EP3077546A4 - Identification of predictive biomarkers associated with wnt pathway inhibitors - Google Patents

Identification of predictive biomarkers associated with wnt pathway inhibitors Download PDF

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Publication number
EP3077546A4
EP3077546A4 EP14867583.8A EP14867583A EP3077546A4 EP 3077546 A4 EP3077546 A4 EP 3077546A4 EP 14867583 A EP14867583 A EP 14867583A EP 3077546 A4 EP3077546 A4 EP 3077546A4
Authority
EP
European Patent Office
Prior art keywords
identification
wnt pathway
pathway inhibitors
biomarkers associated
predictive biomarkers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14867583.8A
Other languages
German (de)
French (fr)
Other versions
EP3077546A1 (en
Inventor
Ann M. Kapoun
Chun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncomed Pharmaceuticals Inc
Original Assignee
Oncomed Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharmaceuticals Inc filed Critical Oncomed Pharmaceuticals Inc
Publication of EP3077546A1 publication Critical patent/EP3077546A1/en
Publication of EP3077546A4 publication Critical patent/EP3077546A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP14867583.8A 2013-12-02 2014-12-02 Identification of predictive biomarkers associated with wnt pathway inhibitors Withdrawn EP3077546A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361910663P 2013-12-02 2013-12-02
US201461975339P 2014-04-04 2014-04-04
PCT/US2014/068097 WO2015084808A1 (en) 2013-12-02 2014-12-02 Identification of predictive biomarkers associated with wnt pathway inhibitors

Publications (2)

Publication Number Publication Date
EP3077546A1 EP3077546A1 (en) 2016-10-12
EP3077546A4 true EP3077546A4 (en) 2017-04-26

Family

ID=53274023

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14867583.8A Withdrawn EP3077546A4 (en) 2013-12-02 2014-12-02 Identification of predictive biomarkers associated with wnt pathway inhibitors

Country Status (9)

Country Link
EP (1) EP3077546A4 (en)
JP (1) JP2017501137A (en)
CN (1) CN105829547A (en)
AU (1) AU2014357354A1 (en)
CA (1) CA2931975A1 (en)
HK (1) HK1223657A1 (en)
MX (1) MX2016007066A (en)
TW (1) TW201610168A (en)
WO (1) WO2015084808A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
US9359444B2 (en) 2013-02-04 2016-06-07 Oncomed Pharmaceuticals Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
WO2017023971A1 (en) * 2015-08-03 2017-02-09 Oncomed Pharmaceuticals, Inc. Identification of predictive biomarkers associated with wnt pathway inhibitors
RU2018113437A (en) * 2015-09-16 2019-10-17 Тобира Терапьютикс, Инк. COMBINED THERAPY USING A CENICRIVIROC FOR TREATING FIBROSIS
JP7374765B2 (en) 2016-10-26 2023-11-07 リープ セラピューティクス，インコーポレイテッド Use of beta-catenin as a biomarker to treat cancer using anti-DKK-1 antibodies
CN106990245B (en) * 2017-04-05 2018-07-31 东南大学 Detect application of the reagent of PITX1 expression quantity in preparing gastric cancer prognosis evaluation reagent kit
CN110835372B (en) * 2019-11-06 2020-12-01 上海健康医学院 A kind of targeting Frizzled7 monoclonal antibody and its preparation method and application
JP7593584B2 (en) * 2020-03-10 2024-12-03 学校法人杏林学園 Tumor cell markers and methods for detecting or harvesting tumor cells - Patents.com
CN111735949B (en) * 2020-07-17 2023-07-21 北京信诺卫康科技有限公司 Combination of Wnt7a and CA125 as biomarkers and kits for early ovarian cancer
CN115337400A (en) * 2021-05-13 2022-11-15 中国科学院分子细胞科学卓越创新中心 Reagents for diagnosing and treating tumors and uses thereof
CN113293212A (en) * 2021-06-17 2021-08-24 深圳华因康基因科技有限公司 Primer probe for detecting amplification of neuroblastoma recurrence transfer gene FZD2 and application thereof
WO2023113013A1 (en) * 2021-12-17 2023-06-22 国立大学法人京都大学 Method for selecting gene for use in estimation of possibility of onset of disease, and method for estimating possibility of onset of disease
WO2024189200A1 (en) * 2023-03-15 2024-09-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Cancer stratification and treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010101793A2 (en) * 2009-03-06 2010-09-10 University Of South Alabama Methods and compositions for the diagnosis, prognosis and treatment of cancer
US7982013B2 (en) * 2008-09-26 2011-07-19 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
WO2013086260A2 (en) * 2011-12-09 2013-06-13 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of cancer

