EP3226966B1 - System zur steigerung des erholungswertes einer schlafpause - Google Patents

System zur steigerung des erholungswertes einer schlafpause Download PDF

Info

Publication number
EP3226966B1
EP3226966B1 EP15804605.2A EP15804605A EP3226966B1 EP 3226966 B1 EP3226966 B1 EP 3226966B1 EP 15804605 A EP15804605 A EP 15804605A EP 3226966 B1 EP3226966 B1 EP 3226966B1
Authority
EP
European Patent Office
Prior art keywords
sleep
subject
stage
sleep stage
brain activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP15804605.2A
Other languages
English (en)
French (fr)
Other versions
EP3226966A1 (de
Inventor
Gary Nelson Garcia Molina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of EP3226966A1 publication Critical patent/EP3226966A1/de
Application granted granted Critical
Publication of EP3226966B1 publication Critical patent/EP3226966B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1103—Detecting eye twinkling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/372—Analysis of electroencephalograms
    • A61B5/374—Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/38—Acoustic or auditory stimuli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4812—Detecting sleep stages or cycles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36078—Inducing or controlling sleep or relaxation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0016—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the smell sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0022—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the tactile sense, e.g. vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0055—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with electric or electro-magnetic fields
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0083—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus especially for waking up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/08—Other bio-electrical signals
    • A61M2230/10—Electroencephalographic signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/18—Rapid eye-movements [REM]

