EP3307335A1 - Osteoinductive orthopedic prosthesis - Google Patents

Osteoinductive orthopedic prosthesis

Info

Publication number
EP3307335A1
EP3307335A1 EP16722141.5A EP16722141A EP3307335A1 EP 3307335 A1 EP3307335 A1 EP 3307335A1 EP 16722141 A EP16722141 A EP 16722141A EP 3307335 A1 EP3307335 A1 EP 3307335A1
Authority
EP
European Patent Office
Prior art keywords
osteoinductive
orthopedic prosthesis
metallic body
orthopedic
prosthesis according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP16722141.5A
Other languages
German (de)
French (fr)
Inventor
Patrizio Cremascoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adler Ortho SpA
Original Assignee
Adler Ortho SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adler Ortho SpA filed Critical Adler Ortho SpA
Publication of EP3307335A1 publication Critical patent/EP3307335A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/045—Cobalt or cobalt alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Definitions

  • the present invention relates to an osteoinductive orthopedic prosthesis, particularly but not exclusively useful and practical in the field of orthopedic surgery procedures for arthroplasty, i.e., for complete replacement of the damaged joint of a patient with an orthopedic prosthetic implant of the non-cemented type, constituted by mechanical elements that functionally replace the natural joint.
  • the prosthetic replacement procedure is one of the most frequently performed procedures for the treatment of severe joint pathologies characterized by pain, loss of joint function and deformity, such as for example arthrosis, rheumatoid arthritis, cephalic necrosis, and the outcomes of previous traumas (fracture and/or dislocation).
  • This orthopedic surgical procedure for arthroplasty is an effective biomechanical solution for these joint pathologies and allows patients affected by said pathologies to solve pain or alleviate it significantly, recovering a high quality of life.
  • one of the factors that determine the risk of aseptic mobilization is the degree of osteointegration of the orthopedic prosthesis in the bone.
  • Osteointegration is the process that causes the orthopedic prosthesis to join stably the newly formed trabecular bone; the osteointegrated prosthesis thus becomes firmly incorporated in the bone and cannot be extracted from it or moved.
  • a non-cemented orthopedic prosthesis of the known type is made of biocompatible material, usually titanium alloy, and has a shape and/or a coating of the external surface, constituted by bioactive molecules such as for example collagen, which are adapted to favor and stimulate the growth of bone tissue around it, indeed osteointegration, allowing its final stabilization.
  • osteointegration of the known orthopedic prosthesis in the bone may not reach a degree sufficient to ensure the solidity of the bond between the prosthesis and the bone, leading to situations of aseptic mobilization of the prosthetic implant, the only solution to which is a surgical procedure to revise the arthroplasties.
  • Aseptic mobilization of the orthopedic prosthesis can occur not only due to the insufficient degree of bone integration but also due to the forming of particles of debris, i.e., fragments produced by the wear of the prosthetic implant, in the periarticular space, usually after long periods of repetitive mechanical stress associated with walking.
  • the aim of the present invention is to overcome the limitations of the known art described above, by providing an osteoinductive orthopedic prosthesis that allows to achieve better effects than those obtainable with known orthopedic prostheses, facilitating osteointegration of the orthopedic prosthesis proper in the bone and consequently allowing to have a more stable and durable prosthesis-bone coupling, as well as a reduced risk of revision of the arthroplasty due to aseptic mobilization or prosthetic infection, with an improvement of the quality of life for the prosthetic patient.
  • an object of the present invention is to devise an osteoinductive orthopedic prosthesis that stimulates the process for the forming and taking of trabecular bone around the orthopedic prosthesis proper and within any micro-openings with which it is provided.
  • Another object of the present invention is to devise an osteoinductive orthopedic prosthesis that can be implanted not only a short time after its preparation/manufacture but also after a time period of months or years.
  • a further object of the present invention is to devise an osteoinductive orthopedic prosthesis that allows to minimize bacterial adhesion and, consequently, the risk of infections of the prosthetic implant due to the presence of bacteria.
  • an object of the present invention is to devise an osteoinductive orthopedic prosthesis that allows to reduce the production of particles of debris in the periarticular space.
  • Another object of the present invention is to provide an osteoinductive orthopedic prosthesis that is highly reliable, is relatively simple to provide and at low costs.
  • an osteoinductive orthopedic prosthesis comprising a metallic body, the particularity of which resides in that the external surface of said metallic body comprises a coating of lyophilized collagen.
  • the osteoinductive orthopedic prosthesis according to the invention substantially comprises a body made of metallic material and a coating made of lyophilized collagen arranged on the external surface of the metallic body or on a part of said external surface.
  • the metallic body is preferably made of titanium alloy, even more preferably made of titanium alloy of the Ti6A14V type.
  • the metallic body is preferably made of cobalt alloy, even more preferably of cobalt alloy of the CoCrMo type.
