EP3337815A4 - Zellpermeables socs3-rekombinantes protein und verwendungen davon - Google Patents

Zellpermeables socs3-rekombinantes protein und verwendungen davon Download PDF

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Publication number
EP3337815A4
EP3337815A4 EP16837265.4A EP16837265A EP3337815A4 EP 3337815 A4 EP3337815 A4 EP 3337815A4 EP 16837265 A EP16837265 A EP 16837265A EP 3337815 A4 EP3337815 A4 EP 3337815A4
Authority
EP
European Patent Office
Prior art keywords
permeable
cell
recombinant protein
socs3 recombinant
socs3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16837265.4A
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English (en)
French (fr)
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EP3337815A1 (de
EP3337815B1 (de
Inventor
Daewoong Jo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellivery Therapeutics Inc
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Cellivery Therapeutics Inc
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Publication of EP3337815A1 publication Critical patent/EP3337815A1/de
Publication of EP3337815A4 publication Critical patent/EP3337815A4/de
Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP16837265.4A 2015-08-18 2016-08-11 Zellpermeables socs3-rekombinantes protein und verwendungen davon Active EP3337815B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562206587P 2015-08-18 2015-08-18
PCT/KR2016/008831 WO2017030323A1 (en) 2015-08-18 2016-08-11 Cell-permeable (cp)-δsocs3 recombinant protein and uses thereof

Publications (3)

Publication Number Publication Date
EP3337815A1 EP3337815A1 (de) 2018-06-27
EP3337815A4 true EP3337815A4 (de) 2018-11-07
EP3337815B1 EP3337815B1 (de) 2020-12-16

Family

ID=58050909

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16837265.4A Active EP3337815B1 (de) 2015-08-18 2016-08-11 Zellpermeables socs3-rekombinantes protein und verwendungen davon

Country Status (3)

Country Link
US (2) US10323072B2 (de)
EP (1) EP3337815B1 (de)
WO (1) WO2017030323A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160060312A1 (en) 2014-08-27 2016-03-03 Cellivery Therapeutics, Inc. Development of Protein-Based Biotherapeutics That Penetrates Cell-Membrane and Induces Anti-Pancreatic Cancer Effect - Improved Cell-Permeable Suppressor of Cytokine Signaling (iCP-SOCS3) Proteins, Polynucleotides Encoding the Same, and Anti-Pancreatic Cancer Compositions Comprising the Same
US20170029798A1 (en) 2015-07-27 2017-02-02 Cellivery Therapeutics, Inc. Development of Improved Cell-Permeable (iCP) Parkin Recombinant Protein as a Protein-Based Anti-Neurodegenerative Agent for the Treatment of Parkinson's Disease-Associated Phenotypes by Utilizing BBB-Penetrating Protein Delivery System MITT, Enabled by Advanced Macromolecule Transduction Domain (aMTD)
EP3334755B1 (de) * 2015-08-10 2020-04-08 Cellivery Therapeutics, Inc. Verbessertes rekombinantes protein des zelldurchlässigen reprogrammierungsfaktors (icp-rf) und verwendung davon
EP3645557B1 (de) * 2017-06-28 2024-10-23 The Cleveland Clinic Foundation Behandlung von läsionen des nervensystems und neurodegenerativen erkrankungen sowie verwandten zuständen
TWI656172B (zh) 2017-09-18 2019-04-11 台燿科技股份有限公司 無溶劑之樹脂組合物及其應用
EP4208475A4 (de) * 2020-09-04 2024-10-16 Cellivery Therapeutics Inc Entwicklung eines zellpermeablen verkürzten rekombinanten socs3-sh2-domänenproteins (cp-sd) für mittel gegen adipositas

