EP2932940A1 - Dispositif médical extensible magnétiquement - Google Patents
Dispositif médical extensible magnétiquement Download PDFInfo
- Publication number
- EP2932940A1 EP2932940A1 EP15275096.4A EP15275096A EP2932940A1 EP 2932940 A1 EP2932940 A1 EP 2932940A1 EP 15275096 A EP15275096 A EP 15275096A EP 2932940 A1 EP2932940 A1 EP 2932940A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- body member
- magnetic elements
- magnetic
- strips
- graft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005291 magnetic effect Effects 0.000 claims abstract description 99
- 239000000696 magnetic material Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 14
- 239000002907 paramagnetic material Substances 0.000 claims description 5
- 238000003491 array Methods 0.000 description 6
- 230000002490 cerebral effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- -1 DyneemaTM Polymers 0.000 description 1
- 229910052779 Neodymium Inorganic materials 0.000 description 1
- 229910002837 PtCo Inorganic materials 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 1
- 229910001172 neodymium magnet Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 239000012781 shape memory material Substances 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/009—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof magnetic
Definitions
- the present invention relates to a magnetically expandable medical device, preferably an implantable medical device, and in the preferred embodiment to a magnetically expandable graft.
- a magnetically expandable medical device preferably an implantable medical device
- the teachings herein can also be used in a soft catheter or sleeve, for instance for an introducer assembly.
- Implantable medical devices are known in many forms and for treating many medical conditions. Examples include stents, grafts, filters, occluders, valve replacement prostheses and so on. Such devices are generally introduced into the patient endoluminally through a remote percutaneous entry point. In order to achieve this, the medical device is loaded onto a carrier at a distal end of an introducer assembly with the device being held in a radially compressed configuration. The introducer assembly is fed into the patient's vasculature from the percutaneous entry point until its distal end is located at the treatment site. Once so positioned, the medical device is released from the carrier and expanded until the device engages the vessel wall to be held thereby.
- the device can be of a type which expands automatically, achieved by use of spring material, shape memory material and so on.
- Other types of device are plastically deformable and expanded by a separate mechanism, for instance by inflation of a delivery balloon on which the device is held in crimped form.
- the medical device applies a constant force against the walls of the vessel in which it is located. This ensures good patency to the vessel wall, that is, a good seal between the device and the wall tissue, in order to stop leakage around the device.
- the application of constant force also ensures that the device does not migrate or rotate out of alignment over time.
- the force produced by the above-mentioned medical devices is a mechanical force, be it by a spring force of the components of the device or by relative mechanical stiffness in the case of plastically deformable devices.
- such devices have a relatively high volume of foreign material which is implanted and left in the patient's body.
- the structure of such devices can impart unnatural forces on the vessel wall, the most common being a vessel straightening force acting against the natural curvature of the vessel or a significant pressing force against the sides of the vessel. Such forces can lead to restenosis of the vessel.
- implantable medical devices are disclosed in US 2011/0257724 , US 2006/0212113 , US 8,449,604 and US 7,722,668 .
- the present invention seeks to provide an improved implantable medical device and an introducer assembly therefor.
- the device may be, but is not limited to, a vascular graft.
- a medical device including an expandable body member having at least first and second sides with opposing internal surfaces, at least first and second magnetic elements each located at a respective one of said opposing internal surfaces as to be disposed in opposing relation to one another, wherein each magnetic element has a north pole and a south pole, the magnetic elements being disposed so as to have similar poles facing one another thereby to generate a repulsive force between one another.
- the magnetic elements are arranged such that the same pole faces inwardly towards the central axis of the device, and the opposing pole faces outwardly.
- the magnetic elements may be disposed such that their south poles face in the same direction as the internal surfaces of the body member, with their north poles facing outwardly.
- the magnetic elements could be oriented in the opposite direction.
- the device is preferably an implantable medical device, such as a prosthesis.
- a medical device of such a structure does not need to rely upon the generation of a mechanical force as with conventional medical devices, but instead makes use of constant magnetic repulsion to keep the body member of the device in its expanded state against the vessel wall. As a result of the use of such magnetic forces it is not necessary to generate large opening forces to hold the device in place.
- the device can in practice be much more flexible and able to configure to the shape of the vessel or other organ, as well as accommodating changes in the vessel during normal body function and over time. This enhanced flexibility also makes the device suitable for the cerebral vessels.
- the device may be any expandable prosthesis. It may be a graft, stent, filter, occluder, valve replacement prosthesis, for example.
- the teachings herein could also be used for other medical devices, such as catheters and the like, enabling the provision of a soft catheter for delicate vessels for instance.
- the body member has a tubular or conical shape and may be formed of woven, knitted, braided or sheet material.
- the device may be or include a graft, the graft forming the body member.
