EP3123032A1

EP3123032A1 - Pump housing made from at least three different sinterable materials

Info

Publication number: EP3123032A1
Application number: EP15711750.8A
Authority: EP
Inventors: Stefan Schibli; Jörg-Martin GEBERT; Ulrich Hausch; Oliver Keitel
Original assignee: Heraeus Deutschland GmbH and Co KG
Current assignee: Heraeus Deutschland GmbH and Co KG
Priority date: 2014-03-24
Filing date: 2015-03-23
Publication date: 2017-02-01
Also published as: US20170102001A1; US10655631B2; US20200291951A1; DE102014004121A1; WO2015144643A1

Abstract

The invention relates to a pump housing and to a method for producing said pump housing, the pump housing (20) comprising at least one first partial region (26), at least two further partial regions (28, 28'), and at least one third partial region (30), the at least one first partial region (26) comprising at least 60 wt%, with respect to the total weight of the first partial region (26), of at least one non-magnetic material; the at least two further partial regions (28, 28') comprising each at least 25 wt%, with respect to the total weight of the respective further partial region (28, 28'), of at least one ferromagnetic material; the at least one third partial region (30) comprising a metal content in a range of 40 to 90 wt%, with respect to the total weight of the third partial region (30), and the at least one first partial region (26) and at least one of the at least two further partial regions (28, 28') being connected to each other in a bonded manner.

Description

Pump housing made of at least three different sinterable materials

The invention relates to a pumping device comprising i. an impeller; ii. a pump housing including a wall surrounding an interior region having an inlet and an outlet, the impeller being provided in the interior of the pump housing; wherein the pump housing includes at least a first portion, at least two further portions and at least a third portion; wherein the at least one first portion includes at least 60 wt .-% based on the total weight of the first portion, at least one non-magnetic material, wherein the at least two further portions each to at least 25 wt .-%, based on the total weight of the respective at least one ferromagnetic material, wherein the at least one third portion includes a metal content in a range of 40 to 90 wt .-%, based on the total weight of the third portion, wherein the wall of the pump housing in at least one plane (Q) perpendicular to the longitudinal extent of the pump housing has at least a first portion and at least two further portions, wherein the at least one first portion and at least one of the at least two further portions are connected to each other cohesively.

The invention also relates to a method for producing a pump housing, comprising the steps: a. Providing a first material; b. Providing another material; c. Forming a third material, d. Forming a Pumpengehäusevorläufers, wherein a first portion of the pump housing made of the first material and wherein at least two further portions of the pump housing are formed from the further material; and e. Treat the pump housing precursor at a temperature of at least 300 ° C. Furthermore, the invention relates to a pump housing for a pump device obtainable by the method and a housing having at least three subregions. Moreover, the invention relates to a pumping device comprising the aforementioned housing or the aforementioned pump housing. Pumping devices with rotors or impellers are known. Some pumping devices have as a conveying path for a fluid to be pumped on a pump housing in the form of a tube. This is often an impeller, which is driven for example by a motor located outside the conveyor line via a drive shaft. The pump housing is attached to the pumping device via one or more retaining elements. This type of holder may involve various disadvantages. On the one hand, an additional step for attaching the holder is needed. This increases the production costs and is resource-inefficient. Furthermore, the connection between the pump housing and the holder due to the production or due to the connection means used, eg screws or rivets, not without tension. This is because for the mounts and / or connecting means usually other materials are selected as for the pump housing. These voltages worsen the connections of the bracket with the pump housing over time. In addition, it is extremely important to be made to save space, especially for very small pumps. This is especially true for pumps that are to be implanted in a body. A space-saving design is more difficult to realize for pumps with a large number of individual parts than for a pump with a smaller number of individual parts.

Generally, it is an object of the present invention to at least partially overcome the disadvantages of the prior art.

Another object is to provide a pumping device whose materials are as biocompatible as possible, easy to process, corrosion resistant and permanently connected to each other.

Another object is to provide a pumping device that is configured as space-saving.

Another object is to provide a pumping device which can be operated in an energy-saving manner.

Furthermore, an object is to provide a voltage-free as possible pumping device, in particular with a tension-free housing as possible or Pump housing, and in particular provide a tension-free transition from the pump housing to the remaining part of the pumping device as possible.

It is also an object to provide a pumping device which has the least possible abrasion of the moving parts and their holders in use.

In addition, an object is to provide a pump housing for a pumping device which can be easily and space-savingly incorporated into other components, e.g. a component housing of the pump device can be integrated.

In addition, an object is to provide a pump housing for a pumping device that can be hermetically sealed to a component housing of the pumping device.

Furthermore, an object is to provide a housing or pump housing, which is as free as possible from internal and / or external stresses.

Furthermore, an object is to provide a method to produce a pump housing as possible cost and time saving.

It is a further object to provide a component housing that is configured as space-saving. Another object is to provide a housing that can be hermetically sealed to other components.

A first subject of the present invention is a pumping device including: i. an impeller;

ii. a pump housing including a wall surrounding an interior area with an inlet and an outlet,

wherein the impeller is provided in the interior of the pump housing; wherein the pump housing includes at least a first portion, at least two further portions and at least a third portion; wherein the at least one first subregion comprises at least 60% by weight, preferably at least 70% by weight, or preferably at least 80% by weight, based on the total weight of the first subregion, of at least one nonmagnetic material,

wherein the at least two further subregions each contain at least 25% by weight, preferably at least 40% by weight, or preferably at least 60% by weight, based on the total weight of the respective further subregion, of at least one ferromagnetic material, wherein the at least a third portion having a metal content in a range of 40 to 90 wt .-%, preferably in a range of 50 to 85 wt .-%, or preferably in a range of 60 to 80 wt .-%, based on the total weight of third subarea, includes,

wherein the wall of the pump housing in at least one plane (Q) perpendicular to the longitudinal extent of the pump housing has at least a first portion and at least two further portions,

wherein the at least one first subregion and at least one of the at least two further subregions are connected to one another in a material-bonded manner.

The pumping device according to the invention is preferably suitable for being introduced into the body of a human or an animal. The pumping device according to the invention is further preferably designed to promote body fluids such as blood, serum, plasma, interstitial fluid, saliva or urine. In particular, it is preferred to introduce the pump device according to the invention for conveying blood into the bloodstream of a human or animal. The introduction of the pumping device according to the invention may involve, for example, an implantation in the body, a placement on the body or a connection to the body.

The pump housing of the pumping device according to the invention may have any shape that would be selected by a person skilled in the art for use in a pumping device. The pump housing preferably has at least one wall of the pump housing, hereinafter also referred to as pump housing wall, on. The at least one wall of the pump housing surrounds the interior of the pump housing. The pump housing points at least two ends, wherein at least one inlet at the one end and at least one outlet at the other end are arranged. The interior of the pump housing is completely surrounded by the wall, except at the inlet and outlet of the pump housing. The interior side facing away from the pump housing is referred to as the outside of the pump housing. The pump housing preferably has an elongated shape. The pump housing is defined in its shape by a longitudinal extent and at least one cross section. A cross section of the pump housing is always determined in a plane that is perpendicular to the pump housing wall. If the pump housing wall is curved in the longitudinal extent, then a cross section is determined perpendicular to the tangent at a point on the pump housing wall. As longitudinal extension, the expansion of the pump housing in the pumping direction is considered. It is always the shortest, imaginary connection of inlet and outlet within the pump housing. The pump housing wall, also referred to as a wall, extends in the direction of the longitudinal extent of the pump housing. The at least one wall may have one or more wall surfaces. If the pump housing has more than one wall surface, these are connected to one another via corners where the wall surfaces converge. The wall, and preferably also the wall surfaces, of the pump housing preferably extend parallel to the longitudinal extent of the pump housing.

When the pump housing is tubular, the inlet is at the first end and the outlet is at the opposite end of the pump housing. At the ends of the pump housing preferably ends at least a portion of the pump housing wall. The part of the pump housing that projects beyond the interior into the environment is also referred to as the pump housing tongue. In a preferred embodiment of the pump device according to the invention, the pump housing at the first end, the inlet, a first opening to the inner region and at the other end, the outlet, a further opening to the inner region. The pump housing is fluid-conductively connected to its surroundings via inlet and outlet. The openings at the ends of the pump housing allow a flow of fluid through the interior of the pump housing. The fluid is, for example, a gas, a liquid, such as blood, or a mixture thereof. Preferably, the first opening serves as a supply line of the fluid to be conveyed into the inner region of the pump housing and the further opening serves as a discharge of the fluid to be delivered. The pump housing may have further openings, for example in the wall of the pump housing. These further openings can serve for additional supply of fluid or on the other side for the branched discharge of fluid. If the pumping device according to the invention is implanted in a body in order, for example, to support the blood circulation and thus to relieve the heart, then the pumping device according to the invention is connected via lines to blood vessels of the body.

The pump housing includes at least a first portion, at least two further portions and at least a third portion. The first, the further and the third sub-range differ from each other preferably by their composition. Furthermore, the at least one first, the further as well as the at least one third subregion differ in their shape.

The at least one first subregion preferably has at least one, particularly preferably all, of the following properties: maximum thermal stability;

- highest possible pressure resistance;

the highest possible hardness;

- highest possible resistance to acids and bases;

- the lowest possible roughness

as tension-free as possible connectivity with a metal-ceramic mixture (cermet);

the best possible sinterability with a metal or a metal-ceramic mixture (cermet);

- lowest possible electrical conductivity;

lowest possible magnetic permeability.

The at least two further subregions preferably have at least one, preferably more, more preferably all of the following properties: highest possible thermal resistance;

- highest possible pressure resistance;

the highest possible hardness;

- highest possible resistance to acids and bases; - the lowest possible roughness

the best possible sinterability with a ceramic material or a metal-ceramic mixture (cermet);

the highest possible electrical conductivity;

- the highest possible magnetic permeability.

The at least one third subregion preferably has at least one, preferably several, most preferably all of the following properties: maximum thermal stability;

- highest possible pressure resistance;

the highest possible hardness;

- highest possible resistance to acids and bases;

- the lowest possible roughness

- As tension-free connectivity with a metal-ceramic mixture

(Cermet);

the best possible sinterability with a ceramic or a metal-ceramic mixture (cermet);

the best possible connectivity to a metal;

- Best possible weldability with a metal;

lowest possible magnetic permeability.