  • the osteoinductive orthopedic prosthesis can also comprise other elements in addition to the above cited metallic body, which usually constitutes its main element, said additional elements depending on the requirements of the case and/or on the uses of the osteoinductive orthopedic prosthesis.
  • the metallic body of the osteoinductive orthopedic prosthesis according to the invention is preferably provided by additive production, i.e., by using additive powder technology, which allows to obtain, at the end of the production cycle, a finished product of high precision without the need to perform additional finishing with traditional machines.
  • calibrated porous lattices having complex structures also made of metallic material, preferably titanium alloy.
  • the external surface of the metallic body has a layer of metal having a three-dimensional porous lattice that comprises undercuts or pores, or more generally empty spaces, formed for example by numerous sharp metallic cusps, which are particularly efficient in providing a seal and accordingly ensure an optimum primary seal with the bone of the prosthetic patient.
  • the metallic cusps of the layer of porous metal of the metallic body have a substantially triangular shape and are inclined at an acute angle, preferably comprised between 3° and 20° and even more preferably equal to 7°.
  • This layer of porous metal of the metallic body of the osteoinductive orthopedic prosthesis according to the invention comprises, as mentioned, undercuts or pores, which are filled with the lyophilized collagen of the coating and allow to accommodate the bone trabeculae of the new bone of the prosthetic patient.
  • Collagen is the most abundant protein in mammals and is the main macromolecular components of the extracellular matrix (ECM) of connective tissue, i.e., of the structure that acts as a support for the cells and connects all tissues of eukaryote organisms, including humans.
  • ECM extracellular matrix
  • This protein due to its very nature and its characteristics, has a great affinity with bone cells, facilitating and stimulating the process for forming and taking of trabecular bone around the metallic body of the osteoinductive orthopedic prosthesis according to the invention, as well as within any undercuts or pores of the layer of porous metal of the metallic body of the osteoinductive orthopedic prosthesis.
  • the lyophilized collagen coating is placed on the external surface of the metallic body of the osteoinductive orthopedic prosthesis according to the invention by means of a dense collagen solution that is subsequently lyophilized.
  • the collagen used for this purpose and more generally the collagen used for medical purposes, is usually extracted from animal tissues.
  • Lyophilization of the collagen coating is performed by means of a corresponding known technological process, which allows to eliminate the water from said organic substance, collagen indeed, with the smallest possible deterioration of the structure and of the components of the substance proper.
  • this process for lyophilization of the collagen coating which as mentioned is arranged on the external surface of the metallic body, allows easy and durable preservation of the osteoinductive orthopedic prosthesis according to the invention, and said preservation can be performed even at ambient temperature and for example for up to five years after the date of preparation/manufacture of the prosthesis proper.
  • the osteoinductive orthopedic prosthesis thus conceived allows to overcome the qualitative limitations of the background art, since it facilitates osteointegration of the orthopedic prosthesis proper in the bone and accordingly allows to have a more stable and durable prosthesis-bone coupling, as well as a reduced risk of revision of the arthroprosthesis due to aseptic mobilization or prosthetic infection, with an improvement of the quality of life for the prosthetic patient.
  • the osteoinductive orthopedic prosthesis according to the invention stimulates the process for the forming and taking of the trabecular bone around the orthopedic prosthesis proper, as well as within any undercuts or pores of the layer of porous metal with which it is provided.
  • osteoinductive orthopedic prosthesis resides in that it can be implanted not only a short time after its preparation/manufacture but also after a period of time of months or years, for example up to a maximum of 5 years.
  • a further advantage of the osteoinductive orthopedic prosthesis according to the invention resides in that it allows to minimize bacterial adhesion and consequently the risk of infections of the prosthetic implant due to the presence of bacteria.
  • osteoinductive orthopedic prosthesis resides in that it allows to reduce the production of debris particles in the periarticular space, in particular by way of the increase in the degree of osteointegration of the orthopedic prosthesis in the bone.
  • osteoinductive orthopedic prosthesis according to the invention has been conceived in particular for orthopedic surgery procedures for arthroplasty, it can in any case be used more generally in the field of any orthopedic surgical procedure, for example as a mechanical elements for the surgical treatment of orthopedic trauma such as fractures and/or dislocations.
  • the invention thus conceived is susceptible of numerous modifications and variations, all of which are within the scope of the appended claims. All the details may further be replaced with other technically equivalent elements.
  • the materials used may be any according to requirements and to the state of the art.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Prostheses (AREA)

