EP2970834A2 - Composition de conservateur naturel à spectre large - Google Patents

Composition de conservateur naturel à spectre large

Info

Publication number
EP2970834A2
EP2970834A2 EP14763192.3A EP14763192A EP2970834A2 EP 2970834 A2 EP2970834 A2 EP 2970834A2 EP 14763192 A EP14763192 A EP 14763192A EP 2970834 A2 EP2970834 A2 EP 2970834A2
Authority
EP
European Patent Office
Prior art keywords
weight
oil
amount
combinations
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14763192.3A
Other languages
German (de)
English (en)
Other versions
EP2970834A4 (fr
Inventor
Shanta M. Modak
Santoshkumar DONGRE
Arnab Kumar GHOSH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University of New York
Original Assignee
Columbia University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University of New York filed Critical Columbia University of New York
Publication of EP2970834A2 publication Critical patent/EP2970834A2/fr
Publication of EP2970834A4 publication Critical patent/EP2970834A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • compositions such as, for example, personal care formulations, preservatives for food and beverage products, disinfectants for food, topical disinfectants, surface disinfectants and oral formulations.
  • the ideal preservative should have broad spectrum antimicrobial activity and the ability to be used in various types of formulations without affecting the function, color or odor of the final product.
  • a preservative composition desirably inactivates bacteria, fungi as well as yeast in both cationic and anionic formulations. Additionally, preservatives should have a low risk of irritation and sensitizing potential. While certain essential oils have antibacterial activity and may be suitable in that regard, most have a distinct odor and are therefore not universally appropriate for use as preservatives in personal care products.
  • Biosecur ® is the first certified organic ingredient for use as a broad- spectrum preservative and disinfectant. Biosecur ® is derived from 100% organic citrus fruit, but does not contain grapefruit. It has been reported that, in tests performed according to U.S. Food and Drag Administration's (FDA's) Good
  • Biosecur ® was found to kill more than 99.999% of common bacteria within 15- to 30-seconds after contact. Furthermore, Biosecur ® is reported to provide broad-spectrum antimicrobial efficacy against various bacteria, fungi and yeast.
  • compositions comprising effective amounts of one or more organic acid, for example but not limited to, fruit acid such as lactic acid, citric acid, benzoic acid and/or its derivatives, and combinations thereof; one or more botanical extract such as Biosecur ® , citrus extract (for example but not limited to, grapefruit seed extract, lemon extract, orange extract and combinations thereof), echinacea extract, portulaca extract, tetrahydi curcuminoids, wasabi extract, honeysuckle extract, myrrh extract and combinations thereof; one or more essential oil or active constituent thereof, for example but not limited to, cinnamon oil, pine oil, thymol, thyme oil, lemongrass oil, lemon oil, basil oil, oregano oil, rosemary oil, farnesol, cedarwood oil, vetiver, patchouli oil and combinations thereof; and solvent, for example but not limited to, alcohol such as benzyl alcohol, phenyl ethanol, ethyl alcohol and combinations thereof, each of which are
  • the composition comprises between about 0.1-1.0% weight/weight (w/w) citrus extract selected from the group consisting of Biosecur ® , grape fruit seed extract, lemon extract, orange extract and combinations thereof; between 0.05-1.0% w/w organic acid, for example but not limited to, fruit acid such as lactic acid, citric acid, benzoic acid and/or its derivatives, and combinations thereof; between 0.05-0.1% w/w essential oil or constituents thereof selected from the group consisting of cinnamon oil, pine oil, thymol, thyme oil, lemongrass oil, lemon oil, basil oil, oregano oil, rosemary oil, farnesol, cedarwood oil, vetiver. patchouli oil and combinations thereof; and between 0.05-1.0% w/w solvent selected from the group consisting of phenyl ethanol, ethanol and
  • compositions described herein include citrus extract, wherein the citrus extract can include Biosecur ® . In certain embodiments, the compositions described herein include citrus extract, wherein the citrus extract does not include Biosecur ® .
  • Ranges specified herein include their recited limits; for example, a range of between 2 and 4 includes 2 and 4.
  • compositions comprising effective antimicrobial amounts of a combination of one or more botanical extract such as citrus extract selected from Biosecur ® , grapefruit seed extract, lemon extract, orange extract and combinations thereof, echinacea extract, portulaca extract, tetrahydrocurcuminoids, wasabi extract, honeysuckle extract, myrrh extract and combinations thereof; organic acid, for example but not limited to, fruit acid such as lactic acid, citric acid, benzoic acid and/or its derivatives, and combinations thereof; one or more essential oil or active constituent thereof and one or more solvent, for example, alcohol such as benzyl alcohol, phenyl ethanol, ethyl alcohol (ethanol) and combinations thereof.
