EP3334330A1 - Procédé de mesure d'un paramètre électrophysiologique au moyen d'un capteur électrode capacitive de capacité controlée - Google Patents

Procédé de mesure d'un paramètre électrophysiologique au moyen d'un capteur électrode capacitive de capacité controlée

Info

Publication number
EP3334330A1
EP3334330A1 EP16750821.7A EP16750821A EP3334330A1 EP 3334330 A1 EP3334330 A1 EP 3334330A1 EP 16750821 A EP16750821 A EP 16750821A EP 3334330 A1 EP3334330 A1 EP 3334330A1
Authority
EP
European Patent Office
Prior art keywords
sensor
subject
capacitive
measuring
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16750821.7A
Other languages
German (de)
English (en)
French (fr)
Inventor
Sylvain ZORMAN
Pierre PROT
Pierre-Yves FROUIN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioserenity SAS
Original Assignee
Bioserenity SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioserenity SAS filed Critical Bioserenity SAS
Publication of EP3334330A1 publication Critical patent/EP3334330A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/251—Means for maintaining electrode contact with the body
    • A61B5/256—Wearable electrodes, e.g. having straps or bands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/277—Capacitive electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/282—Holders for multiple electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/296—Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6804—Garments; Clothes
    • A61B5/6805—Vests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0214—Capacitive electrodes

