EP3084422A4 - Ionenquelle für massenspektrometrie - Google Patents
Ionenquelle für massenspektrometrie Download PDFInfo
- Publication number
- EP3084422A4 EP3084422A4 EP14872093.1A EP14872093A EP3084422A4 EP 3084422 A4 EP3084422 A4 EP 3084422A4 EP 14872093 A EP14872093 A EP 14872093A EP 3084422 A4 EP3084422 A4 EP 3084422A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- mass spectrometry
- ion source
- ion
- source
- spectrometry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
- H01J49/045—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol with means for using a nebulising gas, i.e. pneumatically assisted
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0404—Capillaries used for transferring samples or ions
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
- H01J49/167—Capillaries and nozzles specially adapted therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
- G01N30/7246—Nebulising, aerosol formation or ionisation by pneumatic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/7273—Desolvation chambers
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361919125P | 2013-12-20 | 2013-12-20 | |
PCT/IB2014/002461 WO2015092501A1 (en) | 2013-12-20 | 2014-10-31 | Ion source for mass spectrometry |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3084422A1 EP3084422A1 (de) | 2016-10-26 |
EP3084422A4 true EP3084422A4 (de) | 2017-08-02 |
Family
ID=53402186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14872093.1A Withdrawn EP3084422A4 (de) | 2013-12-20 | 2014-10-31 | Ionenquelle für massenspektrometrie |
Country Status (3)
Country | Link |
---|---|
US (1) | US9870904B2 (de) |
EP (1) | EP3084422A4 (de) |
WO (1) | WO2015092501A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110446921A (zh) * | 2017-03-16 | 2019-11-12 | 株式会社岛津制作所 | 带电粒子的供给控制方法和装置 |
US10458885B2 (en) * | 2017-03-31 | 2019-10-29 | Rapiscan Systems, Inc. | Rapid desorber heating and cooling for trace detection |
JP2020527831A (ja) * | 2017-07-07 | 2020-09-10 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | エレクトロスプレーインターフェースデバイスおよび関連付けられた方法 |
EP3669395A4 (de) * | 2017-08-17 | 2021-04-21 | DH Technologies Development Pte. Ltd. | Apci-ionenquelle mit asymmetrischer sprühvorrichtung |
US11075068B2 (en) | 2017-11-20 | 2021-07-27 | Fossil Ion Technology | Ion source for analysis of low volatility species in the gas phase |
CN110085506A (zh) * | 2018-01-26 | 2019-08-02 | 广州禾信仪器股份有限公司 | 进样组件、敞开式离子源系统和质谱仪 |
GB201808949D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
GB201808932D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
GB201808890D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
GB201808912D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
GB201808894D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
GB201808893D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
US11373849B2 (en) | 2018-05-31 | 2022-06-28 | Micromass Uk Limited | Mass spectrometer having fragmentation region |
GB201808892D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
WO2019229469A1 (en) | 2018-05-31 | 2019-12-05 | Micromass Uk Limited | Mass spectrometer |
GB201808936D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
KR102132977B1 (ko) * | 2020-02-25 | 2020-07-14 | 영인에이스 주식회사 | 질량분석기 |
CN112635291A (zh) * | 2020-12-24 | 2021-04-09 | 北京瑞蒙特科技有限公司 | 一种真空离子阱质谱仪系统 |
CN113838738A (zh) * | 2021-09-14 | 2021-12-24 | 清华大学深圳国际研究生院 | 一种质谱联用多通道电喷雾微流控芯片离子源 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030168586A1 (en) * | 2001-06-08 | 2003-09-11 | Kentaro Yamaguchi | Cold spray mass spectrometric device |
US20130213150A1 (en) * | 2010-09-01 | 2013-08-22 | Dh Technologies Development Pte Ltd | Ion source for mass spectrometry |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1102462A (en) | 1963-10-31 | 1968-02-07 | Ass Elect Ind | Improvements relating to mass spectrometer ion sources |
JPS5843692B2 (ja) | 1976-06-30 | 1983-09-28 | 株式会社日立製作所 | 液体クロマトグラフと質量分析計とを結合した分析装置 |
US5412208A (en) | 1994-01-13 | 1995-05-02 | Mds Health Group Limited | Ion spray with intersecting flow |
JP4133631B2 (ja) * | 2002-08-19 | 2008-08-13 | 日本電子株式会社 | エレクトロスプレー質量分析装置 |
EP2260503B1 (de) | 2008-04-04 | 2018-10-10 | Agilent Technologies, Inc. | Elektrospray-ionenquellen für verbesserte ionisierung |
EP3030895B1 (de) * | 2013-08-07 | 2020-12-16 | DH Technologies Development PTE. Ltd. | Blasenentfernung aus einem flüssigkeitsstrom in eine massenspektrometerquelle |
-
2014
- 2014-10-31 EP EP14872093.1A patent/EP3084422A4/de not_active Withdrawn
- 2014-10-31 US US15/104,638 patent/US9870904B2/en active Active
- 2014-10-31 WO PCT/IB2014/002461 patent/WO2015092501A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030168586A1 (en) * | 2001-06-08 | 2003-09-11 | Kentaro Yamaguchi | Cold spray mass spectrometric device |
US20130213150A1 (en) * | 2010-09-01 | 2013-08-22 | Dh Technologies Development Pte Ltd | Ion source for mass spectrometry |
Non-Patent Citations (3)
Title |
---|
BRUINS ET AL: "Developments in interfacing microbore high-performance liquid chromatography with mass spectrometry (a review)", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 323, no. 1, 17 April 1985 (1985-04-17), pages 99 - 111, XP026549117, ISSN: 0021-9673, [retrieved on 19850417], DOI: 10.1016/S0021-9673(01)90374-7 * |
See also references of WO2015092501A1 * |
SMITH R D ET AL: "NEW DEVELOPMENTS IN BIOCHEMICAL MASS SPECTROMETRY: ELECTROSPRAY IONIZATION", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 9, 1 May 1990 (1990-05-01), pages 882 - 899, XP000619674, ISSN: 0003-2700, DOI: 10.1021/AC00208A002 * |
Also Published As
Publication number | Publication date |
---|---|
US9870904B2 (en) | 2018-01-16 |
EP3084422A1 (de) | 2016-10-26 |
US20170032949A1 (en) | 2017-02-02 |
WO2015092501A1 (en) | 2015-06-25 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20160615 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20170704 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 30/72 20060101ALN20170628BHEP Ipc: H01J 49/16 20060101ALI20170628BHEP Ipc: H01J 49/04 20060101AFI20170628BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
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18W | Application withdrawn |
Effective date: 20190823 |