  • botanical extract such as citrus extract selected from Biosecur ® , grapefruit seed extract, lemon extract, orange extract and combinations thereof, echinacea extract, portulaca extract, tetrahydrocurcuminoids, wasabi extract, honeysuckle extract, myrrh extract and combinations thereof
  • organic acid for example
  • a botanical extract for example, a citrus extract
  • a fresh botanical source for example, a citrus fruit
  • the essential oils are selected from the group consisting of cinnamon oil (for example cinnamon bark oil and/or cinnamon leaf oil), thyme oil, cedarwood oil, lemon oil, galangal oil, pine oil, basil oil, oregano oil, rosemary oil, cedarwood oil, patchouli oil, vetiver oil, lemongrass oil and
  • Active constituents of these essential oils include, but are not limited to, cinnamaldehyde, cinnamylacetic ester, cinnamic acid, ethyl cinnamate, methyl chavicol, linalool, beta-caryophyllene, eugenol, thymol, cedrol, cedrene, limonene, d-limonene, geranyl acetate, nerol, geraniol, citral, myrcene, farnesol and combinations thereof.
  • the citrus extract is selected from the group consisting of Biosecur ® , lemon extract, orange extract and citrus bioflavonoids.
  • Biosecur ® may optionally be substituted with a citrus extract, meaning an extract of juice, or pulp, or rind, or a combination thereof, derived from a citrus fruit or fruits such as orange, lemon and lime, (in certain non-limiting embodiments, not grapefruit and in other non-limiting embodiments, optionally grapefruit) which comprises at least 0.1 percent citric acid and at least 0.2 percent (1 mg/ml) ascorbic acid.
  • the citrus extract comprises one or more citrus bioflavonoids.
  • Preservative effect as used herein means “antimicrobial effect.”
  • Antimicrobial effect is static or reduced growth of microbes such as one or more of bacteria (Gram positive and/or Gram negative), protozoa, yeast or fungi.
  • Exemplary microbes which may be inhibited include Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger.
  • the additional components may include components known in the art for an intended use, for example in personal care products, foods, beverages, and as topical or surface disinfectants.
  • the components may comprise one or more of water or other solvent, thickening agent(s), emollient(s), food product, etc., as the case may be.
  • the amount of botanical extract in a composition is between about 0.005 and 5 percent weight/weight ("w/w"), or between about 0.005 and 1 percent w/w, or between about 0.01 and 1 percent w/w, or between about 0.1 and 1.0 percent w/w, or between about 0.05 and 5 percent w/w, or between about 0.05 and 1 percent w/w, or between about 0.1 and 4 percent w/w, or between about 0.15 and 3 percent w/w, or between about 0.2 and 2 percent w/w, or between about 0.3 and 1 percent w/w, or between about 0.5 and 1 percent w/w, or between about 0.2 and 1 percent w/w.
  • w/w percent weight/weight
  • the botanical extract is selected from the group consisting of Biosecur ® , citrus extract, echinacea extract, portulaca extract, tetrahydrocurcuminoids, wasabi extract, honeysuckle extract, myrrh extract and combinations thereof.
  • “About” as used herein means plus or minus 10 percent of the recited value.
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising one or more botanical extract at a concentration between about 1 and about 90 % w/w, or between about 5 and about 80 % w/w, or between about 5 and about 70 % w/w, or between about 20 and about 70% w/w, or between about 10 and about 50 % w/w, or between about 20 and about 40 % w/w.
  • the botanical extract is present in the stock at a concentration of between about 40 and about 80 % w/w, or between about 5 and about 50 % w/w, or between about 5 and about 30 % w/w.
  • the amount of organic acid in a composition is between about 0.0001 and about 1 percent w/w, or between about 0.0001 and about 0.1 percent w/w, or between about 0.0001 and about 0.2 percent w/w, or between about 0.005 and 3 percent w/w, or between about 0.01 and 2 percent w/w, or between about 0.01 and 0.2 percent w/w, or between about 0.05 and 1 percent w/w, or between about 0.1 and 0.5 percent w/w, or between about 0.2 and 0.5 percent w/w.
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising organic acid at a concentration between about 1 and about 90 % w/w, or between about 5 and about 80 % w/w, or between about 20 and about 70% w/w, or between about 10 and about 50 % w/w, or between about 20 and about 40 % w/w.
  • the organic acid is present in the stock at a concentration of between about 0.005 and about 5 % w/w, or between about 0.05 and about 2 % w/w, or between about 0.01 and about 1 % w/w.
  • the organic acid is present in the stock at a concentration of between about 40 and about 80 % w/w, or between about 5 and about 30 % w/w, or between about 2 and about 30% w/w, or between about 2 and about 20% w/w, or between about 0.01 and about 20 % w/w,.
  • compositions of the present application comprise an essential oil or active constituent thereof selected from the group consisting of cinnamon oil (for example cinnamon bark oil and/or cinnamon leaf oil), cinnamaldehyde, orange oil, rosemary oil, cedar wood oil, sandal wood oil, patchouli oil, vetiver oil, lemongrass oil, limonene, thymol, thyme oil, ylang ylang oil, lemon oil, fennel oil, fenugreek oil, coriander leaf oil, cedrol, cedrene, citral, pine oil, basil oil, oregano oil, farnesol and combinations thereof.
