EP3232914A1 - Method for monitoring the evolution of an indicator used to indicate the physical state of an individual, and monitoring device - Google Patents

Method for monitoring the evolution of an indicator used to indicate the physical state of an individual, and monitoring device

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Publication number
EP3232914A1
EP3232914A1 EP15821152.4A EP15821152A EP3232914A1 EP 3232914 A1 EP3232914 A1 EP 3232914A1 EP 15821152 A EP15821152 A EP 15821152A EP 3232914 A1 EP3232914 A1 EP 3232914A1
Authority
EP
European Patent Office
Prior art keywords
equipment
monitoring
biological fluid
subject
biomarker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15821152.4A
Other languages
German (de)
French (fr)
Inventor
Cyril TORRE
Matthieu SERGENT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lsee
Original Assignee
Lsee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lsee filed Critical Lsee
Publication of EP3232914A1 publication Critical patent/EP3232914A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4869—Determining body composition
    • A61B5/4872—Body fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Definitions

  • the present invention is in the field of methods for monitoring the metabolism of a subject and associated connected devices.
  • the invention is also part of the devices for controlling his diet.
  • Obesity has become a major public health problem. It is defined by an abnormal or excessive accumulation of body fat which represents a risk to health and deteriorates the quality of life. Obesity is a major risk factor for diabetes, cardiovascular disease or cancer. In 2014, 1.4 billion adults were overweight, resulting in 3.4 million deaths worldwide each year. Formerly reserved for rich countries, it also progresses drastically in emerging countries.
  • Obesity is mainly due to an imbalance between an excess food intake and insufficient energy expenditure.
  • Food is a fundamental vector of the health status of individuals. However, its importance in medical practices is underestimated or even misunderstood. Multiple solutions have been developed to combat obesity such as diets, coaching, sports, diet pills, surgery, appetite suppressants ... But often, their use results in failures due to their maladjustment. to the individual in particular.
  • the present invention proposes to allow the greatest number to be able to follow his metabolism in order to guide his choice of diet and physical activity according to the goal he has set.
  • US2003 / 0223905 patent application relates to a weight loss system and a method measuring one or more metabolic parameters in a body fluid sample and correlating the level of the metabolic parameter to a change in body fat level and a metabolic stage. .
  • This system makes it possible to qualify the energy balance of the subject, the energy balance being understood as the amount of energy ingested compared to the amount of energy expended by tracing a marker of lipolysis as a ketone body, glycerol or a fatty acid free.
  • WO2009 / 131664 a metabolic energy monitoring system comprising physiological parameter measurement platforms for calculating an energy equilibrium on the basis of the caloric intake and the energy spent. This device is preferably permanently worn on the body for continuous measurement.
  • Metabolic activity is a combination of different parameters, the monitoring of which can not be limited to monitoring the body fat mass and its evolution.
  • the devices of the prior art focus on the quantification of energy in the form of calories spent and ingested in order to formulate recommendations to the user, this quantification relying on algorithms that do not take into account metabolic specificities. specific to the individual.
  • the present invention proposes, according to its most general acceptance, a method of monitoring the evolution of a physical status indicator comprising the fat mass of a subject and / or the muscle mass of a patient. subject, including periodic steps method of analyzing a biological fluid for quantifying a biomarker representative of a metabolic activity including lipolysis, myolysis, lipogenesis or myogenesis and transmitting the result of said analysis to a remote connected equipment.
  • the present invention allows a metabolism monitoring of a subject over a period of time given a frequency at the free choice of the user.
  • the user can first use the invention to understand his metabolism and correlate his eating habits, behavioral and physical activity to a measured degree of metabolism, for example lipolysis or myolysis.
  • the user can capitalize the data in order to establish a repository allowing him to be his own witness and thus to be able to adapt his diet or practice the appropriate physical activity according to the chosen target.
  • the present invention therefore has the advantage that the control values are directly related to the individual by the constitution of this frame of reference and not to standards or methods of calculating the energy spent according to generally accepted methods.
  • the method according to the invention comprises:
  • the method may further comprise an identification step among this individual reference of the physical activity, the food habit and / or behavior most appropriate to the objective that the subject has set.
  • This objective can be a muscular mass to achieve, a body weight to reach, a fat mass to be reduced, a metabolic activity to maintain ...
  • the invention is part of personalized medicine, placing food at the center of the health and well-being of the individual and by easily studying objectively measurable, quantifiable and correlable parameters to the intensity of the metabolism, particularly lipolysis. , myolysis and their counterparts lipogenesis and myogenesis.
  • the biomarker is understood as circulating molecules and / or found in a biological fluid selected from blood, urine, sweat, saliva or tears.
  • a biological fluid selected from blood, urine, sweat, saliva or tears.
  • the biological fluid is urine or blood according to embodiments.
  • biomarkers can be byproducts of muscle breakdown and / or body fat.
  • concentration of these biomarkers varies according to the metabolism of the subject, reflecting the lipid metabolism (lipolysis / lipogenesis) or the muscular metabolism (myolysis / myogenesis).
  • the biomarker detected in the urine is chosen from glycerol, carnitine, acylcarnitine, a ketone body, beta aminoisobutyrate, a marker of inflammation and their metabolites.
  • the biomarker detected in the blood is chosen from free fatty acids, glycerol, carnitine, acylcarnitine, a ketone body, beta aminoisobutyrate, a marker of inflammation and their metabolites.
  • the marker of the inflammation detected in the biological fluid is an interleukin, preferentially interleukin 6.
  • the invention also relates to equipment for implementing the method according to the invention.
  • the equipment comprises a means for analyzing a biological fluid for the quantification of a biomarker, a local clock and a computer executing a computer program for controlling said analysis means, the processing of the information provided by the means of analysis. analysis, recording in local memory, and communication with connected equipment.
  • the means for analyzing a biological fluid comprise means for receiving the biological liquid such as a reservoir or an absorbent material. These reception means can be coupled to biosensors to quantify the biomarker, such as antibodies or enzymes.
  • These receiving means, coupled or not with biosensors may be disposable or cleanable. Preferably they are for single use.
  • the equipment comprises data communication means with a remote connected equipment, preferably wireless communication means such as bluetooth, wifi, internet or infrared.
  • a remote connected equipment preferably wireless communication means such as bluetooth, wifi, internet or infrared.
  • the invention relates to a system for monitoring a physical status indicator comprising the fat mass of a subject and / or the muscle mass of a subject, the system comprising at least one equipment such as defined above and at least one connected equipment, in particular a tablet or a cellular telephone, as well as a computer application controlling the operation of said connected equipment for communication with said equipment, the local and / or remote recording of the results of the periodic analyzes, viewing a graphical information calculated according to a plurality of recorded analyzes.
  • the invention relates to a computer program for controlling equipment connected to equipment as defined above, the computer program controlling the communication between the connected equipment and the analysis equipment. , recording in a memory of the connected equipment or a remote server time-stamped data and where appropriate geolocated and the display on a screen of the connected equipment of a graphical information calculated according to a plurality of saved analyzes.
