EP3334438A1 - Methods of growing acid resistant layers on tooth enamel - Google Patents

Methods of growing acid resistant layers on tooth enamel

Info

Publication number
EP3334438A1
EP3334438A1 EP16835885.1A EP16835885A EP3334438A1 EP 3334438 A1 EP3334438 A1 EP 3334438A1 EP 16835885 A EP16835885 A EP 16835885A EP 3334438 A1 EP3334438 A1 EP 3334438A1
Authority
EP
European Patent Office
Prior art keywords
tooth enamel
acid resistant
delivering
tooth
resistant layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16835885.1A
Other languages
German (de)
French (fr)
Other versions
EP3334438A4 (en
Inventor
Steven D. Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cao Group Inc
Original Assignee
Cao Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cao Group Inc filed Critical Cao Group Inc
Publication of EP3334438A1 publication Critical patent/EP3334438A1/en
Publication of EP3334438A4 publication Critical patent/EP3334438A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention discloses methods of growing acid resistant layers on tooth enamel.
  • Embodiments of the present invention provide methods of growing acid resistant layers on tooth enamel.
  • Figure 1 depicts a layer grown on the enamel surface of a tooth according to an embodiment of the present invention.
  • Tooth caries have plagued centuries since time forgotten. It is known that the acidic by-products of bacterium cause tooth caries as they consume residual food that remain on the teeth after eating. (Bacterium mainly produce lactic acid as a byproduct) Tooth enamel is comprised of calcium hydroxyphosphate, Cas(P0 4 ) 3 0H or hydroxyapatite. Acid ionically dissolves calcium hydroxyphosphate: Ca 5 (P0 4 ) 3 0H (S) + H + ⁇ Ca 5 (P0 4 )3 + + H 2 0 . There have been many means devised to combat caries throughout history, i.e. brushing teeth, fluoridated water, fluoride toothpaste, floss, etc. These methods work by various means; removing the residual food from the teeth after eating, making the enamel more resistant to acid, diluting the acid by stimulating saliva flow, etc.
  • FIG. 1 shows a drawing of a portion of a tooth A; wherein the outermost structure is the enamel surface B. Adhered to the enamel is acid resistant layer C. By creating an acid resistant layer C over tooth structure the incidences of acidic erosion produced by the by-products of bacteria is minimized.
  • the present invention embodies any layer that is grown onto tooth structure that has an acid resistance greater than natural tooth enamel.
  • One embodiment of the present invention is designed to grow an ionically bound crystalline layer over the surface of tooth structure.
  • the embodiment combines a calcium ion source with an acid resistant anion while within the aqueous/saliva environment of the oral cavity.
  • the ionic compounds When combined in solution the ionic compounds begin to precipitate forming a salt; the ions on or at the enamel surface undergo crystalline growth forming a new layer.
  • the process is similar to the re-mineralization processes that occur naturally between saliva and tooth enamel.
  • Saliva contains ionic compounds that grow hydroxyapatite on tooth structure on a constant basis.
  • This embodiment of the present invention is designed to grow a more acid resistant layer over the enamel utilizing the same re-mineralization process as occur naturally within the oral cavity. In this embodiment, we simply incorporate a more acid resistant anion into the newly re-mineralized structure.
  • Another embodiment of the present invention combines calcium ascorbate with sodium monofluorophosphate (MFP) within the oral cavity, upon aqueous dissolution the combined ionic compounds begin to react to form the more stable salt: calcium monofluorophosphate.
  • the calcium and monofluorophosphate ions on or at the enamel surface undergo crystalline growth forming a new layer.
  • the process is similar to the re-mineralization processes that occurs naturally between saliva and tooth enamel.
  • Saliva contains ionic compounds that grow hydroxyapatite on tooth structure on a constant basis.
  • This embodiment of the present invention is designed to grow a more acid resistant layer over the enamel utilizing the same re-mineralization process as occur naturally within the oral cavity. In this embodiment, we merely incorporate the more acid resistant monofluorophosphate anion into the newly re- mineralized tooth layer.
  • ionic compounds of the present invention can be delivered to the oral cavity by various means such as: a 2-part mouthwash, 2-part mixed gel loaded in trays, a 2-part strip that activates when placed into the oral cavity, a 2-part lozenge system that are simultaneously placed into the mouth, and any other useful delivery system that is capable of delivering the components to the oral cavity.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method of reducing tooth decay may include growing one or more acid resistant layers on tooth enamel. The acid resistant layer may include a monofluorophosphate anion. For example the acid resistant layer may include calcium monofluorophosphate. An acid resistant layer may be grown by delivering a two-part compound to the tooth enamel.