If the at least one first, the further as well as the at least one third portion are brought together during the production of the pump housing, then a pump housing is obtained which has one or more for the at least one first partial area, the at least two further partial areas and the at least one third partial area of the listed properties. Preferably, at least a part of the at least one first partial area is connected to at least one part of the further partial areas. Furthermore, at least a part of the at least one first partial area is preferably connected to at least one part of the at least one third partial area. The connection can be an immediate connection of the respective subareas or an indirect one. The at least one first subregion and at least one of the at least two further subregions are connected to one another in a material-locking manner. Preferably, the at least one first and the at least one third portion are connected to one another in a material-locking manner. According to the invention, the at least one first partial regions and at least one of the at least two further partial regions are connected to one another in a material-locking manner.

A cohesive connection is present if the material properties of one subarea, for example of the first subarea, flow into the physical properties of another subarea, for example the further subarea or the third subarea. There is no sharp boundary between the two adjacent sections. Rather, there is a transition region in which mix the properties of the two adjacent sections. This transition region is also referred to as a mixing sub-region in the case of an indirect connection. In this mixing subarea, both the materials of one, for example the first subarea and at least partially the materials of the second, for example the further subarea or the third subarea are juxtaposed. The mixing section preferably forms a mixture of the materials and thus usually also the properties of the two mixed sections. The materials of the two subregions preferably enter into compounds at the atomic or molecular level. There are forces at the atomic or molecular level of the materials of the first and further or third subsections. Such a cohesive connection can usually be solved only by destruction of the pump housing. In most cases cohesive connections are achieved by sintering or by bonding materials. Preferably, the cohesive connection is achieved by sintering.

The at least one first portion contains at least 60 wt .-%, preferably at least 70 wt .-%, or preferably at least 90 wt .-%, or preferably to 100 wt .-%, based on the total weight of the first portion a non-magnetic material. This is preferably a non-magnetic ceramic or a non-magnetic metal. By a non-magnetic material is meant a material having a magnetic permeability of less than 2 μ. Such a material regularly has no ferromagnetic properties. A ferromagnetic material is understood as meaning a material which has a magnetic permeability of more than 2 μ.

Preferably, the at least one first portion includes the non-magnetic ceramic in a range of 60 to 100 wt%, or preferably in a range of 70 to 100 wt .-%, or preferably in a range of 80 to 100 wt .-%, based on the total weight of the first portion. Further preferably, the at least one first portion includes the non-magnetic ceramic to 100 wt .-%, based on the total weight of the first portion.

The non-magnetic ceramic can be any ceramic that would be selected by a person skilled in the art for the pumping device according to the invention. The ceramic is preferably selected from the group consisting of an oxide ceramic, a silicate ceramic, a non-oxide ceramic or a mixture of at least two thereof.

The oxide ceramic is preferably selected from the group consisting of a metal oxide, a semi-metal oxide or a mixture thereof. The metal of the metal oxide may be selected from the group consisting of aluminum, beryllium, barium, calcium, magnesium, sodium, potassium, iron, zirconium, titanium or a mixture of at least two thereof. The metal is preferably selected from the group consisting of alumina (A1 ₂ 0 _3), magnesium oxide (MgO), zirconium oxide (Zr0 _2), yttrium oxide (Y ₂ 0 _3), aluminum titanate (Al ₂ Ti0 _5), a piezoelectric ceramic such as lead Zirconate (PbZr0 ₃ ), lead titanate (PbTi0 ₃ ) and lead zirconate titanate (PZT) or a mixture of at least two thereof. The semimetal of the semimetal oxide is preferably selected from the group consisting of boron, silicon, arsenic, tellurium or a mixture of at least two thereof.

The silicate ceramic is preferably selected from the group consisting of a steatite (Mg ₃ [Si ₄ Oio (OH) ₂ ]), cordierite (Mg, Fe ²⁺ ) ₂ (Al ₂ Si) [Al ₂ Si ₄ O ₈ ]), Mullite (Al ₂ Al _{2 + 2x} Si ₂ _ _2x Oi ₀ _-x with x = oxygen vacancies per unit cell), feldspar (Ba, Ca, Na, K, NH ₄ ) (Al, B, Si) 40 s) or a mixture of at least two of them.

The non-oxide ceramic is preferably selected from the group consisting of a carbide, a nitride or a mixture thereof. The carbide is preferably selected from the group consisting of silicon carbide (SiC), boron carbide (B ₄ C), titanium carbide (TiC), tungsten carbide, cementite (Fe ₃ C). The nitride is preferably selected from the group consisting of silicon nitride (Si ₃ N ₄ ), aluminum nitride (AlN), titanium nitride (TiN), silicon aluminum oxynitride (SIALON) or a mixture of at least two thereof. The at least two further subregions contain at least 25% by weight, preferably at least 30% by weight, preferably at least 40% by weight, or preferably at least 60% by weight, based on the total weight of the further subregions, at least one ferromagnetic material. The ferromagnetic material is preferably distributed uniformly in at least one part of the at least two further subregions.

Alternatively or additionally, at least one further subregion of the at least two further subregions may have at least one first subregion and at least one second subregion. The at least one first subregion and the at least one second subregion preferably contain the ferromagnetic material in different amounts. Preferably, a plurality of first and second sub-areas alternate. The first subregions include a lower content of ferromagnetic material than the second subregions. Preferably, the first and second subregions are arranged with different content of ferromagnetic material in the form of layers in at least one of the at least two further subregions. At least two subregions, or preferably at least three or more subregions, or preferably at least five or more subregions of different contents of ferromagnetic material, preferably alternate within the at least one further subarea. Further preferably, first and second subregions alternate in layers. Preferably, at least one of the at least two subregions includes the at least one first subregion in a number in a range of 5 to 100, or preferably in a range of 10 to 80, or preferably in a range of 15 to 60. Further preferably, at least one of at least two subregions of the at least one second subregion in a number in a range of 5 to 100, or preferably in a range of 10 to 80, or preferably in a range of 15 to 60. The at least one first subregion comprising more of the ferromagnetic material includes as the at least one second sub-region, the ferromagnetic material preferably contains at least 50 wt .-%, or preferably in a range of 60 to 100 wt .-%, or preferably in a range of 70 to 95 wt .-%, or preferably in a range of 75 to 90 wt .-%, based on the total weight of the first sub-range. The at least one second subregion, with less ferromagnetic material, preferably contains the ferromagnetic material in a range of 0 to 40 wt.%, Or preferably in a range of 0 to 30 wt.%, Or preferably in a range of 0 to 20% by weight, based on the total weight of the second sub-area. More preferably, the Resistance between two adjacent first sub-regions, formed by an intermediate second sub-region, more than 1000 ohms, or preferably more than 10000 ohms, or preferably more than 100000 ohms. The resistance between two adjacent first subregions can be determined as volume resistance. In this case, the two contacted first sub-areas are not in direct contact with each other. They are separated from a second subarea.

Furthermore, the subregions including more and less ferromagnetic material preferably further include a ceramic material. The ceramic material is the same as described for the first part. The at least 25% by weight of ferromagnetic material of the at least two further subareas are determined in each case for each further subarea by averaging the content of the first subregions and the content of the second subregions of ferromagnetic material. The at least two further subregions contain on average the ferromagnetic material in a range from 25 to 100 wt.%, Or preferably in a range from 40 to 95 wt.%, Or preferably in a range from 60 to 90 wt. , relative to the total weight of the respective further subarea. In a preferred embodiment of the pump device, the second subarea is in direct contact with the first subarea. The second subregion is preferably in contact with at least 20% of the surface, preferably with at least 40%, or preferably with at least 60%, of the respective subregion with a first subregion.

Furthermore, the at least one first subregion and the at least one second subregion are configured in the form of layers. The thickness of the layers is preferably in a range of 1 to 1000 μιη, or preferably in a range of 10 to 500 μιη, or preferably in a range of 50 to 250 μιη. The at least one first sub-area and the at least one second sub-area preferably has two surfaces running parallel to one another. Preferably, at least one of the surfaces of the first subregion is in contact with at least one surface of the second subregion. This surface is also referred to as Kontaktfiäche. Preferably, the second subregion is in contact with at least 50%, preferably with at least 60%, or preferably with at least 70%, of the respective contact surface of the respective subregion with a first subregion. The at least one third portion includes a metal content in a range of 40 to 90% by weight, preferably in a range of 45 to 85% by weight, or preferably in a range of 50 to 80% by weight, based on the Total weight of the third subarea. The at least one first subregion, the at least two further subregions and the at least one third subregion can be arranged in different ways within the pump housing. Preferably, there is no direct contact between the at least one third subregion and the at least two further subregions. The at least one third subregion and the at least two further subregions are preferably separated from one another by at least one first subregion. Further preferably, in each case a third subregion is arranged at the inlet and the outlet of the pump housing of the pumping device.

The housing preferably has the shape of a tube with a straight inner wall. Projections may protrude on the outer wall of the housing, which is formed either from at least one of the at least one first partial regions or from at least one of the at least two further partial regions or from a combination of both types of partial regions. Examples of the arrangement of the various subregions in cross section, including the protuberances, are shown in FIGS. 3a, 3b, 3c, 4a and 4b.

Each transition from one subarea to another subarea can be along a straight or curved line. Alternatively or additionally, the transition from one partial area to another partial area may take place irregularly, for example in the form of one or more steps or a zigzag line.

Preferably, at least one surface of the at least one first partial region points towards the inner region of the pump housing. Furthermore, at least one surface of the at least one third subregion points toward the inner region of the pump housing. The at least one first subregion, the at least two further subregions or the at least one third subregion can each form the entire wall thickness in a cross section in the plane of the pump housing at at least one position along the longitudinal extent of the pump housing. Alternatively, one part of the wall thickness may include the first partial area and the other part of this wall thickness may include at least one further partial area or at least a third partial area. Preferred are the at least one first portion and the at least two further portions and the at least one third portion configured as sections perpendicular or parallel to the longitudinal extent of the pump housing. In a preferred embodiment of the pump housing of the pump device according to the invention, the at least one first partial area completely surrounds at least one of the at least two further partial areas. The at least one first partial area preferably completely surrounds all of the at least two further partial areas. In a preferred embodiment of the pump housing of the pumping device according to the invention, at least one surface of the first part region faces the outside of the pump housing.