  • the device according to the invention makes it possible to measure one or more biomarkers, in the blood or in the urine.
  • the device can measure in the blood either glycerol or beta-aminoisobutyrate or interleukin 6 or a combination thereof.
  • the device makes it possible to measure the concentration of glycerol in the blood.
  • the user measures a glycerol concentration of 0.3 mmol / L at rest and a concentration of 1 mmol / L after one hour of cycling at a moderate pace.
  • These physical activities can for example be walking, running, swimming or any other physical activity.
  • the user thus creates an individual repository.
  • the user measures a concentration of beta- aminoisobutyrate of 1.8 ⁇ mol / L and a beta-aminoisobutyrate concentration of 2.7 ⁇ mol / L after one hour of moderate speed cycling.
  • the user thus creates an individual repository. It compares the values obtained after different physical activities and identifies the most adapted to its metabolism to stimulate the degradation of its fat mass and / or to stimulate the synthesis of its muscular mass.
  • the user measures a concentration of interleukin 6 at 10 ng / L at rest and an interleukin 6 concentration of 120 ng / L after one hour of moderate speed cycling.
  • Biomarker measurement data are recorded.
  • the raw parameters measured are used to establish a scale of intensity representative of the metabolic activity (lipolysis, myolysis ).
  • An arbitrary unit is assigned and a color scale representing intensity (ranging from red for very low lipolysis, to green for high intensity) is generated.
  • the equipment includes an electronic biosensor for quantifying the biomarker of interest in the biological fluid.
  • the user places a sample of a biological fluid on a strip of polymers on which biosensors are attached. Then the user disposes the strip in the biodetector.
  • the biodetector measures the biomarker concentration in the biological sample and records it. The user can then choose to send the measurement on a computer type equipment, mobile phone, tablet by bluetooth.
  • the strip is disposable after use. It has the appropriate biosensors according to the biomarker to be quantified.
  • the measurement received for example by the user's phone is integrated into an application that will process it. The user can then visualize his physical state at the time of measurement. After an effort, the user performs the same manipulation again and compares the results.
  • the user builds his own database in order to correlate his physical condition with the food he has consumed and his physical activity.
  • This database constitutes its individual reference system.
  • the user thanks to the invention, knows the impact on his metabolism of a particular food habit or of such or such intensity of physical activity. It therefore has a visibility on the practices to implement to achieve its objective, for example a given weight or a given muscle mass.
  • the user can also follow the evolution of his progress to reach the goal he has set.
  • the user can also combine in this application other parameters from other devices connected such as a connected scale to follow the evolution curve of its weight, and also its body fat.
  • the application also offers recommendations based on the user's repository according to the objective he has set.
  • the user can follow in real time the evolution of his physical state according to the goal he has set and especially adapt the diet and physical intensity according to this goal to achieve.
  • the invention therefore makes it possible to strongly motivate the user since the latter visualizes concretely and in real time his progress with respect to the objective.
  • FIG. 1 shows the block diagram of an equipment (1) according to a particular embodiment of the present invention. It includes a microcomputer (2) capable of executing computer instructions and data processing.
  • This microcomputer (2) comprises a microprocessor (3) which can be of any type known from the state of the art.
  • the microcomputer (2) also comprises a storage unit (4) capable of receiving a computer program defining a set of instructions specific to the implementation of the method, and storing data.
  • a battery (7) provides power to the electrical and electronic circuits of the equipment.
  • the equipment (1) also comprises a detector
  • the equipment (1) also includes an input-output interface (6) connected to the microcomputer (120) for communication with associated equipment (20), for example a tablet or cell phone.
  • the input-output interface (6) may be of wired type allowing the connection with the associated equipment (20) by a cord having a connector adapted to the associated equipment (20).
  • the input-output interface (6) is rather of the radio frequency type, for example of the Bluetooth type.
  • the establishment of the connection begins with an inquisition phase, during which the computer program stored in the memory (4) commands the sending of an inquisition request to all devices present in the range, called access points. All devices receiving the request respond with their address.
  • the equipment (1) selects an address previously registered or selected by the user and synchronizes with the access point according to a technique called paging, consisting of synchronizing its clock and its frequency with the access point.
  • paging consisting of synchronizing its clock and its frequency with the access point.
  • a link is then established with the access point, allowing the equipment (1) to begin a phase of discovery of the services of the access point, according to a protocol called SDP (Service Discovery Protocol).
  • SDP Service Discovery Protocol
  • the master device is able to create a communication channel with the access point using the L2CAP protocol.
  • an additional RFCOMM channel operating over the L2CAP channel is established to provide a virtual serial port.
  • the associated equipment (20) integrates a pairing security mechanism (in English pairing), allowing to restrict access only to authorized users in order to guarantee a certain level of tightness of the piconet.
  • the pairing is done using an encryption key commonly called "PIN" (Personal Information Number).
  • PIN Personal Information Number
  • the associated equipment (20) sends a pairing request to the master device. This can most often trigger a user intervention to enter the access point PIN. If the received PIN is correct, the association takes place.
  • the PIN will be transmitted encrypted using a second key, to avoid any risk of compromise.
  • the associated equipment (20) is free to use the communication channel thus established in order to retrieve the data stored in the memory (4) of the equipment (1), and then to provide communication with a remote server via a digital telecommunication network (eg Internet) preferentially in a secure manner.
  • a remote server records the data provided by the equipment (1) by associating them with time stamping and / or geolocation data coming from the associated equipment (20), in order to constitute a database of historical data of the equipment (1).
  • user identified by the equipment (1) and perform processing to provide data representative of the evolution of an indicator of the physical state of this user.
  • the server returns the result of the analysis to the user via the same network or another.
  • the server stores the data and / or the result of the analysis on a means of recording.
  • the equipment (1) allows the registration of an identifier of a user, or a plurality of identifiers each corresponding to a given user.
  • This identifier is used by the associated equipment (20) to establish the connection with the server and to allow the setting of the personal data of the user, in an application loaded into the memory of the associated equipment (20) and on the remote server.

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Abstract

The invention relates to a method for monitoring the evolution of an indicator used to indicate physical state comprising the body fat of a subject and/or the muscular mass of a subject, comprising periodical steps of analysis of a biological fluid for the quantification of a biomarker representative of a metabolic activity comprising lipolysis, myolysis, lipogenesis or myogenesis, and of transmission of the result of said analysis to a remote connected apparatus.

Description

PROCEDE DE MONITORING DE L'EVOLUTION D'UN INDICATEUR D'ETAT PHYSIQUE D'UN INDIVIDU ET DISPOSITIF DE MONITORING  METHOD FOR MONITORING THE EVOLUTION OF A PHYSICAL STATUS INDICATOR OF AN INDIVIDUAL AND MONITORING DEVICE
Domaine de 1 ' invention Field of the invention
La présente invention se place dans le domaine des méthodes de suivi du métabolisme d'un sujet et des dispositifs connectés associés. L'invention s'inscrit également dans le cadre des dispositifs pour maîtriser son régime alimentaire. The present invention is in the field of methods for monitoring the metabolism of a subject and associated connected devices. The invention is also part of the devices for controlling his diet.
