EP3526039A1 - Matériau d'emballage stérilisable - Google Patents

Matériau d'emballage stérilisable

Info

Publication number
EP3526039A1
EP3526039A1 EP17781515.6A EP17781515A EP3526039A1 EP 3526039 A1 EP3526039 A1 EP 3526039A1 EP 17781515 A EP17781515 A EP 17781515A EP 3526039 A1 EP3526039 A1 EP 3526039A1
Authority
EP
European Patent Office
Prior art keywords
packaging material
further preferred
material according
ppm
sterilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17781515.6A
Other languages
German (de)
English (en)
Inventor
Sarah Van Mierloo
Bart VAN DEN ESSCHERT
Paul Davidson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SABIC Global Technologies BV
Original Assignee
SABIC Global Technologies BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SABIC Global Technologies BV filed Critical SABIC Global Technologies BV
Publication of EP3526039A1 publication Critical patent/EP3526039A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
    • C08K5/098—Metal salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C08J2323/08—Copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/10—Homopolymers or copolymers of propene
    • C08J2323/14—Copolymers of propene

Definitions

  • the invention relates to a serialized packaging material and comprising a polyethylene and an a-tocopherol.
  • Suitable stabilisers known in the art are for example synthetic (poly)phenolic compounds such as tetrakis[methylene-3-(3',5')-di-t-butyl-4-hydroxyphenyl)propionate] methane;
  • octadecyl 3,5-di-t-butyl-4-hydroxyhydrocinnamate 1 ,1 ,3-tris(2-methyl-4-hydroxy-5-t- butylphenyl)butane; 1 ,3,5-trimethyl-2,4,6-tris(3,5-di-t-butyl-4-hydroxybenzyl)benzene, bis- [3,3-bis-(4'-hydroxy-3'-t-butylphenyl butanoic acid]-glycol ester; tris(3,5-di-t-butyl-4-hydroxy benzyl)isocyanurate; 1 ,3,5-tris(4-t-butyl-2,6-dimethyl-3-hydroxy-benzyl)isocyanurate; 5-di-t- butyl-4-hydroxy hydrocinnamic acid triester with 1 ,3,5-tris(2-hydroxyethyl)-s-triazine- 2,4,6(1 H, 3
  • stabilizers selected from the group consisting of organic phosphites or phosphonites.
  • organic phosphites or phosphonites For example tris (2,4-di-t-butylphenyl) phosphite.
  • the stabilized polyolefins and/or the packaging material may be processed via for example injection moulding, blow moulding, extrusion moulding, compression moulding or thin-walled injection moulding techniques.
  • the obtained products may be applied in a huge amount of applications for example in food packaging applications, biomedical applications, health care applications or pharmaceutical applications.
  • sterilization is required or desired. Sterilization can thereby be achieved for example through a heat treatment and/or by irradiation, especially for example by irradiation with a-radiation (alpha radiation) and/or ⁇ -radiation (beta radiation) and/or v- radiation (gamma radiation).
  • irradiation especially for example by irradiation with a-radiation (alpha radiation) and/or ⁇ -radiation (beta radiation) and/or v- radiation (gamma radiation).
  • Sterilization may thereby possibly lead to degradation, especially for example to a degradation of some stabilizers, which in turn may influence product properties, especially mechanical properties. Indeed, degradation products obtained after sterilization may have an influence on mechanical properties.
  • degradation products may thereby be regulated by governments because they are suffering from serious limitations. Synthetic antioxidants and/or related degradation products can especially diffuse into the surrounding medium. This can in turn lead to contamination of food and/or other products with potentially toxic or at least concerning substances or byproducts as well as related degradation products. This problem may arise simply because some antioxidants or degradation products or by-products are toxic above a certain level of concentration or are just perceived as concerning. Sterilization may thereby furthermore increase the likelihood of leakage of stabilizers, by-products and/or degradation products.
  • A a copolymer of ethylene and at least one a-olefin and/or a copolymer of propylene with an a-olefin and/or mixtures of two or more thereof, and - B. between 50 and 200 ppm by weight of a-tocopherol relative to the component
  • This may especially for example allow to reduce the leak of phosphate(s) and/or di-tert- butyl-phenol and/or 7,9-di-tert-butyl-1 -oxaspiro[4.5]deca-6,9-diene-2,8-dione from sterilized, especially irradiated material. This may for example improve organoleptic properties.