Definitions

  • the present disclosure pertains to a system for increasing the restorative value of a nap.
  • WO 2014/170881 A1 discloses a system for managing a sleep session of a subject.
  • WO 2005/084538 A1 discloses a system for waking a user in a desired sleep state.
  • one or more aspects of the present disclosure relate to a system configured to manage a sleep session of a subject.
  • the system comprises one or more sensory stimulators, one or more sensors, one or more physical computer processors and/or other components.
  • the one or more sensory stimulators are configured to provide sensory stimuli to the subject during the sleep session.
  • the one or more sensors are configured to generate output signals conveying information related to brain activity of the subject.
  • the word "unitary” means a component is created as a single piece or unit. That is, a component that includes pieces that are created separately and then coupled together as a unit is not a “unitary” component or body.
  • the statement that two or more parts or components "engage” one another shall mean that the parts exert a force against one another either directly or through one or more intermediate parts or components.
  • the term “number” shall mean one or an integer greater than one (i.e., a plurality).
  • FIG. 1 is a schematic illustration of a system 10 configured to manage a sleep session of a subject 12.
  • system 10 includes one or more of a sensory stimulator 16, a sensor 18, a physical computer processor 20, electronic storage 22, a user interface 24, and/or other components.
  • the sleep session is a nap and system 10 is configured to increase the restorative value of the nap by enhancing and/or maintaining sleep slow waves in subject 12 during the nap with sensory stimuli.
  • Sleep need dissipates by sleeping.
  • the manner in which sleep need dissipation occurs is linked to the temporal dynamics of SWA.
  • SWA has a typical behavior throughout the cyclic variations of a sleep session. SWA builds up during non-rapid eye movement (NREM) sleep, declines before the onset of rapid-eye-movement (REM) sleep, and remains low during REM sleep. The level of SWA for successive NREM cycles gets progressively lower. This is illustrated in FIG. 3 .
  • S(t) is the sleep need
  • SWA(t) is the slow-wave activity at time t
  • S 0 is the sleep need at the beginning of the sleep session.
  • the summation of the SWA from sleep onset up to a time t is referred to as cumulative SWA or CUMSWA (t).
  • the decrease in sleep need (S 0 - S(t)) after a sleep duration of "t" units of time, is directly proportional to CUMSWA(t).
  • CUMSWA(t) provides an indication of the restorative value of sleep.
  • sensory stimulator 16 is configured to provide sensory stimuli to subject 12.
  • Sensory stimulator 16 is configured to provide sensory stimulation to subject 12 prior to a sleep session, during a sleep session, and/or at other times.
  • sensory stimulator 16 may be configured to provide sensory stimuli to subject 12 to induce deeper sleep in subject 12, maintain sleep in a specific sleep stage (e.g., NREM stage N2 sleep as described below) during the sleep session, during deep (e.g., slow wave sleep) sleep in a sleep session, to facilitate a transition to a lighter stage of sleep, and/or for other reasons and/or at other times.
  • sensory stimulator 16 may be configured to induce, increase, enhance, maintain, and/or decrease sleep slow waves in subject 12.
  • Sensor 18 is configured to generate output signals conveying information related to brain activity of subject 12.
  • the brain activity of subject 12 may correspond to a current sleep stage of subject 12.
  • the current sleep stage of subject 12 may be associated with rapid eye movement (REM) sleep, non-rapid eye movement (NREM) sleep, and/or other sleep.
  • the current sleep stage of subject 12 may be one or more of NREM stage N1, stage N2, or stage N3 sleep, REM sleep, and/or other sleep stages.
  • Sensor 18 may comprise one or more sensors that measure such parameters directly.
  • sensor 18 may include electroencephalogram (EEG) electrodes configured to detect electrical activity along the scalp of subject 12 resulting from current flows within the brain of subject 12.
  • Sensor 18 may comprise one or more sensors that generate output signals conveying information related to brain activity of subject 12 indirectly.
  • EEG electroencephalogram
  • one or more sensors 18 may generate an output based on a heart rate of subject 12 (e.g., sensor 18 may be a heart rate sensor located on the chest of subject 12, and/or be configured as a bracelet on a wrist of subject 12, and/or be located on another limb of subject 12), movement of subject 12 (e.g., sensor 18 may include a bracelet around the wrist and/or ankle of subject 12 with an accelerometer such that sleep may be analyzed using actigraphy signals), respiration of subject 12, and/or other characteristics of subject 12.