Contexte de l'invention Context of the invention
L'obésité est devenue un problème majeur de santé publique. Elle se définit par une accumulation anormale ou excessive de graisse corporelle qui représente un risque pour la santé et détériore la qualité de vie. L'obésité est un facteur de risque majeur pour le diabète, les maladies cardio- vasculaires ou le cancer. En 2014, 1,4 milliard d'adultes étaient en surpoids entraînant 3,4 millions de décès dans le monde par an. Autrefois réservée aux pays riches, elle progresse également drastiquement dans les pays émergents. Obesity has become a major public health problem. It is defined by an abnormal or excessive accumulation of body fat which represents a risk to health and deteriorates the quality of life. Obesity is a major risk factor for diabetes, cardiovascular disease or cancer. In 2014, 1.4 billion adults were overweight, resulting in 3.4 million deaths worldwide each year. Formerly reserved for rich countries, it also progresses drastically in emerging countries.
L'obésité est principalement due à un déséquilibre entre un apport alimentaire excédentaire et des dépenses énergétiques insuffisantes.  Obesity is mainly due to an imbalance between an excess food intake and insufficient energy expenditure.
L'alimentation est un vecteur fondamental de l'état de santé des individus. Or son importance dans les pratiques médicales est sous-estimée voire mal comprise. De multiples solutions ont été développées pour lutter contre l'obésité comme les régimes, le coaching, le sport, les pilules amaigrissantes, la chirurgie, les coupe-faim... Or souvent, leur utilisation se solde par des échecs dus à leur inadaptation à l'individu en particulier.  Food is a fundamental vector of the health status of individuals. However, its importance in medical practices is underestimated or even misunderstood. Multiple solutions have been developed to combat obesity such as diets, coaching, sports, diet pills, surgery, appetite suppressants ... But often, their use results in failures due to their maladjustment. to the individual in particular.
Ces dernières années, le concept de médecine personnalisée a émergé. Celle-ci a pour but de traiter l'individu en intégrant l'ensemble de ses données biologiques et de ses particularités physiologiques individuelles. La médecine personnalisée s'est naturellement étendue à la nutrition, remettant l'alimentation au centre des préoccupations. L'alimentation personnalisée basée sur le métabolisme de l'individu était historiquement réservée aux sportifs de haut niveau afin d'optimiser leurs performances physiques. Ceci impliquait un suivi très lourd des changements métaboliques, notamment par des examens invasifs allant de la prise de sang à la biopsie en passant par la microdialyse. In recent years, the concept of personalized medicine has emerged. It aims to treat the individual by integrating all of his biological data and its individual physiological peculiarities. Personalized medicine has naturally extended to nutrition, putting food at the center of attention. The personalized diet based on the metabolism of the individual was historically reserved for top athletes to optimize their physical performance. This implied a very heavy follow-up of the metabolic changes, in particular by invasive examinations ranging from blood sampling to biopsy via microdialysis.
La présente invention se propose de permettre au plus grand nombre de pouvoir suivre son métabolisme afin d'orienter ses choix d'alimentation et d'activité physique en fonction de l'objectif qu'il s'est fixé. Etat de la technique  The present invention proposes to allow the greatest number to be able to follow his metabolism in order to guide his choice of diet and physical activity according to the goal he has set. State of the art
L'on connaît de l'art antérieur des objets connectés qui permettent de suivre par exemple le poids d'un individu ou l'effort qu'il fournit. Il s'agit notamment des balances ou bracelets connectés qui donnent à l'utilisateur la possibilité de suivre un ou plusieurs paramètres comme le poids, sa dépense énergétique, son sommeil, son rythme cardiaque... Connected objects are known from the prior art and make it possible to follow, for example, the weight of an individual or the effort he provides. These include scales or connected bracelets that give the user the ability to follow one or more parameters such as weight, energy expenditure, sleep, heart rate ...
La demande de brevet US2003/0223905 porte sur un système de perte de poids et une méthode mesurant un ou plusieurs paramètres métaboliques dans un échantillon de fluide corporel et corrélant le niveau du paramètre métabolique à un changement du niveau de graisse corporelle et à un stade métabolique. Ce système permet de qualifier la balance énergétique du sujet, la balance énergétique se comprenant comme la quantité d'énergie ingérée par rapport à la quantité d'énergie dépensée en traçant un marqueur de la lipolyse comme un corps cétonique, le glycérol ou un acide gras libre. Il est également connu de l'art antérieur dans la demande de brevet W02009/ 131664 un système de suivi de l'énergie métabolique comprenant des plateformes de mesure de paramètres physiologiques pour calculer un équilibre énergétique sur la base de la prise calorique et de l'énergie dépensée. Ce dispositif est préférentiellement porté en permanence sur le corps pour une mesure en continu. US2003 / 0223905 patent application relates to a weight loss system and a method measuring one or more metabolic parameters in a body fluid sample and correlating the level of the metabolic parameter to a change in body fat level and a metabolic stage. . This system makes it possible to qualify the energy balance of the subject, the energy balance being understood as the amount of energy ingested compared to the amount of energy expended by tracing a marker of lipolysis as a ketone body, glycerol or a fatty acid free. It is also known from the prior art in the patent application WO2009 / 131664 a metabolic energy monitoring system comprising physiological parameter measurement platforms for calculating an energy equilibrium on the basis of the caloric intake and the energy spent. This device is preferably permanently worn on the body for continuous measurement.
Inconvénients de l'art antérieur Disadvantages of prior art
Les solutions de l'art antérieur présentent l'inconvénient de se centrer sur la perte de poids en s 'attachant à refléter uniquement la masse de graisse corporelle par rapport à la balance énergétique calculée. The solutions of the prior art have the disadvantage of focusing on weight loss by attaching themselves to reflect only the mass of body fat compared to the calculated energy balance.
Or l'activité métabolique est une combinaison de différents paramètres dont le suivi ne peut se limiter au seul suivi de la masse de graisse corporelle et de son évolution.  Metabolic activity is a combination of different parameters, the monitoring of which can not be limited to monitoring the body fat mass and its evolution.
Par ailleurs, les dispositifs de l'art antérieur se focalisent sur la quantification d'énergie sous forme de calories dépensées et ingérées afin de formuler des préconisations à l'utilisateur, cette quantification reposant sur des algorithmes qui ne prennent pas en compte les spécificités métaboliques propres à l'individu.  Moreover, the devices of the prior art focus on the quantification of energy in the form of calories spent and ingested in order to formulate recommendations to the user, this quantification relying on algorithms that do not take into account metabolic specificities. specific to the individual.
Or ces préconisations ne sont pas forcément adaptées car elles se basent sur des concepts généraux qui ne découlent pas directement de l'étude des besoins métaboliques et des spécificités métaboliques individuelles.  These recommendations are not necessarily adapted because they are based on general concepts that do not derive directly from the study of metabolic needs and individual metabolic specificities.
