EP3107546A4 - Therapeutische verfahren mit noribogain und verwandten verbindungen - Google Patents

Therapeutische verfahren mit noribogain und verwandten verbindungen Download PDF

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Publication number
EP3107546A4
EP3107546A4 EP15751574.3A EP15751574A EP3107546A4 EP 3107546 A4 EP3107546 A4 EP 3107546A4 EP 15751574 A EP15751574 A EP 15751574A EP 3107546 A4 EP3107546 A4 EP 3107546A4
Authority
EP
European Patent Office
Prior art keywords
noribogaine
related compounds
therapeutic methods
methods employing
employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP15751574.3A
Other languages
English (en)
French (fr)
Other versions
EP3107546A2 (de
Inventor
Lawrence Friedhoff
Emeline Maillet
Holger Weis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DemeRx Inc
Original Assignee
DemeRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/019692 external-priority patent/WO2015126434A1/en
Priority claimed from US14/195,822 external-priority patent/US9345711B2/en
Priority claimed from US14/485,514 external-priority patent/US20150231147A1/en
Application filed by DemeRx Inc filed Critical DemeRx Inc
Publication of EP3107546A2 publication Critical patent/EP3107546A2/de
Publication of EP3107546A4 publication Critical patent/EP3107546A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP15751574.3A 2014-02-18 2015-02-17 Therapeutische verfahren mit noribogain und verwandten verbindungen Pending EP3107546A4 (de)

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
US201461941387P 2014-02-18 2014-02-18
US201461941390P 2014-02-18 2014-02-18
US201461945746P 2014-02-27 2014-02-27
PCT/US2014/019692 WO2015126434A1 (en) 2014-02-18 2014-02-28 Methods for acute and long-term treatment of drug addiction
US14/195,822 US9345711B2 (en) 2014-02-18 2014-03-03 Methods for acute and long-term treatment of drug addiction
US201461952733P 2014-03-13 2014-03-13
US201461952744P 2014-03-13 2014-03-13
US201461952731P 2014-03-13 2014-03-13
US201461952727P 2014-03-13 2014-03-13
US201461952738P 2014-03-13 2014-03-13
US201461952741P 2014-03-13 2014-03-13
US201462005847P 2014-05-30 2014-05-30
US201462005858P 2014-05-30 2014-05-30
US201462005841P 2014-05-30 2014-05-30
US201462005851P 2014-05-30 2014-05-30
US201462005855P 2014-05-30 2014-05-30
US14/292,632 US20150231146A1 (en) 2014-02-18 2014-05-30 Methods for acute and long-term treatment of drug addiction
US201462007346P 2014-06-03 2014-06-03
US201462024388P 2014-07-14 2014-07-14
US201462033538P 2014-08-05 2014-08-05
US201462035335P 2014-08-08 2014-08-08
US14/485,514 US20150231147A1 (en) 2014-02-18 2014-09-12 Methods for acute and long-term treatment of drug addiction
PCT/US2015/016186 WO2015126836A2 (en) 2014-02-18 2015-02-17 Therapeutic methods employing noribogaine and related compounds

Publications (2)

Publication Number Publication Date
EP3107546A2 EP3107546A2 (de) 2016-12-28
EP3107546A4 true EP3107546A4 (de) 2017-10-25

Family

ID=53879225

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15751574.3A Pending EP3107546A4 (de) 2014-02-18 2015-02-17 Therapeutische verfahren mit noribogain und verwandten verbindungen

Country Status (10)

Country Link
EP (1) EP3107546A4 (de)
JP (1) JP2017506244A (de)
KR (1) KR20160124829A (de)
CN (1) CN106413718A (de)
AU (2) AU2015219172A1 (de)
CA (2) CA3221251A1 (de)
EA (1) EA201691656A2 (de)
IL (1) IL247325A0 (de)
TW (1) TW201534306A (de)
WO (1) WO2015126836A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014143201A1 (en) 2013-03-15 2014-09-18 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
EP3915639B1 (de) * 2014-11-26 2023-06-07 DemeRx, Inc. Verfahren und zusammensetzungen zur potenzierung der wirkung von opioidanalgetika mithilfe von iboga-alkaloiden

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003127A1 (en) * 1994-07-25 1996-02-08 Nda International, Inc. A method of treating chemical dependency in mammals and a composition therefor
WO1999011250A2 (en) * 1997-09-04 1999-03-11 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US7220737B1 (en) * 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
WO2014144508A2 (en) * 2013-03-15 2014-09-18 Demerx, Inc. Method for non-toxic treatment for drug withdrawal

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153552A1 (en) * 2002-02-14 2003-08-14 Mash Deborah C. Method of treating chemical dependency in mammals and a composition therefor
MX2013000733A (es) * 2010-07-23 2013-05-30 Demerx Inc Composiciones de noribogaina.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003127A1 (en) * 1994-07-25 1996-02-08 Nda International, Inc. A method of treating chemical dependency in mammals and a composition therefor
WO1999011250A2 (en) * 1997-09-04 1999-03-11 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US7220737B1 (en) * 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
WO2014144508A2 (en) * 2013-03-15 2014-09-18 Demerx, Inc. Method for non-toxic treatment for drug withdrawal

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HEMENDRA N BHARGAVA ET AL: "Effects of noribogaine on the development of tolerance to antinociceptive action of morphine in mice", BRAIN RESEARCH, vol. 771, no. 2, 1 October 1997 (1997-10-01), AMSTERDAM, NL, pages 343 - 346, XP055406445, ISSN: 0006-8993, DOI: 10.1016/S0006-8993(97)00914-1 *
KOENIG XAVER ET AL: "Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 273, no. 2, 22 May 2013 (2013-05-22), pages 259 - 268, XP028784922, ISSN: 0041-008X, DOI: 10.1016/J.TAAP.2013.05.012 *
MICHAEL BAUMANN: "In vivo neurobiological effects of ibogaine and its O-desmethyl methabolite, 12-hydroxyibogamine (noribogaine) in rats)", 1 January 2001 (2001-01-01), XP055405640, Retrieved from the Internet <URL:http://jpet.aspetjournals.org/content/jpet/297/2/531.full.pdf> [retrieved on 20170912] *
STALLVIK MARIANNE ET AL: "Corrected QT interval during treatment with methadone and buprenorphine-Relation to doses and serum concentrations", DRUG AND ALCOHOL DEPENDENCE, ELSEVIER SCIENTIFIC PUBLISHERS, IR, vol. 129, no. 1, 16 October 2012 (2012-10-16), pages 88 - 93, XP028988598, ISSN: 0376-8716, DOI: 10.1016/J.DRUGALCDEP.2012.09.016 *

Also Published As

Publication number Publication date
KR20160124829A (ko) 2016-10-28
CA2977636A1 (en) 2015-08-27
WO2015126836A2 (en) 2015-08-27
CA2977636C (en) 2024-01-02
AU2020267217A1 (en) 2020-12-03
EP3107546A2 (de) 2016-12-28
AU2015219172A1 (en) 2016-09-29
CN106413718A (zh) 2017-02-15
TW201534306A (zh) 2015-09-16
JP2017506244A (ja) 2017-03-02
AU2020267217B2 (en) 2022-04-07
IL247325A0 (en) 2016-09-29
CA3221251A1 (en) 2015-08-27
EA201691656A2 (ru) 2017-03-31

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