  • sensor 18 is illustrated at a single location near subject 12, this is not intended to be limiting.
  • Sensor 18 may include sensors disposed in a plurality of locations, such as for example, within (or in communication with) sensory stimulator 16, coupled (in a removable manner) with clothing of subject 12, worn by subject 12 (e.g., as a headband, wristband, etc.), positioned to point at subject 12 while subject 12 sleeps (e.g., a camera that conveys output signals related to movement of subject 12), and/or in other locations.
  • sensors disposed in a plurality of locations, such as for example, within (or in communication with) sensory stimulator 16, coupled (in a removable manner) with clothing of subject 12, worn by subject 12 (e.g., as a headband, wristband, etc.), positioned to point at subject 12 while subject 12 sleeps (e.g., a camera that conveys output signals related to movement of subject 12), and/or in other locations.
  • Processor 20 is configured to provide information processing capabilities in system 10.
  • processor 20 may comprise one or more of a digital processor, an analog processor, a digital circuit designed to process information, an analog circuit designed to process information, a state machine, and/or other mechanisms for electronically processing information.
  • processor 20 is shown in FIG. 1 as a single entity, this is for illustrative purposes only.
  • processor 20 may comprise a plurality of processing units. These processing units may be physically located within the same device (e.g., sensory stimulator 16), or processor 20 may represent processing functionality of a plurality of devices operating in coordination.
  • processor 20 is configured to execute one or more computer program components.
  • the one or more computer program components may comprise one or more of a brain activity component 30, a sleep stage component 32, a control component 34, and/or other components.
  • Processor 20 may be configured to execute components 30, 32, and/or 34 by software; hardware; firmware; some combination of software, hardware, and/or firmware; and/or other mechanisms for configuring processing capabilities on processor 20.
  • components 30, 32, and 34 are illustrated in FIG. 1 as being co-located within a single processing unit, in embodiments in which processor 20 comprises multiple processing units, one or more of components 30, 32, and/or 34 may be located remotely from the other components.
  • the description of the functionality provided by the different components 30, 32, and/or 34 described below is for illustrative purposes, and is not intended to be limiting, as any of components 30, 32, and/or 34 may provide more or less functionality than is described.
  • processor 20 may be configured to execute one or more additional components that may perform some or all of the functionality attributed below to one of components 30, 32, and/or 34.
  • Brain activity component 30 is configured to determine one or more brain activity parameters of subject 12. Brain activity component 30 is configured to determine one or more brain activity parameters based on the output signals from sensor 18 and/or other information. In some embodiments, determining one or more brain activity parameters may include generating and/or monitoring an electroencephalogram (EEG) and/or an electrooculogram (EOG) for a sleep session of subject 12. The EEG and/or EOG may be displayed, for example, by user interface 24.
  • EEG electroencephalogram
  • EOG electrooculogram
  • brain activity component 30 is configured such that the one or more brain activity parameters are and/or are related to a frequency, amplitude, phase, presence of specific sleep patterns such as spindles, K-complexes, sleep slow waves, alpha waves, and/or other characteristics of an EEG and/or EOG signal.
  • the one or more brain activity parameters are determined based on the frequency, amplitude, and/or other characteristics of the EEG and/or EOG signal.
  • the determined brain activity parameters and/or the characteristics of the EEG and/or EOG may be and/or indicate sleep states that correspond to the REM and/or NREM sleep stages described herein.
  • typical EEG characteristics during NREM sleep include a transition from alpha waves (e.g., about 8-12 Hz) to theta waves (e.g., about 4-7 Hz) for sleep stage N1; presence of sleep spindles (e.g., about 11 to 16 Hz) and/or K-complexes (e.g., similar to sleep slow waves) for sleep stage N2; presence of delta waves (e.g., about 0.5 to 2 Hz), also known as sleep slow waves, with peak-to-peak amplitudes greater than about 75uVfor sleep stage N3; and/or other characteristics.
  • alpha waves e.g., about 8-12 Hz
  • theta waves e.g., about 4-7 Hz
