EP2948134A4 - COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS - Google Patents

COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS

Info

Publication number
EP2948134A4
EP2948134A4 EP14743123.3A EP14743123A EP2948134A4 EP 2948134 A4 EP2948134 A4 EP 2948134A4 EP 14743123 A EP14743123 A EP 14743123A EP 2948134 A4 EP2948134 A4 EP 2948134A4
Authority
EP
European Patent Office
Prior art keywords
compositions
transdermal delivery
mtor inhibitors
mtor
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14743123.3A
Other languages
German (de)
French (fr)
Other versions
EP2948134A1 (en
EP2948134B1 (en
Inventor
Roger L Kaspar
Tycho Speaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palvella Therapeutics Inc
Original Assignee
Transderm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transderm Inc filed Critical Transderm Inc
Publication of EP2948134A1 publication Critical patent/EP2948134A1/en
Publication of EP2948134A4 publication Critical patent/EP2948134A4/en
Application granted granted Critical
Publication of EP2948134B1 publication Critical patent/EP2948134B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP14743123.3A 2013-01-24 2014-01-24 Compositions for transdermal delivery of mtor inhibitors Active EP2948134B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361756406P 2013-01-24 2013-01-24
PCT/US2014/013066 WO2014117035A1 (en) 2013-01-24 2014-01-24 COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS

Publications (3)

Publication Number Publication Date
EP2948134A1 EP2948134A1 (en) 2015-12-02
EP2948134A4 true EP2948134A4 (en) 2016-08-24
EP2948134B1 EP2948134B1 (en) 2020-03-04

Family

ID=51228089

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14743123.3A Active EP2948134B1 (en) 2013-01-24 2014-01-24 Compositions for transdermal delivery of mtor inhibitors

Country Status (7)

Country Link
US (1) US10172789B2 (en)
EP (1) EP2948134B1 (en)
AU (1) AU2014209141B2 (en)
CA (1) CA2899206C (en)
DK (1) DK2948134T3 (en)
ES (1) ES2797376T3 (en)
WO (1) WO2014117035A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063563A2 (en) 2006-11-16 2008-05-29 Transderm, Inc. Methods of treating keratin hyperproliferation disorders using mtor inhibitors
ES2797376T3 (en) 2013-01-24 2020-12-02 Palvella Therapeutics Inc Compositions for the transdermal administration of mTOR inhibitors
US20160184279A1 (en) * 2014-12-10 2016-06-30 Transderm, Inc. METHODS OF TREATING PAIN AND/OR ITCH WITH SMALL MOLECULE INHIBITORS TARGETING AN mTOR PATHWAY
EP3481411A4 (en) * 2016-07-11 2020-07-22 University of North Texas Health Science Center at Fort Worth Treatment for glaucoma and other eye diseases
US20190167649A1 (en) * 2016-08-10 2019-06-06 The Board Of Regents Of The University Of Texas System Topical rapamycin therapy
JP7108631B2 (en) 2017-01-06 2022-07-28 パルヴェラ セラピューティクス、インク． Anhydrous compositions of mTOR inhibitors and methods of use thereof
JP2020507422A (en) 2017-02-17 2020-03-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ Microneedle array containing active ingredients
JP2021530463A (en) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． Anhydrous composition of mTOR inhibitor and how to use it
MX2021010058A (en) * 2019-02-20 2021-11-12 Ai Therapeutics Inc Topical rapamycin formulations and their use in treating facial angiofibromas and other skin disorders.

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ES2797376T3 (en) 2020-12-02
WO2014117035A1 (en) 2014-07-31
EP2948134A1 (en) 2015-12-02
CA2899206A1 (en) 2014-07-31
DK2948134T3 (en) 2020-06-02
CA2899206C (en) 2019-07-09
EP2948134B1 (en) 2020-03-04
US10172789B2 (en) 2019-01-08
US20140315942A1 (en) 2014-10-23
AU2014209141A1 (en) 2015-08-20
AU2014209141B2 (en) 2018-05-10

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