In a further preferred embodiment of the pump housing of the pump device according to the invention, at least one surface of the at least one first partial area and at least one surface of at least one of the further partial areas to the outside of the pump housing.

Furthermore, at least one surface of the at least one third subregion preferably faces the inside of the pump housing. Preferably, at least one surface of the at least one third portion to the outside of the pump housing.

In a further preferred embodiment of the pump housing of the pumping device according to the invention, at least the at least two further subregions in the form of protuberances in different spatial directions are away from the preferably cylindrical main body of the pump housing. Further preferably, the protuberances are arranged in a star shape around the main body of the pump housing.

The pumping device according to the invention also includes a rotor in the form of the impeller. The impeller may be of any shape that would be selected by one skilled in the art.

The impeller preferably has a diameter in a range of 1 mm to 10 cm, preferably in a range of 3 mm to 5 cm, or preferably in a range of 5 mm to 3 cm. The impeller preferably has a thickness in a range of 0.1 to 50 mm, preferably in a range of 0.5 to 20 mm, or preferably in a range of 1 to 15 mm up. The diameter of the impeller is preferably smaller than the diameter of the pump housing in the plane of the impeller. The diameter of the impeller is preferably in a range of 1 to 10%, or preferably in a range of 1.5 to 8%, or preferably in a range of 2 to 7%, based on the diameter of the pump housing in the plane of the impeller , smaller than the diameter of the pump housing.

The impeller preferably has at least two rotor blades, preferably at least three rotor blades, or preferably at least five rotor blades. Particularly preferably, the impeller has a number of rotor blades in a range of 2 to 20, preferably in a range of 5 to 15, or preferably in a range of 8 to 13. The impeller preferably has a central axis of rotation about which the impeller can be rotated. The axis of rotation is also called the axis of rotation. The at least two rotor blades are preferably arranged symmetrically about the axis of rotation of the impeller. The impeller is preferably arranged in the interior of the pump housing, wherein the axis of rotation of the impeller is provided parallel to the longitudinal extent of the wall of the tube.

The impeller may be made of any material that would be selected by a person skilled in the art for use in the pumping device according to the invention.

The impeller includes at least one element, the element having hard magnetic properties. A hard magnetic property means that a material obtains a permanent magnetization after exposure of this material in a magnetic field. After the magnetic field has dropped, the magnetization of the hard magnetic material continues. Materials with hard magnetic properties can be used as permanent magnets. The at least one element is preferably arranged on the impeller such that the impeller is moved when the at least one element is alternately attracted or repelled by two independent electric or magnetic fields. The impeller preferably includes at least two elements with hard magnetic properties. Furthermore, by at least one optional element of the impeller in its radial but also axial alignment can be controlled. Preferably, the elements are used with hard magnetic properties to the impeller as possible without further aids, such as bearings or other fixations in the pump housing Store without contact in the pump housing. This allows a particularly low-friction and particularly low-wear operation.

The at least one element can be realized for example by at least one rotor blade, which includes a hard magnetic material. Alternatively, a hard magnetic element may be arranged on at least one rotor blade. Preferably, the hard magnetic element is provided in the core of the impeller. The at least one hard magnetic element preferably includes at least one magnetizable material, e.g. a material selected from the group consisting of iron, cobalt, nickel, chromium dioxide or a mixture of at least two thereof. The at least one element can be arranged, for example, in the form of a coating of hard magnetic material on at least one rotor blade or in the interior of the impeller. Preferably, at least 50%, or preferably at least 70%, or preferably 100% of the rotor blades comprise a hard magnetic material. Preferably, the element contains at least 10 wt .-%, or preferably at least 20 wt .-%, or preferably at least 30 wt .-%, based on the total weight of the element, a hard magnetic metal. Further preferably, the element comprises a cobalt-chromium alloy or a platinum-cobalt alloy, in particular a platinum-cobalt alloy (PtCo23) with a proportion of cobalt of 23 wt .-% based on the total weight of the alloy in a range from 10 to 100% by weight, or preferably in a range from 20 to 100% by weight, or preferably in a range from 30 to 100% by weight, based on the total weight of the element.

Further preferably, the impeller may be coated on its outside, in particular on the outer surface of the rotor blades, with a biocompatible material. Suitable biocompatible materials are described further below.

The impeller is preferably arranged in the inner region of the pump housing, which is preferably surrounded by the first portion. The impeller is preferably arranged with its axis of rotation parallel to the longitudinal extent of the wall. Furthermore, the impeller can be aligned by a magnetic field in the pump housing.

In a preferred embodiment of the pumping device according to the invention, the at least one third subregion comprises at least 60% by weight, preferably at least 70% by weight, or preferably at least 80% by weight, based on the total weight of the third subregion, at least one non-magnetic material. Preferably, the non-magnetic material includes a non-magnetic metal.

In a preferred embodiment of the pumping device according to the invention, the non-magnetic metal of the third subregion is selected from the group consisting of platinum (Pt), palladium (Pd), stainless steel (AISI 304, AISI 316 L), iridium (Ir), niobium (Nb), Molybdenum (Mo), tungsten (W), titanium (Ti), chromium (Cr), tantalum (Ta) and zirconium (Zr) or a mixture of at least two thereof. Preferably, the metal is selected from the group consisting of titanium, niobium, molybdenum, cobalt, chromium, tantalum and their alloys or a mixture of at least two thereof.

Furthermore, the at least one third subregion may comprise further materials. The further material may be selected from the group consisting of a ceramic, a cermet or a mixture thereof.

The ceramic of the third subregion can be any ceramic that would be selected by a person skilled in the art for a pumping device. The ceramic is preferably selected from the group consisting of an oxide ceramic, a silicate ceramic, a non-oxide ceramic or a mixture of at least two thereof. The ceramic of the at least one third subregion can be selected from the same group as the ceramics listed for the first subregion. The at least one third subarea preferably has the same ceramic as the at least one first subarea. The at least one third portion includes the ceramic preferably in a range of 1 to 60 wt%, or preferably in a range of 5 to 55 wt%, or preferably in a range of 10 to 45 wt% on the total weight of the third subarea. The sum of all constituents of the at least one third subregion always yields 100% by weight.

A selection for the ceramic constituents and the metallic constituents of the cermet can be composed of those which are specified for the at least one first or the at least two further partial regions.

In a preferred embodiment of the pumping device, the at least one third subregion comprises at least 5% by weight, preferably at least 7% by weight, or preferably at least 10% by weight, more metal content than the at least one first partial area, based on the total weight of the first partial area.

In a further preferred embodiment of the pumping device, the pump housing includes at least 10 wt .-%, preferably at least 15 wt .-%, or preferably at least 20 wt .-%, based on the total weight of the pump housing, more on the at least a first portion than on the at least one third subarea.

In a further preferred embodiment of the pumping device, the pump housing includes a first portion, at least two further portions and two third portions. The two third partial regions preferably extend over the entire thickness of the pump housing wall. Preferably, the two third sections are arranged at the inlet and the outlet. The at least one first partial region preferably has a width, based on the longitudinal extent of the pump housing, in a range from 1 to 100 mm, preferably in a range from 2 to 70 mm, or preferably in a range from 3 to 50 mm. The at least one third subregion preferably has a width, based on the longitudinal extent of the pump housing, in a range of 0.25 to 80 mm, preferably in a range of 0.5 to 60 mm, or preferably in a range of 1 to 40 mm on.

In a preferred embodiment of the pump device according to the invention, the pump housing includes at least one tube. Preferably, the tube is straight. Alternatively, the tube may have at least one bend. The tube is preferably closed except for the inlet and the outlet. This means that the tube preferably has no further openings apart from the two openings at the inlet and outlet. The dimensions, materials and configurations preferably correspond otherwise to those of the previously described pump housing. In a preferred embodiment of the pump device according to the invention, at least a third subregion is provided at the inlet or the outlet. Further preferably, a third subregion is provided at the inlet and the outlet. Further preferably, the pump housing includes at its two ends in each case a third portion of equal size. These are preferably at least a first Subarea in connection with each other. The two third partial regions preferably have a width in a range from 1 to 10 mm, or preferably in a range from 2 to 8 mm, or preferably in a range from 2.5 to 6 mm. Further preferably, a first portion has a width of 5 to 40 mm, preferably in a range of 10 to 30 mm, or preferably in a range of 15 to 25 mm.

Preferably, the pump housing at the inlet and / or outlet at least a different inner diameter compared to the other inner diameter of the pump housing. The different inner diameter can be achieved either by wall thicknesses of different thicknesses or by different arrangement or geometry of the third partial areas with respect to the at least one first partial area. The pump housing includes at least one cross section, which is preferably selected from the group consisting of circular, rectangular, polygonal or ellipsoidal. Preferably, the pump housing has an elongated shape at least in a first section. Furthermore, the pump housing may include at least one further portion whose shape deviates from the first portion of the pump housing.

Preferably, the total length of the pump housing is 1.5 to 10 times, preferably 2 to 9 times, or preferably 2.5 to 8.5 times longer than the diameter of the pump housing. The length of the pump housing is determined along the outer wall of the pump housing in the pumping direction. The pump housing preferably has a length in a range of 1 mm to 10 cm, or preferably in a range of 2 mm to 8 cm, or preferably in a range of 5 mm to 5 cm. The pump housing preferably has an inner diameter in a range of 0.1 to 50 mm, or preferably in a range of 0.5 to 30 mm, or preferably in a range of 1 to 20 mm.

In a preferred embodiment of the pump device according to the invention, the pump housing has a volume in a range of 0.1 cm ³ to 10 cm ³ , preferably in a range of 0.2 to 9 cm ³ , or preferably in a range of 0.5 to 5 cm ³ up. The volume of the pump housing is defined by the interior surrounded by the pump housing.

The wall of the pump housing preferably has a thickness in a range of 0.1 to 10 mm, or preferably in a range of 0.3 to 8 mm, or preferably in one Range from 0.4 to 6 mm. In the following, either wall thickness or wall thickness is used in this context. On the inner surface of the pump housing, the wall thicknesses can vary in at least one of the first, the further or the third partial regions. An increase in the wall thickness at at least one point of the pump housing may serve to maintain the impeller at least in one direction at its position in the pump housing.

