EP3473284B1 - Elastisches und gleitendes ventilgelenk, geeignet zum arbeiten in vorgefüllten spritzen und diese spritzen - Google Patents

Elastisches und gleitendes ventilgelenk, geeignet zum arbeiten in vorgefüllten spritzen und diese spritzen

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Publication number
EP3473284B1
EP3473284B1 EP18000270.1A EP18000270A EP3473284B1 EP 3473284 B1 EP3473284 B1 EP 3473284B1 EP 18000270 A EP18000270 A EP 18000270A EP 3473284 B1 EP3473284 B1 EP 3473284B1
Authority
EP
European Patent Office
Prior art keywords
discoid
elastic
valvular
syringe
plug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18000270.1A
Other languages
English (en)
French (fr)
Other versions
EP3473284C0 (de
EP3473284A1 (de
Inventor
Jaime Luis Szapiro
Saúl Moreno Bonino
Germán Andrés Szapiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MORENO BONINO, SAUL
Szapiro German Andres
Szapiro Jaime Luis
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP3473284A1 publication Critical patent/EP3473284A1/de
Application granted granted Critical
Publication of EP3473284C0 publication Critical patent/EP3473284C0/de
Publication of EP3473284B1 publication Critical patent/EP3473284B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3106—Plugs for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31571—Means preventing accidental administration

