EP3243064A1 - Dispositif d'analyse de traces en ligne d'un liquide - Google Patents

Dispositif d'analyse de traces en ligne d'un liquide

Info

Publication number
EP3243064A1
EP3243064A1 EP16706123.3A EP16706123A EP3243064A1 EP 3243064 A1 EP3243064 A1 EP 3243064A1 EP 16706123 A EP16706123 A EP 16706123A EP 3243064 A1 EP3243064 A1 EP 3243064A1
Authority
EP
European Patent Office
Prior art keywords
microchannel
liquid
housing
light
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16706123.3A
Other languages
German (de)
English (en)
Inventor
Gerhard Kirschner
Thomas Wisspeintner
Martin SCZEPAN
Helmut Hummel
Alfred Lechner
Michael BAUHUBER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro Epsilon Messtechnik GmbH and Co KG
Original Assignee
Micro Epsilon Messtechnik GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Epsilon Messtechnik GmbH and Co KG filed Critical Micro Epsilon Messtechnik GmbH and Co KG
Publication of EP3243064A1 publication Critical patent/EP3243064A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
    • G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
    • G01N1/2042—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping using a piston actuated by the pressure of the liquid to be sampled
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids

Definitions

  • the invention relates to a device for inline trace analysis of a liquid, preferably an aqueous process solution.
  • Devices for trace analysis of a liquid and in particular an aqueous process solution are of great importance, for example, in the semiconductor industry, since even the slightest contamination of process solutions can render complete batches unusable in production. To increase productivity and reduce production downtime, continuous monitoring of the purity of process media is essential. Furthermore, the drinking and wastewater analysis represents a future broad market for the device according to the invention. Due to the ever-decreasing permissible pollutant levels in wastewater, described in the EU water protection guidelines, it is necessary in many areas to detect minimal contamination.
  • a device for trace analysis of a liquid is already known from EP 2 486 388 B1.
  • the known device has a microchannel designed as a liquid optical waveguide on a substrate in the form of a silicon wafer. Through this microchannel a liquid to be examined is flowed through. Furthermore, light from a light source is coupled into the microchannel and light emerging from the microchannel is analyzed by a detector. Different methods of analysis are used, for example spectroscopic methods based on absorption, transmission, fluorescence and Raman scattering. Detection of substances in liquids in the sub-ppb range is possible with the known device.
  • the embodiment of the known device described in EP 2 486 388 B1 makes it possible to realize a miniaturized device which nevertheless creates a long light path within the liquid to be examined in the microchannel.
  • the present invention is based on the object, such a device of the aforementioned type and further develop that a safe and easy handling of the device is made possible as an inline measuring device with structurally simple means. According to the invention the above object is achieved by a device having the features of claim 1.
  • the apparatus comprises a housing, a microchannel through which the liquid to be examined is flowed and coupled into the light of a light source, a detector for light emerging from the microchannel, and a user interface for monitoring and / or operating the device, wherein the Microchannel, the detector and / or the user interface are arranged in the housing and / or integrated into the housing and wherein the housing has a connection for supplying the liquid into the micro-channel and a connection for the power supply of the device.
  • housing is a housing in the broadest sense.
  • the housing can be formed only by a support plate or a frame.
  • a closed embodiment of the housing is also encompassed by the general term "housing".
  • both the microchannel and the detector are arranged in a housing or integrated in the housing.
  • the housing has in a further inventive manner a connection for supplying the liquid to be examined in the micro-channel.
  • the housing has a secure power supply to the device Connection to the power supply of the device.
  • a user interface is realized, which is arranged in the housing or integrated in the housing. This user interface serves to monitor and / or operate the device.
  • the light source can be arranged in the housing. Separate feeding of light from outside the housing into the microchannel is not required here.
  • the housing may have a terminal for feeding the light of the light source into the microchannel.
  • Such a connection allows the flexible use of different light sources, wherein the selected light source only has to be coupled to the connection from outside the housing.