  • K-complexes e.g., similar to sleep slow waves
  • delta waves e.g., about 0.5 to 2 Hz
  • brain activity component 30 is configured such that determining the brain activity parameters includes determining one or more macro-parameters.
  • the one or more macro-parameters include one or more of a ratio between power in a beta band (about 15-30Hz) of the EEG signal and power in a delta band (about 0.5-4Hz) of the EEG signal, a ratio between power in an alpha band (about 8-12Hz) of the EEG signal and power in a theta band (about 4-7Hz) of the EEG signal, a ratio between power in a sigma band (about 11-15Hz) of the EEG signal and the power in the delta band (about 0.5-4Hz) of the EEG signal, and/or other macro parameters.
  • the one or more macro-parameters may include any ratio between a power in a "fast” (e.g., about 10-50Hz) frequency band (e.g., beta, sigma, alpha, gamma) of the EEG signal (and/or subband where one or both limits are in the 10 to 50Hz interval such as high alpha 10-12Hz, beta 15-30Hz, sigma 11-16Hz, gamma 30-50Hz) and power in a "slow” frequency band (e.g., delta, theta) of the EEG signal that can characterize sleep depth during NREM sleep.
  • a "fast” frequency band e.g., about 10-50Hz
  • Sleep stage component 32 is configured to determine sleep stages in subject 12. The sleep stages are determined based on the output signals, the brain activity parameters, and/or other information. In some embodiments, the sleep stages are determined based on the one or more macro-parameters and the one or more micro-events. In some embodiments, determining the sleep stage is and/or includes detecting sleep stages based on the output signals, the brain activity parameters, the macro-parameters, the micro-events, and/or other information. As described above, the sleep stages of subject 12 may include and/or correspond to one or more of wakefulness, REM sleep, stage N1, stage N2, and/or stage N3 sleep. In some embodiments, slow wave sleep and/or slow wave activity may correspond to stage N3 sleep.
  • stage N2 and/or stage N3 sleep may be slow wave sleep and/or correspond to slow wave activity.
  • sleep stage component 32 may determine the sleep stage of subject 12 based on an analysis of the information conveyed by the output signals of sensor 18, the parameters determined by brain activity component 30, and/or other information. The analysis may include monitoring an EEG and/or an EOG for the sleep session of subject 12.
  • sleep stage component 32 makes such predictions in an ongoing manner for a sleep session, at regular time intervals during the sleep session, at intervals programmed at manufacture, and/or at other times.
  • thresholds on the log beta/delta ratio used to detect N1 to N2, N2 to N3, and/or other sleep stage transitions may be determined using information from previous sleep sessions of subject 12, demographic information for a population of subjects similar to subject 12, calibration sleep sessions, and/or other information.
  • sleep stage component 32 is configured to determine one or more arousal levels of subject 12 for the sleep session.
  • the one or more arousal levels may indicate a level of wakefulness in subject 12.
  • the one or more arousal levels may be determined based on the output signals of sensors 18, parameters determined by brain activity component 30, information stored in electronic storage 22, testing performed prior to the sleep session, information received and/or selected via user interface 24, and/or other information.
  • the one or more arousal levels may be determined based on the analysis of the information related to the EEG and/or EOG. For example, the likelihood for an arousal may be quantified from the EEG power in the beta band in short temporal windows (typically about 1.5 second long, for example).
  • control component 34 controls sensory stimulator 16 to deliver sensory stimulation to subject 12 to maintain stage N2 sleep in subject 12 during the sleep session, and/or facilitate transitions between sleep states and/or stages (e.g., when subject 12 is falling asleep and/or when it is time to wake subject 12).
  • the timing, frequency, intensity, and/or other parameter determinations are determined based on previous sleep sessions of subject 12, sleep sessions of a representative group of subjects related to subject 12, may be determined at manufacture, and/or determined by other methods.
  • control component 34 is configured to control sensory stimulator 16 such that the timing of the sensory stimuli (e.g., auditory tones) comprises a regular, repeating interval of time between individual stimuli delivered to subject 12 and/or may has an irregular interval.
  • control component 34 controls sensory stimulator 16 to provide the sensory stimulation during the sleep session such that the sensory stimulation does not unintentionally wake subject 12 and/or cause subject to transition into deep (stage N3) sleep.
