EP3232914A1 - Verfahren zur überwachung der entwicklung eines indikators zur anzeige des physischen zustands eines individuums und überwachungsvorrichtung - Google Patents
Verfahren zur überwachung der entwicklung eines indikators zur anzeige des physischen zustands eines individuums und überwachungsvorrichtungInfo
- Publication number
- EP3232914A1 EP3232914A1 EP15821152.4A EP15821152A EP3232914A1 EP 3232914 A1 EP3232914 A1 EP 3232914A1 EP 15821152 A EP15821152 A EP 15821152A EP 3232914 A1 EP3232914 A1 EP 3232914A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- equipment
- monitoring
- biological fluid
- subject
- biomarker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4869—Determining body composition
- A61B5/4872—Body fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
- A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Definitions
- the present invention is in the field of methods for monitoring the metabolism of a subject and associated connected devices.
- the invention is also part of the devices for controlling his diet.
- Obesity has become a major public health problem. It is defined by an abnormal or excessive accumulation of body fat which represents a risk to health and deteriorates the quality of life. Obesity is a major risk factor for diabetes, cardiovascular disease or cancer. In 2014, 1.4 billion adults were overweight, resulting in 3.4 million deaths worldwide each year. Formerly reserved for rich countries, it also progresses drastically in emerging countries.
- Obesity is mainly due to an imbalance between an excess food intake and insufficient energy expenditure.
- Food is a fundamental vector of the health status of individuals. However, its importance in medical practices is underestimated or even misunderstood. Multiple solutions have been developed to combat obesity such as diets, coaching, sports, diet pills, surgery, appetite suppressants ... But often, their use results in failures due to their maladjustment. to the individual in particular.
- the present invention proposes to allow the greatest number to be able to follow his metabolism in order to guide his choice of diet and physical activity according to the goal he has set.
- US2003 / 0223905 patent application relates to a weight loss system and a method measuring one or more metabolic parameters in a body fluid sample and correlating the level of the metabolic parameter to a change in body fat level and a metabolic stage. .
- This system makes it possible to qualify the energy balance of the subject, the energy balance being understood as the amount of energy ingested compared to the amount of energy expended by tracing a marker of lipolysis as a ketone body, glycerol or a fatty acid free.
- WO2009 / 131664 a metabolic energy monitoring system comprising physiological parameter measurement platforms for calculating an energy equilibrium on the basis of the caloric intake and the energy spent. This device is preferably permanently worn on the body for continuous measurement.
- Metabolic activity is a combination of different parameters, the monitoring of which can not be limited to monitoring the body fat mass and its evolution.
- the devices of the prior art focus on the quantification of energy in the form of calories spent and ingested in order to formulate recommendations to the user, this quantification relying on algorithms that do not take into account metabolic specificities. specific to the individual.
- the present invention proposes, according to its most general acceptance, a method of monitoring the evolution of a physical status indicator comprising the fat mass of a subject and / or the muscle mass of a patient. subject, including periodic steps method of analyzing a biological fluid for quantifying a biomarker representative of a metabolic activity including lipolysis, myolysis, lipogenesis or myogenesis and transmitting the result of said analysis to a remote connected equipment.
- the present invention allows a metabolism monitoring of a subject over a period of time given a frequency at the free choice of the user.
- the user can first use the invention to understand his metabolism and correlate his eating habits, behavioral and physical activity to a measured degree of metabolism, for example lipolysis or myolysis.
- the user can capitalize the data in order to establish a repository allowing him to be his own witness and thus to be able to adapt his diet or practice the appropriate physical activity according to the chosen target.
- the present invention therefore has the advantage that the control values are directly related to the individual by the constitution of this frame of reference and not to standards or methods of calculating the energy spent according to generally accepted methods.
- the method according to the invention comprises:
- the method may further comprise an identification step among this individual reference of the physical activity, the food habit and / or behavior most appropriate to the objective that the subject has set.
- This objective can be a muscular mass to achieve, a body weight to reach, a fat mass to be reduced, a metabolic activity to maintain ...
- the invention is part of personalized medicine, placing food at the center of the health and well-being of the individual and by easily studying objectively measurable, quantifiable and correlable parameters to the intensity of the metabolism, particularly lipolysis. , myolysis and their counterparts lipogenesis and myogenesis.
- the biomarker is understood as circulating molecules and / or found in a biological fluid selected from blood, urine, sweat, saliva or tears.
- a biological fluid selected from blood, urine, sweat, saliva or tears.
- the biological fluid is urine or blood according to embodiments.
- biomarkers can be byproducts of muscle breakdown and / or body fat.
- concentration of these biomarkers varies according to the metabolism of the subject, reflecting the lipid metabolism (lipolysis / lipogenesis) or the muscular metabolism (myolysis / myogenesis).
- the biomarker detected in the urine is chosen from glycerol, carnitine, acylcarnitine, a ketone body, beta aminoisobutyrate, a marker of inflammation and their metabolites.
- the biomarker detected in the blood is chosen from free fatty acids, glycerol, carnitine, acylcarnitine, a ketone body, beta aminoisobutyrate, a marker of inflammation and their metabolites.
