EP3356252B1 - Packaging for pharmaceutical products - Google Patents

Description

The invention relates to a package in the form of a blister for pharmaceutical products, and more particularly to a tablet package comprising a plastic film molding and a cover sheet provided with a semi-transparent functional layer.

Under a blister or a visual packaging is meant a product packaging that allows the potential buyer to visually perceive the packaged item or at least to guess the shape of the object. The object is thereby fixed by a sealed with a cover plastic molding. For medicines, e.g. Tablets, the cover is usually made of aluminum. A tablet pack or tablet blister is also called blister pack. The arrangement of the tablets in individual wells or cavities of the plastic molded part, which is sealed by the aluminum foil, is hygienically advantageous because unwanted influences such as high humidity or dirt are excluded.

The production of blisters is eg in the WO 97/010159 A1 described.

The EP 1876 033 A1 describes a packaging material, in particular for the pharmaceutical sector, which has a metallic carrier substrate with a line grid printed in two different visually recognizable colors.

The WO 2006/056216 A1 describes a packaging material for the pharmaceutical sector, wherein applied on both sides of a carrier substrate which can be used as cover film Patterns of different color in each case in reflected light and transmitted light can be seen.

The present invention is based on the general object of making the packaging known in the prior art more customer-friendly. Furthermore, the present invention is the preferred object to increase the security against forgery of the packaging of the prior art.

The object is achieved by the feature combination defined in claim 1. Further developments of the invention are the subject of the dependent claims.

Summary of the invention

The invention comprises a packaging with the features of claim 1.

The plastic film molding has e.g. one or more cavities or cavities, wherein the cavities for receiving objects to be packaged, e.g.

Tablets, are suitable. The plastic film molding is sealed by the cover.

For producing the plastic film molding, e.g. Materials such as PVC (polyvinyl chloride), PVDC (polyvinylidene chloride), PP (polypropylene), PS (polystyrene), COC (cycloolefin copolymer) and PET (polyester) are suitable.

• Polyolefinharz; insbesondere Polypropylen oder einen anorganischen Füllstoff aufweisendes Polypropylen, wobei der anorganische Füllstoff z.B. Calciumcarbonat, Talkum, Aluminiumoxid, Titandioxid, Diatomeenerde, Ton, Kaolin, Kreide, Glasfaser oder ein Gemisch zweier oder mehrerer der vorstehend genannten Stoffe ist;
• Cycloolefin-Copolymer (COC) oder Cycloolefin-Polymer (COP); oder Filme, die wenigstens eine Schicht aus Cycloolefin-Copolymer (COC) oder Cycloolefin-Polymer (COP) enthalten, z.B. Filme mit dem Aufbau COC/PE/COC oder COC/PP/COC oder COC/PE-LLD/COC oder ein Film mit einer COC-Kernschicht (z.B. die folgende Schichtenfolge: polymere Thermoschutzschicht (bevorzugt gewählt von COC, COP, PP, PA oder PET)
• COC-Kernschicht - polymere Heißsiegelschicht), beschrieben in der WO 2009/000403 A1 oder in der WO 2010/139409 A1 ;
• orientiertes Polyethylenterephthalat (OPET); oder ein OPET-Film, der mit einer Polyethylenschicht oder einer Polypropylenschicht zu einem Laminat kombiniert ist, wobei das Laminat gegebenenfalls Schneidrillen bzw. Einschnitte aufweisen kann;
• Polyolefin (A) enthaltende Polymerphase, in der eine Kohlenwasserstoffharz-Komponente (B) in gelöster Form enthalten ist, wobei die Kohlenwasserstoffharz-Komponente (B) von dem Polyolefin (A) verschieden ist, zyklische Seitengruppen an der Polymerkette umfasst und mit einem Anteil von mindestens 3 Gew.-% an der Gesamtmasse im Trägersubstrat enthalten ist, wobei das mittlere Molekulargewicht der Kohlenwasserstoffharz-Komponente (B) kleiner oder gleich 10 000 ist; als Polyolefin (A) werden Polyethylen, Polypropylen oder ein Copolymer oder Terpolymer von Ethylen und/oder Propylen bevorzugt; Komponente (B) ist insbesondere ein amorphes Polymer; solche Durchdrückfolien sind aus der DE 19613 960 A1 bekannt.

The cover film is a push-through film for a blister pack (eg a tablet package), in which the push-through closes the packaged goods (eg pharmaceutical products such as tablets), but can be ruptured or breakable by pushing through the packaged goods. The ability to break open may be additionally increased by mechanical action, for example by means of perforations and / or cutting grooves and / or thinned areas in the covering film (which are obtainable, for example, by embossing). The cover film is based on a transparent or semitransparent carrier substrate provided with the semitransparent functional layer. The carrier substrate is in particular a (semi-) transparent plastic or (semi-) transparent paper. Suitable carrier substrates include, for example, the following materials:

• polyolefin resin; in particular polypropylene or polypropylene having an inorganic filler, wherein the inorganic filler is, for example, calcium carbonate, talc, aluminum oxide, titanium dioxide, diatomaceous earth, clay, kaolin, chalk, glass fiber or a mixture of two or more of the aforementioned substances;
• Cycloolefin copolymer (COC) or cycloolefin polymer (COP); or films containing at least one layer of cycloolefin copolymer (COC) or cycloolefin polymer (COP), for example films of the COC / PE / COC or COC / PP / COC or COC / PE-LLD / COC or film construction with a COC core layer (eg the following layer sequence: polymers Thermal protection layer (preferably selected from COC, COP, PP, PA or PET)
• COC core layer - polymeric heat-sealable layer) described in U.S. Patent Nos. 4,316,391 and 4,805,842 WO 2009/000403 A1 or in the WO 2010/139409 A1 ;
• oriented polyethylene terephthalate (OPET); or an OPET film combined with a polyethylene layer or a polypropylene layer to form a laminate, which laminate may optionally have cutting grooves;
• A polyolefin (A) -containing polymer phase in which a hydrocarbon resin component (B) is contained in a dissolved form, wherein the hydrocarbon resin component (B) is different from the polyolefin (A), comprises pendant cyclic groups on the polymer chain and in a proportion of at least 3% by weight of the total mass in the carrier substrate, wherein the average molecular weight of the hydrocarbon resin component (B) is less than or equal to 10,000; as the polyolefin (A), polyethylene, polypropylene or a copolymer or terpolymer of ethylene and / or propylene are preferred; Component (B) is in particular an amorphous polymer; Such Durchdrückfolien are from the DE 19613 960 A1 known.

1. A) zwei semitransparente metallische Schichten und eine dazwischen angeordnete dielektrische Schicht;
2. B) zwei semitransparente metallische Schichten und eine dazwischen angeordnete, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht (z.B. in blauer Farbe); bevorzugt sind die beiden semitransparenten metallischen Schichten zusätzlich an der Außenseite jeweils mit einer weiteren, bevorzugt 1 bis 2 Mikrometer dicken, Farbschicht, insbesondere in einer Komplementärfarbe zu der zwischen den metallischen Schichten angeordneten Farbschicht (z.B. in gelber Farbe), beschichtet (auf diese Weise ergibt sich der folgende Schichtaufbau mit einem Gold/Blau-Farbwechsel in Auflicht- bzw. Durchlicht-Ansicht: gelbe Druckschicht - semitransparente metallische Schicht - blaue Druckschicht - semitransparente metallische Schicht - gelbe Druckschicht); des Weiteren ist z.B. das folgende, die Schichten a) bis c) umfassende Schichtsystem möglich: a) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (die Metallpigmente beruhen auf einem Metall, das vorzugsweise von der Gruppe bestehend aus Aluminium, Edelstahl, Nichrome, Gold, Silber, Platin und Kupfer gewählt ist; das Metall ist insbesondere bevorzugt Aluminium, wobei der mittlere Teilchendurchmesser bevorzugt in einem Bereich von 8 bis 15 µm, weiter bevorzugt in einem Bereich von 9 bis 10 µm liegt, gemessen mit einem Coulter LS130 Laserdiffraktionsgranulometer; eine solche Druckfarbe ermöglicht die Bereitstellung einer "silbernen" Spiegelschicht), b) blaue, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, c) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (siehe hierzu die Beschreibung zur Schicht a));
3. C) das obige Schichtsystem kann alternativ so ausgestaltet werden, dass einige der Schichten auf der Vorderseite des Trägersubstrats der Abdeckfolie angeordnet sind und einige Schichten auf der Rückseite des Trägersubstrats der Abdeckfolie angeordnet sind; z.B. ist das folgende, die Schichten a) bis f) umfassende Schichtsystem möglich: a) gelbe, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, b) semitransparente metallische Schicht (z.B. Aluminium), c) Trägersubstrat (z.B. (semi-)transparenter Kunststoff), d) blaue, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, e) semitransparente metallische Schicht (z.B. Aluminium), f) gelbe, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht; des Weiteren ist z.B. das folgende, die Schichten a) bis d) umfassende Schichtsystem möglich: a) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (die Metallpigmente beruhen auf einem Metall, das vorzugsweise von der Gruppe bestehend aus Aluminium, Edelstahl, Nichrome, Gold, Silber, Platin und Kupfer gewählt ist; das Metall ist insbesondere bevorzugt Aluminium, wobei der mittlere Teilchendurchmesser bevorzugt in einem Bereich von 8 bis 15 µm, weiter bevorzugt in einem Bereich von 9 bis 10 µm liegt, gemessen mit einem Coulter LS130 Laserdiffraktionsgranulometer; eine solche Druckfarbe ermöglicht die Bereitstellung einer "silbernen" Spiegelschicht), b) Trägersubstrat (z.B. (semi-)transparenter Kunststoff), c) blaue, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, d) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (siehe hierzu die Beschreibung zur Schicht a));
4. D) die oben unter B) und C) genannten Schichtsysteme können selbstverständlich hinsichtlich der gelben Farbschicht und der blauen Farbschicht dahingehend variiert werden, dass anstelle von Gelb bzw. Blau andere Farben verwendet werden, die insbesondere zueinander komplementär sind.