  • Controlling sensory stimulator 16 to provide sensory stimulation so subject 12 is not unintentionally aroused from sleep and/or allowed to transition to deep sleep may be accomplished by controlling the timing, frequency, intensity, and/or other parameters of the stimulation.
  • control component 34 may control sensory stimulator 16 to provide the sensory stimulation at a low intensity level when subject 12 is to remain asleep and at a high intensity level if subject 12 is to be aroused from deep sleep.
  • control component 34 may cause sensory stimulator 16 to deliver acoustic stimulation to subject 12 to increase sleep slow waves just after subject 12 has fallen asleep (e.g., to speed to the transition to stage N2 sleep), and not while subject 12 is falling asleep.
  • sensory stimulator 16 is controlled to cease providing sensory stimulation to subject 12 responsive to a prediction of a transition from the second sleep stage to the third sleep stage indicating that subject 12 is about to enter the third sleep stage.
  • sensory stimulator 16 is controlled to deliver sensory stimulation to wake subject 12 responsive to the brain activity parameters and/or other information indicating that subject 12 has entered the third sleep stage.
  • control component 34 controls a sensory stimulator 16 such that any ongoing stimulation stops and/or an onset of stimulation is delayed.
  • a transition to sleep stage N3 would be detected responsive to a breach of threshold 444.
  • sensory stimulation 402 is delivered once the transition to the deeper portion of sleep stage N2 is detected (e.g., responsive to breaching threshold 442) and ceased 408 because a transition into N3 is predicted.
  • control component 34 controls a sensory stimulator 16 such that any ongoing stimulation stops 526 and/or an onset of stimulation is delayed 528. If no arousal is detected, macro-parameters 530, micro-events 532 (determined by brain activity component 30 shown in FIG. 1 ) and/or other parameters are used to determine 540 the sleep stage (e.g., REM, NREM stage N1, the lighter part of N2, the deeper part of N2, N3) of subject 12. If deep sleep (N3) is detected, the auditory stimulation is delivered 542 to wake subject 12.
  • the sleep stage e.g., REM, NREM stage N1, the lighter part of N2, the deeper part of N2, N3
  • method 700 may be implemented in one or more processing devices (e.g., a digital processor, an analog processor, a digital circuit designed to process information, an analog circuit designed to process information, a state machine, and/or other mechanisms for electronically processing information).
  • the one or more processing devices may include one or more devices executing some or all of the operations of method 700 in response to instructions stored electronically on an electronic storage medium.
  • the one or more processing devices may include one or more devices configured through hardware, firmware, and/or software to be specifically designed for execution of one or more of the operations of method 700.
  • the one or more micro-events include one or more of an eye blink, slow eye movements, a spindle, a slow-wave, and/or other micro events.
  • operation 704 is performed by a processor component the same as or similar to brain activity component 30 (shown in FIG. 1 and described herein).
  • sleep stages of the subject are determined.
  • the sleep stages are determined based on the brain activity parameters.
  • the sleep stages include a first sleep stage, a second sleep stage that is deeper than the first sleep stage, and a third sleep stage that is deeper than the first sleep stage and the second sleep stage.
  • the first sleep stage includes one or more of REM sleep, NREM stage N1 sleep, or a lighter portion of NREM stage N2 sleep.
  • the second sleep stage includes a deeper portion of NREM stage N2 sleep.
  • the third sleep stage includes NREM stage N3 sleep.
  • the sleep stages are determined based on the one or more macro-parameters and the one or more micro-events.
  • operation 706 is performed by a processor component the same as or similar to sleep stage component 32 (shown in FIG. 1 and described herein).
  • User interface 24 is configured to provide an interface between system 10 and subject 12, and/or other users through which subject 12 and/or other users may provide information to and receive information from system 10 (e.g., a target sleep stage). This enables data, cues, results, and/or instructions and any other communicable items, collectively referred to as "information," to be communicated between a user (e.g., subject 12) and one or more of sensory stimulator 16, sensor 18, processor 20, and/or other components of system 10. For example, an EEG may be displayed to a caregiver via user interface 24.

