EP3349768A4 - Antikörper zur erzeugung antiinflammatorischer makrophagen und entsprechende verwendungen - Google Patents
Antikörper zur erzeugung antiinflammatorischer makrophagen und entsprechende verwendungen Download PDFInfo
- Publication number
- EP3349768A4 EP3349768A4 EP16847105.0A EP16847105A EP3349768A4 EP 3349768 A4 EP3349768 A4 EP 3349768A4 EP 16847105 A EP16847105 A EP 16847105A EP 3349768 A4 EP3349768 A4 EP 3349768A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antibodies
- generating anti
- related uses
- inflammatory macrophage
- macrophage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 210000002540 macrophage Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562218785P | 2015-09-15 | 2015-09-15 | |
PCT/US2016/051290 WO2017048629A1 (en) | 2015-09-15 | 2016-09-12 | Antibodies for generating anti-inflammatory macrophage and related uses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3349768A1 EP3349768A1 (de) | 2018-07-25 |
EP3349768A4 true EP3349768A4 (de) | 2019-01-23 |
Family
ID=58289788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16847105.0A Withdrawn EP3349768A4 (de) | 2015-09-15 | 2016-09-12 | Antikörper zur erzeugung antiinflammatorischer makrophagen und entsprechende verwendungen |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP3349768A4 (de) |
AU (1) | AU2016324021A1 (de) |
WO (1) | WO2017048629A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023146860A1 (en) * | 2022-01-28 | 2023-08-03 | The George Washington University | Compositions for and methods of treating a subject having inflammation |
CN116445407B (zh) * | 2023-06-16 | 2023-09-08 | 广州正源生物技术有限公司 | 一种胎盘巨噬细胞的提取和扩增培养方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060272041A1 (en) * | 2001-09-24 | 2006-11-30 | Wisotzkey Robert G | Cathepsin G (CTSG) Disruptions, Compositions and Methods Relating Thereto |
EP1470159B1 (de) * | 2001-12-04 | 2013-08-07 | Dana-Farber Cancer Institute, Inc. | Antikörper gegen latente membranproteine und verwendungen davon |
CA2777691C (en) * | 2009-10-16 | 2018-02-27 | Biorealites | Monoclonal antibodies to progastrin and their uses |
WO2012024309A2 (en) * | 2010-08-18 | 2012-02-23 | Cedars-Sinai Medical Center | Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer |
CA2835603A1 (en) * | 2011-05-09 | 2012-11-15 | Perseus Proteomics Inc. | Antibody capable of specifically recognizing transferrin receptor |
-
2016
- 2016-09-12 AU AU2016324021A patent/AU2016324021A1/en not_active Abandoned
- 2016-09-12 EP EP16847105.0A patent/EP3349768A4/de not_active Withdrawn
- 2016-09-12 WO PCT/US2016/051290 patent/WO2017048629A1/en active Application Filing
Non-Patent Citations (8)
Title |
---|
B. KORKMAZ ET AL: "Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases", PHARMACOLOGICAL REVIEWS, vol. 62, no. 4, 15 November 2010 (2010-11-15), US, pages 726 - 759, XP055535637, ISSN: 0031-6997, DOI: 10.1124/pr.110.002733 * |
DAVID G LOMAS ET AL: "The Control of Neutrophil Chemotaxis by Inhibitors of", J. BIOL. CHEM., 1 January 1995 (1995-01-01), pages 23437 - 23443, XP055535631, Retrieved from the Internet <URL:http://www.jbc.org/content/270/40/23437.full.pdf> [retrieved on 20181217] * |
