EP3560592B1 - Centrifuge de laboratoire, récipient centrifuge pour une centrifuge de laboratoire et procédé de fonctionnement d'un récipient centrifuge - Google Patents

Centrifuge de laboratoire, récipient centrifuge pour une centrifuge de laboratoire et procédé de fonctionnement d'un récipient centrifuge Download PDF

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Publication number
EP3560592B1
EP3560592B1 EP19163817.0A EP19163817A EP3560592B1 EP 3560592 B1 EP3560592 B1 EP 3560592B1 EP 19163817 A EP19163817 A EP 19163817A EP 3560592 B1 EP3560592 B1 EP 3560592B1
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EP
European Patent Office
Prior art keywords
centrifuge
centrifuge container
container
rotor
laboratory
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Application number
EP19163817.0A
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German (de)
English (en)
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EP3560592A3 (fr
EP3560592A2 (fr
Inventor
Eckhard Tödteberg
Matthias Höche
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Sigma Laborzentrifugen GmbH
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Sigma Laborzentrifugen GmbH
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Publication of EP3560592A2 publication Critical patent/EP3560592A2/fr
Publication of EP3560592A3 publication Critical patent/EP3560592A3/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B04B5/0421—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes pivotably mounted
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B01L2300/022—Transponder chips

Definitions

  • the invention relates to a method for operating a centrifuge container. Furthermore, the invention relates to a method for operating a laboratory centrifuge.
  • Laboratory centrifuges of the type presented here are used, for example, in biotechnology, the pharmaceutical industry, medical technology and environmental analysis.
  • Such a laboratory centrifuge is used to centrifuge a product, in particular a container or vessel with a sample or substance arranged therein, or a large number of such products at speeds which can be more than 3,000 rpm, for example more than 15,000 rpm.
  • accelerations acting on the product are to be generated, which can be, for example, more than 15,000 x g (in particular more than 16,000 x g, more than 20,000 x g up to more than 60,000 x g).
  • a mixture of substances formed by the sample or the substance is to be broken down into components of different densities by centrifugation.
  • a targeted control of the pressure and/or temperature conditions can additionally take place during the centrifugation.
  • a laboratory centrifuge may be used in connection with polymerase chain reaction (PCR), hematocrit determination, cytological examinations, or the centrifugation of microtiters, blood bags, petroleum jars or blood vessels, and the like.
  • rotors in particular swing-out rotors, angle rotors or drum rotors
  • a swing-out rotor preferably being used in a laboratory centrifuge according to the invention, on which Centrifuge holders are distributed evenly over the circumference and are held pivotable about a pivot axis oriented in the circumferential direction.
  • Such swing-bucket rotors can be used, for example, for sedimentation for smaller gravitational fields of up to approximately 6,000 ⁇ g or even up to approximately 8,600 ⁇ g, which can be the case, for example, in medicine or research.
  • DE 10 2013 220 416 A1 relates to a centrifuge having a swing-bucket rotor with centrifuge buckets suspended thereon.
  • a liquid to be centrifuged is tempered using electromagnetic waves.
  • the temperature of the liquid can be measured by means of a temperature sensor wetted by the liquid.
  • the measured temperature is then used to regulate the emitted electromagnetic waves, with which an exact specification of the temperature of the liquid can take place.
  • the temperature of a reference liquid rather than the temperature of the liquid to be centrifuged be measured.
  • Temperature sensors based on NTC elements or PTC elements or resistance temperature sensors are used as temperature sensors. It is also possible to use a passive RFID tag with a temperature indicator function.
  • the RFID tag can then be arranged on the centrifuge beaker or a holder in such a way that the signal from the RFID tag is not shielded. It is also proposed that a portion of the centrifuge bucket has a recess in which is placed a material which is transparent to electromagnetic radiation, for example a non-conductive material such as glass, plastic, polypropylene, polyethylene, quartz, polymers or ceramics.
  • An RFID receiver is arranged in the area of the centrifuge and can transmit the temperature information directly to the microwave control or possibly the centrifuge control in order to carry out a regulation in this way. Other information such as a phase change, data on the pH value, information on the rotational status of a stacked centrifugation system or general data for quality control can also be read out and checked using electromagnetic wave technology.
  • EP 2 623 206 A1 relates to a centrifuge with a swing-out rotor and centrifuge containers held thereon, which are used here for separating blood.
  • a sensor should be physical properties of the components of the blood during centrifugation be separated, be recorded.
  • the sensor is placed in a capsule with a glass shell in the shape of an ellipsoid or a sphere.
  • Four electrodes are arranged on the outside of the capsule, which form the sensors and are connected to a transponder in the capsule with lines.
  • the transponder of the capsule communicates with an evaluation unit, which is arranged outside the housing of the centrifuge.
  • the electrical energy for operating the transponder and the electrodes is transmitted from the evaluation unit to the transponder by means of an electromagnetic field.
  • the capsule is placed loosely in the centrifuge bowl directly into the blood. If sensors measure the electrical conductivity of the blood, the hematocrit value can be determined.
  • the measurement signals from the sensors can be transmitted to the evaluation unit from the transponder via antennas which are also arranged on the capsule. The transmitted signals are then evaluated in the evaluation unit. If a predetermined threshold value for the electrical conductivity of the blood is reached, the centrifugation is terminated.
  • the threshold value reached can be stored in the evaluation unit.
  • the transponder, the antenna, the data lines and power lines can be integrated into a wall of the centrifuge container.
  • EP 2 397 225 A2 proposes equipping a sample container with a label that reacts sensitively to the acceleration acting on the sample container and thus the sample by changing its state when the acceleration exceeds a threshold value.
  • a machine-readable one-dimensional or two-dimensional code or an alphanumeric code should be displayed.
  • the label it should then also be possible to recognize in a simple manner whether a sample container with a sample arranged therein has already gone through a centrifugation process or not.
  • the label it should be possible for the label to also display the magnitude of the acceleration or the approximate period of time during which the acceleration was above a threshold value.
