EP3534873A1 - Cream for sensitive skin, comprising aloe vera and an extremely low content of preservatives - Google Patents
Cream for sensitive skin, comprising aloe vera and an extremely low content of preservativesInfo
- Publication number
- EP3534873A1 EP3534873A1 EP17745327.1A EP17745327A EP3534873A1 EP 3534873 A1 EP3534873 A1 EP 3534873A1 EP 17745327 A EP17745327 A EP 17745327A EP 3534873 A1 EP3534873 A1 EP 3534873A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- aloe vera
- weight
- preparations
- preservatives
- emulsifiers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/33—Free of surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Definitions
- the present invention relates to cosmetic or dermatological preparations containing active ingredients for the care and protection of the skin and the use of such active ingredients and combinations of such active ingredients in the field of cosmetic and dermatological skin care.
- the present invention relates to a cream for sensitive skin with aloe vera and the lowest possible content of preservatives.
- the effect of ointments and creams on the barrier function and the hydration of the horny layer is based essentially on the coverage (occlusion) of the treated skin areas.
- the choice of the appropriate skin care product for sensitive skin is particularly important.
- the cosmetic should not additionally irritate or strain the skin. It is important that the raw materials used are particularly mild and compatible. Special attention should be paid to the type and amount of preservatives used, as these often lead to intolerances and / or allergies.
- Specific Active ingredients contained in the cream are said to soothe and protect the skin, such as vitamin E, aloe vera, panthenol, chamomile or bisabolol.
- Emulsions are generally understood to mean heterogeneous systems which consist of two liquids which are immiscible or only slightly miscible with one another, which are usually referred to as phases, and in which one of the two liquids is dispersed in the form of very fine droplets in the other liquid. Viewed externally and with the naked eye, emulsions appear homogeneous.
- the two liquids are water and oil and the oil droplets are finely dispersed in the water, then it is an oil-in-water emulsion (O / W emulsion, for example, milk).
- O / W emulsion for example, milk
- the basic character of the O / W emulsion is characterized by water.
- a water-in-oil emulsion (W / O emulsion, e.g., butter) is the reverse principle, with the basic character here being determined by the oil.
- emulsifier In emulsions, the choice of a suitable emulsifier prevents phase separation.
- Hydrodispersions are dispersions of a liquid, semi-solid or solid internal (discontinuous) lipid phase in an external aqueous (continuous) phase.
- hydrodispersions are essentially free of emulsifiers.
- Hydrodispersions, as well as emulsions, are metastable systems and are prone to transition to a state of two contiguous discrete phases.
- Preservatives are antimicrobial substances which are added in the manufacturing process to a product (food, pharmaceutical, cosmetic or chemical preparation) in small amounts (usually between about 0.0005% and 1% active content, depending on the product). Preservatives are intended to protect products during manufacture, storage and use from contamination by microorganisms, in particular from microbial adverse changes.
- a preservative is generally subject to the following requirements: It must be sufficiently antimicrobial effective, technologically applicable and harmless to health. Of course, the finished preparation - the commercial product - health harmless. It should be noted that microorganisms in z. As cosmetic products primarily due to production or secondary can pass through the consumer in the cosmetic products.
- preservatives proposed or proposed for preservation are bacteriostatic and fungistatic, sometimes also bactericidal and fungicidal: they should be, as far as possible, odorless, tasteless and, in the doses used, soluble, non-toxic, skin tolerant and sufficiently effective.
- the preservatives must be dissolved in the raw or auxiliary to be preserved.
- a sterility is generally not required for a cosmetic preparation, it must be free from pathogenic germs and be protected against microbial changes.
- preservatives or preservatives common in cosmetics are dibromodicyanobutane (2-bromo-2-bromomethylglutarodinitrile), 3-iodo-2-propynyl-butylcarbamate, 2-bromo-2-nitro-propane-1,3-diol, imidazolidinyl urea, Chloro-2-methyl-4-isothiazolin-3-one, 2-chloroacetamide, benzalkonium chloride, benzyl alcohol.
- compositions are furthermore, for example, formaldehyde releasers (for example
- DMDM hydantoin which is available, for example, under the trade name Glydant TM from Lonza, or imidazolidinyl urea), iodopropyl butylcarbamates (for example those available under the trade names Glycacil-L, Glycacil-S from Lonza and / or Dekaben LMB by Jan Dekker), parabens (ie, p-hydroxybenzoic acid alkyl esters, such as methyl, ethyl, propyl and / or butylparaben), phenoxyethanol, ethanol, benzoic acid and the like.