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005086800A2 (en) * 2004-03-04 2005-09-22 Vanderbilt University Cell-penetrating socs polypeptides that inhibit cytokine-induced signaling
WO2011113048A2 (en) * 2010-03-12 2011-09-15 Vanderbilt University Modulation of cytokine signaling
WO2012050402A2 (ko) * 2010-10-14 2012-04-19 주식회사 프로셀제약 세포투과성 parkin 재조합 단백질 및 이를 함유하는 퇴행성 뇌질환 치료용 약학적 조성물
WO2016028036A1 (en) * 2014-08-17 2016-02-25 Cellivery Therapeutics, Inc. Advanced macromolecule transduction domain (amtd) sequences for improvement of cell-permeability, polynucleotides encoding the same, method to identify the unique features of amtds comprising the same, method to develop the amtd sequences comprising the same
US20160060310A1 (en) * 2014-08-27 2016-03-03 Daewoong Jo Development of Protein-Based Biotherapeutics That Penetrates Cell-Membrane and Induces Anti-Hepatocellular Carcinoma Effect - Improved Cell-Permeable Suppressor of Cytokine Signaling (iCP-SOCS3) Proteins, Polynucleotides Encoding the Same, and Anti-Hepatocellular Carcinoma Compositions Comprising the Same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104622A1 (en) 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
EP1230267B1 (de) 1999-09-27 2006-03-29 Elan Corporation Membrantranslokierendes peptid als wirkstofftransportsystem
WO2003066801A2 (en) 2002-02-05 2003-08-14 Indian Institute Of Technology Method for specific integration of t7 rna polymerase gene in the chromosome of corynebacterial and the resultant corynebacteria-t7 promoter based shuttle vector system.
WO2003097671A1 (en) 2002-03-29 2003-11-27 Creagene Inc. Cytoplasmic transduction peptides and uses thereof
US6835810B2 (en) 2002-05-13 2004-12-28 Geneshuttle Biopharma, Inc. Fusion protein for use as vector
US7592144B2 (en) * 2005-03-17 2009-09-22 The Trustees Of Princeton University Bacterial ligand-binding sensor
CN101616928B (zh) 2007-01-29 2015-04-15 株式会社普罗赛尔制药 新型大分子转导域及其识别方法和用途
WO2009032148A1 (en) 2007-08-29 2009-03-12 Tufts University Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits
WO2009139599A2 (ko) 2008-05-16 2009-11-19 주식회사 프로셀제약 세포투과성 p27 재조합 단백질, 이를 코딩하는 폴리뉴클레오티드 및 이를 유효성분으로 함유하는 항암 조성물
NZ611176A (en) 2010-12-02 2015-07-31 Bionor Immuno As Peptide scaffold design
CA2834577A1 (en) 2011-05-23 2012-11-29 Phylogica Limited Method of determining, identifying or isolating cell-penetrating peptides
KR101258279B1 (ko) 2011-11-23 2013-04-25 주식회사 프로셀제약 세포 투과능을 개선한 개량형 신규 거대 분자 전달 도메인 개발 및 이의 이용방법
CN104039811B (zh) * 2011-11-23 2018-02-23 株式会社普罗赛尔制药 具有改善的细胞渗透性的新的大分子转导结构域的研发及其使用方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005086800A2 (en) * 2004-03-04 2005-09-22 Vanderbilt University Cell-penetrating socs polypeptides that inhibit cytokine-induced signaling
WO2011113048A2 (en) * 2010-03-12 2011-09-15 Vanderbilt University Modulation of cytokine signaling
WO2012050402A2 (ko) * 2010-10-14 2012-04-19 주식회사 프로셀제약 세포투과성 parkin 재조합 단백질 및 이를 함유하는 퇴행성 뇌질환 치료용 약학적 조성물
WO2016028036A1 (en) * 2014-08-17 2016-02-25 Cellivery Therapeutics, Inc. Advanced macromolecule transduction domain (amtd) sequences for improvement of cell-permeability, polynucleotides encoding the same, method to identify the unique features of amtds comprising the same, method to develop the amtd sequences comprising the same
US20160060310A1 (en) * 2014-08-27 2016-03-03 Daewoong Jo Development of Protein-Based Biotherapeutics That Penetrates Cell-Membrane and Induces Anti-Hepatocellular Carcinoma Effect - Improved Cell-Permeable Suppressor of Cytokine Signaling (iCP-SOCS3) Proteins, Polynucleotides Encoding the Same, and Anti-Hepatocellular Carcinoma Compositions Comprising the Same

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE Geneseq [online] 21 April 2016 (2016-04-21), "Advanced macromolecule transduction domain (aMTD) peptide, SEQ ID 1.", retrieved from EBI accession no. GSP:BCM49614 Database accession no. BCM49614 *
DATABASE Geneseq [online] 21 April 2016 (2016-04-21), "Advanced macromolecule transduction domain (aMTD) peptide, SEQ ID 121.", retrieved from EBI accession no. GSP:BCM49734 Database accession no. BCM49734 *
DATABASE Geneseq [online] 21 April 2016 (2016-04-21), "Advanced macromolecule transduction domain (aMTD) peptide, SEQ ID 122.", retrieved from EBI accession no. GSP:BCM49735 Database accession no. BCM49735 *
DATABASE Geneseq [online] 21 April 2016 (2016-04-21), "CPP advanced macromolecule transduction domain (aMTD) 1, SEQ ID 1.", retrieved from EBI accession no. GSP:BCM73569 Database accession no. BCM73569 *
DATABASE Geneseq [online] 21 April 2016 (2016-04-21), "CPP advanced macromolecule transduction domain (aMTD) 522, SEQ ID 121.", retrieved from EBI accession no. GSP:BCM73689 Database accession no. BCM73689 *
DATABASE Geneseq [online] 21 April 2016 (2016-04-21), "CPP advanced macromolecule transduction domain (aMTD) 524, SEQ ID 122.", retrieved from EBI accession no. GSP:BCM73690 Database accession no. BCM73690 *
DATABASE Geneseq [online] 27 October 2011 (2011-10-27), "Human SOCS3 protein SEQ:14.", retrieved from EBI accession no. GSP:AZM82651 Database accession no. AZM82651 *
HAWIGER J ED - TAWFIK DAN S ET AL: "NONINVASIVE INTRACELLULAR DELIVERY OF FUNCTIONAL PEPTIDES AND PROTEINS", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 3, no. 1, 1 February 1999 (1999-02-01), pages 89 - 94, XP001009450, ISSN: 1367-5931, DOI: 10.1016/S1367-5931(99)80016-7 *
JO DAEWOONG ET AL: "Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis", NATURE MEDICINE, NATURE PUB. CO, vol. 11, no. 8, 1 August 2005 (2005-08-01), pages 892 - 898, XP002532319, ISSN: 1078-8956, DOI: 10.1038/NM1269 *
See also references of WO2017030323A1 *
TYNETTA C. FLETCHER ET AL: "Extended Anti-inflammatory Action of a Degradation-resistant Mutant of Cell-penetrating Suppressor of Cytokine Signaling 3", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 24, 11 June 2010 (2010-06-11), US, pages 18727 - 18736, XP055467634, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.095216 *

Also Published As

Publication number Publication date
EP3337815A1 (de) 2018-06-27
US20190248849A1 (en) 2019-08-15
US20180291073A1 (en) 2018-10-11
EP3337815B1 (de) 2020-12-16
US10323072B2 (en) 2019-06-18
US10689424B2 (en) 2020-06-23
WO2017030323A1 (en) 2017-02-23

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