EP2959017A4 - Verfahren zur messung der il-6-expression zur bestimmung des risikos für chronische lungendysfunktion allogener transplantat - Google Patents

Verfahren zur messung der il-6-expression zur bestimmung des risikos für chronische lungendysfunktion allogener transplantat Download PDF

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Publication number
EP2959017A4
EP2959017A4 EP14754331.8A EP14754331A EP2959017A4 EP 2959017 A4 EP2959017 A4 EP 2959017A4 EP 14754331 A EP14754331 A EP 14754331A EP 2959017 A4 EP2959017 A4 EP 2959017A4
Authority
EP
European Patent Office
Prior art keywords
ling
dysfunction
expression
measuring
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14754331.8A
Other languages
English (en)
French (fr)
Other versions
EP2959017A1 (de
Inventor
Shaf Keshavjee
Mingyao Liu
Marcelo Cypel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Health Network
University of Health Network
Original Assignee
University Health Network
University of Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Health Network, University of Health Network filed Critical University Health Network
Priority to EP19197128.2A priority Critical patent/EP3653724A1/de
Publication of EP2959017A1 publication Critical patent/EP2959017A1/de
Publication of EP2959017A4 publication Critical patent/EP2959017A4/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4727—Calcium binding proteins, e.g. calmodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5412—IL-6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5428—IL-10
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP14754331.8A 2013-02-20 2014-02-20 Verfahren zur messung der il-6-expression zur bestimmung des risikos für chronische lungendysfunktion allogener transplantat Withdrawn EP2959017A4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP19197128.2A EP3653724A1 (de) 2013-02-20 2014-02-20 Verfahren zur bestimmung des risikos für eine chronische allotransplantat-lungendysfunktion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361766894P 2013-02-20 2013-02-20
PCT/CA2014/000139 WO2014127463A1 (en) 2013-02-20 2014-02-20 Methods of measuring il-6 expression to determine risk of chronic allograft ling dysfunction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP19197128.2A Division EP3653724A1 (de) 2013-02-20 2014-02-20 Verfahren zur bestimmung des risikos für eine chronische allotransplantat-lungendysfunktion

Publications (2)

Publication Number Publication Date
EP2959017A1 EP2959017A1 (de) 2015-12-30
EP2959017A4 true EP2959017A4 (de) 2017-01-11

Family

ID=51390435

Family Applications (2)

Application Number Title Priority Date Filing Date
EP14754331.8A Withdrawn EP2959017A4 (de) 2013-02-20 2014-02-20 Verfahren zur messung der il-6-expression zur bestimmung des risikos für chronische lungendysfunktion allogener transplantat
EP19197128.2A Pending EP3653724A1 (de) 2013-02-20 2014-02-20 Verfahren zur bestimmung des risikos für eine chronische allotransplantat-lungendysfunktion

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19197128.2A Pending EP3653724A1 (de) 2013-02-20 2014-02-20 Verfahren zur bestimmung des risikos für eine chronische allotransplantat-lungendysfunktion

Country Status (4)

Country Link
US (1) US10000809B2 (de)
EP (2) EP2959017A4 (de)
CA (1) CA2938893C (de)
WO (1) WO2014127463A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10975438B2 (en) 2016-09-08 2021-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for predicting chronic lung allograft dysfunction
DK3645735T3 (da) 2017-06-26 2021-10-25 Inst Nat Sante Rech Med Fremgangsmåde og sammensætning til forudsigelse af kronisk lungeallotransplantationsdysfunktion
CN116486922B (zh) * 2023-04-18 2024-01-23 中日友好医院(中日友好临床医学研究所) 一种基于基因多态性及血浆细胞因子的肺移植排斥预测方法及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8247175B2 (en) 2006-02-02 2012-08-21 University Health Network Diagnostic assay for lung transplant

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B. M. VANAUDENAERDE ET AL: "The Role of the IL23/IL17 Axis in Bronchiolitis Obliterans Syndrome After Lung Transplantation", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 8, no. 9, 1 September 2008 (2008-09-01), DK, pages 1911 - 1920, XP055294158, ISSN: 1600-6135, DOI: 10.1111/j.1600-6143.2008.02321.x *
S. HODGE ET AL: "Posttransplant Bronchiolitis Obliterans Syndrome Is Associated with Bronchial Epithelial to Mesenchymal Transition", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 9, no. 4, 1 April 2009 (2009-04-01), DK, pages 727 - 733, XP055294159, ISSN: 1600-6135, DOI: 10.1111/j.1600-6143.2009.02558.x *
SAITO T ET AL: "350 Biologic Subtyping of Human Chronic Lung Allograft Dysfunction", JOURNAL OF HEART AND LUNG TRANSPLANTATION, vol. 31, no. 4, April 2012 (2012-04-01), XP028910937, ISSN: 1053-2498, DOI: 10.1016/J.HEALUN.2012.01.359 *
See also references of WO2014127463A1 *
T. SAITO ET AL: "Impact of Cytokine Expression in the Pre-Implanted Donor Lung on the Development of Chronic Lung Allograft Dysfunction Subtypes", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 13, no. 12, 24 October 2013 (2013-10-24), DK, pages 3192 - 3201, XP055274037, ISSN: 1600-6135, DOI: 10.1111/ajt.12492 *

Also Published As

Publication number Publication date
WO2014127463A1 (en) 2014-08-28
US10000809B2 (en) 2018-06-19
EP3653724A9 (de) 2021-02-24
CA2938893A1 (en) 2014-08-28
EP3653724A1 (de) 2020-05-20
CA2938893C (en) 2022-12-13
EP2959017A1 (de) 2015-12-30
US20160002726A1 (en) 2016-01-07

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