EP2925442A1 - Cartridge having electrical sliding contact, and method - Google Patents
Cartridge having electrical sliding contact, and methodInfo
- Publication number
- EP2925442A1 EP2925442A1 EP13794898.0A EP13794898A EP2925442A1 EP 2925442 A1 EP2925442 A1 EP 2925442A1 EP 13794898 A EP13794898 A EP 13794898A EP 2925442 A1 EP2925442 A1 EP 2925442A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cartridge
- drum
- electrical
- conductor tracks
- electrical conductor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0609—Holders integrated in container to position an object
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0841—Drums
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
Definitions
- biochemical processes are based in particular on the handling of liquids. Typically, this manipulation is done manually with tools such as pipettes, reaction vessels, active probe surfaces or laboratory equipment. By pipetting robots or special equipment, these processes are already partially automated.
- Lab-on-a-Chip systems (also referred to as the West Pocket Laboratory or the Chiplabor) accommodate all the functionality of a macroscopic laboratory on a plastic plastic-sized plastic substrate. Lab-on-a-chip systems typically consist of two major components.
- a test carrier includes structures and
- Reagents or even active components such as valves or pumps can exist.
- the second main component is actuation, detection and control units. Such systems make it possible to carry out biochemical processes fully automatically.
- a lab-on-a-chip system is described for example in the document DE 10 2006 003 532 AI. This system includes a rotor chip which faces one
- Statorchip is rotatably provided.
- the rotor chip can be coupled by means of fluidic channels with the stator chip for filling or emptying the rotor chip.
- the structures of the present cartridge can also be transferred identically to externally pressure-actuated systems.
- the present method also has the advantage of allowing electrical supply to a consumer (such as a sensor or a heater) in the rotating drum during centrifugation of the cartridge without the use of cables.
- a consumer such as a sensor or a heater
- the inventive transmission of electrical energy from the power source to the consumer in the drum allows a simple construction structure for the power line and its interface between the housing of the cartridge and the drum, which advantageously the cost of the cartridge are kept low can.
- the present cartridge is advantageously independent of an external power supply for the operation of the devices, and therefore the extended functionality of the cartridge in connection with the devices is further available with existing centrifuges and thus retrofitting the centrifuges is unnecessary.
- each drum may be provided with an individual device, which in turn is separately activated and controlled.
- the present cartridge advantageously provides an autonomous system for processing a component, in which the respective running processes are carried out in a drum with the aid of the devices, and thus of one
- the arrangement of the device inside the drum provides for immediate processing of the component and thus rapid changes in the respective components of the component. Since the control unit for the device is provided in the cartridge, the execution of the processing is easy to handle, so that a presetting of operating parameters can advantageously be dispensed with.
- the power source can be easily separated and discarded after performing the analysis of the component from the cartridge.
- Component in the present case means a liquid, a gas or one or more particles.
- first and second component only two different states of the same substance may be meant:
- the first component may be formed as a clumped portion and the second component as a liquid portion of the same substance.
- the electrical contact elements are electrically conductively connected to a semiconductor component on a printed circuit board, which is coupled to the drum.
- the printed circuit board preferably contains electrically functional structures, such as, for example, a heating resistor, in particular a meandering arrangement, or a temperature-dependent one
- the semiconductor element may be, for example, a
- the semiconductor element may also be a chem-FET or an amperometric sensor.
- Microcontroller, microprocessor or microchip contains all the circuit logic for performing a control of the semiconductor device during the closed circuit inside the cartridge.
- a further embodiment of the cartridge according to the invention realized in the closed state of the electrical contact elements with the electrical Conductors driving the semiconductor device by the microcontroller, a variable output of electrical energy to the semiconductor device.
- the electrical energy to the semiconductor element in a closed circuit not only constant, but also be provided controlled or triggered.
- cyclic heating of the chamber which is switchable by means of contacting the electrical conductor tracks with the electrical contact elements for heating.
- electrical conductor tracks are arranged on the inside of the housing.
- the electrical conductor tracks may be arranged extending inside the wall of the housing or on the inner surface of the housing.
- the electrical conductor tracks are in the form of an injection-molded circuit carrier (MID)
- the MIDs molded interconnect device
- the MIDs are further connected to an energy source for supplying the cartridge with electrical energy.
- Circuit board further end at least two tabs on which an electrical contact element is formed in each case, wherein the electrical contact elements are contactable with a first pair of electrical conductor tracks.
