EP3061495B1 - Dispositif de commande pour dispositif de planification de traitement, procédé de commande, et programme - Google Patents

Dispositif de commande pour dispositif de planification de traitement, procédé de commande, et programme Download PDF

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Publication number
EP3061495B1
EP3061495B1 EP13896186.7A EP13896186A EP3061495B1 EP 3061495 B1 EP3061495 B1 EP 3061495B1 EP 13896186 A EP13896186 A EP 13896186A EP 3061495 B1 EP3061495 B1 EP 3061495B1
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European Patent Office
Prior art keywords
model
particular site
related information
radiation
low pass
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EP13896186.7A
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German (de)
English (en)
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EP3061495A4 (fr
EP3061495A1 (fr
Inventor
Kunio Takahashi
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Hitachi Ltd
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Hitachi Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A61N5/1037—Treatment planning systems taking into account the movement of the target, e.g. 4D-image based planning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
    • A61N5/1045—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1069—Target adjustment, e.g. moving the patient support
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1059—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using cameras imaging the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1087—Ions; Protons

Definitions

  • the present invention relates to controlling of a treatment planning apparatus, a control method, and a program.
  • tracking irradiation As a method of controlling a radiation treatment apparatus, tracking irradiation has been proposed and practically applied (for example, Patent Document 1).
  • the aforementioned tracking irradiation is a method in which positional information on a particular site (a tumor or the like) moving due to breathing and the like is acquired in real time and the radiation treatment apparatus is controlled such that the radiation treatment apparatus continuously irradiates the particular site with radiation.
  • the radiation treatment apparatus intensively irradiates the particular site with radiation through tracking irradiation, it is possible to ensure a radiation dosage at the particular site and to reduce the radiation dosage at surrounding sites.
  • a method of acquiring positional information on a particular site when performing tracking irradiation there is a method of detecting a position of a marker provided on a body surface or inside a body and calculating the positional information on the particular site from positional information on the marker.
  • Patent Document 1 Japanese Unexamined Patent Application, First Publication No. 2010-183976
  • US 2013/006036 A1 and US 2010/198101 A1 disclose tracking methods for positions of sites-of-interest for radiation therapy based on positioning models based, for example, on Kalman filtering approaches.
  • the present invention provides a control device for a treatment planning apparatus, a control method, and a program, in which positional information on the particular site can be acquired with highly improved accuracy.
  • FIG. 1 is a schematic block diagram illustrating a functional configuration of a radiation treatment system of the embodiment of the present invention.
  • a radiation treatment system 1 includes a treatment planning apparatus 11, a control device 12 for a radiation treatment apparatus, and a radiation treatment apparatus 13.
  • the radiation treatment system 1 is a system for performing radiation treatment. Specifically, the radiation treatment system 1 performs irradiation of radiation (radiation for treatment).
  • the radiation for treatment used for irradiation performed by the radiation treatment system 1 may be an electromagnetic wave such as an X-ray or may be a particle beam such as a heavy particle beam and a proton beam.
  • the radiation treatment system 1 performs irradiation of radiation through tracking irradiation.
  • the aforementioned tracking irradiation is a method in which positional information on a particular site moving due to breathing and the like is acquired in real time and the radiation treatment apparatus is controlled such that the radiation treatment apparatus continuously irradiates the particular site with radiation.
  • the aforementioned particular site is a portion such as a tumor which becomes a target of irradiation of radiation for treatment inside the body of a patient.
  • the treatment planning apparatus 11 generates a treatment plan for the radiation treatment system 1 to perform irradiation of radiation for treatment.
  • the aforementioned treatment plan is information indicating contents of controlling which the control device 12 for a radiation treatment apparatus performs with respect to the radiation treatment apparatus 13.
  • the treatment plan generated by the radiation treatment system 1 indicates a plan how to operate the radiation treatment apparatus 13 and causes the radiation treatment apparatus 13 to perform irradiation of radiation for treatment.
  • the control device 12 for a radiation treatment apparatus controls the radiation treatment apparatus 13 in accordance with the treatment plan generated by the treatment planning apparatus 11.
  • the control device 12 for a radiation treatment apparatus causes the radiation treatment apparatus 13 to perform irradiation of radiation for treatment through tracking irradiation.
  • the control device 12 for a radiation treatment apparatus is configured to include a computer.
  • the radiation treatment apparatus 13 executes irradiation of radiation for treatment in accordance with controlling of the control device 12 for a radiation treatment apparatus.
  • FIG. 2 is a schematic configuration diagram illustrating an apparatus configuration of the radiation treatment apparatus 13.
