trans-Bergamotene is used in the chemical communication system of some species of aphids.
  • bisabolol refers to a compound including either or both of alpha bisabolol and/or beta bisabolol in a pure and/or mixture of any ratio.
  • Alpha-bisabolol refers to a compound with the following structural formula:
  • Alpha-bisabolol is often characterized as the active component of chamomile.
  • Beta-bisabolol refers to a compound with the following structural formula:
  • Beta-bisabolol is often characterized as having a citrus, floral, lemon, sweet, herbaceous aroma.
  • borneol refers to a compound having the following structural formula:
  • Borneol is often characterized as having a menthol aroma, similar to camphor. Borneol can also be converted into camphor.
  • bornyl acetate refers to a compound with the following structural formula:
  • Bomyl acetate is often characterized as having a pine, camphoraceous, herbal, and balsamic odor.
  • butanoic/butyric acid refers to a compound with the following structural formula:
  • Butyric acid is often characterized as having an unpleasant, acrid odor normally found in perspiration, flatulence, and rancid butter.
  • cadinene refers to a compound including either or both of alpha- cadinene and/or gamma-cadinene in a pure and/or mixture of any ratio.
  • Alpha-cadinene refers to a comp formula:
  • -cadinene is often characterized as having a pungent, smoky, woody, guaiac wood-like odor.
  • Gamma-cadinene refers to a compound having either of the following structural formula:
  • Gamma-cadinene is often characterized as having an herbaceous, herbal, woody aroma.
  • Gamma- cadinene has shown some antimicrobial and antibacterial properties. Many species of termites and a few beetles utilize gamma-cadinene in their chemical communication systems.
  • caffeineic acid refers to a compound with the following structural formula:
  • Caffeic acid is often characterized as a key intermediate in the synthesis of lignin.
  • camphene refers to a compound with the following structural formula:
  • Camphene is often characterized as having a pungent, herbal, fir needle smell. Camphene is used in fragrances and food additives. Camphene is a minor constituent of many essential oils such as turpentine, cypress oil, camphor oil, citronella oil, neroli, ginger oil, and valerian.
  • camphor refers to a compound with either of the following structural formulas:
  • camphor includes enantiomers as either a single form or a mixture in any ratio. Camphor has a very characteristic odor for which the tree is named. Camphor is used as a flavor and fragrance agent in chewing gum, hard candy, etc.
  • capsaicin refers to a chemical compound with following structural formula:
  • Capsaicin is often odorless. Capsaicin is often characterized as an irritant for mammals, known for the sensation it provokes when inhaled, eaten, or applied to the skin.
  • carene or “delta-3 -carene” refers to a compound with the following structural formula:
  • Delta-3 -carene sometimes referred to as "Carene” is often characterized as having a sweet and pungent odor.
  • carbotene refers to any one of a series of related compounds having the chemical formula C/toHx.
  • carotene refers to any of the isomeric forms of carotene in a pure and/or mixture in any ratio. Carotene is often characterized as an important compound in the photosynthesis process.
  • carvacrol refers to a compound with the following structural formula:
  • Carvacrol is often characterized as having a pungent odor of oregano.
  • Carvacrol is often used as a flavor and fragrance agent and its flavor has been described as spicy, herbal, phenolic, medicinal, and woody.
  • the term “dextro-carvone” refers to the S-(+) enantiomer of carvone with the following structural formula:
  • Dextro-carvone is often characterized as having a spicy, bready, caraway aroma. Dextro-carvone is found in mandarin peel oil and gingergrass oil. Dextro-carvone is the principal constituent of the oil from caraway seeds.
  • laevo-carvone refers to the R-(-) enantiomer of carvone with the following structural formula:
  • Laevo-carvone is often characterized as having a sweet, minty, herbaceous, spearmint odor. Laevo- carvone is found in spearmint and kuromoji oils.
  • beta-caryophyllene refers to a compound with the following structural formula:
  • Beta-Caryophyllene is often characterized as a flavor component of black pepper. Beta- caryophyllene is often referred to as caryophyllene.
  • caryophyllene oxide refers a compound with the following structural formula:
  • Caryophyllene oxide is often characterized as having a lemon balm odor.
  • cedrene refers to either or both of alpha-cedrene and/or beta- Cedrene as pure forms or mixtures in any ratio.
  • Alpha-cedrene refers to a compound having the following structural formula:
  • Alpha-cedrene is often characterized as having a medium strength, woody, sweet, fresh aroma of cedar.
  • Alpha-cedrene is used in bakery items, sherbet and sorbet.
  • Alpha-cedrene is a major component in the essential oil of cedar.
  • Beta-cedrene refers to a compound with the following structural formula:
  • Beta-cedrene is often characterized as having a woody aroma of cedar. Beta-cedrene is a major component in the essential oil of cedar.
  • cedrene epoxide or "alpha-cedrene epoxide” refers to a compound with the following structural formula:
  • Alpha-cedrene epoxide is often characterized as having a woody, amber, tobacco, sandalwood, and fresh patchouli aroma. Alpha-cedrene epoxide is commonly used as a fragrance agent and a perfuming agent for cosmetics.
  • cedrol refers to a compound with the following structural formula:
  • Cedrol is often characterized as having a very faint aroma that is sweet, cedar, and woody. Cedrol is a major component of cedar wood oil.
  • Cembrene A is often characterized as having a faint wax like odor.
  • chlorogenic acid refers to a compound with the following structural formula:
  • Chlorogenic acid can often be found in peaches, prunes, and green coffee bean extract.
  • Cinnamaldehyde is often characterized as having a spicy, sweet cinnamon odor, and gives cinnamon its flavor. Cinnamaldehyde occurs naturally in the bark of cinnamon trees and other species of the genus Cinnamomum.
  • alpha-hexyl-cinnamaldehyde refers to a compound with the following structural formula:
  • Alpha-hexyl-cinnamaldehyde is often characterized as having a sweet, floral, green, jasmine, citrus, and fruity aroma with powdery, tropical or spicy notes.
  • alpha-amyl-cinnamaldehyde refers to a compound with the following structural formula:
  • Alpha-amyl-cinnamaldehyde is often characterized as having a sweet, floral, fruity, herbal, jasmine, and tropical aroma.