- the two tabs are preferably arranged opposite to the end regions of the printed circuit board.
- the electrical contact element is preferably an electrically conductive coating in the region of the tab of the printed circuit board.
- the circuit board further tabs, to which in turn in each case an electrical
- the electrical conductor tracks are wired or wirelessly connectable to a power source to generate a current flow therethrough in the closed state of the electrical contact elements with the electrical conductor tracks.
- Wireless solutions can make use of coils, a battery or an accumulator in the cartridge.
- An adjusting means comprises a first ramp which cooperates with a second ramp of the drum to move the drum from a first position in which the second ramp positively engages a housing of the cartridge in a rotational direction about the central axis to a second position along the central axis spend in which the positive connection is lifted and the drum rotates about the central axis.
- This mechanism is also referred to as a "ballpoint pen mechanism" herein.
- the electrical conductor tracks instead of on the housing of the cartridge on the
- the electrical conductor tracks are preferably arranged in the region of the first slope of the adjusting device and with the
- Power source for supplying the cartridge electrically connected to electrical energy, so that the electrical contact elements of the drum at a suitable position of the drum close the circuit.
- the electrical contact elements of the drum are second electrical conductor tracks, which are electrically conductively connected to the semiconductor component on the circuit board.
- FIG. 1 a perspective view of a cartridge without a drum according to an embodiment of the present invention
- FIG. 1 a perspective view of the opening portion of the cartridge of Figure 1
- a drum of the cartridge of Figure 1 in the manner of a rotary turret
- a side view of the drum of Figure 3 in a partial view of a contactless state between electrical contact elements of a printed circuit board and the cartridge of Figure 1; in a partial view of a contact state between electrical
- FIG. 1 shows a perspective view of a cartridge 100 without a drum according to an embodiment of the present invention.
- the cartridge 100 includes a housing 110 in the form of a tube.
- the housing 110 can be designed as a 5 to 100 ml, in particular 50 ml, centrifuge tube, 1.5 ml or 2 ml eppendorf tube or, alternatively, as a microtiter plate (eg, 20 ⁇ per cavity).
- a drum (not shown) is accommodated.
- the housing 110 is formed closed at its one end 112.
- the other end 116 of the housing 110 is closed by means of a closure 118.
- the closure 118 may be removed to remove the drum from the housing 110.
- the housing 110 itself can be disassembled to remove the drum or to reach a chamber (not shown) in the drum.
- the closure 118 is preferably designed for supplying power to the drum, wherein the power supply can be designed as a reusable component or device which is part of the cartridge 100 during operation thereof.
- the closure 118 may be detachably provided with an integrated accumulator (not shown) or a battery (not shown).
- the housing 110 and the drum 10 may be made of the same or different polymers.
- the one or more polymers are, in particular, thermoplastics, elastomers or thermoplastic elastomers.
- cycloolefin polymer COP
- cycloolefin copolymer COC
- PC polycarbonates
- PA polyamides
- PU polyurethanes
- PP polypropylene
- PET polyethylene terephthalate
- PMMA poly (methyl methacrylate)
- Conductor tracks 50, 60 preferably in the form of an injection-molded circuit carrier (MID) formed.
- a region of the electrical conductor tracks 50, 60 extends in each case in the region of the open end 116 of the cartridge 100, and thus serves as an interface for making contact with the power supply of the shutter 118.
- the electrical conductor tracks 50, 60 extend substantially in the vertical direction toward the end 112 up to a predetermined length, which is defined by a multiplicity of circumferentially regularly spaced teeth 35 of an adjusting device (see FIGS. 5 and 6) becomes.
- the electrical conductors 50, 60 are with selected teeth 35 of
- Adjustment device electrically connected.
- the underside of the teeth 35 each have a first slope 201.
- the electrical conductors 50, 60 may also be coated with a protective layer.
- the electrical traces 50, 60 typically have a thickness of a few nanometers (e.g., 50 nm) to a few millimeters (e.g., 3 mm), or may be designed as wires.
- the width of the electrical conductor tracks 50, 60 can vary from a few micrometers to a few millimeters.
- the electrical interconnects 50, 60 may include metallic materials such as copper, gold, aluminum, platinum, titanium their alloys or doped semiconductor materials such as silicon.
- FIG. 2 shows a perspective view of the opening region 116 of the cartridge 100 from FIG. 1.