The semitransparent functional layer is available, for example, by vapor deposition or by printing technology. The semitransparent functional layer may have a single-layer or a multilayer structure. In the case of a multi-layered structure, it is possible that all layers are produced by vapor deposition; Alternatively, it is possible that one or more layers are produced by vapor deposition and another or more further layers are produced by printing technology (for example two semi-transparent metallic layers produced by vapor deposition and a pressure-technologically available, nitrocellulose-based dielectric layer). Furthermore, the semitransparent functional layer, for example in the form of a continuous coating or present in the form of a discontinuous coating, for example of metallic pigments or effect pigments. Concrete examples with regard to the semitransparent functional layer are in particular the following layer systems A), B), C) and D):

1. A) two semitransparent metallic layers and a dielectric layer disposed therebetween;
2. B) two semitransparent metallic layers and an intermediate, preferably 1 to 2 micrometer thick, colored layer (eg in blue color); The two semitransparent metallic layers are preferably additionally coated on the outside with a further, preferably 1 to 2 micrometer thick, ink layer, in particular in a complementary color to the ink layer arranged between the metallic layers (eg in yellow color) (in this way results the following layer structure with a gold / blue color change in reflected light or transmitted light view: yellow print layer - semitransparent metallic layer - blue print layer - semitransparent metallic layer - yellow print layer); Furthermore, it is possible, for example, to use the following layer system comprising layers a) to c): a) yellow-colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, which are obtained from WO 2005/051675 A2 The metal pigments are based on a metal, which is preferably selected from the group consisting of aluminum, stainless steel, nichrome, gold, silver, platinum and copper, the metal is particularly preferably aluminum, wherein the average particle diameter is preferably in a range of 8 to 15 μm, more preferably in a range of 9 to 10 μm, measured with a Coulter LS130 laser diffraction granulometer, such a printing ink makes it possible to provide a "silver" mirror layer, b) blue, preferably 1 to 2 micrometer thick, colored layer, c) yellow colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, from the WO 2005/051675 A2 are known (see the description of layer a));
3. C) the above layer system may alternatively be configured such that some of the layers are arranged on the front side of the carrier substrate of the cover film and some layers are arranged on the rear side of the carrier substrate of the cover film; For example, the following layer system comprising layers a) to f) is possible: a) yellow, preferably 1 to 2 micrometer thick, color layer, b) semitransparent metallic layer (eg aluminum), c) carrier substrate (eg (semi-) transparent plastic ), d) blue, preferably 1 to 2 micrometers thick, ink layer, e) semi-transparent metallic layer (eg aluminum), f) yellow, preferably 1 to 2 micrometers thick, ink layer; Furthermore, it is possible, for example, to use the following layer system comprising layers a) to d): a) yellow-colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, which are obtained from WO 2005/051675 A2 The metal pigments are based on a metal, which is preferably selected from the group consisting of aluminum, stainless steel, nichrome, gold, silver, platinum and copper, the metal is particularly preferably aluminum, wherein the average particle diameter is preferably in a range of 8 up to 15 μm, more preferably in a range of 9 to 10 μm, measured with a Coulter LS130 laser diffraction granulometer, such printing ink makes it possible to provide a "silver" mirror layer, b) carrier substrate (eg (semi-) transparent plastic), c ) blue, preferably 1 to 2 micrometer thick, color layer, d) yellow colored, "silver" mirror layer, obtainable by means of yellow colored metal pigments, from the WO 2005/051675 A2 are known (see the description of layer a));
4. D) the layer systems mentioned above under B) and C) can of course be varied with regard to the yellow color layer and the blue color layer in that instead of yellow or blue, other colors are used, which are in particular complementary to one another.

For the sealing of the plastic film molding with the cover film, the cover film may in particular have a heat-sealing lacquer (or heat-sealable binder), which is optionally arranged on the cover film by means of a hot-seal lacquer primer (or adhesion promoter). Instead of the formulation "heat-sealable binder and optionally present adhesion promoter", the term "heat-seal coating" is also used herein.

The covering film may have, in particular, visually recognizable markings in the form of patterns, characters or a coding which are obtainable by irradiation with laser radiation. The visually recognizable markings are generated in the semitransparent functional layer, in particular in the form of transparent markings, which are visible to the observer both in incident light and in transmitted light.

Preferred embodiments of the invention are evident from the dependent claims.

Detailed description of the invention

An observation in reflected light in the sense of this invention is a lighting of the respective object from one side and a viewing of the object from the same side. A reflection in incident light is thus present, for example, when the back of the packaging is illuminated and also viewed.

A reflection in the transmitted light in the sense of this invention is an illumination of the respective object from one side and a viewing of the object from the opposite side. A reflection in transmitted light is thus, for example, when the front of the package illuminated and the back of the package is considered. The light thus appears at least partially through the package.

The packaging according to the invention is characterized in that it has a semitransparent cover film with a color change when viewed in reflected light (reflection) on the one hand and when viewed in transmitted light (transmission) on the other. Since a e.g. in a cavity of the plastic molding of the package, e.g. a tablet, the light transmission decreases, the viewer perceives the article when viewing the packaging with a view of the cover in the transmitted light substantially in the reflection color of the cover. The area of the cover film outside the object appears to the viewer in the transmission color of the cover film.

The rapid and uncomplicated finding of the article contained in the package is particularly advantageous in the case of a pharmaceutical product such as a tablet, e.g. as a life-saving immediate measure or in case of a consciousness disturbance of the consumer due to the influence of alcohol, illness or shock.

In addition, the tablet packaging according to the invention is particularly advantageous because of their increased security against forgery, since semitransparent cover films are relatively difficult to access with color change when viewed in incident light on the one hand and when viewed in transmitted light on the other hand for the counterfeiter. In addition, an uncomplicated authenticity check of the tablet package according to the invention by the consumer, even in the case of a child, by viewing the tablet package with a view of the cover in reflected light and transmitted light without additional technical aids feasible.

• die Bereitstellung einer zusätzlichen opaken Beschichtung, insbesondere eine Druckschicht oder eine Metallisierung, die Aussparungen in Form von Mustern, Zeichen oder einer Codierung aufweist;
• das Bedrucken der Abdeckfolie mit (Mikro-)Schrift, insbesondere mit Effektpigmenten;
• das Bereitstellen lumineszierender oder magnetischer Sicherheitsmerkmale, die insbesondere maschinell erfassbar sind;
• das Bereitstellen eines zusätzlichen Hologramms, insbesondere eine Prägelackschicht mit einer diffraktiven Reliefstruktur, die ggf. mit einer Metallisierung versehen ist;
• das Bereitstellen einer mikrooptischen Reliefstruktur, insbesondere einer Mikrospiegel-Anordnung; die Herstellung einer mikrooptischen Reliefstruktur ist im Stand der Technik bekannt (siehe z.B. die WO 2014/060089 A2 );
• das Bereitstellen einer zusätzlichen Papierschicht, die ggf. (z.B. mittels Stanzen oder Laserschnitt erzeugbare) Aussparungen oder Wasserzeichen aufweist;
• das Behandeln der Abdeckfölie mit Laserstrahlung, um auf diese Weise visuell erkennbare Markierungen in Form von Mustern, Zeichen oder einer Codierung in der semitransparenten Funktionsschicht zu erzeugen; eine solche Laser-Behandlung kann auch in Form eines finalen Bearbeitungsschritts bei einer fertiggestellten Blisterverpackung erfolgen, um die Abdeckfolie z.B. mit einem (z.B. zweidimensionalen) Barcode zu versehen; mittels der Laser-Behandlung ließe sich auch pro Tablette eine Markierung, insbesondere eine Codierung, in der Abdeckfolie erzeugen; als Laser eignet sich z.B. ein Nd:YAG-Laser (Neodym-dotierter Yttrium-Aluminium-Granat-Laser), d.h. ein Festkörperlaser, der als aktives Medium einen Neodym-dotierten YAG-Kristall verwendet und meist infrarote Strahlung mit der Wellenlänge 1064 nm emittiert; die Behandlung der Abdeckfolie mit Laserstrahlung führt z.B. zur Bereitstellung von transparenten Markierungen in der semitransparenten Funktionsschicht, die sowohl im Auflicht als auch im Durchlicht für den Betrachter sichtbar sind.

