EP3322355B1 - Ultraschallvorrichtung zur wundbehandlung - Google Patents

Ultraschallvorrichtung zur wundbehandlung Download PDF

Info

Publication number
EP3322355B1
EP3322355B1 EP16824918.3A EP16824918A EP3322355B1 EP 3322355 B1 EP3322355 B1 EP 3322355B1 EP 16824918 A EP16824918 A EP 16824918A EP 3322355 B1 EP3322355 B1 EP 3322355B1
Authority
EP
European Patent Office
Prior art keywords
rim
probe
distal
recess
probe head
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP16824918.3A
Other languages
English (en)
French (fr)
Other versions
EP3322355A4 (de
EP3322355A1 (de
Inventor
Dan Voic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Misonix LLC
Original Assignee
Misonix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Misonix LLC filed Critical Misonix LLC
Publication of EP3322355A1 publication Critical patent/EP3322355A1/de
Publication of EP3322355A4 publication Critical patent/EP3322355A4/de
Application granted granted Critical
Publication of EP3322355B1 publication Critical patent/EP3322355B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
    • A61B2017/320072—Working tips with special features, e.g. extending parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/007—Auxiliary appliance with irrigation system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0017—Wound healing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0034—Skin treatment

Definitions

  • This invention relates to ultrasonic surgical instruments. More particularly, this invention relates to the treatment of wounds with ultrasound energy.
  • the treatment contemplated by this disclosure includes fragmentation and emulsification of hard and soft tissue in a clinical environment while reducing unwanted heat and collateral tissue damage.
  • European Patent No. 2,066,255 discloses a ultrasonic handpiece for making holes in bone tissue comprising a surgical tool provided with a head adapted to make a hole in the bone.
  • the head comprises a plurality of cutting elements defining the profile of the hole to be made in the bone.
  • a main channel which ends in an outlet hole opening into the tool head is provided in the body of the tool for the passage of a cooling fluid, so as to cool the working area affected by the tool head.
  • U.S. Patent No. 8,118,823 discloses a ultrasonic horn comprising: an elongated member having a proximal end, a distal end and a longitudinal axis, the proximal end being adapted to receive ultrasonic waves from a ultrasonic handpiece; a first land member disposed at an annulus at the distal end of the elongated member, the first land member having a first angle with respect to the longitudinal axis; and a second land member disposed at the annulus, the second land member having a second angle, different from the first angle, with respect to said longitudinal axis.
  • Ultrasonic devices which can be used to ablate or cut tissue in surgery are also disclosed by Wuchinich et al. in U.S. Patent No. 4,223,676 and Idemoto et al in U.S. Patent No. 5,188,102 .
  • these surgical devices include a blunt tip hollow probe that vibrates at frequencies between 20 kHz and 100 kHz, with amplitudes up to 300 microns or more.
  • Such devices ablate tissue by either producing cavitation bubbles which implode and disrupt cells, by generating tissue compression and relaxation stresses (sometimes called the jackhammer effect) or by other mechanisms such as micro streaming of bubbles in the tissue matrix.
  • the effect is that the tissue becomes liquefied and separated.
  • the fragmented tissue becomes emulsified with an irrigant solution.
  • the resulting emulsion or slurry of tissue debris is then aspirated from the site.
  • Bulk excision of tissue is possible by applying the energy around and under an unwanted tissue mass to separate it from the surrounding structure. The surgeon can then lift the separated tissue mass out using common tools such as forceps.
  • the tubular probe is excited by a transducer of either the piezoelectric or magnetostrictive type that transforms an alternating electrical signal within the frequencies indicated above into a longitudinal or transverse vibration.
  • a transducer of either the piezoelectric or magnetostrictive type that transforms an alternating electrical signal within the frequencies indicated above into a longitudinal or transverse vibration.
  • the two become a single element with series and parallel resonances.
  • the designer will try to tailor the mechanical and electrical characteristics of these elements to provide the proper frequency of operation.
  • the elements will have a long axis that is straight and has the tip truncated in a plane perpendicular to the long axis. This is done for simplicity and economic considerations. In almost all applications, whether medical or industrial, such an embodiment is practical and useful.
  • the blunt straight probe has been shown to be less effective in removing the hard eschar buildup that occurs when the wound is healing. This eschar buildup must be removed so that the healthy tissue is exposed and allowed to close the wound to provide complete healing with minimal scar tissue formation.
  • the small diameter tip since it is cannulated, has a small annular area with limits energy transmission into the wound. This extends the length of the procedure and causes operator fatigue and patient discomfort.
  • High temperature burns produce a tough, leathery type of eschar. While the eschar can slough off naturally, its removal through surgical debridement is often necessary in order to prevent infection. This is even more important for immuno-compromised patients.