Definitions

  • the present invention makes reference to the field of syringes to apply injections, preferably to those pre-filled and disposable syringes, and even more particularly to an elastic and sliding valvular joint for pre-filled disposable syringes to maintain the contents therein completely isolated and sterile, preventing them to reach the needle before the injection.
  • an internal chamber of variable volume is defined.
  • This chamber constitutes the temporary location for the product to be injected.
  • Said chamber is determined by the cylindrical wall of the main body, the cited front neck, where the needle couples, and the active head of the plunger manually movable that is exactly supported by the internal face of said cylindrical wall of the main body.
  • pre-filled double-chamber syringes which are used for those cases where two different liquid products are stored, or when one liquid product and another powdered product must be kept completely isolated and separated one from the other until the moment of injection, where they are previously mixed.
  • said internal valvular means which constitute the partition that separates both chambers, are designed for the user to mix the products before the injection without being contaminated by the outer environment. That is to say, it maintains the isolation from origin. It is then that the protective sheath can be removed from the needle and, the resulting mix can be moved to the needle, initiating the injection process.
  • the central tube of second engaging means is in fact provided of the piston of the syringe.
  • the valvular joint is an entity separate from and freely sliding with respect to the piston of the piston of the prefilled syringe.
  • Patent application AR 100575 A3 concerns a valvular resource of the type comprising two disc elements of co-operative action, which are placed inside the main body of the syringe with its perimeter edges resting on the cylindrical surface of the syringe.
  • One of them is an elastic and sliding disc plug, while the other is the receiver disc seat on which the plug acts, where the perimeter edges of the bases of both disc elements determine cords that are thicker and less elastic than the rest of the body of each valve element.
  • the elastic sliding disc plug comprises a closed flat base which, from its internal face, projects a hollow sealing cylinder whose distal base is open, while its thicker perimetral cord is affected by peripheral lateral grooves constituting the respective product passage ducts during its operation. On the thickest perimetral cord, two or more peripheral lateral grooves located equidistant from each other are defined, which are of the same height as the thickness of the same.
  • This application describes a valve resource in an attempt to achieve a valve assembly independent of a single material, such as santoprene, and of an exclusive method of manufacture. It is also intended to eliminate the perforations in the flat body of the disc comprising the plug by two perimeter grooves. This resource weakens the perimeter edge of the disc which must be thicker and less elastic than the rest of the body and therefore affects its functioning. Likewise, the passage of product through the aforementioned grooves is not substantially improved. Specifically, versatility of materials and method of manufacture was sought and the flow rate improved through the perimeter grooves, but the perimeter adjustment cord of the disk against the syringe wall was weakened.
  • the main object of this invention is a pre-filled syringewith a single-chamber type that stores the product to be injected, or in those of two independent internal chambers that contain the corresponding isolated products to be mixed before the injection, and which contains a sliding and elastic valvular joint suitable to work in the interior of the cited pre-filled syringe wherein this valvular joint acts as a temporary closure that prevents an internal chamber from communicating with the communication tube towards the injection needle or between both internal chambers, containing-said valvular joint two cooperative discoid elements arranged inside the main body of the syringe, with its perimeter edge supported by its cylindrical surface, wherein one of said elements is an elastic discoid plug, while the other consists of a sliding receiving discoid seat, on which said plug acts through a cylindrical central passage tube wherein the perimeter edge of the discoid seat consists of a cordon, which is thicker and less elastic than the rest of the body of each discoid seat wherein the elastic
  • the closing hollow cylinder that is formed from the elastic base of the elastic discoid plug of the elastic valvular joint has a circular section, where the external diameter is slightly bigger than the diameter of the central passage tube of the sliding receiving discoid seat, offering a calibrated fit.
  • the closing hollow cylinder that is formed from the elastic base of the valvular plug of the elastic valvular joint includes a plurality of external annular flanges that are temporarily supported by the cylindrical surface defined by the central passage tube from the sliding receiving discoid seat, offering a calibrated fit.
  • the central passage tube of the sliding receiving discoid seat of the elastic valvular joint includes in its opening at least two superficial adjacent cavities facing each other, which communicate with the interior of the central passage tube of the sliding receiving discoid seat.
  • the cooperative discoid elements of the elastic valvular joint are combined with an upper closure plug (tip-cap) that closes the communication tube towards the injection needle, which is not pre-installed in its position, act as a temporary closure for pre-filled syringes of two internal coaxial chambers, where said cooperative discoid elements are arranged as a separating partition between said chambers.
  • tip-cap an upper closure plug
  • the cooperative discoid elements of the elastic valvular joint which are arranged as a temporary closure that prevents the internal communication of the main body of the syringe with the communication tube towards the injection needle, act as a temporary closure for pre-filled syringes of a single chamber.
  • the present invention refers to a pre-filled syringe that consists of an elastic valvular joint according to any of the above claims, forming two chambers, where each one of them holds a different product being at least one of them liquid; and where both products after being mixed result in a solution to be injected, and the elastic discoid plug of the elastic valvular joint is opposite to the head of the plunger.
  • the pre-filled syringes of this invention contains a valvular joint which belongs to the group of those adaptable to any type of body of the conventional syringe, whether single-chamber or double-chamber.
  • This valvular joint takes into account the condition of adapting to any type of conventional syringe, the non-alteration of automatized processes for getting the products inside the syringe, especially for the cases of double-chamber pre-filled syringes, and also the lack of special and/or complicated tasks demanded to the user when mixing and later injecting.
