EP3585354A1 - Oral care compositions and methods of use - Google Patents
Oral care compositions and methods of useInfo
- Publication number
- EP3585354A1 EP3585354A1 EP18708827.3A EP18708827A EP3585354A1 EP 3585354 A1 EP3585354 A1 EP 3585354A1 EP 18708827 A EP18708827 A EP 18708827A EP 3585354 A1 EP3585354 A1 EP 3585354A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- amount
- weight
- oral care
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 177
- 238000000034 method Methods 0.000 title claims abstract description 12
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims abstract description 69
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims abstract description 42
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 40
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims abstract description 36
- 235000019445 benzyl alcohol Nutrition 0.000 claims abstract description 23
- 239000003755 preservative agent Substances 0.000 claims abstract description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 29
- 239000000551 dentifrice Substances 0.000 claims description 18
- 210000000214 mouth Anatomy 0.000 claims description 16
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 12
- 230000036541 health Effects 0.000 claims description 11
- 239000000796 flavoring agent Substances 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 9
- 239000003906 humectant Substances 0.000 claims description 8
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 235000006708 antioxidants Nutrition 0.000 claims description 7
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 230000000813 microbial effect Effects 0.000 claims description 5
- 210000003298 dental enamel Anatomy 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 206010020751 Hypersensitivity Diseases 0.000 claims description 3
- 206010061218 Inflammation Diseases 0.000 claims description 3
- 208000026935 allergic disease Diseases 0.000 claims description 3
- 230000032770 biofilm formation Effects 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 230000036996 cardiovascular health Effects 0.000 claims description 3
- 230000001013 cariogenic effect Effects 0.000 claims description 3
- 238000005115 demineralization Methods 0.000 claims description 3
- 230000002328 demineralizing effect Effects 0.000 claims description 3
- 208000002925 dental caries Diseases 0.000 claims description 3
- 206010013781 dry mouth Diseases 0.000 claims description 3
- 230000003628 erosive effect Effects 0.000 claims description 3
- 208000007565 gingivitis Diseases 0.000 claims description 3
- 230000035876 healing Effects 0.000 claims description 3
- 230000009610 hypersensitivity Effects 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 230000003902 lesion Effects 0.000 claims description 3
- 230000007406 plaque accumulation Effects 0.000 claims description 3
- 230000008439 repair process Effects 0.000 claims description 3
- 230000009885 systemic effect Effects 0.000 claims description 3
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 abstract description 27
- 238000009472 formulation Methods 0.000 abstract description 8
- 230000002335 preservative effect Effects 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 description 25
- -1 dental strips Substances 0.000 description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 23
- 239000004615 ingredient Substances 0.000 description 15
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 12
- 239000002245 particle Substances 0.000 description 12
- 150000002978 peroxides Chemical class 0.000 description 12
- 239000002562 thickening agent Substances 0.000 description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 239000000377 silicon dioxide Substances 0.000 description 9
- 239000007844 bleaching agent Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 239000000606 toothpaste Substances 0.000 description 7
- 229940034610 toothpaste Drugs 0.000 description 7
- 230000002087 whitening effect Effects 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 6
- 230000002272 anti-calculus Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 6
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 229940091249 fluoride supplement Drugs 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000003082 abrasive agent Substances 0.000 description 4
- 239000006172 buffering agent Substances 0.000 description 4
- 229920001525 carrageenan Polymers 0.000 description 4
- 230000009977 dual effect Effects 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 235000013355 food flavoring agent Nutrition 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- 208000006558 Dental Calculus Diseases 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 150000001342 alkaline earth metals Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 239000007859 condensation product Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 3
- 235000019820 disodium diphosphate Nutrition 0.000 description 3
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 235000019832 sodium triphosphate Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000206575 Chondrus crispus Species 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 244000024873 Mentha crispa Species 0.000 description 2
- 235000014749 Mentha crispa Nutrition 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- 229920002260 Pluraflo® Polymers 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000002535 acidifier Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000002610 basifying agent Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000001465 calcium Nutrition 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical class OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 235000011180 diphosphates Nutrition 0.000 description 2
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 2
- WWOYCMCZTZTIGU-UHFFFAOYSA-L magnesium;2-carboxybenzenecarboperoxoate;hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].OOC(=O)C1=CC=CC=C1C([O-])=O.OOC(=O)C1=CC=CC=C1C([O-])=O WWOYCMCZTZTIGU-UHFFFAOYSA-L 0.000 description 2
- 239000002324 mouth wash Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 150000004965 peroxy acids Chemical class 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