- a region 51 of the electrical conductor tracks 50, 60 extends in each case in the region of the open end 116 of the cartridge 100, and thus serves as an interface to the
- Cartridge 100 formed and are formed offset in the depth direction of the housing 110.
- FIG. 3 shows a drum 10 for the cartridge 100 from FIG. 1 in the manner of a revolving turret.
- the drum 10 is a substantially thin-walled container having in its interior a chamber 20 for receiving a component, for example, a biological sample of a person to be examined or any chemical substance.
- a circuit board 150 is arranged, which is a substantially flat element.
- the printed circuit board 150 has an approximately rectangular central region, wherein in the region of the upper transverse end in each case tabs 160, 170 extend away from the central region.
- the circuit board 150 is mirror-symmetrical.
- an electrical contact element 30, 40 is formed, which is suitable for a
- the circuit board 150 further includes electrically functional structures that can heat the component, for example.
- the chamber 20 may be provided in the region of its inner peripheral surface with a heat insulation, for example by means of phase change materials.
- a heat insulation for example by means of phase change materials.
- the heat insulation in the outer peripheral region of the drum 10 may be arranged completely or in sections.
- a plurality of teeth 45 of an adjusting device which each extend along the entire height of the drum 10.
- the underside of the teeth 45 is formed flush with the underside of the chamber 20.
- the teeth 45 project in each case by a predetermined height beyond the height of the drum 10, wherein the free end of the teeth 45 is formed in the form of a bevel 47.
- FIG. 4 shows a side view of the drum 10 from FIG. 3, wherein the drum 10 in the region of the upper end of the chamber 20 has respective slot-like recesses 12 arranged opposite one another, which are provided for receiving the tabs 160, 170 of the printed circuit board 150.
- the slot-like recess 12 is in the region of the upper end of the chamber 20 each have a nose 13 is formed, which extends slightly spaced in the circumferential direction to the outer peripheral surface of the drum 10.
- the nose 13 is in communication with the slot-like recess 12 provided for connecting the circuit board 150 to the drum 10, wherein the nose
- the circuit board 150 is inclined in the installed position with respect to a vertical plane, which is why the tabs 160, 170 of the circuit board 150 in the lugs 13 additionally jammed. This embodiment of the attachment for the circuit board 150 in the
- Drum 10 can be produced in an advantageous manner by injection molding, which can be dispensed with a slide for undercuts.
- FIG. 5 shows a partial view of a contactless state between the two
- Adjustment device 200 is formed, which causes the actuation of the
- Regulating device 200 the drum 10 relative to the housing 110 of the cartridge 100 in a predetermined direction by a predetermined angle rotates (. Actuation of the ballpoint pen mechanism ').
- the electrical conductor tracks 50, 60 formed inside the housing 110 of the cartridge 100 do not contact the respective electrical contact elements (not shown) of the printed circuit board 150, the electrical function on the printed circuit board 150 can in this position not be activated. Rather, the electrical contact elements of the printed circuit board 150 are rotated relative to the electrical conductor tracks 50, 60. A closing of the
- Circuit within the cartridge 100 is possible only after a further actuation of the adjusting device 200.
- 6 shows in a partial view a contact state between the electrical contact elements 30, 40 of a printed circuit board 150 and the cartridge of Figure 1.
- the drum is rotated relative to the position of Figure 5 by a tooth position, now the electrical Conductor tracks 50, 60 with the respective electrical contact elements (not shown) of the circuit board 150 are in contact.
- the circuit within the cartridge 100 is closed and the circuit board 150 is now for the duration of this position until the re-actuation of the Adjusting device 200 are supplied with electrical energy.
- the electrical function on the circuit board 150 is activated.
- Figure 7 shows a schematic representation of a sliding contact for a
- FIGS. 7 and 8 a plurality of teeth are shown in the upper area thereof, which are assigned to the inner peripheral area of the housing of the cartridge (not shown). Accordingly, in the lower portion of Figs. 7 and 8, a plurality of teeth are shown, which are to be assigned to the outer peripheral portion of the drum 10.
- FIG. 7 shows a further embodiment of the arrangement of the electrical strip 30 for supplying a printed circuit board (not shown) of the drum 10.
- the views of FIGS. 7 and 8 show only one electrical strip 30 at a time
- an electrical contact 55 in the form of an injection-molded circuit carrier (MID) is formed on the housing of the cartridge.
- the electrical contact 55 has in the region of the free end of the tooth 35 a shape which is substantially identical to that of the tooth 35.