  • the label can have further partial areas in which additional environmental parameters such as a temperature, a sample type or patient-related data can be displayed. It is also proposed that, in addition to the display dependent on the acceleration, a code that is not sensitive to acceleration is displayed on the label or that an RFID tag is present, which displays sample-related or patient-related data.
  • the object on which the invention is based is achieved by means of a method for operating a centrifuge container for a laboratory centrifuge, which has an RFID device (or a device with an RFID device).
  • RFID devices of the required quality can now be provided at reasonable prices.
  • the RFID device enables a wireless power supply and/or an exchange of information between the centrifuge container and adjacent components such as a rotor of the laboratory centrifuge or the laboratory centrifuge itself.
  • a memory unit for storing at least one operating variable. According to the invention, a number of the operating cycles which the centrifuge container has gone through are stored by the memory unit.
  • the invention takes this field of tension into account for one embodiment in that there is a coupling area for coupling the centrifuge container to a rotor, which predetermines an alignment of the centrifuge container with respect to an axis of rotation of the rotor. If the centrifuge container is used with a swing-bucket rotor, the orientation of the centrifuge container relative to the rotor can still change about the pivot axis oriented in the circumferential direction.
  • the coupling area specifies which side of the centrifuge container is arranged on the side facing the axis of rotation of the rotor and which side of the centrifuge container is arranged on the opposite side, which is arranged adjacent to the wall of the laboratory centrifuge, which delimits the centrifugation chamber of the laboratory centrifuge .
  • the device or a part thereof such as a circuit board with the electronic components excluding the antenna
  • the device (or part of it) has a small distance from the axis of rotation, which means that the acceleration forces acting on the device or parts of it are small, which on the one hand extends the working capacity of the device towards higher speeds and /or mechanical or electronic damage to the device can be avoided.
  • an antenna of the device is arranged on the side of the centrifuge container which faces away from the axis of rotation in the state in which the centrifuge container is coupled to the rotor.
  • further components of the device are arranged on the side of the centrifuge container which faces the axis of rotation. Components of the device are thus arranged on different sides of the centrifuge container and are preferably electrically coupled to one another.
  • the antenna of the device is exposed to relatively large accelerations as a result of the relatively large distance from the axis of rotation.
  • Other components of the device which are then arranged on the side facing the axis of rotation, but are stressed with smaller accelerations, which is advantageous for sensitive electrical or electronic components such as an electronic control unit or the RFID device and/or a sensor may be the case.
  • the centrifuge container there is also a coupling area for coupling the centrifuge container to a rotor, which specifies an alignment of the centrifuge container with respect to an axis of rotation of the rotor.
  • the antenna of the device (or even the entire device) is arranged on the side of the centrifuge container which, in the rotor-coupled state of the centrifuge container, faces the lid or the bottom of the laboratory centrifuge, which is preferably at a small distance from the axis of rotation takes place.
  • the antenna of the device can be excited and/or exchange information with a transmitting and/or receiving device, the antenna of which is arranged in the area of the base or the lid of the laboratory centrifuge.
  • the device has an antenna via which the device can be supplied with energy wirelessly from a power source which is arranged outside the centrifuge container.
  • This energy source can be a transmission device ensuring excitation, which is rotated with the rotor or is arranged fixed to the housing of the laboratory centrifuge and is arranged, for example, in the area of a wall delimiting a centrifugation chamber or even in the interior of the centrifugation chamber.
  • a sensor can count the number of operating cycles that the centrifuge container has gone through. In this way, it can be documented and checked in the device and by reading out the number of operating cycles, how many operating cycles the centrifuge container has gone through, so that the centrifuge container can be exchanged when a predetermined number of operating cycles has been reached. It is possible here for the number of operating cycles to be detected using measurement signals during centrifugation, in particular acceleration curves or when a maximum is reached or when a braking and/or acceleration process of the laboratory centrifuge is detected using a suitable sensor in the centrifuge container.
  • a counting pulse is sent to the RFID device via a transmitting and/or receiving device of the laboratory centrifuge when the centrifuge container with a rotor is inserted into the laboratory centrifuge, which pulse increases the current number of the counter by 1. It is alternatively or cumulatively possible for the laboratory centrifuge to send a counting pulse to the RFID device when a lid of the laboratory centrifuge is closed or a centrifugation process is started and/or ended and, for example, a threshold value for the rotor speed is exceeded. For example, it can be advantageous if no counting pulse is sent to the RFID device and this is processed by the RFID device if only one centrifuge container is inserted into the laboratory centrifuge and this is removed from the laboratory centrifuge again without centrifugation having taken place.
  • the centrifuge container or the RFID device can have a memory unit which enables at least one operating variable to be stored.
  • any operating variable can be stored in the memory unit, cf. the previously mentioned operating variables.
  • a cycle count can be stored in the memory unit, which indicates how many centrifugation cycles the centrifuge container equipped with the memory unit has already run through. The cycles can be counted by the centrifuge container itself be done by using an acceleration sensor of the centrifuge container, for example, to detect when a threshold value is exceeded when a centrifugation process is run through, so that a cycle counter reading is increased when the threshold value is exceeded.
  • the laboratory centrifuge can trigger an impulse to change the stored cycle counter reading of the centrifuge container and then transmit this impulse to the centrifuge container, where the cycle counter reading stored in the memory unit can then be increased by one.
  • the laboratory centrifuge can trigger a pulse when a lid is closed or when a centrifugation process is initiated or run through, for example when a rotor speed exceeds a threshold value.
  • the configuration according to the invention can contribute to the treatment of the following problem:
  • the centrifugation processes are counted by the laboratory centrifuge, assuming that the same centrifuge containers are always in the laboratory centrifuge can be used. If the number of counted centrifugation processes exceeds a threshold value, the user is signaled that the centrifuge container needs to be replaced or the laboratory centrifuge is even shut down.
  • Such monitoring of the number of centrifugation processes that a centrifuge container has gone through fails if different centrifuge containers are used with the laboratory centrifuge for different centrifugation processes or a centrifuge container is used in different laboratory centrifuges.