Solution apportée par l'invention Solution provided by the invention
Afin de remédier à ces inconvénients, la présente invention propose selon son acceptation la plus générale un procédé de monitoring de l'évolution d'un indicateur d'état physique comprenant la masse graisseuse d'un sujet et/ou la masse musculaire d'un sujet, comprenant des étapes périodiques d'analyse d'un liquide biologique pour la quantification d'un biomarqueur représentatif d'une activité métabolique comprenant la lipolyse, la myolyse, la lipogenèse ou la myogenèse et de transmission du résultat de ladite analyse à un équipement connecté distant. In order to remedy these drawbacks, the present invention proposes, according to its most general acceptance, a method of monitoring the evolution of a physical status indicator comprising the fat mass of a subject and / or the muscle mass of a patient. subject, including periodic steps method of analyzing a biological fluid for quantifying a biomarker representative of a metabolic activity including lipolysis, myolysis, lipogenesis or myogenesis and transmitting the result of said analysis to a remote connected equipment.
L'on comprend que la présente invention permet un suivi du métabolisme d'un sujet sur une période de temps donné à une fréquence au libre choix de l'utilisateur. L'utilisateur peut dans un premier temps utiliser l'invention pour comprendre son métabolisme et corréler ses habitudes alimentaires, comportementales et son activité physique à un degré de métabolisme mesuré, par exemple la lipolyse ou la myolyse. L'utilisateur peut capitaliser les données afin d'en établir un référentiel lui permettant d'être son propre témoin et ainsi de pouvoir adapter son alimentation ou pratiquer l'activité physique adaptée en fonction de la cible choisie. La présente invention présente donc l'avantage que les valeurs témoins sont directement liées à l'individu par la constitution de ce référentiel et non à des référentiels ou des méthodes de calcul de l'énergie dépensée en fonction de méthodes globalement admises .  It is understood that the present invention allows a metabolism monitoring of a subject over a period of time given a frequency at the free choice of the user. The user can first use the invention to understand his metabolism and correlate his eating habits, behavioral and physical activity to a measured degree of metabolism, for example lipolysis or myolysis. The user can capitalize the data in order to establish a repository allowing him to be his own witness and thus to be able to adapt his diet or practice the appropriate physical activity according to the chosen target. The present invention therefore has the advantage that the control values are directly related to the individual by the constitution of this frame of reference and not to standards or methods of calculating the energy spent according to generally accepted methods.
L'on comprend que le procédé selon l'invention comprend :  It is understood that the method according to the invention comprises:
des étapes périodiques d'analyse d'un liquide biologique pour la quantification d'un biomarqueur représentatif de l'activité métabolique comprenant la lipolyse, la myolyse, la lipogenèse et la myogenèse, ladite analyse étant réalisée avant, pendant et/ou après une activité physique, une habitude alimentaire et/ou un comportement donnés  periodic steps of analyzing a biological fluid for quantifying a biomarker representative of the metabolic activity including lipolysis, myolysis, lipogenesis and myogenesis, said analysis being performed before, during and / or after an activity physical, a given eating habit and / or behavior
la transmission du résultat de ladite analyse à un équipement connecté distant  transmitting the result of said analysis to a remote connected equipment
l'établissement d'un référentiel individuel du sujet corrélant une activité physique, une habitude alimentaire et/ou un comportement à la quantification dudit biomarqueur the establishment of an individual reference of the subject correlating a physical activity, a habit food and / or behavior to quantify said biomarker
la comparaison de la quantification d'un biomarqueur au référentiel individuel.  the comparison of the quantification of a biomarker to the individual frame of reference.
Le procédé peut comprendre en outre une étape d'identification parmi ce référentiel individuel de l'activité physique, de l'habitude alimentaire et/ou d'un comportement le plus approprié par rapport à l'objectif que le sujet s'est fixé. Cet objectif peut être une masse musculaire à atteindre, un poids corporel à atteindre, une masse graisseuse à diminuer, une activité métabolique à maintenir...  The method may further comprise an identification step among this individual reference of the physical activity, the food habit and / or behavior most appropriate to the objective that the subject has set. This objective can be a muscular mass to achieve, a body weight to reach, a fat mass to be reduced, a metabolic activity to maintain ...
L'on comprend qu'après avoir construit son propre référentiel individuel, le sujet peut comparer ses performances ultérieures et suivre son activité métabolique.  It is understood that after having constructed its own individual reference system, the subject can compare his subsequent performances and follow his metabolic activity.
Ainsi l'invention s'inscrit dans la médecine personnalisée plaçant l'alimentation au centre de la santé et du bien-être de l'individu et en étudiant facilement des paramètres objectivement mesurables, quantifiables et corrélables à l'intensité du métabolisme, particulièrement lipolyse, myolyse et leurs pendants lipogenèse et myogenèse.  Thus the invention is part of personalized medicine, placing food at the center of the health and well-being of the individual and by easily studying objectively measurable, quantifiable and correlable parameters to the intensity of the metabolism, particularly lipolysis. , myolysis and their counterparts lipogenesis and myogenesis.
Le biomarqueur se comprend comme des molécules circulantes et/ou se retrouvant dans un liquide biologique choisi parmi le sang, les urines, la sueur, la salive ou les larmes. Avantageusement, le liquide biologique est l'urine ou le sang selon des modes de réalisation. The biomarker is understood as circulating molecules and / or found in a biological fluid selected from blood, urine, sweat, saliva or tears. Advantageously, the biological fluid is urine or blood according to embodiments.
Ces biomarqueurs peuvent être des sous-produits de la dégradation des muscles et/ou de la graisse corporelle. La concentration de ces biomarqueurs varie selon le métabolisme du sujet, reflétant le métabolisme lipidique (lipolyse/ lipogenèse) ou le métabolisme musculaire (myolyse/myogenèse ) .  These biomarkers can be byproducts of muscle breakdown and / or body fat. The concentration of these biomarkers varies according to the metabolism of the subject, reflecting the lipid metabolism (lipolysis / lipogenesis) or the muscular metabolism (myolysis / myogenesis).
Selon un mode de réalisation, le biomarqueur détecté dans les urines est choisi parmi le glycérol, la carnitine, 1 ' acylcarnitine , un corps cétonique, le béta aminoisobutyrate , un marqueur de l'inflamma ion et leurs métabolites . According to one embodiment, the biomarker detected in the urine is chosen from glycerol, carnitine, acylcarnitine, a ketone body, beta aminoisobutyrate, a marker of inflammation and their metabolites.
Selon un autre mode de réalisation, le biomarqueur détecté dans le sang est choisi parmi les acides gras libres, le glycérol, la carnitine, 1 'acylcarnitine, un corps cétonique, le béta aminoisobutyrate, un marqueur de l'inflammation et leurs métabolites. Selon un mode particulier de réalisation, le marqueur de l'inflammation détecté dans le liquide biologique est une interleukine, préférentiellement 1 ' interleukine 6. According to another embodiment, the biomarker detected in the blood is chosen from free fatty acids, glycerol, carnitine, acylcarnitine, a ketone body, beta aminoisobutyrate, a marker of inflammation and their metabolites. According to a particular embodiment, the marker of the inflammation detected in the biological fluid is an interleukin, preferentially interleukin 6.