  • the radiation treatment apparatus 13 includes a turning drive device 311; an O-ring 312; a traveling gantry 313; an oscillating mechanism (gimbal mechanism) 321; an irradiation unit 330; sensor arrays 351, 361, and 362; and a couch 381.
  • the irradiation unit 330 includes a radiation irradiation device 331, a multi leaf collimator (MLC) 332, radiation sources 341 and 342 for image-capturing, and an infrared (IR) camera 391.
  • MLC multi leaf collimator
  • IR infrared
  • the turning drive device 311 causes the O-ring 312 to be supported by a base in a rotatable manner around a rotary axis A11.
  • the turning drive device 311 rotates the O-ring 312 in accordance with controlling of the control device 12 for a radiation treatment apparatus.
  • the rotary axis A11 is an axis in the vertical direction.
  • the O-ring 312 is formed to have a ring shape around a rotary axis A12.
  • the O-ring 312 supports the traveling gantry 313 in a rotatable manner around the rotary axis A12.
  • the rotary axis A12 is an axis in the longitudinal direction of the couch 381.
  • the rotary axis A12 is an axis in the horizontal direction (that is, an axis perpendicular to the vertical direction) and is orthogonal to the rotary axis A11 at an isocenter P11.
  • the rotary axis A12 is fixed with respect to the O-ring 312. In other words, the rotary axis A12 rotates around the rotary axis A11 in accordance with rotation of the O-ring 312.
  • the traveling gantry 313 is formed to have a ring shape around the rotary axis A12.
  • the traveling gantry 313 is disposed inside the O-ring 312 so as to form a concentric circle together with the O-ring 312.
  • the radiation treatment apparatus 13 further includes a traveling drive device (not illustrated), and the traveling gantry 313 rotates around the rotary axis A12 due to power from the traveling drive device.
  • the traveling gantry 313 itself rotates. Accordingly, the components such as the radiation source 341 for image-capturing, the sensor array 361, the radiation source 342 for image-capturing, and the sensor array 362 installed in the traveling gantry 313 rotate integrally.
  • the oscillating mechanism 321 is fixed to the inner side of a ring of the traveling gantry 313 and causes the irradiation unit 330 to be supported by the traveling gantry 313.
  • the oscillating mechanism 321 supports the irradiation unit 330 so as to be able to change the orientation of the irradiation unit 330.
  • the oscillating mechanism 321 changes the orientation of the irradiation unit 330 in accordance with controlling of the control device 12 for a radiation treatment apparatus. Specifically, the oscillating mechanism 321 rotates the irradiation unit 330 around a pan axis A21. In addition, the oscillating mechanism 321 rotates the irradiation unit 330 around a tilt axis A22.
  • the pan axis A21 is an axis parallel to the rotary axis A12 and is fixed to the traveling gantry 313.
  • the oscillating mechanism 321 causes the irradiation unit 330 to perform an oscillating operation side to side with respect to the rotary axis A12 (accordingly, side to side with respect to a patient T11) by rotating the irradiation unit 330 around the pan axis A21.
  • the tilt axis A22 is an axis orthogonal to the pan axis A21 and is fixed to the traveling gantry 313.
  • the oscillating mechanism 321 causes the irradiation unit 330 to perform an oscillating operation in the direction of the rotary axis A12 (accordingly, vertically with respect to the patient T11) by rotating the irradiation unit 330 around the tilt axis A22.
  • the irradiation unit 330 is disposed on the inner side of the traveling gantry 313 while being supported by the oscillating mechanism 321.
  • the irradiation unit 330 performs irradiation of radiation for treatment or radiation for image-capturing.
  • the radiation irradiation device 331 irradiates a lesion site of the patient T11 with radiation for treatment in accordance with controlling of the control device 12 for a radiation treatment apparatus.
  • the multi leaf collimator 332 blocks a portion or the entirety of radiation for treatment by opening and closing a leaf in accordance with controlling of the control device 12 for a radiation treatment apparatus. Accordingly, the multi leaf collimator 332 adjusts the irradiation field when the patient T11 is irradiated with radiation for treatment.
  • the multi leaf collimator 332 causes the shape of the irradiation field of radiation for treatment to match the shape of the lesion site by blocking a portion of radiation for treatment.
  • the multi leaf collimator 332 adjusts the irradiation field by blocking a portion or the entirety of radiation for treatment, thereby adjusting intensity of radiation for treatment.
  • the radiation source 341 for image-capturing irradiates the sensor array 361 with radiation for image-capturing (an X-ray) in accordance with controlling of the control device 12 for a radiation treatment apparatus.
  • the radiation source 342 for image-capturing irradiates the sensor array 362 with radiation for image-capturing in accordance with controlling of the control device 12 for a radiation treatment apparatus.