Abstract

An osteoinductive orthopedic prosthesis, comprising a metallic body, the external surface of said metallic body comprising a coating of lyophilized collagen.

Description

OSTEOINDUCTIVE ORTHOPEDIC PROSTHESIS
The present invention relates to an osteoinductive orthopedic prosthesis, particularly but not exclusively useful and practical in the field of orthopedic surgery procedures for arthroplasty, i.e., for complete replacement of the damaged joint of a patient with an orthopedic prosthetic implant of the non-cemented type, constituted by mechanical elements that functionally replace the natural joint.
The prosthetic replacement procedure is one of the most frequently performed procedures for the treatment of severe joint pathologies characterized by pain, loss of joint function and deformity, such as for example arthrosis, rheumatoid arthritis, cephalic necrosis, and the outcomes of previous traumas (fracture and/or dislocation).
This orthopedic surgical procedure for arthroplasty is an effective biomechanical solution for these joint pathologies and allows patients affected by said pathologies to solve pain or alleviate it significantly, recovering a high quality of life.
However, these procedures are not always successful; some of these orthopedic surgical procedures are in fact performed to revise arthroplasties as a consequence of implantation failure, mainly due to aseptic mobilization or infections of the prosthetic implant.
In the case of a non-cemented orthopedic prosthesis, one of the factors that determine the risk of aseptic mobilization is the degree of osteointegration of the orthopedic prosthesis in the bone.
Osteointegration is the process that causes the orthopedic prosthesis to join stably the newly formed trabecular bone; the osteointegrated prosthesis thus becomes firmly incorporated in the bone and cannot be extracted from it or moved.
In particular, a non-cemented orthopedic prosthesis of the known type is made of biocompatible material, usually titanium alloy, and has a shape and/or a coating of the external surface, constituted by bioactive molecules such as for example collagen, which are adapted to favor and stimulate the growth of bone tissue around it, indeed osteointegration, allowing its final stabilization.
As already mentioned, however, osteointegration of the known orthopedic prosthesis in the bone may not reach a degree sufficient to ensure the solidity of the bond between the prosthesis and the bone, leading to situations of aseptic mobilization of the prosthetic implant, the only solution to which is a surgical procedure to revise the arthroplasties.
Aseptic mobilization of the orthopedic prosthesis can occur not only due to the insufficient degree of bone integration but also due to the forming of particles of debris, i.e., fragments produced by the wear of the prosthetic implant, in the periarticular space, usually after long periods of repetitive mechanical stress associated with walking.
These debris particles lead, in the prosthetic patient, to a biological response that is characterized by inflammation in the directly adjacent bone, culminating with bone loss and mobilization of the prosthetic implant.
The aim of the present invention is to overcome the limitations of the known art described above, by providing an osteoinductive orthopedic prosthesis that allows to achieve better effects than those obtainable with known orthopedic prostheses, facilitating osteointegration of the orthopedic prosthesis proper in the bone and consequently allowing to have a more stable and durable prosthesis-bone coupling, as well as a reduced risk of revision of the arthroplasty due to aseptic mobilization or prosthetic infection, with an improvement of the quality of life for the prosthetic patient.
Within this aim, an object of the present invention is to devise an osteoinductive orthopedic prosthesis that stimulates the process for the forming and taking of trabecular bone around the orthopedic prosthesis proper and within any micro-openings with which it is provided.
Another object of the present invention is to devise an osteoinductive orthopedic prosthesis that can be implanted not only a short time after its preparation/manufacture but also after a time period of months or years.
A further object of the present invention is to devise an osteoinductive orthopedic prosthesis that allows to minimize bacterial adhesion and, consequently, the risk of infections of the prosthetic implant due to the presence of bacteria.