  • a frequently used eschar removal option involves the use of a manual dermatome such as a Week knife. The surgeon cuts thin slices of eschar until the healthy tissue is exposed. Bleeding is the key visual indicator when the Week knife has reached healthy tissue. Ideally, the eschar should be removed without any insult to the healthy tissue below. As this is not possible, the thinner the layer of healthy tissue removed during debridement, the more successful the eschar removal procedure.
  • ultrasonic debridement of wounds has already been proven as an extremely precise, necrotic tissue removal method with the added benefit of minimum impact to the healthy tissue.
  • Ultrasound wound debridement probes are used for debriding complex tissue topographies with minimal loss of healthy tissue. This is not possible to duplicate with sharps, such as scalpels or Week knives .
  • the present invention aims to provide an improved ultrasonic surgical instrument for use in wound treatment. More particularly, the present invention aims to provide such an instrument that will improve wound healing times. Preferably, such an instrument may be easily used in the debridement of wounds that evince a tough, leathery type of eschar.
  • An ultrasonic medical treatment probe in accordance with the present invention comprises a shaft or shank, a connector and a probe head.
  • the connector disposed at one end of the shaft or shank, is configured for coupling to a source of ultrasonic vibratory energy.
  • the probe head is located at an end of the shaft or shank opposite the connector and includes a recess opening onto a distal end plane of the instrument.
  • the probe head has a distal-most rim extending along an endless perimeter around the recess and is formed with a series of serrations or teeth.
  • the distal-most rim is disposed in a plane, exemplarily, but not necessarily, oriented at a 90° angle relative to an axis of the shaft.
  • the rim is circular.
  • the probe head has a cup-shaped configuration, and the rim constitutes an edge of the probe head.
  • the rim is thin in comparison to the width of the recess. While the rim is no thicker than a few millimeters, the recess is typically 5-15 millimeters in diameter. Thus, the diameter of the recess is roughly an order of magnitude larger than the width of the rim.
  • the probe head is provided along the rim with a plurality of notches or openings communicating with the recess.
  • the probe head is provided along the rim with exactly four notches or openings communicating with the recess.
  • the serrations or teeth extend continuously along an entire circumference of the rim, subject to the spaces formed by the notches or openings. The resulting symmetry facilitates use of the device to debride a wound surface.
  • the entire geometry of the probe head is particularly conducive to effective removal of eschar from tissue surfaces having high-temperature burns.
  • An exemplary debridement method utilizes an ultrasonic probe having a shaft or shank, a connector at one end of the shaft or shaft configured for coupling to a source of ultrasonic vibratory energy, and a probe head at an end of the shaft or shank opposite the connector, the probe head including a recess opening onto a distal end plane, the probe head having a distal-most rim extending along an endless uninterrupted perimeter around the recess, the rim being formed with a series of serrations or teeth.
  • the method comprises placing the rim including the serrations or teeth in contact with a target surface of a patient, moving the probe so that the rim moves in a predetermined pattern parallel to and along the target surface while the rim including the serrations or teeth is in contact with the surface, and, during the moving of the probe, generating an ultrasonic standing wave in the probe to vibrate the rim and thereby debride the target surface.
  • liquid is conducted through a channel or bore in the probe shaft to the recess in the probe head during the moving of the probe in contact with the target surface.
  • the predetermined pattern of probe motion may be a series of parallel passes adjacent to and preferably overlapping slightly to ensure removal of a continuous layer of eschar at a burn site.
  • the same result may be achieved by moving the probe in a series of overlapping loops.
  • the loops may be roughly circular and the overlapping circles may be disposed in a linear arrangement to generate a rectangular swath of debrided tissue surface.
  • several passes of looping probe movements may be undertaken to debride a wide area.
  • the moving of the probe is such that the serrated rim is moved laterally within a plane constituting at least a portion of the target surface.
  • the serrated rim of the probe head is vibrated at velocities of 10 to 18 m/s RMS.
  • a combination of frequency-amplitude operational parameters may be selected to ensure such velocities. For example, for 22.5 KHz the output amplitude range that produces the desired speed interval of 10-18m/s RMS is 200-360 um.
  • an ultrasonic medical treatment probe 10 comprises a shaft or shank 12, a connector 14, and a probe head 16.
  • Connector 14, disposed at one end of shaft or shank 12, is configured for coupling to a source of ultrasonic vibratory energy.
  • Probe head 16 is located at an end of shaft or shank 12 opposite the connector 14 and is transversely enlarged so as to define a large recess 18 opening onto a distal end plane 20 of the instrument.
  • Probe head 16 has a distal-most rim 22 extending along an endless or continuous perimeter (a closed loop) around recess 18 and is formed with a series of serrations or teeth 24 pointed or tapering in a distal direction.
  • Distal-most rim 22 is disposed in plane 20 that is, exemplarily, but not necessarily, oriented at a 90° angle relative to an axis of shaft 12, i.e. perpendicular thereto.