  • an LED light source can be used, which brings a long life and low heat development.
  • an LED light source is also very well suited for installation in the housing, without any fear that a high heat development affects the function of the device.
  • Another advantage of an LED light source is that the spectral distribution of the light is controllable to some extent. Thus, the spectrum of the substance to be examined can be adapted. However, depending on the application, it is also possible to use halogen light sources, tunable laser light sources or other light sources.
  • the housing may have a connection for discharging the liquid from the microchannel.
  • the liquid to be examined can be supplied from the outside both into the housing and thus into the microchannel and removed from the housing after an analysis.
  • a collecting container for exiting the microchannel liquid may be arranged in the housing. In this case, the liquid to be examined is passed after the analysis in the collection container, which can be emptied when it reaches a predetermined level in a suitable manner.
  • the collecting container can be removably disposed in the housing, so that it can be taken to the emptying of the housing.
  • a reference channel can be realized, which can be provided, for example, in the form of an optical waveguide, which can run virtually parallel to the microchannel.
  • a reference spectrum and, on the other hand, a measurement spectrum can be compared with one another in order to realize a reliable measurement result.
  • an attenuator can be assigned to the reference channel.
  • a switching device for the light can furthermore be assigned to the reference channel, so that either the light guided through the microchannel or through the reference channel can be measured in the detector.
  • the switching device could be realized as a shutter or shutter.
  • the switching device can be arranged, for example, directly in front of a spectrometer or detector.
  • the switching device allows a simple embodiment of the detector in the form of, for example, a line detector, since only light from a channel is to be detected.
  • the switching device can turn off both the measuring and the reference channel, so that no light falls on the detector.
  • the dark current of the detector can be determined and the dark balance can be performed.
  • both the light conducted through the microchannel and through the reference channel can be blocked from or in front of the detector.
  • the device according to the invention serves to detect the slightest traces of substances in a liquid.
  • the substance to be detected can often not be detected directly, but only after a successful detection reaction.
  • the analyte - the analyte - a complexing agent is fed, which triggers the detection reaction.
  • Analyte and complexing agent can be combined in a mixer.
  • the mixer can be a structured component, where an efficient mixing takes place. In a particularly simple manner, the mixer simply consists of a coupling point, where the two liquids flow together.
  • the product of the detection reaction can be detected, for example, by means of an absorption measurement.
  • safety valves can be used which ensure the required safety in operation and in the handling of the device when supplying the liquid, the analyte or a complexing agent.
  • the safety valves can serve in case of impermissible or undesired operating states of the device to prevent the supply and / or the discharge of the liquid and / or an analyte and / or a complexing agent.
  • Impermissible or undesired operating states can be, for example, the exceeding of a predefinable pressure, the failure of system-relevant components or the escape of liquids-leakage.
  • the safety valves can prevent the return of liquids in the parent system.
  • a supply line for supplying and / or a discharge for discharging the liquid and / or an analyte and / or a complexing agent and / or the microchannel can be activated - if a predeterminable pressure in the supply line is exceeded; be associated in the derivative or in the micro-channel responsive - safety valve.
  • a safety valve can be used wherever liquid, analyte or complexing agents are added or removed.
  • a moisture sensor or leakage sensor can be arranged in the housing.
  • a moisture sensor or leakage sensor can respond to an undesired leakage of a liquid and provide a suitable signal and possibly to transmit an alarm device.
  • a moisture sensor or leakage sensor may be disposed in a liquid sump which may be located at a suitable location in the housing, preferably below or below the microchannel.
  • the signal of the moisture or leakage sensor can be used to control the safety valves and to prevent the supply and / or the removal of the liquid and / or the analyte and / or the complexing agent.