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- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- JLPAMKUIIFHLBH-UHFFFAOYSA-N 1,2-dihydroxypropane-1-sulfonic acid Chemical compound CC(O)C(O)S(O)(=O)=O JLPAMKUIIFHLBH-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
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- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical class CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
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- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
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- 239000000253 Denture Cleanser Substances 0.000 description 1
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 1
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
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- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 description 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 1
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical class CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
- 244000227633 Ocotea pretiosa Species 0.000 description 1
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- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
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- 229920002582 Polyethylene Glycol 600 Polymers 0.000 description 1
- 229920002593 Polyethylene Glycol 800 Polymers 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 240000001058 Sterculia urens Species 0.000 description 1
- 235000015125 Sterculia urens Nutrition 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- WOHVONCNVLIHKY-UHFFFAOYSA-L [Ba+2].[O-]Cl=O.[O-]Cl=O Chemical compound [Ba+2].[O-]Cl=O.[O-]Cl=O WOHVONCNVLIHKY-UHFFFAOYSA-L 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- ZJRXSAYFZMGQFP-UHFFFAOYSA-N barium peroxide Chemical compound [Ba+2].[O-][O-] ZJRXSAYFZMGQFP-UHFFFAOYSA-N 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 1
- 235000019402 calcium peroxide Nutrition 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- QXIKMJLSPJFYOI-UHFFFAOYSA-L calcium;dichlorite Chemical compound [Ca+2].[O-]Cl=O.[O-]Cl=O QXIKMJLSPJFYOI-UHFFFAOYSA-L 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000012933 diacyl peroxide Substances 0.000 description 1
- SHFGJEQAOUMGJM-UHFFFAOYSA-N dialuminum dipotassium disodium dioxosilane iron(3+) oxocalcium oxomagnesium oxygen(2-) Chemical compound [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Na+].[Na+].[Al+3].[Al+3].[K+].[K+].[Fe+3].[Fe+3].O=[Mg].O=[Ca].O=[Si]=O SHFGJEQAOUMGJM-UHFFFAOYSA-N 0.000 description 1
- KEKMGBDDLPULAW-UHFFFAOYSA-J dicalcium phosphono phosphate sulfate Chemical compound S(=O)(=O)([O-])[O-].[Ca+2].[O-]P([O-])(=O)OP(=O)(O)O.[Ca+2] KEKMGBDDLPULAW-UHFFFAOYSA-J 0.000 description 1
- IPGANOYOHAODGA-UHFFFAOYSA-N dilithium;dimagnesium;dioxido(oxo)silane Chemical compound [Li+].[Li+].[Mg+2].[Mg+2].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O IPGANOYOHAODGA-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000019262 disodium citrate Nutrition 0.000 description 1
- 239000002526 disodium citrate Substances 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 150000002193 fatty amides Chemical class 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 229940104869 fluorosilicate Drugs 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 229940005740 hexametaphosphate Drugs 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000002432 hydroperoxides Chemical class 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 1
- 229940048848 lauryl glucoside Drugs 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- HPGPEWYJWRWDTP-UHFFFAOYSA-N lithium peroxide Chemical compound [Li+].[Li+].[O-][O-] HPGPEWYJWRWDTP-UHFFFAOYSA-N 0.000 description 1
- KAGBQTDQNWOCND-UHFFFAOYSA-M lithium;chlorite Chemical compound [Li+].[O-]Cl=O KAGBQTDQNWOCND-UHFFFAOYSA-M 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229960004995 magnesium peroxide Drugs 0.000 description 1
- NWAPVVCSZCCZCU-UHFFFAOYSA-L magnesium;dichlorite Chemical compound [Mg+2].[O-]Cl=O.[O-]Cl=O NWAPVVCSZCCZCU-UHFFFAOYSA-L 0.000 description 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- 229960003987 melatonin Drugs 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229940074371 monofluorophosphate Drugs 0.000 description 1
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 1
- 235000018342 monosodium citrate Nutrition 0.000 description 1
- 239000002524 monosodium citrate Substances 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229940041672 oral gel Drugs 0.000 description 1
- 150000004967 organic peroxy acids Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000010451 perlite Substances 0.000 description 1
- 235000019362 perlite Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229940045916 polymetaphosphate Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 229940045872 sodium percarbonate Drugs 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940045919 sodium polymetaphosphate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- DOJOZCIMYABYPO-UHFFFAOYSA-M sodium;3,4-dihydroxy-4-oxobutanoate Chemical compound [Na+].OC(=O)C(O)CC([O-])=O DOJOZCIMYABYPO-UHFFFAOYSA-M 0.000 description 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical class [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940080728 steareth-30 Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- This invention relates to improved oral care formulations comprising precipitated calcium carbonate (PCC) and preservatives selected from the group consisting of i) phenethyl alcohol and caprylyl glycol, and ii) benzyl alcohol and caprylyl glycol as well as to methods of using and of making these compositions.
- PCC precipitated calcium carbonate
- Precipitated calcium carbonate is manufactured on a commercial scale for use in a variety of industrial, cosmetic and pharmaceutical products. Slurries of precipitated calcium carbonate, such as used in oral care compositions, are susceptible to microorganism contamination. To reduce the amount of viable microorganisms, a preservative, such as aldehyde, can be added to the slurry.