The wall, in particular the at least one wall surface of the pump housing, is preferably smooth. Smooth means that the wall of the pump housing has a roughness in a range of 0.025 to 4 Ra, or preferably in a range of 0.05 to 3 Ra, or preferably in a range of 0.07 to 1 Ra. The method for determining the roughness is described in the measuring methods and is specified in DIN EN ISO 4288.

In a preferred embodiment of the pumping device according to the invention, at least part of each further subregion is surrounded by at least one electrical coil.

The impeller in the interior of the pump housing is preferably aligned by magnetic fields from the electrical coils on the outside of the pump housing. The coils preferably include an electrically conductive material. Preferably, the electrically conductive material of the coils is selected from the group consisting of iron (Fe), copper (Cu), gold (Au), silver (Ag), platinum (Pt), palladium (Pd), titanium (Ti), chromium (Cr), cobalt (Co), tungsten (W) or a mixture of at least two thereof. Further preferably, the electrically conductive material includes copper (Cu). The pumping device according to the invention preferably includes at least two coils, preferably at least three coils, or preferably at least four coils. The coils are preferably arranged on the outside of the pump housing, wherein the coils and the impeller preferably lie in one plane. They are then arranged on the outside of the pump housing around the impeller.

In a preferred embodiment of the pumping device according to the invention, the non-magnetic material of the at least one first portion selected from the group consisting of a cermet, alumina (Al ₂ O ₃ ), zirconia (Zr0 ₂ ), an alumina-containing zirconia (ATZ), a Containing zirconium oxide Aluminum oxide (ZTA), an yttrium-containing zirconium oxide (Y-TZP), aluminum nitride (A1N), magnesium oxide (MgO), a piezoceramic, barium (Zr, Tfjoxid, barium (Ce, Tfjoxid and sodium-potassium niobate, a platinum Alloy, a palladium alloy, a titanium alloy, a niobium alloy, a tantalum alloy, a molybdenum alloy, a stainless steel (AISI 304, AISI 316 L) or a mixture of at least two thereof at least a first portion always gives 100 wt .-%.

In the context of the invention, a "cermet" is understood as meaning a composite material of one or more ceramic materials in at least one metallic matrix or a composite material of one or more metallic materials in at least one ceramic matrix Powder and at least one metallic powder may be used, which may for example be treated with at least one binder and optionally at least one solvent A selection for the ceramic constituents and the metallic constituents of the cermet may be composed of those specified for the first portion A nonmagnetic cermet is a composite of a nonmagnetic ceramic and a nonmagnetic metal, as mentioned later, In the cermet, the metal is preferably still present as a metallic component and may be a ls such are proven. Because of this metallic component, a cermet usually has a higher electrical conductivity than the pure ceramics.

In a preferred embodiment of the pumping device according to the invention, the at least one first portion includes a non-magnetic metal in a range of 40 to 90 wt .-%, preferably in a range of 50 to 90 wt .-%, or preferably from 60 to 90 wt .-%, based on the total weight of at least a first portion.

In a further preferred embodiment of the pumping device according to the invention, the non-magnetic metal is selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), niobium (Nb), molybdenum (Mo), tungsten (W), Titanium (Ti), chromium (Cr), tantalum (Ta), zirconium (Zr), alloys of the aforesaid metals, gold (Au), non-magnetic stainless steel (eg AISI 304, AISI 316 L) or a mixture of at least two thereof. The non-magnetic metal may preferably be selected from the group consisting of titanium (Ti), platinum (Pt), tantalum (Ta), niobium (Nb) or a mixture of at least two thereof.

When the content of the non-magnetic metal for the at least a first portion is below 60% by weight of the first portion, the further non-magnetic material may preferably be a non-magnetic ceramic or a non-magnetic cermet as described above at least 60 wt .-% non-magnetic material, based on the total weight of the first sub-range to be supplemented. In a preferred embodiment of the pumping device according to the invention, the ferromagnetic material of the at least two further subregions is selected from the group consisting of iron (Fe), cobalt (Co), nickel (Ni), chromium dioxide (CrO ₂ ), an iron alloy, an iron Nickel alloy, iron-silicon alloy, iron-cobalt alloy, nickel alloy, aluminum-nickel alloy, cobalt alloy, cobalt-platinum alloy, cobalt-chromium alloys, a neodymium-iron-boron alloy, a samarium-cobalt alloy or a mixture of at least two thereof.

The at least two further portions of the pump housing preferably contain a metal content in a range of 25 to 90 wt .-%, preferably in a range of 40 to 85 wt .-%, or preferably in a range of 50 to 80 wt .-%, based on the total weight of the respective further subarea.

In a preferred embodiment of the pumping device according to the invention, at least one of the at least two further subregions further comprises a component selected from a ceramic, a metal or a mixture thereof. The ceramic is preferably selected from the group of ceramics which are specified for the first subregion. At least one of the at least two partial regions preferably has the same ceramic as the first partial region. The at least two further subregions preferably include the ceramic in a range of 1 to 75 wt .-%, or preferably in a range of 2 to 70 wt .-%, or preferably in a range of 5 to 60 wt .-%, based on the total weight of the respective further subarea. The further metal may include a metal that has no ferromagnetic properties. these are preferably the metals that were also specified for the first or the third sub-range. The sum of all components of the further sub-range always gives 100 wt .-%.

In a preferred embodiment of the pump device according to the invention, the further metal is at least one of the at least two further subregions selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir), niobium (Nb), molybdenum (Mo), tungsten (W), titanium (Ti), chromium (Cr), a cobalt-chromium alloy, tantalum (Ta) and zirconium (Zr) or a mixture of at least two thereof. In a preferred embodiment of the pumping device according to the invention, the at least one first portion contains less than 10 wt .-%, preferably less than 8 wt .-%, or preferably less than 5 wt .-% of metal, based on the total weight of the first portion , In a further preferred refinement of the pumping device, the at least one first partial area and / or at least one of the at least two further partial areas is connected in a materially bonded manner to at least one third partial area. Preferably, at least one first subregion is adhesively bonded to two further subregions. Furthermore, at least one first partial region is preferably connected in a material-locking manner to all other partial regions. In addition, it is preferred that the at least one first subregion is adhesively bonded to at least one third subregion. Preferably, the at least one first subregion is adhesively connected to two, or preferably to all third subregions. In a preferred embodiment of the pump device according to the invention, the pump device is at least partially surrounded by a component housing, wherein preferably at least a part of the at least one third portion of the pump device is connected to the component housing. The connection of the component housing with at least a part of the third portion of the pump housing preferably leads to a closed space between the component housing and the pump housing. Preferably, the interior of the component housing of the pumping device is hermetically sealed against the environment. The pump device according to the invention can be used in particular in a body of a human or animal user, in particular a patient. An inserted pumping device is usually exposed to a fluid of a body tissue of the body. Thus, it is usually important that neither body fluid penetrates into the medically implantable device, nor leak the fluids from the medically implantable device. In order to ensure this, the component housing of the medically implantable device, and thus also the component housing and the pump housing of the pumping device according to the invention, should have a complete impermeability, in particular to body fluids.

The pumping device according to the invention, in particular the connection of component housing with pump housing, is preferably hermetically sealed. Thus, the interior of the pumping device is hermetically sealed against the outside space. In the context of the invention, the term "hermetically sealed" means that, when used as intended, moisture and / or gases can not penetrate the hermetically sealed connection within a customary period of five years, a physical quantity for determining the tightness of a connection or a component Leakage tests can be performed by leak testing, and leak tests will be carried out with helium leak testers and / or mass spectrometers and are specified in the MÜ-STD-883G Method 1014. The maximum allowable helium leak rate will depend on the internal volume of the device under test According to the methods specified in MIL-STD-883G, Method 1014, paragraph 3.1, and taking into account the volumes and wells of the devices to be tested used in the practice of the present invention, the maximum allowable helium leakage rate for the inventive P Enclosed housing 10 ⁷ atm * cm ³ / sec. This means that the device to be tested (for example the component housing and / or the pumping device according to the invention or the component housing with the connected pump housing) has a helium leak rate of less than 1 × 10 ^-7 atm * cm ³ / sec. In a particularly advantageous embodiment, the helium leak rate of less than 1 x 10 ^"8 atm * cm ³ / sec, in particular less than 1 x ^{10" 9} atm * ³ cm / sec. For the purposes of standardization, said helium leak rates may also be converted to the equivalent standard air leak rate. The definition for the equivalent standard air leak rate (Equivalent Standard Air Leak rate) and the conversion are specified in the ISO 3530 standard. Air leak rate = 0.37 times helium leak rate.

The pump device according to the invention preferably has, in addition to the impeller, the pump housing with at least one first, at least two further partial area and at least one third partial area, a component housing in which further components of the pump device can be located. The other components of the pump device are preferably selected from the group consisting of a battery, a coil, a control unit, a vascular connection unit or a combination of at least two thereof.

In a preferred embodiment of the pumping device according to the invention, the component housing contains titanium to at least 30 wt .-%, preferably at least 50 wt .-%, or preferably at least 80 wt .-%, each based on the total weight of the component housing. More preferably, the component housing includes titanium at least

99 wt .-%, based on the total weight of the component housing. Furthermore, the component housing may preferably include at least one other metal. The other metal may be selected from the same group as the metal of the other part. The other metal is preferably selected from the group consisting of Fe, Al, V, Sn, Co, Cr, CoCr, Nb, stainless steel, Mb, Ti b or a mixture of at least two thereof. The device package may preferably contain the further metal in a range of 1 to 70 wt%, or preferably in a range of 5 to 50 wt%, or preferably in a range of 10 to 20 wt%. The sum of all components of the component housing always results

100% by weight. Suitable titanium grades are given in ASTM B265-05,: 2011, for example Grade 1 to 6.

In a preferred embodiment of the pump device according to the invention, the wall of the pump housing has a magnetic permeability of less than 2 μ, preferably less than 1.9 μ, or preferably less than 1.8 μ. Magnetic permeability is determined in accordance with standard ASTM 773,: 2009, variant 01.