  • cinnamon oil for example cinnamon bark oil and/or cinnamon leaf oil
  • cinnamon oil for example cinnamon bark oil and/or cinnamon leaf oil
  • cinnamon oil for example cinnamon bark oil and/or cinnamon leaf oil
  • cinnamon oil for example cinnamon bark oil and/or cinnamon leaf oil
  • cinnamon oil for example cinnamon bark oil and/or cinnamon leaf oil
  • cinnamon oil for example cinnamon bark oil and/or cinnamon leaf oil
  • cinnamon oil for example cinnamon bark
  • the amount of essential oil, active constituent thereof, in a composition is between about 0.00005 and about 1 percent w/w, or between about 0.0001 and about 1 percent w/w, or between about 0.0001 and about 0.5 percent w/w, or between about 0.005 and 2 percent w/w, or between about 0.01 and 1 percent w/w, or between about 0.02 and 0.5 percent w/w, or between about 0.03 and 0.1 percent w/w, or between about 0.05 and 0.1 percent w/w.
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising one or more essential oil and/or active constituent thereof at a concentration between about 1 and about 90 % w/w, or between about 5 and about 80 % w/w, or between about 20 and about 70% w/w, or between about 10 and about 50 % w/w, or between about 20 and about 40 % w/w.
  • the essential oil and/or active constituent thereof is present in the stock at a concentration of between about 0.005 and about 20 % w/w, or between about 0.01 and about 10 % w/w, or between about 0.1 and about 5 % w/w.
  • the essential oil and/or active constituent thereof is present in the stock at a concentration of between about 0.01 and about 10 % w/w, or between about 1 and about 10 % w/w.
  • the compositions of the present application comprise a solvent, such as an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethyl alcohol and combinations thereof.
  • a solvent such as an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethyl alcohol and combinations thereof.
  • the amount of solvent in a composition is between about 0.001 and 4 percent w/w, or between about 0.005 and 3 percent w/w, or between about 0.01 and 2 percent w/w, or between about 0.01 and 1 percent w/w, or between about 0.05 and 1 percent w/w, or between about 0.1 and 0.5 percent w/w.
  • the amount of solvent in a composition is between about 0.001 and 10 percent w/w, or between about 0.005 and 8 percent w/w, or between about 0.01 and 5 percent w/w. In specific non-limiting embodiments, the amount of solvent in a composition is between about 0.01 and 6 percent w/w, or between about 0.01 and 1 percent w/w.
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising a solvent such as an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethyl alcohol and combinations thereof, at a concentration between about 1 and about 90 % w/w, or between about 5 and about 80 % w/w, or between about 20 and about 70% w/w, or between about 10 and about 50 % w/w, or between about 20 and about 40 % w/w.
  • a solvent such as an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethyl alcohol and combinations thereof, at a concentration between about 1 and about 90 % w/w, or between about 5 and about 80 % w/w, or between about 20 and about 70% w/w, or between about 10 and about 50 % w/w, or between about 20 and about 40 % w/w.
  • the solvent is present in the stock at a
  • concentration of between about 5 and about 45 % w/w, or between about 30 and about 80 % w/w, or between about 20 and about 80 % w/w, or between about 5 and about 80 % w/w.
  • compositions disclosed herein comprise benzoic acid at a concentration between about 0.01 and about 0.2 % w/w; Biosecur ® at a concentration between about 0.05 and about 1 % w/w; thyme oil, thymol, or combinations thereof, at a concentration between about 0.01 and about 1 % w/w; and an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and combinations thereof, at a concentration between about 0.01 and about 1 % w/w.
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising benzoic acid at a concentration between about 2 and about 20 % w/w; Biosecur ® at a concentration between about 20 and about 70 % w/w; thyme oil, thymol, or combinations thereof, at a concentration between about 1 and about 10 % w/w; and an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and combinations thereof, at a concentration between about 5 and about 45 %w/w.
  • compositions disclosed herein comprise benzoic acid at a concentration between about 0.0001 and about 0.1 % w/w;
  • Biosecur at a concentration between about 0.005 and about 1 % w/w; one or more essential oil or active constituent thereof, selected from the group consisting of cinnamon oil, thyme oil, thymol, cinnam ldehyde and combinations thereof, at a concentration between about 0.0001 and about 0.5 % w/w; and an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and combinations thereof, at a concentration between about 0.01 and about 1 %w/w.
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising benzoic acid at a concentration between about 0.01 and about 1 % w/w; Biosecur ® at a concentration between about 5 and about 30 % w/w; one or more essential oil or active constituent thereof, selected from the group consisting of cinnamon oil, thyme oil, thymol, cinnamaldehyde and combinations thereof, at a concentration between about 0.01 and about 10 % w/w; and an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and combinations thereof, at a concentration between about 20 and about 80 %w/w.