KEITH M SKUBITZ ET AL: "Preparation and Characterization of Monoclonal Antibodies to Human Neutrophil Cathepsin G, Lactoferrin, Eosinophil Peroxidase, and Eosinophil Major Basic Protein", JOURNAL OF LEUKOCYTE BIOLOGY, 1 January 1989 (1989-01-01), pages 109 - 118, XP055535628, Retrieved from the Internet <URL:https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1002/jlb.46.2.109> [retrieved on 20181217] * |
NADINE JETTEN ET AL: "Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo", ANGIOGENESIS, vol. 17, no. 1, 8 September 2013 (2013-09-08), NL, pages 109 - 118, XP055535574, ISSN: 0969-6970, DOI: 10.1007/s10456-013-9381-6 * |
NAUDER FARADAY ET AL: "Cathepsin G-Dependent Modulation of Platelet Thrombus Formation In Vivo by Blood Neutrophils", PLOS ONE, vol. 8, no. 8, 5 August 2013 (2013-08-05), pages e71447, XP055535633, DOI: 10.1371/journal.pone.0071447 * |
PAOLO CONROTTO ET AL: "Identification of new accessible tumor antigens in human colon cancer by ex vivo protein biotinylation and comnparative mass spectrometry analysis", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, US, vol. 123, no. 12, 15 December 2008 (2008-12-15), pages 2856 - 2864, XP002663352, ISSN: 0020-7136, [retrieved on 20080916], DOI: 10.1002/IJC.23861 * |
RICHARD A. LERNER ET AL: "Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates", QUARTERLY REVIEWS OF BIOPHYSICS., vol. 48, no. 04, 16 July 2015 (2015-07-16), pages 389 - 394, XP055238228, ISSN: 0033-5835, DOI: 10.1017/S0033583515000049 * |
See also references of WO2017048629A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2016324021A1 (en) | 2018-04-12 |
WO2017048629A1 (en) | 2017-03-23 |
EP3349768A1 (de) | 2018-07-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3498840A4 (de) | Anti-lag-3-antikörper | |
EP3247435A4 (de) | Ultraschall-verdampfungselement | |
EP3334757A4 (de) | Anti-tigit-antikörper | |
EP3297671A4 (de) | Anti-ror1-antikörper | |
EP3354729A4 (de) | Anti-garp-antikörper | |
EP3336220A4 (de) | Gasgenerator | |
EP3318754A4 (de) | Schuberzeugungsvorrichtung vom magnus-typ | |
EP3229838A4 (de) | Anti-c10orf54-antikörper und verwendungen davon | |
EP3315035A4 (de) | Zerstäubungseinheit | |
EP3283517A4 (de) | Anti-pacap-antikörper und verwendungen davon | |
EP3267139A4 (de) | Turbulenzerzeugungsvorrichtung | |
EP3492591A4 (de) | Anti-b7-h4-antikörper | |
EP3252074A4 (de) | Anti-alk2-antikörper | |
EP3192518A4 (de) | Entzündungshemmender wirkstoff | |
EP3349794A4 (de) | Anti-cd115-antikörper | |
EP3433720A4 (de) | Willkürliche ansichterzeugung | |
EP3381941A4 (de) | Anti-epha4-antikörper | |
EP3307030A4 (de) | Plasmaerzeugungsvorrichtung | |
EP3366526A4 (de) | Gasgenerator | |
EP3369630A4 (de) | Gasgenerator | |
EP3423364A4 (de) | Karton mit erweiterungsfunktionen | |
EP3166609A4 (de) | Gegen ral-gtpasen gerichtete verbindungen gegen krebs und verfahren zur verwendung davon | |
EP3336185A4 (de) | Antikörper | |
EP3194035A4 (de) | Wellenerzeugungssysteme | |
AU2016349786B2 (en) | Anti-CD3-folate conjugates and their uses |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20180326 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20190104 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 35/12 20150101ALI20181220BHEP Ipc: C12N 5/0786 20100101ALI20181220BHEP Ipc: C07K 16/40 20060101AFI20181220BHEP Ipc: A61K 49/16 20060101ALI20181220BHEP Ipc: A61K 35/15 20150101ALI20181220BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20190802 |