  • rim 12 is circular
  • probe head 16 has a cup-shaped configuration
  • rim 22 constitutes an edge of the probe head.
  • the cup shape is typically cylindrical but may be a right rectangular prism that is longer in one transverse dimension than the other.
  • rim 22 is thin in comparison to the width of recess 18. While the rim 22 is no thicker than a few millimeters, the recess is typically at least 5-15 millimeters in diameter. Thus, the diameter of recess 18 is roughly an order of magnitude larger than the width of rim 22.
  • Serrations or teeth 24 extend continuously along an entire circumference of rim 22.
  • the resulting symmetry facilitates use of the device 10 to debride a wound surface.
  • the entire geometry of probe head 16 is particularly conducive to effective removal of eschar from tissue surfaces having high-temperature burns.
  • Probe head 16 is provided along rim 22 with a plurality of mutually spaced notches or openings 26 communicating with recess 18. As illustrated, probe head 16 is provided along rim 22 with exactly four notches or openings 26 communicating with recess 18. Thus, while rim 22 of probe head 16 extends along an endless or continuous perimeter around recess 18, the rim is interrupted along that perimeter by notches or openings 26. Serrations or teeth 24 extend continuously along an entire circumference of rim 22 except for the spaces formed by notches or openings 26.
  • Shaft or shank 12 is formed with a central channel or bore 28 that communicates at a distal end with recess 18 and penetrates at a proximal end through connector 14 for communicating via a handpiece (not shown) with a pressurized source of irrigation liquid.
  • the irrigation liquid is typically a saline solution that may have antibiotic and/or anesthetic constituents.
  • An exemplary wound debridement method which does not belong to the invention, utilizing probe 10 entails manipulating the probe to place rim 22 including serrations or teeth 24 in contact with a target surface of a patient, and moving the probe so that the rim moves in a predetermined pattern parallel to and along the target tissue surface while the rim including the serrations or teeth is in contact with the tissue surface.
  • one generates an ultrasonic standing wave in the probe to vibrate rim 22 and the serrations or teeth 24 thereof, thereby debriding the target surface.
  • Irrigation liquid is conducted through channel or bore 28 in probe shaft 12 to recess 18 in probe head 16 and out through notches 26 (as indicated by arrows 40) during the moving of the probe 10 in contact with the target surface.
  • One pattern of probe motion is a series of parallel passes 30 adjacent to each other and preferably overlapping slightly to thereby ensure removal of a continuous or uninterrupted layer of eschar at a burn site.
  • the parallel passes 30 may be separate, that is, temporally spaced owing to a lifting of the probe 10 away from the target skin surface and a repositioning of the probe prior to motion in the same direction as indicated by arrows 32.
  • alternate passes 30 may be in an opposite direction, with the probe remaining on the target skin surface during the changes in direction of probe motion.
  • FIG. 6 Another pattern of probe motion, shown in FIG. 6 , is a series of overlapping loops 34.
  • the loops 34 are roughly circular and the overlapping circles may be distributed in arrays 36 to generate linear passes each clearing a rectangular swath or path of debrided tissue surface.
  • several debridement passes 36 of looping probe movement may be undertaken to debride a wide area.
  • the parallel passes 36 may be separate, that is, temporally spaced owing to a lifting of the probe 10 away from the target skin surface and a repositioning of the probe prior to motion in the same direction as indicated by arrows 38.
  • alternate looping passes 36 may be in an opposite direction, with the probe remaining on the target skin surface during the changes in direction of probe motion.
  • the moving of probe 10 is such that the serrated rim is moved laterally within a plane constituting at least a portion of the target surface.
  • the serrated rim of the probe head is vibrated at velocities of 10 to 18 m/s RMS.
  • a combination of frequency-amplitude operational parameters may be selected to ensure such velocities. For example, for 22.5 KHz the output amplitude range that produces the desired speed interval of 10-18m/s RMS is 200-360 um.
  • Probe 10 and the use thereof in wound debridement combines the following parameters at the probe-tissue interface: (1) high contact pressure, (2) high velocities of rim 22 and teeth 24, and (3) irrigation via channel 28 and recess 18.
  • Probe 10 has proven highly efficient in the precise and efficient removal of tough, leathery type of eschar produced by high temperature burns.
  • Key elements of probe 10 include an annular contact area fitted with serrated edge 22 to ensure a high contact pressure, needed for tissue penetration and disruption, at the probe-tissue interface.
  • an optimal operation of probe 10 contemplates a combination of frequency-amplitude operational parameters that ensure high velocities exemplarily between 10 and 18m/s RMS.
  • rim 22 has a shape other than circular, for instance, oval or elliptical or oblong with rounded or truncated corners. Accordingly, it is to be understood that the drawings and descriptions herein are proffered by way of example to facilitate comprehension of the invention and should not be construed to limit the scope thereof.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Dentistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgical Instruments (AREA)