Description

METHODS OF GROWING ACID RESISTANT LAYERS
ON TOOTH ENAMEL
TECHNICAL FIELD OF THE INVENTION
[0001] The present invention discloses methods of growing acid resistant layers on tooth enamel.
CROSS-REFERENCES TO RELATED APPLICATIONS
[0002] This application claims the benefit of U.S. Provisional Application No. 62/204,066 filed on August 12, 2015, which is hereby incorporated by reference in its entirety.
SUMMARY
[0003] Embodiments of the present invention provide methods of growing acid resistant layers on tooth enamel.
BRIEF DESCRIPTION OF THE DRAWINGS
[0004] In order to describe the manner in which the above-recited and other advantages and features of the invention can be obtained, a more particular description of the invention briefly described above will be rendered by reference to specific example embodiments thereof which are illustrated in the appended drawings. Understanding that these drawings depict only typical embodiments of the invention and are not therefore to be considered to be limiting of its scope, the invention will be described and explained with additional specificity and detail through the use of the accompanying drawings.
[0005] Figure 1 depicts a layer grown on the enamel surface of a tooth according to an embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION
[0006] Tooth caries have plagued mankind since time forgotten. It is known that the acidic by-products of bacterium cause tooth caries as they consume residual food that remain on the teeth after eating. (Bacterium mainly produce lactic acid as a byproduct) Tooth enamel is comprised of calcium hydroxyphosphate, Cas(P04)30H or hydroxyapatite. Acid ionically dissolves calcium hydroxyphosphate: Ca5(P04)30H(S) + H+→ Ca5(P04)3+ + H20. There have been many means devised to combat caries throughout history, i.e. brushing teeth, fluoridated water, fluoride toothpaste, floss, etc. These methods work by various means; removing the residual food from the teeth after eating, making the enamel more resistant to acid, diluting the acid by stimulating saliva flow, etc.
[0007] The present invention combats caries by growing an acid resistant layer on tooth structure. Figure 1 shows a drawing of a portion of a tooth A; wherein the outermost structure is the enamel surface B. Adhered to the enamel is acid resistant layer C. By creating an acid resistant layer C over tooth structure the incidences of acidic erosion produced by the by-products of bacteria is minimized.
[0008] The present invention embodies any layer that is grown onto tooth structure that has an acid resistance greater than natural tooth enamel.
[0009] One embodiment of the present invention is designed to grow an ionically bound crystalline layer over the surface of tooth structure. The embodiment combines a calcium ion source with an acid resistant anion while within the aqueous/saliva environment of the oral cavity. When combined in solution the ionic compounds begin to precipitate forming a salt; the ions on or at the enamel surface undergo crystalline growth forming a new layer. The process is similar to the re-mineralization processes that occur naturally between saliva and tooth enamel. Saliva contains ionic compounds that grow hydroxyapatite on tooth structure on a constant basis. This embodiment of the present invention is designed to grow a more acid resistant layer over the enamel utilizing the same re-mineralization process as occur naturally within the oral cavity. In this embodiment, we simply incorporate a more acid resistant anion into the newly re-mineralized structure.
[0010] Another embodiment of the present invention combines calcium ascorbate with sodium monofluorophosphate (MFP) within the oral cavity, upon aqueous dissolution the combined ionic compounds begin to react to form the more stable salt: calcium monofluorophosphate. The calcium and monofluorophosphate ions on or at the enamel surface undergo crystalline growth forming a new layer. The process is similar to the re-mineralization processes that occurs naturally between saliva and tooth enamel. Saliva contains ionic compounds that grow hydroxyapatite on tooth structure on a constant basis. This embodiment of the present invention is designed to grow a more acid resistant layer over the enamel utilizing the same re-mineralization process as occur naturally within the oral cavity. In this embodiment, we merely incorporate the more acid resistant monofluorophosphate anion into the newly re- mineralized tooth layer.
[0011] These ionic compounds of the present invention can be delivered to the oral cavity by various means such as: a 2-part mouthwash, 2-part mixed gel loaded in trays, a 2-part strip that activates when placed into the oral cavity, a 2-part lozenge system that are simultaneously placed into the mouth, and any other useful delivery system that is capable of delivering the components to the oral cavity.