  • the number of continuous centrifugation processes can be counted by the RFID device for each centrifuge container itself, which then allows the use of any centrifuge container with a laboratory centrifuge and a specific display and monitoring of the number of continuous centrifugation processes of the respective centrifuge container is possible. It is also possible for the laboratory centrifuge to automatically detect whether the centrifuge containers arranged in the laboratory centrifuge have undergone a number of centrifugation processes that is less than a predetermined threshold value that ensures operational reliability.
  • An example of another operating variable detected by a sensor of the centrifuge container can be a centrifugation time, with which the process conditions of the products that have been centrifuged in the centrifuge container can be documented.
  • the device can be arranged anywhere inside or outside the centrifuge container or can be distributed to any desired location and connected to a housing of the centrifuge container or a cover of the same in any way, in particular by flanging, screwing, gluing, a latching or locking device or a positive connection or snap connection.
  • the device in particular at least the antenna, to be arranged in a recess of a component of the centrifuge container such as the housing.
  • the device in the recess can be covered by a radiation-transmissive cover element, so that electromagnetic radiation can pass through the radiation-transmissive cover element on the one hand for excitation and on the other hand for an exchange of information.
  • the device or the component thereof is protected on the one hand in the interior of the recess by the component of the centrifuge container, in particular the housing of the same, and on the other hand protected by the radiation-transmissive cover element, without the excitation and/or the exchange of information being significantly impaired.
  • the centrifuge container has a transmitting and/or receiving device.
  • Information from at least one sample container arranged in the centrifuge container can be received by means of the transmitting and/or receiving device.
  • the sample containers arranged in the centrifuge container can be blood bags, which are also equipped with an RFID device.
  • the information transmitted from the blood bag's RFID device to the centrifuge container's RFID device can be information that specifies the blood bag or the blood contained therein (e.g.
  • the information is information regarding the centrifugation process through which the blood bag and thus the centrifuge container is to go. This can be, for example, a maximum acceleration, a centrifugation time, a speed, a maximum temperature to which the blood in the blood bag may be exposed, a speed profile, and the like.
  • the at least one piece of information that is transmitted from the RFID device of the sample container to the RFID device of the centrifuge container can (with or without further processing) then be sent directly to a receiving device on the laboratory centrifuge or indirectly via a transmitting and/or receiving device on the rotor be transferred to the laboratory centrifuge.
  • the laboratory centrifuge uses this information for storage, for determining the operating parameters of the laboratory centrifuge so that the centrifugation process can be carried out in accordance with the transmitted information and/or for monitoring the centrifugation process.
  • the laboratory centrifuge can transmit information directly or indirectly via the rotor to the RFID device of the centrifuge container, which is then (without or with further processing) from the RFID device of the centrifuge container to the RFID device of the sample container transferred, where they can then be stored.
  • This information can be, for example, data on the centrifugation process (e.g. the date of the centrifugation process, parameters of the centrifugation such as a speed profile, duration, etc., results of the monitoring with an indication of any errors that have occurred or critical states, the temperatures, which have prevailed during the centrifugation in the centrifugation chamber or in the centrifuge container, generated accelerations, etc.).
  • the transmitting and/or receiving device used for the communication between the RFID device of the centrifuge container and the RFID device of the sample container can only be used for this communication. It is also possible, however, for the transmitting and/or receiving device to be used multifunctionally as the transmitting and/or receiving device for this communication, via which the RFID device of the centrifuge container communicates with the rotor or the laboratory centrifuge.
  • a further solution to the problem on which the invention is based is a method for operating a laboratory centrifuge in which a centrifuge container is used, in which there is a memory unit for storing at least one operating variable and a number of operating cycles which the centrifuge container (4) has gone through. stored by the storage unit.
  • the laboratory centrifuge has a rotor with at least one centrifuge container that is held, in particular suspended, on the rotor.
  • the laboratory centrifuge according to the invention has a transmitting and/or receiving device.
  • the transmitting and/or receiving device ensures (unidirectional or bidirectional) communication with a device of at least one centrifuge container held on a rotor. This communication can consist, on the one hand, in an excitation of the power supply device and/or, on the other hand, in an exchange of information.
  • the transmitting and/or receiving device of the laboratory centrifuge communicates with a rotor.
  • the rotor again communicates with a device of at least one centrifuge container held on a rotor.
  • the communication between the device of the centrifuge container and the rotor is simplified, since here at most relative movements occur as a result of the pivoting angle of the centrifuge container in relation to the rotor.
  • the relative arrangement of the transmitting and receiving device of the laboratory centrifuge relative to the rotor can then be selected in such a way that good communication is also ensured for this transmission path of the information.
  • an antenna can be placed on the rotor at a smaller distance from the axis of rotation than could be the case for the centrifuge bowl.
  • the transmitting and receiving device of the laboratory centrifuge can be arranged in any area of the laboratory centrifuge.
  • the transmitting and/or receiving device is preferably arranged directly on the wall of the laboratory centrifuge, which delimits a centrifugation chamber. It is also possible for this wall to have a radiation-permeable cover element in the area of the transmitting and/or receiving device, which is arranged between the centrifugation chamber and the transmitting and/or receiving device.
  • the transmitting and/or receiving device can be arranged in the area of a peripheral surface of the wall around the axis of rotation.
  • the transmitting and/or receiving device can be arranged in the area of a base of the centrifugation chamber or in the area of a cover of the laboratory centrifuge.
  • the possible locations for the arrangement of the transmitting and/or receiving device explained above can apply to the entire transmitting and/or receiving device or only to a transmitting and/or receiving antenna of the same.
  • Information from the laboratory centrifuge and/or the centrifuge container can be written to and/or read from a memory of the RFID device during operation of the laboratory centrifuge or when the rotor is at a standstill or in dedicated maintenance phases. It is possible within the scope of the invention for the laboratory centrifuge to have a control device. In this case, the control device has control logic, for example, which evaluates information from the transmitting and/or receiving device.
  • an evaluation can be made as to the number of centrifuge containers with which the rotor is equipped. If, for example, four receptacles for centrifuge containers are provided on a rotor and are distributed evenly over the circumference, equipping the rotor with only three centrifuge containers would lead to an imbalance, which would impair the operation of the laboratory centrifuge and even damage the laboratory centrifuge or even the area around the laboratory centrifuge can result. An evaluation of the number of centrifuge containers in the rotor thus provides important information for the process and operational reliability of the laboratory centrifuge.