- the preservation system according to the invention also advantageously also preserving aids, such as octoxyglycerol, glycine soy etc.
- z. B. be because most preservatives are better fat than water-soluble, so that z.
- the preservative incorporated into the aqueous phase migrates in the course of storage in the fatty phase and thus the preservation of the aqueous phase is in question.
- this problem is solved by using a combination of preservatives. So z.
- the aqueous phase with a readily water-soluble preservative, the fat phase are preserved simultaneously with a fat-soluble preservative.
- the preservative effect of individual preservatives depends on the composition and physical properties of the preparation to be preserved, with interactions between the preservative, the active
- various active ingredients or adjuvants such as aloe vera
- hydrocolloids concentration-dependent preservatives can hinder their antimicrobial activity and that finally - again in Depending on the concentration and type of preservative - the stratum corneum adsorbs the preservative and the preservative may then penetrate and absorb through the skin could be.
- Preservatives may cause skin irritation in people with chronic barrier damage (sensitive skin). In addition, consumers today pay much more attention to the fact that cosmetics consume contained in the product. The lowest possible dosage of the preservatives used is therefore desirable.
- Aloe vera is one of the old and long-tested medicinal plants. Aloe vera gel should be effective on the outside for wounds, burns, skin irritation, radiation damage and atopic dermatitis.
- aloe vera In cosmetics, the moisturizing effect of aloe vera gel has long been used for skin care products. The problem, however, is that aloe vera greatly affects the preservability of skin care products in general.
- the object of the present invention was therefore to solve the problems of the prior art, to enrich the state of the art and to produce cosmetic or dermatological preparations with a content of Aloe vera extracts which have sufficient microbiological stability with the lowest possible content of preservatives.
- Preparations according to the invention are extremely satisfactory preparations in every respect. Despite low concentration of phenoxyethanol and Ethylhexylglycerin and on the waiver of other substances used as antimicrobially effective preparations are resistant to the infestation of microorganisms.
- hydrodispersions require a lower level of preservatives than O / W emulsions.
- Cosmetic or dermatological preparations according to the invention preferably contain from 0.001 to 10% by weight, preferably from 0.005 to 5, particularly preferably from 0.01 to 1% by weight, of one or more aloe vera extracts and / or derivatives thereof the total composition of the preparations.
- Oils such as triglycerides of capric or caprylic acid, further natural oils such as e.g. Castor oil;
- Fats, waxes and other natural and synthetic fats preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
- Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.
- the oil phase of the hydrodispersions according to the invention can also be advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms.
- ester oils can then advantageously be chosen from the group octyl palmitate, octyl cocoate, octyl isostear, octyl dodecyl myristate, cetearyl sononanoate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate,
- the oil phase can be advantageously selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and the fatty acid triglycerides, in particular the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 carbon atoms.
- the fatty acid triglycerides can be advantageously selected from the group of synthetic, semi-synthetic and natural oils, e.g.
- Cocoglyceride olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil, castor oil, wheat germ oil, grapeseed oil, safflower oil, evening primrose oil, macadamia nut oil and the like.
- the oil phase may further comprise a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils.
- Such silicones or silicone oils may be present as monomers, which are typically characterized by structural elements, as follows:
- Linear silicones having a plurality of siloxyl units which are advantageously used according to the invention are generally characterized by structural elements as follows: wherein the silicon atoms can be substituted with identical or different alkyl radicals and / or aryl radicals, which are here generalized by the radicals Ri - R4 (meaning that the number of different radicals is not necessarily limited to 4), m can thereby Assume values of 2 - 200,000.
- n assume values of 3/2 to 20.
- broken values for n take into account that odd numbers of siloxyl groups may be present in the cycle.
- the aqueous phase of the hydrodispersions according to the invention advantageously contains alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether , Diethy- glycol monomethyl or monoethyl ether and analogous products, furthermore low C-number alcohols, for example ethanol, isopropanol, 1,2-propanediol, glycerol and in particular one or more thickening agents, which or which can be advantageously selected from the group silicon dioxide, aluminum silicates.
- alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glyco
- Preparations according to the invention particularly advantageously comprise one or more hydrocolloids.
- These hydrocolloids can be advantageously selected from the group of gums, polysaccharides, cellulose derivatives, phyllosilicates, polyacrylates and / or other polymers.
- Hydrogel preparations according to the invention contain one or more hydrocolloids. These hydrocolloids can be advantageously selected from the aforementioned group.
