EP3532497A4 - Modifizierte immunoglobulinbandregionen zur verringerung der hämagglutination - Google Patents
Modifizierte immunoglobulinbandregionen zur verringerung der hämagglutination Download PDFInfo
- Publication number
- EP3532497A4 EP3532497A4 EP17865245.9A EP17865245A EP3532497A4 EP 3532497 A4 EP3532497 A4 EP 3532497A4 EP 17865245 A EP17865245 A EP 17865245A EP 3532497 A4 EP3532497 A4 EP 3532497A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- hemagglutination
- reduce
- hinge regions
- immunoglobulin hinge
- modified immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 230000035931 haemagglutination Effects 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662413018P | 2016-10-26 | 2016-10-26 | |
PCT/US2017/058569 WO2018081448A1 (en) | 2016-10-26 | 2017-10-26 | Modified immunoglobulin hinge regions to reduce hemagglutination |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3532497A1 EP3532497A1 (de) | 2019-09-04 |
EP3532497A4 true EP3532497A4 (de) | 2020-05-13 |
Family
ID=62025462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17865245.9A Pending EP3532497A4 (de) | 2016-10-26 | 2017-10-26 | Modifizierte immunoglobulinbandregionen zur verringerung der hämagglutination |
Country Status (3)
Country | Link |
---|---|
US (2) | US10995152B2 (de) |
EP (1) | EP3532497A4 (de) |
WO (1) | WO2018081448A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018081448A1 (en) * | 2016-10-26 | 2018-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
CA3078253A1 (en) | 2017-10-18 | 2019-04-25 | Forty Seven, Inc. | Anti-cd47 agent-based ovarian cancer therapy |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040175824A1 (en) * | 2001-08-17 | 2004-09-09 | Sun Lee-Hwei K. | Fc fusion proteins of human erythropoietin with high biological activities |
WO2008085878A2 (en) * | 2007-01-03 | 2008-07-17 | Morphotek, Inc. | High affinity antibodies that neutralize staphylcoccus enterotoxin b |
WO2011066501A1 (en) * | 2009-11-30 | 2011-06-03 | Centocor Ortho Biotech Inc. | Antibody fc mutants with ablated effector functions |
WO2012075184A2 (en) * | 2010-12-02 | 2012-06-07 | Neurotech Usa, Inc. | Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof |
WO2012151468A1 (en) * | 2011-05-05 | 2012-11-08 | Wellstat Immunotherapeutics, Llc | Complement factor b analogs and their uses |
WO2013109752A1 (en) * | 2012-01-17 | 2013-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity sirp-alpha reagents |
WO2013181253A1 (en) * | 2012-05-29 | 2013-12-05 | Regeneron Pharmaceuticals, Inc. | Production cell line enhancers |
WO2014031687A1 (en) * | 2012-08-20 | 2014-02-27 | Jensen, Michael | Method and compositions for cellular immunotherapy |
WO2014055515A1 (en) * | 2012-10-02 | 2014-04-10 | Neurophage Pharmaceuticals, Inc. | Use of p3 of bacteriophage fusion proteins as amyloid binding agents |
WO2014094122A1 (en) * | 2012-12-17 | 2014-06-26 | Trillium Therapeutics Inc. | Treatment of cd47+ disease cells with sirp alpha-fc fusions |
WO2014102179A1 (en) * | 2012-12-27 | 2014-07-03 | Bayer Pharma Aktiengesellschaft | Fusion polypeptides and uses thereof |
WO2014123580A1 (en) * | 2013-02-06 | 2014-08-14 | Inhibrx Llc | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
CN104327187A (zh) * | 2014-10-11 | 2015-02-04 | 上海兴迪金生物技术有限公司 | 一种重组人GLP-1-Fc融合蛋白 |
WO2015022420A1 (en) * | 2013-08-16 | 2015-02-19 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
WO2016191305A1 (en) * | 2015-05-22 | 2016-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Btn3a ectodomain proteins and methods of use |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