  • compositions disclosed herein comprise benzoic acid at a concentration between about 0.01 and about 0.2 % w/w; one or more botanical extract selected from the group consisting of portulaca extract,
  • tetrahydrocurcumanoids and combinations thereof at a concentration between about 0.01 and about 1 % w/w; thyme oil, thymol, or combinations thereof, at a
  • an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising benzoic acid at a concentration between about 2 and about 20 % w/w; one or more botanical extract selected from the group consisting of portulaca extract, tetrahydrocurcumanoids and combinations thereof, at a concentration between about 5 and about 50 % w/w; thyme oil, thymol, or combinations thereof, at a concentration between about 1 and about 10 % w/w; and an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and combinations thereof, at a concentration between about 30 and about 80 %w/w.
  • compositions disclosed herein comprise benzoic acid at a concentration between about 0.0001 and about 0.2 % w/w; one or more botanical extract selected from the group consisting of Biosecur ® , citrus extract, portulaca extract, Tetrahydocurcumanoids (THC) and derivatives thereof, echinacea extract, and combinations thereof, in an amount between about 0.005 and 1 % w/w; an essential oil, or active constituent thereof, selected from the group consisting cinnamon oil, lemon oil, thyme oil, galangal oil, thymol, cinnamaldehyde and combinations thereof, in an amount between about 0.0001 and 1 % w/w: and an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and combinations thereof, at a concentration between about 0.01 and about 1 %w/w.
  • one or more botanical extract selected from the group consisting of Biosecur ® , citrus extract, portulaca extract, Tetrahy
  • compositions disclosed herein comprise stock solutions that can be diluted for use comprising benzoic acid at a concentration between about 0.01 and about 20 % w/w; one or more botanical extract selected from the group consisting of Biosecur ® , citrus extract, portulaca extract,
  • Tetrahydocurcumanoids THC and derivatives thereof, echinacea extract, and combinations thereof, in an amount between about 5 and 70 % w/w; an essential oil, or active constituent thereof, selected from the group consisting cinnamon oil, lemon oil, thyme oil, galangal oil, thymol, cinnamaldehyde and combinations thereof, in an amount between about 0.01 and 10 % w/w; and an alcohol solvent selected from the group consisting of benzyl alcohol, phenyl ethanol, ethanol and combinations thereof, at a concentration between about 5 and about 80 % w/w.
  • THC Tetrahydocurcumanoids
  • compositions disclosed herein comprise between about 0.1-1.0% w/w citrus extract selected from the group consisting of Biosecur ® , grapefruit seed extract, lemon extract, orange extract and combinations thereof; between 0.05-1.0% w/w organic acid, for example but not limited to, fruit acid such as lactic acid, citric acid, benzoic acid and/or its derivatives, and
  • w/w essential oil or constituents thereof selected from the group consisting of cinnamon oil, pine oil, thymol, thyme oil, lemongrass oil, lemon oil, basil oil, oregano oil, rosemary oil, farnesol, cedarwood oil, vetiver. patchouli oil and combinations thereof; and between 0.05-1.0% w/w solvent selected from the group consisting of phenyl ethanol, ethanol and
  • compositions of the present application may further comprise an agent that masks the odor of the composition or otherwise enhances the olfactory appeal of the composition.
  • the making agent is an essential oil.
  • the masking agent is in an amount between about 0.01 and 1, or between about 0.05 and 1 percent weight/weight.
  • the composition does not further comprise antimicrobial effective amounts of any of the following antimicrobial agents: quaternary ammonium compounds such as but not limited to benzalkonium chloride, benzethenium chloride, or cetylpyridinfum chloride, biguanides such as chlorhexidine (e.g. chlorhexidine free base, chlorhexidine gluconate or chlorhexidine acetate) or polyhexamethylenebiguanide, chlorinated phenols, triclosan,
  • quaternary ammonium compounds such as but not limited to benzalkonium chloride, benzethenium chloride, or cetylpyridinfum chloride
  • biguanides such as chlorhexidine (e.g. chlorhexidine free base, chlorhexidine gluconate or chlorhexidine acetate) or polyhexamethylenebiguanide, chlorinated phenols, triclosan,
  • chlorhexidine or chlorhexidine salt phenoxyethanol, povidone iodine, aliphatic alcohol, or parachlorometaxylenol.
  • composition does further comprise antimicrobial effective amounts of one or more of the following:
  • antimicrobial agents quaternary ammonium compounds such as but not limited to benzalkonium chloride, benzethenium chloride, or cetylpyridinium chloride, biguanides such as chlorhexidine (e.g. chlorhexidine free base, chlorhexidine gluconate or chlorhexidine acetate) or polyhexamethylenebiguanide, chlorinated phenols, triclosan, chlorhexidine or chlorhexidine salt, phenoxyethanol, povidone iodine, aliphatic alcohol, or parachlorometaxylenol.
  • biguanides such as chlorhexidine (e.g. chlorhexidine free base, chlorhexidine gluconate or chlorhexidine acetate) or polyhexamethylenebiguanide, chlorinated phenols, triclosan, chlorhexidine or chlorhexidine salt, phenoxyethanol, povidone iodine, aliphatic alcohol, or parachlorometaxyl
  • the composition does not contain any fruit acid.
