EP2958883A4 - Cyclohexenone compositions and process for making thereof - Google Patents

Cyclohexenone compositions and process for making thereof

Info

Publication number
EP2958883A4
EP2958883A4 EP14754902.6A EP14754902A EP2958883A4 EP 2958883 A4 EP2958883 A4 EP 2958883A4 EP 14754902 A EP14754902 A EP 14754902A EP 2958883 A4 EP2958883 A4 EP 2958883A4
Authority
EP
European Patent Office
Prior art keywords
cyclohexenone
compositions
making
cyclohexenone compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14754902.6A
Other languages
German (de)
French (fr)
Other versions
EP2958883A1 (en
EP2958883B1 (en
Inventor
Sheng-Yung Liu
Wu-Che Wen
Chih-Ming Chen
Hsiu-Yi Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Golden Biotechnology Corp
Original Assignee
Golden Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Golden Biotechnology Corp filed Critical Golden Biotechnology Corp
Publication of EP2958883A1 publication Critical patent/EP2958883A1/en
Publication of EP2958883A4 publication Critical patent/EP2958883A4/en
Application granted granted Critical
Publication of EP2958883B1 publication Critical patent/EP2958883B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP14754902.6A 2013-02-20 2014-02-20 Cyclohexenone compositions and process for making thereof Not-in-force EP2958883B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767212P 2013-02-20 2013-02-20
PCT/US2014/017284 WO2014130618A1 (en) 2013-02-20 2014-02-20 Cyclohexenone compositions and process for making thereof

Publications (3)

Publication Number Publication Date
EP2958883A1 EP2958883A1 (en) 2015-12-30
EP2958883A4 true EP2958883A4 (en) 2016-08-17
EP2958883B1 EP2958883B1 (en) 2019-01-30

Family

ID=51391788

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14754902.6A Not-in-force EP2958883B1 (en) 2013-02-20 2014-02-20 Cyclohexenone compositions and process for making thereof

Country Status (9)

Country Link
US (2) US9365481B2 (en)
EP (1) EP2958883B1 (en)
JP (2) JP6706018B2 (en)
CN (1) CN105263893A (en)
CA (1) CA2901581C (en)
ES (1) ES2713181T3 (en)
HK (1) HK1220174A1 (en)
TW (1) TWI612026B (en)
WO (1) WO2014130618A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016037566A1 (en) * 2014-09-09 2016-03-17 Ching-Feng Weng Use of antroqiononol for treating obesity, and process for preparation of antroquinonol
US20160237012A1 (en) * 2015-02-17 2016-08-18 Golden Biotechnology Corporation Anticancer agents and process of making thereof
JP6932342B2 (en) * 2016-02-17 2021-09-08 ゴールデン バイオテクノロジー コーポレーション Compositions and Methods for Treating Liver Cancer
TW201831436A (en) * 2017-02-24 2018-09-01 郭盈妤 Compound isolated from Antrodia camphorata and applications therefor capable of being used as a pharmaceutical product to inhibit the growth of cancerous cells
AU2018247249B2 (en) 2017-12-20 2023-10-19 Golden Biotechnology Corporation Therapeutic compositions for treating pancreatic cancer
US11406605B2 (en) 2017-12-20 2022-08-09 Golden Biotechnology Corporation Therapeutic compositions for treating pancreatic cancer
CN111018686B (en) * 2019-11-19 2020-09-22 南通大学 6-benzylidene-2-aryl ethynyl cyclohexenone derivative and preparation method and medical application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012170720A2 (en) * 2011-06-10 2012-12-13 Golden Biotechnology Corporation Methods and compositions for treating brain cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101417934B (en) * 2007-10-24 2012-04-18 国鼎生物科技股份有限公司 New compounds separated from Antrodia camphorate extract
TWI389699B (en) * 2009-02-13 2013-03-21 Univ Kaohsiung Medical Ethanol extract of antrodia camphorata for inducing apoptosis and preparation method thereof
TWI394566B (en) * 2009-09-09 2013-05-01 Golden Biotechnology Corp Used to inhibit the growth of ovarian cancer tumor cells of the cattle camphor cyclohexene ketone compounds
TW201109023A (en) * 2009-09-09 2011-03-16 Golden Biotechnology Corp Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of colorectal cancer
TW201109013A (en) * 2009-09-09 2011-03-16 Golden Biotechnology Corp Cyclohexenone chemical compounds of Antrodia cinnamomea for suppressing the growth of the Lymphoma tumor cell
TWI444189B (en) * 2011-05-31 2014-07-11 Mackay Memorial Hospital Use of lanosta-8,24-dien-3β,15α,21-triol for inhibition of tumor cell growth

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012170720A2 (en) * 2011-06-10 2012-12-13 Golden Biotechnology Corporation Methods and compositions for treating brain cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2014130618A1 *

Also Published As

Publication number Publication date
CN105263893A (en) 2016-01-20
HK1220174A1 (en) 2017-04-28
US9365481B2 (en) 2016-06-14
US20160251308A1 (en) 2016-09-01
JP6706018B2 (en) 2020-06-03
CA2901581A1 (en) 2014-08-28
EP2958883A1 (en) 2015-12-30
CA2901581C (en) 2020-07-14
JP2016513122A (en) 2016-05-12
US20150018567A1 (en) 2015-01-15
WO2014130618A1 (en) 2014-08-28
EP2958883B1 (en) 2019-01-30
TWI612026B (en) 2018-01-21
TW201500330A (en) 2015-01-01
JP2019142854A (en) 2019-08-29
ES2713181T3 (en) 2019-05-20

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