- the magnetic elements are disks or rods, which may be generally circular, although could have other shapes such as oval, square or rectangular.
- first and second lines of said magnetic elements may be provided along the body portion of the device.
- the lines of magnetic elements extend parallel to an axial or longitudinal dimension of the body member, although in another embodiment the lines of magnetic elements extend at an angle to the axial dimension of the body member. They may, for example, extend helically or in a zigzag manner along the body member. In some embodiments, the magnetic elements may extend circumferentially around the body member, as a simple annular shape or in any other shape including undulating and zigzag.
- the magnetic elements are strips of magnetic material, which may extend parallel to the axial or longitudinal dimension of the body member or at an angle thereto.
- the strips of magnetic material may have the same shapes as characteristics as the lines of magnetic elements.
- the strips may be discontinuous along the length of the body member.
- the magnetic elements may be painted on or attached to the body member of the device.
- the magnetic elements are formed of paramagnetic material, which can be magnetised once the elements have been fitted to the body member of the device.
- the magnetic elements are formed of biodegradable material, preferably of a material which will degrade at a rate slower than a rate of ingrowth of vessel tissue.
- the embodiments described below are directed to a graft of tubular and substantially cylindrical form.
- the teachings herein are particularly suited to vascular grafts, although it is to be understood that the teachings herein are not limited to a graft of this structure and are equally applicable to grafts having a non-uniform shape and/or size along its length, such as a tapering graft, a graft with a central waist and so on. Equally, the teachings herein are also applicable to other forms of medical device, including devices provided with graft elements or other coverings and also medical devices having no graft element, such as stents and so on.
- the graft 10 shown in schematic form includes a body member 12 of generally tubular form and made of, in this example, a conventional graft material, typically woven or knitted.
- the graft material could be of ultrahigh molecular weight polyethylene, such as DyneemaTM, Expanded polytetrafluoroethylene (ePTFE) or any other suitable or known material.
- the tubular graft element 12 includes an outer abluminal surface 14 and an inner luminal surface 16. Attached to graft element 12 is a plurality of magnetic elements 20.
- the elements 20 are, in this example, arranged in four arrays or lines 22, 24, 26 and 28 which extend along the length of the tubular graft element 12 and in this embodiment substantially parallel to the longitudinal axis of the graft element 12.
- the arrays or lines 22-28 of magnetic elements 20 are arranged in opposing pairs. More specifically, the arrays or lines 22 and 24 are disposed on opposite sides of the internal surface 16 of the graft element 12 and the pair of arrays or lines 26 or 28 are likewise disposed opposite one another.
- the four arrays or lines 22, 28 are equally spaced circumferentially around the graft tube 12 so in this example separated from one another by 90° around the graft tube.
- the magnetic elements 20 each have north and south poles and are disposed on the graft tube such that they have the same pole facing inwardly, towards the central axis of the graft tube.
- the south pole of the magnetic elements 20 faces towards the radial centre of the graft tube 12.
- all of the magnetic elements 20 have the opposing pole, in this example, the north pole, facing outwardly of the graft tube.
- the polarities of all the magnets could be reversed relative to those depicted.
- the magnetic elements could in their simplest form be formed of a magnetic material printed or otherwise applied to the material of the graft tube 12 or can be magnetic disks or other three-dimensional structures mechanically affixed to the graft tube 12, for instance by bonding, riveting or the like.
- Suitable stents include stents having a zigzag form for radial compressibility. Each stent could be sewn to a respective end of the graft tube 12 and disposed either inside or outside the graft tube 12. Such stents can be useful in embodiments in which only a few magnetic elements 20 are disposed circumferentially around the graft.
- Figure 2 shows a cross-sectional view of the graft of Figure 1 , in schematic form.
- Figure 2 shows arrows 30-36 which depict the magnetic force generated at each of the magnetic elements 22-28 as the result of the opposing magnetic relation with the corresponding magnetic element on the opposing side of the graft tube 12. More specifically, in the described embodiment, the facing south poles of the magnetic elements 22, 24 will produce mutually repulsive magnetic forces in the directions of arrows 30 and 32. Likewise, the opposing magnetic elements 26 and 28 will, by virtue of having their south poles facing one another, also generate mutually repulsive magnetic forces 34 and 36 in opposing directions. These repulsive magnetic forces 30-36 will cause the graft element to be biased in the open configuration, as will be apparent from the schematic diagram of Figure 2 .
- each magnetic element 20 has a directly facing counterpart on the opposing side of the graft tube 12, that is opposing in the radial direction as well in the longitudinal direction along the length of the graft element 12. It is not excluded, however, that the magnetic elements 20 could be slightly offset relative to their opposing counterpart, either in the circumferential direction or in the longitudinal direction or both. However, the offset will produce a lower repulsive force.