L'invention porte également sur un équipement pour la mise en œuvre du procédé selon l'invention. L'équipement comporte un moyen d'analyse d'un liquide biologique pour la quantification d'un biomarqueur, une horloge locale et un calculateur exécutant un programme informatique pour le pilotage dudit moyen d'analyse, le traitement des informations fournies par le moyen d'analyse, l'enregistrement dans une mémoire locale, et la communication avec un équipement connecté . The invention also relates to equipment for implementing the method according to the invention. The equipment comprises a means for analyzing a biological fluid for the quantification of a biomarker, a local clock and a computer executing a computer program for controlling said analysis means, the processing of the information provided by the means of analysis. analysis, recording in local memory, and communication with connected equipment.
Les moyens d'analyse d'un liquide biologique comportent des moyens de réception du liquide biologique tel qu'un réservoir ou un matériau absorbant. Ces moyens de réception peuvent être couplés à des biocapteurs pour pouvoir quantifier le biomarqueur, tels que des anticorps ou des enzymes .  The means for analyzing a biological fluid comprise means for receiving the biological liquid such as a reservoir or an absorbent material. These reception means can be coupled to biosensors to quantify the biomarker, such as antibodies or enzymes.
Ces moyens de réception, couplés ou pas avec des biocapteurs peuvent être à usage unique ou nettoyables. Préférentiellement ils sont à usage unique.  These receiving means, coupled or not with biosensors may be disposable or cleanable. Preferably they are for single use.
L'équipement comporte des moyens de communication des données avec un équipement connecté distant, de préférence des moyens de communication sans fil tels que bluetooth, wifi, internet ou infrarouge. Selon un autre aspect, l'invention porte sur un système pour le monitoring d'un indicateur d'état physique comprenant la masse graisseuse d'un sujet et/ou la masse musculaire d'un sujet, le système comprenant au moins un équipement comme défini précédemment et au moins un équipement connecté, notamment une tablette ou un téléphone cellulaire, ainsi qu'une application informatique commandant le fonctionnement dudit équipement connecté pour la communication avec ledit équipement, l'enregistrement local et/ou distant des résultats des analyses périodiques, la visualisation d'une information graphique calculée en fonction d'une pluralité d'analyse enregistrées. Selon un autre aspect, l'invention porte sur un programme d'ordinateur pour le pilotage d'un équipement connecté à un équipement comme défini précédemment, le programme d'ordinateur commandant la communication entre l'équipement connecté et l'équipement d'analyse, l'enregistrement dans une mémoire de l'équipement connecté ou un serveur distant des données horodatées et le cas échéant géolocalisées et l'affichage sur un écran de l'équipement connecté d'une information graphique calculée en fonction d'une pluralité d'analyses enregistrées. The equipment comprises data communication means with a remote connected equipment, preferably wireless communication means such as bluetooth, wifi, internet or infrared. According to another aspect, the invention relates to a system for monitoring a physical status indicator comprising the fat mass of a subject and / or the muscle mass of a subject, the system comprising at least one equipment such as defined above and at least one connected equipment, in particular a tablet or a cellular telephone, as well as a computer application controlling the operation of said connected equipment for communication with said equipment, the local and / or remote recording of the results of the periodic analyzes, viewing a graphical information calculated according to a plurality of recorded analyzes. According to another aspect, the invention relates to a computer program for controlling equipment connected to equipment as defined above, the computer program controlling the communication between the connected equipment and the analysis equipment. , recording in a memory of the connected equipment or a remote server time-stamped data and where appropriate geolocated and the display on a screen of the connected equipment of a graphical information calculated according to a plurality of saved analyzes.
Description Description
L'invention sera mieux comprise à l'aide de la description d'exemples non limitatifs de réalisation. The invention will be better understood with the aid of the description of nonlimiting examples of embodiment.
Le dispositif selon l'invention permet de mesurer un ou plusieurs biomarqueurs, dans le sang ou les urines. Dans les exemples ci-dessous, le dispositif peut mesurer dans le sang, soit le glycérol, soit le béta-aminoisobutyrate, soit 1 ' interleukine 6 soit une combinaison de ceux-ci. The device according to the invention makes it possible to measure one or more biomarkers, in the blood or in the urine. In the examples below, the device can measure in the blood either glycerol or beta-aminoisobutyrate or interleukin 6 or a combination thereof.
Mesure du glycérol dans le sang : Measurement of glycerol in the blood:
Dans cet exemple de réalisation, le dispositif permet de mesurer la concentration de glycérol dans le sang. L'utilisateur mesure une concentration de glycérol de 0,3 mmol/L au repos et une concentration de 1 mmol/L après une heure de vélo à allure modérée.  In this exemplary embodiment, the device makes it possible to measure the concentration of glycerol in the blood. The user measures a glycerol concentration of 0.3 mmol / L at rest and a concentration of 1 mmol / L after one hour of cycling at a moderate pace.
L'utilisateur réitère cette mesure avant et après des activités physiques différentes. Ces activités physiques peuvent par exemple être de la marche à pied, de la course à pied, de la natation ou tout autre activité physique. The user reiterates this measure before and after different physical activities. These physical activities can for example be walking, running, swimming or any other physical activity.
L'utilisateur se constitue ainsi un référentiel individuel. The user thus creates an individual repository.
Il compare les valeurs obtenues après différentes activités physiques et identifie la plus adaptée à son métabolisme pour stimuler la dégradation de sa masse graisseuse et/ou stimuler la synthèse de sa masse musculaire.  It compares the values obtained after different physical activities and identifies the most adapted to its metabolism to stimulate the degradation of its fat mass and / or to stimulate the synthesis of its muscular mass.
Mesure de béta-aminoisobutyrate dans le sang : Measurement of beta-aminoisobutyrate in the blood:
L'utilisateur mesure une concentration de beta- aminoisobutyrate de 1,8 umol/L et une concentration de beta- aminoisobutyrate de 2,7 umol/L après une heure de vélo à allure modérée .  The user measures a concentration of beta- aminoisobutyrate of 1.8 μmol / L and a beta-aminoisobutyrate concentration of 2.7 μmol / L after one hour of moderate speed cycling.
L'utilisateur réitère cette mesure avant et après des activités physiques différentes. Ces activités physiques peuvent par exemple être de la marche à pied, de la course à pied, de la natation ou tout autre activité physique. L'utilisateur se constitue ainsi un référentiel individuel. Il compare les valeurs obtenues après différentes activités physiques et identifie la plus adaptée à son métabolisme pour stimuler la dégradation de sa masse graisseuse et/ou stimuler la synthèse de sa masse musculaire. The user reiterates this measure before and after different physical activities. These physical activities may for example be walking, running or running. foot, swimming or any other physical activity. The user thus creates an individual repository. It compares the values obtained after different physical activities and identifies the most adapted to its metabolism to stimulate the degradation of its fat mass and / or to stimulate the synthesis of its muscular mass.