- the electrical contact 55 is electrically connected to a power source (not shown) of the cartridge.
- the electrical trace 30 is electrically connected to the printed circuit board of the drum 10, so that by means of this an electrical function (for example the detection of a temperature or the heating of a component in the drum 10 can be realized.)
- an electrical function for example the detection of a temperature or the heating of a component in the drum 10 can be realized.
- an electrical contact 55 in the form of an injection-molded circuit carrier (MID) is formed on the housing of the cartridge.
- the electrical contact 55 has in the region of the free end of the tooth 35 a shape which is substantially identical to that of the tooth 35.
- the electrical contact 55 is formed in the area between two adjacent teeth.
- the electrical contact 55 is electrically connected to a power source (not shown) of the cartridge.
- the electrical trace 30 is electrically connected to the circuit board of the drum 10, so that with the aid of this an electrical function (for example, the detection of a temperature or the heating of a component in the drum 10 can be realized Contact 55 of the cartridge with the electrical trace 30 of the drum 10 comes into contact, then the circuit is closed and an electrical function is performed in the drum 10.
- FIG. 9 schematically shows a view of a printed circuit board 150 with a heating device 310 for a cartridge according to a further exemplary embodiment of the present disclosure
- the printed circuit board 150 is a planar component and has in each case a tab 160 and 170 in the upper region of its longitudinal ends.
- the heating device 310 for the circuit board 150 is formed in the manner of a heating meander, which is located in the
- Temperature-dependent resistor 300 is arranged as a semiconductor element, which is arranged above the heater 310.
- the temperature-dependent resistor 300 is arranged as a semiconductor element, which is arranged above the heater 310.
- Resistor 300 may be used as a temperature control element.
- Figure 10 shows schematically a view of a printed circuit board 150 with a control for a heater 300, 350 for a cartridge according to yet another
- the circuit board 150 is again a planar component and has in the upper region of its longitudinal ends in each case a tab 160 and 170.
- Heating device consists of a temperature sensor 300 and an actuator 350, which is electrically connected in series with the temperature sensor 300.
- the temperature sensor 300 and the actuator 350 are electrically connected to electrical contact elements 30, 40 which in turn are formed in the upper region of the printed circuit board 150 with tabs 160 and 170 respectively formed at their longitudinal ends.
- the temperature sensor 300 measures the temperature of a component (not shown) and the actuator 350 adjusts this sensed temperature as a control. It is also possible to measure and regulate parameters other than the temperature when choosing another sensor. Alternatively, amperometric sensors or chem FETs, etc. may be used. A regulation or a control of the actuator 350 and / or the temperature sensor 300 takes place with the aid of a microcontroller 360, which is likewise electrically connected to the electrical contact elements 30, 40.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102012221734.7A DE102012221734A1 (en) | 2012-11-28 | 2012-11-28 | Cartridge with electric sliding contact and process |
PCT/EP2013/074332 WO2014082911A1 (en) | 2012-11-28 | 2013-11-21 | Cartridge having electrical sliding contact, and method |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2925442A1 true EP2925442A1 (en) | 2015-10-07 |
EP2925442B1 EP2925442B1 (en) | 2017-01-11 |
Family
ID=49626958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13794898.0A Not-in-force EP2925442B1 (en) | 2012-11-28 | 2013-11-21 | Cartridge with electrical slide contact as well as process |
Country Status (5)
Country | Link |
---|---|
US (1) | US20150298126A1 (en) |
EP (1) | EP2925442B1 (en) |
CN (1) | CN104797341A (en) |
DE (1) | DE102012221734A1 (en) |
WO (1) | WO2014082911A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102018121787A1 (en) * | 2018-09-06 | 2020-03-12 | Endress+Hauser Conducta Gmbh+Co. Kg | Electrode assembly, amperometric sensor, its manufacture and use |
CN110095521B (en) | 2019-05-13 | 2022-08-23 | 京东方科技集团股份有限公司 | Centrifuge tube, detection system and detection method |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9716052D0 (en) * | 1996-12-06 | 1997-10-01 | Secr Defence | Reaction vessels |
CN2492317Y (en) * | 2001-06-11 | 2002-05-22 | 王晓钰 | Multifunctional centrifuge specially for milk product test |
CN100344874C (en) * | 2003-01-28 | 2007-10-24 | 清华大学 | Fluid transmission method and minisize peristaltic pump for realizing the same |
JP2004309145A (en) * | 2003-04-02 | 2004-11-04 | Hitachi High-Technologies Corp | Chemical analysis device and structure for chemical analysis |