  • the elastic and sliding valvular joint (1) for syringes (2) previously filled and referred to in this invention consists of two mutually cooperative elements represented by (3 and 4).
  • This elastic discoid plug (3) stands out especially since a closing hollow cylinder (6), which is coaxial with the mentioned elastic discoid base, is formed from its internal face and, its distant face is totally open.
  • the elastic discoid plug (3) and the receiving discoid seat (4) of the valvular joint (1) are cooperative elements because they must necessarily act together for the valvular opening and closing actions.
  • said elements (3 and 4) must be overlapped and aligned between them inside the syringe; so that the mentioned closing cylinder (6) perfectly fits the interior of the central passage tube (7) generating the hermetic closure that prevents the products contained inside the syringe (2) previously filled from moving through said tube.
  • said bigger diameter of the closing hollow cylinder (6) can be obtained through a plurality of external annular flanges (11), which are temporary supported by the cylindrical surface that defines the central passage tube (7) of the sliding receiving discoid seat (4).
  • the syringe (2) includes its corresponding needle (18) of injection, which is covered by a protective sheath (19), which usually accompanies the commercial product in its container.
  • the user moves the head (20) of the plunger (21) in the direction (F) opposite to the direction of the injection, generating a depression in the lower chamber (13), which consequently produces the movement of the elastic discoid plug (3) liberating the central passage tube (7) of the receiving discoid seat (4), and hence liberating the communication between both upper and lower chambers (12 and 13).
  • the product (14) flows through the central tube (7) of the receiving discoid seat (4).
  • Figure 13 shows the arrangement of the referred elements (3 and 4) and the obtaining of the solution (22) to be injected by mixing the referred products (14 and 15), which is completely located in the upper distant chamber (12) and which is always duly isolated from the exterior by a closure plug (16).
  • Figures 11, 12 and 13 show that as a consequence of the communication set through the central passage tube (7), when the user moves the head (20) of the plunger (21) in the direction (FI) of the injection, the mentioned solution (22) moves from the lower or closer chamber (13) towards the upper or distant chamber (13) in a way that the solution is possible to be injected (22). Said solution was obtained in the same was as any other prefilled syringe (2) of a single conventional chamber.
  • the pressure made from the plunger (21) makes the closing hollow cylinder (6) of the elastic discoid plug (3) to settle on the opening of the central passage tube (7) and to fit it, which is why the valvular joint (1) works together during the injection of the content of the syringe (2), and in which case it does not affect the flow of fluid. This occurs because the fluid flowed perfectly and completely since said elastic discoid plug (3) did not completely close the tube (7).
  • the closing hollow cylinder (6) has the same diameter or a bigger diameter than the central tube (7), which prevents the communication between the chambers (12 and 13) from closing until the direct pressure from the plunger (21) obliges the plug to returns to its initial position.
  • the valvular joint (1) of this invention includes superficial cavities (9 and 10) adjacent to the opening of communication of the cited passage tube (7). So, in case said closing hollow cylinder (6) is supported by the opening of the passage tube (7), the solution fluid (22) normally flows through the mentioned cavities (9 and 10).
  • Figures 14 and 15 show that once the upper closure plug (16) is withdrawn and the injection needle (18) is placed in its position in the distant end of the exit tube (17) of the syringe (2), it will be sufficient for the user to continue moving the plunger (21) in the direction (FI) such that the pressure applied to the solution itself (22) makes it flow through the needle (19) of the injection by crossing it, after having previously removed the protective sheath (19) from said needle (18).
  • Figures 16, 17 and 18 show the valvular joint (1) according to this invention included in a pre-filled conventional syringe (2) of only one chamber (23).
  • the valvular joint (1) formed by elements (3 and 4) is placed in a way that it closes the internal communication of the syringe (2) with the exit tube (17) of the syringe (2), in such a manner that only the chamber (23) is delimited by the valvular joint (1) as the upper base, and by the cylindrical wall of the main body of the syringe (2) and the head (20) of the plunger (21) as the lower base.
  • the user also moves the plunger (21) in the inverse direction (F) of the injection producing an internal depression that generates the elastic deformation of the elastic discoid plug (3), and hence the movement of the closing hollow cylinder (6), which opens a communication through the central passage tube (7).
  • the injectable stored solution (24) can exit towards the needle (18) of the injection, and cross it after having previously removed the protective sheath (19) from said needle (18).
  • Said syringes (2) may have two chambers (12 and 13) or one chamber (23) to contain two separate products that are mixed to obtain either one solution (22) to be injected or one injectable solution (24), respectively.
  • the valvular joint (1) may be used to separate both internal chambers (12 and 13), while the distant chamber (12) of the exit tube (17) of the syringe (2) of the needle (18) is separated by using the valvular closure plug (25) as it is described in the invention patent from Argentina 250777 V1, owned by Jaime Luis Szapiro, Leonardo Szames and Sa ⁇ l Moreno, and entitled "VALVULAR SAFETY PLUG APPLICABLE TO DISPOSABLE PRE-FILLED SYRINGES" ("TAPON V ⁇ LVULA DE SEGURIDAD APLICABLE A JERINGAS PRELLENADAS DESCARTABLES”)
  • said exit tube (17) must include a block, which may occur by means of a valvular closure plug (25) acting in the interior of the exit tube (17) of the syringe (2), where the injection needle (18) is already installed.
  • said valvular closure plug (25) allows the exit of the solution (22) to be injected only when a force (FI) is applied producing an hydraulic pressure from the plunger (21) towards the syringe (2), which partially moves the valvular closure plug (25) and allows the flow of the solution (22) to be injected.
  • this closing valvular plug (25) does not affect the aim and function of the valvular joint (1). Instead, it is an alternative to the making of syringes (2) previously filled and of two chambers (12 and 13) that are separated by the valvular joint (1) according to this invention.
  • the closing valvular plug (25) is particularly characterized by the fact that it partially moves outwards allowing the exit of the solution (22) to be injected, and which was obtained from the mixing of products (14 and 15), through the needle (18). This movement occurs when internal pressure is generated during the action of injection by applying force (FI) on the plunger (21).