  • the radiation sources 341 and 342 for image-capturing are fixed to the irradiation unit 330 (for example, a casing of the multi leaf collimator 332) so as to respectively perform irradiation of radiation in orientations orthogonal to each other.
  • the sensor array 351 is disposed at a position where radiation for treatment from the radiation irradiation device 331 is directed, while being oriented toward the radiation irradiation device 331.
  • the sensor array 351 is fixed to the inner side of the ring of the traveling gantry 313.
  • the sensor array 351 receives radiation for treatment which has been transmitted through the patient T11 and the like, for the purpose of checking the irradiation position and recording the treatment.
  • the aforementioned expression "receiving radiation” denotes a state of being irradiated with radiation.
  • the sensor array 361 is disposed at a position where radiation for image-capturing from the radiation source 341 for image-capturing is directed, while being oriented toward the radiation source 341 for image-capturing.
  • the sensor array 361 is fixed to the inner side of the ring of the traveling gantry 313.
  • the sensor array 361 receives radiation for image-capturing with which the radiation source 341 for image-capturing has irradiated the patient T11 and the like and which has been transmitted through the patient T11 and the like, for the purpose of particularizing a lesion site position.
  • the sensor array 361 When the sensor array 361 receives radiation for image-capturing from the radiation source 341 for image-capturing, a radiation image can be obtained.
  • the sensor array 362 is disposed at a position where radiation for image-capturing from the radiation source 342 for image-capturing is directed, while being oriented toward the radiation source 342 for image-capturing.
  • the sensor array 362 is fixed to the inner side of the ring of the traveling gantry 313.
  • the sensor array 362 receives radiation for image-capturing with which the radiation source 342 for image-capturing has irradiated the patient T11 and the like and which has been transmitted through the patient T11 and the like, for the purpose of particularizing the lesion site position.
  • a radiation image can be obtained.
  • another radiation image can be obtained in a direction different from that of the combination of the radiation source 341 for image-capturing and the sensor array 361.
  • the couch 381 is for the patient T11 to lie on, thereby supporting the patient T11.
  • the couch 381 is installed such that the longitudinal direction is oriented toward the direction of the rotary axis A12.
  • the couch 381 can move in various directions while causing the longitudinal direction to be oriented toward the direction of the rotary axis A12.
  • the infrared (IR) camera 391 receives infrared rays and captures an infrared image.
  • the infrared camera 361 is installed so as to be oriented toward the patient T11 lying on the couch 381.
  • the infrared camera 361 captures an image of an infrared marker provided on the body surface of the patient T11 in the vicinity of the lesion site, thereby acquiring three-dimensional positional information on the infrared marker in real time.
  • the infrared camera 361 acquires the three-dimensional positional information on the infrared marker at the time thereof.
  • the infrared camera 361 acquires the three-dimensional positional information on the infrared marker.
  • the three-dimensional positional information may be acquired by causing the infrared camera 361 to perform irradiation of an infrared ray and calculating the distance to the infrared marker based on the time taken until the reflected light is received.
  • the three-dimensional positional information may be acquired by causing the infrared camera 361 to capture a stereoscopic image (image of stereogram) of the infrared marker and calculating the distance to the infrared marker based on deviation in the image.
  • FIG. 3 is a schematic block diagram illustrating a functional configuration of the control device 12 for a radiation treatment apparatus.
  • the control device 12 for a radiation treatment apparatus includes a communication unit 110, a storage unit 180, and a control unit 190.
  • the control unit 190 includes a position-related information acquisition portion 191, a teacher signal acquisition portion 192, a model generation portion 193, and a particular site position calculation portion 194.
  • the communication unit 110 communicates with the treatment planning apparatus 11 ( FIG. 1 ) and the radiation treatment apparatus 13. Particularly, the communication unit 110 receives the treatment plan transmitted by the treatment planning apparatus 11. In addition, the communication unit 110 receives the three-dimensional positional information on the infrared marker transmitted by the radiation treatment apparatus 13. Moreover, the communication unit 110 transmits a control signal generated by the control unit 190 with respect to the radiation treatment apparatus 13, to the radiation treatment apparatus 13.
  • the storage unit 180 stores various types of information. Particularly, a template for the model generation portion 193 to generate a model is stored in the storage unit 180 in advance. In addition, the storage unit 180 stores the model generated by the model generation portion 193.
  • the storage unit 180 is configured to include a storage device provided in the control device 12 for a radiation treatment apparatus.