  • a shut-off device for the device and / or a pump or piezomembrane pump can be assigned to the moisture sensor or leakage sensor.
  • Such pumps or piezomembrane pumps can be used to conveniently transport the liquid, the analyte or a complexing agent. For a safe operation of the device and a safe measurement must be taken to ensure that there are no air bubbles or arise in the supply lines or in the micro-channel.
  • a feed line for supplying the liquid and / or an analyte and / or a complexing agent and / or the microchannel can be assigned a degassing device.
  • a degassing device can have, for example, a semipermeable membrane and a vacuum pump. Not only air bubbles but also, for example, gases dissolved in the liquid, such as oxygen, should be removed as much as possible in order to ensure reliable measurement.
  • an analyte or a complexing agent a supply line for supplying and / or a discharge for discharging the liquid and / or an analyte and / or a complexing agent and / or the Micro channel to be associated with a flow meter.
  • a flow measuring device can preferably be used for controlling or controlling a flow rate.
  • the flow measuring device may in this connection be coupled with suitable pumps for influencing the flow rate.
  • the flow rate of an analyte and / or a As a result, complexing agent can be specified precisely and suitable mixing ratios can be exactly realized.
  • a feed line and / or a discharge line for discharging the liquid and / or an analyte and / or a complexing agent and / or the microchannel may be assigned a suitable pump, in particular a piezomembrane pump.
  • the device may comprise a rinsing device for a supply line for supply and / or a discharge for discharging the liquid and / or an analyte and / or a complexing agent and / or for the microchannel.
  • a flushing of the liquid lines of the device may be required. This can be realized in a simple manner by such a flushing device.
  • the liquid-carrying components - feeders, outlets, pumps, safety valves, degassing devices, microchannel, etc. - can be mounted on a collecting trough.
  • the drip pan serves to catch the liquids during leaks and to supply them to a moisture or leakage sensor.
  • this unit - also known as fluidic module - can be easily replaced.
  • a particular advantage of this modular design is that multiple units can be installed in one housing, creating a multi-channel system in which several different fluids can be tested.
  • the optical components have multiple inputs and outputs, so that they can be used for several measurement channels.
  • only the switching device is equipped with more than two channels, for example with four channels. It will be one for the reference channel, while the remaining three are available for measurement channels.
  • only the fluidic module needs to be double, triple or multiple, while the spectrometer and light source are simply present.
  • the microchannel usually has a coating of a suitable plastic, for example Teflon® .
  • Teflon® a suitable plastic
  • this plastic coating favors the formation of harmful bacteria and germs in the microchannel, which significantly affects the quality of the measurement.
  • nucleation In addition to nucleation also leads to an accumulation of gas bubbles, in particular of oxygen bubbles, in the micro channel to a deterioration of the measurement.
  • the microchannel can be assigned a UV irradiation device for irradiating UV light into the microchannel.
  • the UV light can be radiated away from the detector counter to the measuring direction through the microchannel.
  • the UV irradiation device can be designed such that an irradiation of the UV light is made possible in both ends of the microchannel. This allows the UV light to safely enter the microchannel from two sides.
  • a particularly effective light source for the UV light at this point is a xenon flash lamp. Since the flash lamp is operated pulsed, the total radiant power can be adjusted specifically for the killing of bacteria and germs and / or the prevention of gas bubbles. The pulsed operation also reduces the power loss - waste heat - in the housing. Another advantage of the pulsed operation is the possible synchronization with the detector, whereby the possible influence of the measurement is further reduced eg by stray light.
  • UV light source to kill bacteria and germs can be placed in front of the microchannel. Particularly advantageous is the attachment already at the very front of the device to prevent the formation of bacteria and germs early or already existing or flushed bacteria and Kill germs.
  • the UV light source can be placed immediately behind the safety valve.
  • the pH of the liquids flowing through the device-analyte or complexing agent-could also be adjusted so that nucleation is prevented or existing bacteria and germs are killed.