  • the risk related to and/or the amount of compound(s) possibly migrating out of the packaging material may thereby be reduced. Furthermore the sterilizable packaging material may show improved processing stability.
  • Component A may be for example a polyethylene, especially for example a copolymer of ethylene with at least one a-olefin, preferably a linear low density polyethylene (LLDPE), a high density polyethylene (HDPE), a low density polyethylene (LDPE) and/or mixtures of two or more thereof.
  • LLDPE linear low density polyethylene
  • HDPE high density polyethylene
  • LDPE low density polyethylene
  • a copolymer of ethylene with at least one ⁇ -olefin may thereby preferably be a copolymer comprising ethylene and at least one ⁇ -olefin or a copolymer of ethylene and only one a-olefin.
  • the packaging material according to the invention may comprise component A in an amount of for example between 50 and 100 wt. % preferably between 60 and > 99.5 wt. %, further preferred between 70 and >99.7 wt. %, further preferred between 80 and > 99.8 wt. %, further preferred between 90 and >99.9 wt. % based on the total weight of the material.
  • the production processes of LDPE, HDPE and LLDPE are summarised in Handbook of Polyethylene by Andrew Peacock (2000; Dekker; ISBN 0824795466), especially for example at pages 43-66.
  • the catalysts used can include for example Ziegler Natta catalysts, Phillips catalysts and single site catalysts.
  • the latter class is a family of different classes of compounds, which comprises metallocene catalysts.
  • a polymer prepared using a Ziegler-Natta catalyst is obtained for example via the interaction of an organometallic compound or hydride of a Group l-lll metal with a derivative of a Group I - I 11 transition metal.
  • An example of a (modified) Ziegler-Natta catalyst may thereby be for example a catalyst based on titanium tetra chloride and the organometallic compound
  • linear low density polyethylene as used herein is meant an ethylene-alpha olefin copolymer comprising ethylene and a C3-C10 alpha-olefin comonomer.
  • Suitable alpha- olefin comonomers include 1 -butene, 1 -hexene, 4-methyl pentene and 1 -octene.
  • the preferred comonomer may be 1 -hexene or 1 -butene.
  • the alpha-olefin comonomer is present in an amount of for example from about 2.5 to 30 percent by weight of the ethylene-alpha olefin copolymer, preferably from 5 to about 20 percent by weight of the ethylene-alpha olefin copolymer, more preferably an amount of from about 7 to about 15 percent by weight of the ethylene-alpha olefin copolymer.
  • Linear low density polyethylene used herein may thereby for example comprise between 3 and 200 CH 3 per 1000 carbon atoms, preferably between 4 and 100 CH 3 per 1000 carbon atoms, preferably between 5 and 40 CH 3 per 1000 carbon atoms, preferably between 10 and 30 CH 3 per 1000 carbon atoms, further prefer between 15 and 25 CH 3 per 1000 carbon atoms, as determined by NMR.
  • the technologies suitable for the LLDPE manufacture include but are not limited to gas- phase fluidized-bed polymerization, polymerization in solution, and slurry polymerization.
  • the LLDPE has been obtained by gas phase polymerization in the presence of a Ziegler-Natta catalyst.
  • the LLDPE may be obtained by gas phase polymerization in the presence of a metallocene catalyst.
  • a polyethylene and/or copolymer of ethylene and at least one a-olefin may for example have a density as determined according to ISO 1 183-1 (2012), method A of ⁇ 850 kg/m 3 and ⁇ 950 kg/m 3 , preferably ⁇ 910 kg/m 3 and ⁇ 940 kg/m 3 , further preferred between 913 kg/m 3 and 923 kg/m 3 . This may lead to mechanical properties suitable for the use for film applications.
  • a polyethylene and/or a copolymer of ethylene and at least one a-olefin may for example have an MFI represented by the corresponding melt mass flow rate (MFR) as measured according to ISO 1 131 -1 (201 1 ) at 190°C and at a load of 2.16 kg of between 0.1 dg/min and 10 dg/min, preferably between 0.5 dg/min and 6 dg/min, further preferred between 0.5 dg/min and 4 dg/min, even further preferred between >0.5 dg/min and 3.5 dg/min or between >0.5 dg/min and ⁇ 2 dg/min. This may lead to a processability suitable for the use for film applications.
  • MFR melt mass flow rate
  • Component B may be ⁇ -tocopherol.
  • Component B may be added for example as a liquid and/or using a master batch comprising between 0.5 w.-% and 5 w.-%, preferably between 1 and 5 w.-% of ⁇ -tocopherol and/or between 5 and 40 w.-%, preferably between 5 and 15 w.-%, of a organometallic stearate as component C and the rest of the master batch up to 100 w.-% being a further polyethylene as component D, preferably low density