In a preferred embodiment of the pump device according to the invention, a surface of the wall, which faces the interior of the pump housing, a Vickers hardness of at least 330 HV, preferably at least 350 HV, or preferred at least 370 HV on. Preferably, the entire wall has a hardness in the specified areas. At least the surface of the at least one first and the at least one third portion also have a Vickers hardness of at least 330 HV, preferably at least 350 HV, or preferably at least 370 HV. Often the hardness is not higher than 2000 HV, or preferably not higher than 1500 HV. The hardness of at least the surface of the at least one first subregion is preferably in a range from 330 to 2000 HV, or preferably in a range from 350 to 1800 HV. Furthermore, at least the surface of the at least one first partial region preferably has a hardness that is at least as great as the hardness of the rotor surfaces of the impeller. See measuring methods (DIN ISO 6507 from March 2006, test load: lKg, exposure time: 15 sec, test temperature: 23 ° C +/- FC)

Preferably, at least the surface of the at least one first portion has a hardness which is at least 20 HV, or preferably at least 30 HV, or preferably at least 40 HV higher than the hardness of Vickers rotor surfaces of the impeller. As a surface of the at least one subregion, of the at least one further subregion and of the impeller, the near-surface material layer is in a range of 0.01 to 2.5 mm, preferably in a range of 0.05 to 1.0 mm, or preferably in one Range of 0.1 to 0.5 mm, each perpendicular to the surface understood. Furthermore, at least the surface of the at least one third subregion preferably has a hardness which is at least 20 HV, or preferably at least 30 HV, or preferably at least 40 HV, higher than the hardness of Vickers of the rotor surfaces of the impeller. If a part of a further partial area points towards the inner area of the pump housing, preferably at least the surface of this at least one further partial area has a hardness which is at least 20 HV, or preferably at least 30 HV, or preferably at least 40 HV higher than that Hardness according to Vickers of the rotor surfaces of the impeller.

In a preferred embodiment of the pump device according to the invention, at least the outer surfaces of the component housing and the surface facing the inner region of the pump housing are biocompatible. This is particularly preferred when the pumping device is for implantation in a living body, such as a human or animal. Biocompatibility is determined and assessed in accordance with standard ISO 10993: 2002, Part 4. In general, the surfaces facing the interior of the pump housing and the outer surfaces of the component housing after implanting the pumping device according to the invention in a living body with the Körperfiüssigkeit come into contact. The biocompatibility of surfaces in contact with body fluid helps prevent the body from being damaged on contact with these surfaces.

Suitable biocompatible materials are all ceramics mentioned for the first subarea. A material is biocompatible if it satisfies the requirements of standard 10993-4: 2002, as mentioned in the biocompatibility measurement methods.

Another object of the present invention is a method for producing a pump housing for a pumping device comprising the steps:

a. Providing a first material;

b. Providing another material;

c. Providing a third material

d. Forming a Pumpengehäusevorläufers, wherein a first portion of the pump housing made of the first material and wherein at least two further portions of the pump housing from the further material are formed and wherein at least a third portion of the pump housing from the third

Material is formed;

e. Treat the pump housing precursor at a temperature of at least 300 ° C. The provision of the first material in step a., Of the further material in step b. and the third material in step c. can be done in any manner that the skilled person would choose for this purpose.

Forming the pump housing precursor in step d. can be done in any manner that would be selected by the person skilled in the art for the purpose of forming a first subarea and a further subarea.

In a preferred embodiment of the method, step d. a shaping process, preferably selected from the group consisting of a lithographic process, injection molding, machining, extrusion or a combination of at least two thereof.

In a lithographic process, various layers of one or more materials are sequentially introduced into a mold. The lithographic process preferably corresponds to a layered screen printing process. In the screen printing process, a sieve, consisting of a dimensionally stable as possible material, such as wood; Metal, preferably steel; a ceramic or a plastic with a selected mesh size on the object to be overlaid or over the object to be overlaid arranged. On this sieve is applied via a nozzle or from a container used for applying or superimposing pressure mass, for example in the form of a paste or a powder, and pressed with a squeegee through the mesh of the sieve. In this case, due to a pattern in the screen at different locations different amounts of pressure applied for application or superimposition can be applied. Thus, due to the geometry and arrangement of the stitches, either a uniform film of the printing material used for overlaying can be applied or areas with little or no pressure applied for application can alternate with areas with a large amount of pressure applied for application. Preferably, a uniform film of the printing material used for superimposing is transferred to the surface. The screen meshes can also be partially closed by suitably applied materials (copy layers, screen printing stencils) so that the printing composition is transferred only in defined areas with open meshes to the surface to be coated so as to obtain, for example, a defined structure such as a pattern. Furthermore, instead of screening thin films with defined openings (stencil) can be used to transfer the printing mass. By repeating this process with one and the same material or different materials, 3-D structures can be obtained.

Injection molding, or injection molding, is a molding process for at least one material to obtain a shaped solid. The person skilled in the art knows various injection molding methods and also tools and conditions used in injection molding from the prior art. The injection molding may be selected from the group consisting of a multi-component injection molding, a powder injection molding, an injection-compression molding, an extrusion injection molding, a vacuum injection molding or a combination of at least two thereof. Machining can be combined with any other molding process. When machining, a solid body is structured by using cutting tools, such as a drill or a punch. During structuring, part of the material is removed. As a result, massive bodies can be formed into hollow bodies, for example. For example, by machining into the pump housing precursor, a cavity may be formed when the pump housing precursor is solid. However, machining may also be a processing step after manufacturing a pump housing or housing. In addition to machining, polishing may also take place following the manufacture of the pump housing.

In forming the pump housing precursor in step d. A first material for forming a first portion is brought into contact with another material for forming the further portion and a third material for forming a third portion. The contacting preferably takes place in the form of injection molding, in which successively first the further material is injected into a mold made of metal and then the first and the third material. Preferably, the further material is introduced into the mold in several steps. Further preferably, a first further material with a low content of ferromagnetic material is introduced alternately to a second further material with a high content of ferromagnetic material. As already mentioned for the pumping device according to the invention, the first further material has the ferromagnetic material in a range from 20 to 100% by weight more than the second further material, based on the total weight of the second further material. The other components, such as the ceramic component of the first further and the second further material can also be taken from the description for the pumping device. The alternating shaping of first further material and second further material preferably forms the at least two further portions of the pump housing precursor. The content of ferromagnetic material results from the averaging of the content of the first further materials and the content of the second further mixture of ferromagnetic material. The first and second additional materials are formed during the treatment in step e. the sub-areas of the at least two further subareas with different content of ferromagnetic material already described in the pumping device. Depending on the design of the mold, the third material may be injected into the mold first, then the further, eg in the form of layers of first further and second further material, and finally the first material. The proportions of the first, further and third materials preferably correspond to the quantitative ratios in the first, further and third subregions, as described above in connection with the first article, the pumping device according to the invention. Furthermore, the first, the further and the third material may contain additives. Preferably, the pump housing precursor already has the shape of the pump housing after contacting. Preferably, the three materials form a continuous form. The contacting may involve one or more further steps.

As an additive, any substance may be selected which the person skilled in the art would select as an additive for the first material, the further or the third material. The additive is preferably selected from the group consisting of water, a dispersant, a binder or a mixture of at least two thereof.

The dispersant preferably contains at least one organic substance. The organic substance preferably has at least one functional group. The functional group may be a hydrophobic or a hydrophilic functional group. The functional group may be selected from the group consisting of an ammonium group, a carboxylate group, a sulfate group, a sulfonate group, an alcohol group, a multiple alcohol group, an ether group or a mixture of at least two of them. The dispersant preferably has functional groups in a range of 1 to 100, or preferably in a range of 2 to 50, or preferably in a range of 2 to 30. Preferred dispersants are from Byk-Chemie GmbH, DOLAPIX CE 64 & Zschimmer & Schwarz GmbH & Co KG under the trade name DISPERBYK ^® 60th

The binder is preferably selected from the group consisting of a methylcellulose, a thermoplastic polymer, a thermosetting polymer and a wax or a mixture of at least two thereof.

The methylcellulose is preferably selected from the group consisting of hydroxypropylmethylcellulose (HPMC), hydroxyethylmethylcellulose (HEMC), Ethylmethylcellulose (EMC) or a mixture thereof. The methylcellulose preferably includes hydroxypropylmethylcellulose (HPMC). Further preferably, the methylcellulose contains hydroxypropylmethylcellulose in a range of 80 to 100% by weight, or preferably in a range of 90 to 100% by weight, or preferably in a range of 95 to 100% by weight .-%, based on the total weight of methyl cellulose. Preferably, the methylcellulose has a content of -OCH ₃ groups in a range of 20 to 40 wt .-%, or preferably in a range of 23 to 37 wt .-%, or preferably in a range of 25 to 35 wt .-% , based on the total weight of methylcellulose. Further preferably, the methylcellulose has a content of -OC ₃ H ₆ OH groups in a range of 1 to 12 wt .-%, or preferably in a range of 3 to 9 wt .-%, or preferably in a range of 4 to 8 Wt .-%, based on the total weight of methylcellulose.

The thermoplastic polymer may be selected from the group consisting of acrylonitrile-butadiene-styrene (ABS), polyamides (PA), polylactate (PLA), polymethyl methacrylate (PMMA), polycarbonate (PC), polyethylene terephthalate (PET), polyethylene (PE), Polypropylene (PP), polystyrene (PS), polyetheretherketone (PEEK) and polyvinylchloride (PVC) or a mixture of at least two of them. The thermosetting polymer may be selected from the group consisting of an aminoplast, an epoxy resin, a phenolic resin, a polyester resin or a mixture of at least two thereof. Waxes are hydrocarbon compounds that melt above 40 ° C without decomposition. These may also include polyesters, paraffins, polyethylenes or copolymers of at least two of them. The first material for the at least one first portion includes at least one of the aforementioned additives preferably in a range of 0.1 to 10 wt%, or preferably in a range of 0.2 to 8 wt%, or preferably in one Range of 0.5 to 5 wt .-%, based on the total weight of the first material. The further material for the at least two further subregions preferably contains at least one of the abovementioned additives in an amount in a range from 0.1 to 5% by weight, or preferably in a range from 0.2 to 2% by weight, or preferably in a range of 0.3 to 1 wt .-%, each based on the total weight of the further material. The third material for the at least a third portion includes at least one of the aforementioned additives preferably in a range of 0.1 to 10 wt%, or preferably in a range of 0.2 to 8 wt%, or preferably in one Range of 0.5 to 5 wt .-%, based on the total weight of the third material.

