EP3324946A1 - Préparations pharmaceutiques de dabigatran sous forme de base libre - Google Patents

Préparations pharmaceutiques de dabigatran sous forme de base libre

Info

Publication number
EP3324946A1
EP3324946A1 EP16745648.2A EP16745648A EP3324946A1 EP 3324946 A1 EP3324946 A1 EP 3324946A1 EP 16745648 A EP16745648 A EP 16745648A EP 3324946 A1 EP3324946 A1 EP 3324946A1
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical formulation
free base
sodium
mesoporous silica
dabigatran etexilate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16745648.2A
Other languages
German (de)
English (en)
Inventor
Ali TÜRKYILMAZ
Gülay Yelken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanovel Ilac Sanayi ve Ticaret AS
Original Assignee
Sanovel Ilac Sanayi ve Ticaret AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanovel Ilac Sanayi ve Ticaret AS filed Critical Sanovel Ilac Sanayi ve Ticaret AS
Publication of EP3324946A1 publication Critical patent/EP3324946A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds

Abstract

La présente invention concerne une préparation pharmaceutique contenant du dabigatran étexilate sous forme de base libre, de la silice mésoporeuse et au moins un excipient pharmaceutique.
EP16745648.2A 2015-07-20 2016-07-19 Préparations pharmaceutiques de dabigatran sous forme de base libre Withdrawn EP3324946A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR201508948 2015-07-20
PCT/EP2016/067154 WO2017013106A1 (fr) 2015-07-20 2016-07-19 Préparations pharmaceutiques de dabigatran sous forme de base libre

Publications (1)

Publication Number Publication Date
EP3324946A1 true EP3324946A1 (fr) 2018-05-30

Family

ID=56561346

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16745648.2A Withdrawn EP3324946A1 (fr) 2015-07-20 2016-07-19 Préparations pharmaceutiques de dabigatran sous forme de base libre

Country Status (3)

Country Link
EP (1) EP3324946A1 (fr)
MA (1) MA42480A (fr)
WO (1) WO2017013106A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201606697A2 (tr) * 2016-05-20 2017-12-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dabi̇gatranin yeni̇ oral farmasöti̇k formülasyonlari
CN114642646A (zh) * 2020-12-19 2022-06-21 复旦大学 一种甲磺酸达比加群酯胶囊及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
EP1485094B2 (fr) 2002-03-07 2020-03-25 Boehringer Ingelheim International GmbH Forme posologique pour administration par voie orale de l'ethylester d'acide 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino] propionique ou ses sels
DE102005020002A1 (de) 2005-04-27 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
WO2012077136A2 (fr) 2010-12-06 2012-06-14 Msn Laboratories Limited Procédé de préparation de dérivés de benzimidazole et de leurs sels
EP2722034B1 (fr) 2012-10-19 2020-09-16 Sanovel Ilac Sanayi ve Ticaret A.S. Formulations pharmaceutiques orales comprenant du dabigatran
EP2722033A1 (fr) 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Compositions pharmaceutiques de Dabigatran sous forme de base libre
EP2870960A1 (fr) * 2013-11-07 2015-05-13 Siegfried AG Formes galéniques mésoporeuses pour les principes actifs faiblement solubles
CN104706609A (zh) * 2015-04-07 2015-06-17 中国药科大学 一种达比加群酯自乳化分散片及其制备方法

Also Published As

Publication number Publication date
MA42480A (fr) 2018-05-30
WO2017013106A1 (fr) 2017-01-26

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