  • a computer can be arranged in the housing, which is preferably designed as a PC. With such a computer, the entire device can be controlled. In addition, an evaluation of the measurement results can be made with the computer.
  • the computer can be realized in an advantageous manner as a so-called “embedded” computer with a suitable interface in order, for example, to allow integration into a network in a frame, preferably in a 19-inch frame, Such frames allow a secure arrangement of the housing during operation of the device and thus good accessibility for an operator.
  • a compact inline measuring unit is realized, which can be used in a particularly advantageous manner in a wide variety of analysis applications.
  • flow rates through the microchannel of a few ⁇ / min are common.
  • an automated analysis device for the continuous detection of, for example, metal ions in a sub-ppb range is also realized.
  • a preferably spiral-shaped microchannel With a length of several meters, impurities in the smallest concentrations in aqueous solutions can be detected spectrometrically.
  • light is coupled into a channel flushed with the analyte and guided by total reflection over the longest possible path to achieve a measurable extinction even at very low ion concentrations.
  • FIG. 1 is a schematic representation of an embodiment of the inventive device for inline trace analysis of a liquid
  • Fig. 2 in detail a portion of the device according to the invention for
  • Fig. 1 shows a schematic representation of an embodiment of an inventive device for inline trace analysis of a liquid.
  • the device has a housing 1 to allow safe and easy handling of the device as an inline measuring device in different industrial areas.
  • One application is the semiconductor industry, where the device can monitor and analyze aqueous process solutions in real time and continuously.
  • the device has a microchannel 2 which is etched as a spiral optical waveguide into a silicon wafer.
  • the microchannel 2 is only schematic here represented by the designated by the reference numeral 2 component.
  • Such a microchannel with corresponding supply and coupling elements for liquid and light is described in detail in EP 2 486 388 B1.
  • the liquid to be examined is flowed through the microchannel 2 and, on the other hand, light is coupled in to a light source 3.
  • Light emerging from the microchannel 2 is analyzed by a detector 4.
  • the detector 4 can be designed for different spectrometric analyzes.
  • the detector 4 may be designed for a measurement of the extinction.
  • a user interface 5 is integrated into the housing 1.
  • This user interface can be realized, for example, by a display or touch panel.
  • the housing 1 has a connection 6.
  • the power supply of the device is provided via a connection 7. Suitable power supplies can be arranged in the housing 1.
  • the housing 1 In addition to the connection 6 for supplying the liquid, the housing 1 also has a connection 8 for discharging the liquid from the microchannel 2. Insofar, a flow operation with respect to the liquid to be examined is ensured with the device.
  • the device has at least one connection 18 for the supply of a rinsing solution.
  • a rinsing solution This allows the liquid circuit, in particular the microchannel 2, to be perfused from time to time with a suitable rinsing solution and thus cleaned. It is also possible to use several connections 18 for different rinsing solutions, for example an acid and an alkaline rinsing solution.
  • the device has a pump 19.
  • the pump 19 is here associated with the supply line 12, but can also be attached to other suitable locations. It is also possible to use a plurality of pumps 19. Particularly advantageous is the design of the pump 19 as a micropump, for example a micromembrane pump.
  • the device has a reference channel 9, which is formed quasi-parallel to the measuring channel 17 leading through the microchannel 2.
  • the reference channel 9 is formed by a rolled up from the light source 3 to the detector 4 rolled optical waveguide.
  • an attenuator 10 is assigned to the reference channel 9.
  • the signal in the reference channel 9 is attenuated before it enters the detector 4.
  • a switching device 11 in the form of, for example, a shutter is realized, so that only light from a channel - either from the measuring channel 17 or from the reference channel 9 - is directed to the detector 4.
  • a single-channel data acquisition simplifies the construction of the detector 4, for example, as a mere line detector.
  • the device may have appropriately arranged safety valves 20.
  • a feed line 12 for supplying and / or a discharge 13 for discharging the liquid and / or the microchannel 2 may be assigned a safety valve 20, which responds when a predeterminable pressure is exceeded or in the event of a leakage.
  • the housing 1 may be assigned a moisture sensor or leakage sensor 21.