  • the ⁇ -tocopherol may be preferably synthetic ⁇ -tocopherol. This allows a good control over wat is actually added.
  • a suitable example of ⁇ -tocopherol and/or synthetic ⁇ -tocopherol according to the invention may be Irganox E 201 (supplied by BASF) which is a racemic mixture of equal amounts of all eight possible stereoisomers of ⁇ -tocopherol (RRR, SSS, RRS, RSR, SSR, SRS, SRR, RSS) and is referred to as D,L-a-tocopherol or all-rac-alpha-tocopherol.
  • a-tocopherol may for example allow to achieve efficient stabilization with relatively low loadings of a-tocopherol.
  • the sterilizable packaging material may preferably not comprise other tocopherols and/or no tocotrienol and/or preferably comprise no natural vitamin E and/or no other antioxidant and/or no other compound comprising at least one phenolic motif. This may allow an efficient stabilization of the packaging material, while reducing the risk associated with and/or the amount of compounds that may migrate out of the packaging material. This may thus reduce possible health hazards.
  • the amount of component B ranges between 25 ppm and 300 ppm by weight, preferably between 50 ppm and 200 ppm by weight, further preferred between > 50 ppm and ⁇ 180 ppm by weight, further preferred between > 75 ppm and ⁇ 175 ppm, further preferred between > 90 ppm and 170 or ⁇ 170 ppm relative to the component A.
  • the copolymer of ethylene and at least one a-olefin and/or a copolymer of propylene with an ⁇ -olefin and/or mixtures of two or more thereof of the packaging material according to the invention is/are produced using one Ziegler-Natta catalyst.
  • the sterilizable packaging material according to the invention may also comprise component C, which may be at least one acid scavenger , preferably at least one organometallic stearate such as for example magnesium stearate, aluminum stearate, sodium stearate and calcium stearate and/or at least one inorganic hydrotalcites, such as for example DHT4A , preferably calcium stearate. This may further contribute to improve processability.
  • component C may be at least one acid scavenger , preferably at least one organometallic stearate such as for example magnesium stearate, aluminum stearate, sodium stearate and calcium stearate and/or at least one inorganic hydrotalcites, such as for example DHT4A , preferably calcium stearate. This may further contribute to improve processability.
  • the amount of optional component C may range between 100 ppm and 1000 ppm by weight, more preferably between 200 ppm and 800 ppm by weight, further preferred between 400 ppm and 600 ppm by weight, relative to the component A.
  • the weight ratio B:C may range for example between 0.05:1 and 0.6:1 , preferably 0.07:1 to 0.5:1 , further preferred between 0.1 :1 and 0.4:1 .
  • the sterilizable packaging material according to the invention may also comprise component D, which may be at least one further polyethylene, preferably a low density polyethylene or a polypropylene.
  • the amount of compound D may be between 0 and 10 000 ppm, preferably between 2000 and 7000 ppm.
  • the further polyethylene may be different from component A and/or may especially be for example LDPE.
  • the packaging material according to the invention may thereby for example have an extractable amount (in mg of compounds per kg of packaging material) measured by PTV- GC-MS in a NIAS study (as explained below) of 2,6-di-tert-butylbenzoquinone preferably below 0.8 mg/kg, preferably below 0.5 mg/kg, and/or of 7,9-di-tert-butyl-1 - oxaspiro[4.5]deca-6,9-diene-2,8-dione below 0.4 mg/kg, preferably below 0.2 mg/kg, and/or methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate below 0.5 mg/kg and/or of 2,4 di-tert- butyl-phenol below 10 mg/kg, preferably below 1 mg/kg, further preferred below 0.5 mg/kg, and/or an extractable amount measured by LC-MS in a NIAS study (as explained below) of phosphate below 5 mg/
  • TD-GC-MS which couples thermal desorption (TD), gas chromatography (GC) and mass spectroscopy (MS).
  • a thermal desorption unit Markes TD100 was thereby used together with a GC Agilent 7890A and Agilent 5975C Mass detector, further using ChemStation E.02.02.1431 software and a column Agilent HP-ULTRA 2 50m * 0.320mm, 0.52 ⁇ film.
  • the following temperature program was used: initial temperature of 40 °C, hold for 2 min, ramp 3 ⁇ C/min until 92 ⁇ C, ramp 5°C/min until 160 ⁇ C, ramp 10°C/min until 280°C, hold for 10 min. Detection range was 29 - 450 AMU. Thermal desorption was performed for 40 minutes at 1 10 ° C. The sample was weighed in empty thermal desorption tubes. Calculations were performed against an external standard of toluene. Semi-volatiles were analyzed by PTV-GC-MS, which couples programmed temperature vaporization (PTV), GC and MS.