  • compositions described herein include citrus extract, wherein the citrus extract can include Biosecur ® .
  • citrus extract can include Biosecur ® .
  • compositions described herein include citrus extract, wherein the citrus extract does not include Biosecur .
  • the composition does not contain any lauroyl arginate, ethyl lauroyl arginate, glycerol monolaurate, glyceryl laurate and/or propylene glycol monolaurate.
  • the composition comprises lauroyl arginate, ethyl lauroyl arginate, glycerol monolaurate, glyceryl laurate and/or propylene glycol monolaurate at a concentration below 0.000005 weight percent.
  • the composition does not comprise benzyl alcohol.
  • the stock preservative can be incorporated into the final product at a use level of between about 0.7 and 1.2% weight/weight (w/w) (such that the preservative constitutes between about 0.7 and 1.2 % (w/w) of the final product), or at a use level of between about 0.1 and 0.5 % w/w, or at a use level of between about 0.1 and 0.5% w/w, or at a use level of between about 0.7 and 1% w/w, or at a use level of between about 1.0 and 2.0% w/w, or at a use level of about 1.5% w/w.
  • the stock preservative can be incorporated into the final product at a use level of about 0.2% w/w.
  • %w/w stock refers to the percent amount, weight to weight, in a stock solution
  • w/w final refers to the percent amount, weight to weight, in the final product.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor maskmg agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition further comprises an odor masking agent.
  • the odor masking agent is selected from the group consisting of patchouli oil, vetiver oil, sandal wood oil and sandal wood oil related fragrances.
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components: Ingredients % w/w stock
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • composition comprises the following components:
  • the composition comprises the following components:
  • the composition comprises the following components:
  • compositions that may be comprised in personal care products to impart antimicrobial activity and accordingly act as preservatives.
  • the composition is a stock solution comprising the recited active agents and a suitable solvent.
  • suitable solvents include water, ethanol, glycerin, octoxyglycerin, and mixtures thereof.
  • Personal care products comprising the above ingredients include, but are not limited to, creams such as but not limited to hand cream, lotions and splashes, hair care products, makeup (for example but not limited to foundation, powder, lipstick and eye makeup such as shadow, liner and mascara) and other cosmetic products, gels, tonics, shampoos, soaps (e.g., liquid or bar soap), and wipe
  • formulations may be applied to humans or non-human animals (for example, for veterinary or agricultural purposes, for example, as a veterinary cream, veterinary splash, etc.).
  • the preservative compositions of the present application are incorporated into a base comprising the following components:
  • the preservative compositions of the present application are incorporated into a base comprising the following components:
  • composition is a soap comprising the following components:
  • Polyquaternium-10 (U-care polymer JR-30M) 0.1-0.3
  • Grape fruit seed extract 0.0-1.0
  • the composition is a soap comprising the following specific components: Specific formulation -1
  • Lactic acid 0.5 Aloe vera gel (IX) 2.0
  • a method for producing a preservative or antimicrobial effect i.e., inhibiting the growth of microbes
  • a preservative formulation as set forth herein into the product.
  • Microbes, the growth of which are inhibited include but are not limited to one or more of Aspergillus niger, Candida albicans, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa,
  • Enterococcus Streptococcus species and Salmonella species (e.g. typhimurium, enteritidis) and Listeria monocytogenes.
  • Food and beverage products comprising the above ingredients include, but are not limited to, juices such as apple, tomato, orange, pineapple, cranberry and grapefruit juice (and mixtures thereof), fruit cocktails, soft drinks, sodas, punches, canned fruits and vegetables, related products such as fruit cocktail and apple sauce, salad dressings, condiments such as catsup, and baby foods.
  • the composition is a food preservative comprising the following components:
  • the composition is a food preservative comprising the following components:
  • Cinnamon bark oil 0,01528
  • the composition is a food preservative comprising the following components:
  • the composition is a food preservative comprising the following components:
  • compositions that may be comprised in disinfectant compositions that may be used to reduce the number and/or growth of microbes on food products such as but not limited to vegetables, fruit, meat, poultry and fish.
  • the disinfectant may be used by one or more of the original food producer or a food processor or the consumer.
  • the food item may be washed, dipped, or soaked (for example, for between about 30 seconds and 1 hour or between about 30 seconds and 5 minutes) in the disinfectant composition, optionally followed by rinsing with water prior to consumption.
  • the composition is a stock solution comprising the recited active agents and a suitable solvent.
  • suitable solvents include water, ethanol, glycerin, octoxyglycerin, and mixtures thereof.
  • the stock disinfectant can be incorporated into the final product at a use level of between about 0.01 and 10 percent w/w.
  • Microbes Disclosed herein is a method of reducing the number and/or growth of microbes in or on a food product comprising exposing the food product to a disinfectant composition as set forth herein.