Claims (4)

  1. Ultraschallsonde für medizinische Behandlungen, umfassend:
    einen Schaft oder Kolben (12);
    einen Verbinder (14) an einem Ende des Schafts oder Kolbens (12), der für die Kopplung an eine Quelle von Ultraschallschwingungsenergie ausgelegt ist; und
    einen Sondenkopf (16) an einem Ende des Schafts oder Kolbens (12) gegenüber dem Verbinder (14),
    wobei der Sondenkopf (16) eine Ausnehmung (18) beinhaltet, die sich zu einer distalen Endebene hin öffnet, wobei der Sondenkopf (16) einen distalsten Rand (22) aufweist, der sich entlang eines endlosen oder kontinuierlichen Umfangs um die Ausnehmung (18) herum erstreckt, wobei der distalste Rand (22) mit einer Reihe von Zacken oder Zähnen (24) ausgebildet ist,
    wobei der Sondenkopf (16) entlang des distalsten Randes (22) mit einer Vielzahl voneinander beabstandeter Einkerbungen oder Öffnungen (26) versehen ist, die mit der Ausnehmung (18) in Verbindung stehen und den endlosen oder kontinuierlichen Umfang um die Ausnehmung (18) unterbrechen, wobei sich die Zacken oder Zähne (24) durchgehend entlang des gesamten Umfangs des distalsten Randes (22) erstrecken, mit Ausnahme der von den genannten Einkerbungen oder Öffnungen (26) gebildeten Bereiche,
    dadurch gekennzeichnet, dass der distalste Rand (22) eine Kante des Sondenkopfs (16) bildet, der eine becherartige Form aufweist, mit einer konkaven Oberfläche, welche die Ausnehmung (18) definiert, und mit dem distalsten Rand (22), der im Vergleich zu der Breite der Ausnehmung (18) dünn ist, so dass der Durchmesser der Ausnehmung (18) um ungefähr eine Größenordnung größer ist als die Breite des distalsten Randes (22).
  2. Sonde nach Anspruch 1, wobei der distalste Rand (22) in der distalen Endebene orthogonal zu einer Längsachse des Schafts oder Kolbens (12) angeordnet ist.
  3. Sonde nach Anspruch 1 oder 2, wobei der distalste Rand (22) kreisförmig ist.
  4. Sonde nach einem der vorhergehenden Ansprüche, wobei der Sondenkopf (16) entlang des distalsten Randes (22) mit genau vier Einkerbungen oder Öffnungen (26) versehen ist, die mit der Ausnehmung (18) in Verbindung stehen.
EP16824918.3A 2015-07-13 2016-07-07 Ultraschallvorrichtung zur wundbehandlung Active EP3322355B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/797,660 US9872697B2 (en) 2015-07-13 2015-07-13 Ultrasonic wound treatment apparatus and associated method
PCT/US2016/041310 WO2017011263A1 (en) 2015-07-13 2016-07-07 Ultrasonic wound treatment apparatus and associated method