  • Cinnamic acid is often characterized as having a balsamic, sweet, storax, honey-like odor. Cinnamic acid is obtained from the oil of cinnamon or from balsams such as storax.
  • cinnamyl alcohol refers to a compound with the following structural formula:
  • Cinnamyl alcohol is often characterized as having a cinnamon spice, floral green, and fermented odor with powdery balsamic nuances.
  • a flavor component cinnamyl alcohol has a green, floral, spicy, and honey flavor with a fermented yeasty nuance.
  • citronellal refers to a compound with the following structural formula:
  • Citronellal is often characterized as making up to 80% of the leaf oil from Kaffir lime leaves and as the characteristic aroma.
  • chromenellol refers to either or both of the (+) and (-) enantiomers as pure forms or mixtures in any ratio.
  • the (+) enantiomer has the following structural formula:
  • the (-) form has the followin structural formula:
  • Citronellol is often characterized as having a floral, rosy, sweet, citrus with green, fatty, terpene- nuanced odor.
  • Cryptone is often characterized as having a woody minty herbaceous smell.
  • curcumene refers either or both alpha-curcumene and/or gamma-curcumene as pure forms or mixtures in any ratio.
  • Alpha-curcumene has the following structural formula:
  • Alpha-curcumene is often characterized as having an odor similar to turmeric. Alpha-curcumene is found prominently in the Zingiber genus of ginger.
  • Gamma-curcumene has the following structural formula:
  • Gamma-curcumene is often characterized as having an earthy aroma. Gamma-curcumene is found prominently in the Libocedrus bidwillii tree.
  • Decanal is often characterized as having a citrus odor. Decanal is used as a fragrance and flavoring agent.
  • dehydrovomifoliol refers to a compound with the following structural formula:
  • Dehydrovomifoliol is often characterized as having a fruity and flowery odor.
  • diallyl disulfide refers to a compound with the following structural formula:
  • Diallyl disulfide is often characterized as having a strong, alliaceous, onion, and garlic-like odor.
  • dihydroactinidiolide refers to a compound with the following structural formula:
  • Dihydroactinidiolide is often characterized as having a fruity, musky, coumarin tea-like, peach aroma.
  • dimethyl disulfide refers to a compound with the following structural formula:
  • Dimethyl disulfide is often characterized as having a sulfurous, rotten aroma.
  • eicosane or “icosane” refers to a compound with the chemical formula C20H42 and having 366,619 constitutional isomers with the following skeletal structure:
  • Eicosane is often characterized as having a waxy odor. Eicosane is used in fragrance concentrates.
  • beta-elemene refers to a compound with the following structural formula:
  • Beta-elemene is often characterized as having a sweet aroma.
  • estragole refers to a compound with the following structural formula:
  • Estragole is an isomer of anethole. Estragole is often characterized as having an anise seed smell and occurs in tarragon oil, turpentine, and other essential oils.
  • ethyl acetate refers to a compound with the following structural formula:
  • Ethyl acetate is often characterized as having an acidic, fruity, dirty, cheesy, fermented odor.
  • ethyl cinnamate refers to a compound with the following structural formula:
  • Ethyl Cinnamate is often characterized as having a sweet, balsamic, spicy, fruity, berry, and plum odor.
  • ethyl maltol refers to a compound with the following structural formula:
  • Ethyl maltol is often characterized as having a sweet smell similar to caramelized sugar and cooked fruit.
  • eucalyptol refers to a terpene with the following structural formula:
  • Eucalyptol is often characterized as having a mint-like smell. Eucalyptol is also known by 1,8- cineol, 1,8-cineole, cajeputol, 1,8-epoxy-p-menthane, 1,8-oxido-p-menthane, eucalyptol, eucalyptole, l,3,3-trimethyl-2-oxabicyclo[2,2,2]octane, cineol, and cineole.
  • eudesmol refers to alpha-eudesmol, beta-eudesmol, or gamma- eudesmol as pure forms or mixtures in any ratio.
  • Alpha-eudesmol is often characterized as having a sweet, woody odor.
  • Beta-eudesmol has the following structural formula:
  • Beta-eudesmol is often characterized as having a sweet, green, woody, yuzu-like aroma.
  • Gamma-eudesmol is often characterized as having a waxy, sweet, woody, floral odor.
  • Euphol is often characterized as the main constituent in the sap of Euphorbia tirucalli.
  • farnesene refers to six closely related compounds.
  • E, E)-alpha- farnesene is one of these six molecules and has the following structural formula:
  • farnesene refers to any one of the six closely related compounds, either alone or in combination of any other of those six closely related compounds.
  • Farnesene is often characterized as having a fragrance of magnolia flowers and has citrus notes with green, woody, vegetative odor with hints of lavender.
  • Farnesol is often characterized as having a mild, fresh, sweet, floral, linden tree odor. Farnesol is used in cosmetics, flavors and fragrances.
  • fenchol or "beta-fenchol” refers to a compound with the following structural formula:
  • Beta-fenchol is often characterized as having a camphorous, piney, woody, dry, sweet, lemon scent. Beta-fenchol is used as a flavor and fragrance agent.
  • Fenchone is often characterized as having a camphorous, thuja, cedar leaf, herbal, earthy, woody aroma.
  • Geraniol is often characterized as having a sweet-rose like scent.
  • the term "geranyl acetate” refers to a compound with the following structural formula:
  • Geranyl acetate is often characterized as having a floral and fruit aroma. Geranyl acetate is found in a variety of natural oils from plants such as citronella, lemon grass, sassafras, rose, and many others.
  • geranylfarnesol refers to a compound with the following structural formula:
  • Geranylfarnesol is often characterized as a clear colorless liquid.
  • the term “germacrene” refers to a class of hydrocarbons. Within the context of this disclosure, the term “germacrene” refers to any of the five isomers as either pure forms or in any combination of the five isomers.
  • Germacrene A refers to the following structural formula:
  • Germacrene B refers to the followin structural formula:
  • Germacrene C refers to the following structural formula:
  • Germacrene D refers to the followin structural formula:
  • Germacrene E refers to the following structural formula:
  • guaia- 1(10), 11 -diene refers to a compound with the following structural formula:
  • Guaia- 1 ( 10), 11 -diene is often characterized as having a sweet, woody aroma. Guaia- 1 ( 10), 11 -diene is used as a fragrance for a wide range of products from food additives, tobacco flavorings and general cosmetics, to odorizing rooms.