- the marker of the inflammation detected in the biological fluid is an interleukin, preferentially interleukin 6.
- the invention also relates to equipment for implementing the method according to the invention.
- the equipment comprises a means for analyzing a biological fluid for the quantification of a biomarker, a local clock and a computer executing a computer program for controlling said analysis means, the processing of the information provided by the means of analysis. analysis, recording in local memory, and communication with connected equipment.
- the means for analyzing a biological fluid comprise means for receiving the biological liquid such as a reservoir or an absorbent material. These reception means can be coupled to biosensors to quantify the biomarker, such as antibodies or enzymes.
- These receiving means, coupled or not with biosensors may be disposable or cleanable. Preferably they are for single use.
- the equipment comprises data communication means with a remote connected equipment, preferably wireless communication means such as bluetooth, wifi, internet or infrared.
- a remote connected equipment preferably wireless communication means such as bluetooth, wifi, internet or infrared.
- the invention relates to a system for monitoring a physical status indicator comprising the fat mass of a subject and / or the muscle mass of a subject, the system comprising at least one equipment such as defined above and at least one connected equipment, in particular a tablet or a cellular telephone, as well as a computer application controlling the operation of said connected equipment for communication with said equipment, the local and / or remote recording of the results of the periodic analyzes, viewing a graphical information calculated according to a plurality of recorded analyzes.
- the invention relates to a computer program for controlling equipment connected to equipment as defined above, the computer program controlling the communication between the connected equipment and the analysis equipment. , recording in a memory of the connected equipment or a remote server time-stamped data and where appropriate geolocated and the display on a screen of the connected equipment of a graphical information calculated according to a plurality of saved analyzes.
- the device according to the invention makes it possible to measure one or more biomarkers, in the blood or in the urine.
- the device can measure in the blood either glycerol or beta-aminoisobutyrate or interleukin 6 or a combination thereof.
- the device makes it possible to measure the concentration of glycerol in the blood.
- the user measures a glycerol concentration of 0.3 mmol / L at rest and a concentration of 1 mmol / L after one hour of cycling at a moderate pace.
- These physical activities can for example be walking, running, swimming or any other physical activity.
- the user thus creates an individual repository.
- the user measures a concentration of beta- aminoisobutyrate of 1.8 ⁇ mol / L and a beta-aminoisobutyrate concentration of 2.7 ⁇ mol / L after one hour of moderate speed cycling.
- the user thus creates an individual repository. It compares the values obtained after different physical activities and identifies the most adapted to its metabolism to stimulate the degradation of its fat mass and / or to stimulate the synthesis of its muscular mass.
- the user measures a concentration of interleukin 6 at 10 ng / L at rest and an interleukin 6 concentration of 120 ng / L after one hour of moderate speed cycling.
- Biomarker measurement data are recorded.
- the raw parameters measured are used to establish a scale of intensity representative of the metabolic activity (lipolysis, myolysis ).
- An arbitrary unit is assigned and a color scale representing intensity (ranging from red for very low lipolysis, to green for high intensity) is generated.
- the equipment includes an electronic biosensor for quantifying the biomarker of interest in the biological fluid.
- the user places a sample of a biological fluid on a strip of polymers on which biosensors are attached. Then the user disposes the strip in the biodetector.
- the biodetector measures the biomarker concentration in the biological sample and records it. The user can then choose to send the measurement on a computer type equipment, mobile phone, tablet by bluetooth.
- the strip is disposable after use. It has the appropriate biosensors according to the biomarker to be quantified.
- the measurement received for example by the user's phone is integrated into an application that will process it. The user can then visualize his physical state at the time of measurement. After an effort, the user performs the same manipulation again and compares the results.
- the user builds his own database in order to correlate his physical condition with the food he has consumed and his physical activity.
- This database constitutes its individual reference system.
- the user thanks to the invention, knows the impact on his metabolism of a particular food habit or of such or such intensity of physical activity. It therefore has a visibility on the practices to implement to achieve its objective, for example a given weight or a given muscle mass.
- the user can also follow the evolution of his progress to reach the goal he has set.
- the user can also combine in this application other parameters from other devices connected such as a connected scale to follow the evolution curve of its weight, and also its body fat.
- the application also offers recommendations based on the user's repository according to the objective he has set.
- the user can follow in real time the evolution of his physical state according to the goal he has set and especially adapt the diet and physical intensity according to this goal to achieve.
- the invention therefore makes it possible to strongly motivate the user since the latter visualizes concretely and in real time his progress with respect to the objective.
- FIG. 1 shows the block diagram of an equipment (1) according to a particular embodiment of the present invention. It includes a microcomputer (2) capable of executing computer instructions and data processing.
- This microcomputer (2) comprises a microprocessor (3) which can be of any type known from the state of the art.
- the microcomputer (2) also comprises a storage unit (4) capable of receiving a computer program defining a set of instructions specific to the implementation of the method, and storing data.
- a battery (7) provides power to the electrical and electronic circuits of the equipment.
