EP2968104A1 - Associations d'alkylamidothiazoles et de cyclodextrines - Google Patents

Associations d'alkylamidothiazoles et de cyclodextrines

Info

Publication number
EP2968104A1
EP2968104A1 EP14717675.4A EP14717675A EP2968104A1 EP 2968104 A1 EP2968104 A1 EP 2968104A1 EP 14717675 A EP14717675 A EP 14717675A EP 2968104 A1 EP2968104 A1 EP 2968104A1
Authority
EP
European Patent Office
Prior art keywords
branched
linear
alkyl
dihydroxyphenyl
thiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14717675.4A
Other languages
German (de)
English (en)
Inventor
Cathrin Scherner
Michael WÖHRMANN
Ludger Kolbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP2968104A1 publication Critical patent/EP2968104A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • Melanocytes contain as characteristic cell organelles melanosomes, in which the melanin is formed. Among other things, upon excitation by UV radiation melanin is increasingly formed. This is transported via the living layers of the epidermis (keratinocytes) ultimately in the horny layer (corneocytes) and causes a more or less pronounced brownish to brown-black skin color.
  • hexadecene-1 16-dicarboxylic acid, kojic acid and derivatives, arbutin, ascorbic acid and derivatives, flavonoids, ellagic acid and derivatives, tranexamic acid and various resorcinol derivatives, e.g. 4-n-butylresorcinol, 4-n-hexylresorcinol and 4- (1-phenylethyl) benzene-1, 3-diol.
  • R 2 H, -Ci-C 24 -alkyl (linear and branched), -Ci-C 24 -alkenyl (linear and branched), -CrC 8 - cycloalkyl, -Ci-C 24 -hydroxyalkyl (linear and branched), -Ci-C 24 -alkylaryl (linear and branched), -Ci-C 24 -alkyl heteroaryl (linear and branched),
  • the said thiazoles can be present both as free base and as salt: e.g. as fluoride, chloride, bromide, iodide, sulfate, carbonate, ascorbate, acetate or phosphate.
  • salt e.g. as fluoride, chloride, bromide, iodide, sulfate, carbonate, ascorbate, acetate or phosphate.
  • halogen salts e.g. Chloride and bromide.
  • Alkylamidothiazole in combination with cyclodextrins invention have improved release.
  • the measuring device consists of the donor chamber, in which the test medium (product) is located, and the acceptor chamber, in which the receptor liquid is located. Both chambers are separated by a permeable membrane. It is a commercial filter membrane made of nitrocellulose with a pore size of 0.025 ⁇ (Millipore VSWP04700). For the kinetic determination of the release, samples are taken from the acceptor chamber at fixed intervals. The from the product into the
  • preparations contain 0.000001 to 10% by weight, in particular 0.0001 to 3% by weight, very particularly 0.001 to 1% by weight, of one or more of the alkylamidothiazoles used according to the invention, based on the total weight of the preparation
  • Cosmetic and dermatological preparations according to the invention can be present in various forms. So they can e.g. a solution, an anhydrous preparation, an emulsion or microemulsion of the water-in-oil (W / O) type or of the oil-in-water (O / W) type, a multiple emulsion, for example of the water-in-oil type in water (W / O / W), a gel, a solid stick, an ointment or even an aerosol.
  • a solution an anhydrous preparation, an emulsion or microemulsion of the water-in-oil (W / O) type or of the oil-in-water (O / W) type, a multiple emulsion, for example of the water-in-oil type in water (W / O / W), a gel, a solid stick, an ointment or even an aerosol.
  • the cosmetic and dermatological preparations according to the invention may contain cosmetic adjuvants such as are conventionally used in such preparations
  • cosmetic adjuvants such as are conventionally used in such preparations
  • preservatives bactericides, perfumes, foaming inhibitors, dyes, pigments that have a coloring effect, thickeners, surfactants, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other conventional ingredients
  • a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.
  • Oils such as triglycerides of capric or caprylic acid, further natural oils such as e.g. Castor oil;
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms.
  • Gels according to the invention usually contain low C number alcohols, e.g. Ethanol, Propyleglycol, and water or an above-mentioned oil in the presence of a thickening agent, the preferred oily-alcoholic gels, preferably silica or an aluminum silicate, in aqueous-alcoholic or alcoholic gels
  • Polyacrylate is.
  • Suitable propellants for preparations which can be sprayed from aerosol containers according to the invention are the customary known highly volatile, liquefied propellants, for example hydrocarbons (propane, butane, isobutane), which can be used alone or mixed with one another. Also, compressed air is advantageous to use.
  • compositions according to the invention can also advantageously contain substances which absorb UV radiation in the UVB range, the total amount of the filter substances being, for example, from 0.1% by weight to 30% by weight, preferably from 0.5 to 10% by weight, in particular 1.0 to 6.0% by weight, based on the total weight of the preparations, of providing cosmetic preparations which protect the hair or the skin from the entire range of ultraviolet radiation. They can also serve as a sunscreen for hair or skin.
  • preparations according to the invention may furthermore advantageously contain substances which serve for preserving, the total amount of the preservatives eg being from 0.001% by weight to 30% by weight, preferably from 0.05 to 10% by weight, in particular from 0.1 to 5, 0% by weight, based on the total weight of the preparations, in order to provide cosmetic preparations.
  • the lecithin was weighed into three round bottom flasks and then dissolved with a little ethanol. The solvent was then removed on a rotary evaporator at a slightly elevated temperature (40 ° C) so that the lecithin left a thin film on the inner glass wall. By means of compressed air flushing last solvent residues were removed. The drug solution of the alkylamidothiazole was then also distributed to the flasks and the flasks were panned until the film had completely peeled off, but at least 15 minutes. Two different homogenization procedures were used: 5 minutes of medium-stage Ultraturrax or a 20-minute ultrasonic bath.
  • alkyloxysilanes as exemplified in EP 1 104287 B1
  • Nylon 12 1.0 1, 0

