EP3220935A4 - Isoform-specific calpain inhibitors, methods of identification, and uses thereof - Google Patents

Isoform-specific calpain inhibitors, methods of identification, and uses thereof Download PDF

Info

Publication number
EP3220935A4
EP3220935A4 EP15859500.9A EP15859500A EP3220935A4 EP 3220935 A4 EP3220935 A4 EP 3220935A4 EP 15859500 A EP15859500 A EP 15859500A EP 3220935 A4 EP3220935 A4 EP 3220935A4
Authority
EP
European Patent Office
Prior art keywords
isoform
identification
methods
calpain inhibitors
specific calpain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15859500.9A
Other languages
German (de)
French (fr)
Other versions
EP3220935A2 (en
Inventor
Michel Baudry
Xiaoning Bi
Steve STANDLEY
Lyna LUO
Yubin Wang
Guoqi ZHU
Victor BRIZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Western University of Health Sciences
Original Assignee
Western University of Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Western University of Health Sciences filed Critical Western University of Health Sciences
Publication of EP3220935A2 publication Critical patent/EP3220935A2/en
Publication of EP3220935A4 publication Critical patent/EP3220935A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP15859500.9A 2014-11-11 2015-11-11 Isoform-specific calpain inhibitors, methods of identification, and uses thereof Withdrawn EP3220935A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462078221P 2014-11-11 2014-11-11
PCT/US2015/060157 WO2016077461A2 (en) 2014-11-11 2015-11-11 Isoform-specific calpain inhibitors, methods of identification, and uses thereof

Publications (2)

Publication Number Publication Date
EP3220935A2 EP3220935A2 (en) 2017-09-27
EP3220935A4 true EP3220935A4 (en) 2018-12-26

Family

ID=55955254

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15859500.9A Withdrawn EP3220935A4 (en) 2014-11-11 2015-11-11 Isoform-specific calpain inhibitors, methods of identification, and uses thereof

Country Status (7)

Country Link
US (1) US20190030114A1 (en)
EP (1) EP3220935A4 (en)
JP (1) JP2017538681A (en)
CN (1) CN107018651A (en)
AU (1) AU2015346371A1 (en)
CA (1) CA2963684A1 (en)
WO (1) WO2016077461A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113228201B (en) * 2018-08-13 2023-03-07 健康科学西部大学 Calpain-2selective inhibitor compounds for the treatment of glaucoma
JP7138934B2 (en) * 2018-10-11 2022-09-20 学校法人常翔学園 Pharmaceutical composition containing an apelin receptor agonist having retinal neuroprotective action
WO2021163631A1 (en) * 2020-02-12 2021-08-19 Western University Of Health Sciences Calpain-2 inhibitor compounds and methods of treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235929B1 (en) * 1991-12-27 2001-05-22 Georgia Tech Research Corporation Tripeptide α-ketoamides
US20040248795A1 (en) * 2003-01-07 2004-12-09 Rodney Guttmann Membrane-permeable peptide capable of calpain inhibition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06504061A (en) * 1990-12-28 1994-05-12 コーテックス　ファーマシューティカルズ　インコーポレイテッド Use of calpain inhibitors in the treatment and prevention of neurodegeneration
EP0564561A4 (en) * 1990-12-28 1994-08-10 Georgia Tech Res Inst Peptides ketoamides, ketoacids, and ketoesters
AU2001265137B2 (en) * 2000-05-30 2007-06-14 Indiana University Research And Technology Corporation Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
CN100463901C (en) * 2003-12-12 2009-02-25 千寿制药株式会社 Alpha-ketoamide derivative, and production method and use thereof
ES2331841T3 (en) * 2003-12-12 2010-01-18 Senju Pharmaceutical Co., Ltd. DERIVATIVES OF ALFA-CETOAMIDE AND METHOD OF PRODUCTION AND USE OF THE SAME.
WO2009099416A1 (en) * 2008-02-06 2009-08-13 Georgia Tech Research Corporation Heterocyclic peptide ketoamides
EP2689247B1 (en) * 2011-03-25 2016-10-05 Vib Vzw Methods for screening inhibitors of tumour associated protein aggregation.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235929B1 (en) * 1991-12-27 2001-05-22 Georgia Tech Research Corporation Tripeptide α-ketoamides
US20040248795A1 (en) * 2003-01-07 2004-12-09 Rodney Guttmann Membrane-permeable peptide capable of calpain inhibition

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BARTUS R T ET AL: "POSTISCHEMIC ADMINISTRATION OF AK275, A CALPAIN INHIBITOR, PROVIDESSUBSTANTIAL PROTECTION AGAINST FOCAL ISCHEMIC BRAIN DAMAGE", JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, NATURE PUBLISHING GROUP, US, vol. 14, 1 July 1994 (1994-07-01), pages 537 - 544, XP001019612, ISSN: 0271-678X *
DÓKUS LEVENTE E ET AL: "Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 82, 24 May 2014 (2014-05-24), pages 274 - 280, XP028872860, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2014.05.058 *
HONGYUAN CHEN ET AL: "New Tripeptide-Based Macrocyclic Calpain Inhibitors Formed by N -Alkylation of Histidine", CHEMISTRY & BIODIVERSITY, vol. 9, no. 11, 1 November 2012 (2012-11-01), CH, pages 2473 - 2484, XP055415468, ISSN: 1612-1872, DOI: 10.1002/cbdv.201200320 *
LI Z ET AL: "Novel Peptidyl alpha.-amide inhibitors of calpains and other cysteine proteases", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 39, 1 January 1996 (1996-01-01), pages 4089 - 4098, XP002180459, ISSN: 0022-2623, DOI: 10.1021/JM950541C *
ZHAOZHAO LI ET AL: "PEPTIDE ALPHA-KETO ESTER, ALPHA-KETO AMIDE, AND ALPHA-KETO ACID INHIBITORS OF CALPAINS AND OTHER CYSTEINE PROTEASES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 36, no. 22, 29 October 1993 (1993-10-29), pages 3472 - 3480, XP000565670, ISSN: 0022-2623, DOI: 10.1021/JM00074A031 *

Also Published As

Publication number Publication date
WO2016077461A2 (en) 2016-05-19
US20190030114A1 (en) 2019-01-31
CN107018651A (en) 2017-08-04
EP3220935A2 (en) 2017-09-27
JP2017538681A (en) 2017-12-28
AU2015346371A1 (en) 2017-04-27
CA2963684A1 (en) 2016-05-19
WO2016077461A3 (en) 2016-08-04

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/00 20060101ALI20180719BHEP

Ipc: A61P 27/06 20060101ALI20180719BHEP

Ipc: A01N 57/00 20060101ALI20180719BHEP

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