Publications (3)

Publication Number Publication Date
EP3322355A1 EP3322355A1 (de) 2018-05-23
EP3322355A4 EP3322355A4 (de) 2019-02-20
EP3322355B1 true EP3322355B1 (de) 2021-11-03

Family

ID=57757421

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16824918.3A Active EP3322355B1 (de) 2015-07-13 2016-07-07 Ultraschallvorrichtung zur wundbehandlung

Country Status (8)

Country Link
US (2) US9872697B2 (de)
EP (1) EP3322355B1 (de)
JP (1) JP2018520787A (de)
CN (1) CN107847240B (de)
CA (1) CA2992121C (de)
ES (1) ES2905217T3 (de)
HK (1) HK1250000A1 (de)
WO (1) WO2017011263A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD882788S1 (en) * 2018-01-31 2020-04-28 Beijing Smtp Technology Co., Ltd. Ultrasonic cutter head
USD882084S1 (en) * 2018-01-31 2020-04-21 Beijing Smtp Technology Co., Ltd. Ultrasonic cutter head
USD882787S1 (en) * 2018-01-31 2020-04-28 Beijing Smtp Technology Co., Ltd. Ultrasonic cutter head
USD882793S1 (en) * 2018-01-31 2020-04-28 Beijing Smtp Technology Co., Ltd. Ultrasonic cutter head
USD882790S1 (en) * 2018-01-31 2020-04-28 Beijing Smtp Technology Co., Ltd. Ultrasonic cutter head
GB2578089B (en) * 2018-09-25 2022-10-05 Radley Scient Limited Orthopaedic cement removal tools and method
US11980383B2 (en) 2019-12-24 2024-05-14 Farrow Medtech Llc Wound-care apparatus and method for cleansing, desloughing, and debriding wounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223676A (en) 1977-12-19 1980-09-23 Cavitron Corporation Ultrasonic aspirator
JPH0529696Y2 (de) * 1988-11-28 1993-07-29
JP3011730B2 (ja) * 1990-02-13 2000-02-21 住友ベークライト株式会社 超音波手術器用ホーン
AU630294B2 (en) 1990-05-11 1992-10-22 Sumitomo Bakelite Company Limited Surgical ultrasonic horn
US20040181185A1 (en) * 2003-03-14 2004-09-16 Yi-Chang Lee Device for removing diseased surface tissues
WO2006014318A2 (en) * 2004-07-02 2006-02-09 Easley James C Torsional pineapple dissection tip
US7931611B2 (en) 2005-03-23 2011-04-26 Misonix, Incorporated Ultrasonic wound debrider probe and method of use
US20070149881A1 (en) * 2005-12-22 2007-06-28 Rabin Barry H Ultrasonically Powered Medical Devices and Systems, and Methods and Uses Thereof
US7431704B2 (en) * 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
US20080058775A1 (en) 2006-08-29 2008-03-06 Darian Alexander L Ultrasonic debrider probe and method of use
ATE471701T1 (de) * 2006-09-25 2010-07-15 Piezosurgery S R L Handstück mit operationswerkzeug zur anbringung von löchern in knochengeweben
JP2008119250A (ja) * 2006-11-13 2008-05-29 Miwatec:Kk 超音波手術器用ハンドピースおよびホーン
US7682360B2 (en) 2006-12-07 2010-03-23 Tyco Healthcare Group Lp Bipolar tissue debrider and method
US8118823B2 (en) 2008-06-12 2012-02-21 Integra Lifesciences (Ireland) Ltd. Shear stress ultrasonic horn for ultrasonic surgical aspiration
US9259234B2 (en) * 2010-02-11 2016-02-16 Ethicon Endo-Surgery, Llc Ultrasonic surgical instruments with rotatable blade and hollow sheath arrangements
WO2012054882A1 (en) 2010-10-21 2012-04-26 Kci Licensing, Inc. Debridement hand tool
CN104338246A (zh) * 2013-07-25 2015-02-11 厚凯(北京)医疗科技有限公司 一种提高急性伤口清创效率的超声波装置
CN104368246A (zh) 2014-11-10 2015-02-25 苏州蔻美新材料有限公司 一种聚丙烯腈/醋酸纤维复合血液透析膜及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
WO2017011263A1 (en) 2017-01-19
EP3322355A4 (de) 2019-02-20
US9872697B2 (en) 2018-01-23
CA2992121C (en) 2023-11-07
US20180214174A1 (en) 2018-08-02
HK1250000A1 (zh) 2018-11-23
CN107847240A (zh) 2018-03-27
ES2905217T3 (es) 2022-04-07
EP3322355A1 (de) 2018-05-23
CA2992121A1 (en) 2017-01-19
US20170014151A1 (en) 2017-01-19
JP2018520787A (ja) 2018-08-02
US10675052B2 (en) 2020-06-09
CN107847240B (zh) 2021-06-01