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Associations de principes actifs contenant des alkylamidothiazoles et une ou plusieurs cyclodextrines.
EP14717675.4A 2013-03-11 2014-02-11 Associations d'alkylamidothiazoles et de cyclodextrines Withdrawn EP2968104A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013204110.1A DE102013204110A1 (de) 2013-03-11 2013-03-11 Wirkstoffkombinationen aus Alkylamidothiazolen und einem oder mehreren Cyclodextrinen
PCT/EP2014/052614 WO2014139741A1 (fr) 2013-03-11 2014-02-11 Associations d'alkylamidothiazoles et de cyclodextrines

Publications (1)

Publication Number Publication Date
EP2968104A1 true EP2968104A1 (fr) 2016-01-20

Family

ID=50489056

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14717675.4A Withdrawn EP2968104A1 (fr) 2013-03-11 2014-02-11 Associations d'alkylamidothiazoles et de cyclodextrines

Country Status (4)

Country Link
EP (1) EP2968104A1 (fr)
CN (1) CN105073092A (fr)
DE (1) DE102013204110A1 (fr)
WO (1) WO2014139741A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013204088A1 (de) * 2013-03-11 2014-09-11 Beiersdorf Ag Wirkstoffkombinationen aus Alkylamidothiazolen und einen oder mehreren kosmetisch oder dermatologisch relevanten Duftstoffen
DE102013226711A1 (de) * 2013-12-19 2015-06-25 Beiersdorf Ag Verwendung von Alkylamidothiazolen in kosmetischen oder dermatologischen Zubereitungen zur Prophylaxe vor und Behandlung von sensibler Haut
DE102017201050A1 (de) * 2017-01-24 2018-07-26 Beiersdorf Ag Wirkstoffkombinationen aus Trans-4-t-butylcyclohexanol und einem oder mehreren Alkylamidothiazolen sowie kosmetische oder dermatologische Zubereitungen, diese Wirkstoffkombinationen enthaltend
DE202018004125U1 (de) 2018-09-05 2018-10-11 Beiersdorf Ag Alkylamidothiazole in Polypropylen-haltigen Packmitteln
WO2024207204A1 (fr) 2023-04-04 2024-10-10 Nivea (Shanghai) Co. Ltd. Combinaisons d'un ou de plusieurs alkylamidothiazoles, de tocophérol et d'acide 3-o-éthyl ascorbique et préparations cosmétiques contenant de telles combinaisons

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0241572A1 (fr) * 1984-11-01 1987-10-21 Sansho Seiyaku Co., Ltd. Composition cosmétique blanchissante

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4920132B2 (ja) 1998-08-13 2012-04-18 ゾル−ゲル テクノロジーズ エルティーディー． 機能性分子により充填されたオキシドマイクロカプセルの調製のための方法およびそれにより得られた生産物
GB2356386A (en) 1999-11-17 2001-05-23 Tagra Biotechnologies Ltd Microencapsulation
EP1941863A3 (fr) * 2002-07-25 2008-12-31 Lion Corporation Composition de préparation externe
WO2007013572A1 (fr) * 2005-07-29 2007-02-01 Shiseido Company, Ltd. Agent pour l’amélioration de l’élasticité/la structure de la chevelure, et la cosmétique du cheveu
JPWO2008038692A1 (ja) 2006-09-28 2010-01-28 萬有製薬株式会社 ジアリールケチミン誘導体
EP2250999B1 (fr) 2008-02-08 2016-04-13 Shiseido Company, Ltd. Agent blanchissant pour la peau et préparation externe pour la peau
DE102010012594A1 (de) * 2010-03-23 2011-09-29 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an einem oder mehreren Thiazolderivaten

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0241572A1 (fr) * 1984-11-01 1987-10-21 Sansho Seiyaku Co., Ltd. Composition cosmétique blanchissante

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2014139741A1 *

Also Published As

Publication number Publication date
WO2014139741A1 (fr) 2014-09-18
DE102013204110A1 (de) 2014-09-25
CN105073092A (zh) 2015-11-18

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