  • the control unit 190 executes various types of functions by controlling each of the components in the control device 12 for a radiation treatment apparatus. Particularly, the control unit 190 generates a control signal with respect to the radiation treatment apparatus 13 based on the treatment plan generated by the treatment planning apparatus 11. In this case, the control unit 190 calculates the three-dimensional positional information on the particular site based on the three-dimensional positional information on the infrared marker acquired by the radiation treatment apparatus 13 (the infrared camera 361), thereby generating a control signal based on the acquired positional information.
  • execution of the control unit 190 is realized when a central processing unit (CPU) included in the control device 12 for a radiation treatment apparatus reads out a program from the storage device included in the control device 12 for a radiation treatment apparatus.
  • CPU central processing unit
  • the position-related information acquisition portion 191 acquires, in real time, the three-dimensional positional information on the infrared marker which is acquired by the infrared camera 361 and is in a form of three-dimensional coordinate information via the communication unit 110.
  • the position of the infrared marker has a correlationship with the position of the particular site. For example, in a case where the particular site is positioned at the chest or the abdomen of a patient, both the position of the particular site and the position of the infrared marker change due to breathing of the patient. Both the cycle in which the position of the particular site changes and the cycle in which the position of the infrared marker changes are approximately the same as the breathing cycle of the patient. Moreover, as the amount of change in the position of the particular site increases, the amount of change in the position of the infrared marker also tends to increase.
  • the three-dimensional positional information on the infrared marker acquired by the position-related information acquisition portion 191 is used as position-related information. Specifically, the three-dimensional positional information on the infrared marker acquired by the position-related information acquisition portion 191 is used when the particular site position calculation portion 194 calculates the three-dimensional positional information on the particular site.
  • the position-related information acquisition portion 191 acquires the position-related information related to the position of the particular site.
  • the position-related information related to the position of the particular site is not limited to the positional information on the infrared marker. Movement of a predetermined portion of a patient may be measured more directly, for example, the control device 12 for a radiation treatment apparatus may measure the height of the abdomen of the patient from the couch in real time, and the result thereof may be used as the position-related information. Otherwise, the control device 12 for a radiation treatment apparatus may measure information such as respiratory volume of a patient indicating a breathing state of the patient, in real time, and the result thereof may be used as the position-related information.
  • the teacher signal acquisition portion 192 acquires the three-dimensional positional information on the particular site in a form of the three-dimensional coordinate information. For example, the teacher signal acquisition portion 192 acquires the three-dimensional positional information on the particular site based on a two-dimensional perspective image from the combination of the radiation source 341 for image-capturing and the sensor array 361, and another two-dimensional perspective image from the combination of the radiation source 341 for image-capturing and the sensor array 361.
  • the teacher signal acquisition portion 192 acquires the three-dimensional positional information on the particular site at the time thereof. Accordingly, the three-dimensional positional information on the particular site acquired by the teacher signal acquisition portion 192 is in association with the three-dimensional positional information on the infrared marker acquired at the same time.
  • the three-dimensional positional information on the particular site acquired by the teacher signal acquisition portion 192 is used as a teacher signal (information indicating correct decision) through which the model generation portion 193 can learn a model indicating the relationship between the position of the infrared marker and the position of the particular site.
  • the three-dimensional positional information will be simply referred to as "the positional information”.
  • the model generation portion 193 generates a model outputting the position of the particular site based on the position-related information.
  • FIG. 4 is an explanatory diagram illustrating an example of a flow of a signal when a model for performing tracking irradiation is generated.
  • the infrared camera 361 acquires the positional information on the infrared marker A12 by capturing an image of the infrared marker A12.
  • the position-related information acquisition portion 191 acquires the positional information on the infrared marker A12 from the infrared camera 361.
  • the teacher signal acquisition portion 192 acquires two-dimensional positional information on the particular site A11 based on the two-dimensional perspective image captured when the sensor array 361 receives radiation from the radiation source 341 for image-capturing. Similarly, the teacher signal acquisition portion 192 acquires two-dimensional positional information on the particular site A11 based on the two-dimensional perspective image captured when the sensor array 362 receives radiation from the radiation source 342 for image-capturing. The teacher signal acquisition portion 192 acquires the three-dimensional positional information on the particular site A11 based on the two items of the acquired two-dimensional positional information.
  • the model generation portion 193 uses the three-dimensional positional information on the infrared marker A12 acquired by the position-related information acquisition portion 191 and the three-dimensional positional information on the particular site A11 acquired by the teacher signal acquisition portion 192, as data for learning, thereby learning the model for performing tracking irradiation. Specifically, through learning, the model generation portion 193 generates the model in which the three-dimensional positional information on the infrared marker A12 is input and the three-dimensional positional information on the particular site A11 is output.