  • an evaluation is carried out as to the type (or types) of centrifuge containers with which the rotor is equipped.
  • the evaluation can be used to detect whether an intended type or several intended types of centrifuge containers are used on the rotor. If this is not the case, there can also be an imbalance with the previously explained problems when rotating the rotor with the centrifuge containers. It is also possible that, for example, the rotor is not suitable for the non-intended type, which can be detected from the evaluation, with which suitable remedial measures can then be initiated.
  • the centrifugation profile ie the maximum speed, a speed profile, durations for individual speeds, etc.
  • the control logic can use the determined types of centrifuge containers that are held on the rotor to carry out an evaluation as to which centrifugation profile the at least one type of centrifuge container must be used to carry out the centrifugation process, and the drive unit can then be controlled accordingly the laboratory centrifuge to carry out the centrifugation process with the centrifugation profile specific to that type or types.
  • the control device preferably has control logic which, in the event that the evaluation of the information from the transmitting and/or receiving device shows that the rotor is not equipped with the required number of centrifuge containers and/or the rotor is not of the correct type or correct types of centrifuge containers, generates an error signal and/or restricts or prevents operation of the laboratory centrifuge.
  • an optical or acoustic error signal can be generated which signals to the user of the laboratory centrifuge that the required number of centrifuge containers is not provided on the rotor or an impermissible type of centrifuge containers is used in connection with the rotor and the laboratory centrifuge.
  • a suitable error indication can be generated on a display of the laboratory centrifuge.
  • operation of the laboratory centrifuge is restricted, so that, for example, if the number of centrifuge containers is incorrect or the type of centrifuge container is incorrect, the maximum permissible speed of the rotor is adjusted. It is possible, for example, that in a characteristic map of the laboratory centrifuge is stored, for which number of centrifuge containers and/or which type of a recognized centrifuge container which maximum speed is permissible or which type of centrifugation profile is to be used.
  • one or the aforementioned control device has control logic that generates a signal that is dependent on the number of operating cycles that the centrifuge container has run through.
  • This embodiment is based on the knowledge that a centrifuge container must be serviced or replaced after a predetermined number of operating cycles.
  • the number of operating cycles completed is recorded for each centrifuge container by means of the associated device, in particular in the form of a counter.
  • a threshold value for the number of operating cycles is then exceeded, this can be signaled by the laboratory centrifuge, in particular via a display or a warning tone. It is also possible here for a multi-stage signaling to the user to take place, in which case, for example, a color code corresponding to a traffic light green, yellow, red can also be used. In this case, a green tint signals that the centrifuge bowl is safe to operate, a yellow tint signals that the centrifuge bowl will need maintenance or replacement soon, and a red tint signals that the centrifuge bowl has reached its maximum number of operating cycles and needs maintenance or the centrifuge bowl needs to be replaced. It is also possible that the operation of the laboratory centrifuge is stopped when a maximum number of operating cycles is reached.
  • a centrifuge container arranged in the laboratory centrifuge can be checked, via a corresponding input device of the laboratory centrifuge, how many operating cycles the centrifuge container has already run through.
  • the laboratory centrifuge can also display a display such as "centrifuge bowl 123 has reached 76% of its life", where "123" is an identifier specific to the centrifuge bowl.
  • the transmission and/or receiving device has a ring segment or ring antenna, which is arranged in the area of a cover of the laboratory centrifuge or a base of the laboratory centrifuge and extends concentrically to the axis of rotation over at least a partial circumference or the entire circumference.
  • the device of the centrifuge container and in particular an antenna of the same can be moved closely adjacent to the ring segment or ring antenna with the rotation of the laboratory centrifuge, with not only a temporary communication of the antenna of the RFID device with an antenna of the transmitting and / or Receiving device takes place in a specific circumferential angle, but communication over all angles of rotation (or a large range of rotation angles) is possible as a result of the use of the ring antenna.
  • the ring segment or ring antenna can be arranged concentrically or eccentrically to the axis of rotation.
  • any other antenna for example a plate antenna, a cable antenna or a rod antenna, in which case these can be arranged concentrically to the axis of rotation or eccentrically thereto.
  • a cable antenna or other antenna can be elliptical, rectangular or have any shape, in which case the antenna is then preferably arranged in a plane transverse to the axis of rotation and/or arranged concentrically or eccentrically to the axis of rotation can be. Investigations on which the invention is based have shown that, as a result of the reflections occurring in the stainless steel tank of the laboratory centrifuge, in some applications it can even be more favorable if the antenna is arranged eccentrically to the axis of rotation.
  • one or the control device has control logic that limits communication and/or evaluation of information to operating ranges in which the rotor is at a standstill.
  • the communication and/or the evaluation it is also possible for the communication and/or the evaluation to be limited to operating ranges in which the rotational speed of the rotor is lower than a predefined rotational speed threshold value. This threshold value of the rotational speed is determined in such a way that a reliable transmission of information between the RFID device and the transmitting and/or receiving device is ensured.
  • a further solution to the problem on which the invention is based is a method for operating a centrifuge container, which is a centrifuge container in which there is a storage unit for storing at least one operating variable and a number of operating cycles that the centrifuge container has run through, stored by the storage unit.
  • the same centrifuge container is used in several centrifugation processes, with the centrifuge container not always being operated in the same laboratory centrifuge, but in at least two laboratory centrifuges of the same type or of different types.
  • the invention is based on the finding that when the centrifuge container is operated alternately in different laboratory centrifuges, it is not possible for the laboratory centrifuge itself to count the cycles of the centrifugation processes to which the centrifuge container was subjected. According to the invention it is proposed that the centrifuge container is first introduced into a first laboratory centrifuge. A pulse for a cycle counter is then generated before, with or after a centrifugation process is run through.
  • This pulse can be generated, for example, by evaluating an acceleration of the centrifuge container, by opening or closing a lid of the laboratory centrifuge, or by the control unit of the laboratory centrifuge as the centrifugation process is run through.