Definitions

  • the present invention relates to a device for measuring a physiological parameter of a subject, comprising a sensor with capacitive electrodes, and a sensor with capacitive electrodes.
  • GB 2353594A discloses said capacitive electrodes for electrophysiological measurements. But the absence of a suitable geometry does not ensure a repeatable and stable distance with the skin measurement zone, especially in areas with high capillarity such as the scalp. The effective capacitance of the electrode is therefore subject to fluctuations which degrade the recorded signal.
  • An object of the invention is to propose a method for measuring an electrophysiological parameter by means of a capacitive measurement device integrated into a support allowing improved accuracy and ergonomics. This object is achieved by means of a sensor with capacitive electrodes for measuring a physiological parameter of a subject comprising an insulating body, and conductive capacitive elements.
  • the body is made of an electrically insulating material. It comprises a base and a plurality of protuberances projecting from the base. These protuberances make it possible to pass through the capillary elements so that the end of the protuberances is in direct mechanical contact with the measurement zone.
  • Each of the capacitive elements is made of electrically conductive material embedded inside the body.
  • Each capacitive element is disposed inside the body, at one end of the respective protuberances, so that when the ends of the protuberances are in contact with the skin of the subject, the capacitive elements are at a predetermined distance and constant from the skin.
  • the sensor may further have at least one of the following features:
  • the body is formed in one piece of material
  • the body can be formed by molding the electrically insulating material directly on the capacitive elements.
  • the sensor comprises an electronic card extending inside the base of the body, and an electrically conductive wire connecting each capacitive element to the electronic card.
  • the electronic card can be configured to generate a signal for measuring the physiological parameter as a function of the electrical potentials of the capacitive elements.
  • the sensor may also include a shielding layer disposed within the body, and extending over a portion of the base.
  • the shielding layer reduces the sensitivity to electromagnetic disturbances not coming from the measurement zone.
  • the shielding layer can be arranged between the electronic card and the capacitive elements.
  • the invention also relates to a device for measuring a physiological parameter of a subject comprising:
  • a support capable of coating a part of the body of the subject
  • At least one sensor according to the above definition, the sensor being fixed on the support so that when the subject is coated with the support, the support maintains the ends of the protuberances in contact with the skin of the subject.
  • the support allows the sensor to be positioned simply and reproducibly.
  • the support allows the application of a mechanical stress between the sensor and the measurement zone. This mechanical stress makes it possible to minimize the disturbances associated with the movement of the sensor and ensures the mechanical contact of the sensor with the measurement zone.
  • the support is a garment suitable for coating the torso of the subject to allow the recording of an electrocardiogram. In another embodiment of the invention, the support is a garment suitable for coating the head of the subject to enable the recording of an electroencephalogram.
  • the support is a garment adapted to coat the torso of the subject to allow the recording of an electromyogram.
  • the device comprises a reference sensor and one or more measurement sensors. This makes it possible to carry out so-called differential measurements by the use of a so-called reference electrode.
  • the invention further relates to a method of measuring a physiological parameter of a subject, using a measuring device according to the above definition, comprising a step of:
  • the method may also comprise a step consisting in:
  • the correction filter increasing the relative amplitude of certain frequency components of the signal relative to other frequency components.
  • the capacitive elements act as a high-pass filter.
  • This filter modifies the signal which can be considered as an inconvenience.
  • the application of a suitable corrective filter (described below) makes it possible to remedy this defect by correcting the changes in the frequency spectrum a posteriori in order to obtain a signal more representative of the variations of the electrical potential of the measurement zone.
  • FIG. 1 schematically represents an example of a device for measuring an electrophysiological parameter according to a first embodiment of the invention.
  • FIGS. 2A and 2B show, schematically, another example of a device for measuring an electrophysiological parameter according to a second embodiment of the invention.
  • FIG. 3 is a diagrammatic bottom view of a capacitive electrode sensor according to one embodiment of the invention.
  • FIG. 4 is a diagrammatic cross-sectional view of the capacitive electrode sensor of FIG.
  • FIG. 5 schematically represents, in plan view, the capacitive electrode sensor of FIG.
  • FIG. 6A schematically represents an example of an electronic circuit of a capacitive electrode sensor as well as elements external to the capacitive electrode sensor.
  • the device for measuring the electrophysiological signals represented comprises a plurality of capacitive electrode sensors 1 1 fixed on a support 11 1 in order to follow the less an electrophysiological parameter of a subject, for example an electromyogram or an electroencephalogram or an electrocardiogram.
  • the support 11 1 is in the form of a garment, such as a t-shirt or cap, suitable for coating the measuring zone.
  • the support 1 1 1 of the capacitive electrode sensors 1 1 has mechanical properties and a pattern for applying a mechanical stress to the capacitive electrode sensors 1 1 improving the mechanical contact between the tip 33 of the protuberances 34 and the cutaneous measure of the scalp 40.
  • the support of the capacitive electrode sensors is a t-shirt surrounding the bust.
  • the positioning of the capacitive electrode sensors from 13 to 19 allows the recording of cardiac electrical activity and the capacitive electrode sensors 101 to 104 of the electrical activity of muscles at arms and abdomen.
  • the position of the capacitive electrode sensors 1 1 is predefined so that the threading of the measuring device by the user causes the predefined and reproducible positioning of the capacitive electrode sensors 1 1 at locations on the body allowing the measurement of the parameter (s). (s) electrophysiological of interest.
  • the device for measuring a physiological parameter is an electroencephalogram helmet 2.
  • the positions of the capacitive electrode sensors in the cap 1 1 1 follow a well known type 10-20 mounting, as in the embodiment illustrated in Figure 2B.
  • a chin strap 23 may be included in said electroencephalogram helmet 2 so to increase the mechanical stresses on the capacitive electrode sensors at the level of the scalp in order to improve the mechanical contact between the tips 33 of the protuberances 34 and the cutaneous measurement zone 40.
  • Figures 3 and 4 show an embodiment of a capacitive electrode sensor 3.
  • the capacitive electrode sensor 3 comprises a body 32 of electrically insulating material.
  • the body comprises a flat bottom 31 of 0.5 cm to 3 cm and a plurality of protuberances 34 projecting from the base 31.
  • the capacitive electrode sensor 3 further comprises a plurality of capacitive element 301 of electrically conductive material.