  • Microbes, the numbers and/or growth of which are reduced include but are not limited to one or more of Aspergillus niger, Candida albicans, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Enterococcus, Streptococcus species, Salmonella species (e.g. typhimurium, enteritidis) and Listeria monocytogenes.
  • compositions that may be comprised in disinfectant compositions that may be used to topically to reduce the number and/or growth of microbes on the skin of a human or non-human animal.
  • the disinfectant may be a wash solution, a lotion, a cream, or a splash and/or may be comprised in a wipe.
  • the disinfectant composition comprises the recited active agents and a suitable solvent.
  • suitable solvents include water, ethanol, glycerin, octoxyglycerin, and mixtures thereof.
  • Disclosed herein is a method of reducing the number and/or growth of microbes on the skin of a subject comprising applying to the skin a topical
  • Microbes include but are not limited to one or more of Staphylococcus aureus (including methicillin resistant Staphylococcus aureus), Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans,
  • compositions that may be comprised in disinfectant compositions that may be used to topically to reduce the number and/or growth of microbes on inanimate surfaces, for use in disinfecting, for example and not by way of limitation, hard surfaces such as floors, countertops, sinks, toilets, shower stalls, tables, furniture, car interiors, baby furniture, etc. as well as soft surfaces but non-absorbent surfaces such as leather or vinyl.
  • the disinfectant composition comprises the recited active agents and a suitable solvent.
  • suitable solvents include water, ethanol, glycerin, octoxyglycerin, and mixtures thereof.
  • Microbes, the numbers and/or growth of which are reduced include but are not limited to one or more of Staphylococcus aureus
  • Staphylococcus aureus including methicillin resistant Staphylococcus aureus), Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus niger and Listeria monocytogenes.
  • the composition is a surface disinfectant comprising the following components:
  • the composition is a surface disinfectant comprising the following components:
  • the compositions described herein are oral care compositions for use in reducing the number and/or growth of microbes in the mouth of a subject. Also provided is a method of reducing the number and/or growth of microbes in the mouth of a subject comprising applying the oral care composition to an inside surface of the mouth of the subject.
  • a stock oral care composition can be incorporated into the final product at a use level of between about 0.7 and 1.2% weight/weight (w/w) (such that the preservative constitutes between about 0.7 and 1.2 % (w/w) of the final product), or at a use level of between about 1.0 and 2.0% w/w, at a use level of about 1.5% w/w.
  • the composition is an oral rinse comprising the following components:
  • the composition is an oral rinse comprising the following components:
  • compositions may contain additional components known in the art for use in personal care compositions.
  • the composition does not contain a petroleum- derived component.
  • the composition may comprise a polyethylene oxide (Polyox) hydrogel polymer which, without being bound to any particular theory, can help the skin retain moisture.
  • the composition may comprise an anti-irritant component, for example a zinc salt, such as zinc gluconate, alpha bisabolol, aloe gel/leaf juice, and combinations thereof.
  • zinc salts that may be used include zinc acetate, zinc butyrate, zinc citrate, zinc glycerate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc propionate, zinc salicylate, zinc tartrate, zinc undecylenate, and combinations thereof.
  • a composition disclosed herein may further comprise a thickening and/or gelling agent such as stearyl alcohol, cationic hydroxy ethyl cellulose (Ucare; JR30), hydroxy propyl methyl cellulose, hydroxy propyl cellulose (Klucei), chitosan pyrrolidone carboxylate (Kytamer), behenyl alcohol, zinc stearate, emulsifying waxes, including but not limited to Incroquat and Polawax, an addition polymer of acrylic acid, a resin such as Carbopol® ETD 2020, guar gum, acacia, acrylates/steareth-20 methacrylate copolymer, agar, algin, alginic acid, ammonium acrylate co-polymers, ammonium alginate, ammonium chloride, ammonium sulfate, amylopectin, attapulgite, bentonite, C9-15 alcohols, calcium a thicken
  • Gelling agents used in vehicles may e natural gelling agents such as natural gums, starches, pectins, agar and gelatin, and may be based on polysaccharides or proteins Examples include but are not limited to guar gum, xanthum gum, alginic acid (E400), sodium alginate (E401), potassium alginate (E402), ammonium alginate (E403), calcium alginate (E404, - polysaccharides from brown algae), agar (E406, a polysaccharide obtained from red seaweeds), carrageenan (E407, a polysaccharide obtained from red seaweeds), locust bean gum (E410, a natural gum from the seeds of the Carob tree), pectin (E440, a polysaccharide obtained from apple or citrus-fruit), and gelatin (E441, made by partial hydrolysis of animal collagen).
  • guar gum alginic acid
  • E401 sodium alginate
  • potassium alginate E40
  • a composition as disclosed herein may optionally further comprise a surfactant.
  • the surfactant may be an anionic surfactant, a cationic surfactant, an ampholytic surfactant, or a nonionic surfactant.
  • Non-limiting examples of surfactants include polyethoxylates, fatty alcohols (e.g., ceteth-20 (a cetyl ether of polyethylene oxide having an average of about 20 ethylene oxide units) and other "BRIJ”TM nonionic surfactants available from ICI Americas, Inc. (Wilmington, DE)), cocamidopropyl betaine, alkyl phenols, fatty acid esters of sorbitol, sorbitan, or polyoxyethylene sorbitan.