- a preservative such as aldehyde
- U.S. Patent Application Publication No. 2009/0088483 discloses combinations of a dialdehyde (such as glutaraidehyde) and a formaldehyde-releasing agent, such as
- Glutaraidehyde for example, is unstable at alkaline pH, and is therefore ineffective as a long-term preservative for this kind of material.
- some bacterial strains metabolize formaldehyde (see, for example, Di Maiuta et ai. (2009) International Biodeteri oration & Biodegradation 63 :769-777), permitting bacterial growth even in a treated PCC slurry.
- the invention is an oral care composition
- an oral care composition comprising precipitated calcium carbonate (PCC) and a combination of preservatives selected from the group consisting of i) phenethyl alcohol and caprylyl glycol, and ii) benzyl alcohol and caprylyl glycol.
- the oral care composition is a dentifrice.
- the PCC in the oral care composition is present in an amount of 30-45% by weight of the composition. In further embodiments, PCC in the oral care composition is present in an amount of 30-45% by weight of the composition and phenethyl alcohol is present in an amount of 0.1 to 1.0% by weight of the
- PCC in the oral care composition is present in an amount of 30-45% by weight of the composition
- phenethyl alcohol is present in an amount of 0.1 to 1.0% by weight of the composition
- caprylyl glycol is present in an amount of 0.1 to 1.0% by weight of the composition.
- phenethyl alcohol is present in an amount of 0.2 to 0.3% by weight of the composition and caprylyl glycol is present in an amount of 0, 13 to 0,2% by weight of the composition.
- PCC in the oral care composition is present in an amount of 30-45% by weight of the composition and benzyl alcohol is present in an amount of 0.1 to 1.0% by weight of the composition.
- PCC in the oral care composition is present in an amount of 30-45% by weight of the composition
- benzyl alcohol is present in an amount of 0.1 to 1.0% by weight of the composition
- caprylyl glycol is present in an amount of 0.1 to 1.0% by weight of the composition.
- benzyl alcohol is present in an amount of 0.2 to 0,3% by weight of the composition and caprylyl glycol is present in an amount of 0.13 to 0.2% by weight of the composition.
- the oral care composition of any of the preceding embodiments further comprises a humectant present in an amount of 10.0 to 30.0% by weight of the composition. In certain embodiments, the oral care composition of any of the preceding embodiments further comprises a surfactant present in an amount of 1.0 to 6.0% by weight of the composition. In certain embodiments, the oral care composition of any of the preceding embodiments further comprises a flavor present in an amount of 0.5 to 2.0% by weight of the composition.
- the invention is a method to improve oral health comprising applying an effective amount of the oral care composition of any of the preceding embodiments set forth to the oral cavity of a subject in need thereof.
- improving oral health may be selected from one or more of the following; a) reduce or inhibit formation of dental caries, b) reduce, repair or inhibit early enamel lesions; c) reduce or inhibit demineralization and promote remineralization of the teeth; d) reduce hypersensitivity of the teeth; e) reduce or inhibit gingivitis; f) promote healing of sores or cuts in the mouth; g) reduce levels of acid producing bacteria; h) to increase relative levels of arginolytic bacteria; i) inhibit microbial biofilm formation in the oral cavity; j) raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge; k) reduce plaque accumulation; 1) treat, relieve or reduce dry mouth; m) whiten teeth; n) enhance systemic health, including cardiovascular health, o) reduce erosion of
- the invention is a composition obtained or obtainable by combining the ingredients as set forth in any of the preceding compositions and methods.
- ranges are used as shorthand for describing each and ever ⁇ ' value that is within the range. Any value within the range can be selected as the terminus of the range,
- composition components are by weight based on a total composition or formulation weight of 100%.
- wt % is an abbreviation for weight percent.
- molecule A 40 wt % is meant to exemplify a molecule A having 40% weight of a total composition or formulation of 100%. Further, molecule A 40 wt % will constitute 40g of molecule A in a lOOg total composition of formulation.
- oral composition means the total composition that is delivered to the oral surfaces.
- the composition is further defined as a product which, during the normal course of usage, is not for the purposes of systemic administration of particular therapeutic agents, intentionally swallowed but is rather retained in the oral cavity for a time sufficient to contact substantially all of the dental surfaces and/or oral tissues for the purposes of oral activity.
- examples of such compositions include, but are not limited to, a dentifrice, a mouthwash or a mouth rinse, a topical oral gel, a denture cleanser, dental strips, beads, varnish, toothpowder and the like.
- the term "dentifrice” means paste, powder, gel, or liquid formulations unless otherwise specified.
- the dentifrice is toothpaste.
- the dentifrice composition can be in any desired form such, as deep striped, surface striped, multi-layered, having the gel surrounding the paste, or any combination thereof.
- the oral composition may be dual phase dispensed from a separated compartment dispenser,
- the oral composition is a dentifrice.