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (11)

  1. Ein elastisches und gleitendes Ventilgelenk, das für den Einsatz in Fertigspritzen geeignet ist, die entweder eine innere Kammer zur Aufbewahrung des zu injizierenden Produkts oder zwei voneinander unabhängige innere Kammern mit getrennt aufbewahrten Substanzen enthalten, die jeweils vor der Injektion vermischt werden müssen. Dieses Ventilgelenk dient als temporärer Verschluss, der entweder die Verbindung zwischen der inneren Kammer und dem Verbindungskanal zur Injektionsnadel oder die Verbindung zwischen zwei inneren Kammern blockiert. Das genannte Gelenk besteht aus zwei scheibenförmigen, zusammenwirkenden Elementen, die im Inneren des Hauptkörpers der Spritze angeordnet sind und deren Umfangsrand an der zylindrischen Innenfläche abgestützt ist. Während eines der genannten Elemente ein elastischer, scheibenförmiger Stopfen ist, bildet das andere ein gleitendes, scheibenförmiges Aufnahmelager, auf dem der Stopfen über einen zylindrischen Hohlraum wirkt. Der Umfangsrand des scheibenförmigen Aufnahmelagers bildet einen Wulst, der dicker und weniger elastisch ist als der übrige Körper des genannten scheibenförmigen Aufnahmelagers. Das erwähnte Ventilgelenk ist gekennzeichnet durch den elastischen, scheibenförmigen Stopfen, der eine elastische Basis und einen hohlen Verschlusszylinder mit einer offenen, entfernt liegenden Basis umfasst, welcher sich aus seiner inneren Fläche heraus erstreckt. Das gleitende, scheibenförmige Aufnahmelager umfasst ein zentrales Durchgangsrohr, das dem hohlen Verschlusszylinder gegenüberliegt, sodass die elastische Basis des scheibenförmigen Stopfens lösbar in einem zylindrischen Hohlraum passt, der sich an der Öffnung des zentralen Durchgangsrohrs des gleitenden Aufnahmelagers befindet. Die elastische Basis des scheibenförmigen Stopfens weist dabei einen kleineren Durchmesser auf als das gleitende Aufnahmelager. Wenn sich der hohle Verschlusszylinder innerhalb des zentralen Durchgangsrohrs des gleitenden, scheibenförmigen Aufnahmelagers befindet, ist die elastische Basis des elastischen scheibenförmigen Stopfens in einen ringförmigen Hohlraum eingesetzt, der vom Umfangsrand des Aufnahmelagers umgeben ist, welcher den dickeren Wulst bildet. Der Außendurchmesser des hohlen Verschlusszylinders entspricht dem Innendurchmesser des zentralen Durchgangsrohrs des gleitenden, scheibenförmigen Aufnahmelagers und gewährleistet einen kalibrierten Sitz.
  2. Das elastische Ventilgelenk gemäß Anspruch 1, wobei der hohle Verschlusszylinder, der sich von der elastischen Basis des elastischen, scheibenförmigen Stopfens erstreckt, alternativ einen kreisförmigen Querschnitt aufweisen kann, dessen Außendurchmesser geringfügig größer ist als der Durchmesser des zentralen Durchgangsrohrs des gleitenden, scheibenförmigen Aufnahmelagers, wodurch ein passgenauer Sitz gewährleistet wird.
  3. Das elastische Ventilgelenk gemäß Anspruch 1, wobei der hohle Verschlusszylinder, der sich von der elastischen Basis des Ventilstopfens erstreckt, alternativ eine Mehrzahl externer ringförmiger Flansche aufweisen kann, die vorübergehend von der zylindrischen Innenfläche getragen werden, welche den zentralen Durchgang des gleitenden, scheibenförmigen Aufnahmelagers definiert, wodurch ein passgenauer Sitz ermöglicht wird.
  4. Das elastische Ventilgelenk gemäß einem der vorstehenden Ansprüche 1 bis 3, wobei das zentrale Durchgangsrohr des gleitenden, scheibenförmigen Aufnahmelagers an seiner Öffnung mindestens zwei oberflächennahe, benachbarte Hohlräume aufweist, die einander gegenüberliegen und mit dem Inneren des zentralen Durchgangsrohrs des gleitenden, scheibenförmigen Aufnahmelagers in Verbindung stehen.