  • the impulse is then transmitted to the centrifuge container, whereby the aforementioned communication types and ways can be used.
  • a cycle counter reading is stored in the storage unit of the centrifuge container, which represents how many cycles the centrifuge container has already run through. When the centrifuge container is used for the first time for a centrifugation process, the cycle counter reading is therefore set to zero. As a result of the pulse, the cycle count is incremented by one. The increased cycle count is then stored in the storage unit of the centrifuge container.
  • centrifuge container is then placed in a second laboratory centrifuge, a pulse for a cycle counter is generated by the second laboratory centrifuge (according to the explanations above) before, with or after running through a centrifugation process with the centrifuge container in the second laboratory centrifuge.
  • the pulse then results in an increment of the cycle count stored by the memory unit of the centrifuge bowl.
  • the increased cycle count is then stored on the Storage unit of the centrifuge container.
  • the cycle counter reading stored on the memory unit of the centrifuge container accurately reflects the cycles of centrifugation processes run through by the centrifuge container, regardless of the laboratory centrifuge in which the centrifuge container was used.
  • the cycle counter reading stored in the memory unit in this way can be used, for example, as follows: When the centrifuge container is placed in a laboratory centrifuge, the cycle counter reading can be read from the control unit of the laboratory centrifuge. If the cycle count is greater than a threshold value, a centrifugation process can be blocked in order not to unduly stress the centrifuge container. Alternatively or cumulatively, an optical or acoustic display can be generated on the laboratory centrifuge in order to signal to the user that the centrifuge container has run through a maximum number of cycles. In this case, the control unit of the laboratory centrifuge can compare the cycle counter reading with predetermined threshold values of the cycle counter reading that are available on the laboratory centrifuge.
  • the maximum number of cycles for the centrifuge container is stored in the RFID device of the centrifuge container, that this is read out by the control unit of the laboratory centrifuge and that the control unit of the laboratory centrifuge compares the current cycle counter reading with the specific threshold value read out for the maximum number of cycles.
  • the laboratory centrifuge 1 shows a laboratory centrifuge 1 in a rough schematic diagram.
  • a centrifugation chamber 2 of the laboratory centrifuge 1 there is a motor-driven rotor 3 on which several centrifuge containers 4a, 4b, ... (which are also referred to as "centrifuge buckets" in some embodiments) held, especially hung.
  • the laboratory centrifuge 1 has a transmitting and/or receiving device 5 , preferably adjacent to the centrifugation chamber 2 .
  • the laboratory centrifuge 1 has a control device 6 and an output device 7 , which is preferably a display 8 .
  • the device 9 has at least one antenna 10.
  • One antenna can be used for the unidirectional or bidirectional exchange of information, while another antenna is used to stimulate the energy supply. However, it is also possible for the exchange of information and the initiation of the energy supply to be ensured via the same antenna 10 .
  • the device 9 has an RFID device 11.
  • the device 9 can also have at least one sensor 12 for detecting an operating variable of the centrifuge container 4.
  • the antenna 10, the RFID device 11 and the sensor 12 are designed in the usual way and connected to one another. These can form a unit be combined or distributed and connected to one another via electrical connecting lines. It is possible for the RFID device 11 and/or the sensor 12 to be arranged on a circuit board 13. It is possible, for example, for the RFID device 11 and/or the sensor 12, in particular on the circuit board 13, to be at a small distance from an axis of rotation of the laboratory centrifuge 1 are arranged so that they are exposed to the smallest possible accelerations.
  • the antenna 10 can be freely positioned in such a way that optimal communication with the transmitting and/or receiving device 5 of the laboratory centrifuge 1 results.
  • the antenna 10 can be arranged at a location which has the smallest possible distance from the transmitting and/or receiving device 5, for which purpose the antenna 10 is preferably arranged at a small distance from a wall 14 that delimits the centrifugation chamber 2 .
  • the antenna 10 can be arranged at a small distance from a vertical, in particular cylindrical side wall or from the base or the cover of the centrifugation chamber 2 .
  • an exchange 15 of information and an excitation 16 between the antenna 10 of the device 9 of the centrifuge container 4 and an antenna 17 of the transmitting and/or receiving device 5 are shown in dots.
  • a communication 18 between the antennas 10, 17 can consist of the exchange 15 of information and/or the excitation 16, whereby an exchange 15 and an excitation 16 can also take place simultaneously or the exchange 15 and the excitation 16 alternately and in different operating phases can take place.
  • a laboratory centrifuge 1 Operation of a laboratory centrifuge 1 according to FIG 1 explained.
  • the rotor 3 with the centrifuge containers 4 is inserted into the centrifugation chamber 2 and a drive connection to the drive of the laboratory centrifuge 1 is created.
  • an identification of the associated centrifuge container 4 is stored in a memory unit.
  • This identifier can denote the type of centrifuge container 4 used, which means that several centrifuge containers 4 of the same type have the same identifier. It is alternatively or additionally possible for an identifier to be stored in the form of an identifier specific to each centrifuge container 4 .
  • the control software of the same generates a control unit 20 of the transmitting and/or receiving device 5 an excitation 16 for the purpose of supplying energy to the transmitting and/or receiving device 19.
  • the memory can be read and an exchange 15 of information, here the read identification, can take place .
  • the identifier transmitted in this way is then transmitted to the control device 6, which carries out an evaluation.
  • This evaluation can consist, for example, of checking whether the type of centrifuge container 4 that correlates with the identification is correct for the laboratory centrifuge 1 or the selected centrifugation process.
  • centrifuge container 4 It is also possible to check whether the correct number of centrifuge containers 4 are suspended from the rotor 3 . It is alternatively or additionally possible for the counter reading of a counter of the device 9, which is used to count how many centrifugation processes the centrifuge container 4 has gone through, to be read out. If the check shows that the intended type of centrifuge containers 4 is present and the correct number of centrifuge containers 4 is suspended from the rotor 3 and/or the counter readings of the centrifuge containers 4 used are less than the maximum number of centrifugation processes that the centrifuge containers 4 are allowed to run through, the centrifugation process is enabled by the control unit 6 .