To increase the counterfeit protection, the cover can be equipped with additional anti-counterfeiting agents, eg

• the provision of an additional opaque coating, in particular a printing layer or a metallization, which has recesses in the form of patterns, characters or a coding;
• the printing of the cover with (micro) writing, in particular with effect pigments;
• the provision of luminescent or magnetic security features that are particularly detectable by machine;
• the provision of an additional hologram, in particular an embossing lacquer layer with a diffractive relief structure, which is optionally provided with a metallization;
• the provision of a micro-optical relief structure, in particular a micromirror arrangement; the preparation of a micro-optical relief structure is known in the art (see, for example, the WO 2014/060089 A2 );
• the provision of an additional paper layer, which optionally has cutouts or watermarks (eg, which can be produced by means of punching or laser cutting);
• treating the cover film with laser radiation so as to produce visually recognizable markings in the form of patterns, characters or an encoding in the semitransparent functional layer; Such a laser treatment can also take the form of a final processing step in a finished blister pack, for example, to provide the cover sheet with a (eg two-dimensional) barcode; By means of the laser treatment, it would also be possible to produce a marking, in particular a coding, in the cover film per tablet; as a laser For example, a Nd: YAG laser (neodymium-doped yttrium-aluminum-garnet laser) is suitable, ie a solid-state laser which uses a neodymium-doped YAG crystal as the active medium and usually emits infrared radiation with a wavelength of 1064 nm; For example, the treatment of the cover film with laser radiation leads to the provision of transparent markings in the semitransparent functional layer, which are visible to the observer both in reflected light and in transmitted light.

The cover film may further be equipped with RFID antennas or RFID tags.

With regard to its objective nature, the covering film can be designed such that its mechanical and / or optical state as a result of the oxidative processes or due to the influence of moisture, serves as a proof of durability to the consumer. Thus, e.g. the semitransparent functional layer contains a metal that changes optically due to the influence of oxygen and / or moisture.

For the sealing of the plastic film molding with the cover film, the cover film may in particular have a heat seal coating, for example a heat seal binder (also called heat seal lacquer), which is arranged on the cover film by means of an optional adhesion promoter (also referred to herein as heat seal lacquer primer). For example, a combination of a PVC-based adhesion promoter and the heat sealable binder commercially available from Evonik under the trade name "DEGALAN® P24" is suitable for drug blister packaging. Also suitable for pharmaceutical blister packs is, for example, those based on heat sealable bead polymers, commercially available from Evonik offers heat-sealable binders under the trade name "DEGALAN® VP P34", for which a previous primer with an adhesion promoter is not required.

The cover sheet may e.g. have a thickness in the range of 5 microns to 100 microns, preferably from 5 microns to 60 microns, more preferably in the range of 10 microns to 30 microns, most preferably in the range of 15 microns to 25 microns. For producing the plastic film molding, e.g. Materials such as PVC (polyvinyl chloride), PVDC (polyvinylidene chloride), PP (polypropylene), PS (polystyrene), COC (cycloolefin copolymer) and PET (polyester) are suitable. The shaping can be done by means of thermoforming technology.

The cover film is based on a transparent or semitransparent carrier substrate provided with the semitransparent functional layer.

• Polyolefinharz; insbesondere Polypropylen oder einen anorganischen Füllstoff aufweisendes Polypropylen, wobei der anorganische Füllstoff z.B. Calciumcarbonat, Talkum, Aluminiumoxid, Titandioxid, Diatomeenerde, Ton, Kaolin, Kreide, Glasfaser oder ein Gemisch zweier oder mehrerer der vorstehend genannten Stoffe ist; durch den zusätzlichen Einbau von anorganischen Füllstoffen können die mechanischen Eigenschaften des Trägersubstrats, wie etwa die Steifigkeit, eingestellt werden; der FüllstoffAnteil im Trägersubstrat beträgt vorzugsweise 30 Gew.-% bis 60 Gew.-%; die mittlere Teilchengröße des anorganischen Füllstoffs beträgt vorzugsweise 0,1 Mikrometer bis 50 Mikrometer; mit steigendem Füllstoff-Gehalt nimmt die Opazität des Trägersubstrats zu, daher wird ein zu hoher Füllstoff-Gehalt nicht bevorzugt;

• Cycloolefin-Copolymer (COC) oder Cycloolefin-Polymer (COP); oder Filme, die wenigstens eine Schicht aus Cycloolefin-Copolymer (COC) oder Cycloolefin-Polymer (COP) enthalten, z.B. Filme mit dem Aufbau COC/PE/COC oder COC/PP/COC oder COC/PE-LLD/COC oder ein Film mit einer COC-Kernschicht (z.B. die folgende Schichtenfolge: polymere Thermoschutzschicht (bevorzugt gewählt von COC, COP, PP, PA oder PET) - COC-Kernschicht - polymere Heißsiegelschicht), beschrieben in der WO 2009/000403 A1 oder in der WO 2010/139409 A1 (die Abkürzung PE-LLD steht für lineares Polyethylen niedriger Dichte);
• orientiertes Polyethylenterephthalat (OPET); oder ein OPET-Film, der mit einer Polyethylenschicht oder einer Polypropylenschicht zu einem Laminat kombiniert ist, wobei das Laminat gegebenenfalls Schneidrillen bzw. Einschnitte aufweisen kann; Schneidrillen bzw. Einschnitte können mittels eines Messers oder mittels Laserstrahlung eingebracht werden;
• orientierter Kunststoff-Film, enthaltend ein Polyethylen-2,6-naphthalat-Harz als eine Hauptkomponente;
• einaxial orientierter Polypropylenfilm, bestrahlt mit ionisierender Strahlung;
• orientierter Polyethylenterephthalatfilm (OPET-Film), beschichtet mit einem Polyesteranker-Deckagens und einer PE-Schicht;
• orientierter Polyethylenterephthalatfilm (OPET-Film), beschichtet mit einem Polyethylenanker-Deckagens und einer PP-Schicht;
• poröser Kunststofffilm (z.B. Polyethylenterephtalatfilm oder Polypropylenfilm), der zum Abdecken der kleinen Poren mit einem geschmolzenen Harz beschichtet ist (z.B. Olefinharz, wie ein Polyethylenharz oder ein Polypropylenharz);
• Polyolefin (A) enthaltende Polymerphase, in der eine Kohlenwasserstoffharz-Komponente (B) in gelöster Form enthalten ist, wobei die Kohlenwasserstoffharz-Komponente (B) von dem Polyolefin (A) verschieden ist, zyklische Seitengruppen an der Polymerkette umfasst und mit einem Anteil von mindestens 3 Gew.-% an der Gesamtmasse im Trägersubstrat enthalten ist, wobei das mittlere Molekulargewicht der Kohlenwasserstoffharz-Komponente (B) kleiner oder gleich 10 000 ist; als Polyolefin (A) werden Polyethylen, Polypropylen oder ein Copolymer oder Terpolymer von Ethylen und/oder Propylen bevorzugt; Komponente (B) ist insbesondere ein amorphes Polymer; solche Durchdrückfolien sind aus der DE 19613 960 A1 bekannt.

The carrier substrate is in particular a (semi-) transparent plastic or (semi-) transparent paper. Suitable carrier substrates include, for example, the following materials:

• polyolefin resin; in particular polypropylene or polypropylene having an inorganic filler, wherein the inorganic filler is, for example, calcium carbonate, talc, aluminum oxide, titanium dioxide, diatomaceous earth, clay, kaolin, chalk, glass fiber or a mixture of two or more of the aforementioned substances; by the additional incorporation of inorganic fillers, the mechanical properties of the carrier substrate, such as the stiffness, can be adjusted; the filler content in the carrier substrate is preferably from 30% to 60% by weight; the average particle size of the inorganic filler is preferably 0.1 micrometer to 50 micrometers; with increasing filler content decreases the Opacity of the carrier substrate, therefore, too high a filler content is not preferred;

