EP3340974A4 - Verfahren zur behandlung von erkrankungen - Google Patents
Verfahren zur behandlung von erkrankungen Download PDFInfo
- Publication number
- EP3340974A4 EP3340974A4 EP16842687.2A EP16842687A EP3340974A4 EP 3340974 A4 EP3340974 A4 EP 3340974A4 EP 16842687 A EP16842687 A EP 16842687A EP 3340974 A4 EP3340974 A4 EP 3340974A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- diseases
- treatment
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562211296P | 2015-08-28 | 2015-08-28 | |
PCT/US2016/048999 WO2017040287A1 (en) | 2015-08-28 | 2016-08-26 | Methods for treatment of diseases |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3340974A1 EP3340974A1 (de) | 2018-07-04 |
EP3340974A4 true EP3340974A4 (de) | 2019-03-13 |
EP3340974B1 EP3340974B1 (de) | 2021-04-28 |
Family
ID=58188034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16842687.2A Active EP3340974B1 (de) | 2015-08-28 | 2016-08-26 | Peptide zur behandlung des myokardinfarkts |
Country Status (10)
Country | Link |
---|---|
US (2) | US11020462B2 (de) |
EP (1) | EP3340974B1 (de) |
JP (1) | JP6929272B2 (de) |
CN (4) | CN111909258B (de) |
AU (1) | AU2016317726B2 (de) |
BR (1) | BR112018003928A2 (de) |
CA (1) | CA2996975C (de) |
HK (1) | HK1258994A1 (de) |
IL (1) | IL257764B (de) |
WO (1) | WO2017040287A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015006228A1 (en) | 2013-07-08 | 2015-01-15 | The University Of Utah Research Foundation | Methods for treatment of and prophylaxis against inflammatory disorders |
WO2017040287A1 (en) | 2015-08-28 | 2017-03-09 | Serpin Pharma, Llc | Methods for treatment of diseases |
JP2021518149A (ja) * | 2018-03-26 | 2021-08-02 | オリジンセル セラピューティクス カンパニー リミテッド | 免疫細胞増殖を促進する方法 |
CN114555103A (zh) * | 2019-06-03 | 2022-05-27 | 伊美诺路克斯国际公司 | 用于治疗疾病的天花疫苗和干细胞 |
US11779630B2 (en) | 2020-07-06 | 2023-10-10 | Serpin Pharma, Llc | Peptides and methods of using the same |
WO2023133078A2 (en) * | 2022-01-05 | 2023-07-13 | Serpin Pharma, Llc | Serpin peptides and methods of using the same |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011109768A2 (en) * | 2010-03-04 | 2011-09-09 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for modulating cardiac conditions |
WO2013106589A1 (en) * | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
WO2013106273A2 (en) * | 2012-01-09 | 2013-07-18 | Serpin Pharma, Llc | Peptides and methods of using same |
Family Cites Families (45)
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IT1190891B (it) | 1982-06-24 | 1988-02-24 | Anic Spa | Metodo per la sintesi in fase solida di polipeptidi retroinvertiti |
US5910304A (en) | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
FI81498C (fi) | 1987-01-13 | 1990-11-12 | Biocon Oy | Kirurgiska material och instrument. |
US5580561A (en) | 1987-03-06 | 1996-12-03 | Cercek; Boris | Methods and pharmaceutical compositions for blocking suppression of immune defense mechanisms using an antibody, a factor, or an antisense peptide |
US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5981276A (en) | 1990-06-20 | 1999-11-09 | Dana-Farber Cancer Institute | Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof |
US5353535A (en) | 1990-11-05 | 1994-10-11 | Plumly George W | Floor type advertising apparatus |