Claims (3)

  1. System (10), das zur Verwaltung einer Schlaf-'Session' einer Person konfiguriert ist, wobei das System umfasst:
    einen oder mehrere sensorische Stimulatoren (16), die so konfiguriert sind, dass sie der Person sensorische Stimulationen während der Schlaf-'Session' zuführen;
    einen oder mehrere Sensoren (18), die so konfiguriert sind, dass sie Ausgangssignale zur Übertragung von Informationen erzeugen, die auf die Gehirnaktivität der Person bezogen sind; sowie
    einen oder mehrere physische Computerprozessoren (20), die durch computerlesbare Instruktionen konfiguriert sind, um:
    Gehirnaktivitätsparameter der Person aufgrund der Ausgangssignale zu ermitteln, wobei die Gehirnaktivitätsparameter für Schlafstadien der Person bezeichnend sind;
    die Schlafstadien der Person aufgrund der Gehirnaktivitätsparameter zu ermitteln, wobei die Schlafstadien ein erstes Schlafstadium, ein zweites Schlafstadium, das tiefer als das erste Schlafstadium ist, sowie ein drittes Schlafstadium, das tiefer als das erste Schlafstadium und das zweite Schlafstadium ist, umfassen;
    Übergänge von dem zweiten Schlafstadium in das dritte Schlafstadium aufgrund der Gehirnaktivitätsparameter vorauszusagen; und
    den einen oder mehrere sensorische Stimulatoren zu steuern, um:
    der Person eine sensorische Stimulation in Reaktion auf den Übergang von dem ersten Schlafstadium in das zweite Schlafstadium zuzuführen; und
    das Zuführen sensorischer Stimulation zu der Person in Reaktion auf eine Voraussage eines Übergangs von dem zweiten Schlafstadium in das dritte Schlafstadium, die signalisiert, dass die Person gerade dabei ist, in das dritte Schlafstadium überzugehen, zu beenden, wobei der eine oder mehrere physische Computerparameter so konfiguriert sind, dass:
    das erste Schlafstadium einen oder mehrere der Folgenden umfasst: REM-Schlaf, NREM-Phase N1-Schlaf oder einen leichteren Teil von NREM-Phase N2-Schlaf umfasst;
    das zweite Schlafstadium einen tieferen Teil von NREM-Phase N2-Schlaf umfasst; und
    das dritte Schlafstadium NREM-Phase N3-Schlaf umfasst.
  2. System nach Anspruch 1, wobei der eine oder mehrere Sensoren so konfiguriert sind, dass die Ausgangssignale ein EEG-Signal enthalten,
    wobei der eine oder mehrere physische Computerprozessoren so konfiguriert sind, dass das Ermitteln der Gehirnaktivitätsparameter beinhaltet:
    Ermitteln von einem oder mehreren Makroparametern, wobei der eine oder mehrere Makroparameter ein oder mehrere der Folgenden umfasst: ein Verhältnis zwischen Leistung in einem Beta-Band des EEG-Signals und Leistung in einem Delta-Band des EEG-Signals, ein Verhältnis zwischen Leistung in einem Alpha-Band des EEG-Signals und Leistung in einem Theta-Band des EEG-Signals, ein Verhältnis zwischen Leistung in einem Sigma-Band des EEG-Signals und der Leistung in dem Delta-Band des EEG-Signals, oder ein Verhältnis zwischen Leistung in einem Fast-Frequency-Band des EEG-Signals und Leistung in einem Slow-Frequency-Band des EEF-Signals; sowie
    Ermitteln von einem oder mehreren Mikroereignissen, wobei das eine oder mehrere Mikroereignisse einen oder mehrere eines Lidschlags, langsamen Augenbewegungen, einer Spindel oder einer Slow-Wave umfassen; und
    wobei der eine oder mehrere physische Computerprozessoren so konfiguriert sind, dass Schlafstadien aufgrund des einen oder mehrerer Makroparameter und des einen oder mehrerer Mikroereignisse ermittelt werden.
  3. System nach Anspruch 1, wobei der eine oder mehrere physische Computerprozessoren so konfiguriert sind, dass sie den einen oder mehrere sensorische Stimulatoren so steuern, dass diese eine sensorische Stimulation liefern, um die Person in Reaktion auf die Gehirnaktivitätsparameter, die anzeigen, dass die Person in das dritte Schlafstadium übergegangen ist, zu wecken.
EP15804605.2A 2014-12-03 2015-11-24 System zur steigerung des erholungswertes einer schlafpause Active EP3226966B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462086934P 2014-12-03 2014-12-03
PCT/IB2015/059057 WO2016087983A1 (en) 2014-12-03 2015-11-24 System and method for increasing the restorative value of a nap