• Cycloolefin copolymer (COC) or cycloolefin polymer (COP); or films containing at least one layer of cycloolefin copolymer (COC) or cycloolefin polymer (COP), for example films of the COC / PE / COC or COC / PP / COC or COC / PE-LLD / COC or film construction with a COC core layer (eg the following layer sequence: polymeric thermal protection layer (preferably selected from COC, COP, PP, PA or PET) - COC core layer - polymeric heat seal layer), described in US Pat WO 2009/000403 A1 or in the WO 2010/139409 A1 (the abbreviation PE-LLD stands for linear low density polyethylene);
• oriented polyethylene terephthalate (OPET); or an OPET film combined with a polyethylene layer or a polypropylene layer to form a laminate, which laminate may optionally have cutting grooves; Cutting grooves or cuts can be introduced by means of a knife or by means of laser radiation;
• oriented plastic film containing a polyethylene-2,6-naphthalate resin as a main component;
• uniaxially oriented polypropylene film irradiated with ionizing radiation;
• oriented polyethylene terephthalate film (OPET film) coated with a polyester anchor capping agent and a PE layer;
• oriented polyethylene terephthalate (OPET) film coated with a polyethylene anchor cover and a PP layer;
• porous plastic film (eg, polyethylene terephthalate film or polypropylene film) coated with a molten resin for covering the small pores (eg, olefin resin such as a polyethylene resin or a polypropylene resin);
• A polyolefin (A) -containing polymer phase in which a hydrocarbon resin component (B) is contained in a dissolved form, wherein the hydrocarbon resin component (B) is different from the polyolefin (A), comprises pendant cyclic groups on the polymer chain and in a proportion of at least 3% by weight of the total mass in the carrier substrate, wherein the average molecular weight of the hydrocarbon resin component (B) is less than or equal to 10,000; as the polyolefin (A), polyethylene, polypropylene or a copolymer or terpolymer of ethylene and / or propylene are preferred; Component (B) is in particular an amorphous polymer; Such Durchdrückfolien are from the DE 19613 960 A1 known.

The semitransparent functional layer, on the other hand, has different hues when viewed in reflected light on the one hand and when viewed in transmitted light on the other hand. The two different shades are, for example, complementary colors. Such a semitransparent functional layer is based, for example, on a multilayer structure with two semitransparent metallic layers and a dielectric layer arranged between the two semitransparent metallic layers. Such a multi-layered structure, which appears golden when viewed in reflected light and shows a blue hue when viewed in transmitted light, is for example from the WO 2011/082761 A1 known. In addition, the describes WO 2011/032665 A1 similar multi-layered structures.

• die beiden semitransparenten metallischen Schichten werden bevorzugt von Al oder Ag gewählt; die dielektrische Schicht ist insbesondere eine SiO₂-Schicht oder eine MgF₂-Schicht, bevorzugt eine SiO₂-Schicht;
• im Falle, dass jede der beiden semitransparenten metallischen Schichten auf Al beruht, liegt die jeweilige bevorzugte Schichtdicke in einem Bereich von 5 nm bis 20 nm, insbesondere bevorzugt in einem Bereich von 10 nm bis 14 nm; die dielektrische SiO₂-Schicht hat vorzugsweise eine Schichtdicke in einem Bereich von 50 nm bis 450 nm, weiter bevorzugt in einem Bereich von 80 nm bis 260 nm und insbesondere bevorzugt in einem Bereich von 210 nm bis 260 nm, wobei die Bereiche von 80 nm bis 100 nm und von 210 nm bis 240 nm speziell für die Bereitstellung eines Gold/Blau-Farbwechsels besonders bevorzugt werden;
• im Falle, dass jede der beiden semitransparenten metallischen Schichten auf Ag beruht, liegt die jeweilige bevorzugte Schichtdicke in einem Bereich von 15 nm bis 30 nm, insbesondere bevorzugt von 15 nm bis 25 nm; die dielektrische SiO₂-Schicht hat vorzugsweise eine Schichtdicke in einem Bereich von 50 nm bis 450 nm, weiter bevorzugt in einem Bereich von 80 nm bis 260 nm und insbesondere bevorzugt in einem Bereich von 210 nm bis 260 nm, wobei die Bereiche von 80 nm bis 100 nm und von 210 nm bis 240 nm speziell für die Bereitstellung eines Gold/Blau-Farbwechsels besonders bevorzugt werden.

Suitable multilayer structures having two semi-transparent metallic layers and a dielectric layer arranged between the two semitransparent metallic layers preferably have the following physical properties:

• the two semitransparent metallic layers are preferably selected from Al or Ag; the dielectric layer is in particular an SiO ₂ layer or an MgF ₂ layer, preferably an SiO ₂ layer;
• in the case where each of the two semitransparent metallic layers is based on Al, the respective preferred layer thickness is in a range of 5 nm to 20 nm, particularly preferably in a range of 10 nm to 14 nm; the SiO ₂ dielectric layer preferably has a layer thickness in a range of 50 nm to 450 nm, more preferably in a range of 80 nm to 260 nm, and particularly preferably in a range of 210 nm to 260 nm, wherein the ranges of 80 nm up to 100 nm and from 210 nm to 240 nm are especially preferred for providing a gold / blue color change;
• in the case where each of the two semitransparent metallic layers is based on Ag, the respective preferred layer thickness is in a range of 15 nm to 30 nm, particularly preferably 15 nm to 25 nm; the SiO ₂ dielectric layer preferably has a layer thickness in a range of 50 nm to 450 nm, more preferably in a range of 80 nm to 260 nm, and particularly preferably in a range of 210 nm to 260 nm, wherein the ranges of 80 nm to 100 nm and from 210 nm to 240 nm are especially preferred for providing a gold / blue color change.

• ein Silber/Dielektrikum/Aluminium-Schichtsystem, wobei die Schichtdicken der Silber-Schicht und der Aluminium-Schicht identisch oder verschieden sind;
• ein Silber/Dielektrikum/Silber-Schichtsystem, wobei die Schichtdicken der beiden Silber-Schichten verschieden sind;
• ein Aluminium/Dielektrikum/ Aluminium-Schichtsystem, wobei die Schichtdicken der beiden Aluminium-Schichten verschieden sind.

The above-mentioned multilayer structures having two semi-transparent metallic layers and a dielectric layer disposed between the two semitransparent metallic layers may have a symmetrical three-layer structure in which both the material and the layer thickness of the two semitransparent metallic layers are identical. Alternatively, however, there may also be an asymmetric three-layer structure in which the material and / or the Layer thickness of the two semitransparent metallic layers are different, eg

• a silver / dielectric / aluminum layer system, wherein the layer thicknesses of the silver layer and the aluminum layer are identical or different;
• a silver / dielectric / silver layer system, wherein the layer thicknesses of the two silver layers are different;
• an aluminum / dielectric / aluminum layer system, wherein the layer thicknesses of the two aluminum layers are different.

• im Auflicht Magenta, im Durchlicht Blau-Grün;
• im Auflicht Türkis, im Durchlicht Orange-Gelb;
• im Auflicht Gold, im Durchlicht Blau-Violett;
• im Auflicht Silber, im Durchlicht Violett.

The abovementioned multi-layered layer structures not only make it possible to produce a semitransparent functional layer that appears gold-colored when viewed in reflected light and shows a blue hue when viewed in transmitted light, but further color changes can be produced depending on the choice of the layer thickness, in particular of the dielectric layer, eg

• magenta in reflected light, blue-green in transmitted light;
• in incident light turquoise, in transmitted light orange-yellow;
• in reflected light gold, in transmitted light blue-violet;
• in reflected light silver, in transmitted light violet.

• Kopfschmerztabletten: Tablettenverpackung mit einer Abdeckfolie, die im Auflicht goldbarben und im Durchlicht blau erscheint;
• Tabletten gegen Magenschmerzen: Tablettenverpackung mit einer Abdeckfolie, die im Auflicht Türkis und im Durchlicht Orange-Gelb erscheint;
• Schlaftabletten: Tablettenverpackung mit einer Abdeckfolie, die im Auflicht Magenta und im Durchlicht Blau-Grün erscheint.

The various color changes mentioned above can be used by a pharmaceutical manufacturer to provide his pharmaceuticals in the form of various tablet packagings according to a defined color coding, whereby, for example, the following color coding is conceivable:

• Headache tablets: tablet packaging with a cover foil that turns golden in incident light and appears blue in transmitted light;
• Tablets for stomach ache: tablet wrap with a cover foil that appears in incident light turquoise and orange-yellow in transmitted light;
• Sleeping pills: tablet packaging with a cover film that appears magenta in transmitted light and blue-green in transmitted light.

The above color coding allows the consumer, in the case of a disturbance of consciousness, e.g. to avoid the accidental use of tablets for stomach pain instead of headache tablets.