CN1018817B (zh) | 1988-12-17 | 1992-10-28 | 中国石油化工总公司石油化工科学研究院 | 具有提高酸性的交联粘土的制备 |
WO2000068856A2 (en) | 1999-05-11 | 2000-11-16 | Webvan Group, Inc. | Electronic commerce enabled delivery system and method |
US20090000224A1 (en) | 2002-02-07 | 2009-01-01 | Bay Industries, Inc. | Pultruded door frame |
GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US20060204496A1 (en) * | 2003-11-28 | 2006-09-14 | Tetsuo Kojima | Agonist antibody against heteroreceptor |
JP2005296412A (ja) | 2004-04-13 | 2005-10-27 | Olympus Corp | 内視鏡治療装置 |
US8840933B2 (en) | 2006-05-03 | 2014-09-23 | Warsaw Orthopedic, Inc. | Method of treating neuronal injury by administering magnesium chloride and PEG |
US8330550B2 (en) | 2006-06-23 | 2012-12-11 | Rgb Systems, Inc. | Method and apparatus for automatic compensation of video signal losses from transmission over conductors |
US20110077383A1 (en) | 2007-07-03 | 2011-03-31 | Medimmune, Llc | Hinge domain engineering |
CA2711938C (en) | 2008-01-15 | 2019-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by cd47 |
EP4160212B1 (de) | 2008-01-15 | 2024-04-17 | The Board of Trustees of the Leland Stanford Junior University | Marker für stammzellen der akuten myeloischen leukämie |
GB2459509B (en) | 2008-04-25 | 2011-05-11 | Goodwin Plc | An apparatus for casting and a method of casting |
AR074438A1 (es) | 2008-12-02 | 2011-01-19 | Pf Medicament | Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal |
EP2477648B1 (de) | 2009-09-15 | 2022-07-20 | The Board of Trustees of the Leland Stanford Junior University | Synergistische anti-cd47-therapie für blutkrebs |
JP5837821B2 (ja) | 2009-09-24 | 2015-12-24 | 中外製薬株式会社 | 抗体定常領域改変体 |
JP5628408B2 (ja) | 2010-03-24 | 2014-11-19 | トムソン ライセンシングThomson Licensing | ネットワークのサービス品質を監視する方法及び装置 |
JP2011216948A (ja) | 2010-03-31 | 2011-10-27 | Sony Corp | カメラシステム、映像処理装置及びカメラ装置 |
DK2569013T3 (da) * | 2010-05-14 | 2017-02-13 | Univ Leland Stanford Junior | Humaniserede og kimære monoklonale antistoffer til cd47 |
US9183590B2 (en) | 2010-07-20 | 2015-11-10 | Neopost Technologies | System and method for managing postal accounting data using transient data collectors |
GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
US20140038485A1 (en) | 2011-04-07 | 2014-02-06 | Cargill Incorporated | Bio-based binders including carbohydrates and a pre-reacted product of an alcohol or polyol and a monomeric or polymeric polycarboxylic acid |
CN103649125A (zh) * | 2011-06-22 | 2014-03-19 | 霍夫曼-拉罗奇有限公司 | 利用包含mhc i类的复合物通过循环中的病毒特异性细胞毒性t细胞清除靶细胞 |
PL2812443T3 (pl) | 2012-02-06 | 2020-01-31 | Inhibrx, Inc. | Przeciwciała CD47 i sposoby ich zastosowania |
GB201203071D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
GB201203051D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
DE102012103533A1 (de) | 2012-04-20 | 2013-10-24 | Köra-Packmat Maschinenbau GmbH | Vorrichtung zum Fördern eines Substrats und System zum Bedrucken eines Substrats |
KR101910976B1 (ko) | 2012-07-16 | 2018-10-23 | 삼성전자주식회사 | 그래핀을 이용한 전계효과 트랜지스터 |
DE102012213566A1 (de) | 2012-08-01 | 2014-02-06 | Robert Bosch Gmbh | Verfahren zum Herstellen eines Bondpads zum Thermokompressionsbonden und Bondpad |
EP3721888B1 (de) | 2013-02-05 | 2022-07-20 | The Board of Trustees of the Leland Stanford Junior University | Auf cd47 gerichtete therapien zur behandlung von infektionskrankheiten |
EP2970493B1 (de) * | 2013-03-15 | 2019-04-03 | The Board of Trustees of the Leland Stanford Junior University | Verfahren zur erzielung therapeutisch wirksamer dosierungen von anti-cd47-mitteln |
US9657105B2 (en) * | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