- dentifrices may include toothpowder, a dental tablet, toothpaste (dental cream), or gel, or any other known form known to one of skill in the art.
- compositions and formulations as provided herein are described and claimed with reference to their ingredients, as is usual in the art. As would be evident to one skilled in the art, the ingredients may in some instances react with one another, so that the true composition of the final formulation may not correspond exactly to the ingredients listed. Thus, it should be understood that the invention extends to the product of the combination of the listed ingredients.
- the oral care compositions of the present invention utilize precipitated calcium carbonate as an abrasive.
- the precipitated calcium carbonate particles are present in an amount of from 30 to 45 wt % based on the weight of the composition, further optionally from 35 to 40 wt % based on the weight of the composition.
- the calcium carbonate particles are present in an amount of from 40 to 45 wt % based on the weight of the composition.
- the calcium carbonate particles are present in an amount of about 42 wt % based on the weight of the composition.
- a low concentration of certain ingredient combinations e.g., benzyl alcohol and capryiyl glycol, each at 0.1 to 1 .0 wt % in one embodiment, more preferably benzyl alcohol at 0.2 to 0,3 wt % and capryiyl glycol at 0.13 to 0,2 wt % in another embodiment; phen ethyl alcohol and capryiyl glycol, each at 0.1 to 1.0 wt % in one embodiment, more preferably, phenethyl alcohol at 0,2 to 0.3 wt % and capryiyl glycol at 0.13 to 0.2 wt % in another embodiment, can reduce microbial contamination in oral care compositions containing precipitated calcium carbonate.
- certain ingredient combinations e.g., benzyl alcohol and capryiyl glycol, each at 0.1 to 1 .0 wt % in one embodiment, more preferably benzyl alcohol at 0.2 to 0,3 wt % and capryiyl glyco
- the invention provides an oral care composition
- a combination of preservatives selected from the group of i) phenethyl alcohol and capryiyl glycol, and ii) benzyl alcohol and capryiyl glycol; and optionally an orally acceptable carrier.
- the combination of preservatives is phenethyl alcohol and capryiyl glycol.
- the combination of preservatives is benzyl alcohol and capryiyl glycol.
- the oral care composition further comprises one or more ingredient categories selected from humectants, surfactants and flavors,
- compositions comprising an orally acceptable carrier.
- an "orally acceptable carrier” refers to a material or combination of materials that are safe for use in the compositions of the present invention, commensurate with a reasonable benefit/risk ratio.
- the carrier does not substantially reduce the efficacy of the ingredients within the oral care composition, such as a peroxide complex or whitening agent. Selection of specific carrier components is dependent on the desired product form, including dentifrices, rinses, gels, and paints.
- the carrier is operable to sufficiently adhere the peroxide complex against surfaces within the oral cavity to which the composition is administered, without concomitant use of a dental tray, mouthpiece, tape, or similar appliance.
- the carrier is operable for use with a tape, tray, mouthpiece or similar appliance.
- Materials among those that are useful in carriers include adhesion agents, viscosity modifiers, diluents, surfactants, foam modulators, peroxide activators, peroxide stability agents, abrasives, pH modifying agents, humectants, mouth feel agents, sweeteners, flavorants, colorants, and combinations thereof. It is understood that while general attributes of each of the above categories of materials may differ, there may be some common attributes and any given material may serve multiple purposes within two or more of such categories of materials.
- such carrier materials are selected for compatibility with the peroxide complex and with other ingredients of the composition.
- the orally acceptable carrier may comprise polymers and/or copolymers of polyethylene glycol, of ethylene oxide propylene oxide, and of silicone. If such copolymers/polymers are used, they may be selected from the commercially available materials PLURAFLO® L4370 and PLURAFLO® LI.220 (available from BASF, Wyandotte, Mich., United States of America). In one
- such polymer and/or copolymer is an ethylene oxide, propylene oxide block co-polymer of formula (ethylene oxide)x-(propylene oxide)y wherein x is an integer of 80-150, e.g. 100-130, e.g. about 1 18, and y is an integer 30-80, e.g. about 60-70, e.g. about 66, having an average molecular weight of greater than 5000, e.g., 8000-13000 Da, e.g. about 9800.
- Block copolymers of ethylene oxide/propylene oxide are useful, but higher molecular weight, e.g., >5000 Da are preferred, e.g.
- the carrier(s) provide a dentifrice with a viscosity of about 10,000 CPS to about 700,000 CPS, preferably about 30,000 CPS to about 300,000 CPS,
- the toothpaste compositions may further comprise, in addition to the precipitated calcium carbonate particles, one or more further abrasive particulates.
- Any abrasive particulates may be used and may be selected from sodium bicarbonate, calcium phosphate (e.g., dicalcium phosphate dihydrate), calcium pyrophosphate calcium sulfate, silica, iron oxide, aluminium oxide, perlite, plastic particles, e.g., polyethylene, and combinations thereof.