A semitransparent functional layer which has different shades when viewed in reflected light on the one hand and when viewed in transmitted light on the other hand, can also be based on an effect pigment composition. Printed layers based on an effect pigment composition which, when viewed in incident light, show a different color than when viewed in transmitted light, in particular a gold / blue color change, a gold / violet color change, a green / gold / magenta color change, a Violet / green color change or a silver / opaque color change, are eg in the WO 2011/064162 A2 described. The pigments preferably have a longest dimension of edge length from end-to-end in a range of 15 nm to 1000 nm and are based on a transition metal selected from the group consisting of Cu, Ag, Au, Zn, Cd, Ti, Cr, Mn, Fe, Co, Ni, Ru, Rh, Pd, Os, Ir and Pt. The transition metal is preferably Ag. The aspect ratio (ie the ratio of the longest dimension from end to end relative to the thickness) is preferably at least 1.5, in particular in a range from 1.5 to 300. The ratio of the binder to metal pigment is preferably below 10: 1, in particular below 5: 1. Depending on the choice of the aspect ratio of the pigment, its longest end-to-end dimension and pigment / binder ratio adjustment, the color can be tuned to the print layer in transmission and the color when viewed in reflection (eg, blue in transmission and silver, gold, bronze, copper, or Violet in reflection, in addition violet, magenta, pink, green or brown in transmission and different colors in reflection, which depend on the choice of pigment / binder ratio). Colors with gold / blue color change between reflection and transmission (in other words, between incident light and transmitted light observation) are, for example, in Examples 1, 2 and 3 in Table 1 of FIG WO 2011/064162 A2 called. Further, Example 4 shows a color with gold / violet color change, Example 5 a color with green-gold / magenta color change, Example 7 a color with violet / green color change and Example 8 a color with silver / opaque color change.

• Kopfschmerztabletten: Tablettenverpackung mit einer Abdeckfolie, die im Auflicht goldfarben und im Durchlicht blau erscheint;
• Tabletten gegen Magenschmerzen: Tablettenverpackung mit einer Abdeckfolie, die im Auflicht grün-gold und im Durchlicht magenta erscheint;
• Schlaftabletten: Tablettenverpackung mit einer Abdeckfolie, die im Auflicht violett und im Durchlicht grün erscheint.

The various color changes mentioned above can be used by a pharmaceutical manufacturer to provide his pharmaceuticals in the form of various tablet packagings according to a defined color coding, whereby, for example, the following color coding is conceivable:

• Headache tablets: tablet packaging with a cover foil that appears golden in reflected light and blue in transmitted light;
• Tablets for stomach ache: tablet packaging with a cover foil that appears green-gold in reflected light and magenta in transmitted light;
• Sleeping pills: Tablet packaging with a cover foil that appears violet in transmitted light and green in transmitted light.

The above color coding allows the consumer, in the case of a disturbance of consciousness, e.g. to avoid the accidental use of tablets for stomach pain instead of headache tablets.

1. 1) zwei semitransparente metallische Schichten (z.B. 5 nm bis 15 nm Al) und eine dazwischen angeordnete, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht (z.B. in blauer Farbe); bevorzugt sind die beiden semitransparenten metallischen Schichten zusätzlich an der Außenseite jeweils mit einer weiteren, bevorzugt 1 bis 2 Mikrometer dicken, Farbschicht, insbesondere in einer Komplementärfarbe zu der zwischen den metallischen Schichten angeordneten Farbschicht (z.B. in gelber Farbe), beschichtet (auf diese Weise ergibt sich der folgende Schichtaufbau mit einem Gold/Blau-Farbwechsel in Auflicht- bzw. Durchlicht-Ansicht: gelbe Druckschicht - semitransparente metallische Schicht - blaue Druckschicht - semitransparente metallische Schicht - gelbe Druckschicht); des Weiteren ist z.B. das folgende, die Schichten a) bis c) umfassende Schichtsystem möglich:
   1. a) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (die Metallpigmente beruhen auf einem Metall, das vorzugsweise von der Gruppe bestehend aus Aluminium, Edelstahl, Nichrome, Gold, Silber, Platin und Kupfer gewählt ist; das Metall ist insbesondere bevorzugt Aluminium, wobei der mittlere Teilchendurchmesser bevorzugt in einem Bereich von 8 bis 15 µm, weiter bevorzugt in einem Bereich von 9 bis 10 µm liegt, gemessen mit einem Coulter LS130 Laserdiffraktionsgranulometer; eine solche Druckfarbe ermöglicht die Bereitstellung einer "silbernen" Spiegelschicht),
   2. b) blaue, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, c) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (siehe hierzu die Beschreibung zur Schicht a));
2. 2) das obige Schichtsystem kann alternativ so ausgestaltet werden, dass einige der Schichten auf der Vorderseite des Trägersubstrats der Abdeckfolie angeordnet sind und einige Schichten auf der Rückseite des Trägersubstrats der Abdeckfolie angeordnet sind; z.B. ist das folgende, die Schichten a) bis f) umfassende Schichtsystem möglich: a) gelbe, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, b) semitransparente metallische Schicht (z.B. 5 nm bis 15 nm Aluminium), c) Trägersubstrat (z.B. (semi-)transparenter Kunststoff), d) blaue, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, e) semitransparente metallische Schicht (z.B. 5 nm bis 15 nm Aluminium), f) gelbe, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht; des Weiteren ist z.B. das folgende, die Schichten a) bis d) umfassende Schichtsystem möglich: a) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (die Metallpigmente beruhen auf einem Metall, das vorzugsweise von der Gruppe bestehend aus Aluminium, Edelstahl, Nichrome, Gold, Silber, Platin und Kupfer gewählt ist; das Metall ist insbesondere bevorzugt Aluminium, wobei der mittlere Teilchendurchmesser bevorzugt in einem Bereich von 8 bis 15 µm, weiter bevorzugt in einem Bereich von 9 bis 10 µm liegt, gemessen mit einem Coulter LS130 Laserdiffraktionsgranulometer; eine solche Druckfarbe ermöglicht die Bereitstellung einer "silbernen" Spiegelschicht), b) Trägersubstrat (z.B. (semi-)transparenter Kunststoff), c) blaue, bevorzugt 1 bis 2 Mikrometer dicke, Farbschicht, d) gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (siehe hierzu die Beschreibung zur Schicht a));
3. 3) die oben unter 1) und 2) genannten Schichtsysteme können selbstverständlich hinsichtlich der gelben Farbschicht und der blauen Farbschicht dahingehend variiert werden, dass anstelle von Gelb bzw. Blau andere Farben verwendet werden, die insbesondere zueinander komplementär sind.

A semitransparent functional layer, which has different shades when viewed in reflected light on the one hand and when viewed in transmitted light, on the other hand, can also be based, at least in part, on the use of conventional color layers or colored lacquers and according to one of the following variants:

1. 1) two semitransparent metallic layers (eg 5 nm to 15 nm Al) and an intermediate, preferably 1 to 2 micrometer thick, colored layer (eg in blue color); The two semitransparent metallic layers are preferably additionally coated on the outside with a further, preferably 1 to 2 micrometer thick, ink layer, in particular in a complementary color to the ink layer arranged between the metallic layers (eg in yellow color) (in this way results the following layer structure with a gold / blue color change in reflected light or transmitted light view: yellow print layer - semitransparent metallic layer - blue print layer - semitransparent metallic layer - yellow print layer); Furthermore, for example, the following layer system comprising layers a) to c) is possible:
   1. a) yellow - colored, "silver" mirror layer, obtainable by means of yellow - colored metal pigments, which are derived from WO 2005/051675 A2 The metal pigments are based on a metal, which is preferably selected from the group consisting of aluminum, stainless steel, nichrome, gold, silver, platinum and copper, the metal is particularly preferably aluminum, wherein the average particle diameter is preferably in a range of 8 to 15 μm, more preferably in a range of 9 to 10 μm, measured with a Coulter LS130 laser diffraction granulometer; Printing ink enables the provision of a "silver" mirror layer),
   2. b) blue, preferably 1 to 2 micrometer thick, color layer, c) yellow colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, from the WO 2005/051675 A2 are known (see the description of layer a));
2. 2) the above layer system may alternatively be configured such that some of the layers are arranged on the front side of the carrier substrate of the cover film and some layers are arranged on the back side of the carrier substrate of the cover film; For example, the following layer system comprising layers a) to f) is possible: a) yellow, preferably 1 to 2 micrometer thick, ink layer, b) semitransparent metallic layer (eg 5 nm to 15 nm aluminum), c) carrier substrate (eg semi-) transparent plastic), d) blue, preferably 1 to 2 micrometer thick, ink layer, e) semitransparent metallic layer (eg 5 nm to 15 nm aluminum), f) yellow, preferably 1 to 2 micrometer thick, ink layer; Furthermore, it is possible, for example, to use the following layer system comprising layers a) to d): a) yellow-colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, which are obtained from WO 2005/051675 A2 The metal pigments are based on a metal, which is preferably selected from the group consisting of aluminum, stainless steel, nichrome, gold, silver, platinum and copper, the metal is particularly preferably aluminum, wherein the average particle diameter is preferably in a range of 8 up to 15 μm, more preferably in a range of 9 to 10 μm, measured with a Coulter LS130 laser diffraction granulometer, such printing ink makes it possible to provide a "silver" mirror layer, b) carrier substrate (eg (semi-) transparent plastic), c ) blue, preferably 1 to 2 micrometers thick, color layer, d) yellow colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, the of the WO 2005/051675 A2 are known (see the description of layer a));
3. 3) the layer systems mentioned above under 1) and 2) can, of course, be varied with regard to the yellow color layer and the blue color layer in that, instead of yellow or blue, other colors are used, which in particular are complementary to one another.