  5. Das elastische Ventilgelenk gemäß einem der vorstehenden Ansprüche 1 bis 4, wobei die scheibenförmigen kooperativen Elemente in Kombination mit einem oberen Verschlussstopfen (Tip-Cap), der den Kommunikationskanal zur Injektionsnadel hin verschließt und nicht zuvor in seiner Position installiert ist, eine temporäre Verschlussvorrichtung für Fertigspritzen mit doppelten, innen koaxial angeordneten Kammern darstellen, wobei die genannten scheibenförmigen kooperativen Elemente als Trennwand zwischen diesen Kammern angeordnet sind.
  6. Elastisches Ventilgelenk gemäß einem der vorstehenden Ansprüche 1 bis 4, wobei die scheibenförmigen kooperativen Elemente in Kombination mit einem Ventilverschlussstopfen, der den Kommunikationskanal zur Injektionsnadel hin innen verschließt und in seiner Position vorinstalliert ist, eine temporäre Verschlussvorrichtung für Fertigspritzen mit doppelten, innen koaxial angeordneten Kammern darstellen, wobei die genannten scheibenförmigen kooperativen Elemente als Trennwand zwischen diesen Kammern angeordnet sind.
  7. Das elastische Ventilgelenk gemäß einem der vorstehenden Ansprüche 1 bis 4, wobei die scheibenförmigen kooperativen Elemente, die als temporärer Verschluss angeordnet sind, welcher verhindert, dass der Hauptkörper der Spritze intern mit dem Kommunikationskanal zur Injektionsnadel - die ggf. bereits vorinstalliert ist oder nicht - in Verbindung steht, eine temporäre Verschlussvorrichtung für Ein-Kammer-Fertigspritzen darstellen.
  8. Eine Fertigspritze, die aus einem elastischen Ventilgelenk gemäß einem der vorstehendenAnsprüche 1 bis 4 besteht, welche zwei Hohlräume bildet, die jeweils ein unterschiedliches Produkt enthalten, wobei mindestens eines dieser Produkte flüssig ist. Beim Mischen der Produkte wird eine zu injizierende Lösung erhalten. Der elastische scheibenförmige Stopfen des elastischen Ventilgelenks ist dem Kopf des Kolbens zugewandt.
  9. Eine Fertigspritze gemäß Anspruch 8, wobei die Injektionsnadel in der Austrittsöffnung der Spritze vorinstalliert ist. Genannte Austrittsöffnung ist durch einen inneren Ventilverschlussstopfen verschlossen.
  10. Eine Fertigspritze, wobei das elastische Ventilgelenk gemäß einem der vorstehenden Ansprüche 1 bis 4 einen Hohlraum begrenzt, der eine zu injizierende Lösung enthält, und wobei der elastische, scheibenförmige Stopfen des elastischen Ventilgelenks dem Kopf des Kolbens zugewandt ist.
  11. Die Fertigspritze gemäß Anspruch 9, wobei die Injektionsnadel in der Austrittsöffnung der Spritze vorinstalliert ist.
EP18000270.1A 2017-10-19 2018-03-19 Elastisches und gleitendes ventilgelenk, geeignet zum arbeiten in vorgefüllten spritzen und diese spritzen Active EP3473284B1 (de)

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EP3473284C0 EP3473284C0 (de) 2025-10-01
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AR117044A1 (es) 2019-11-12 2021-07-07 Pharmis Ii Ind E Inovacao Unipessoal Lda Jeringa prellenada que comprende un conjunto valvular elástico y deslizante

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2018134211A1 (en) * 2017-01-19 2018-07-26 Tecnedil International S.R.L. A safety syringe having a retracting needle and being pre-fillable with two active ingredients

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US5643224A (en) * 1994-03-04 1997-07-01 Szapiro; Jaime Luis Safety valve plug for disposable pre-filled syringes
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AR026723A1 (es) 2000-12-05 2003-02-26 Szames Leonardo Conjunto valvular elastico y deslizante apto para actuar en el interior de jeringas prellenadas.
AR082099A1 (es) * 2011-07-04 2012-11-14 Jaime Luis Szapiro Conjunto valvular elastico y deslizante para jeringas prellenadas descartables
AR100575A3 (es) * 2015-03-19 2016-10-19 Luis Szapiro Jaime Recurso valvular de dos elementos de acción cooperante, para operar en jeringas prellenadas descartables

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