The treatment of the pump housing precursor in step e. may be done in any manner that a person skilled in the art would select for the purpose of heating the pump housing precursor to at least 300 ° C. Preferably, at least a portion of the treatment of the pump housing precursor takes place at a temperature in a range of 300 to 2500 ° C, or in a range of 500 to 2000 ° C, or in a range of 700 to 1800 ° C. In the treatment of the Pumpengehäusevorläufers at elevated temperature preferably escapes at least a portion of the binder. There are different temperature profiles when treating in step e. the pump housing precursor from step d. possible. The treatment of the Pumpengehäusevorläufers can be done for example in an oxidative atmosphere, a reductive atmosphere or under a protective atmosphere. For example, an oxidative atmosphere may contain oxygen, such as air or an oxygen / air mixture. For example, a reductive atmosphere may contain hydrogen. A protective atmosphere preferably contains neither oxygen nor hydrogen. Examples of protective atmospheres are nitrogen, helium, argon, krypton or mixtures thereof. The choice of atmosphere may be dependent on the materials to be treated. The person skilled in the appropriate choice of the atmosphere for the mentioned materials is known. It is also preferable to successively select combinations of different atmospheres for different periods of time.

The treatment of the pump housing precursor in step e. can be done either in one step or preferably in more than one step. The pump housing precursor is preferably used in a first substep of step e. to a temperature in a range of 301 to 600 ° C, or preferably in a range of 350 to 550 ° C, or preferably in a range of 400 to 500 ° C. This first sub-step of the treatment step e. may be over a period of time in a range of 1 to 180 minutes, preferably in a range of 10 to 120 minutes, or preferably in a range of 20 to 100 minutes. This sub-step can be accomplished either by introducing the pump housing precursor from step d. done in a preheated atmosphere or by slow stepwise or steadily increased heating of the pump housing precursor. Preference is given to the treatment in the first substep of step e. of the pump housing precursor is made in one step to a temperature in a range of 301 to 600 ° C.

In a second sub-step of the treatment from step e., Which preferably follows the first sub-step, the pump housing precursor is preferably at a temperature in a range of 800 to 2500 ° C, or preferably in a range of 1000 to 2000 ° C, or preferably heated in a range of 1100 to 1800 ° C. This sub-step can be done either by introducing the Pumpengehäusevorläufers from the first sub-step of step e. in a preheated atmosphere or by slow stepwise or steadily increased heating of the pump housing precursor. Preference is given to the treatment in the second substep of step e. of the pump housing precursor in a step to a temperature in a range of 800 to 2500 ° C. The treatment of the Pumpengehäusevorläufers in the second sub-step of step e. is preferably carried out over a period in a range of 1 to 180 minutes, preferably in a range of 10 to 120 minutes, or preferably in a range of 20 to 100 minutes.

The shape of the pump housing after the manufacturing process is preferably continuous. This means that the pump housing next to the outlet and the inlet has no other openings or outlets, or other recesses. Preferably, the pump housing has a rectilinear outer surface. On the inner surface of the pump housing, the wall thicknesses can vary in at least one of the first or the further subregions. An increase in the wall thickness at at least one point of the pump housing may serve to hold the impeller at least in one direction at its position in the pump housing. The thickening of the wall thickness can either take place during the manufacturing process or subsequently. Additionally or alternatively, the pump housing may have constrictions. A pumping device according to the invention is obtainable by inserting an impeller into a pump housing, arranging electromagnets with coils around the pump housing, producing a circuit incorporating a control device and a power source, eg a battery. Preferably, the pump device according to the invention is surrounded by a component housing and the third portions of the pump housing with the Part housing cohesively connected. This can be done, for example, by a solder joint along the point of contact of the pump housing and component housing.

Another object of the present invention is a pump housing for a pumping device obtainable by the inventive method described above.

Another object of the present invention is a housing including a wall surrounding an interior area, the housing having an inlet and an outlet, the housing having at least a first portion, at least two further portions and at least a third portion; wherein the wall of the housing in at least one plane (Q) perpendicular to the longitudinal extent of the housing has at least a first portion and at least one further portion;

wherein the at least one first subregion comprises at least 60% by weight, based on the total weight of the at least one first subregion, of at least one nonmagnetic material,

wherein the at least two further subregions contain at least 25% by weight, or preferably at least 40% by weight, or preferably at least 60% by weight, based on the total weight of the at least two further subregions, of at least one ferromagnetic material, wherein the at least one third subregion contains a metal content in a range from 40 to 90% by weight, based on the total weight of the third subregion,

The housing corresponds in its shape, its composition and its other configuration of the pump housing, which has been previously described in connection with the pumping device according to the invention.

In a preferred embodiment of the housing according to the invention, the at least one first subarea and / or at least one of the at least two further subareas is connected in a materially bonded manner to at least one third subarea. Preferably, at least one first subregion is adhesively bonded to two further subregions. Farther Preferably, at least one first subregion is adhesively bonded to all other subregions. In addition, it is preferred that the at least one first subregion is adhesively bonded to at least one third subregion. Preferably, the at least one first subregion is adhesively connected to two, or preferably to all third subregions.

In a preferred embodiment of the housing, a displaceable element is provided in the housing at least in a part of the housing. Further preferred embodiments of the housing correspond to the previously described embodiments of the pump device according to the invention.

The displaceable element may be selected from the group consisting of a sphere, a cylinder, an air bubble or a combination of at least two thereof. The displaceable element preferably has a shape that corresponds to the diameter of the pump housing. The material of the displaceable element can be any that would be used by a person skilled in the art. Preferably, the displaceable element includes a metal, a polymer, a ceramic or a mixture thereof. The metal or polymer may be selected from a metal, a polymer or a ceramic as described for the first portion of the pump housing. The displaceable element may serve, for example, to be displaced by a change in the fluid flow in the housing in its position in the housing. When changing the position of the displaceable element, a current flow in a coil can be triggered and recorded by means of a current flow measurement. Another object of the present invention is a pumping device comprising at least one previously described housing or a pump housing obtainable by the method described above. measurement methods

1. Determination of hardness according to Vickers (HV):

The test loads and materials were determined according to the standard according to DIN EN ISO 6507- March 2006. The following test loads and exposure times were used: 1 kg, 15 seconds. The test temperature was 23 ° C ± 1 ° C.

2. Determination of the magnetic permeability: The magnetic permeability was determined according to the standard ASTM A773 / A773 - 01 (2009).

3. Determination of biocompatibility:

Biocompatibility is determined according to the standard of 10993-4: 2002.

4. Determination of hermetic connection:

Leak tests will be carried out with helium leak testers and / or mass spectrometers. A standard measuring method is specified in the standard MÜ-STD-883G Method 1014. The maximum allowable helium leak rate is determined depending on the internal volume of the device to be tested. According to the methods specified in paragraph 3.1 of MIL-STD-883G, Method 1014, and taking into account the volumes and cavities of the devices to be tested in the application of the present invention, the maximum allowable helium leakage rate for the pump housings 10 ⁷ according to the invention atm * cm ³ / sec or less. This means that the device to be tested (for example the component housing and / or the pumping device or the component housing with the connected pump housing) has a helium leak rate of less than 1 × 10 ^-7 atm * cm ³ / sec. For comparative purposes, said helium leak rates may also be converted to the equivalent standard air leak rate. The equivalent standard air leak rate definition and conversion are given in the ISO 3530 standard. Air leak rate = 0.37 times helium leak rate.

5. Determination of roughness: DIN EN ISO 4288. Further parameter details: Maximum probe tip radius = 2 μιη; Measuring distance = 1.25 mm; Cut-off wavelength = 250 μιη. 6. Determination of the resistance between two first subregions or layers: To determine the resistance, a cross section is made through a test specimen, so that the layers to be measured are exposed. The ground surface is cleaned to eliminate current bridges due to ground particles. In each case, one contact of a voltmeter (Benning MM 1-1) is pressed onto a respective section of the layers to be measured and the resistance is read off. This is repeated ten times and the mean of the measurements is made.

Examples

Example 1 for first material:

The first material contains 45% by weight of platinum powder from Heraeus Precious Metals GmbH & Co. KG with a particle size D50 = 50 μm and 45% by weight aluminum oxide (Al ₂ O ₃ ) from CeramTech GmbH with a particle size of D90 2 μιη and 10 wt .-% of a binder METAWAX P-50 available from Zschimmer & Schwarz GmbH & Co.KG.

Example 2 for further material:

The further material contains a mixture of 45 wt .-% of a Pt-Co-23 material from Heraeus Holding GmbH and 45 wt .-% alumina (Al ₂ O ₃ ) available from CeramTech GmbH, and 10 wt .-% of the binding agent METAWAX P-50 available from Zschimmer & Schwarz GmbH & Co.KG.

Example 3 for third material:

The third material contains a mixture of 57% by weight of a platinum powder from Heraeus Precious Metals GmbH & Co. KG with a particle size D50 = 50 μm, and 38% by weight of aluminum oxide (A1203) from CeramTech GmbH with a particle size of D90 = 2 μιη and 5 wt .-% of a binder METAWAX P-50 available from Zschimmer & Schwarz GmbH & Co. KG.

Example 4 for the first subarea: The first subarea contains 50% by weight of platinum powder from Heraeus Precious Metals GmbH & Co.KG and 50% by weight of aluminum oxide (Al ₂ O ₃ ) from CeramTech GmbH.

Example 5 for another subarea:

The further subarea contains 50 alternating layers of 60 wt .-% of a Pt-Co-23 material from Heraeus Holding GmbH and each 40 wt .-% alumina (A1 ₂ 0 ₃ ) available from CeramTech GmbH for all even-numbered layers , The odd-numbered layers consist of 100 wt .-% alumina (A1 ₂ 0 ₃ ) available from CeramTech GmbH. The even-numbered layers accordingly correspond to the first subregions of the subarea and the odd-numbered layers correspond to the second subregions of the subarea. The layers are 100 μιη thick in this example. The further subregions in this example include the ferromagnetic material on average at least 25% by weight, based on the total amount of the respective further subregions.