• Primerschicht bzw. Schutzlack (optional, d.h. nicht zwingend erforderlich; die Primerschicht kann insbesondere eine Farbannahmeschicht sein, die für das Bedrucken mit Druckfarbe geeignet ist; auf diese Weise kann die Bedruckbarkeit der Abdeckfolie mit Schrift (z.B. Hersteller und Markenname eines Arzneimittels) weiter verbessert werden);
• Trägersubstrat, z.B. Polypropylen, das ggf. mit anorganischen Füllstoffen ausgestattet ist;
• semitransparente Funktionsschicht (z.B. Al/SiO₂/Al-Schichtfolge oder Ag/SiO₂/Ag-Schichtfolge, insbesondere mit Gold/Blau-Farbwechsel in Auflicht/ Durchlicht-Betrachtung);
• Heißsiegellackgrundierung (optional);
• Heißsiegellack (zum Kunststofffolienformteil gerichtet).

A covering film which can be used for the tablet packaging according to the invention can, for example, have the following multilayer structure:

• Primer layer or protective varnish (optional, ie not mandatory, the primer layer may in particular be a color receiving layer which is suitable for printing with printing ink, in this way the printability of the cover film with writing (eg manufacturer and brand name of a drug) can be further improved );
• Carrier substrate, for example polypropylene, which is optionally equipped with inorganic fillers;
• semitransparent functional layer (eg Al / SiO ₂ / Al layer sequence or Ag / SiO ₂ / Ag layer sequence, in particular with gold / blue color change in reflected light / transmitted-light observation);
• Heat sealing lacquer primer (optional);
• Heat sealing lacquer (directed to the plastic film molding).

The order of the above layers may be varied, if necessary. Thus, the semitransparent functional layer may e.g. between the primer layer and the carrier substrate.

• Primerschicht (optional);
• eine Papierschicht;
• Trägersubstrat, z.B. Polypropylen, das ggf. mit anorganischen Füllstoffen ausgestattet ist;
• semitransparente Funktionsschicht (z.B. Al/SiO₂/Al-Schichtfolge oder Ag/SiO₂/Ag-Schichtfolge, insbesondere mit Gold/Blau-Farbwechsel in Auflicht/ Durchlicht-Betrachtung);
• Heißsiegellackgrundierung (optional);
• Heißsiegellack (zum Kunststofffolienformteil gerichtet).

Another covering film which can be used for the tablet packaging according to the invention can have, for example, the following multilayer structure:

• Primer layer (optional);
• a paper layer;
• Carrier substrate, for example polypropylene, which is optionally equipped with inorganic fillers;
• semitransparent functional layer (eg Al / SiO ₂ / Al layer sequence or Ag / SiO ₂ / Ag layer sequence, in particular with gold / blue color change in reflected light / transmitted-light observation);
• Heat sealing lacquer primer (optional);
• Heat sealing lacquer (directed to the plastic film molding).

In the example above, the cover film contains, as a supporting layer, an additional paper layer in its multilayer structure. The additional paper layer gives the cover additional strength. The order of the layers in the above multi-layer structure can be varied, e.g. For example, the semitransparent functional layer may be present between the paper layer and the carrier substrate. For improved visibility of reflected light / transmitted light color change, the paper may be made transparent (e.g., by prior treatment with chemical reagents such as sulfuric acid). Alternatively or additionally, the paper may be partially recessed, e.g. by punching or laser cutting. Even deckle holes or watermarks (each available, for example, by means of roundsheet paper making) may also be provided in the paper layer as additional tamper-evident means.

• Primerschicht (optional);
• eine opake Schicht, insbesondere eine Druckschicht oder eine Metallisierung, mit Aussparungen in Form von Mustern, Zeichen oder einer Codierung;
• Trägersubstrat, z.B. Polypropylen, das ggf. mit anorganischen Füllstoffen ausgestattet ist;
• semitransparente Funktionsschicht (z.B. Al/SiO₂/Al-Schichtfolge oder Ag/SiO₂/Ag-Schichtfolge, insbesondere mit Gold/Blau-Farbwechsel in Auflicht/ Durchlicht-Betrachtung);
• Heißsiegellackgrundierung (optional);
• Heißsiegellack (zum Kunststofffolienformteil gerichtet).

Another covering film which can be used for the tablet packaging according to the invention can have, for example, the following multilayer structure:

• Primer layer (optional);
• an opaque layer, in particular a print layer or a metallization, with recesses in the form of patterns, characters or an encoding;
• Carrier substrate, for example polypropylene, which is optionally equipped with inorganic fillers;
• semitransparent functional layer (eg Al / SiO ₂ / Al layer sequence or Ag / SiO ₂ / Ag layer sequence, in particular with gold / blue color change in reflected light / transmitted-light observation);
• Heat sealing lacquer primer (optional);
• Heat sealing lacquer (directed to the plastic film molding).

The order of the above layers may be varied, if necessary. Thus, the semitransparent functional layer may e.g. be present between the opaque layer and the carrier substrate. Or the opaque layer may be present between the carrier substrate and the semitransparent functional layer.

Further embodiments and advantages of the invention are explained below with reference to the schematically greatly simplified figures, in the representation of a scale and proportionate reproduction has been omitted in order to increase the clarity.

Figuren 1 bis 4

eine erfindungsgemäße Verpackung gemäß einem ersten Ausführungsbeispiel;

Figuren 5 bis 8

eine erfindungsgemäße Verpackung gemäß einem zweiten Ausführungsbeispiel;

Figuren 9 bis 13

eine erfindungsgemäße Verpackung gemäß einem dritten Ausführungsbeispiel;

Figuren 14 bis 18

eine erfindungsgemäße Verpackung gemäß einem vierten Ausführungsbeispiel.

Show it:

FIGS. 1 to 4

a packaging according to the invention according to a first embodiment;

FIGS. 5 to 8

a packaging according to the invention according to a second embodiment;

FIGS. 9 to 13

a packaging according to the invention according to a third embodiment;

FIGS. 14 to 18

a packaging according to the invention according to a fourth embodiment.

FIGS. 1 to 4 illustrate the operation of a package according to the invention according to a first embodiment. The packaging is described in the present example on the basis of a tablet package.

• Primerschicht (zum Betrachter hin gerichtet);
• Trägersubstrat (Polypropylen);
• semitransparente Funktionsschicht (20nm Ag / 240nm SiO₂ / 20 nm Ag) mit Gold/Blau-Farbwechsel in Auflicht/Durchlicht-Betrachtung;
• Heißsiegellackgrundierung;
• Heißsiegellack (zum Kunststofffolienformteil 2 gerichtet).

FIG. 1 shows a tablet package 1, which comprises an opaque-white, for example made of PVC plastic film molding 2 and a cover 3. The block arrow 4 symbolizes the viewing of the tablet package 1 from the front, the block arrow 5 symbolizes the viewing of the tablet package 1 from the back. The cover film 3 has the following structure:

• Primer layer (directed towards the viewer);
• Carrier substrate (polypropylene);
• semi-transparent functional layer (20 nm Ag / 240 nm SiO _2/20 nm Ag) with gold / blue color change in incident light / transmitted light observation;
• Heat sealing lacquer primer;
• Heat sealing lacquer (directed towards the plastic film molding 2).

FIG. 2 shows the front of the tablet package 1. The viewer perceives the opaque white plastic film molding 2 in a uniform, white color. The reference numeral 6 in dashed form are the bubbles (or cavities or depressions) in the plastic film molding 2 indicated. With the reference number 7 possibly existing perforations are shown. From the tablet package 1 already nine tablets were taken by the consumer. Thus, only three tablets are present, which are present in the cavities 8, 9 and 10 and are not visible to the viewer as a result of the opaque-white Kunststoffolienformteils 2.

In the example shown, the covering film 3 is partially severed in the area of the removed tablets, but is still essentially present.

FIG. 3 shows the back of the tablet package 1 (ie the cover 3) when viewed in incident light. The viewer perceives the covering film 3 in the form of a homogeneous, gold-colored metallization.

FIG. 4 shows the back of the tablet package 1 (ie the cover 3) when viewed in transmitted light. The viewer perceives the three remaining tablets in cavities 8, 9 and 10 three-dimensionally in dark gold. The remaining part of the cover 3 appears to the viewer in bright gold, which has a bluish color component.

FIGS. 5 to 8 illustrate the operation of a package according to the invention according to a second embodiment. The packaging is described in the present example on the basis of a tablet package.

• Primerschicht (zum Betrachter hin gerichtet);
• Trägersubstrat (Polypropylen);
• semitransparente Funktionsschicht (20nm Ag / 240nm SiO₂ / 20 nm Ag) mit Gold/Blau-Farbwechsel in Auflicht/Durchlicht-Betrachtung;
• Heißsiegellackgrundierung;
• Heißsiegellack (zum Kunststofffolienformteil 12 gerichtet).