Publications (2)

Publication Number Publication Date
EP3226966A1 EP3226966A1 (de) 2017-10-11
EP3226966B1 true EP3226966B1 (de) 2018-10-24

Family

ID=54780378

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15804605.2A Active EP3226966B1 (de) 2014-12-03 2015-11-24 System zur steigerung des erholungswertes einer schlafpause

Country Status (5)

Country Link
US (1) US10537704B2 (de)
EP (1) EP3226966B1 (de)
JP (1) JP6396593B2 (de)
CN (1) CN106999697B (de)
WO (1) WO2016087983A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11052220B2 (en) * 2016-06-27 2021-07-06 Koninklijke Philips N.V. System and method for adjusting the volume of auditory stimulation during sleep based on sleep depth latencies
EP3558099B1 (de) * 2016-12-22 2021-06-30 Koninklijke Philips N.V. System zur ausgabe eines indikators, der für die wirkungen der an ein schlafendes subjekt abgegebenen stimulation repräsentativ ist
EP3562382B1 (de) * 2016-12-28 2023-10-04 Koninklijke Philips N.V. System zum bestimmen, ob ein subjekt wahrscheinlich durch therapeutische stimulationen während schlafsitzungen gestört wird
US10939866B2 (en) * 2017-12-12 2021-03-09 Koninklijke Philips N.V. System and method for determining sleep onset latency
US11123009B2 (en) * 2017-12-21 2021-09-21 Koninklijke Philips N.V. Sleep stage prediction and intervention preparation based thereon
US11116935B2 (en) * 2018-05-10 2021-09-14 Koninklijke Philips N.V. System and method for enhancing sensory stimulation delivered to a user using neural networks
CN113677270A (zh) * 2019-03-28 2021-11-19 皇家飞利浦有限公司 基于额叶脑活动监测传感器的信息增强深度睡眠
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
JP7378072B2 (ja) * 2019-07-10 2023-11-13 パナソニックＩｐマネジメント株式会社 仮眠評価装置、仮眠評価システム、仮眠評価方法、及びプログラム
WO2021115939A1 (en) * 2019-12-09 2021-06-17 Koninklijke Philips N.V. Method and system for enhancement of slow wave activity and personalized measurement thereof
WO2021115889A1 (en) * 2019-12-09 2021-06-17 Koninklijke Philips N.V. Systems for delivering sensory stimulation to facilitate sleep onset

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002065901A2 (en) * 2000-12-29 2002-08-29 Ares Medical, Inc. Sleep apnea risk evaluation
RU2330607C2 (ru) * 2001-06-13 2008-08-10 Компьюмедикс Лимитед Способ и устройство для мониторинга сознания
WO2004075714A2 (en) * 2003-02-28 2004-09-10 Cornel Lustig Device for manipulating the state of alertness
US8606356B2 (en) * 2003-09-18 2013-12-10 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
US7041049B1 (en) 2003-11-21 2006-05-09 First Principles, Inc. Sleep guidance system and related methods
US20060293608A1 (en) * 2004-02-27 2006-12-28 Axon Sleep Research Laboratories, Inc. Device for and method of predicting a user's sleep state
US20070249952A1 (en) * 2004-02-27 2007-10-25 Benjamin Rubin Systems and methods for sleep monitoring
US7593767B1 (en) * 2006-06-15 2009-09-22 Cleveland Medical Devices Inc Ambulatory sleepiness and apnea propensity evaluation system
WO2008039930A2 (en) 2006-09-28 2008-04-03 Wisconsin Alumni Research Foundation Method and apparatus for promoting restorative sleep
US20100090798A1 (en) * 2006-09-29 2010-04-15 Koninklijke Philips Electronics N.V. Template synthesis for ecg/ppg based biometrics
WO2009042172A2 (en) * 2007-09-26 2009-04-02 Medtronic, Inc. Frequency selective monitoring of physiological signals
EP2045690A1 (de) * 2007-10-04 2009-04-08 Koninklijke Philips Electronics N.V. Verbesserungen im Zusammenhang mit Gehirncomputerschnittstellen
WO2009112944A2 (en) 2008-03-11 2009-09-17 Toyota Jidosha Kabushiki Kaisha Sleep control device and control method therefor
US8628462B2 (en) * 2008-10-07 2014-01-14 Advanced Brain Monitoring, Inc. Systems and methods for optimization of sleep and post-sleep performance
US8784293B2 (en) 2008-10-07 2014-07-22 Advanced Brain Monitoring, Inc. Systems and methods for optimization of sleep and post-sleep performance
JP2010220649A (ja) * 2009-03-19 2010-10-07 Toyota Motor Corp 睡眠装置及び睡眠維持方法
AU2010255354A1 (en) * 2009-06-04 2012-02-02 Koninklijke Philips Electronics, N.V. Method and system for providing behavioural therapy for insomnia
EP2543027B1 (de) * 2009-12-31 2016-08-24 Nightbalance B.V. Vorrichtung zur Überwachung der Schlafposition
JP2012000226A (ja) * 2010-06-16 2012-01-05 Aisin Seiki Co Ltd 睡眠制御装置
US8382484B2 (en) * 2011-04-04 2013-02-26 Sheepdog Sciences, Inc. Apparatus, system, and method for modulating consolidation of memory during sleep
JP5741471B2 (ja) * 2012-02-10 2015-07-01 トヨタ自動車株式会社 睡眠制御装置
CN104955385B (zh) * 2013-01-29 2018-03-02 皇家飞利浦有限公司 增大睡眠分阶的准确性的感官刺激
US9993610B2 (en) 2013-01-29 2018-06-12 Koninklijke Philips N.V. Brain-wave based closed-loop sensory stimulation to induce sleep
US9872968B2 (en) * 2013-04-17 2018-01-23 Sri International Biofeedback virtual reality sleep assistant
WO2014170881A1 (en) * 2013-04-19 2014-10-23 Koninklijke Philips N.V. System and method for sleep session management based on slow wave sleep activity in a subject
EP2904969B1 (de) * 2014-02-11 2022-01-05 Sorin CRM SAS Vorrichtung zur behandlung des schlafapnoe-syndroms bei einem patienten durch kinästhetische stimulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
WO2016087983A1 (en) 2016-06-09
EP3226966A1 (de) 2017-10-11
CN106999697B (zh) 2020-10-27
JP6396593B2 (ja) 2018-09-26
US10537704B2 (en) 2020-01-21
US20180311462A1 (en) 2018-11-01
JP2018500968A (ja) 2018-01-18
CN106999697A (zh) 2017-08-01