Moreover, an object of the present invention is to devise an osteoinductive orthopedic prosthesis that allows to reduce the production of particles of debris in the periarticular space.
Another object of the present invention is to provide an osteoinductive orthopedic prosthesis that is highly reliable, is relatively simple to provide and at low costs.
This aim, as well as these and other objects that will become better apparent hereinafter, are achieved by an osteoinductive orthopedic prosthesis, comprising a metallic body, the particularity of which resides in that the external surface of said metallic body comprises a coating of lyophilized collagen.
Further characteristics and advantages of the invention will become better apparent from the description of a preferred but not exclusive embodiment of the osteoinductive orthopedic prosthesis according to the present invention.
The osteoinductive orthopedic prosthesis according to the invention substantially comprises a body made of metallic material and a coating made of lyophilized collagen arranged on the external surface of the metallic body or on a part of said external surface.
In one embodiment of the osteoinductive orthopedic prosthesis according to the invention, the metallic body is preferably made of titanium alloy, even more preferably made of titanium alloy of the Ti6A14V type.
In another embodiment of the osteoinductive orthopedic prosthesis according to the invention, the metallic body is preferably made of cobalt alloy, even more preferably of cobalt alloy of the CoCrMo type.
In a possible embodiment of the invention, the osteoinductive orthopedic prosthesis can also comprise other elements in addition to the above cited metallic body, which usually constitutes its main element, said additional elements depending on the requirements of the case and/or on the uses of the osteoinductive orthopedic prosthesis.
The metallic body of the osteoinductive orthopedic prosthesis according to the invention is preferably provided by additive production, i.e., by using additive powder technology, which allows to obtain, at the end of the production cycle, a finished product of high precision without the need to perform additional finishing with traditional machines.
Furthermore, by means of additive powder technology it is possible to obtain calibrated porous lattices having complex structures, also made of metallic material, preferably titanium alloy.
In a preferred embodiment of the osteoinductive orthopedic prosthesis according to the invention, the external surface of the metallic body has a layer of metal having a three-dimensional porous lattice that comprises undercuts or pores, or more generally empty spaces, formed for example by numerous sharp metallic cusps, which are particularly efficient in providing a seal and accordingly ensure an optimum primary seal with the bone of the prosthetic patient.
In an even more preferred embodiment of the osteoinductive orthopedic prosthesis according to the invention, the metallic cusps of the layer of porous metal of the metallic body have a substantially triangular shape and are inclined at an acute angle, preferably comprised between 3° and 20° and even more preferably equal to 7°.
This layer of porous metal of the metallic body of the osteoinductive orthopedic prosthesis according to the invention comprises, as mentioned, undercuts or pores, which are filled with the lyophilized collagen of the coating and allow to accommodate the bone trabeculae of the new bone of the prosthetic patient.
Collagen is the most abundant protein in mammals and is the main macromolecular components of the extracellular matrix (ECM) of connective tissue, i.e., of the structure that acts as a support for the cells and connects all tissues of eukaryote organisms, including humans.
This protein, due to its very nature and its characteristics, has a great affinity with bone cells, facilitating and stimulating the process for forming and taking of trabecular bone around the metallic body of the osteoinductive orthopedic prosthesis according to the invention, as well as within any undercuts or pores of the layer of porous metal of the metallic body of the osteoinductive orthopedic prosthesis.