- Any type of silica may be used, such as hydrated silica, precipitated silica or silica gel.
- the oral care composition further comprises, as a thickener and also as an abrasive, silica particles in an amount of from 1 to 3 wt % based on the weight of the composition.
- the toothpaste composition comprises silica that has a particle size and an amount and distribution in the toothpaste composition so that the silica has a dual function, and functions not only as a dentin tubule-occluding particulate but also as an abrasive particulate.
- a dual function particulate may be provided by a commercially available silica such as INEOS AC43 (Ineos Silicas, Warrington, United Kingdom).
- silica has a median particle size less than 8 ⁇ , for example from 3 ⁇ to 5 ⁇ .
- compositions of the present invention may further comprise an abrasive useful for example as a polishing agent.
- abrasive useful for example as a polishing agent.
- Any orally acceptable abrasive can be used, but type, fineness, (particle size) and amount of abrasive should be selected so that tooth enamel is not excessively abraded in normal use of the composition.
- Suitable abrasives include silica, for example in the form of precipitated silica or as admixed with alumina, insoluble phosphates, and mixtures thereof.
- insoluble phosphates useful as abrasives are orthophosphates, polymetaphosphates and pyrophosphates.
- Illustrative examples are dicalcium orthophosphate dihydrate, calcium pyrophosphate, calcium pyrophosphate, tri calcium phosphate, calcium polymetaphosphate and insoluble sodium polymetaphosphate.
- the abrasive particles may be initially present in the oral care composition, for example, a toothpaste, having the desired particle size, or may be initially present in the composition at a larger size, so long as the structure of the particles is such that it fractures or breaks into the desired particle size upon application of mechanical force by, e.g., a toothbrush, when brushing.
- the dentifrice contains one or more humectants.
- the present invention further provides oral care
- compositions comprising: a cross-linked polyvinylpyrrolidone complexed with hydrogen peroxide, a stabilizing amount of an additional linear and/or cross-linked
- polyvinylpyrrolidone precipitated calcium carbonate ( FCC) and preservatives selected from the group consisting of i) phenethyl alcohol and caprylyl glycol, and ii) benzyl alcohol and caprylyl glycol.
- FCC precipitated calcium carbonate
- the invention may contain whitening agents.
- Some embodiments provide nonaqueous dentifrice compositions comprising from 5 to 20 wt % cross-linked
- polyvinylpyrrolidone complexed with hydrogen peroxide PVP-H 2 0 2
- Other embodiments provide oral care compositions comprising from 5 to 12 wt % cross-linked polyvinylpyrrolidone complexed with hydrogen peroxide.
- Still other embodiments provide oral care compositions comprising from 9 to 12 wt % cross-linked
- non-aqueous dentifrice compositions comprising 1 1 wt % crosslinked
- the present invention provides non-aqueous dentifrice compositions comprising from 0,03 to about 3 wt % of an additional linear and/or crosslinked polyvinylpyrrolidone. Some embodiments provide compositions comprising 1.75 wt %, by weight, of an additional linear and/or cross-linked polyvinylpyrrolidone, [0034]
- the invention may contain additional whitening agents in addition to PYP-i N Any whitening agent known or developed in the art may be used.
- the whitening agent includes solid whitening agents and bound whitening agents which are substantially anhydrous oxygen generating compounds. Solid whitening agents useful herein include peroxides, metal chlorites, persultate.
- Exemplar)' peroxide phases include hydroperoxides, hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, pharmaceutically-acceptable salts thereof, and mixtures thereof.
- Peroxides of alkali and alkaline earth metals include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof.
- Organic peroxy compounds include urea peroxide, glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof.
- Peroxy acids and their salts include organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as and perborate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof.
- Preferred solid peroxides are sodium perborate, urea peroxide, and mixtures thereof.
- Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite.
- the whitening agent may be preferably bound.
- peroxide may be bound to a polymer such as PVP (poly(N-vinylpyrrolidone)).
- Suitable PVP complexes are disclosed, for example, in U.S. Pat. No. 5, 122,370, the contents of which are incorporated herein by reference. In some embodiments, it may be desirable to use any known whitening agent except sodium percarbonate and/or any of the
- the non-aqueous dentifrice comprises a substantially anhydrous orally acceptable carrier and various dentifrice ingredients to adjust the rheology and feel of the composition such as humectants, surface active agents, thickening or gelling agents, etc.
- Flavorants may be included if desired, in the composition.
- the oral care composition can optionally include at least one orally acceptable source of fluoride ions. Any known or to be developed in the art may be used. Suitable sources of fluoride ions include fluoride, monofluorophosphate and fluorosilicate salts. One or more fluoride ion-releasing compound is optionally present in an amount providing a total of about 100 to about 20,000 ppm, about 200 to about 5,000 ppm, or about 500 to about 2,500 ppm, fluoride ions,
- compositions of the present invention optionally comprise an antimicrobial (e.g., antibacterial) agent
- an antimicrobial agent e.g., antibacterial
- One or more antimicrobial agents are optionally present in an antimicrobial effective total amount, typically about 0,05% to about 10%, for example about 0.1 % to about 3%.