  • guaiacol refers to a compound with the following structural formula:
  • Guaiacol is often characterized as having a smoke-like, spicy, woody, medicinal odor. Guaiacol has a sweet, powdery, musty, vanilla, floral, almond flavor.
  • alpha-guaiene refers to a compound with the following structural formula:
  • Alpha-guaiene is often characterized as having a sweet, earthy, woody, balsamic, peppery aroma.
  • gurjunene or "alpha-gurjunene” refers to a compound with the following structural formula:
  • Alpha-gurjunene is often characterized as having a woody, balsamic odor. Alpha-gurjunene is used in cosmetics and fragrances.
  • Herniarin is often found in Herniaria glabra, Ayanpana triplinervis, and in species of the genus Prunus (P. mahaleb, P. pensylvanica, and P. maximowiczil).
  • Prunus P. mahaleb, P. pensylvanica, and P. maximowiczil.
  • hexanaldehyde refers to a compound with the following structural formula:
  • Hexanaldehyde is often characterized as having a grassy odor. Hexanaldehyde is also called hexanal.
  • hexanoic acid refers to a compound with the following structural formula:
  • Hexanoic acid is often characterized as having a pungent, acrid, sour, fatty, sweaty, rancid cheese odor.
  • alpha-humulene refers to a compound with the following structural formula:
  • Alpha-humulene is often characterized as contributing to the flavor profile of beer.
  • Alpha- humulene is sometimes often referred to as simply "Humulene” or “Caryophyllene” and in the context of this disclosure both may be used interchangeably.
  • beta-humulene refers to a compound with the following structural formula:
  • Beta-humulene is often characterized as having a green aroma.
  • lonol is also known as Butylated Hydroxy Toluene (BHT).
  • BHT Butylated Hydroxy Toluene
  • ionol also refers to 3-oxo-alpha-ionol and/or beta-ionol in a pure and/or mixture of any ratio, lonol is often characterized as having a sweet, woody, herbal, fruity, floral, tropical, and berry aroma.
  • ionone refers to either or both alpha-ionone and/or beta-ionone as pure forms or mixtures in any ratio.
  • Alpha-ionone refers to the following structural formula:
  • Beta-ionone refers to the following structural formula:
  • Alpha-ionone and beta-ionone as a mixture have an aroma similar to the violet flower.
  • ipsdienol refers to a compound with the following structural formula:
  • Ipsdienol is often characterized as having a balsamic, piney aroma.
  • isoamyl acetate refers to a compound with the following structural formula:
  • Isoamyl acetate is often characterized as having an odor similar to banana and pears.
  • isoamyl alcohol refers to a compound with the following structural formula:
  • Isoamyl alcohol is often characterized as having a pungent, fermented, fusel, alcohol-like, aroma with fruity, banana and molasses notes. Isoamyl alcohol is used as a flavor and fragrance agent.
  • isoamyl formate refers to a compound with the following structural formula:
  • Isoamyl formate is often characterized as having a vinous, dry, earthy, fruity, green, plum, and blackcurrant aroma.
  • isoborneol refers to a compound with the following structural formula:
  • Isoborneol is often characterized as having a camphoraceous, sweet & musty aroma.
  • isomyrcenol refers to a compound with the following structural formula:
  • Isomyrcenol is often characterized as having a fresh, floral, lime-like odor. Isomyrcenol is used in the chemical communication systems of beetles.
  • isopulegol refers to a compound with the following structural formula:
  • Isopulegol is often characterized as having a medium strength odor that is minty, cooling and bittersweet.
  • isopulegol may also refer to any number of isomeric forms.
  • isovaleric acid refers to a compound with the following structural formula:
  • Isovaleric acid is often characterized as having a strong, pungent, sour, and sweaty cheese smell. Isovaleric acid is also known as 3-methylbutanoic acid.
  • isoprene refers to a compound with the following structural formula:
  • Isoprene is often considered as a building block for many other terpenes.
  • kahweol refers to a compound with the following structural formula:
  • lavender refers to either the R and S enantiomers as pure forms or mixture in any ratio with the following structural formula:
  • Lavandulol is often found in the essential oil of lavender.
  • limonene refers to a terpene with the following structural formula:
  • Limonene is often characterized as having a smell similar to oranges and other citrus fruits.
  • the term “Limonene” encompasses all possible enantiomers and isomers of the compound in as either individual compounds or in a racemic mixture.
  • gamma-linolenic acid refers to a compound with the following structural formula:
  • Gamma-linolenic acid is often characterized as an unsaturated fatty acid found primarily in vegetable oils.
  • Linalool refers to a ter ene with the following structural formula:
  • Linalool has two known enantiomeric forms.
  • (S)-(+)-Linalool is often characterized as sweet and floral and the (R)-form is more woody and lavender-like.
  • the "Linalool” refers to either of the enantiomers or a racemic mixture of the two.
  • longifolene refers to a compound having both (+) and (-) enantiomers.
  • (+) enantiomer refers to the following structural formula:
  • longifolene refers to either of its (+) and/or (-) enantiomers in a pure form or mixture in any ratio. Longifolene is often characterized as having a sweet, woody, rosy, medical, fir needle odor.
  • alpha-longipinene refers to a compound with the following structural formula:
  • Alpha-longipinene is often characterized as having a pine aroma.
  • lycopene refers to a compound with the following structural formula:
  • Lycopene is often characterized for its red color.
  • luteolin refers to a compound with the structural formula:
  • Luteolin is often found in leaves, rinds, barks, clover blossoms, and ragweed pollen.
  • menthol refers to a compound with the following structural formula:
  • Menthol is often characterized as having a cooling, minty, peppermint aroma and flavor. Menthol is obtained from cornmint, peppermint or other mint oils.
  • methyl butyrate refers to a compound with the following structural formula:
  • Methyl butyrate is often characterized as having a sulfurous odor.
  • 3-Mercapto-2-Methylpentanal refers to a compound with the following structural formula:
  • 3-Mercapto-2-Methylpentanal is often characterized as having a sulfurous, alliaceous, garlic odor.