  • PTV programmed temperature vaporization
  • a GC Agilent 6890N was thereby used with a Agilent 5973 mass detector and an autosampler Agilent G2614, whereby further using ChemStation E.02.02.1431 software and an Agilent HP5MS 60M * 0.250mm Column, 1.0 ⁇ film .20 ⁇ were thereby injected at 50 ° C.
  • the following temperature program was used: initial temperature of 70 °C, hold for 0.5 min, ramp 10 ⁇ C/min until 300 ⁇ C, hold for 45 min. Detection range in MS was 30 - 500 AMU.
  • Non-volatiles were analyzed by LC-MS, which couples liquid chromatography (LC) and MS.
  • LC-MS liquid chromatography
  • MS MS
  • a liquid chromatography unit LC Waters Acquity H Class was thereby used together with a Waters SQ Detector 2 detector and MassLynx V4.1 software as well as
  • the mobile phase comprised 0.1 % formic acid in water (A), methanol (B) and isopropanol (C) with a gradient from 20% A, 70% B and 10% C to 90% B and 10% C within 6 min and a hold for 1 min.
  • the flow was set to 0.4 ml/min.
  • the MS-screening was performed for the range of m/z 100-2000 with atmospheric pressure chemical ionization (APCI) in positive/negative mode.
  • APCI atmospheric pressure chemical ionization
  • the packaging material according to the invention may thereby have an amount of compound migrating based on a migration study applying the modelling software Migratest EXP2013 (Fabes) and/or a complete migration calculation (as described above) of ⁇ 1 mg/kg (in mg of compounds per kg of food).
  • a sterilized packaging material according to the invention may preferably for example comprise and/or consist of:
  • A a copolymer of ethylene and at least one a-olefin and/or a copolymer of propylene with an a-olefin and/or mixtures of two or more thereof, and
  • an acid scavenger for example a organometallic stearate, preferably calcium stearate, relative to the component A,
  • the sterilizable packaging material consists of the components listed above may thereby preferably mean that no other antioxidant and/or no other acid scavenger and/or no other acid scavenger and/or no other organometallic stearate or hydrotalcite and/or no other compound/component is present.
  • the sterilizable packaging material according to the invention may be used in the production of specific packaging articles. Examples of preferred articles are films and/or pouches, especially for applications such as food and/or beverage packaging applications, for health care applications and/or pharmaceutical applications and/or medical or biomedical applications, whereby the packaging material according to the invention is sterilized.
  • the present invention also concerns the use of a sterilizable packaging material according to the invention may be used in the production of specific articles.
  • a sterilizable packaging material according to the invention may be used in the production of specific articles.
  • preferred articles are films and/or pouches, especially for applications such as food and/or beverage packaging applications, for health care applications and/or
  • the sterilizable packaging material according to the invention may for example be part of a multi-layer structure, especially for example a multi-layer structure that comprises at least one aluminum layer, preferably at least one aluminum intermediate layer, and/or at least one PET layer, preferably at least one PET outer layer, and/or a at least one inner layer of the packaging material according to the invention.
  • the packaging material according to the invention may especially be used in so called blow-fill-seal applications and processes.
  • Blow-fill-seal applications and processes may thereby be applications and processes, used for example in the pharmaceutical industry, where a container is formed, filled, preferably for example with a liquid, and sealed in one process, which preferably does require a little human interaction as possible and/or is carried out inside a machine and/or in a sterile enclosed environment. This may improve antiseptic processing.
  • the packaging material according to the invention may for example be part of a multi-layer structure, especially for example a multi-layer structure that comprises at least one PET layer, preferably at least one PET outer layer, and/or a at least one inner layer of the packaging material according to the invention.