- compositions of the present invention optionally comprise an antioxidant.
- Any oral ly acceptable antioxidant can be used, including butylated hydroxyanisole
- BHA butylated hydroxvtoluene
- vitamin A carotenoids
- vitamin E flavonoids
- polyphenols ascorbic acid
- herbal antioxidants chlorophyll
- melatonin and mixtures thereof.
- compositions of the present invention optionally comprise a sialagogue or saliva-stimulating agent, an antiplaque agent, an anti -inflammatory agent, a desensitizing.
- the oral composition comprises an anticalculus (tartar control) agent.
- tartar control agents are categorized as being incompatible with some whitening agents, but embodiments of the present invention incorporate tartar control agents and whitening agents in a single phase whitening composition.
- Suitable anticalculus agents include without limitation
- phosphates and polyphosphates for example pyrophosphates
- the anticalculus agent is present at about 0.1% to about 30%.
- the oral composition may include a mixture of different anticalculus agents.
- TSPP tetrasodium pyrophosphate
- SAPP sodium acid pyrophosphate
- the anticalculus agent comprises TSPP at about 1-2% and SAPP at about 0.5 to 5%.
- tetrasodium pyrophosphate (TSPP) and/or sodium tripolyphosphate (STPP) are used.
- the anticalculus agent comprises TSPP at about 1-2% and STPP at about 7% to 10%.
- compositions of the present invention optionally compri se a thickener.
- Any orally acceptable thickening agent can be used, including without limitation carbomers, also known as carboxvvinyl polymers, carrageenans, also known as Irish moss and more particularly— carrageen an (iota-carrageenan), high molecular weight polyethylene glycols (such as CARBOWAX®, available from The Dow Chemical Company), cellulosic polymers such as hydroxyethylcellulose, carboxymethylcellulose (CMC) and salts thereof, e.g., CMC sodium, natural gums such as karaya, xanthan, gum arable and tragacanth, colloidal magnesium aluminum silicate, and colloidal and/or fumed silica and mixtures of the same.
- One or more thickening agents are optionally present in a total amount of about 0.1 % to about 90%, for example about 1% to about 50% or about 5%> to about 35%.
- Thickening agents suitable for use in the compositions of the present invention include natural and synthetic gums and colloids. Suitable thickening agents include naturally occurring polymers such as carrageenan, xanthan gum, polyglycols of varying molecular weights sold under the tradename Polyox, and polyvinylpyrrolidone.
- Compatible inorganic thickening agents include amorphous silica compounds which function as thickening agents and include colloidal silicas compounds available under the trade designation Cab-o-sil (Cabot Corporation and distributed by Lenape Chemical, Bound Brook, NJ), Zeodent 165 (J. M. Huber Chemicals Division, Havre de Grace, Md); and Sylodent 1 5 (Davison Chemical Division of W. R. Grace Corporation, Baltimore, Md).
- Other inorganic thickening agents include natural and synthetic clays such as hectorite clays, lithium magnesium silicate (laponite) and magnesium aluminum silicate (Veegum).
- the thickening agent may be selected from carrageenan (Iris moss), xanthan gum, starch, polyvinyl pyrrolidone and amorphous siiicas, or any combination thereof.
- ingredients are sometimes identified herein by category, e.g., humectant, antioxidant, thickener, etc., this identification is for convenience and clarity, but is not intended to be limiting. All of the ingredients in the compositions may have functions in addition to their primary function, and may contribute to the overall properties of the composition, including its stability, efficacy, consistency, mouth feel, taste, odor and so forth.
- the sweetener may be sodium saccharin.
- the buffering agents may be a sodium phosphate buffer
- surfactants may be included, if desired.
- suitable surfactants inciude water-soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of monosulfated monoglycende of hydrogenated coconut oil fatty acids; higher alkyl sulfates such as sodium lauryl sulfate; alkyl aryl sulfonates such as sodium dodecyl benzene sulfonate; higher alkyl sulfoacetates, such as sodium lauryl sulfoacetate; higher fatty acid esters of 1,2-dihydroxypropane sulfonate; and the substantially saturated higher aliphatic acyl amides of lower aliphatic amino carboxylic compounds, such as those having 12-16 carbons in the fatty acid, alkyl or acyl radicals; and the like.
- amides examples include N-lauryl sarcosme, and the sodium, potassium and ethanolamine salts of N-lauryl, N-myristoyl, or N-palmitoyl sarcosine.