  • the positional information on the infrared marker A12 is used as a respiratory signal.
  • the aforementioned respiratory signal is a signal for correcting deviation caused by breathing and the like, with respect to the positional information on the particular site.
  • the particular site position calculation portion 194 outputs the positional information on the particular site. Specifically, the particular site position calculation portion 194 applies the position-related information acquired by the position-related information acquisition portion 191 to the model generated by the model generation portion 193, and the particular site position calculation portion 194 calculates the position of the particular site, thereby outputting the result thereof as the positional information.
  • FIG. 5 is an explanatory diagram illustrating another example of the flow of the signal for acquiring positional information on a particular site when tracking irradiation is executed.
  • the infrared camera 361 captures an image of the infrared marker A12 and acquires the positional information on the infrared marker A12.
  • the position-related information acquisition portion 191 acquires the positional information on the infrared marker A12 from the infrared camera 361.
  • the particular site position calculation portion 194 causes the three-dimensional positional information on the infrared marker A12 acquired by the position-related information acquisition portion 191 to be input to the model and outputs the three-dimensional positional information on the particular site A11.
  • the model generated by the model generation portion 193 (accordingly, the model used by the particular site position calculation portion 194) is provided with a filter regulating an amount of change in the position of the particular site output by the model.
  • a filter regulating an amount of change in the position of the particular site output by the model.
  • FIG. 6 is a schematic block diagram illustrating an example of a block configuration of the template of the model used by the model generation portion 193.
  • the model generation portion 193 uses the template having the configuration illustrated in FIG. 6 or the template in which the filter regulating the amount of change in the position of the particular site as an output of the model is further added to the configuration illustrated in FIG. 6 .
  • x indicates the three-dimensional positional information on the infrared marker.
  • F(x) indicates the three-dimensional positional information on the particular site.
  • a block B11 indicates a block of differentiation.
  • the block B11 is realized by using a differentiation filter (differential filter).
  • a block B12 indicates a block in which computation is performed based on a term using x or differentiation of x.
  • Equation (1) presents the model based on the template in FIG. 6 .
  • F x a ⁇ x 2 + b ⁇ x + c ⁇ d dt x + d ⁇ d dt x 2 + e
  • d/dt indicates first order differentiation.
  • a, b, c, d, and e respectively indicate constants.
  • the constant a indicates a coefficient of a term of square of x.
  • the constant b indicates a coefficient of a term of x.
  • the constant c indicates a coefficient of a term of differentiation of x.
  • the constant d indicates a coefficient of a term of square of differentiation of x.
  • the constant e is configured to be a constant term.
  • the model generation portion 193 generates a model by determining values of the constants a to e through learning. For example, the model generation portion 193 uses optimization algorithm so as to obtain the values of the constants a to e which minimize an error between the three-dimensional positional information on the particular site calculated based on the three-dimensional positional information on the infrared marker and the teacher signal.
  • FIG. 7 is a schematic block diagram illustrating an example of the block configuration of the model used by the particular site position calculation portion 194.
  • FIG. 7 illustrates the block configuration of the model which can be obtained from the template illustrated in FIG. 6 .
  • a block B22 indicates a block in which calculation of each term is performed by using the determined values of the constants a to e and the three-dimensional positional information on the particular site is calculated.
  • FIG. 8 is a graph illustrating an example of an output of the particular site position calculation portion 194 and teacher data.
  • FIG. 8 illustrates a result in which an operation check test of a model which can be obtained through Expression (1) is performed and the output of the particular site position calculation portion 194 and the teacher data are compared with each other.
  • the horizontal axis in FIG. 8 indicates time.
  • the vertical axis indicates a displacement amount of a position of a patient in the head-foot direction (the longitudinal direction of the couch) from a reference position.
  • a line L11 indicates a teacher signal.
  • a line L12 indicates an output of the particular site position calculation portion 194.
  • Such sudden changes are not preferable in that an error with respect to the actual position of the particular site indicated in the teacher data becomes significant.
  • the control device 12 for a radiation treatment apparatus is intended to cause the radiation treatment apparatus 13 (particularly, the oscillating mechanism 321 or the multi leaf collimator 332) to perform an operation beyond the performance of the radiation treatment apparatus 13, an error occurs and irradiation of radiation is suspended.
  • FIG. 9 is a graph illustrating an example of another output of the particular site position calculation portion 194 and a position of the infrared marker.
  • the inventor of this description has compared the output of the particular site position calculation portion 194 and the position of the infrared marker in order to examine the cause of the sudden changes exemplified in FIG. 8 .
  • the horizontal axis in FIG. 9 indicates time.
  • the vertical axis indicates a displacement amount of a position of a patient in the head-foot direction (the longitudinal direction of the couch) from the reference position.