  • 3-Mercapto-2-Methylpentanol refers to a compound with the following structural formula:
  • 3-Mercapto-2-Methylpentanol is often characterized as having a very strong, sulfurous, onion type aroma.
  • mercaptan refers to an organosulfur compound containing a carbon-bonded sulfhydryl. Mercaptan is often characterized as the main odor constituent added to assist in the detection of natural gas (which in pure form is odorless), and the "smell of natural gas” is due to the smell of the mercaptan thiol used as the odorant. Mercaptan is also referred to as thiol.
  • beta-mercaptoethanol refers to a compound with the following structural formula:
  • Beta-mercaptoethanol is often characterized as having an extremely strong and persistent aroma of sulfur.
  • mercaptoacetic acid refers to a compound with the following structural formula:
  • Mercaptoacetic acid is often characterized as having an ugly, sharp, acrid, skunk smell with plenty of endurance. Mercaptoacetic acid is also referred to as thioglycolic acid.
  • allyl mercaptan refers to a compound with the following structural formula:
  • Allyl mercaptan is often characterized as having a strong sulfurous and alliaceous aroma.
  • benzyl mercaptan refers to a compound with the following structural formula:
  • Benzyl mercaptan is often characterized as having a strong, sharp, alliaceous, sulfurous, onion, garlic, and horseradish aroma.
  • butyl mercaptan refers to a compound with the following chemical formula C4H10S.
  • the butyl mercaptan has the following structural formula:
  • Butyl mercaptan is often characterized as having an extremely strong foul-smelling odor, commonly described as "skunk” odor.
  • methyl mercaptan refers to a compound with the following structural formula:
  • Methyl mercaptan is often characterized as having an extremely strong, sulfurous, decomposing cabbage, skunky aroma. Methyl mercaptan is also called methanethiol.
  • furfuryl mercaptan refers to a compound with the following structural formula:
  • Furfuryl mercaptan is often characterized as having a very strong, oily, fatty, sulfurous, skunky odor.
  • ethylene mercaptan refers to a compound with the following structural formula:
  • Ethylene mercaptan is often characterized as having a very high strength, sulfurous, skunky odor.
  • propyl mercaptan refers to a compound with the following structural formula:
  • Propyl mercaptan is often characterized as having a high strength, alliaceous, natural gas, sweet onion, cabbage odor. Propyl mercaptan is also referred to as propanethiol.
  • thenyl mercaptan refers to a compound with the following structural formula:
  • yl mercaptan is often characterized as having a strong roast coffee, fishy aroma. Thenyl mercaptan is used as a flavoring agent mimicking the flavor of coffee.
  • methyl salicylate refers to a compound with the following structural formula:
  • Methyl salicylate is often characterized as having a strong, distinct wintergreen aroma. Methyl salicylate is used as a fragrance agent, a food and beverage agent.
  • methylbutenol refers to a compound with the following structural formula:
  • Methylbutenol is often characterized as having a very strong, malty herb aroma. Methylbutenol is released in high concentrations from lodgepole pine trees.
  • methyl-2-methylvalerate refers to a carboxylic acid with the following structural formula:
  • Methyl-2-methylvalerate is often characterized as having a fruity, sweet, berry, pineapple, apple, banana, green melon, and tropical aromas.
  • methyl thiobutyrate refers to a compound with the following structural formula:
  • Methyl thiobutyrate is often characterized as a flavoring and food agent.
  • beta-myrcene refers to a terpene with the following structural formula:
  • Beta-Myrcene is often characterized as having an earthy, fruity clove-like odor. Beta-myrcene is also referred to as "myrcene”.
  • gamma-muurolene refers to a compound with the following structural formula:
  • Gamma-muurolene is often characterized as having an herbal, woody, and spicy aroma.
  • nepetalactone refers to a compound with the following structural formula:
  • Nepetalactone is often characterized as having a valerian odor. Nepetalactone is also one of the main attractants and stimulants in catnip, which, when inhaled, insights wild play behavior in many cats.
  • nerol refers to a compound with the following structural formula:
  • Nerol is often characterized a constituent of fragrances in cosmetics and as a flavor agent.
  • nerolidol refers to a compound with either of the following structural formulas or an mixture thereby:
  • Neolidol is often characterized as having a woody aroma, similar to fresh bark.
  • the term “Nerolidol” refers to either or both of the cis and trans isomers.
  • neryl acetate refers to a compound with the following structural formula:
  • Neryl acetate is often characterized as having a floral and fruity aroma.
  • nonanaldehyde refers to a compound with the following structural formula:
  • Nonanaldehyde is often characterized as having a soapy, citrus odor.
  • Nonanaldehyde is a component of perfumes, although it also occurs in several natural oils.
  • Nonanaldehyde is also referred to as nonanal.
  • nonanoic acid refers to a carboxylic acid with the following structural formula:
  • Nonanoic acid is often characterized as having an unpleasant, rancid, waxy, dirty, and cheesy aroma.
  • ocimene refers to any of the isomers in a single pure form or a mixture in any ratio.
  • octanal refers to a compound with the following structural formula:
  • Octanal is often characterized as having a very strong waxy, citrus, orange peel aroma.
  • octanoic acid refers to a compound with the following structural formula:
  • Octanoic acid is often characterized as having a musty, rancid, cheesy, sweat-like odor
  • Octanoic acid is used as a cosmetic surfactant and as a flavoring agent for processed cheeses.
  • Octanoic acid is also referred to as caprylic acid.
  • p-cymene refers to a compound with the following structural formula:
  • Cymene may refer to p-Cymene or any other isomeric form, e.g., m-Cymene or o-Cymene.
  • Pentyl butyrate is often characterized as having a smell reminiscent of pear or apricot.
  • Alpha-phellandrene is often characterized as having a citrus, herbal, black pepper-like odor.
  • Beta- phellandrene is often characterized as having a peppery -minty and slightly citrusy odor with a slight minty-turpentine note.
  • phenylacetaldehyde refers to a compound with the following structural formula:
  • Phenylacetaldehyde is often characterized as having a strong pungent honey-like sweet and green floral odor. Phenylacetaldehyde is found in buckwheat, chocolate, and many other foods and flowers.