Mesure d'un marqueur de l'inflammation, 1 ' interleukine 6 dans le sang : Measurement of a marker of inflammation, interleukin 6 in the blood:
L'utilisateur mesure une concentration d ' interleukine 6 de 10 ng/L au repos et une concentration d ' interleukine 6 de 120 ng/L après une heure de vélo à allure modérée .  The user measures a concentration of interleukin 6 at 10 ng / L at rest and an interleukin 6 concentration of 120 ng / L after one hour of moderate speed cycling.
L'utilisateur réitère cette mesure avant et après des activités physiques différentes. Ces activités physiques peuvent par exemple être de la marche à pied, de la course à pied, de la natation ou tout autre activité physique. L'utilisateur se constitue ainsi un référentiel individuel.  The user reiterates this measure before and after different physical activities. These physical activities can for example be walking, running, swimming or any other physical activity. The user thus creates an individual repository.
Il compare les valeurs obtenues après différentes activités physiques et identifie la plus adaptée à son métabolisme pour stimuler la dégradation de sa masse graisseuse et/ou stimuler la synthèse de sa masse musculaire.  It compares the values obtained after different physical activities and identifies the most adapted to its metabolism to stimulate the degradation of its fat mass and / or to stimulate the synthesis of its muscular mass.
Compilation des données mesurées : Compilation of the measured data:
Les données de mesure de biomarqueurs sont enregistrées .  Biomarker measurement data are recorded.
Concernant les indicateurs figurant sur l'application, les paramètres bruts mesurés (et notamment la valeur au repos) servent à établir une échelle d'intensité représentative de l'activité métabolique (lipolyse, myolyse...). Une unité arbitraire est attribuée et une échelle de couleur représentant l'intensité (allant du rouge pour une lipolyse très faible, au vert pour une forte intensité) est générée . L'équipement comprend un biodétecteur électronique pour quantifier le biomarqueur d'intérêt dans le liquide biologique. Avant un effort, l'utilisateur place un échantillon d'un liquide biologique sur une bandelette de polymères sur laquelle des biocapteurs sont fixés. Puis l'utilisateur dispose la bandelette dans le biodétecteur. Le biodétecteur mesure la concentration du biomarqueur dans l'échantillon biologique et l'enregistre. L'utilisateur peut ensuite choisir d'envoyer la mesure sur un équipement de type ordinateur, téléphone portable, tablette par bluetooth. Concerning the indicators appearing on the application, the raw parameters measured (and in particular the value at rest) are used to establish a scale of intensity representative of the metabolic activity (lipolysis, myolysis ...). An arbitrary unit is assigned and a color scale representing intensity (ranging from red for very low lipolysis, to green for high intensity) is generated. The equipment includes an electronic biosensor for quantifying the biomarker of interest in the biological fluid. Before an effort, the user places a sample of a biological fluid on a strip of polymers on which biosensors are attached. Then the user disposes the strip in the biodetector. The biodetector measures the biomarker concentration in the biological sample and records it. The user can then choose to send the measurement on a computer type equipment, mobile phone, tablet by bluetooth.
La bandelette est jetable après utilisation. Elle comporte les biocapteurs adéquats en fonction du biomarqueur à quantifier . La mesure réceptionnée par exemple par le téléphone de l'utilisateur est intégrée dans une application qui va la traiter. L'utilisateur pourra ensuite visualiser son état physique au moment de la mesure. Après un effort, l'utilisateur effectue de nouveau la même manipulation et compare les résultats.  The strip is disposable after use. It has the appropriate biosensors according to the biomarker to be quantified. The measurement received for example by the user's phone is integrated into an application that will process it. The user can then visualize his physical state at the time of measurement. After an effort, the user performs the same manipulation again and compares the results.
L'utilisateur se constitue sa propre base de données afin de pouvoir corréler son état physique aux aliments qu'il a consommés et à son activité physique. Cette base de donnés constitue son référentiel individuel. L'utilisateur, grâce à l'invention, connaît l'impact sur son métabolisme de telle ou telle habitude alimentaire ou de telle ou telle intensité d'activité physique. Il a donc une visibilité sur les pratiques à mettre en œuvre pour atteindre son objectif, par exemple un poids donné ou une masse musculaire donnée. L'utilisateur peut également suivre l'évolution de sa progression pour atteindre l'objectif qu'il s'est fixé. The user builds his own database in order to correlate his physical condition with the food he has consumed and his physical activity. This database constitutes its individual reference system. The user, thanks to the invention, knows the impact on his metabolism of a particular food habit or of such or such intensity of physical activity. It therefore has a visibility on the practices to implement to achieve its objective, for example a given weight or a given muscle mass. The user can also follow the evolution of his progress to reach the goal he has set.
L'utilisateur peut également combiner dans cette application d'autres paramètres provenant d'autres dispositifs connectés comme par exemple une balance connectée afin de suivre la courbe d'évolution de son poids, et également de sa graisse corporelle. The user can also combine in this application other parameters from other devices connected such as a connected scale to follow the evolution curve of its weight, and also its body fat.
L'application propose également des préconisations en fonction du référentiel de l'utilisateur selon l'objectif qu'il s'est fixé.  The application also offers recommendations based on the user's repository according to the objective he has set.
L'utilisateur peut donc suivre en temps réel l'évolution de son état physique en fonction de l'objectif qu'il s'est fixé et surtout adapter l'alimentation et l'intensité physique en fonction de cet objectif à atteindre. L'invention permet par conséquent de fortement motiver l'utilisateur puisque ce dernier visualise concrètement et en temps réel ses progrès par rapport à l'objectif. Description d'un exemple non limitatif d'un équipement selon  The user can follow in real time the evolution of his physical state according to the goal he has set and especially adapt the diet and physical intensity according to this goal to achieve. The invention therefore makes it possible to strongly motivate the user since the latter visualizes concretely and in real time his progress with respect to the objective. Description of a non-limiting example of an equipment according to
1 ' invention  The invention
La figure 1 représente le schéma de principe d'un équipement (1) selon un mode de réalisation particulier de la présente invention. Il comprend un microcalculateur (2) capable d'exécuter des instructions informatiques et le traitement de données. Ce microcalculateur (2) comprend un microprocesseur (3) qui peut être de tout type connu de l'état de la technique. Le microcalculateur (2) comprend également une unité de stockage (4) apte à recevoir un programme d'ordinateur définissant un ensemble d'instructions propre à la mise en œuvre du procédé, et à stocker des données. Une batterie (7) assure l'alimentation des circuits électriques et électroniques de l'équipement. Figure 1 shows the block diagram of an equipment (1) according to a particular embodiment of the present invention. It includes a microcomputer (2) capable of executing computer instructions and data processing. This microcomputer (2) comprises a microprocessor (3) which can be of any type known from the state of the art. The microcomputer (2) also comprises a storage unit (4) capable of receiving a computer program defining a set of instructions specific to the implementation of the method, and storing data. A battery (7) provides power to the electrical and electronic circuits of the equipment.