EP2992089B1 (de) | 2013-04-29 | 2021-09-08 | The Board of Trustees of the Leland Stanford Junior University | Verwendung von anti-cd47-mitteln zur immunisierungserhöhung |
WO2014186761A2 (en) | 2013-05-17 | 2014-11-20 | The Board Of Trustes Of The Leland Stanford Junior University | Methods for determining responsiveness to an anti-cd47 agent |
US10329354B2 (en) | 2013-09-18 | 2019-06-25 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of efferocytosis pathways for treatment of atherosclerotic disease |
WO2015105995A2 (en) | 2014-01-08 | 2015-07-16 | The Board Of Trustees Of The Leland Stanford Junior University | Targeted therapy for small cell lung cancer |
ES2822561T3 (es) | 2014-09-15 | 2021-05-04 | Univ Leland Stanford Junior | Direccionamiento a enfermedad por aneurisma modulando las vías de fagocitosis |
EP4019040A1 (de) | 2015-01-21 | 2022-06-29 | The Board of Trustees of the Leland Stanford Junior University | Verwendung von tlr agonisten und anti-cd47 mitteln zur stimulierung der phagozytose von krebszellen |
WO2016138306A1 (en) | 2015-02-27 | 2016-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Combination therapy for treatment of coronary artery disease |
SI3341015T2 (sl) | 2015-08-26 | 2024-03-29 | The Board Of Trustees Of The Leland Stanford, Junior University | Izboljšana deplecija ciljanih celic z blokado CD47 in imunostimulatornim agonistom |
MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
CA3005911A1 (en) | 2015-12-11 | 2017-06-15 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of cancer with dual targeting of cd47 and egfr |
WO2017214096A1 (en) * | 2016-06-07 | 2017-12-14 | Macrogenics, Inc. | Methods for the use of cd32b x cd79b-binding molecules in the treatment of inflammatory diseases and disorders |
WO2018081448A1 (en) * | 2016-10-26 | 2018-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
-
2017
- 2017-10-26 WO PCT/US2017/058569 patent/WO2018081448A1/en unknown
- 2017-10-26 US US16/340,537 patent/US10995152B2/en active Active
- 2017-10-26 EP EP17865245.9A patent/EP3532497A4/de active Pending
-
2021
- 2021-04-06 US US17/223,778 patent/US11760810B2/en active Active
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040175824A1 (en) * | 2001-08-17 | 2004-09-09 | Sun Lee-Hwei K. | Fc fusion proteins of human erythropoietin with high biological activities |
WO2008085878A2 (en) * | 2007-01-03 | 2008-07-17 | Morphotek, Inc. | High affinity antibodies that neutralize staphylcoccus enterotoxin b |
WO2011066501A1 (en) * | 2009-11-30 | 2011-06-03 | Centocor Ortho Biotech Inc. | Antibody fc mutants with ablated effector functions |
WO2012075184A2 (en) * | 2010-12-02 | 2012-06-07 | Neurotech Usa, Inc. | Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof |
WO2012151468A1 (en) * | 2011-05-05 | 2012-11-08 | Wellstat Immunotherapeutics, Llc | Complement factor b analogs and their uses |
WO2013109752A1 (en) * | 2012-01-17 | 2013-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity sirp-alpha reagents |
WO2013181253A1 (en) * | 2012-05-29 | 2013-12-05 | Regeneron Pharmaceuticals, Inc. | Production cell line enhancers |
WO2014031687A1 (en) * | 2012-08-20 | 2014-02-27 | Jensen, Michael | Method and compositions for cellular immunotherapy |
WO2014055515A1 (en) * | 2012-10-02 | 2014-04-10 | Neurophage Pharmaceuticals, Inc. | Use of p3 of bacteriophage fusion proteins as amyloid binding agents |
WO2014094122A1 (en) * | 2012-12-17 | 2014-06-26 | Trillium Therapeutics Inc. | Treatment of cd47+ disease cells with sirp alpha-fc fusions |