  • an exchange 15 of information takes place between the transmitting and/or receiving devices 5, 19, in that a counting pulse for carrying out a further centrifugation process is transmitted to the transmitting and/or receiving device 19 of the centrifuge container 4, so that a stored current count of a counter of the device 9 for the number of centrifugation processes to which the centrifuge container 4 was exposed can be increased by 1.
  • information can then be exchanged 15 in the form of a currently determined or temporarily stored measured value of the sensor 12 to the transmitting and/or receiving device 5, with subsequent processing by the control device 6.
  • An exchange 15 of information in the form of the current counter reading preferably takes place before or after a centrifugation process.
  • the control device 6 compares the current count with a threshold value. If the control device 6 recognizes on the basis of this comparison that the maximum permissible count has been reached, the control device 6 generates an output on the display 8 such that the user is signaled that the centrifuge container 4 has run through the maximum number of permissible centrifugation processes. In this case, the control device 6 preferably also generates an output on the display 8 which identifies the centrifuge container 4 among the plurality of in the laboratory centrifuge 1 arranged centrifuge container 4 allows what is done in particular by displaying the specific for the centrifuge container 4 identification.
  • the RFID device 11 and the sensor 12 are not arranged on a common circuit board 13 here. Rather, the antenna 10 and the RFID device 11 form a structural unit 21 here, while the sensor 12 is designed separately and is also arranged at a distance from the structural unit 21 under certain circumstances.
  • the communication 18 of the transmitting and/or receiving device 19 of the centrifuge container 4 does not take place with the transmitting and/or receiving device 5 of the laboratory centrifuge 1, but rather with a transmitting and/or receiving device 22 of the rotor 3.
  • This can, for example have an antenna 23, via which the communication 18 takes place, and a control device 24 for controlling any excitation 16 and/or an exchange 15.
  • the transmitting and/or receiving device 22 of the rotor 3 is in communication 25 with the transmitting and /or receiving device 5 of the laboratory centrifuge 1.
  • This communication 25 can be wired, for example via a sliding contact between the rotor 3 and the laboratory centrifuge 1.
  • the communication 25 also takes place wirelessly.
  • the transmitting and/or receiving device 22 has an antenna 26, via which the communication 25 with the antenna 17 of the transmitting and/or receiving device 5 takes place.
  • FIG. 3 shows highly schematized the laboratory centrifuge 1 with the rotatably mounted and driven rotor 3 about an axis of rotation 27 and centrifuge containers 4a, 4b, ... suspended thereon about pivot axes 28a, 28b, ...
  • the centrifugation chamber 2 is closed with a cover 29 .
  • a ring antenna 30 is held on the cover 29 on the side facing the centrifugation chamber 2 .
  • the ring antenna 30 is arranged concentrically to the axis of rotation 27 and at a small distance from the devices 9a, 9b, ... and the antennas 10a, 10b, ... of the same to enable short transmission paths.
  • the antenna 10 is connected to the sensor 12 via a branch 31 in a first line branch 32 via a first filter 33 . Furthermore, the antenna 10 is connected to the RFID device 11 via the branch 31 in a second line branch 34 via a second filter 35 .
  • the first line branch 32 has a demodulator 36 (effective in the direction from the antenna 10 to the sensor 12) and a modulator 37 (effective in the direction from the sensor 12 to the antenna 10), the demodulator 36 and the modulator 37 preferably being between the filter 33 and the sensor 12 are arranged. It is possible for the demodulator 36 and/or the modulator 37 to have a diode 38 with a downstream low-pass filter or a capacitor.
  • the first filter 33 is preferably a high-pass filter, while the second filter 35 is a low-pass filter.
  • the high-pass and the low-pass do not overlap in terms of their consistency.
  • the filters 33, 35 may be in the form of bandpass filters without overlapping.
  • the branch 31 and the filters 33, 35 to be formed by a frequency filter or a so-called diplexer, to the input of which the antenna 10 is connected and to the outputs of which the sensor 12 and the RFID device 11 are connected.
  • the senor 12 forms a system capable of oscillating, the oscillating circuit of the sensor 12 being designed with a quartz 39 . Due to the temperature dependence of the behavior of the quartz 39, the resonant frequency of the oscillating circuit depends on the temperature to which the sensor 12 is exposed, with the result that the sensor 12 is a temperature sensor.
  • the RFID device 11 has a memory 40 .
  • a parameter 41 specific to the centrifuge container 4 is stored in the memory 40 .
  • the parameter 41 enables the associated centrifuge container 4 to be uniquely identified.
  • the parameter 41 can be, for example, a serial number or a serial or product number.
  • the parameter 41 is a calibration parameter that can describe the behavior of the sensor 12, here the specific dependence of the resonant frequency on the temperature acting on the quartz 39.
  • Such a parameter can be, for example, a calibration factor, a calibration curve, a calibration function or a calibration characteristic map.
  • a device 9 according to 4 enables the following mode of operation: If an excitation 16 of the device 9 occurs with an excitation frequency which can pass the second filter 35 but does not pass the first filter 33, a power supply to the RFID device 11 can be ensured via this excitation, and an exchange 15 of information, here the parameter 41.
  • the oscillating circuit of the sensor 12 formed with the quartz 39 has a temperature-dependent resonant frequency.
  • the resonant circuit is excited to oscillate at the resonant frequency by means of excitation 16, with the resonant circuit being designed in such a way that in the expected temperature range the resonant frequency is in a frequency range that enables excitation to resonate with an excitation frequency of excitation 16, which is the first Filter 33 can pass, but the second filter 35 does not happen.
  • the temperature can be determined using the transmitting and/or receiving device 5 or 22 by varying the excitation frequency and searching for the resonance using a calibration parameter that describes the dependence of the resonance frequency on the temperature.
  • An excitation 16 can preferably have a carrier frequency in the range from 2.4 GHz to 2.5 GHz, while the resonant frequency of the resonant circuit of the sensor 12 can be in a range from 32 KHz to 67 KHz or 170 KHz to 250 KHz.