  • phenylethanethiol refers to a compound with the following chemical formula: CsHioS comprising of multiple isomers.
  • phenylethanethiol refers to any of the isomers as a pure compound and/or in any mixture. Phenylethanethiol is often characterized as having the high strength odor of rubber.
  • phenylacetic acid refers to a compound with the following structural formula:
  • Phenylacetic acid is often characterized as having a sour yet sweet, waxy, civet, honey, rosey, floral odor similar to honeysuckle with notes of chocolate and tobacco. Phenylacetic acid is also used in cosmetics for perfuming.
  • Phytol is often characterized having a mild floral, balsamic, and green tea type of aroma.
  • alpha-pinene refers to a compound with either of the following structural formulas:
  • Alpha-Pinene is often characterized as having a pine tree like aroma.
  • beta-pinene refers to a terpene with the following structural formula:
  • Beta-Pinene is often characterized as having a woody -green pine-like smell. Beta-Pinene is one of the most abundant compounds released by forest trees. Beta-Pinene is an isomer of pinene.
  • pristimerin refers to a compound with the following structural formula:
  • Pristimerin is often characterized as having antiviral and antitumor properties. Pristimerin is also called celastrol methyl ester celastrol.
  • pulsegone refers to a compound with the following structural formula:
  • Pulegone is often characterized as having a smell similar to peppermint.
  • quercetin refers to a compound with the following structural formula:
  • retinol refers to a compound with the following structural formula:
  • Retinol is often characterized as a type of vitamin A that can be converted to other types of vitamin A.
  • rutin refers to a compound with the following structural formula:
  • Rutin is often characterized as citrus flavonoid and found in many plants.
  • sabinene refers to a compound with the following structural formula:
  • Sabinene is often characterized as having a peppery, woody, herbaceous, and spicy pine odor with citrus notes. Sabinene is found in oak trees, tea tree oil, black pepper and is a major constituent of carrot seed oil.
  • sabinene refers to either a enantiomeric form or a mixture in any ratio.
  • sabinene hydrate refers to a compound with the following structural formula:
  • Sabinene hydrate is often characterized as having an herbal, minty, eucalyptol, and terpy odor with a spicy nuance.
  • cis-sabinene hydrate refers to a compound with the following structural formula.
  • Cis-sabinene hydrate is often characterized as having a balsamic odor.
  • trans-sabinene hydrate refers to the following structural formula.
  • Trans-sabinene hydrate is often characterized as having a woody, balsamic odor.
  • safranal refers to a compound the following structural formula:
  • Safranal is often characterized as the component primarily responsible for the aroma of saffron.
  • alpha-selinene refers to a compound with the following structural formula:
  • Alpha-selinene is often characterized as having a distinct odor of amber. Alpha-selinene is one of the principal components of the oil from celery seeds.
  • alpha-sinensal refers to a compound with the following structural formula:
  • Alpha-sinensal is often characterized as having a citrus orange, mandarin aroma.
  • beta-sinensal refers to a compound with the following structural formula:
  • Beta-sinensal is often characterized as having a sweet, fresh, waxy, and citrus odor. Beta-sinensal is used in fragrances.
  • beta-sitosterol refers to a compound with the following structural formula:
  • Beta-sitosterol is found in pecans, avocados, pumpkin seeds, cashews, corn oils, and soybeans.
  • Squalene is often characterized as playing an important part in the synthesis of plant and animal sterols.
  • taxadiene refers to a compound with the following structural formula:
  • Taxadiene is an intermediate in the synthesis of taxol.
  • terpin refers to a compound of the following structural formula:
  • terpineol refers to a compound with the following structural formula:
  • terpineol includes any of the isomeric forms either as a single form or a mixture in any ratio. Terpineol is used extensively in the perfume industry. Within the context of this disclosure, terpineol refers to any and all isomeric forms, alpha, beta, gamma, etc, in any ratio or combination,
  • terpinen-4-ol refers to the isomer of terpineol that has the following structural formula:
  • Terpinen-4-ol is often characterized as having an herbaceous, peppery, woody odor and is used in commercial fragrances. Terpinen-4-ol is considered the primary active ingredient of tea tree oil.
  • alpha-terpinene refers a compound the following structural formula:
  • Alpha-terpinene is often characterized as having a lemony-citrus aroma. Alpha-terpinene has been isolated from cardamom and marjoram oils.
  • gamma-terpinene refers to a compound with the following structural formula:
  • Gamma-terpinene is often characterized as having an herbaceous, citrusy sweet aroma.
  • terpinolene or “delta-terpinene” refers to a compound with the following structural formula:
  • Terpinolene is often characterized as having an herbal aroma. Terpinolene' s flavor has been described as sweet, woody, lemon, and lime-like.
  • thiophenol refers to a compound with the following structural formula:
  • Thiophenol is often characterized as having a sulfurous odor.
  • thujone refers to a compound with either of the following structural formulas:
  • thujone refers to any of the isomeric forms in a pure form or mixture of any ratio. Thujone is often characterized as having a menthol like odor.
  • thymol refers to a compound with the following structural formula:
  • Thymol is often found in oil of thyme.
  • alpha-tocopherol refers to a compound with the following structural formula:
  • Alpha-tocopherol is often characterized as having a very bland, slight, vegetable oil-like odor.
  • nonka undecanone refers to a compound with the following structural formula:
  • Tonka undecanone is often characterized as having a sweet, spicy, balsamic, and Tonka woody tobacco aroma.
  • Undecanal is often characterized as having a soapy, aldehydic, waxy, and slightly effervescent orangey citrus-like odor with a watermelon, pineapple and cilantro background. Undecanal is a common component of perfumes.
  • valeraldehyde or "pentanal” refers to a compound with the following structural formula:
  • Valeraldehyde is often characterized as having a fermented type, diffusive, bready, fruity odor with berry nuances. Used as a flavoring agent, valeraldehyde has a wine-like, fermented, bready, cocoa flavor with chocolate notes.
  • verdoxan refers to a cyclic ether with the following structural formula:
  • Verdoxan is often characterized as having a medium strength odor of earthy, fruity, green, herbal, sawn old wood. Verdoxan is used in fragrances and cosmetics.