US6261569B1 (en) | 1992-08-27 | 2001-07-17 | Deakin Research Limited | Retro-, inverso- and retro-inverso synthetic peptide analogues |
AU683022B2 (en) | 1992-09-10 | 1997-10-30 | Children's Medical Center Corporation | Biodegradable polymer matrices for sustained delivery of local anesthetic agents |
WO1994012649A2 (en) | 1992-12-03 | 1994-06-09 | Genzyme Corporation | Gene therapy for cystic fibrosis |
US5514653A (en) | 1994-09-09 | 1996-05-07 | Washington University | Method of blocking the SEC receptor |
US5665557A (en) | 1994-11-14 | 1997-09-09 | Systemix, Inc. | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof |
AU7435296A (en) | 1995-10-16 | 1997-05-07 | Dana-Farber Cancer Institute | Novel expression vectors and methods of use |
US6036949A (en) | 1998-03-05 | 2000-03-14 | Amarillo Biosciences, Inc. | Treatment of fibromyalgia with low doses of interferon |
ATE269412T1 (de) | 1998-04-24 | 2004-07-15 | Univ Florida | Rekombinanter adeno-assoziierter viraler vektor, der alpha-1 antitrypsin kodiert, zur gentherapie |
US20100210528A1 (en) | 1999-03-05 | 2010-08-19 | Leland Shapiro | Compositions, methods and uses for inhibition and/or treatment of influenza infection |
US20070003518A1 (en) | 2002-04-19 | 2007-01-04 | Atkinson Mark A | Raav vector-based compositions and methods for the prevention and treatment of mammalian diseases |
EP3192872A1 (de) | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitoren der serinproteaseaktivität und deren verwendung in verfahren und zusammensetzungen zur behandlung bakterieller infektionen |
CA2552758A1 (en) * | 2004-01-13 | 2005-08-04 | Vasogenix Pharmaceuticals, Inc. | Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same |
EP2093569A3 (de) | 2004-05-21 | 2009-11-11 | The Institute for Systems Biology | Zusammensetzungen und Verfahren zur Quantifizierung von Serum-Glycoproteinen |
US8715649B2 (en) | 2005-06-07 | 2014-05-06 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity |
BRPI0621081A2 (pt) | 2005-12-23 | 2011-11-29 | Vital Health Sciences Pty Ltd | método de modulação de uma ou mais citocinas imuno-reguladoras, uso de um ou mais derivados de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos, método de inibição de uma resposta inflamatória e/ou de estimulação de uma resposta anti-inflamatória, método de tratamento e/ou de profilaxia de distúbios imunológicos, distúrbios inflamatórios e/ou distúrbios proliferativos celulares, agente imuno-modulador, agente anti-inflamatório ou agente anti-cáncer e um ou mais derivado de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos |
EP1996215A2 (de) | 2006-02-28 | 2008-12-03 | Trustees Of Boston University | Stoffwechselregulatoren und ihre verwendungen |
US20080008694A1 (en) * | 2006-07-05 | 2008-01-10 | Elgebaly Salwa A | Methods to prevent and treat diseases |
US20100267052A1 (en) | 2006-09-01 | 2010-10-21 | American Type Culture Collection | Compositions and methods for diagnosis and treatment of type 2 diabetes |
US7951776B2 (en) | 2006-09-01 | 2011-05-31 | American Type Culture Collection | Methods for treatment of type 1 diabetes |
US8623830B2 (en) | 2006-09-12 | 2014-01-07 | Beth Israel Deaconess Medical Center, Inc. | Compositions containing α-1-antitrypsin and methods for use |
EA201000399A1 (ru) | 2007-08-30 | 2011-02-28 | Кьюрдм, Инк. | Композиции и способы использования проостровковых пептидов и их аналогов |