  • the RFID device 11 is excited at a frequency of 868 MHz or 915 MHz, with changes of ⁇ 5% or ⁇ 10% of these frequencies also being possible. If several centrifuge containers 4 with associated sensors are used in a laboratory centrifuge 1 or in several laboratory centrifuges 1, the oscillating circuits of the sensors 12 can have resonance frequencies in different, non-overlapping resonance frequency ranges.
  • the centrifuge container 4 is preferably coupled to the rotor 3 in the area of the pivot axis 28 via a coupling area 42, which specifies an alignment of the centrifuge container 4 relative to the axis of rotation 27 in such a way that the centrifuge container 4 only has one predetermined side facing the axis of rotation 27 , can be coupled with the rotor 3.
  • an antenna 17 of the laboratory centrifuge can be designed as a cable antenna, for which purpose a so-called Locfield antenna ("LOCFIELD" is a registered trademark) is preferred.
  • LOCFIELD Locfield antenna
  • a length in the range of 0.5 m to 1.5 m or 0.8 m to 1.2 m can be used.
  • the cable antenna can then be integrated into the cover 29, for which purpose the cover 29 has a part-ring-shaped or ring-shaped groove or recess, in which the cable antenna extends over part of the circumference or over the entire circumference around the axis of rotation 27 .
  • a plate antenna which is integrated in particular in a recess in the cover and is preferably covered in a protective and/or sealing manner in the direction of the centrifugation chamber 2 .
  • Communication with at least one of the aforementioned antennas integrated in the cover 29 preferably takes place using UHF frequencies.
  • the antenna 17 can communicate with a sample container, such as a blood bag, for example with the interposition of a transmitting and/or receiving device of the centrifuge container 4 and/or the rotor 3, preferably by means of communication with an RFID device of the sample container .
  • a sample container such as a blood bag
  • the control unit 20 of the laboratory centrifuge 1 for example the type of sample, a type designation of the sample, a specific sample number of the sample, the date the sample container was filled, etc.
  • This information can are then displayed for the user on a display of the laboratory centrifuge 1 or are stored by the laboratory centrifuge 1 or externally from this.

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Claims (16)

  1. Procédé de fonctionnement d'un récipient de centrifugeuse (4) pour une centrifugeuse de laboratoire (1), dans lequel le récipient de centrifugeuse (4) comprend un dispositif RFID (11), dans lequel une unité de mémoire est prévue pour l'enregistrement d'une grandeur de fonctionnement, caractérisé en ce qu'un nombre de cycles de fonctionnement que le récipient de centrifugeuse (4) a effectué est enregistré par l'unité de mémoire.
  2. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon la revendication 1, caractérisé en ce que
    a) une zone de couplage (42) est prévue pour un couplage du récipient de centrifugeuse (4) avec un rotor (3), qui impose une orientation du récipient de centrifugeuse (4) par rapport à un axe de rotation (27) du rotor (3) et
    b) un dispositif (9) comprenant un dispositif RFID (11) est disposé au moins partiellement sur le côté du récipient de centrifugeuse (4) qui est orienté vers l'axe de rotation (27) lorsque le récipient de centrifugeuse (4) est dans un état couplé avec le rotor (3).
  3. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon la revendication 2, caractérisé en ce que
    a) une antenne (10) du dispositif (9) est disposée sur le côté du récipient de centrifugeuse (4) qui est opposé à l'axe de rotation (27) lorsque le récipient de centrifugeuse (4) est dans un état couplé avec le rotor (3) et
    b) d'autres composants du dispositif (9) sont disposés sur le côté du récipient de centrifugeuse (4) qui est orienté vers l'axe de rotation (27) lorsque le récipient de centrifugeuse (4) est dans un état couplé avec le rotor (3).
  4. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon la revendication 1 ou 2, caractérisé en ce que
    a) une zone de couplage (42) est prévue pour un couplage du récipient de centrifugeuse (4) avec un rotor (3), qui impose une orientation du récipient de centrifugeuse (4) par rapport à un axe de rotation (27) du rotor (3) et
    b) une antenne (10) du dispositif (9) ou du dispositif RFID (11) est disposée sur le côté du récipient de centrifugeuse (4) qui est orienté vers le couvercle ou le fond de la centrifugeuse de laboratoire (4) lorsque le récipient de centrifugeuse (4) est dans un état couplé avec le rotor (3).
  5. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon l'une des revendications précédentes, caractérisé en ce que le dispositif (9) ou le dispositif RFID (11) comprend une antenne (10) par l'intermédiaire de laquelle le dispositif RFID (11) peut être alimentée en énergie sans fil, qui est disposée à l'extérieur du récipient de centrifugeuse (4).
  6. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon l'une des revendications précédentes, caractérisé en ce qu'au moins un capteur (12) est prévu pour la mesure d'une grandeur de fonctionnement.
  7. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon la revendication 6, caractérisé en ce que
    a) une durée de centrifugation et/ou
    b) une vitesse angulaire de rotation du récipient de centrifugeuse (4) et/ou
    c) une accélération du récipient de centrifugeuse (4) et/ou
    d) un angle d'oscillation du récipient de centrifugeuse (4) et/ou
    e) une température
    est mesurée par le capteur (12) et/ou enregistré par l'unité de mémoire.
  8. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon l'une des revendications précédentes, caractérisé en ce que le dispositif (9) ou le dispositif RFID (11) est disposé au moins partiellement dans un évidement d'un élément de la structure du récipient de centrifugeuse (4) et est recouvert d'un élément de recouvrement perméable aux rayonnements.
  9. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon l'une des revendications précédentes, caractérisé en ce que le dispositif (9) ou le dispositif RFID (11) comprend un dispositif d'émission et/ou de réception par l'intermédiaire duquel le dispositif RFID (11)
    a) peut recevoir des informations provenant d'au moins un récipient d'échantillon contenu dans le récipient de centrifugeuse (4) et/ou
    b) peut envoyer des informations à au moins un récipient d'échantillon contenu dans le récipient de centrifugeuse (4).