- Figures 1 and 2 depict an embodiment having two sets of magnetic elements 22, 24 and 26, 28. It is envisaged that some embodiments may have more than two pairs of sets of magnetic elements 20, for instance 4, 6, 8 or more pairs, which again are preferably evenly spaced circumferentially around the tubular graft element 12. Each opposing set of magnetic elements would produce repulsive magnetic forces as with the embodiment of Figure 2 , with the addition of further magnetic repulsion between adjacent magnetic elements 20, enhancing the opening of the medical device 10. It is to be understood, though, that in most embodiments it is not necessary to have many magnetic elements 20 on the graft tube 12 as blood flow will tend to keep the graft tube open, the magnetic elements being provided to ensure there is no collapse of the graft tube.
- FIG. 3 shows another embodiment of implantable medical device 40, which again has a tubular graft element 12 similar to that of the embodiment of Figures 1 and 2 and having similar characteristics.
- the disk-shaped magnetic elements 22 of the embodiment of Figures 1 and 2 are replaced by strips of magnetic material 42-48, which extend along the length of the graft tube 12, which forms the body portion of the medical device 40.
- the strips of magnetic material 42-48 extend, in this embodiment, substantially parallel to the longitudinal axis of the tubular graft element 12 and are arranged in opposing pairs, that is with the strips 42, 46 being on opposing sides of the graft tube 12, the strips 44 and 48 extending in like manner.
- the strips 42-48 have north and south polarities and are arranged such that the same polarity faces internally into the luminal side 16 of the graft tube 12 and the opposite polarity faces the abluminal side 16.
- the south pole of each magnetic strip 42-48 extends towards the interior of the graft tube 12 and the north pole faces to the exterior.
- This arrangement of strips of magnetic material 42-48 provides a very similar functionality to the embodiments of Figures 1 and 2 , with a smaller number of magnetic elements being necessary. Again, these strips of magnetic material 42-48 could be provided by printing magnetic material onto the graft tube or by affixing three-dimensional strips to the graft tube.
- the strips 42-48 are continuous along the whole length of the graft element 12, although it is not excluded that these could be discontinuous, that is segmented with or without a gap between adjacent segments of each strip 42-48. Segmenting the strips of magnetic material 42-48 can enhance the longitudinal flexibility of the medical device 40, as will be apparent from the teachings below.
- Figure 4 shows the implantable medical device 10 of Figures 1 and 2 disposed within a vessel 50 of a patient.
- the vessel 50 is shown in cross-section, whereas the implantable medical device 10 is shown in its complete form.
- Figure 4 also shows the direction of the magnetic repulsive forces 34 and 36 generated by the opposing sets 26, 28 of magnetic elements 20 and the skilled person will appreciate that the equivalent opposing magnetic forces will be generated also at the sets 22 and 24 of magnetic elements and any other opposing sets of magnetic elements.
- the opposing magnetic forces 34, 36 cause the graft element 12 to be pressed against the vessel wall 50 and thereby ensure that the tubular graft element 12 remains open within the vessel.
- the repulsive magnetic forces provide a constant opening force to the medical device 10 irrespective of other factors such as vessel movement and the like.
- the opening force is magnetic
- the magnetic elements 20 it is not necessary for the magnetic elements 20 to be particularly large and the graft tube 12 (or other structure of another form of medical device) similarly need not be thick or otherwise voluminous.
- the medical device 10, therefore, can be very thin, as a result presenting virtually no or otherwise minimal disruption to the flow of fluid within the vessel 50. This can also minimise the amount of foreign material in the body.
- these characteristics also make the device suitable for smaller vessels.
- FIG. 5 this shows the implantable medical device 10 deployed within a curved vessel 60.
- the medical device 10 is the same as that of Figure 4 and the embodiments of Figures 1 and 2 , although it is not excluded that the device 10 could be shaped to correspond with the shape of the vessel 60.
- the opposing magnetic elements will generate the same repulsive magnetic forces but these will be directed in the orthogonal direction relative to the axis vessel 60, thereby ensuring that the graft tubing 12 remains consistently pressed against the vessel wall along the curve, thereby keeping the graft tubing 12 open and in position.
- These opposing repulsive magnetic forces will therefore be aligned with the curvature of the vessel 60, as depicted in Figure 5 .
- the magnetic elements could be made from permanent magnets and equally could be made from a paramagnetic material and magnetised after fixation to the body portion of the medical device, for example by means of an electromagnet or a permanent magnetic field.
- the elements would be magnetised to ensure that the relative polarisation direction of each spot or magnetic strip is identical.
- the magnetic element 20 is in the form of a disk or rivet which extends through the body member 12.
- the magnetic element 20 is made of a paramagnetic material and magnetisation thereof is achieved by providing electromagnets 72, 74 either side of each magnetic element.
- the electromagnet 76 can usefully be in the form of a mandrel which is fed into the lumen of the graft.