The lyophilized collagen coating is placed on the external surface of the metallic body of the osteoinductive orthopedic prosthesis according to the invention by means of a dense collagen solution that is subsequently lyophilized. The collagen used for this purpose, and more generally the collagen used for medical purposes, is usually extracted from animal tissues.
Lyophilization of the collagen coating is performed by means of a corresponding known technological process, which allows to eliminate the water from said organic substance, collagen indeed, with the smallest possible deterioration of the structure and of the components of the substance proper.
In particular, this process for lyophilization of the collagen coating, which as mentioned is arranged on the external surface of the metallic body, allows easy and durable preservation of the osteoinductive orthopedic prosthesis according to the invention, and said preservation can be performed even at ambient temperature and for example for up to five years after the date of preparation/manufacture of the prosthesis proper.
In practice it has been found that the invention achieves fully the intended aim and objects. In particular it has been shown that the osteoinductive orthopedic prosthesis thus conceived allows to overcome the qualitative limitations of the background art, since it facilitates osteointegration of the orthopedic prosthesis proper in the bone and accordingly allows to have a more stable and durable prosthesis-bone coupling, as well as a reduced risk of revision of the arthroprosthesis due to aseptic mobilization or prosthetic infection, with an improvement of the quality of life for the prosthetic patient.
In particular, the osteoinductive orthopedic prosthesis according to the invention stimulates the process for the forming and taking of the trabecular bone around the orthopedic prosthesis proper, as well as within any undercuts or pores of the layer of porous metal with which it is provided.
Another advantage of the osteoinductive orthopedic prosthesis according to the invention resides in that it can be implanted not only a short time after its preparation/manufacture but also after a period of time of months or years, for example up to a maximum of 5 years.
A further advantage of the osteoinductive orthopedic prosthesis according to the invention resides in that it allows to minimize bacterial adhesion and consequently the risk of infections of the prosthetic implant due to the presence of bacteria.
Another advantage of the osteoinductive orthopedic prosthesis according to the invention resides in that it allows to reduce the production of debris particles in the periarticular space, in particular by way of the increase in the degree of osteointegration of the orthopedic prosthesis in the bone.
Although the osteoinductive orthopedic prosthesis according to the invention has been conceived in particular for orthopedic surgery procedures for arthroplasty, it can in any case be used more generally in the field of any orthopedic surgical procedure, for example as a mechanical elements for the surgical treatment of orthopedic trauma such as fractures and/or dislocations. The invention thus conceived is susceptible of numerous modifications and variations, all of which are within the scope of the appended claims. All the details may further be replaced with other technically equivalent elements.
In practice, the materials used, as well as the contingent shapes and dimensions, may be any according to requirements and to the state of the art.
To conclude, the scope of the protection of the claims must not be limited by the illustrations or preferred embodiments shown in the description by way of example, but rather the claims must comprise all the characteristics of patentable novelty that reside in the present invention, including all the characteristics that would be treated as equivalents by the person skilled in the art.
The disclosures in Italian Patent Application No. 102015000022618 (UB2015A001337) from which this application claims priority are incorporated herein by reference.
Where technical features mentioned in any claim are followed by reference signs, those reference signs have been included for the sole purpose of increasing the intelligibility of the claims and accordingly such reference signs do not have any limiting effect on the interpretation of each element identified by way of example by such reference signs.