FIG. 5 shows a tablet package 11, which comprises a transparent plastic film molding 12 and a cover sheet 13. The block arrow 14 symbolizes the consideration of the tablet package 11 of the Front side, the block arrow 15 symbolizes the viewing of the tablet package 11 from the back. The cover sheet 13 has the following structure:

• Primer layer (directed towards the viewer);
• Carrier substrate (polypropylene);
• semi-transparent functional layer (20 nm Ag / 240 nm SiO _2/20 nm Ag) with gold / blue color change in incident light / transmitted light observation;
• Heat sealing lacquer primer;
• Heat sealing lacquer (directed towards the plastic film molding 12).

FIG. 6 shows the front side of the tablet package 11. The viewer sees the three still present in the tablet package tablets 16, 17 and 18. All other tablets have already been removed by the consumer from the tablet package, the cover sheet 13 although cut through in the area of the removed tablets, essentially but still exists. The observer perceives the covering film 13 through the transparent plastic film molding 12 as a background to the tablets 16, 17 and 18 in the form of a homogeneous, gold-colored metallization.

FIG. 7 shows the back side of the tablet package 11 (ie the cover film 13) when viewed in incident light. The viewer perceives the cover film 13 in the form of a homogeneous, gold-colored metallization.

FIG. 8 shows the back of the tablet package 11 (ie, the cover sheet 13) when viewed in transmitted light. The viewer perceives the three remaining tablets 16, 17 and 18 three-dimensional gold metallic. The remaining part of the cover sheet 13 appears to the viewer in bright blue, the shape and the cavities of the plastic film molding 12 are three-dimensional clearly visible.

FIGS. 9 to 13 illustrate the operation of a package according to the invention according to a third embodiment. The packaging is described in the present example on the basis of a tablet package.

• Primerschicht (zum Betrachter hin gerichtet);
• opake, goldfarbene Metallisierung mit Aussparungen (siehe die in der Figur 11 gezeigte Metallisierung 27 mit Aussparungen in Form der im Kunststofffolienformteil 20 enthaltenen Kavitäten);
• Trägersubstrat (Polypropylen);
• semitransparente Funktionsschicht (20nm Ag / 240nm SiO₂ / 20 nm Ag) mit Gold/Blau-Farbwechsel in Auflicht/Durchlicht-Betrachtung;
• Heißsiegellackgrundierung;
• Heißsiegellack (zum Kunststofffolienformteil 20 gerichtet).

FIG. 9 shows a tablet package 19 comprising a transparent plastic film molding 20 and a cover 21. The block arrow 22 symbolizes the viewing of the tablet package 19 from the front, the block arrow 23 symbolizes the viewing of the tablet package 19 from the back. The cover film 21 has the following structure:

• Primer layer (directed towards the viewer);
• Opaque, gold-colored metallization with recesses (see the in the FIG. 11 shown metallization 27 with recesses in the form of the cavities contained in the plastic film molding 20);
• Carrier substrate (polypropylene);
• semi-transparent functional layer (20 nm Ag / 240 nm SiO _2/20 nm Ag) with gold / blue color change in incident light / transmitted light observation;
• Heat sealing lacquer primer;
• Heat sealing lacquer (directed to the plastic film molding 20).

FIG. 10 shows the front of the tablet package 19. The viewer sees the three still present in the tablet packaging tablets 24, 25 and 26. All other tablets have already been removed by the consumer from the tablet package, the cover 21 in the field of Although separated tablets, but in essence is still present. The viewer perceives the cover film 21 through the transparent plastic film molding 20 as a background to the tablets 24, 25 and 26 in the form of a homogeneous, gold-colored metallization.

FIG. 12 shows the back of the tablet package 19 (ie, the cover sheet 21) when viewed in incident light. The viewer perceives the covering film 21 in the form of a homogeneous, gold-colored metallization.

FIG. 13 shows the back of the tablet package 19 (ie, the cover sheet 21) when viewed in transmitted light. Due to the additional presence of the opaque, gold-colored metallization 27 according to the FIG. 11 Within the layer structure of the covering film 21, the observer only perceives the region of the tablet packaging 19 where tablets have already been taken out, in bright blue, wherein the shape and the cavities of the plastic film molding 20 are clearly recognizable in three dimensions. The rest of the cover film 21 appears to the viewer homogeneous in the form of a golden, metallic surface.

FIGS. 14 to 18 illustrate the operation of a package according to the invention according to a fourth embodiment. The packaging is described in the present example on the basis of a tablet package.

• Primerschicht (zum Betrachter hin gerichtet);
• opake, goldfarbene Metallisierung mit Aussparungen (sogenannte Negativschrift; siehe die in der Figur 16 gezeigte Metallisierung 37 mit Aussparungen in Form der Großbuchstaben "TEXTTEXTTEXTTEXT");
• Trägersubstrat (Polypropylen);
• semitransparente Funktionsschicht (20nm Ag / 240nm SiO₂ / 20 nm Ag) mit Gold/Blau-Farbwechsel in Auflicht/Durchlicht-Betrachtung;
• Heißsiegellackgrundierung;
• Heißsiegellack (zum Kunststofffolienformteil 29 gerichtet).

FIG. 14 shows a tablet package 28 comprising a transparent plastic film molding 29 and a cover 30. The block arrow 32 symbolizes the consideration of the tablet package 28 of the Front side, the block arrow 33 symbolizes the viewing of the tablet package 28 from the back. The cover film 30 has the following structure:

• Primer layer (directed towards the viewer);
• opaque, gold-colored metallization with recesses (so-called negative writing, see the in the FIG. 16 shown metallization 37 with recesses in the form of the capital letters "TEXTTEXTTEXTTEXT");
• Carrier substrate (polypropylene);
• semi-transparent functional layer (20 nm Ag / 240 nm SiO _2/20 nm Ag) with gold / blue color change in incident light / transmitted light observation;
• Heat sealing lacquer primer;
• Heat sealing lacquer (directed to the plastic film molding 29).

FIG. 15 shows the front side of the tablet package 28. The viewer sees the three still present in the tablet packaging tablets 34, 35 and 36. All other tablets have already been removed by the consumer from the tablet package, the cover sheet 30 although cut through in the area of the removed tablets, essentially but still exists. The viewer perceives the cover film 30 through the transparent plastic film molding 29 as a background to the tablets 34, 35 and 36 in the form of a homogeneous gold-colored metallization.

FIG. 17 shows the back of the tablet package 28 (ie, the cover film 30) when viewed in incident light. The viewer perceives the cover film 30 in the form of a homogeneous, gold-colored metallization.

FIG. 18 shows the back of the tablet package 28 (ie, the cover sheet 30) when viewed in transmitted light. Due to the additional presence of the opaque, gold-colored metallization 37 with recesses (so-called negative writing) according to the FIG. 16 Within the layer structure of the covering film 30, the observer only perceives the area of the tablet packaging 28, where tablets have already been taken, in light blue in the form of the letters "EX". The rest of the cover film 30 appears to the viewer homogeneous in the form of a golden, metallic surface.

• Primerschicht (zum Betrachter hin gerichtet);
• gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind (die Metallpigmente beruhen auf einem Metall, das vorzugsweise von der Gruppe bestehend aus Aluminium, Edelstahl, Nichrome, Gold, Silber, Platin und Kupfer gewählt ist; das Metall ist insbesondere bevorzugt Aluminium, wobei der mittlere Teilchendurchmesser bevorzugt in einem Bereich von 8 bis 15 µm, weiter bevorzugt in einem Bereich von 9 bis 10 µm liegt, gemessen mit einem Coulter LS130 Laserdiffraktionsgranulometer; eine solche Druckfarbe ermöglicht die Bereitstellung einer "silbernen" Spiegelschicht);
• Trägersubstrat (Polypropylen);
• blaue Farbschicht;
• gelb eingefärbte, "silberne" Spiegelschicht, erhältlich mittels gelb eingefärbter Metallpigmente, die aus der WO 2005/051675 A2 bekannt sind;
• Heißsiegellackgrundierung;
• Heißsiegellack (zum Kunststofffolienformteil gerichtet).

A fifth embodiment (not shown in the figures) is similar to the above second embodiment. The cover foil with gold / blue color change in reflected light / transmitted-light observation has the following structure:

• Primer layer (directed towards the viewer);
• yellow-colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, from the WO 2005/051675 A2 The metal pigments are based on a metal, which is preferably selected from the group consisting of aluminum, stainless steel, nichrome, gold, silver, platinum and copper, the metal is particularly preferably aluminum, wherein the average particle diameter is preferably in a range of 8 to 15 μm, more preferably in a range of 9 to 10 μm, measured with a Coulter LS130 laser diffraction granulometer; such ink enables the provision of a "silver" mirror layer;
• Carrier substrate (polypropylene);
• blue color layer;
• yellow-colored, "silver" mirror layer, obtainable by means of yellow-colored metal pigments, from the WO 2005/051675 A2 are known;
• Heat sealing lacquer primer;
• Heat sealing lacquer (directed to the plastic film molding).