- the gums include plant or tree juices that harden in the air and form resins or extracts from aquatic plants.
- gum arabic, locust bean gum, tragacanth, karaya, guar gum, pectin, gellan gum, carrageenan, agar, algins, chondrus, xanthan gum can be selected from this group.
- derivatized gums such as e.g. Hydroxypropyl guar (Jaguar® HP 8).
- polysaccharides and derivatives are e.g. Hyaluronic acid, chitin and chitosan, chondroitin sulphates, starch and starch derivatives.
- cellulose derivatives are e.g. Methylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose.
- phyllosilicates are naturally occurring and synthetic clays such as montmorillonite, bentonite, hectorite, laponite, magnesium aluminum silicates such as VEGEGUM®. These can be used as such or in modified form as, for example, stearylalkonium hectorites. Furthermore, it is also advantageous to use silica gels.
- polyacrylates are e.g. Carbopol types from Goodrich (Carbopol 980, 981, 1382, 5984, 2984, EDT 2001 or Pemulen TR2).
- polyacrylates having the INCI name sodium polyacrylate for example that available from BASF under the trade name Cosmedia SP.
- polymers e.g. Polyacrylamides (Seppigel 305), polyvinyl alcohols, PVP, PVP / VA copolymers, polyglycols.
- compositions which are characterized in that the weight ratios of lipid phase to water phase are selected from the ranges of 99: 1 to 1: 99, preferably 75: 25 to 25: 75, particularly preferably 10: 90 to 20 to 80.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102016221737.2A DE102016221737A1 (en) | 2016-11-07 | 2016-11-07 | Cream for sensitive skin with aloe vera and the lowest possible content of preservatives |
PCT/EP2017/069105 WO2018082820A1 (en) | 2016-11-07 | 2017-07-28 | Cream for sensitive skin, comprising aloe vera and an extremely low content of preservatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3534873A1 true EP3534873A1 (en) | 2019-09-11 |
Family
ID=59416698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17745327.1A Ceased EP3534873A1 (en) | 2016-11-07 | 2017-07-28 | Cream for sensitive skin, comprising aloe vera and an extremely low content of preservatives |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3534873A1 (en) |
DE (1) | DE102016221737A1 (en) |
WO (1) | WO2018082820A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102018212458A1 (en) * | 2018-07-26 | 2020-01-30 | Beiersdorf Ag | Mineral oil and emulsifier free preparation |
DE102018215005A1 (en) * | 2018-09-04 | 2020-03-05 | Beiersdorf Ag | Mattifying hydrodispersion |
DE102018215007A1 (en) * | 2018-09-04 | 2020-03-05 | Beiersdorf Ag | Hydrodispersion with panthenol |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008079898A1 (en) * | 2006-12-20 | 2008-07-03 | Pharmwest, Inc. | Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions |
US8716506B2 (en) * | 2008-10-20 | 2014-05-06 | Chemyunion Quimica Ltda. | Xylitol esters and ethers applied as alternative emulsifiers, solvents, co-emulsifiers and preservative systems for pharmaceutical and cosmetic products |
CA2770283A1 (en) * | 2009-08-06 | 2011-02-10 | Peter Thomas Roth Labs, Llc | Compositions for promoting a healthy appearance of the skin |
CN102755272B (en) * | 2012-07-20 | 2013-09-25 | 澳宝化妆品(惠州)有限公司 | Multi-effect moisturizing and softening composition |
DE102012221227A1 (en) * | 2012-11-20 | 2014-05-22 | Beiersdorf Ag | Sensory attractive hydrodispersion with waxes |
DE102013206718A1 (en) * | 2013-04-15 | 2014-10-16 | Beiersdorf Ag | Emulsifier-free, skin-conditioning cosmetic or dermatological preparation |
DE102014202377A1 (en) * | 2014-02-10 | 2015-08-13 | Beiersdorf Ag | Stable cosmetic hydrodispersion |
DE102014216602A1 (en) * | 2014-08-21 | 2016-02-25 | Beiersdorf Ag | Stable cosmetic preparation |
-
2016
- 2016-11-07 DE DE102016221737.2A patent/DE102016221737A1/en not_active Withdrawn
-
2017
- 2017-07-28 WO PCT/EP2017/069105 patent/WO2018082820A1/en unknown
- 2017-07-28 EP EP17745327.1A patent/EP3534873A1/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO2018082820A1 (en) | 2018-05-11 |
DE102016221737A1 (en) | 2018-05-09 |
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