Example 6 for the third subarea:

The third subregion contains 60% by weight of platinum and 40% by weight of aluminum oxide (Al ₂ O ₃ ) from CeramTech GmbH.

If not specified here, the particle sizes of the materials can be found in the product data sheet, which is available from the raw materials supplier and is often included in a delivery.

The first material from Example 1 is first provided in a container according to the method according to the invention for the manufacture of a pump housing. The further material from Example 2 is also provided in a container. The third material of Example 3 is also provided in a container. In alternating order, the powders of the third, further material and first material may be placed in the mold as shown in Figure 5 and compressed with a die as shown in Figure 6. In this way, a pump housing precursor is obtained, which is first treated in a furnace at a temperature of 400 ° C and then sintered at a temperature of 1700 ° C to a pump housing with at least one first subregion with the composition according to Example 4, to obtain at least two further subregions having the composition from Example 5 and at least a third subregion having the composition from Example 6.

characters

The following is in

Figure 1 is a schematic representation of a pump device according to the invention;

Figure 2 is a schematic of a process for the preparation of a novel

Pump housing;

Figure 3a is a schematic representation of a pump housing according to the invention with a first and a plurality of further subregions adjacent to each other;

Figure 3b is a schematic representation of a pump housing according to the invention with a first and a plurality of further subregions, wherein the first surrounds the other subregions;

FIG. 3 c shows a schematic representation of a pump housing according to the invention with a first and a plurality of further subregions, wherein the subregions are designed as an alternating layer sequence;

Figure 4a is a schematic representation of a pump housing according to the invention with a first and a plurality of further subregions, wherein two third

Subareas are arranged adjacent to the first subarea;

Figure 4b is a schematic representation of a pump housing according to the invention with a plurality of first and a plurality of further sub-area adjacent to two third

Subareas arranged;

Figure 5 is a diagram of a pressing device for producing a

Pump housing precursor without punch;

FIG. 6 shows a diagram of a pressing device for producing a

Pump housing precursor with stamp; shown.

FIG. 1 schematically shows a pump device 10 which has a pump housing 20 in the form of a tube and a component housing 40. The outer surfaces 100 of the component housing 40 come into contact with the body, in particular for an implantable pump device 10, and are therefore preferably made biocompatible , The pump housing 20 has a wall 21 which surrounds an interior region 50. The to Interior 50 facing surface of the pump housing 20 is referred to as the facing surface 102. The facing surface 102 comes into contact with the fluid and is therefore preferably made biocompatible, in particular for an implantable pump device 10. In the inner region 50 of the pump housing 20 is at least one impeller 80 in the pump housing 20. The pump housing 20 has a first portion 26 in the middle of the wall 21. At the first end 22, which simultaneously defines the inlet 22 through the opening 23, the wall 21 or the pump housing 20 has a first third portion 30. On the opposite side of the pump housing 20 is the further end 24, in the form of the outlet 25, including the further opening 25. At this opening 25 also adjoins a third portion 30. Adjacent to the first portion 26 protrude two further portions 28 and 28th ^'away from the pipe upwardly and downwardly. By means of the impeller 80, a fluid in the pumping direction 240 can be pumped from the inlet 22 to the outlet 24. Between the component housing 40 and the pump housing 20 are other components, such as a battery 120 and a control unit 130. Furthermore, there are two coils 32 and 32 'in the component housing 40. The coils 32 and 32 ^' can either around the at least two further portions 28, 28 'may be arranged or located at another location in the component housing 40. The further partial regions 28, 28 'are designed as protuberances from the otherwise tubular pump housing 20.

In Figure 2a and 2b, the flow of the method for producing a pump housing is shown schematically. In step a. 200, a first material 60 is provided. The first material 60 is for example a mixture of at least two powders. The first material preferably contains the composition of Example 1.

The further material 70 is used, for example, in the form of a mixture of Example 2 in step b. 210, as shown in FIG. 2a. Alternatively, as shown in Figure 2b, the further material 70 may also be provided in the form of two different mixtures, wherein a first further material 72 is the ferromagnetic material in the form of Pt-Co-23 powder at 90% by weight and 10 Wt .-% binder METAWAX P-50 contains. The second additional material 74 contains 90% by weight of aluminum oxide (Al ₂ O ₃ ) powder and 10% by weight of the binder METAWAX P-50. The two mixtures, that is to say the first further material 72 and the second further material 74, are alternately formed in this alternative in equal amounts to the further partial region 28, 28 '. The materials 70, 72 and 74 are placed in a mold via containers. The container may each be a metal container with a sieve passage. The powder grains preferably have a round to oval extent. The particle size specification D ₅₀ means that not more than 50% of the particles are larger than the specified diameter. The particle size specification D90 means that not more than 90% of the particles are larger than the specified diameter. The grain size can be determined by various methods. The particle size is preferably determined by means of laser diffraction, light microscopy, optical single particle counting or a combination of at least two of these. Furthermore, the determination of the particle size as well as the particle size distribution is preferably carried out on the basis of individual optical evaluation of images by means of transmission electron microscopy (TEM).

The third material 75 is in the form of a mixture of Example 3 in step c. 220 provided. The container can also be a metal container with a sieve passage here.

In a step d. 230, a pump housing precursor 90 is formed from the first material 60, the further material 70 and the third material 75. Step d. 230 may be accomplished in two alternative ways to form the pump housing precursor 90. In the first alternative of step d. At first, a further subregion 28 is formed by the further material 70, or the first further material alternately with the second further material. In this case, the further material 70, or the first further material and the second further material alternately, by means of a Teflon doctor with the dimensions 10 mm * 4 mm * 2 mm and a Rakel hardness of 50 shore in a first form of an aluminum oxide ceramic printed , The first form is open on one side. Subsequently or simultaneously, the first material 60 is pressed into a further shape and the third material 75 is pressed into a third shape as described for the further material. The further form and the third form are open to one side. With a stamp made of stainless steel, the first material 60, the third material 75 and the further material 70 are compressed under a pressure of a weight of 10 kg. This results in three blanks which are treated at a temperature of 400 ° C in a stove of Heraeus Holding GmbH for 10 hours. Subsequently, the three blanks are assembled to a pump housing precursor 90 at the open sides of the mold. The pump housing precursor is treated at a temperature of 400 ° C in air. This treatment takes place in a heating oven of the company Heraeus Holding GmbH for a period of 160 min. Immediately upon completion of this treatment step, the pump housing precursor 90 is treated at a temperature of 1700 ° C in the same furnace for 180 minutes, with subregions 30 sintered at 26 and 26 at 28 to form a pump housing. The result is a pump housing in the form of a round tube of at least a first portion and at least a third portion and protuberances at least two further portions. The inner diameter of the pump housing is for example 9 mm.

In the second alternative of step d. For example, the portions 30, 26 and 28, 28 ^' are formed together in a mold 150 as shown in FIG. First, for this purpose, the material 75 for a third portion 30 is placed in the mold, then the material 60 is entered for a first portion 26 in the mold. On these first partial regions 26, material 70, for example in the form of the first further material 72 alternately with the second additional material 74, is entered into the mold for two or more further partial regions 28, 28 '. This is again followed by a first portion 26 of material 60 and a third portion 30 of material 75. Subsequently, a lid or stamp 160 made of stainless steel is pressed onto the mold 150 to compress the portions, as shown in FIG. Here, a weight of 10 kg is pressed onto the sub-area. Subsequently, the subregions 26, 28, 28 'and 30 together are first heated for 160 min in a heating oven from Heraeus Holding GmbH to 400 ° C in the mold. Immediately upon completion of this treatment step, the pump housing precursor 90 is treated at a temperature of 1700 ° C in the same furnace for 180 minutes, with subregions 30 sintered at 26 and 26 at 28 to form a pump housing. The result is a pump housing in the form of a round tube of at least a first portion and two third portions and protuberances from the tube from at least two other portions. The inner diameter of the pump housing is for example 9 mm.

FIG. 3 a shows a cross section (in a plane Q) through a pump housing 20 produced as described above. The core of the tubular pump housing 20 is formed by a first portion 26, in the four further portions 28 and 28 'protrude. The other portions 28 and 28 'form protuberances from the Pump housing 20 in all four directions, in the form of a star. If the further subregions have been shaped in the form of layers of a first further material 72 and a second further material 74, the layers are preferably formed alternately from the middle of the tube, predominantly along the direction of the protuberances 28, 28 '. An example of one of the protuberances 28, 28 'with preferred orientation with respect to the interior 50 is shown in Figure 3c. Preferably, the protuberances 28, 28 'radially to the outside of the tube center 50. The surface of the inner region 50, consequently the surface 102 facing the inner region 50, is formed in this embodiment exclusively by a first partial region 26 and optionally one or two third partial regions (not shown here).

FIG. 3b likewise shows a cross section (in the plane Q) through a pump housing 20 according to the invention. The arrangement of the other portions 28 and 28 ^' are identical to those of Figure 3a and protrude in all directions in many directions of the tubular body of the pump housing to the outside. In contrast to the further subregions 28, 28 ', the further subregions 28, 28' in the embodiment from FIG. 3b are surrounded by the first subregion 26. As a result, the entire outer surface of the pump housing 20 includes the first portion 26 and optionally one or two third portions (not shown) at the inlet and outlet.

FIG. 3c shows an example of a possible embodiment of the protuberances 28, 28 'and thus also of the first subregions 76 and the further subregions 78 of the further subregions 28, 28 ^' . The partial regions 28, 28 ^' point radially away from the inner region 50 of the tubular pump housing 20. Parallel to the radial alignment of the partial regions 28, 28 ^' , the first subregions 76 and second subregions 78 of the respective protuberances 28, 28' extend alternately. The first subregions 76 and the further subregions 78 are stacked in the upwardly facing protuberance 28. In this example, 13 first subregions 76 alternate with 12 second subregions 78. The thickness of the first subregions 76 and the further subregions 78 can vary from 1 to 1000 μm. In this example, the thickness of all subregions is 100 μιη. All protuberances on the pump housing 20 preferably have the same geometry and the same arrangement of first subregions 76 and further subregions 78. FIG. 4 a again shows a pump housing 20 with protuberances from further subregions 28, 28 'from the tubular base body of the pump housing 20. Here, the further partial regions 28 and 28 ^' all protrude through the wall thickness of the pump housing 20 as far as the inner region 50. The inner region 50 therefore has on its facing surface 102 both parts of a first partial region 26, a third partial region 30 and parts of further partial regions 28, 28 'on. The third partial regions 30 protrude at the inlet 22 and the outlet 24 beyond the first partial region 26 to the openings. The third portions 30 are in direct contact only with the first portion 26.