  • Suitable anionic surfactants include ammonium lauryl sulfate and lauryl ether sulfosuccinate.
  • a composition as disclosed herein may optionally further comprise a silicone polymer, for example one or more than one polydimethylsiloxane polymer (Dow Corning 225 Silicone Fluid), dimethiconol fluid in dimethicone (Dow Corning 1403 Silicone Fluid), cyclomethicone and dimethicone copoiyl (Dow Corning 3225C Silicone Fluid), silicone glycol (BASF 1066 DCG polyol), and combinations thereof.
  • a silicone polymer for example one or more than one polydimethylsiloxane polymer (Dow Corning 225 Silicone Fluid), dimethiconol fluid in dimethicone (Dow Corning 1403 Silicone Fluid), cyclomethicone and dimethicone copoiyl (Dow Corning 3225C Silicone Fluid), silicone glycol (BASF 1066 DCG polyol), and combinations thereof.
  • a composition as disclosed herein may optionally further comprise one or more additives such as dyes, fragrances, pH adjusters, including basic pH adjusters such as ammonia, mono-, di- and tri- alkyl amines, mono-, di- and tri-alkanolamines, alkali metal and alkaline earth metal hydroxides (e.g., ammonia, sodium hydroxide, potassium hydroxide, lithium hydroxide, monoethanolamine, triethylamine, isopropyl amine, dietlianolamine and triethanolamine); acid pH adjusters such as mineral acids, fruit acids and polycarboxylic acids; vitamins such as vitamin A, vitamin E and vitamin C; polyamino acids and salts, such as ethylenediamine tetraacidic acid (EDTA), preservatives such as Germall plus and DMD hydantoin, and sunscreens such as aminobenzoic acid, 3,4 benzoic acid, arobenzone, cinoxate, diioxybenzone, homosalate,
  • the composition may contain a cationic emulsifer selected from the group consisting of incroquat compounds such as (but not limited to) behenyltrimonium methosulfate in ceteary] alcohol (e.g. , incroquat behenyl TMS and incroquat behenyl TMS 50 (Croda Inc., Edison, N.J.)),
  • a cationic emulsifer selected from the group consisting of incroquat compounds such as (but not limited to) behenyltrimonium methosulfate in ceteary] alcohol (e.g. , incroquat behenyl TMS and incroquat behenyl TMS 50 (Croda Inc., Edison, N.J.)),
  • behenalkonium chloride and cetyl alcohol e.g., incroquat B-65 (Croda Inc., Edison, N.J.)), behenamido propyl ethyl dimonium ethosulfate and stearyl alcohol (Incroquat BES-35 S (Croda Inc., Edison, NJ.)), steralkomum chloride and cetearyl alcohol and PEG-40 Castor oil (e.g. , Incroquat CR concentrate (Croda Inc., Edison, N. J.)), Incroquat CTC-30 (Croda Inc., Edison, NJ.), Incroquat DBM-90 (Croda Inc.
  • VARISOFT® TA 100 (Essen-Degussa, Germany)
  • palmitamidopropyltrimonium chloride e.g., VARISOFT® PATC (Essen-Degussa, Germany)
  • cetearyl alcohol and palmitamidopropyltrimonium chloride (e.g., TEGO® Care CE 40).
  • the microbe is a bacterium or yeast or fungus, for example, but not limited to, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and
  • the personal care formulation is an anionic formulation; in others, it is a cationic formulation.
  • growth is inhibited by at least about 10 percent or at least about 20 percent or at least about 30 percent or at least about 40 percent or at least about 50 percent.
  • the inhibition occurs over a period of up to about 3 months, or up to about 6 months, or up to about 12 months, or up to about 18 months, or up to about 24 months, or up to about 30 months.
  • 5- EXAMPLE 1 Efficacy of portulaca extract, benzoic acid, essential oils and alcohol against various pathogens
  • the formulations used in this study included portulaca extract combined with benzoic acid, essential oils and alcohol incorporated into an emulsion.
  • Methods The following method of testing for antimicrobial activity was used. 25g of an emulsion containing 1-1.2% of a preservative composition was prepared. 0.9 gm aliquots of preservative containing emulsion were dispensed into several culture tubes. Culture tubes were divided into various groups and inoculated with 0.1 ml of the test organism ⁇ Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans (10 cfu/ml) or Aspergillus niger (10 cfu/m )). After mixing, the tubes were incubated for 48 hours for S. aureus and P. aeruginosa and for 7 days for either C.
  • Lemongrass oil 0.05 0.03-0.1
  • Lemongrass oil 0.05 0.03-0.1
  • compositions IB and 2B which contain benzoic acid, was equal to or greater than compositions 1 and 2, respectively, which do not contain benzoic acid.
  • the effect of the compositions comprising benzoic acid was significantly greater when tested against C. albicans and A. niger than the groups without benzoic acid.