L'équipement (1) comporte par ailleurs un détecteur The equipment (1) also comprises a detector
(5) comprenant un lecteur de bandelette de type connu. (5) comprising a strip reader of known type.
L'équipement (1) comprend également une interface d'entrée-sortie (6) connectée au microcalculateur (120) permettant la communication avec un équipement associé (20), par exemple une tablette ou un téléphone cellulaire. L'interface d'entrée-sortie (6) peut être de type filaire permettant la liaison avec l'équipement associé (20) par un cordon muni d'un connecteur adapté à l'équipement associé (20). Toutefois, de façon à éviter les problèmes de compatibilité des connectiques , l'interface d'entrée-sortie (6) est plutôt de type radiofréquence, par exemple de type Bluetooth . The equipment (1) also includes an input-output interface (6) connected to the microcomputer (120) for communication with associated equipment (20), for example a tablet or cell phone. The input-output interface (6) may be of wired type allowing the connection with the associated equipment (20) by a cord having a connector adapted to the associated equipment (20). However, in order to avoid connector compatibility problems, the input-output interface (6) is rather of the radio frequency type, for example of the Bluetooth type.
Dans le cas d'une communication Bluetooth, 1 '' établissement de la connexion commence par une phase d'inquisition (en anglais « inquiry »), pendant laquelle le programme d'ordinateur enregistré dans la mémoire (4) commande l'envoi d'une requête d'inquisition à tous les équipements présents dans la zone de portée, appelés points d'accès. Tous les périphériques recevant la requête répondent avec leur adresse.  In the case of a Bluetooth communication, the establishment of the connection begins with an inquisition phase, during which the computer program stored in the memory (4) commands the sending of an inquisition request to all devices present in the range, called access points. All devices receiving the request respond with their address.
L'équipement (1) choisit une adresse préalablement enregistrée ou sélectionnée par l'utilisateur et se synchronise avec le point d'accès selon une technique appelée paging, consistant à synchroniser son horloge et sa fréquence avec le point d'accès.  The equipment (1) selects an address previously registered or selected by the user and synchronizes with the access point according to a technique called paging, consisting of synchronizing its clock and its frequency with the access point.
Un lien s'établit ensuite avec le point d'accès, permettant à l'équipement (1) d'entamer une phase de découverte des services du point d'accès, selon un protocole appelé SDP (Service Discovery Protocol).  A link is then established with the access point, allowing the equipment (1) to begin a phase of discovery of the services of the access point, according to a protocol called SDP (Service Discovery Protocol).
A l'issue de cette phase de découverte de services, le périphérique maître est en mesure de créer un canal de communication avec le point d'accès en utilisant le protocole L2CAP.  At the end of this service discovery phase, the master device is able to create a communication channel with the access point using the L2CAP protocol.
Afin de protéger les données confidentielles, notamment les données historiques enregistrées dans la mémoire (4) lors d'acquisition antérieur, un canal supplémentaire RFCOMM, fonctionnant au-dessus du canal L2CAP est établi afin de fournir un port série virtuel.  In order to protect the confidential data, including the historical data stored in the memory (4) during prior acquisition, an additional RFCOMM channel, operating over the L2CAP channel is established to provide a virtual serial port.
De préférence, l'équipement associé (20) intègre un mécanisme de sécurité de pairage (en anglais pairing), permettant de restreindre 1 ' accès aux seuls utilisateurs autorisés afin de garantir un certain niveau d'étanchéité du picoréseau. Le pairage se fait à l'aide d'une clé de chiffrement communément appelée « code PIN » (Personal Information Number) . L'équipement associé (20) envoie ainsi une requête de pairage au périphérique maître. Ceci peut la plupart du temps déclencher une intervention de l'utilisateur pour saisir le code PIN du point d'accès. Si le code PIN reçu est correct, l'association a lieu. Preferably, the associated equipment (20) integrates a pairing security mechanism (in English pairing), allowing to restrict access only to authorized users in order to guarantee a certain level of tightness of the piconet. The pairing is done using an encryption key commonly called "PIN" (Personal Information Number). The associated equipment (20) sends a pairing request to the master device. This can most often trigger a user intervention to enter the access point PIN. If the received PIN is correct, the association takes place.
En mode sécurisé, le code PIN sera transmis chiffré à l'aide d'une seconde clé, afin d'éviter tout risque de compromission .  In secure mode, the PIN will be transmitted encrypted using a second key, to avoid any risk of compromise.
Lorsque le pairage est effectif, l'équipement associé (20) est libre d'utiliser le canal de communication ainsi établi afin de récupérer les données enregistrées dans la mémoire (4) de l'équipement (1), puis d'assurer une communication avec un serveur distant par un réseau de télécommunication numérique (par exemple 2 0 Internet) préférentiellement de manière sécurisée. Ce serveur distant enregistre les données fournies par l'équipement (1) en les associant à des données d'horodatage et/ou de géolocalisation provenant de l'équipement associé (20), afin de constituer une base de données historisées des données de l'utilisateur identifié par l'équipement (1) et effectuer des traitements pour fournir des données représentatives de l'évolution d'un indicateur de l'état physique de cet utilisateur.  When the pairing is effective, the associated equipment (20) is free to use the communication channel thus established in order to retrieve the data stored in the memory (4) of the equipment (1), and then to provide communication with a remote server via a digital telecommunication network (eg Internet) preferentially in a secure manner. This remote server records the data provided by the equipment (1) by associating them with time stamping and / or geolocation data coming from the associated equipment (20), in order to constitute a database of historical data of the equipment (1). user identified by the equipment (1) and perform processing to provide data representative of the evolution of an indicator of the physical state of this user.
Facultativement, après ledit traitement, le serveur renvoie le résultat de l'analyse à l'utilisateur via le même réseau ou un autre. Facultativement, le serveur enregistre les données et/ou le résultat de l'analyse sur un moyen d'enregistrement. Bien évidemment il peut être prévu des moyens de garantir 1 ' anonymat des caractéristiques physiologiques/cliniques du donneur et du receveur. L'équipement (1) permet l'enregistrement d'un identifiant d'un utilisateur, ou d'une pluralité d'identifiants correspondant chacun à un utilisateur donné. Optionally, after said processing, the server returns the result of the analysis to the user via the same network or another. Optionally, the server stores the data and / or the result of the analysis on a means of recording. Of course, there may be provided means to guarantee the anonymity of the physiological / clinical characteristics of the donor and the recipient. The equipment (1) allows the registration of an identifier of a user, or a plurality of identifiers each corresponding to a given user.
Cet identifiant est utilisé par l'équipement associé (20) pour établir la connexion avec le serveur et pour permettre le paramétrage des données personnelles de l'utilisateur, dans une application chargée dans la mémoire de l'équipement associé (20) et sur le serveur distant.  This identifier is used by the associated equipment (20) to establish the connection with the server and to allow the setting of the personal data of the user, in an application loaded into the memory of the associated equipment (20) and on the remote server.