Similar Documents

Publication Publication Date Title
EP3226966B1 (de) System zur steigerung des erholungswertes einer schlafpause
EP2986209B1 (de) Einstellung der sensorischen stimulationsintensität zur verbesserung der langsamwellenaktivität im schlaf
EP3729445B1 (de) Schlafstufenvorhersage und darauf basierende vorbereitung zum eingreifen
EP3102094B1 (de) System und verfahren zur bestimmung der sensorischen stimulation einer person während einer schlafsitzung
US10137276B2 (en) System and method for sleep session management based on slow wave sleep activity in a subject
US10080860B2 (en) System and method for determining timing of sensory stimulation during sleep
US10729875B2 (en) System and method for adjusting duration of sensory stimulation during sleep to enhance slow wave activity
EP3474936B1 (de) System zur einstellung der intensität von sensorischer stimulation während des schlafes auf der grundlage von schlaftiefelatenzen
EP2950868B1 (de) System für verbesserte wissenskonsolidierung durch langsamwelleninduktion im schlaf und sensorische kontextneuerstellung
AU2014210846B2 (en) Sensory stimuli to increase accuracy of sleep staging
CN106488740B (zh) 用于基于睡眠纺锤波调节睡眠期间的感觉刺激的强度的系统和方法
US10524682B2 (en) System and method for determining and displaying sleep restoration levels
EP3229662B1 (de) System zur einstellung von kriterien zur detektion langsamer wellen

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20170703

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: A61B 5/0484 20060101ALI20180413BHEP

Ipc: A61M 21/02 20060101ALI20180413BHEP

Ipc: A61M 21/00 20060101ALI20180413BHEP

Ipc: A61B 5/048 20060101ALI20180413BHEP

Ipc: A61N 1/36 20060101AFI20180413BHEP

Ipc: A61B 5/00 20060101ALI20180413BHEP

INTG Intention to grant announced

Effective date: 20180516

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1055980

Country of ref document: AT

Kind code of ref document: T

Effective date: 20181115

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602015018832

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20181024

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1055980

Country of ref document: AT

Kind code of ref document: T

Effective date: 20181024

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190124

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190224

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190124

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190224

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190125

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602015018832

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181124

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20181130

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181130

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181130

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20190725

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181124

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181124

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181024

Ref country code: MK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181024

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20151124

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20191124

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191124

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20231123

Year of fee payment: 9

Ref country code: DE

Payment date: 20231127

Year of fee payment: 9