WO2014102179A1 (en) * | 2012-12-27 | 2014-07-03 | Bayer Pharma Aktiengesellschaft | Fusion polypeptides and uses thereof |
WO2014123580A1 (en) * | 2013-02-06 | 2014-08-14 | Inhibrx Llc | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
WO2015022420A1 (en) * | 2013-08-16 | 2015-02-19 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
CN104327187A (zh) * | 2014-10-11 | 2015-02-04 | 上海兴迪金生物技术有限公司 | 一种重组人GLP-1-Fc融合蛋白 |
WO2016191305A1 (en) * | 2015-05-22 | 2016-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Btn3a ectodomain proteins and methods of use |
Non-Patent Citations (2)
Title |
---|
HORGAN CAROL ET AL: "Studies on antigen binding by intact and hinge-deleted chimeric antibodies", THE JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 150, no. 12, 15 June 1993 (1993-06-15), pages 5400 - 5407, XP002423580, ISSN: 0022-1767 * |
JIE LIU ET AL: "Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential", PLOS ONE, vol. 10, no. 9, 21 September 2015 (2015-09-21), pages 1 - 23, XP055223677, DOI: 10.1371/journal.pone.0137345 * |
Also Published As
Publication number | Publication date |
---|---|
US20200048369A1 (en) | 2020-02-13 |
EP3532497A1 (de) | 2019-09-04 |
US20210253740A1 (en) | 2021-08-19 |
WO2018081448A1 (en) | 2018-05-03 |
WO2018081448A8 (en) | 2024-01-04 |
US10995152B2 (en) | 2021-05-04 |
US11760810B2 (en) | 2023-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3423089A4 (de) | Anti-tigit-antikörper | |
EP3498840A4 (de) | Anti-lag-3-antikörper | |
EP3411412A4 (de) | Fabs-in-tandem-immunglobulin und verwendungen davon | |
EP3481869A4 (de) | Anti-cd73-antikörper | |
EP3387442A4 (de) | Humanisierte anti-cd73-antikörper | |
EP3449940A4 (de) | Antikörperhaltiges präparat | |
EP3204422A4 (de) | Humanisierte anti-ox40-antikörper und verwendungen davon | |
EP3354729A4 (de) | Anti-garp-antikörper | |
EP3363816A4 (de) | Anti-ox40-antikörper und verwendungen davon | |
EP3417133A4 (de) | Scharnier | |
EP3341485A4 (de) | Erhöhte produktion von immunglobulinen | |
EP3526431A4 (de) | Scharnieranordnung | |
EP3532092A4 (de) | Immunglobuline und verwendungen davon | |
EP3380524A4 (de) | Humanisierte anti-cll-1-antikörper | |
EP3252074A4 (de) | Anti-alk2-antikörper | |
EP3492591A4 (de) | Anti-b7-h4-antikörper | |
EP3101131A4 (de) | Humanisierte anti-transthyretin-antikörper | |
EP3411476A4 (de) | Erhöhte produktion von immunglobulinen | |
EP3437776A4 (de) | Verbindungsstruktur | |
EP3507177A4 (de) | Motorroller mit klapperschutz | |
EP3526247A4 (de) | Anti-il1-rap-antikörper | |
EP3457004A4 (de) | Dichtungsstruktur | |
EP3381941A4 (de) | Anti-epha4-antikörper | |
EP3197915A4 (de) | Humanisierte anti-hepcidin-antikörper und verwendungen davon | |
EP3437786A4 (de) | Verbindungsstruktur |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20190524 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20200417 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 38/19 20060101ALI20200408BHEP Ipc: C07K 16/18 20060101AFI20200408BHEP Ipc: C12N 5/10 20060101ALI20200408BHEP Ipc: C07K 16/28 20060101ALI20200408BHEP Ipc: C12N 15/85 20060101ALI20200408BHEP Ipc: G01N 33/53 20060101ALI20200408BHEP Ipc: C07K 14/705 20060101ALI20200408BHEP Ipc: C07K 16/46 20060101ALI20200408BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20220317 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20230711 |
|
GRAJ | Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted |
Free format text: ORIGINAL CODE: EPIDOSDIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
INTC | Intention to grant announced (deleted) | ||
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20240220 |