  • alpha-y GmbH refers to a compound with the following structural formula:
  • Alpha-ymaschinee is often characterized as having a spicy, fruity aroma.
  • Alpha-ymaschinee is a natural substance often found in wine and is emitted by some plants.
  • vanillin refers to a compound with the following structural formula:
  • Vanillin is often characterized as having a pleasant, sweet aroma, and the characteristic vanilla-like flavor.
  • compositions comprising unique combinations of a first purified cannabinoid and a first purified terpene.
  • the first purified cannabinoid and first purified terpene are present in non-naturally occurring concentrations.
  • the first purified cannabinoid and first purified terpene are present in non-naturally occurring ratios.
  • the compositions disclosed herein provide particular benefits previously unavailable with naturally occurring cannabinoid and/or terpene profiles, such as those found in plants, harvested flowers, extracts, or conventional products derived from the same.
  • the said combination of a first purified cannabinoid and a first purified terpene provide a synergistic effect at a mammalian cellular receptor, such as a G protein coupled receptor.
  • the receptor is CB1.
  • the receptor is CB2.
  • the receptor is GPR55.
  • the receptor is 5HT-1A.
  • the receptor is 5HT-2A.
  • the receptor is TRPV1.
  • the receptor is an opioid receptor, e.g., ⁇ -opioid receptor.
  • composition comprising:
  • a first purified cannabinoid chosen from THC, D9-THC, D8-THC, THCA, THCV, D8-THCV, D9-THCV, THCVA, CBD, CBDA, CBDV, CBDVA, CBC, CBCA, CBCV, CBCVA, CBG, CBGA, CBGV, CBGVA, CBN, CBNA, CBNV, CBNVA, CBND, CBNDA, CBNDV, CBNDVA, CBE, CBEA, CBEV, CBEVA, CBL, CBLA, CBLV, or CBLVA; and
  • a first purified terpene chosen from Limonene, Nerolidol, Beta-Myrcene, Linalool, Alpha-Caryophyllene, Beta-Caryophyllene, Alpha-Pinene, Beta-Pinene, Alpha-Bisabolol, Delta-3-Carene, Borneol, p-Cymene, Eucalyptol, Alpha-Humulene, Alpha-Terpineol, Terpinolene, Pulegone, Camphene, or Geraniol.
  • using "combination of a first purified cannabinoid and a first purified terpene” may be accomplished by a formulating a homogeneous mixture prior to consuming (e.g., combusting, vaporizing, inhaling, or ingesting) the mixture.
  • compositions disclosed herein are combined with a carrier oil.
  • carrier oil refers to a substance facilitating the administration of the compositions disclosed herein.
  • the carrier oil is grapeseed oil.
  • the carrier oil is coconut oil.
  • the carrier oil is polyethylene glycol.
  • polyethylene glycol refers to a compound with the following structural formula:
  • n is an integer.
  • Polyethylene glycol is also known as PEG, polyethylene oxide (PEO), and polyoxyethylene
  • the purified components disclosed herein are purposefully chosen for a desired effect.
  • the purposefully chosen purified components are then combined with a carrier oil.
  • the purposefully purified components in the carrier oil is combined with a food product.
  • the purposefully purified components in the carrier oil is combined with a beverage product.
  • the purposefully purified components in the carrier oil is combined with a personal care product, e.g., topical cream, soap, shampoo, etc.
  • the purposefully purified components in the carrier oil is combined with a drug.
  • the purposefully purified components in the carrier oil is combined with a plant extract.
  • the purposefully purified components in the carrier oil is used with a device, e.g., vaporizer, intravenous drug, etc.
  • the purposefully purified components in the carrier oil is used in combination with any of the above-mentioned embodiments.
  • particular purified components such as purified terpenes, may be added to purified or unpurified cannabinoids to create the compositions disclosed herein at the time of use.
  • use includes consuming via ingestion or heating and inhaling by, for example, combusting or vaporizing.
  • purified components such as purified terpenes
  • purified or unpurified cannabinoids may be added to purified or unpurified cannabinoids to create the compositions disclosed herein at the time of use.
  • use includes consuming via ingestion or heating and inhaling by, for example, combusting or vaporizing.
  • the first purified cannabinoid is THC and the first purified terpene is Limonene.
  • the first purified cannabinoid is THC and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is THC and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is THC and the first purified terpene is Linalool.
  • the first purified cannabinoid is THC and the first purified terpene is Alpha-C aryophy llene . In one embodiment, the first purified cannabinoid is THC and the first purified terpene is Beta-C aryophy llene .
  • the first purified cannabinoid is THC and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is THC and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is THC and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is THC and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is THC and the first purified terpene is Borneol.
  • the first purified cannabinoid is THC and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is THC and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is THC and the first purified terpene is Alpha-Terpineol.
  • the first purified cannabinoid is THC and the first purified terpene is Alpha-Humulene .
  • the first purified cannabinoid is THC and the first purified terpene is Terpinolene.
  • the first purified cannabinoid is THC and the first purified terpene is Pulegone.
  • the first purified cannabinoid is THC and the first purified terpene is Camphene.
  • the first purified cannabinoid is THC and the first purified terpene is Geraniol.
  • the first purified cannabinoid is D9-THC and the first purified terpene is Limonene.
  • the first purified cannabinoid is D9-THC and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is D9-THC and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is D9-THC and the first purified terpene is Linalool. In one embodiment, the first purified cannabinoid is D9-THC and the first purified terpene -Caryophyllene.
  • the first purified cannabinoid is D9-THC and the first purified terpeneCaryophyllene.
  • the first purified cannabinoid is D9-THC and the first purified terpene -Pinene.
  • the first purified cannabinoid is D9-THC and the first purified terpenePinene.
  • the first purified cannabinoid is D9-THC and the first purified terpene -Bisabolol.
  • the first purified cannabinoid is D9-THC and the first purified terpene-3-Carene.
  • the first purified cannabinoid is D9-THC and the first purified terpeneol.
  • the first purified cannabinoid is D9-THC and the first purified terpeneyptol.
  • the first purified cannabinoid is D9-THC and the first purified terpene ene.
  • the first purified cannabinoid is D9-THC and the first purified terpene - Terpineol.
  • the first purified cannabinoid is D9-THC and the first purified terpene -Humulene.