- Others include, for example, nonanionic poly oxy ethylene surfactants, such as Polyoxamer 407, Steareth 30, Poiysorbate 20, and castor oil; and amphoteric surfactants, such as cocamidopropyl betaine (tegobaine), and cocamidopropyl betaine lauryl glucoside; condensation products of ethylene oxide with various hydrogen containing compounds that are reactive therewith and have long hydrocarbon chains (e.g., aliphatic chains of from 12 to 20 carbon atoms), which condensation products (ethoxamers) contain hydrophilic polyoxy ethylene moieties, such as condensation products of poly (ethylene oxide) with fatty acids, fatty, alcohols, fatty amides and other fatty moieties, and with propylene oxide and
- the surfactant may be sodium lauryl sulfate (SLS).
- suitable surfactants include, without limitation, water-soluble salts of ethylene-20 alkyl sulfates, sulfonated monoglycerides of C8-20 fatty acids, sarcosinates, taurates, sodium lauryl sulfate, sodium coroyi
- the oral care compositions of the invention may also include a flavoring agent.
- Flavoring agents which are used in the practice of the present invention include, but are not limited to, essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials.
- the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. Also useful are such chemicals as menthol, carvone, and anethoie.
- Certain embodiments employ the oils of peppermint and spearmint.
- the flavoring agent is incorporated in the oral composition at a concentration of 0.1 to about 5% by weight. In certain embodiments, the flavoring agent is incorporated at 0.5 to 2.0 % by weight.
- pH modifying agents among those useful herein include acidifying agents to lower pH, basifying agents to raise pH, and buffering agents to control pH within a desired range.
- acidifying agents to lower pH include acidifying agents to raise pH, basifying agents to raise pH, and buffering agents to control pH within a desired range.
- buffering agents include acidifying agents to lower pH, basifying agents to raise pH, and buffering agents to control pH within a desired range.
- one or more compounds selected from acidifying, basifying and buffering agents can be included to provide a pH of 2 to 10, or in various
- Any orally acceptable pH modifying agent can be used, including without limitation carboxyiie, phosphoric and sulfonic acids, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate salts, etc.), imidazole and mixtures thereof.
- One or more pH modifying agents are optionally present in a total amount effective to maintain the composition in an orally acceptable pH range,
- methods are provided to improve oral health by applying an effective amount of any of the oral care composition described herein to the oral cavity of a subject in need thereof.
- the methods utilize an oral care composition comprising precipitated calcium carbonate (PCC), phenethyl alcohol and caprylyl glycol.
- PCC precipitated calcium carbonate
- the PCC in the oral care composition is present in an amount of 30-45% by weight of the composition.
- PCC in the oral care composition is present in an amount of 30-45% by weight of the
- composition and phenethyl alcohol is present in an amount of 0.1 to 1.0% by weight of the composition.
- PCC in the oral care composition is present in an amount of 30-45% by weight of the composition
- phenethyl alcohol is present in an amount of 0.1 to 1.0% by weight of the composition
- caprylyl glycol is present in an amount of 0.1 to 1 .0% by weight of the composition.
- phenethyl alcohol is present in an amount of 0.2 to 0.3% by weight of the composition and caprylyl glycol is present in an amount of 0.13 to 0.2% by weight of the composition
- the methods utilize an oral care composition comprising PCC, benzyl alcohol and caprylyl glycol .
- the PCC is present in an amount of 30-45% by weight of the composition. In further embodiments, PCC in the oral care composition is present in an amount of 30-45% by weight of the composition and benzyl alcohol is present in an amount of 0, 1 to 1.0% by weight of the composition. In further embodiments, PCC in the oral care composition is present in an amount of 30- 45% by weight of the composition, benzyl alcohol is present in an amount of 0.1 to 1.0% by weight of the composition and caprylyl glycol is present in an amount of 0.1 to 1 ,0% by weight of the composition. In further embodiments, benzyl alcohol is present in an amount of 0,2 to 0.3% by weight of the composition and caprylyl glycol is present in an amount of 0.13 to 0.2% by weight of the composition.
- the improvement in oral health may be selected from one or more of the following; a. reduce or inhibit formation of dental caries; b. reduce, repair or inhibit early enamel lesions; c. reduce or inhibit demineralization and promote remineralization of the teeth, d. reduce hypersensitivity of the teeth; e. reduce or inhibit gingivitis; f. promote healing of sores or cuts in the mouth; g. reduce levels of acid producing bacteria; h. to increase relative levels of arginolytic bacteria; i. inhibit microbial biofilm formation in the oral cavity; j . raise and/or maintain plaque pH at levels of at least pH 5,5 following sugar challenge; k. reduce plaque accumulation; 1, treat, relieve or reduce dry mouth; m.
- n enhance systemic health, including cardiovascular health, o, reduce erosion of the teeth, p, immunize the teeth against cariogenic bacteria and their effects; q. clean the teeth and oral cavity; r. reduce inflammation; and s. increase anti-oxidant levels.