  10. Procédé de fonctionnement d'une centrifugeuse de laboratoire (1) avec au moins un récipient de centrifugeuse (4) fixé au rotor (3), qui fonctionne grâce à un procédé selon l'une des revendications précédentes, caractérisé en ce que la centrifugeuse de laboratoire (1) comprend un dispositif d'émission et/ou de réception (5) pour une communication (18) avec
    a) un dispositif (9) ou un dispositif RFID (11) d'au moins un récipient de centrifugeuse (4) fixé sur le rotor (3), pour l'exécution d'un procédé selon l'une des revendications précédentes et/ou
    b) un rotor (3), qui communique avec un dispositif (9) ou un dispositif RFID (11) d'au moins un récipient de centrifugeuse (4) fixé au rotor (3), pour l'exécution d'un procédé selon l'une des revendications précédentes.
  11. Procédé de fonctionnement d'une centrifugeuse de laboratoire (1) selon la revendication 10, caractérisé en ce qu'un dispositif de commande (6) est prévu qui comprend une logique de commande qui effectue une analyse des informations du dispositif d'émission et/ou de réception (5)
    a) avec quel nombre de récipients de centrifugeuse (4a, 4b...) le rotor (3) est équipé et/ou
    b) avec quel type ou quels types de récipients de centrifugeuse (4a, 4b...) le rotor (3) est équipé et/ou
    c) si le rotor (3) est équipé du nombre nécessaire de récipients de centrifugeuse (4a, 4b...) et/ou
    d) si le rotor (3) est équipé du bon type ou des bons types de récipients de centrifugeuse (4a, 4b...) et/ou
    e) avec quel profil de centrifugation pour l'au moins un type de récipient de centrifugeuse (4a, 4b,...), avec lequel ou lesquels le rotor (3) est équipé, le processus de centrifugation doit être effectué.
  12. Procédé de fonctionnement d'une centrifugeuse de laboratoire (1) selon la revendication 11, caractérisé en ce qu'un ou le dispositif de commande (6) comprend une logique de commande qui, dans le cas où l'analyse d'informations du dispositif d'émission et/ou de réception (5) indique que
    a) le rotor (3) n'est pas équipé du nombre nécessaire de récipients de centrifugeuse (4a, 4b...) et/ou
    b) si le rotor (3) n'est pas équipé du bon type ou des bons types de récipients de centrifugeuse (4a, 4b...),
    génère un signal d'erreur et/ou limite ou empêche un fonctionnement de la centrifugeuse de laboratoire (1).
  13. Procédé de fonctionnement d'une centrifugeuse de laboratoire (1) selon l'une des revendications 10 à 12, caractérisé en ce qu'un ou le dispositif de commande (6) comprend une logique de commande qui génère un signal qui dépend du nombre de cycles de fonctionnement que le récipient de centrifugeuse (4) a effectués.
  14. Procédé de fonctionnement d'une centrifugeuse de laboratoire (1) selon l'une des revendications 10 à 13, caractérisé en ce que le dispositif d'émission et/ou de réception (5) comprend, pour la communication (18) avec au moins un réception de centrifugeuse (4) fixé à un rotor (3), une antenne annulaire (30) qui est disposée au niveau d'un couvercle (29) de la centrifugeuse de laboratoire (1) ou d'un fond d'une chambre de centrifugation (2) de la centrifugeuse de laboratoire (1).
  15. Procédé de fonctionnement d'une centrifugeuse de laboratoire (1) selon l'une des revendications 10 à 14, caractérisé en ce qu'un ou le dispositif de commande (6) comprend une logique de commande qui limite une communication (18) et/ou une analyse à des zones de fonctionnement
    a) avec une immobilisation et/ou
    b) avec des vitesses de rotation inférieures à une valeur seuil de la vitesse de rotation.
  16. Procédé de fonctionnement d'un récipient de centrifugeuse (4) selon l'une des revendications 1 à 9, dans plusieurs processus de centrifugation dans au moins deux centrifugeuses de laboratoire (1), plus particulièrement avec l'exécution de procédés selon l'une des revendications 10 à 15, dans les au moins deux centrifugeuses de laboratoire (1), avec les étapes suivantes :
    a) introduction du récipient de centrifugeuse (4) dans une première centrifugeuse de laboratoire (1a),
    b) génération d'une impulsion pour un compteur de cycles,
    c) augmentation d'un état du compteur de cycles enregistré par une unité de mémoire du récipient de centrifugeuse (4), à la suite de l'impulsion générée,
    d) enregistrement de l'état de compteur de cycles augmenté sur l'unité de mémoire du récipient de centrifugeuse (4),
    e) introduction du récipient de centrifugeuse (4) dans une deuxième centrifugeuse de laboratoire (1b),
    f) génération d'une impulsion pour un compteur de cycles,
    g) augmentation de l'état du compteur de cycles enregistré par l'unité de mémoire du récipient de centrifugeuse (4), à la suite de l'impulsion générée,
    h) enregistrement de l'état de compteur de cycles augmenté sur l'unité de mémoire du récipient de centrifugeuse (4).
EP19163817.0A 2018-03-28 2019-03-19 Centrifuge de laboratoire, récipient centrifuge pour une centrifuge de laboratoire et procédé de fonctionnement d'un récipient centrifuge Active EP3560592B1 (fr)

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DE102022124726A1 (de) * 2022-09-26 2024-03-28 Thermo Electron Led Gmbh Zentrifuge und verfahren zum betrieb einer zentrifuge
EP4434637A1 (fr) 2023-03-23 2024-09-25 Sigma Laborzentrifugen GmbH Dispositif de fixation de centrifugeuse de laboratoire, ensemble capteur de centrifugeuse de laboratoire, unité de rotor de centrifugeuse de laboratoire, procédé de montage d'une unité de rotor de centrifugeuse de laboratoire et procédé de fonctionnement d'une centrifugeuse de laboratoire
EP4434636A1 (fr) 2023-03-23 2024-09-25 Sigma Laborzentrifugen GmbH Ensemble de produit de fermentation de centrifugeuse de laboratoire, produit de fermentation de mesure et centrifugeuse de laboratoire

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EP3560592A2 (fr) 2019-10-30
DE202018101760U1 (de) 2019-07-01

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