- the electromagnet 74 could be a series of electromagnetic elements or a sleeve.
- the electromagnets 74 and 76 are energised to cause the paramagnetic material of the element 20 to be polarised, in this example to have its south pole on the interior surface of the body member 12 and its north pole extending outwardly of the body portion 12 and therefore of the device 10.
- the method of magnetisation of a paramagnetic element 20 may be by means of a permanent magnet or electromagnetically.
- arrays or lines of magnetic elements or strips of magnetic element which extend parallel to the longitudinal axis of the body portion of the medical device 10.
- the magnetic elements may extend at an angle to the longitudinal axis and could, for example, extend helically around the body portion or even in zigzag or other curved shape.
- the exact arrangement and/or shape of the magnetic elements can be varied to give the device 10 different opening characteristics. Equally, some parts of the body portion of the device 10 can be free of magnetic elements in some embodiments.
- magnétique elements could extend circumferentially around the body portion, in one or more annular bands.
- Each strip could be simply annular or undulating or of zigzag form.
- the medical device 10 could be deployed in a patient's vessel over an inflatable delivery balloon.
- a balloon can ensure that the body member 12 of the device is expanded properly against the vessel wall, with the magnetic elements 20 then ensuring that the device 10 expands as desired.
- the magnetic elements could be made of: NdFeB (neodymium), FeCrCo, SMCo or PtCo.
- the magnetic elements could have a thickness of 0.10 millimetres or more.
- the magnetic elements are formed from a biodegradable or bioabsorbable material, likewise with the other elements of the device.
- the medical device it is not necessary for the medical device to have a graft element.
- the magnetic elements could be fitted, for example, to a stent or other open structure, for example allowing the stent to have a smaller and weaker mechanical structure than conventional stents.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Prostheses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1406658.3A GB2525385B (en) | 2014-04-14 | 2014-04-14 | Magnetically expandable medical device |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2932940A1 true EP2932940A1 (fr) | 2015-10-21 |
EP2932940B1 EP2932940B1 (fr) | 2021-08-11 |
Family
ID=50844948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15275096.4A Active EP2932940B1 (fr) | 2014-04-14 | 2015-03-30 | Dispositif médical extensible magnétiquement |
Country Status (3)
Country | Link |
---|---|
US (1) | US20150290000A1 (fr) |
EP (1) | EP2932940B1 (fr) |
GB (1) | GB2525385B (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US12004940B2 (en) * | 2019-10-01 | 2024-06-11 | Yale University | Transcatheter device, system and method for treating type a aortic dissection |
US20210267779A1 (en) * | 2020-03-02 | 2021-09-02 | Gyrus Acmi, Inc. D/B/A Olympus Surgical Technologies America | Magnetically deployable urinary stent |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090287293A1 (en) * | 2008-05-15 | 2009-11-19 | Mailhot Jr Robert | Magnetically induced radial expansion vascular stent |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6673104B2 (en) * | 2001-03-15 | 2004-01-06 | Scimed Life Systems, Inc. | Magnetic stent |
US8029570B2 (en) * | 2001-09-28 | 2011-10-04 | Mayo Foundation For Medical Education And Research | Implantation of magnets in bone to reduce contact pressure |
US7481224B2 (en) * | 2003-01-22 | 2009-01-27 | Koninklijke Philips Electronics N.V. | Magnetic force device, systems, and methods for resisting tissue collapse within the pharyngeal conduit |
JP2007503291A (ja) * | 2003-06-09 | 2007-02-22 | サイトリ セラピューティクス インコーポレイテッド | 螺旋管腔内ステント及び関連方法 |
US20070118216A1 (en) * | 2005-11-21 | 2007-05-24 | Joel Pynson | Accommodative intraocular lens |
WO2007075593A1 (fr) * | 2005-12-20 | 2007-07-05 | The Cleveland Clinic Foundation | Appareil et procede de modulation du systeme baroreflexe |
US9211179B2 (en) * | 2013-02-26 | 2015-12-15 | Medtronic, Inc. | Embolic protection device |
-
2014
- 2014-04-14 GB GB1406658.3A patent/GB2525385B/en active Active
-
2015
- 2015-03-30 EP EP15275096.4A patent/EP2932940B1/fr active Active
- 2015-04-13 US US14/684,681 patent/US20150290000A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090287293A1 (en) * | 2008-05-15 | 2009-11-19 | Mailhot Jr Robert | Magnetically induced radial expansion vascular stent |
Also Published As
Publication number | Publication date |
---|---|
GB2525385B (en) | 2016-03-09 |
GB201406658D0 (en) | 2014-05-28 |
US20150290000A1 (en) | 2015-10-15 |
GB2525385A (en) | 2015-10-28 |
EP2932940B1 (fr) | 2021-08-11 |
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