Claims

CLAIMS What is claimed is:
1. A method of reducing tooth decay comprising, growing at least one acid resistant layer on tooth enamel.
2. The method of claim 1, wherein the at least one acid resistant layer comprises a monofluorophosphate anion.
3. The method of claim 1, wherein the at least one acid resistant layer comprises calcium monofluorophosphate.
4. The method of claim 1, wherein growing the at least one acid resistant layer on the tooth enamel comprises delivering a two-part compound to the tooth enamel.
5. The method of claim 4, wherein delivering the two-part compound to the tooth enamel comprises delivering a first part comprising calcium ascorbate and a second part comprising sodium monofluorophosphate.
6. The method of claim 4, wherein delivering the two-part compound to the tooth enamel comprises delivering a two-part mouthwash to the tooth enamel.
7. The method of claim 4, wherein delivering the two-part compound to the tooth enamel comprises delivering a two-part gel to the tooth enamel.
8. The method of claim 7, wherein delivering the two-part gel to the tooth enamel loading the two-part gel into a tray.
9. The method of claim 4, wherein delivering the two-part compound to the tooth enamel comprises applying a strip over the tooth enamel.
10. The method of claim 4, wherein delivering the two-part compound to the tooth enamel comprises dissolving a two-part lozenge.
EP16835885.1A 2015-08-12 2016-08-11 Methods of growing acid resistant layers on tooth enamel Withdrawn EP3334438A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562204066P 2015-08-12 2015-08-12
PCT/US2016/046485 WO2017027669A1 (en) 2015-08-12 2016-08-11 Methods of growing acid resistant layers on tooth enamel

Publications (2)

Publication Number Publication Date
EP3334438A1 true EP3334438A1 (en) 2018-06-20
EP3334438A4 EP3334438A4 (en) 2019-02-27

Family

ID=57983758

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16835885.1A Withdrawn EP3334438A4 (en) 2015-08-12 2016-08-11 Methods of growing acid resistant layers on tooth enamel

Country Status (6)

Country Link
US (1) US20180236001A1 (en)
EP (1) EP3334438A4 (en)
JP (1) JP2018522931A (en)
KR (1) KR20180041153A (en)
CN (1) CN107921059A (en)
WO (1) WO2017027669A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379211A (en) * 2018-05-24 2018-08-10 长沙小如信息科技有限公司 A kind of dental care liquid and preparation method thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US16972A (en) * 1857-04-07 Forming spiral springs for chairs
US5460803A (en) * 1989-05-24 1995-10-24 American Dental Association Health Foundation Methods and compositions for mineralizing and fluoridating calcified tissues
FI104044B1 (en) * 1995-07-28 1999-11-15 Tapio Hurme In dental care useful preparation
CN1172647A (en) * 1996-08-06 1998-02-11 吴海元 Dental caries prevention fluoration foam
BR9712036A (en) * 1996-09-12 2000-01-18 Smithkline Beecham Consumer Remineralization composition.
US6685920B2 (en) * 1999-11-12 2004-02-03 The Procter & Gamble Company Method of protecting teeth against erosion
GB0022297D0 (en) * 2000-09-12 2000-10-25 Procter & Gamble Oral compositions
DE602004020583D1 (en) * 2003-02-04 2009-05-28 Gumlink As COMPRESSED RUBBER TABLET
EP1645263B2 (en) * 2003-07-15 2019-04-24 Kao Corporation Oral cavity composition
US20070218018A1 (en) * 2006-03-15 2007-09-20 Discus Dental Impressions, Inc. Sensitivity relief gel
WO2008147997A1 (en) * 2007-05-24 2008-12-04 Ada Foundation Tooth fluoridating and remineralizing compositions and methods, based on nanoaggregate formation
AU2011210805C1 (en) * 2010-01-29 2015-09-17 Colgate-Palmolive Company Oral care product for sensitive enamel care
KR101328162B1 (en) * 2011-06-27 2013-11-13 조선대학교산학협력단 fluorine agent of tape type using biodegradable polymers and manufacturing method thereof
TWI544906B (en) * 2012-07-03 2016-08-11 Xian-Song Zhou Dental care oral care film

Also Published As

Publication number Publication date
CN107921059A (en) 2018-04-17
EP3334438A4 (en) 2019-02-27
JP2018522931A (en) 2018-08-16
US20180236001A1 (en) 2018-08-23
KR20180041153A (en) 2018-04-23
WO2017027669A1 (en) 2017-02-16

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