The embodiment from FIG. 4 b has the same shape and arrangement of the first 26 and further partial regions 28, 28 ^' , with the difference that the further partial regions 28 and 28' extend in the longitudinal extent of the pump housing 20 as far as the third partial regions 30 , As a result, in the region of the first opening 23 of the inlet 22 and in the region of the further opening 25 of the outlet 24, the three different partial regions in the form of a third partial region 30, four further partial regions 28, 28 ^' and four first partial regions 26 with each other stay in contact.

FIG. 5 shows a mold 150 after it has been filled, as described above, by the materials 60, 70 and 75 for the first partial regions 26, the further partial regions 28, 28 ^' and the third partial regions 30. The mold 150 may be, for example, a ceramic mold such as Al ₂ O ₃ .

FIG. 6 shows the mold 150 from FIG. 5 closed by a cover 160. The lid 160 may be made of stainless steel, for example.

LIST OF REFERENCE NUMBERS

10 pumping device 220 step c

20 housing, pump housing 230 step d.

21 wall 235 step e.

22 first end / inlet 240 pumping device

23 first opening

24 further end / outlet

25 more openings

26 first subarea

28, 28 ^' further partial areas / protuberance

30 third section

40 component housing

50 indoor area

60 first material

70 more material

72 first further material

74 second additional material

75 third material

76 first subarea

78 further subarea

80 impellers

90 precursor / pump housing precursor

100 outer surface

102 facing surface

1 10 electrical component

120 battery

130 control unit

150 form

152 recess

160 stamps

200 step a.

210 step b.

Claims

claims

A pumping device (10) including: i. an impeller (80);

ii. a pump housing (20) including a wall (21) surrounding an interior portion (50) having an inlet (22) and an outlet (24),

wherein the impeller (80) in the inner region (50) of the pump housing (20) is provided;

wherein the pump housing (20) at least a first portion (26), at least two further portions (28, 28 ^' ) and at least one third

Part area (30) includes;

wherein the at least one first partial region (26) contains at least 60% by weight, based on the total weight of the first partial region (26), of at least one non-magnetic material,

wherein the at least two further subregions (28, 28 ^' ) in each case at least

25 wt .-%, based on the total weight of the respective other

Partial area (28, 28 ^' ), at least one ferromagnetic material include, wherein the at least one third portion (30) has a metal content in a

Range of 40 to 90 wt .-%, based on the total weight of the third

Subarea (30), includes,

wherein the wall (21) of the pump housing (20) in at least one plane (Q) perpendicular to the longitudinal extent of the pump housing (20) at least a first portion (26, 26 ^' ) and at least two further portions (28,

28 '),

wherein the at least one first partial region (26) and at least one of the at least two further partial regions (28, 28 ^' ) are connected to one another in a material-locking manner.

2. The pumping device (10) of claim 1, wherein the at least one third portion (30) includes at least 60% by weight, based on the total weight of the third portion (30), of at least one non-magnetic material.

3. The pump device (10) according to any one of the preceding claims, wherein the pump housing (20) includes a tube.

The pumping device (10) according to any one of the preceding claims, wherein at least a third portion (30) is provided at the inlet (22) or the outlet (24), or wherein a third portion (30) at the inlet (22 ) and the outlet (24) are provided.

5. The pump device according to claim 1, wherein the at least two further subareas each include at least a first subarea and a second subarea, wherein the at least one first subarea includes more ferromagnetic material than the at least one second subarea.

6. The pump device according to the preceding claim, wherein the at least one first sub-area and the at least one second sub-area are configured as a layer.

7. The pumping device (10) according to any one of the preceding claims, wherein the pump housing (20) has a volume in a range of 0.1 cm ³ to 10 cm ³ .

8. The pump device (10) according to any one of the preceding claims, wherein at least part of each further portion (28, 28 ^' ) of at least one electrical coil (32, 32') is surrounded.

9. The pump device (10) according to one of the preceding claims, wherein the non-magnetic material of the at least one first portion (26) or the at least one third portion (30) is selected from the group consisting of a cermet, alumina (Al ₂ O ₃ ), zirconia (ZrO ₂ ), an alumina-containing zirconia (ATZ), a zirconia-containing alumina (ZTA), an yttrium-containing zirconia (Y-TZP), aluminum nitride (AlN), magnesium oxide (MgO), a Piezoceramics, barium (Zr, tfjoxide, barium (Ce, tfjoxide and sodium-potassium niobate, a platinum Alloy, a palladium alloy, a titanium alloy, a niobium alloy, a tantalum alloy, a molybdenum alloy, a stainless steel (AISI 304, AISI 316 L) or a mixture of at least two thereof.

10. The pumping device (10) according to one of the preceding claims, wherein the at least one first partial region (26) comprises a non-magnetic metal in a range from 40 to 90% by weight, based on the total weight of the at least one first partial region ( 26).

11. The pump device (10) according to one of the preceding claims, wherein the ferromagnetic material of at least one of the at least two further subregions (28, 28 ^' ) is selected from the group consisting of iron (Fe), cobalt (Co), nickel (Ni) , Chromium dioxide (CrO ₂ ), ferrite (Fe ₂ O ₃ ), an iron alloy, an iron-nickel alloy, an iron-silicon alloy, an iron-cobalt alloy, a nickel alloy, an aluminum-nickel alloy. Alloy, a cobalt alloy, a cobalt-platinum alloy, a cobalt-chromium alloys, a neodymium-iron-boron alloy, a samarium-cobalt alloy or a mixture of at least two thereof.

12. The pump device (10) according to any one of the preceding claims, wherein at least one of the at least two further portions (28, 28 ^' ) further includes a component selected from a ceramic, or another metal or a mixture thereof.

13. The pumping device (10) according to the preceding claim, wherein the further metal of at least one of the at least two further subregions (28, 28 ^' ) is selected from the group consisting of platinum (Pt), palladium (Pd), iridium (Ir ), Niobium (Nb), molybdenum (Mo), tungsten (W), titanium (Ti), chromium (Cr), a cobalt-chromium alloy, tantalum (Ta) and zirconium (Zr), or a mixture of at least two thereof ,

14. The pumping device (10) according to one of the preceding claims, wherein the at least one first partial region (26) contains less than 10% by weight, based on the total weight of the first partial region (26), of metal.

15. The pump device (10) according to one of the preceding claims, wherein the at least one first partial region (26) and / or at least one of the at least two further partial regions (28, 28 ^' ) is adhesively bonded to at least one third partial region (30) ,

16. The pump device (10) according to one of the preceding claims, wherein the pump device is at least partially surrounded by a component housing (40), wherein at least a part of the at least one third portion (30) of the pump device (10) with the component housing ( 40) is connected.

17. The pumping device (10) according to the preceding claim, wherein the component housing (40) at least 30 wt .-%, based on the total weight of the component housing (40) includes titanium.

18. The pumping device (10) according to any one of the preceding claims, wherein the wall (21) of the pump housing (20) has a magnetic permeability of less than 2 μ.

19. The pump device (10) according to any one of the preceding claims, wherein a surface (102) of the wall (21) facing the interior region (50) of the pump housing (20) has a Vickers hardness of at least 330 HV, preferably at least 350 HV, preferably at least 370 HV.

20. The pump device (10) according to any one of the preceding claims, wherein a surface (102) of the wall (21) facing the interior region (50) of the pump housing (20) has a Vickers hardness higher by at least 20 HV than the inner surface (50) of the pump housing (20) facing surface (82) of the impeller (80).

21. The pump device according to claim 1, wherein at least the outer surfaces of the component housing and the surface of the pump housing are provided with biocompatibility

22. A method of manufacturing a pump housing (20) for a pumping device (10) comprising the steps of:

a. Providing a first material (60);

b. Providing another material (70);

c. Providing a third material (76);

d. Forming a pump housing precursor (90), wherein a first portion (26) of the pump housing (20) of the first material (60) and at least two further portions (28, 28 ^' ) of the pump housing (20) of the further material (70) and wherein at least a third portion (30) of the pump housing (20) is formed from the third material (76);

e. Treat the pump housing precursor (90) at a temperature of at least 300 ° C.

23. The method of claim 22, wherein step d. includes a forming process, preferably selected from the group consisting of a lithographic process, an injection molding, a machining, an extrusion or a combination of at least two thereof.

24. A pump housing for a pumping device (10) obtainable by a method according to at least one of claims 22 or 23.

25. A housing (20) including a wall (21) surrounding an interior area (50), the housing having an inlet (22) and an outlet (24),

wherein the housing (20) has at least one first partial region (26), at least two further partial regions (28, 28 ^' ) and at least one third partial region (30);

wherein the wall (21) of the housing (20) in at least one plane (Q) perpendicular to the longitudinal extent of the housing (20) at least a first portion (26) and at least one further portion (28, 28 '); wherein the at least one first partial region (26, 26 ^' ) contains at least 60% by weight, based on the total weight of the at least one first partial region (26, 26 ^' ), of at least one non-magnetic material, wherein the at least two further subregions (28, 28 ^' ) comprise at least 25% by weight, based on the total weight of the at least two further subregions (28, 28 ^' ), of at least one ferromagnetic material,

wherein the at least one third subregion (30) contains a metal content in a range of 40 to 90% by weight, based on the total weight of the third subregion (30),

26. The housing (20) according to claim 25, wherein the at least one first partial region (26) and / or at least one of the at least two further partial regions (28, 28 ^' ) is adhesively bonded to at least one third partial region (30).

27. The housing (20) according to any one of claims 25 or 26, wherein in the housing (20) at least in a part of the housing (20) is provided a displaceable element.

28. A pump device (10) comprising at least one housing (20) according to claim 25, 26 or 27, or a pump housing (20) obtainable by a method according to at least one of claims 22 or 23.