• Primerschicht (zum Betrachter hin gerichtet);
• gelbe Farbschicht;
• semitransparente metallische Schicht, z.B. Al;
• Trägersubstrat (Polypropylen);
• blaue Farbschicht;
• semitransparente metallische Schicht, z.B. Al,
• gelbe Farbschicht;
• Heißsiegellackgrundierung;
• Heißsiegellack (zum Kunststofffolienformteil gerichtet

A sixth embodiment (not shown in the figures) is similar to the above second embodiment. The cover foil with gold / blue color change in reflected light / transmitted-light observation has the following structure:

• Primer layer (directed towards the viewer);
• yellow color layer;
• semitransparent metallic layer, eg Al;
• Carrier substrate (polypropylene);
• blue color layer;
• semitransparent metallic layer, eg Al,
• yellow color layer;
• Heat sealing lacquer primer;
• Heat sealing lacquer (directed to the plastic film molding)

• Primerschicht (zum Betrachter hin gerichtet);
• Trägersubstrat (Polypropylen);
• semitransparente Funktionsschicht (z.B. Ag/SiO₂/Ag-Aufbau oder Al/SiO₂/Al-Aufbau) mit Gold/Blau-Farbwechsel in Auflicht/Durchlicht-Betrachtung;
• Heißsiegellackgrundierung;
• Heißsiegellack (zum Kunststofffolienformteil gerichtet).

A seventh embodiment (not shown in the figures) is similar to the above second embodiment. The cover foil with gold / blue color change in reflected light / transmitted-light observation has the following structure:

• Primer layer (directed towards the viewer);
• Carrier substrate (polypropylene);
• semitransparent functional layer (eg Ag / SiO ₂ / Ag structure or Al / SiO ₂ / Al structure) with gold / blue color change in incident light / transmitted-light observation;
• Heat sealing lacquer primer;
• Heat sealing lacquer (directed to the plastic film molding).

The above cover sheet was applied by heat sealing to a plastic sheet molding in the wells of which tablets were contained, to thereby prepare a tablet package. After irradiation with an Nd: YAG laser, a two-dimensional barcode was introduced into the covering film of the tablet packaging. The laser radiation causes a change in the semitransparent functional layer (probably an ablation or vaporization of the metal), so that in the semitransparent functional layer a visible in the reflected light and transmitted light for the viewer transparent mark in the form of a two-dimensional barcode is generated.

In particular, the primer layer used in the above embodiments may be a dye accepting layer suitable for printing with ink. In this way, the printability of the masking sheet with writing (e.g., manufacturer and brand name of a drug) can be further improved.

The heat-sealing lacquer primer used in the above embodiments is optional.

The polypropylene-based supporting substrate used in the above embodiments may contain inorganic fillers to improve the press-through property of the cover sheet. However, the carrier substrate may also be based on other materials, for example cycloolefin copolymer (COC) or cycloolefin polymer (COP), or on films containing at least one layer of cycloolefin copolymer (COC) or cycloolefin polymer (COP), eg films with the construction COC / PE / COC or COC / PP / COC or COC / PE-LLD / COC or a film with a COC core layer (For example, the following layer sequence: polymeric thermal protection layer (preferably selected from COC, COP, PP, PA or PET) - COC core layer - polymeric heat seal layer), described in the WO 2009/000403 A1 or in the WO 2010/139409 A1 , A cover film with excellent transparency, printability and metallizability is based, for example, on a 30 μm thick carrier substrate with COC / PP / COC three-layer structure, wherein the COC material used is, in particular, the commercial type TOPAS® 6013F-04, in view of its high rigidity.

Claims (15)

1. A packaging (1, 11, 19, 28) in the form of a blister for pharmaceutical products, comprising a plastic foil molded part (2, 12, 20, 29) and a cover foil (3, 13, 21, 30) in the form of a push-through foil, wherein the plastic foil molded part (2 12, 20, 29) defines the front side of the packaging (1, 11, 19, 28) and the cover foil (3, 13, 21, 30) defines the back side of the packaging (1, 11, 19, 28) and the cover foil (3, 13, 21, 30) is based on a transparent or semitransparent carrier substrate provided with a semitransparent function layer, wherein the semitransparent function layer is constituted such that the cover foil (3, 13, 21, 30) has a first, visually recognizable, homogenous color upon viewing in incident light and has a second, visually recognizable color upon viewing in transmitted light.
2. The packaging (1, 11, 19, 28) according to claim 1, wherein the packaging (1, 11, 19, 28) is constituted such that a packaged object (16, 17, 18, 24, 25, 26, 34, 35, 36), e.g. a tablet, is not recognizable upon viewing the back side of the packaging (1, 11, 19, 28) in incident light and is recognizable upon viewing the back side of the packaging (1, 11, 19, 28) in transmitted light in the form of a motif formed by the first, visually recognizable color and the second, visually recognizable color.
3. The packaging (1, 11, 19, 28) according to claim 1 or 2, wherein the semitransparent function layer has a multi-layer structure with two semitransparent metallic layers and a dielectric layer arranged between the two semitransparent metallic layers.
4. The packaging (1, 11, 19, 28) according to claim 3, wherein the two semitransparent metallic layers are formed independently of each other from a metal and the metal is respectively chosen from the group consisting of Al, Ag, Ni, Cr, Cu, Au and an alloy of one or several of the hereinabove mentioned elements and the dielectric layer is an SiO₂ layer, a ZnO layer, an Al₂O₃ layer, a TiO₂ layer, a layer made of a nitride or oxynitride of one of the elements Si, Zn, Al or Ti, or an MgF₂ layer, or a nitrocellulose layer obtainable, e.g., by printing technology.
5. The packaging (1, 11, 19, 28) according to claim 4, wherein the two semitransparent metallic layers are chosen independently of each other from Al or Ag and the dielectric layer is an SiO₂ layer.
6. The packaging (1, 11, 19, 28) according to any of claims 3 to 5, wherein the cover foil appears golden upon viewing in incident light and has a blue color tone upon viewing in transmitted light.
7. The packaging (1, 11, 19, 28) according to any of claims 1 or 2, wherein the semitransparent function layer is obtainable by printing technology by means of an effect pigment composition.
8. The packaging (1, 11, 19, 28) according to any of claims 1 or 2, wherein the semitransparent function layer is a layer system with two semitransparent metallic layers and an intermediate color layer.
9. The packaging (1, 11, 19, 28) according to claim 8, wherein the two semitransparent metallic layers respectively are an Al layer.
10. The packaging (1, 11, 19, 28) according to claim 8 or 9, wherein the two semitransparent metallic layers are respectively additionally coated with a further color layer at the outer side, in particular in a complementary color to the color layer arranged between the metallic layers.
11. The packaging (1, 11, 19, 28) according to any of claims 1 to 10, wherein the cover foil (3, 13, 21, 30) has visually recognizable markings in the form of patterns, characters or a coding, obtainable by irradiation with laser radiation, the visually recognizable markings being produced in the semitransparent function layer.
12. The packaging (1, 11, 19, 28) according to any of claims 1 to 11, wherein the cover foil (3, 13, 21, 30) additionally has an opaque layer (27, 37), in particular a printed layer or a metallization, with gaps in the form of patterns, characters or a coding.
13. The packaging (1, 11, 19, 28) according to any of claims 1 to 12, wherein the plastic foil molded part (2, 12, 20, 29) is opaque, opaque-white or transparent and is preferably transparent.
14. The packaging (1, 11, 19, 28) according to any of claims 1 to 13, wherein the packaging (1, 11, 19, 28) is a tablet packaging.
15. The packaging (1, 11, 19, 28) according to any of claims 1 to 14, wherein the carrier substrate is chosen from the following materials:

    - polypropylene which has an inorganic filler;

    - cycloolefin copolymer (COC) or cycloolefin polymer (COP), or a film which contains at least one layer of cycloolefin copolymer (COC) or cycloolefin polymer (COP);

    - a film from oriented polyethylene terephthalate (OPET) which with a polyethylene layer or a polypropylene layer is combined into a laminate, wherein the laminate has cutting grooves or notches;

    - uniaxially oriented polypropylene film irradiated with ionising radiation;

    - porous plastic film, preferably polyethylene terephthalate film or polypropylene film, which for covering the small pores is coated with a molten resin, preferably olefin resin, e.g. a polyethylene resin or a polypropylene resin;

    - polymer phase containing polyolefin (A), in which a hydrocarbon resin component (B) is contained in dissolved form, wherein the hydrocarbon resin component (B) is different from the polyolefin (A), comprises cyclic side groups at the polymer chain and is contained with a portion of at least 3 wt-% in the overall mass in the carrier substrate, wherein the average molecular weight of the hydrocarbon resin component (B) is smaller or equal to 10 000, wherein the polyolefin (A) is preferably polyethylene, polypropylene or a copolymer or terpolymer of ethylene and/or propylene and the component (B) is in particular an amorphous polymer.

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