  • the first purified cannabinoid is D9-THC and the first purified terpenenolene.
  • the first purified cannabinoid is D9-THC and the first purified terpeneone.
  • the first purified cannabinoid is D9-THC and the first purified terpenehene.
  • the first purified cannabinoid is D9-THC and the first purified terpeneiol.
  • the first purified cannabinoid is D8-THC and the first purified terpenenene.
  • the first purified cannabinoid is D8-THC and the first purified terpeneidol.
  • the first purified cannabinoid is D8-THC and the first purified terpeneMyrcene. In one embodiment, the first purified cannabinoid is D8-THC and the first purified terpene is Linalool.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Alpha-Caryophyllene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Beta-Caryophyllene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Borneol.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is D8-THC and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Alpha- Terpineol.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Alpha-Humulene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Terpinolene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Pulegone.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Camphene.
  • the first purified cannabinoid is D8-THC and the first purified terpene is Geraniol.
  • the first purified cannabinoid is THCA and the first purified terpene is Limonene.
  • the first purified cannabinoid is THCA and the first purified terpene is Nerolidol. In one embodiment, the first purified cannabinoid is THCA and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is THCA and the first purified terpene is Linalool.
  • the first purified cannabinoid is THCA and the first purified terpene is Alpha-Caryophyllene.
  • the first purified cannabinoid is THCA and the first purified terpene is Beta-C aryophy llene .
  • the first purified cannabinoid is THCA and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is THCA and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is THCA and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is THCA and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is THCA and the first purified terpene is Borneol.
  • the first purified cannabinoid is THCA and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is THCA and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is THCA and the first purified terpene is Alpha-Terpineol.
  • the first purified cannabinoid is THCA and the first purified terpene is Alpha-Humulene .
  • the first purified cannabinoid is THCA and the first purified terpene is Terpinolene.
  • the first purified cannabinoid is THCA and the first purified terpene is Pulegone.
  • the first purified cannabinoid is THCA and the first purified terpene is Camphene.
  • the first purified cannabinoid is THCA and the first purified terpene is Geraniol.
  • the first purified cannabinoid is THCV and the first purified terpene is Limonene. In one embodiment, the first purified cannabinoid is THCV and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is THCV and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is THCV and the first purified terpene is Linalool.
  • the first purified cannabinoid is THCV and the first purified terpene is Alpha-Caryophyllene.
  • the first purified cannabinoid is THCV and the first purified terpene is Beta-C aryophy llene .
  • the first purified cannabinoid is THCV and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is THCV and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is THCV and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is THCV and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is THCV and the first purified terpene is Borneol.
  • the first purified cannabinoid is THCV and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is THCV and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is THCV and the first purified terpene is Alpha-Terpineol.
  • the first purified cannabinoid is THCV and the first purified terpene is Alpha-Humulene .
  • the first purified cannabinoid is THCV and the first purified terpene is Terpinolene.
  • the first purified cannabinoid is THCV and the first purified terpene is Pulegone.
  • the first purified cannabinoid is THCV and the first purified terpene is Camphene.
  • the first purified cannabinoid is THCV and the first purified terpene is Geraniol. In one embodiment, the first purified cannabinoid is THCVA and the first purified terpenenene.
  • the first purified cannabinoid is THCVA and the first purified terpeneidol.
  • the first purified cannabinoid is THCVA and the first purified terpeneMyrcene.
  • the first purified cannabinoid is THCVA and the first purified terpene ol.
  • the first purified cannabinoid is THCVA and the first purified terpene -Caryophyllene.
  • the first purified cannabinoid is THCVA and the first purified terpeneCaryophyllene.
  • the first purified cannabinoid is THCVA and the first purified terpene -Pinene.
  • the first purified cannabinoid is THCVA and the first purified terpenePinene.
  • the first purified cannabinoid is THCVA and the first purified terpene -Bisabolol.
  • the first purified cannabinoid is THCVA and the first purified terpene-3-Carene.
  • the first purified cannabinoid is THCVA and the first purified terpeneol.
  • the first purified cannabinoid is THCVA and the first purified terpeneyptol.
  • the first purified cannabinoid is THCVA and the first purified terpene ene.
  • the first purified cannabinoid is THCVA and the first purified terpene - Terpineol.
  • the first purified cannabinoid is THCVA and the first purified terpene -Humulene.
  • the first purified cannabinoid is THCVA and the first purified terpenenolene.
  • the first purified cannabinoid is THCVA and the first purified terpeneone.
  • the first purified cannabinoid is THCVA and the first purified terpenehene. In one embodiment, the first purified cannabinoid is THCVA and the first purified terpene is Geraniol.
  • the first purified cannabinoid is CBD and the first purified terpene is Limonene.
  • the first purified cannabinoid is CBD and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is CBD and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is CBD and the first purified terpene is Linalool.
  • the first purified cannabinoid is CBD and the first purified terpene is Alpha-Caryophyllene.
  • the first purified cannabinoid is CBD and the first purified terpene is Beta-C aryophy llene .
  • the first purified cannabinoid is CBD and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is CBD and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is CBD and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is CBD and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is CBD and the first purified terpene is Borneol.
  • the first purified cannabinoid is CBD and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is CBD and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is CBD and the first purified terpene is Alpha-Terpineol.
  • the first purified cannabinoid is CBD and the first purified terpene is Alpha-Humulene .
  • the first purified cannabinoid is CBD and the first purified terpene is Terpinolene.
  • the first purified cannabinoid is CBD and the first purified terpene is Pulegone. In one embodiment, the first purified cannabinoid is CBD and the first purified terpene is Camphene.
  • the first purified cannabinoid is CBD and the first purified terpene is Geraniol.
  • the first purified cannabinoid is CBDA and the first purified terpene is Limonene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is CBDA and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Linalool.
  • the first purified cannabinoid is CBDA and the first purified terpene is Alpha-Caryophyllene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Beta-C aryophy llene .
  • the first purified cannabinoid is CBDA and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is CBDA and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Borneol.
  • the first purified cannabinoid is CBDA and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is CBDA and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Alpha-Terpineol.
  • the first purified cannabinoid is CBDA and the first purified terpene is Alpha-Humulene .