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JP2003518920A (en) * 1999-07-02 2003-06-17 カイロン コーポレイション New human genes and gene expression products
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
DK1355919T3 (en) 2000-12-12 2011-03-14 Medimmune Llc Molecules with longer half-lives, compositions and uses thereof
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
CA2501235A1 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
US7365168B2 (en) 2002-10-15 2008-04-29 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
EP1697415A1 (en) 2003-11-12 2006-09-06 Biogen Idec MA Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
WO2005075514A2 (en) 2004-03-10 2005-08-18 Lonza Ltd. Method for producing antibodies
US20080312425A1 (en) 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
WO2007053648A2 (en) 2005-10-31 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP2061495A2 (en) 2006-09-08 2009-05-27 Genentech, Inc. Wnt antagonists and their use in the diagnosis and treatment of wnt-mediated disorders
EA018260B1 (en) 2006-09-29 2013-06-28 Онкомед Фармасьютикалз, Инк. Antibodies to human delta-like ligand 4 (dll4) and use thereof
EP2084296B1 (en) * 2006-09-29 2015-08-05 Agendia N.V. High-throughput diagnostic testing using arrays
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US8093364B2 (en) 2008-01-18 2012-01-10 Bio-Rad Laboratories, Inc. Enhanced purification of antibodies and antibody fragments by apatite chromatography
US20100169025A1 (en) * 2008-10-10 2010-07-01 Arthur William T Methods and gene expression signature for wnt/b-catenin signaling pathway
EP2523974A4 (en) 2010-01-12 2013-11-06 Oncomed Pharm Inc Wnt-binding agents and uses thereof
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7982013B2 (en) * 2008-09-26 2011-07-19 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
WO2010101793A2 (en) * 2009-03-06 2010-09-10 University Of South Alabama Methods and compositions for the diagnosis, prognosis and treatment of cancer
WO2013086260A2 (en) * 2011-12-09 2013-06-13 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FORGET M-A ET AL: "The Wnt pathway regulator DKKI is preferentially expressed in hormone-resistant breast tumours and in some common cancer types", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, GB, vol. 96, 1 January 2007 (2007-01-01), pages 646 - 653, XP003026724, ISSN: 0007-0920, [retrieved on 20070123], DOI: 10.1038/SJ.BJC.6603579 *
See also references of WO2015084808A1 *
WISSMANN C ET AL: "WIFI, A COMPONENT OF THE WNT PATHWAY, IS DOWN-REGULATED IN PROSTATE, BREAST, LUNG, AND BLADDER CANCER", JOURNAL OF PATHOLOGY, JOHN WILEY & SONS LTD, GB, vol. 201, no. 2, 1 January 2003 (2003-01-01), pages 204 - 212, XP008054942, ISSN: 0022-3417, DOI: 10.1002/PATH.1449 *

Also Published As

Publication number Publication date
JP2017501137A (en) 2017-01-12
EP3077546A1 (en) 2016-10-12
CA2931975A1 (en) 2015-06-11
HK1223657A1 (en) 2017-08-04
TW201610168A (en) 2016-03-16
WO2015084808A1 (en) 2015-06-11
AU2014357354A1 (en) 2016-06-09
MX2016007066A (en) 2016-09-08
CN105829547A (en) 2016-08-03
WO2015084808A4 (en) 2015-08-13

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