Similar Documents

Publication Publication Date Title
EP3322355B1 (de) Ultraschallvorrichtung zur wundbehandlung
US8430897B2 (en) Ultrasonic wound debrider probe and method of use
CA2602485C (en) Ultrasonic wound debrider probe and method of use
WO2008048386A2 (en) Ultrasonic wound debrider probe and method of use
US10980564B2 (en) Ultrasonic debrider probe
JP6567738B2 (ja) 超音波器具アセンブリ及びその製造方法
US20140107412A1 (en) Protective sleeve and associated surgical method
WO2009088390A1 (en) Ultrasonic debrider probe
CA2711770C (en) Ultrasonic wound debrider probe and method of use
WO2008027222A2 (en) Ultrasonic debrider probe

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20180209

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20190123

RIC1 Information provided on ipc code assigned before grant

Ipc: A61B 17/00 20060101ALN20190117BHEP

Ipc: A61B 17/32 20060101AFI20190117BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20191120

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602016065807

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A61B0017220000

Ipc: A61B0017320000

RIC1 Information provided on ipc code assigned before grant

Ipc: A61B 17/00 20060101ALN20210413BHEP

Ipc: A61B 17/32 20060101AFI20210413BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20210527

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1443282

Country of ref document: AT

Kind code of ref document: T

Effective date: 20211115

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602016065807

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20211103

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1443282

Country of ref document: AT

Kind code of ref document: T

Effective date: 20211103

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2905217

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20220407

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220203

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220303

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220303

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220203

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602016065807

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20220804

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20220731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220707

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220731

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220707

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20230726

Year of fee payment: 8

Ref country code: GB

Payment date: 20230718

Year of fee payment: 8

Ref country code: ES

Payment date: 20230804

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20230724

Year of fee payment: 8

Ref country code: DE

Payment date: 20230809

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20160707

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211103