  • the vertical axis indicates a distance.
  • the line L21 indicates the position of the infrared marker.
  • the line L22 indicates the output of the particular site position calculation portion 194.
  • the line L23 indicates the distance between a beam axis and the target.
  • the sudden changes in the output of the particular site position calculation portion 194 exemplified in FIGS. 8 and 9 are errors which have occurred during a process of calculation performed by using the model and, for example, which are caused by the amount of change in the term of square of differentiation of x in Expression (1) "d ⁇ ((d/dt) x)2" which becomes greater than the actual amount of change in the particular site.
  • the amount of change in the output of the particular site position calculation portion 194 is regulated by using a low pass filter.
  • the amount of change in the output of the particular site position calculation portion 194 is simply regulated, there is a possibility that an error becomes significant in a portion other than the portions of the sudden changes.
  • FIG. 10 is a schematic block diagram illustrating an example in which the low pass filter with respect to an output of the model is provided.
  • a block B31 of the low pass filter is provided and the amount of change in the output of the particular site position calculation portion 194 is regulated, it is possible to prevent the sudden changes in the output of the particular site position calculation portion 194 from occurring during the process of calculation performed by using the model.
  • the low pass filter indicated in the block B31 corresponds to an example of a filter regulating the amount of change in the output of the particular site position calculation portion 194.
  • FIG. 11 is a schematic block diagram illustrating a first example in which the low pass filter is provided in the model.
  • the low pass filter is provided in the model.
  • the model generation portion 193 uses the template in which the low pass filter is provided in the model. In other words, the model generation portion 193 sets the parameters of the model template provided with the filter regulating the amount of change in the output of the particular site position calculation portion 194, thereby generating the model provided with the filter.
  • the model generation portion 193 sets the parameters so as to minimize an error between an output after passing through the low pass filter and the teacher signal. Accordingly, it is expected that an error between the output of the particular site position calculation portion 194 and the actual position of the particular site becomes relatively small.
  • FIG. 12 is a schematic block diagram illustrating a second example in which the low pass filter is provided in the model.
  • the block B31 of the low pass filter is provided on an entrance side in the model.
  • the low pass filter can be inserted into a position different from those in the example of FIG. 11 and the example of FIG. 12 .
  • the block B31 in place of the position of the block B31 in FIG. 12 , the block B31 may be provided on the differentiation side in the inputs (between the block B11 and the block B22 in FIG. 12 ). Otherwise, in place of the position of the block B31 in FIG. 12 , the block B31 may be provided inside the block B22.
  • the low pass filter may be provided with respect to an input to any one of the terms in Expression (1) or with respect to an output to any one of the terms therein.
  • the low pass filters may be provided in a plurality of portions in the model.
  • the model generation portion 193 may generate a plurality of the models in each of which the filter is provided at a position different from that in each of the others and may select any one of the models.
  • the model generation portion 193 sets the parameters of the template having the low pass filter on the entrance side (position illustrated in FIG. 12 ) in the model, based on the data for learning, thereby generating the model having the low pass filter on the entrance side in the model.
  • the model generation portion 193 sets the parameters of the template having the low pass filter on the differentiation side in the inputs (between the block B11 and the block B22 in FIG. 12 ), based on the data for learning, thereby generating the model having the low pass filter on the differentiation side in the inputs.
  • the model generation portion 193 selects the model in which an error between the output and the teacher signal is evaluated to be relatively small, among the plurality (for example, two) of generated models.
  • Various types of evaluation methods can be applied when evaluating the magnitude of an error by the model generation portion 193.
  • the model generation portion 193 may select the model in which the average value of the magnitude of errors is minimized. Otherwise, the model generation portion 193 may select the model in which x + 2 ⁇ (x indicates the average of errors, and ⁇ indicates standard deviation of an error) is minimized.
  • the particular site position calculation portion 194 calculates the position of the particular site based on the three-dimensional positional information on the infrared marker acquired by the position-related information acquisition portion 191, by using the model selected by the model generation portion 193, thereby outputting the result thereof.
  • the model generated by the model generation portion 193 may include a model which is not provided with the filter regulating the amount of change in the position of the particular site output by the model.
  • the model generation portion 193 generates the model provided with the filter regulating the amount of change in the position of the particular site output by the model.
  • the position of the particular site output by the model can be prevented from suddenly changing due to an error occurring during the process of calculation performed by using the model or noise mixed into the signal used by the control device 12 for a radiation treatment apparatus. Accordingly, an error between the output of the model and the actual position of the particular site caused by the sudden change can be prevented from increasing. In addition, it is possible to prevent an error occurring when the control device 12 for a radiation treatment apparatus performs controlling beyond the performance of the radiation treatment apparatus 13, based on the sudden change.