US8758761B2 (en) | 2007-09-30 | 2014-06-24 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
US7923253B2 (en) | 2007-11-05 | 2011-04-12 | Battelle Memorial Institute | Method for identifying type I diabetes mellitus in humans |
WO2011126882A2 (en) | 2010-03-30 | 2011-10-13 | American Type Culture Collection | Therapeutic peptides and their derivatives and therapeutic uses thereof |
US9005615B2 (en) * | 2010-05-06 | 2015-04-14 | The Feinstein Institute For Medical Research | Methods for treatment of inflammatory diseases |
WO2014197524A2 (en) * | 2013-06-06 | 2014-12-11 | Serpin Pharma, Llc | Peptide therapy for treatment of alpha-1 antitrypsin deficiency and associated pathologies |
KR101523763B1 (ko) * | 2013-06-19 | 2015-06-01 | 한국원자력연구원 | 금속 표면 고착성 방사능 오염 산화막 제거를 위한 산화 제염제 및 이를 이용한 산화 제염방법 |
KR20160146242A (ko) | 2015-06-12 | 2016-12-21 | 현대자동차주식회사 | 터보차저 엔진의 재순환 밸브 구동 장치 및 방법 |
WO2017040287A1 (en) | 2015-08-28 | 2017-03-09 | Serpin Pharma, Llc | Methods for treatment of diseases |
-
2016
- 2016-08-26 WO PCT/US2016/048999 patent/WO2017040287A1/en active Application Filing
- 2016-08-26 CA CA2996975A patent/CA2996975C/en active Active
- 2016-08-26 BR BR112018003928A patent/BR112018003928A2/pt active Search and Examination
- 2016-08-26 AU AU2016317726A patent/AU2016317726B2/en active Active
- 2016-08-26 JP JP2018511128A patent/JP6929272B2/ja active Active
- 2016-08-26 CN CN202010764749.9A patent/CN111909258B/zh active Active
- 2016-08-26 CN CN202110597142.0A patent/CN113425837A/zh active Pending
- 2016-08-26 CN CN201680063220.6A patent/CN108366985B/zh active Active
- 2016-08-26 CN CN202110597016.5A patent/CN113429455A/zh active Pending
- 2016-08-26 US US15/755,693 patent/US11020462B2/en active Active
- 2016-08-26 EP EP16842687.2A patent/EP3340974B1/de active Active
-
2018
- 2018-02-27 IL IL257764A patent/IL257764B/en unknown
-
2019
- 2019-01-29 HK HK19101479.7A patent/HK1258994A1/zh unknown
-
2021
- 2021-03-29 US US17/215,738 patent/US20210369822A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011109768A2 (en) * | 2010-03-04 | 2011-09-09 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for modulating cardiac conditions |
WO2013106273A2 (en) * | 2012-01-09 | 2013-07-18 | Serpin Pharma, Llc | Peptides and methods of using same |
WO2013106589A1 (en) * | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
Non-Patent Citations (1)
Title |
---|
See also references of WO2017040287A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20210369822A1 (en) | 2021-12-02 |
WO2017040287A1 (en) | 2017-03-09 |
BR112018003928A2 (pt) | 2018-09-25 |
EP3340974B1 (de) | 2021-04-28 |
EP3340974A1 (de) | 2018-07-04 |
CN108366985B (zh) | 2021-06-18 |
AU2016317726A1 (en) | 2018-04-12 |
CN111909258A (zh) | 2020-11-10 |
CN108366985A (zh) | 2018-08-03 |
JP2018531221A (ja) | 2018-10-25 |
AU2016317726B2 (en) | 2022-05-26 |
CN113429455A (zh) | 2021-09-24 |
IL257764B (en) | 2022-06-01 |
CA2996975C (en) | 2022-02-15 |
HK1258994A1 (zh) | 2019-11-22 |
CA2996975A1 (en) | 2017-03-09 |
CN113425837A (zh) | 2021-09-24 |
JP6929272B2 (ja) | 2021-09-01 |
US20190328852A1 (en) | 2019-10-31 |
US11020462B2 (en) | 2021-06-01 |
CN111909258B (zh) | 2021-09-17 |
IL257764A (en) | 2018-04-30 |
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