  • Such a multilayer structure may be used for example as lid film for trays, especially for example for food trays.
  • Sterilizable in the sense present invention may thereby especially mean that it can for example be subjected to sterilisation by a ⁇ -radiation (gamma radiation) of for example 20 kilogray, preferably 25 kilogray, further preferred 35 kilogray (kGy).
  • Sterilizable may however also be used herein as synonymous of and interchangeably with (actually) sterilized, especially for example by a ⁇ -radiation (gamma radiation) of for example 20 kilogray, preferably 25 kilogray, further preferred 35 kilogray (kGy).
  • the packaging material and/or sterilisable packaging material according to the invention may thus preferably be a sterilized packaging material.
  • Each of the and/or all of the tensile modulus MD 1 % secant ( in MPa) measured according to ASTM D882 and/or the impact resistance F max (N) measured according to ISO 7765-2 and/or the haze (%) measured according to ASTM D1003 of the sterilizable packaging material according to the invention does not vary by more than 50 %, preferably more than 25 %, further preferred by more than 20 %, further preferred by more than 10 %, further preferred by more than 5 %, when blown films with film thickness 25 and/or 125 micron are subjected to sterilization by a ⁇ -radiation (gamma radiation) with a dose of 20 kilogray, preferably 25 kilogray, further preferred
  • the sterilized packaging material according to the invention may be so, that the Mw/Mn of the linear low density polyethylene is between 4 and 12, preferably between 4.5 and 1 1 , further preferred between 4.7 and 10, further preferred between 5 and 8, further preferred between > 5 and ⁇ 7, further preferred between > 5.5 and ⁇ 6.5 and/or the Mz/Mw of the linear low density polyethylene between 4 and 12, preferably between 4.5 and 1 1 , further preferred between 4.7 and 10, further preferred between 5 and 8, further preferred between > 5 and ⁇ 7, further preferred between > 5.8 and ⁇ 6.8.
  • the sterilized packaging material according to the invention may be so, that the linear low density polyethylene has a density of ⁇ 850 kg/m 3 and ⁇ 950 kg/m 3 , preferably ⁇ 910 kg/m 3 and ⁇ 940 kg/m 3 , further preferred between 913 kg/m 3 and 923 kg/m 3 , further preferred between > 915 kg/m 3 and ⁇ 921 and/or a melt mass flow rate (MFR) as measured according to ISO 1 131 -1 (201 1 ) at 190°C and at a load of 2.16 kg of between 0.1 dg/min and 12 dg/min, preferably between 1 dg/min and 1 1 dg/min, further preferred between 3 dg/min and 10 dg/min, even further preferred 4 dg/min and 9 dg/min, even further preferred > 4 dg/min and ⁇ 9 dg/min.
  • MFR melt mass flow rate
  • the sterilized packaging material according to the invention may be so, that the packaging material does not comprise other tocopherols and/or comprises no tocotrienol and/or no natural vitamin E and/or no other antioxidant and/or no other compound comprising at least one phenolic motif and/or wherein the packaging material comprises only a-tocopherol as antioxidant.
  • the invention also concerns a sterilized packaging
  • the invention further concerns a sterilized packaging, whereby
  • the multi-layer structure is a lid or pouch for food and/or beverage packaging, especially for food trays, and/or as lid or pouch for a packaging for a medicine, an implant, a patch or another item for medical or biomedical use.
  • the polymer was packaged in transparent bags without particular handling.
  • Irradiation may take several hours.
  • the gamma rays may result from the decay of the radioactive isotope Cobalt-60 ( 60 Co). They have a high penetration depth and can penetrate complete pallets or lots.
  • a conveyor system transports around the source rack which houses the radiation sources. Controls ensure that the total gamma irradiation dose that has been fixed for each product is adhered to.
  • Sterilized packaging material according to the invention may (after sterilization) thereby displayed an extractable amount (in mg of compounds per kg of packaging material) measured by PTV-GC-MS in a NIAS study (as explained herein) of 2,6-di-tert- butylbenzoquinone preferably below 0.8 mg/kg, preferably below 0.5 mg/kg, and/or of 7,9- di-tert-butyl-1 -oxaspiro[4.5]deca-6,9-diene-2,8-dione below 0.4 mg/kg, preferably below 0.2 mg/kg, and/or methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate below 0.5 mg/kg and/or of 2,4 di-tert-butyl-phenol below 10 mg/kg, preferably below 1 mg/kg, further preferred below 0.5 mg/kg, and/or an extractable amount measured by LC-MS in a NIAS study (as explained herein) of phosphat