Claims

1. An osteoinductive orthopedic prosthesis, comprising a metallic body, characterized in that the external surface of said metallic body comprises a coating of lyophilized collagen.
2. The osteoinductive orthopedic prosthesis according to claim 1, characterized in that said metallic body is provided by using additive powder technology.
3. The osteoinductive orthopedic prosthesis according to claim 1 or 2, characterized in that said external surface of said metallic body comprises a layer of porous metal, said lyophilized collagen coating filling the spaces within said porous layer.
4. The osteoinductive orthopedic prosthesis according to claim 3, characterized in that said porous layer is constituted by sharp metallic cusps.
5. The osteoinductive orthopedic prosthesis according to claim 4, characterized in that said cusps have a substantially triangular shape and an inclination comprised between 3° and 20°.
6. The osteoinductive orthopedic prosthesis according to one or more of the preceding claims, characterized in that said metallic body is made of titanium alloy of the Ti6A14V type.
7. The osteoinductive orthopedic prosthesis according to one or more of the preceding claims, characterized in that said metallic body is made of cobalt alloy of the CoCrMo type.
EP16722141.5A 2015-06-11 2016-05-06 Osteoinductive orthopedic prosthesis Ceased EP3307335A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUB20151337 2015-06-11
PCT/EP2016/060172 WO2016198215A1 (en) 2015-06-11 2016-05-06 Osteoinductive orthopedic prosthesis

Publications (1)

Publication Number Publication Date
EP3307335A1 true EP3307335A1 (en) 2018-04-18

Family

ID=54199941

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16722141.5A Ceased EP3307335A1 (en) 2015-06-11 2016-05-06 Osteoinductive orthopedic prosthesis

Country Status (2)

Country Link
EP (1) EP3307335A1 (en)
WO (1) WO2016198215A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107998446B (en) * 2017-12-27 2021-10-15 北京银河巴马生物技术股份有限公司 Medical titanium mesh with tissue engineering stent covering film and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664501B1 (en) * 1990-07-16 1995-05-12 Osteal Medical Laboratoires COMPOSITE MATERIAL FOR BONE IMPLANT AND METHOD FOR IMPLEMENTING SAME.
CN101229394B (en) * 2007-01-24 2013-05-22 张立海 Titanium alloy-collagen-hydroxyl apatite bone repairing material and preparing method thereof
US8790402B2 (en) * 2012-01-09 2014-07-29 Zimmer, Inc. Composite device that combines porous metal and bone stimuli
WO2015116646A1 (en) * 2014-01-28 2015-08-06 Mccoy Enterprises, Llc Collagen permeated medical implants

Also Published As

Publication number Publication date
WO2016198215A1 (en) 2016-12-15

Similar Documents

Publication Publication Date Title
CN105105875B (en) A kind of biomimetic prosthetic hip joint with interior growth function
US20190038421A1 (en) Artificial alpha femoral stem prosthesis
CN109453425B (en) Anti-infection osteogenesis-promoting titanium alloy implant and preparation method thereof
US20110202140A1 (en) Load bearing implants with engineered gradient stiffness and associated systems and methods
JP2008531146A (en) Set that constitutes a surface reconstruction hip implant
Krishnamurithy A review on hydroxyapatite-based scaffolds as a potential bone graft substitute for bone tissue engineering applications
JP7142000B2 (en) Implants and joint implants
CN110368140B (en) Femoral implant
CN107224616B (en) Artificial joint preparation method
EP3307335A1 (en) Osteoinductive orthopedic prosthesis
CN107753155A (en) Bone grafting merges steady type artificial hip joint femoral shaft
JP6718908B2 (en) α type artificial femoral stem prosthesis
Fouda Horizontal functionally graded material coating of cementless hip prosthesis
CN105816917A (en) High-toughness super-wear-resistance artificial bone for repairing bone defects and preparation method thereof
Markov et al. Scientific approaches to the creation of biocompatible implant materials
CN210019806U (en) Artificial joint casting
CN211131550U (en) Femoral implant
CN203354696U (en) Cross-shaped hollow biological-type femoral stem
CN110215319A (en) Artificial joint prosthesis with bionic function is preparing the application in large segmental bone defect reconstruction biomaterials
CN204049936U (en) For the femur side prosthesis of hip replacement
Czub et al. Usefulness of CorMatrix-based tricuspid valve repair in the treatment of infective endocarditis
US10765523B2 (en) Prosthesis component and method for the production thereof
Mohamed An Overview of Orthopedic Implants
WO2019166021A1 (en) Artificial joint prosthesis having biomimetic function
RU2810013C2 (en) Method of replacing bone defects and electret implant for its implementation

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20180104

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20181030

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20200513