  • a moisture sensor or leakage sensor 21 could be arranged in a collecting trough 22 for liquids, which may be located below the microchannel 2 or at a suitable point below a liquid-carrying supply line 12 or discharge line 13, for example.
  • the collecting trough 22 covers the entire liquid-conducting region within the housing 1, so that the leakage of liquid at any point from the moisture keits- or leakage sensor 21 is detected.
  • Such a moisture sensor or leakage sensor 21 may be associated with a shut-off device for the device and / or a pump 19 or piezo-membrane pump. In that regard, a safety shutdown upon leakage of liquid can be realized.
  • the safety valves 20 are actuated by the signal of the moisture or leakage sensor 21, so that the liquid supply into the housing 1 is stopped.
  • the embodiment of the device further comprises a degassing device 14 with a vacuum pump 23 to remove air bubbles and dissolved gases within the liquid.
  • the degassing device 14 is assigned to the supply line 12 in the embodiment shown here.
  • a flow measuring device 24 can be provided, which can be assigned to a supply line 12 and / or a discharge line 13 or the microchannel 2.
  • the device shown in FIG. 1 furthermore has a UV irradiation device 15 for irradiating UV light into the microchannel 2 in order to kill bacteria or germs formed in the microchannel 2.
  • the UV irradiation can be advantageously radiated away from the detector 4, via the half-transparent mirror 25, counter to the measuring direction by the microchannel 2 in order to deflect oxygen microbubbles from the inner wall of the microchannel 2. and to realize a germ killing or bacterial killing.
  • the UV light source 15 is made of, for example, a xenon flash lamp.
  • the device contains a further UV light source 26, for example a cold cathode lamp.
  • the UV light of this UV light source 26 is coupled immediately after the safety valve 20 in order to achieve as early as possible in the system killing of bacteria and germs.
  • the UV radiation may, for example, have a wavelength of 254 nm. This is a particularly effective wavelength in terms of germ killing.
  • a computer 16 is further arranged, which performs the entire control of the device and / or evaluation of the measurement results.
  • the computer has an interface 27, via which the device can be connected to a network.
  • FIG. 2 shows details of a partial region of the device according to the invention for inline trace analysis of a liquid.
  • the lead and some or all components contained therein are divided into two branches.
  • branch 6a of the feed the analyte is fed, i. the liquid containing the substances to be examined.
  • branch 6b of the supply line of the complexing agent is supplied, which reacts with the analyte, whereby the more easily detected complexes are formed.
  • the reference numerals in Fig. 2 correspond to those in Fig. 1 with the addition of the branch identifier a or b.
  • the two liquids are brought together in a mixer 28.
  • the mixer 28 may be a structured component, where an efficient mixing takes place. In a particularly simple manner, the mixer 28 simply consists of a coupling point, where the two liquids flow together.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Signal Processing (AREA)
  • Hydrology & Water Resources (AREA)
  • Engineering & Computer Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Dispositif d'analyse de traces en ligne d'un liquide, de préférence d'une solution aqueuse de traitement, comportant un boîtier (1), un micro-canal (2) dans lequel s'écoule le liquide à étudier et dans lequel est injectée de la lumière d'une source lumineuse (3), un détecteur (4) pour la lumière qui sort du micro-canal (2) et une interface utilisateur (5) pour surveiller et/ou commander ledit dispositif, le micro-canal (2), le détecteur (4) et/ou l'interface utilisateur (5) étant agencés et/ou intégrés dans le boîtier (1), et le boîtier (1) comprenant un raccord (6) pour un apport du liquide dans le microcanal (2) et une connexion (7) pour l'alimentation électrique du dispositif.
EP16706123.3A 2015-01-08 2016-01-07 Dispositif d'analyse de traces en ligne d'un liquide Withdrawn EP3243064A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102015200115 2015-01-08
DE102015218095.6A DE102015218095A1 (de) 2015-01-08 2015-09-21 Vorrichtung zur Inline-Spurenanalyse einer Flüssigkeit
PCT/DE2016/200000 WO2016110294A1 (fr) 2015-01-08 2016-01-07 Dispositif d'analyse de traces en ligne d'un liquide

Publications (1)

Publication Number Publication Date
EP3243064A1 true EP3243064A1 (fr) 2017-11-15

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Application Number Title Priority Date Filing Date
EP16706123.3A Withdrawn EP3243064A1 (fr) 2015-01-08 2016-01-07 Dispositif d'analyse de traces en ligne d'un liquide

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