  • model generation portion 193 generates the plurality of models in each of which the filter regulating the amount of change in the position of the particular site output by the model is provided at a position different from that in each of the others.
  • the model generation portion 193 selects any one of the generated models.
  • the particular site position calculation portion 194 calculates the position of the particular site by using the model selected by the model generation portion 193, thereby outputting the result thereof.
  • the particular site position calculation portion 194 can calculate the positional information on the particular site by using the model provided with the filter at a more suitable position, thereby being able to output the result thereof. Accordingly, it is possible to further reduce an error between the position of the particular site output by the particular site position calculation portion 194 and the actual position of the particular site.
  • model generation portion 193 sets the parameters of the model template provided with the filter regulating the amount of change in the position of the particular site output by the model, thereby generating the model provided with the filter.
  • the model generation portion 193 can evaluate the output of the model including the influence of the filter and can generate the model having a smaller error between the output and the actual position of the particular site.
  • a program which realizes the entirety or a portion of the function of the control unit 190 may be recorded in a computer readable recording medium, and processing of each component may be performed by causing a computer system to read and execute the program recorded in the recording medium.
  • the aforementioned "computer system” includes OS and hardware such as peripherals.
  • the computer system is considered to include a homepage-provided environment (or homepage displaying environment).
  • the aforementioned "computer readable recording medium” includes a portable medium such as a flexible disk, an magneto-optical disk, ROM, and CD-ROM; and a storage medium such as a hard disk built in the computer system.
  • the computer readable recording medium includes a medium such as a communication cable in a case where a program is transmitted via a network such as the internet, and a communication channel such as a telephone line, dynamically retaining a program for a short period of time.
  • the computer readable recording medium also includes a medium such as a volatile memory in the computer system serving as a server or a client in a case thereof, retaining a program for a certain period of time.
  • the program may be a program which realizes a portion of the above-described function.
  • the program may be a program which can be realized by combining the above-described function with the program which is already recorded in the computer system.
  • the present invention relates to a control device for a radiation irradiation device including a position-related information acquisition portion that acquires position-related information related to a position of a particular site; a model generation portion that generates a model outputting the position of the particular site based on the position-related information; and a particular site position calculation portion that outputs the position of the particular site based on the position-related information acquired by the position-related information acquisition portion, by using the model generated by the model generation portion.
  • the model generated by the model generation portion is provided with a filter regulating an amount of change in the position of the particular site output by the model.
  • control device for a radiation treatment apparatus it is possible to acquire positional information on the particular site with highly improved accuracy.

Claims (4)

  1. Dispositif de commande pour un dispositif de traitement par rayonnement, le dispositif de commande comprenant :
    une partie (191) d'acquisition d'informations relatives à une position pour acquérir des informations relatives à une position relatives à une position d'un site particulier ;
    une partie (193) de génération de modèle pour générer un modèle délivrant en sortie la position du site particulier sur la base des informations relatives à une position ; et
    une partie (194) de calcul de position de site particulier pour délivrer en sortie la position du site particulier sur la base des informations relatives à une position acquises par la partie d'acquisition d'informations relatives à une position, en utilisant le modèle généré par la partie de génération de modèle,
    dans lequel le modèle généré par la partie de génération de modèle est prévu avec un filtre passe-bas régulant une quantité de changement de la position du site particulier délivrée en sortie par le modèle, et
    la partie de génération de modèle est adaptée à définir des paramètres d'un gabarit modèle prévu avec le filtre passe-bas de façon à minimiser une erreur entre une sortie après passage par le filtre passe-bas et un signal maître indiquant la décision correcte de la position du site particulier, afin de générer le modèle prévu avec le filtre passe-bas.
  2. Dispositif de commande pour le dispositif de traitement par rayonnement selon la revendication 1,
    dans lequel la partie (193) de génération de modèle est adaptée à générer une pluralité des modèles dans chacun desquels le filtre est prévu en une position différente de celle dans chacun des autres et sélectionne l'un quelconque des modèles, et
    dans lequel la partie (194) de calcul de position de site particulier est adaptée à délivrer en sortie la position du site particulier sur la base des informations relatives à une position acquises par la partie (191) d'acquisition d'informations relatives à une position, en utilisant le modèle sélectionné par la partie de génération de modèle.
