EP3288545A1 - Thérapie à combinaison d'agent anti-fugetaxis et d'agent d'immunothérapie et compositions pour le traitement du cancer - Google Patents

Thérapie à combinaison d'agent anti-fugetaxis et d'agent d'immunothérapie et compositions pour le traitement du cancer

Info

Publication number
EP3288545A1
EP3288545A1 EP16722468.2A EP16722468A EP3288545A1 EP 3288545 A1 EP3288545 A1 EP 3288545A1 EP 16722468 A EP16722468 A EP 16722468A EP 3288545 A1 EP3288545 A1 EP 3288545A1
Authority
EP
European Patent Office
Prior art keywords
agent
cell
fugetactic
cancer
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16722468.2A
Other languages
German (de)
English (en)
Inventor
Mark C. Poznansky
Patrick Reeves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of EP3288545A1 publication Critical patent/EP3288545A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/195Chemokines, e.g. RANTES
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2053IL-8
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4613Natural-killer cells [NK or NK-T]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La présente invention concerne des méthodes et des compositions pour traiter le cancer chez un patient, ou une cellule tumorale, par l'administration d'une quantité efficace d'un agent "anti-fugetaxis" (ou chimiorépulsif) et d'un agent d'immunothérapie.
EP16722468.2A 2015-04-25 2016-04-25 Thérapie à combinaison d'agent anti-fugetaxis et d'agent d'immunothérapie et compositions pour le traitement du cancer Withdrawn EP3288545A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562152833P 2015-04-25 2015-04-25
PCT/US2016/029254 WO2016176154A1 (fr) 2015-04-25 2016-04-25 Thérapie à combinaison d'agent anti-fugetaxis et d'agent d'immunothérapie et compositions pour le traitement du cancer

Publications (1)

Publication Number Publication Date
EP3288545A1 true EP3288545A1 (fr) 2018-03-07

Family

ID=55967434

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16722468.2A Withdrawn EP3288545A1 (fr) 2015-04-25 2016-04-25 Thérapie à combinaison d'agent anti-fugetaxis et d'agent d'immunothérapie et compositions pour le traitement du cancer

Country Status (11)

Country Link
US (1) US20180117006A1 (fr)
EP (1) EP3288545A1 (fr)
JP (1) JP2018513202A (fr)
KR (1) KR20180021684A (fr)
CN (1) CN108135939A (fr)
AU (1) AU2016256366A1 (fr)
CA (1) CA2983755A1 (fr)
IL (1) IL255169A0 (fr)
MX (1) MX2017013666A (fr)
RU (1) RU2017140777A (fr)
WO (1) WO2016176154A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2999094A1 (fr) * 2015-09-18 2017-03-23 The General Hospital Corporation Dba Massachusetts General Hospital Compositions possedant des proprietes antichimiorepulsion pour le traitement du cancer
CA2999083A1 (fr) * 2015-09-18 2017-03-23 The General Hospital Corporation Dba Massachusetts General Hospital Apport localise d'un agent antichimiorepulsion pour le traitement du cancer
EP3505183B1 (fr) * 2016-08-26 2022-03-30 Tetsuji Okuno Agent diminuant le débit sanguin microvasculaire et son utilisation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034332B2 (en) * 1997-04-30 2011-10-11 Conkwest, Inc. Interleukin-secreting natural killer cell lines and methods of use
WO2006137934A2 (fr) * 2004-11-05 2006-12-28 The General Hospital Corporation Eloignement volontaire de cellules migratoires humaines d'une source d'agents
EP2679238A1 (fr) * 2008-10-02 2014-01-01 Celtaxsys, INC. Méthodes de modulation de la chimotaxie négative de cellules immunitaires
KR101609641B1 (ko) * 2009-07-28 2016-04-07 삼성전자주식회사 무선통신 시스템에서 자동 이웃 관계 구성 및 최적화를 위한 장치 및 방법
WO2012047339A2 (fr) * 2010-06-28 2012-04-12 The General Hospital Corporation Anti-cxcr4 en tant que sensibilisant à des agents de traitement d'un cancer
AU2011329638C1 (en) * 2010-11-18 2017-04-27 The General Hospital Corporation Novel compositions and uses of anti-hypertension agents for cancer therapy
CN103736092A (zh) * 2012-08-09 2014-04-23 清华大学 抑制新生淋巴管生成的方法和药物
EP3030322A2 (fr) * 2013-08-05 2016-06-15 Cambridge Enterprise Limited Inhibition de la signalisation cxr4 en immunothérapie anticancéreuse
EP3049065A1 (fr) * 2013-09-26 2016-08-03 BioNTech AG Particules comprenant une coque contenant de l'arn

Also Published As

Publication number Publication date
US20180117006A1 (en) 2018-05-03
JP2018513202A (ja) 2018-05-24
IL255169A0 (en) 2017-12-31
RU2017140777A3 (fr) 2019-11-05
AU2016256366A1 (en) 2017-12-07
KR20180021684A (ko) 2018-03-05
MX2017013666A (es) 2018-07-06
CN108135939A (zh) 2018-06-08
RU2017140777A (ru) 2019-05-28
CA2983755A1 (fr) 2016-11-03
WO2016176154A1 (fr) 2016-11-03

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