  • Each capacitive element 301 is embedded inside the body 32, at the end of a protuberance 34, so that when the ends of the protuberances 34 are disposed in contact with the skin of the subject 40, the capacitive elements 37 extend at a predetermined distance from the skin forming a capacitor with the measuring zone 40.
  • An electronic card 36 extends inside the base 31 of the body 32.
  • Each capacitive element 37 is connected by a wire 38 to the electronic card 36.
  • a connector 35 extends through the body 32 to connect the electronic card 36 to an external physiological recording or signal processing device.
  • the body 32 is preferably formed of a single piece of material, by molding around the capacitive elements 37, the electronic board 36 and the wires 38.
  • the protuberances 34 are distributed so that they are equidistant, according to a periodic or pseudoperiodic arrangement, according to the chosen embodiment.
  • the number, the distance between the protuberances 34, the distribution of the protuberances 34 on the base 31 and the geometry of the protuberances 34 are optimized so that the protuberances 34 can pass through the capillary thickness and in order to establish a direct mechanical contact with the zone cutaneous measurement of the subject.
  • the total absence, or the very small number of capillary elements between the cutaneous measurement zone 40 and the tip 33 of the protuberances 34 resulting from the specificities of the embodiments presented here makes it possible to make it repeatable and stable at During the course of time the distance between the cutaneous measuring zone and the capacitive element 37. This has the effect of making the capacity of the capacitor formed between the cutaneous measuring zone and the capacitive element repeatable and stable over time. 37, to significantly improve the quality of the signals in the context of electro-capacitive sensors.
  • each capacitive element 37 is particularly sensitive to variations in the electric field at the resulting measurement zone 40 (see FIG. 4). Its electrical properties and its physical proximity to the cutaneous measurement zone 40 couple the potential of the capacitive element 37 to the tip of the protuberance 34 to the electrical potential of the nearby cutaneous measurement zone 40.
  • the electrically insulating body 32 surrounds all the elements of the capacitive electrode sensor with the exception of the connector 35.
  • the body 32 also gives the capacitive electrode sensor mechanical resistance properties.
  • the protuberances 34 of 3 to 50 have an elongated shape and a diameter of between 0.5 mm and 3 mm so that they can cross the zones capillaries and be in direct mechanical contact with the skin measurement zone 40.
  • This mechanical contact with the cutaneous measurement zone of the ends 33 of said protuberances is constant during the measurement and ensures a constant and repeatable distance between the capacitive element 37 and the cutaneous measurement zone 40. This characteristic makes it possible to cancel the effects. cutaneous sweating on the measurement of electrophysiological potentials.
  • the thickness of the insulating material of the body 32 separating the capacitive element 37 from the cutaneous measurement zone 40 is between 50 ⁇ and 500 ⁇ depending on the desired characteristics.
  • the value of the effective capacitance constituted by the elements 37 and 40 is a function of the geometry of the protuberances 34 and the number of protuberances 34 per capacitive electrode sensor. More specifically, the capacitance is a function of the diameter of a capacitive element 37, the thickness of insulating material 32 between the elements 37 and the skin measurement zone 40, the electrical permittivity of the insulating material 32 and the number of protuberances 34. This value of the capacitance can be estimated by using the relation c ⁇ € N a / d , with c the effective capacitance of the capacitor formed by the measurement zone 40 and the element
  • the skin measurement zone can be modeled by a plane.
  • the sensor comprises a shielding element 39 disposed inside the body 32 and extending over the width of the base 31.
  • the shielding element 39 associated with the electronic elements 42, 43 and 44 of the capacitive electrode sensor makes it possible to reduce the noise generated by electromagnetic radiation produced by elements outside the measurement zone.
  • the shielding element 39 is held at a particular electrical potential according to a technique of using an operational amplifier 42 whose non-inverting input is electrically connected to the electrically conductive elements 37.
  • the inverting input is connected both to the shielding element 39 and the output of the operational amplifier 42.
  • This electronic assembly called “follower” makes it possible to maintain the electrical potential of the shielding element 39 at the same electrical potential as that of the capacitive elements 301.
  • the shielding element 39 can then act effectively to protect the capacitive elements 301 from electromagnetic disturbances radiated by external devices.
  • the output of the amplifier 42 having the same electrical potential as that present on the capacitive elements 301, it thus conveys a copy of the measured electrophysiological signal.
  • the capacitive electrode sensor comprises an electronic card 36 for amplifying and conditioning the electrophysiological signal copied at the output of the amplifier 42.
  • This amplification and conditioning card comprises an amplifier 43 and resistors 44 and 444 as well as an amplifier.
  • capacitor 45 whose electrical properties make it possible to determine the gain of the amplification. This gain, as well as the values of the resistors 44 and 444 and the capacitor 45, are determined so that the amplified signal level at 43 is sufficient to be correctly digitized by the ADC 47.
  • the resistor 444 and the capacitor 45 just in upstream of the ADC 47 form a low-pass filter whose characteristics can easily be determined.
  • the transfer function of the capacitive electrode sensor is also stable over time and repeatable.
  • the digital filter whose transfer function is predetermined, is always adapted to the transfer function of the electrode 3, which guarantees good signal quality, stable over time, and repeatable.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
EP16750821.7A 2015-08-11 2016-08-10 Procédé de mesure d'un paramètre électrophysiologique au moyen d'un capteur électrode capacitive de capacité controlée Withdrawn EP3334330A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1557676A FR3039979B1 (fr) 2015-08-11 2015-08-11 Procede de mesure d'un parametre electrophysiologique au moyen d'un capteur electrode capacitive de capacite controlee
PCT/EP2016/069019 WO2017025553A1 (fr) 2015-08-11 2016-08-10 Procede de mesure d'un parametre electrophysiologique au moyen d'un capteur electrode capacitive de capacite controlee

Publications (1)

Publication Number Publication Date
EP3334330A1 true EP3334330A1 (fr) 2018-06-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP16750821.7A Withdrawn EP3334330A1 (fr) 2015-08-11 2016-08-10 Procédé de mesure d'un paramètre électrophysiologique au moyen d'un capteur électrode capacitive de capacité controlée

Country Status (10)

Country Link
US (1) US20180235499A1 (ko)
EP (1) EP3334330A1 (ko)
JP (1) JP6858748B2 (ko)
KR (1) KR20180039130A (ko)
CN (1) CN108289609A (ko)
AR (1) AR105682A1 (ko)
FR (1) FR3039979B1 (ko)
IL (1) IL257405A (ko)
TW (1) TW201705904A (ko)
WO (1) WO2017025553A1 (ko)

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FR3039979B1 (fr) 2017-09-01
KR20180039130A (ko) 2018-04-17
JP6858748B2 (ja) 2021-04-14
AR105682A1 (es) 2017-11-01
TW201705904A (zh) 2017-02-16
WO2017025553A1 (fr) 2017-02-16
US20180235499A1 (en) 2018-08-23
CN108289609A (zh) 2018-07-17
JP2018527070A (ja) 2018-09-20
IL257405A (en) 2018-04-30

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