  3. Procédé de commande pour commander un dispositif de traitement par rayonnement par un dispositif de commande, le procédé de commande comprenant :
    une étape de partie d'acquisition d'informations relatives à une position pour acquérir des informations relatives à une position relatives à une position d'un site particulier ;
    une étape de génération de modèle pour générer un modèle délivrant en sortie la position du site particulier sur la base des informations relatives à une position ; et
    une étape de calcul de position de site particulier pour délivrer en sortie la position du site particulier sur la base des informations relatives à une position acquises à l'étape d'acquisition d'informations relatives à une position, en utilisant le modèle généré à l'étape de génération de modèle,
    dans lequel le modèle généré à l'étape de génération de modèle est prévu avec un filtre passe-bas régulant une quantité de changement de la position du site particulier délivrée en sortie par le modèle, et
    à l'étape de génération de modèle, des paramètres d'un gabarit modèle prévu avec le filtre passe-bas sont définis de façon à minimiser une erreur entre une sortie après passage par le filtre passe-bas et un signal maître indiquant la décision correcte de la position du site particulier, afin de générer le modèle prévu avec le filtre passe-bas.
  4. Programme qui fait en sorte qu'un ordinateur incluant un dispositif de commande pour un appareil de traitement par rayonnement exécute :
    une étape de partie d'acquisition d'informations relatives à une position pour acquérir des informations relatives à une position relatives à une position d'un site particulier ; et
    une étape de génération de modèle pour générer un modèle délivrant en sortie la position du site particulier sur la base des informations relatives à une position ; et
    une étape de calcul de position de site particulier pour délivrer en sortie la position du site particulier sur la base des informations relatives à une position acquises à l'étape d'acquisition d'informations relatives à une position, en utilisant le modèle généré à l'étape de génération de modèle,
    dans lequel, à l'étape de génération de modèle, des paramètres d'un gabarit modèle prévu avec un filtre passe-bas sont définis de façon à minimiser une erreur entre une sortie après passage par le filtre passe-bas, le filtre passe-bas régulant une quantité de changement de la position du site particulier délivrée en sortie par le modèle, et un signal maître indiquant la décision correcte de la position du site particulier, et le modèle prévu avec le filtre passe-bas est généré.
EP13896186.7A 2013-10-24 2013-10-24 Dispositif de commande pour dispositif de planification de traitement, procédé de commande, et programme Active EP3061495B1 (fr)

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JP6815586B2 (ja) * 2015-06-02 2021-01-20 東芝エネルギーシステムズ株式会社 医用画像処理装置、および治療システム
WO2019141138A1 (fr) * 2018-01-19 2019-07-25 深圳市奥沃医学新技术发展有限公司 Procédé et dispositif de détection de position, et système de radiothérapie
WO2019210456A1 (fr) 2018-05-02 2019-11-07 Shenzhen United Imaging Healthcare Co., Ltd. Systèmes et procédés de génération de plan de radiothérapie
CN110691551B (zh) 2018-05-02 2023-05-09 上海联影医疗科技股份有限公司 用于放射治疗和成像的放射系统
US10892064B2 (en) 2018-12-05 2021-01-12 Shanghai United Imaging Healthcare Co., Ltd. Multi-leaf collimator

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EP1673146B1 (fr) 2003-09-30 2012-11-14 Koninklijke Philips Electronics N.V. Appareil de suivi de cible pour la planification et l'administration d'une radiotherapie
US8095203B2 (en) * 2004-07-23 2012-01-10 Varian Medical Systems, Inc. Data processing for real-time tracking of a target in radiation therapy
WO2008096285A2 (fr) * 2007-02-07 2008-08-14 Koninklijke Philips Electronics, N.V. Estimation du mouvement dans la planification d'un traitement
WO2009042637A2 (fr) 2007-09-24 2009-04-02 Oregon Health & Science University Localisation non invasive et suivi de tumeurs et autres tissus pour la radiothérapie
JP2010183976A (ja) * 2009-02-10 2010-08-26 Mitsubishi Heavy Ind Ltd 放射線治療装置制御装置および放射線照射方法
US9364687B2 (en) * 2011-01-21 2016-06-14 Headwater Partners Ii Llc Imaging observation timing based on radiation treatment system element delay
US20140107390A1 (en) * 2012-10-12 2014-04-17 Elekta Ab (Publ) Implementation and experimental results of real-time 4d tumor tracking using multi-leaf collimator (mlc), and/or mlc-carriage (mlc-bank), and/or treatment table (couch)

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EP3061495A4 (fr) 2017-01-18
WO2015059805A1 (fr) 2015-04-30
US20160271423A1 (en) 2016-09-22
JP6105743B2 (ja) 2017-04-05
EP3061495A1 (fr) 2016-08-31
US10398913B2 (en) 2019-09-03
JPWO2015059805A1 (ja) 2017-03-09

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