  • the testing method used in this study is based on the guidelines issued by the Cosmetics, Toiletries, and Fragrance Association, Inc. (CTFA, 2001). 1.0 % of preservative was added to 25 gms of the base. 0.9 gm aliquots were dispensed into culture tubes. The culture tubes were divided into groups and inoculated with 0.1 ml of the test organism (S. aureus and C. albicans (107cfu/ml), and A niger (107 cfu/ml)). After mixing, the tubes were incubated for 48 hours for S. aureus and C. albicans, and 7 days for A.niger.
  • CFA Cosmetics, Toiletries, and Fragrance Association, Inc.
  • the cultures were then diluted serially with Drug neutralizing fluid (DNF), and 0.5 ml aliquots were plated on TSA and incubated for 24-48 hours (S, aureus and C. albicans were incubated at 37°C, and A.niger at 30°C).
  • DNF Drug neutralizing fluid
  • the emulsion base without the preservatives was inoculated with each organism and was processed similarly. The loglO reduction in colony counts of the test group from the colony counts of control group was determined.
  • control base to which the preservative compositions were added comprised the following:
  • Test organism S. aureus
  • benzoic acid exhibits synergistic activity when combined with citrus extracts and phenyl ethanol.
  • a combination of benzoic acid, citrus extract, phenyl ethanol and essential oils further enhances the activity.
  • Benzoic acid also shows enhanced activity when combined with citrus extract, essential oil and ethanol.
  • Test organism A, niger
  • Test organism A, niger
  • Lemon extract 0.5% + Lactic acid 0.1 % + thymol 0.05% 0.8
  • Alcohol ethanol, phenyl ethanol 23.52 5.0-45.0 and/or benzyl alcohol
  • Alcohol ethanol, phenyl ethanol 71.52 30.0-80.0 and/or benzyl alcohol
  • Apple juice containing 0.1 -0.2 % of FP2 preservative were prepared.
  • A. niger is shown in Table 6.
  • the following method of testing for antimicrobial activity was used. 25g of an emulsion containing 1-1.2% of a preservative composition was prepared. 0.9 gm aliquots of preservative containing emulsion were dispensed into several culture tubes. Culture tubes were divided into various groups and inoculated with 0.1 ml of the test organism Aspergillus niger (10 7 cfu/ml). After mixing, the tubes were incubated for 7 days. The cultures were then diluted serially with Drug Neutralizing Fluid (DNF) and 0.5 ml aliquots were plated on TSA and incubated for 24-48 hours at 30°C. In the control group, the emulsion base without preservative was inoculated with each organism and processed similarly. The loglO reduction in colony counts of the test group from the colony counts of control group was determined.
  • DNF Drug Neutralizing Fluid

Abstract

L'invention concerne des combinaisons d'acide organique, d'extraits botaniques, d'huiles essentielles et d'alcool tel que l'alcool benzylique, le phényl éthanol, l'alcool éthylique et leurs combinaisons, en vue d'une utilisation dans des compositions telles que, par exemple, des formulations de soin personnel, des conservateurs pour des produits d'aliment et de boisson, des désinfectants pour des aliments, des désinfectants topiques, des désinfectants de surface et des formulations orales.
EP14763192.3A 2013-03-15 2014-03-14 Composition de conservateur naturel à spectre large Withdrawn EP2970834A4 (fr)

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US20170348550A1 (en) * 2014-12-26 2017-12-07 Colgate-Palmolive Company Oral Care Compositions and Methods of Use
CN113632790A (zh) 2015-08-18 2021-11-12 高露洁-棕榄公司 基于有机酸的防腐剂体系
CN112807237B (zh) * 2019-11-18 2022-07-12 中山中研化妆品有限公司 一种含有天然抑菌剂的化妆品
CN115551470A (zh) * 2020-04-23 2022-12-30 奥麒英国生物灭杀剂有限公司 含有亚烷基二醇酯的协同防腐剂/个人护理组合物
TR202020358A1 (tr) * 2020-12-12 2022-06-21 Naz Biyoteknoloji Anonim Sirketi Keki̇k tentürlü sprey kompozi̇syonu ve koruyucu maske
EP4088578A1 (fr) * 2021-05-12 2022-11-16 SeedForward GmbH Composition et son utilisation comme répulsif destiné au traitement de protection des semences contre les oiseaux

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US7879365B2 (en) * 2002-02-07 2011-02-01 The Trustees Of Columbia University In The City Of New York Zinc salt compositions for the prevention of dermal and mucosal irritation
WO2007070795A2 (fr) * 2005-12-12 2007-06-21 The Trustees Of Columbia University In The City Of New York Systeme de conservation non traditionnel a large spectre
US20080260708A1 (en) * 2007-04-19 2008-10-23 Hall Mickey A Methods and related systems and formulations to normalize and improve human body chemistry and healing ability
US20090028751A1 (en) * 2007-07-23 2009-01-29 Glenn Robbins Anti-microbial time card
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