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Wrappers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

L'invention concerne un matériau d'emballage stérilisé comprenant : A. un copolymère d'éthylène et d'au moins une α-oléfine et/ou un copolymère de propylène avec une α-oléfine et/ou des mélanges d'au moins deux de ces éléments ; et B. entre 50 et 200 ppm en poids d'α-tocophérol par rapport au composant A.
EP17781515.6A 2016-10-14 2017-10-15 Matériau d'emballage stérilisable Withdrawn EP3526039A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16193912 2016-10-14
PCT/EP2017/076264 WO2018069540A1 (fr) 2016-10-14 2017-10-15 Matériau d'emballage stérilisable

Publications (1)

Publication Number Publication Date
EP3526039A1 true EP3526039A1 (fr) 2019-08-21

Family

ID=57153331

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17781515.6A Withdrawn EP3526039A1 (fr) 2016-10-14 2017-10-15 Matériau d'emballage stérilisable

Country Status (3)

Country Link
EP (1) EP3526039A1 (fr)
CN (1) CN110049873A (fr)
WO (1) WO2018069540A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2146034A1 (fr) * 1994-05-12 1995-11-13 Kenneth W. Willcox Stabilisation de polymeres
EP0878502A2 (fr) * 1997-05-05 1998-11-18 Ciba SC Holding AG Formulations de Vitamine E pour la stabilisastion de matériaux polymères organiques
EP2164892A1 (fr) * 2007-07-10 2010-03-24 Basf Se Compositions de stabilisateurs
BR112015008372A2 (pt) * 2012-10-16 2017-07-04 Saudi Basic Ind Corp uso de uma composição de lldpe em aplicações de cuidados de saúde
US20170029597A1 (en) * 2013-11-29 2017-02-02 Saudi Basic Industries Corporation Stabilised polyolefin composition
WO2017114782A1 (fr) * 2015-12-29 2017-07-06 Sabic Global Technologies B.V. Composition de polyoléfine stabilisée

Also Published As

Publication number Publication date
WO2018069540A1 (fr) 2018-04-19
CN110049873A (zh) 2019-07-23

Similar Documents

Publication Publication Date Title
EP0759873B1 (fr) PROCEDE DE STERILISATION PAR RAYONNEMENT $g(g) ET PAR UTILISATION D'UN ABSORBEUR D'OXYGENE, RESERVOIR ET ARTICLE MEDICAL STERILISES AU MOYEN DUDIT PROCEDE
US9561306B2 (en) Methods for making oxidation resistant polymeric material
US7906064B2 (en) Methods for making oxidation resistant polymeric material
CA2679274C (fr) Reticulation de polymeres contenant des antioxydants
US9731047B2 (en) High temperature melting
Gijsman et al. Hindered amine light stabilizers: an alternative for radiation cross-linked UHMwPE implants
NO176803B (no) Strålingssteriliserbar propylenpolymerblanding og anvendelse av denne
EP2906628B1 (fr) Compositions de polyéthylène comprenant du polypropylène
CA2927056A1 (fr) Reticulation de peroxyde et fusion a haute temperature
WO2018069540A1 (fr) Matériau d'emballage stérilisable
WO2016200335A1 (fr) Article moulé à partir d'une composition de polypropylène
EP3526040A1 (fr) Matériau d'emballage
WO2017114782A1 (fr) Composition de polyoléfine stabilisée
Tone et al. Study on the Properties of PLA-and PP-Based Films for Food Applications Incorporating Orange Peel Extract from Agricultural by-Products
AU2012254872B2 (en) Methods for making oxidation resistant polymeric material
Richaud Stabilization of irradiated polyethylene by introduction of antioxidants (vitamin E)
AU2013200723B2 (en) Cross-linking of antioxidant-containing polymers

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20190507

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20191204