  • the first purified cannabinoid is CBDA and the first purified terpene is Terpinolene. In one embodiment, the first purified cannabinoid is CBDA and the first purified terpene is Pulegone.
  • the first purified cannabinoid is CBDA and the first purified terpene is Camphene.
  • the first purified cannabinoid is CBDA and the first purified terpene is Geraniol.
  • the first purified cannabinoid is CBDV and the first purified terpene is Limonene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is CBDV and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Linalool.
  • the first purified cannabinoid is CBDV and the first purified terpene is Alpha-Caryophyllene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Beta-C aryophy llene .
  • the first purified cannabinoid is CBDV and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is CBDV and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Borneol.
  • the first purified cannabinoid is CBDV and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is CBDV and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Alpha-Terpineol.
  • the first purified cannabinoid is CBDV and the first purified terpene is Alpha-Humulene . In one embodiment, the first purified cannabinoid is CBDV and the first purified terpene is Terpinolene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Pulegone.
  • the first purified cannabinoid is CBDV and the first purified terpene is Camphene.
  • the first purified cannabinoid is CBDV and the first purified terpene is Geraniol.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Limonene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Linalool.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Alpha-Caryophyllene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Beta-Caryophyllene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Alpha-Pinene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Beta-Pinene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Alpha-Bisabolol.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Delta-3-Carene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Borneol.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Eucalyptol.
  • the first purified cannabinoid is CBDVA and the first purified terpene is p-Cymene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Alpha- Terpineol. In one embodiment, the first purified cannabinoid is CBDVA and the first purified terpene is Alpha-Humulene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Terpinolene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Pulegone.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Camphene.
  • the first purified cannabinoid is CBDVA and the first purified terpene is Geraniol.
  • the first purified cannabinoid is CBC and the first purified terpene is Limonene.
  • the first purified cannabinoid is CBC and the first purified terpene is Nerolidol.
  • the first purified cannabinoid is CBC and the first purified terpene is Beta-Myrcene.
  • the first purified cannabinoid is CBC and the first purified terpene is Linalool.
  • the first purified cannabinoid is CBC and the first purified terpene is Alpha-Caryophyllene.

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pyrane Compounds (AREA)

Abstract

L'invention concerne de nouvelles compositions comportant un cannabinoïde purifié et un terpène purifié. Dans un mode de réalisation, les compositions comportent un ou plusieurs cannabinoïdes purifiés. Dans un mode de réalisation, les compositions comportent un ou plusieurs cannabinoïdes purifiés en combinaison avec un ou plusieurs terpènes purifiés. Dans un mode de réalisation, les compositions comportent des rapports ne se produisant pas naturellement. Dans un mode de réalisation, les compositions comportent des concentrations ne se produisant pas naturellement. Dans un mode de réalisation, les compositions comportent des effets inattendus et/ou synergiques.
EP18760302.2A 2017-03-01 2018-03-01 Compositions sélectionnées de manière ciblée comportant des cannabinoïdes purifiés et/ou des terpènes purifiés Withdrawn EP3589129A4 (fr)

Applications Claiming Priority (18)

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US201762465688P 2017-03-01 2017-03-01
US201762469415P 2017-03-09 2017-03-09
US201762475153P 2017-03-22 2017-03-22
US201762477990P 2017-03-28 2017-03-28
US201762489360P 2017-04-24 2017-04-24
US201762490567P 2017-04-26 2017-04-26
US201762490465P 2017-04-26 2017-04-26
US201762491160P 2017-04-27 2017-04-27
US201762491175P 2017-04-27 2017-04-27
US201762491899P 2017-04-28 2017-04-28
US201762491980P 2017-04-28 2017-04-28
US201762509651P 2017-05-22 2017-05-22
US201762510229P 2017-05-23 2017-05-23
US201762510660P 2017-05-24 2017-05-24
US201762510672P 2017-05-24 2017-05-24
US201762511218P 2017-05-25 2017-05-25
US15/616,874 US20170266153A1 (en) 2015-02-27 2017-06-07 Compositions purposefully selected comprising purified cannabinoids and/or purified terpenes
PCT/US2018/020440 WO2018160827A1 (fr) 2017-03-01 2018-03-01 Compositions sélectionnées de manière ciblée comportant des cannabinoïdes purifiés et/ou des terpènes purifiés

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WO2019147690A1 (fr) 2018-01-23 2019-08-01 High Sierra Technologies, Inc. Produits à base de cannabis modifiés par élimination de composés organiques volatils et ajout d'hydrocarbures insaturés volatils
IL266151A (en) * 2019-04-18 2019-07-31 Kanabo Res Ltd Dilute for the cannabinoid preparations
WO2021012044A1 (fr) 2019-07-22 2021-01-28 Canopy Growth Corporation Cristallisation continue de cannabinoïdes dans un réacteur à cuve agitée
KR20220106158A (ko) * 2019-11-26 2022-07-28 라이코드 리미티드 칸나비노이드 및 라이코펜 항염증 상승작용적 조합물
CN115605289A (zh) * 2020-04-29 2023-01-13 利加尔有限合伙公司（Nz） 印迹聚合物及其使用方法
WO2022020944A1 (fr) * 2020-07-27 2022-02-03 Canopy Growth Corporation Procédés de synthèse de cannabielsoin et d'analogues de ceux-ci
WO2022165165A1 (fr) * 2021-01-29 2022-08-04 The Johns Hopkins University Effets de limonène sur l'anxiété induite par tétrahydrocannabinol (thc)
CN113368086B (zh) * 2021-08-11 2021-12-03 龙麻(上海)医药研发有限责任公司 一种大麻素组合物及其在制备治疗帕金森、阿尔茨海默等神经退行性疾病的药物中的应用
WO2023245185A1 (fr) * 2022-06-17 2023-12-21 New Growth Brands, Inc. Compositions comprenant des cannabinoïdes et leurs procédés de préparation et d'utilisation

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AU2018227544A1 (en) 2019-08-29
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BR112019018088A2 (pt) 2020-03-24
EP3589129A4 (fr) 2020-11-25
CA3054690A1 (fr) 2018-09-07
CN110582206A (zh) 2019-12-17
MX2019010370A (es) 2019-10-22
IL268929A (en) 2019-10-31

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