- the composition remains stable when stored for at least 1 week, at least 2 weeks, at least 1 month, at least 3 months, at least 6 months, or at least 1 year. In one embodiment, the composition is stored at room temperature.
- methods are provided to improve oral health of a human or animal subject comprising contacting any composition described herein with the oral surface of the human or animal subject.
- animal subject includes higher order non-human mammals such as canines, felines, and horses.
- the oral care composition is contacted with an oral surface of the mammalian subject to thereby improve oral health in a highly efficacious manner.
- the oral care composition is applied and contacted with the oral surface.
- the dentifrice, prepared in accordance with the present invention is preferably applied regularly to an oral surface, preferably on a daily basis, at least one time daily for multiple days, but alternately every second or third day.
- the oral composition is applied to the oral surfaces from 1 to 3 times daily, for at least 2 weeks up to 8 weeks, from four months to three years, or more up to lifetime.
- compositions of the invention can be packaged into containers or dispensers known in the art, via means conventional in the art.
- the compositions are packaged into tubes, metal, plastic or laminated, with either screw top or flip top caps.
- a fraction of the gel phase sample was transferred to a new stainless steel bucket. Using an overhead stirrer (EURO STAR 200, IKA) equipped with a 4-bladed propeller stirrer, mixing was performed at 750 rpm for 1 minute. Next, to the mixture was added water, PCC slurry (previously contaminated for the study purpose), surfactant, and other ingredients (benzyl alcohol/caprylyl glycol or phenethyl alcohol/caprylyl glycol) and mixed for 15 minutes to obtain the final base.
- an overhead stirrer (EURO STAR 200, IKA) equipped with a 4-bladed propeller stirrer
- Sample preparation was made by mixing 10 grams of the final base (see Example 1) with 90 mL of diluent (TAT broth (catalog # 298410, BD) supplemented with 0.3% NaCl and 4% Tween) to achieve a 1 : 10 dilution.
- Serial dilutions of 10 '1 to 10 "6 were made in neutralizing broth (TAT supplemented with 0.3% NaCl), allowed to incubate for 0, 2, 4, 6, 24 and 48 hours, and plated in 15-20 mL of melted Modified Letheen Agar (ML A). Plates were swirled to allow complete dispersion and allowed to solidify.
- Solidified plates were then inverted and incubated at 30° C for at least 48 hours.
Abstract
Description
Claims
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EP4017459A1 (en) | 2020-03-06 | 2022-06-29 | Colgate-Palmolive Company | Toothpastes containing calcium carbonate, xanthan gum and polyacrylic acid polymer |
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US4357318A (en) * | 1981-07-31 | 1982-11-02 | Richardson-Vicks Inc. | Dentifrices with improved soluble fluoride availability |
US5288480A (en) | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
US5122370A (en) | 1991-05-20 | 1992-06-16 | Isp Investments Inc. | Method for treating acne vulgaris with a composition containing a stable, high purity, substantially anhydrous complex of PVP-H2 O.sub.2 |
JP2001039824A (en) * | 1999-07-30 | 2001-02-13 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing low-irritation aloe mesophyll |
DE102005013695A1 (en) | 2005-03-21 | 2006-09-28 | Bode Chemie Gmbh & Co | Aqueous suspensions or dispersions of inorganic pigments containing a mixture of dialdehydes and Formaldehydabspaltern |
PL2421508T3 (en) * | 2009-04-24 | 2017-06-30 | Omya International Ag | Particulate material for controlled release of active ingredients |
WO2011152819A1 (en) | 2010-06-01 | 2011-12-08 | Colgate-Palmolive Company | Oral care compositions resistant to microbial growth |
EP2925411B1 (en) | 2012-12-03 | 2017-05-17 | Colgate-Palmolive Company | Oral care compositions comprising calcium carbonate and a preservative system based on benzyl alcohol or benzoic acid, and an alkylene glycol. |
CA2945213C (en) | 2014-05-15 | 2018-11-27 | The Procter & Gamble Company | Dentifrice compositions having optimized preservatives |
US10123956B2 (en) | 2014-12-23 | 2018-11-13 | Colgate-Palmolive Company | Oral care compositions |
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- 2018-02-21 CA CA3046696A patent/CA3046696A1/en active Pending
- 2018-02-21 US US16/487,224 patent/US10596082B2/en active Active
Also Published As
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WO2018156545A1 (en) | 2018-08-30 |
CA3046696A1 (en) | 2018-08-30 |
CN110290777A (en) | 2019-09-27 |
US10596082B2 (en) | 2020-03-24 |
US20200009030A1 (en) | 2020-01-09 |
EP3585354B1 (en) | 2023-10-18 |
BR112019016663A2 (en) | 2020-04-07 |
MX2019009747A (en) | 2019-10-07 |
AU2018225111A1 (en) | 2019-08-29 |
AU2018225111B2 (en) | 2020-03-12 |
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