- the equipment (1) also comprises a detector
- the equipment (1) also includes an input-output interface (6) connected to the microcomputer (120) for communication with associated equipment (20), for example a tablet or cell phone.
- the input-output interface (6) may be of wired type allowing the connection with the associated equipment (20) by a cord having a connector adapted to the associated equipment (20).
- the input-output interface (6) is rather of the radio frequency type, for example of the Bluetooth type.
- the establishment of the connection begins with an inquisition phase, during which the computer program stored in the memory (4) commands the sending of an inquisition request to all devices present in the range, called access points. All devices receiving the request respond with their address.
- the equipment (1) selects an address previously registered or selected by the user and synchronizes with the access point according to a technique called paging, consisting of synchronizing its clock and its frequency with the access point.
- paging consisting of synchronizing its clock and its frequency with the access point.
- a link is then established with the access point, allowing the equipment (1) to begin a phase of discovery of the services of the access point, according to a protocol called SDP (Service Discovery Protocol).
- SDP Service Discovery Protocol
- the master device is able to create a communication channel with the access point using the L2CAP protocol.
- an additional RFCOMM channel operating over the L2CAP channel is established to provide a virtual serial port.
- the associated equipment (20) integrates a pairing security mechanism (in English pairing), allowing to restrict access only to authorized users in order to guarantee a certain level of tightness of the piconet.
- the pairing is done using an encryption key commonly called "PIN" (Personal Information Number).
- PIN Personal Information Number
- the associated equipment (20) sends a pairing request to the master device. This can most often trigger a user intervention to enter the access point PIN. If the received PIN is correct, the association takes place.
- the PIN will be transmitted encrypted using a second key, to avoid any risk of compromise.
- the associated equipment (20) is free to use the communication channel thus established in order to retrieve the data stored in the memory (4) of the equipment (1), and then to provide communication with a remote server via a digital telecommunication network (eg Internet) preferentially in a secure manner.
- a remote server records the data provided by the equipment (1) by associating them with time stamping and / or geolocation data coming from the associated equipment (20), in order to constitute a database of historical data of the equipment (1).
- user identified by the equipment (1) and perform processing to provide data representative of the evolution of an indicator of the physical state of this user.
- the server returns the result of the analysis to the user via the same network or another.
- the server stores the data and / or the result of the analysis on a means of recording.
- the equipment (1) allows the registration of an identifier of a user, or a plurality of identifiers each corresponding to a given user.
- This identifier is used by the associated equipment (20) to establish the connection with the server and to allow the setting of the personal data of the user, in an application loaded into the memory of the associated equipment (20) and on the remote server.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Business, Economics & Management (AREA)
- General Business, Economics & Management (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Ecology (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1462862A FR3030757B1 (fr) | 2014-12-19 | 2014-12-19 | Procede de monitoring de l'evolution d'un indicateur d'etat physique d'un individu et dispositif de monitoring |
PCT/FR2015/053562 WO2016097615A1 (fr) | 2014-12-19 | 2015-12-17 | Procédé de monitoring de l'évolution d'un indicateur d'état physique d'un individu et dispositif de monitoring |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3232914A1 true EP3232914A1 (de) | 2017-10-25 |
Family
ID=52824360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15821152.4A Withdrawn EP3232914A1 (de) | 2014-12-19 | 2015-12-17 | Verfahren zur überwachung der entwicklung eines indikators zur anzeige des physischen zustands eines individuums und überwachungsvorrichtung |
Country Status (5)
Country | Link |
---|---|
US (1) | US20170360367A1 (de) |
EP (1) | EP3232914A1 (de) |
BR (1) | BR112017013154A2 (de) |
FR (1) | FR3030757B1 (de) |
WO (1) | WO2016097615A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201611566D0 (en) * | 2016-07-01 | 2016-08-17 | Inside Biometrics Ltd | Fitness method |
FR3069323B1 (fr) | 2017-07-20 | 2023-10-20 | Lsee | Bandelettes electrochimiques permettant le suivi de la degradation des graisses de l'organisme et leur procede de preparation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003219427A1 (en) * | 2002-03-26 | 2003-10-08 | Inverness Medical Switzerland Gmbh | A method and apparatus for quantifying caloric balance using metabolic parameters to assist subjects on weight management |
US8690769B2 (en) | 2008-04-21 | 2014-04-08 | Philometron, Inc. | Metabolic energy monitoring system |
-
2014
- 2014-12-19 FR FR1462862A patent/FR3030757B1/fr active Active
-
2015
- 2015-12-17 EP EP15821152.4A patent/EP3232914A1/de not_active Withdrawn
- 2015-12-17 US US15/534,238 patent/US20170360367A1/en not_active Abandoned
- 2015-12-17 BR BR112017013154-4A patent/BR112017013154A2/pt not_active Application Discontinuation
- 2015-12-17 WO PCT/FR2015/053562 patent/WO2016097615A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
FR3030757A1 (fr) | 2016-06-24 |
BR112017013154A2 (pt) | 2018-04-10 |
US20170360367A1 (en) | 2017-12-21 |
WO2016097615A1 (fr) | 2016-06-23 |
FR3030757B1 (fr) | 2018-04-06 |
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