Claims

Revendications claims
1 — Procédé de monitoring de l'évolution d'un indicateur d'état physique comprenant la masse graisseuse d'un sujet et/ou la masse musculaire d'un sujet, comprenant des étapes périodiques d'analyse d'un liquide biologique pour la quantification d'un biomarqueur représentatif d'une activité métabolique comprenant la lipolyse, la myolyse, la lipogénèse ou la myogénèse et de transmission du résultat de ladite analyse à un équipement connecté distant. 1 - Process for monitoring the evolution of a physical status indicator comprising the fat mass of a subject and / or the muscle mass of a subject, comprising periodic steps for analyzing a biological fluid for the quantifying a biomarker representative of a metabolic activity including lipolysis, myolysis, lipogenesis or myogenesis and transmitting the result of said analysis to a remote connected equipment.
2 — Procédé de monitoring selon la revendication 1 caractérisé en ce que ledit liquide biologique est choisi parmi le sang, l'urine, la sueur, la salive ou les larmes. 2 - Monitoring method according to claim 1 characterized in that said biological fluid is selected from blood, urine, sweat, saliva or tears.
3 — Procédé de monitoring selon la revendication 1 caractérisé en ce que ledit liquide biologique est l'urine. 3 - Monitoring method according to claim 1 characterized in that said biological fluid is urine.
4 — Procédé de monitoring selon la revendication 1 caractérisé en ce que ledit liquide biologique est le sang. 4 - Monitoring method according to claim 1 characterized in that said biological fluid is blood.
5 — Procédé de monitoring selon l'une quelconque des revendications 1 à 3 caractérisé en ce que le biomarqueur détecté dans les urines est choisi parmi le glycérol, la carnitine, 1 ' acylcarnitine , un corps cétonique, le béta aminoisobutyrate , un marqueur de l'inflammation et leurs métabolites . 5 - Monitoring method according to any one of claims 1 to 3 characterized in that the biomarker detected in the urine is selected from glycerol, carnitine, 1 acylcarnitine, a ketone body, beta aminoisobutyrate, a marker of l inflammation and their metabolites.
6 — Procédé de monitoring selon l'une quelconque des revendications 1 à 5 caractérisé en ce que le biomarqueur détecté dans le sang est choisi parmi les acides gras libres, le glycérol, la carnitine, 1 'acylcarnitine, un corps cétonique, le béta aminoisobutyrate, un marqueur de l'inflammation et leurs métabolites. 7 — Equipement pour la mise en œuvre du procédé selon l'une au moins des revendications précédentes caractérisé en ce qu'il comporte un moyen d'analyse d'un liquide biologique pour la quantification d'un biomarqueur, une horloge locale et un calculateur exécutant un programme informatique pour le pilotage dudit moyen d'analyse, le traitement des informations fournies par le moyen d'analyse, l'enregistrement dans une mémoire locale, et la communication avec un équipement connecté. 6 - Monitoring method according to any one of claims 1 to 5 characterized in that the biomarker detected in the blood is selected from free fatty acids, glycerol, carnitine, acylcarnitine, a ketone body, beta aminoisobutyrate , a marker of inflammation and their metabolites. 7 - Equipment for implementing the method according to at least one of the preceding claims, characterized in that it comprises means for analyzing a biological fluid for the quantification of a biomarker, a local clock and a calculator performing a computer program for controlling said analysis means, processing the information provided by the analyzing means, recording in a local memory, and communicating with a connected equipment.
8 — Système pour le monitoring d'un indicateur d'état physique comprenant la masse graisseuse d'un sujet et/ou la masse musculaire d'un sujet caractérisé en ce qu'il comprend au moins un équipement conforme à la revendication 7 et au moins un équipement connecté, notamment une tablette ou un téléphone cellulaire, ainsi qu'une application informatique commandant le fonctionnement dudit équipement connecté pour la communication avec ledit équipement, l'enregistrement local et/ou distant des résultats des analyses périodiques, la visualisation d'une information graphique calculée en fonction d'une pluralité d'analyse enregistrées. 8 - System for monitoring a physical status indicator comprising the fat mass of a subject and / or the muscular mass of a subject characterized in that it comprises at least one equipment according to claim 7 and less connected equipment, in particular a tablet or a cellular telephone, as well as a computer application controlling the operation of said connected equipment for communication with said equipment, the local and / or remote recording of the results of the periodic analyzes, the visualization of graphical information calculated according to a plurality of recorded analyzes.
9 — Produit programme d'ordinateur pour le pilotage d'un équipement connecté à un équipement conforme à la revendication 7 caractérisé en ce qu'il commande la communication entre l'équipement connecté et l'équipement d'analyse, l'enregistrement dans une mémoire de l'équipement connecté ou un serveur distant des données horodatées et le cas échéant géolocalisées et l'affichage sur un écran de l'équipement connecté d'une information graphique calculée en fonction d'une pluralité d'analyses enregistrées. 9 - Computer program product for controlling equipment connected to a device according to claim 7 characterized in that it controls the communication between the connected equipment and the analysis equipment, the recording in a memory of the connected equipment or a remote server of the time-stamped data and where appropriate geolocated and the display on a screen of the connected equipment of a graphical information computed according to a plurality of recorded analyzes.
EP15821152.4A 2014-12-19 2015-12-17 Method for monitoring the evolution of an indicator used to indicate the physical state of an individual, and monitoring device Withdrawn EP3232914A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1462862A FR3030757B1 (en) 2014-12-19 2014-12-19 METHOD FOR MONITORING THE EVOLUTION OF A PHYSICAL STATUS INDICATOR OF AN INDIVIDUAL AND MONITORING DEVICE
PCT/FR2015/053562 WO2016097615A1 (en) 2014-12-19 2015-12-17 Method for monitoring the evolution of an indicator used to indicate the physical state of an individual, and monitoring device

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US (1) US20170360367A1 (en)
EP (1) EP3232914A1 (en)
BR (1) BR112017013154A2 (en)
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WO (1) WO2016097615A1 (en)

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GB201611566D0 (en) * 2016-07-01 2016-08-17 Inside Biometrics Ltd Fitness method
FR3069323B1 (en) 2017-07-20 2023-10-20 Lsee ELECTROCHEMICAL STRIPS FOR MONITORING THE DEGRADATION OF FATS IN THE ORGANISM AND THEIR PREPARATION PROCESS

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CA2479801A1 (en) * 2002-03-26 2003-10-02 Piet Moerman A method and apparatus for quantifying caloric balance using metabolic parameters to assist subjects on weight management
EP2280640A4 (en) 2008-04-21 2013-10-09 Carl Frederick Edman Metabolic energy monitoring system

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US20170360367A1 (en) 2017-12-21
BR112017013154A2 (en) 2018-04-10
FR3030757B1 (en) 2018-04-06
WO2016097615A1 (en) 2016-06-23

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