EP3394326A4 - Highly parallel assays for simultaneous identification of antibody sequences and binding partners - Google Patents
Highly parallel assays for simultaneous identification of antibody sequences and binding partners Download PDFInfo
- Publication number
- EP3394326A4 EP3394326A4 EP16877036.0A EP16877036A EP3394326A4 EP 3394326 A4 EP3394326 A4 EP 3394326A4 EP 16877036 A EP16877036 A EP 16877036A EP 3394326 A4 EP3394326 A4 EP 3394326A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- binding partners
- antibody sequences
- highly parallel
- simultaneous identification
- parallel assays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003556 assay Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP22194954.8A EP4190951A1 (en) | 2015-12-21 | 2016-12-21 | Highly parallel assays for simultaneous identification of antibody sequences and binding partners |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562270094P | 2015-12-21 | 2015-12-21 | |
PCT/CA2016/000323 WO2017106958A1 (en) | 2015-12-21 | 2016-12-21 | Highly parallel assays for simultaneous identification of antibody sequences and binding partners |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22194954.8A Division EP4190951A1 (en) | 2015-12-21 | 2016-12-21 | Highly parallel assays for simultaneous identification of antibody sequences and binding partners |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3394326A1 EP3394326A1 (en) | 2018-10-31 |
EP3394326A4 true EP3394326A4 (en) | 2019-01-16 |
EP3394326B1 EP3394326B1 (en) | 2022-09-14 |
Family
ID=59088707
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22194954.8A Withdrawn EP4190951A1 (en) | 2015-12-21 | 2016-12-21 | Highly parallel assays for simultaneous identification of antibody sequences and binding partners |
EP16877036.0A Active EP3394326B1 (en) | 2015-12-21 | 2016-12-21 | Highly parallel assays for simultaneous identification of antibody sequences and binding partners |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22194954.8A Withdrawn EP4190951A1 (en) | 2015-12-21 | 2016-12-21 | Highly parallel assays for simultaneous identification of antibody sequences and binding partners |
Country Status (4)
Country | Link |
---|---|
US (2) | US20200149031A1 (en) |
EP (2) | EP4190951A1 (en) |
CA (1) | CA3007846A1 (en) |
WO (1) | WO2017106958A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7038100B2 (en) | 2016-07-21 | 2022-03-17 | バークレー ライツ,インコーポレイテッド | Sorting of T lymphocytes with a microfluidic device |
US20220154174A1 (en) * | 2019-03-08 | 2022-05-19 | Oxford Genetics Limited | Method of Selecting for Antibodies |
EP4121583A1 (en) * | 2020-03-20 | 2023-01-25 | Yale University | Rapid extracellular antibody profiling (reap) for the discovery and use of said antibodies |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100210473A1 (en) * | 2009-01-12 | 2010-08-19 | The Scripps Research Institute | Methods and compositions for identifying binding partners from libraries of biomolecules |
WO2014153651A1 (en) * | 2013-03-28 | 2014-10-02 | The University Of British Columbia | Microfluidic devices and methods for use thereof in multicellular assays of secretion |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19546573A1 (en) | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Crystalline polymorph of terazosin hydrochloride, and process for its preparation |
US10087408B2 (en) | 2010-07-07 | 2018-10-02 | The University Of British Columbia | System and method for microfluidic cell culture |
-
2016
- 2016-12-21 WO PCT/CA2016/000323 patent/WO2017106958A1/en active Application Filing
- 2016-12-21 CA CA3007846A patent/CA3007846A1/en active Pending
- 2016-12-21 EP EP22194954.8A patent/EP4190951A1/en not_active Withdrawn
- 2016-12-21 US US16/063,394 patent/US20200149031A1/en not_active Abandoned
- 2016-12-21 EP EP16877036.0A patent/EP3394326B1/en active Active
-
2021
- 2021-05-17 US US17/321,645 patent/US20210269792A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100210473A1 (en) * | 2009-01-12 | 2010-08-19 | The Scripps Research Institute | Methods and compositions for identifying binding partners from libraries of biomolecules |
WO2014153651A1 (en) * | 2013-03-28 | 2014-10-02 | The University Of British Columbia | Microfluidic devices and methods for use thereof in multicellular assays of secretion |
Non-Patent Citations (3)
Title |
---|
ANUPAM SINGHAL ET AL: "A MICROFLUIDIC PLATFORM FOR SCREENING AND SELECTION OF MONOCLONAL ANTIBODIES FROM SINGLE CELLS", 2 June 2011 (2011-06-02), XP055504387, Retrieved from the Internet <URL:http://www.rsc.org/images/LOC/2011/PDFs/Papers/109_1071.pdf> [retrieved on 20180904] * |
See also references of WO2017106958A1 * |
V?RONIQUE LECAULT ET AL: "Microfluidic single cell analysis: from promise to practice", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 16, no. 3-4, 1 August 2012 (2012-08-01), GB, pages 381 - 390, XP055287401, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2012.03.022 * |
Also Published As
Publication number | Publication date |
---|---|
EP3394326B1 (en) | 2022-09-14 |
EP4190951A1 (en) | 2023-06-07 |
US20200149031A1 (en) | 2020-05-14 |
CA3007846A1 (en) | 2017-06-29 |
EP3394326A1 (en) | 2018-10-31 |
US20210269792A1 (en) | 2021-09-02 |
WO2017106958A1 (en) | 2017-06-29 |
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Inventor name: HEYRIES, KEVIN ALBERT Inventor name: HANSEN, CARL LARS GENGHIS Inventor name: FALCONER, ESTER Inventor name: LECAULT, VERONIQUE Inventor name: LISAINGO, KATHLEEN |
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