DE102006003532B4 (en) | 2006-01-24 | 2008-11-20 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Microfluidic device and modular lab-on-a-chip system |
DE102006056822A1 (en) * | 2006-12-01 | 2008-06-05 | Reimer Offen | Tempered sample acceptor for e.g. tempering body-inherent liquid, has hollow needle made of steel, attached on coatings for heating, and coated with semiconductor layer that is adjusted by doping to desired resistance value |
DE102011077115A1 (en) * | 2011-06-07 | 2012-12-13 | Robert Bosch Gmbh | Cartridge, centrifuge and process |
CN102744163B (en) * | 2012-07-25 | 2013-08-21 | 安徽应流铸业有限公司 | Investment-pattern wax liquor filter unit and method for processing wax liquors by using same |
-
2012
- 2012-11-28 DE DE102012221734.7A patent/DE102012221734A1/en not_active Withdrawn
-
2013
- 2013-11-21 EP EP13794898.0A patent/EP2925442B1/en not_active Not-in-force
- 2013-11-21 CN CN201380061883.0A patent/CN104797341A/en active Pending
- 2013-11-21 WO PCT/EP2013/074332 patent/WO2014082911A1/en active Application Filing
- 2013-11-21 US US14/647,889 patent/US20150298126A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO2014082911A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20150298126A1 (en) | 2015-10-22 |
DE102012221734A1 (en) | 2014-05-28 |
CN104797341A (en) | 2015-07-22 |
EP2925442B1 (en) | 2017-01-11 |
WO2014082911A1 (en) | 2014-06-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2532427B1 (en) | Cartridge, centrifuge and method | |
DE19859586C1 (en) | Thermal cycler device | |
DE102010003223B4 (en) | Device for insertion into a rotor of a centrifuge, centrifuge and method for fluidic coupling of cavities | |
EP2574402B1 (en) | Nozzle having cylinder with coding and control elements | |
EP2532426B1 (en) | Cartridge for insertion into a centrifuge, centrifuge and method | |
EP2350675B1 (en) | Automated analytical device comprising an automatic pipetting device and a measuring device for determining the position of the pipetting needle tip | |
EP2532428B1 (en) | Cartridge, centrifuge and method for mixing a first and a second component | |
EP3592463B1 (en) | Method for centrifugo-pneumatic switching of liquid | |
EP2535108B1 (en) | Microfluidic System and method of operating the system | |
DE202013104751U1 (en) | Proximity switch arrangement with ground layer | |
EP2925442B1 (en) | Cartridge with electrical slide contact as well as process | |
DE102004043060B4 (en) | injection molding machine | |
EP2163902B1 (en) | Method and metering device for metering a fluid into a receptacle channel of a testing element for bodily fluid analysis | |
EP2486387A1 (en) | Analysis device and method | |
DE102004017750A1 (en) | Array of heatable electrodes and chemical and biochemical analysis | |
WO2018011085A1 (en) | Handling of liquids using a fluid module having a fluid plane that is inclined with respect to a rotation plane | |
WO2000029109A1 (en) | Sample holder for serial analysis of liquid samples | |
EP3043909B1 (en) | Microfluidic analysis component and production method | |
EP2808083A1 (en) | Lid assembly for extending applications, and cartridge with a lid assembly | |
EP2859953A1 (en) | System, centrifugation unit, centrifuge and method for inductive power generation | |
LU502092B1 (en) | Centrifuge for rotating a sample carrier | |
DE102012218369B4 (en) | Process for connecting layered metal structures on a polymer and layered structure made from a polymer and layered metal structures with an integrated thermocouple | |
EP1404447B1 (en) | Analysis device | |
DE102011106029B4 (en) | Tool unit of a device for foaming and / or encapsulation of a workpiece and device for foaming and / or encapsulation of a workpiece | |
DE102014221412A1 (en) | Analysis unit for analyzing a fluid, analysis device, method for operating an analysis unit and method for producing an analysis unit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20150629 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
INTG | Intention to grant announced |
Effective date: 20160531 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 860767 Country of ref document: AT Kind code of ref document: T Effective date: 20170115 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 502013006102 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: MP Effective date: 20170111 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170411 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170511 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170412 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170511 Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170411 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 502013006102 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 5 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
26N | No opposition filed |
Effective date: 20171012 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20171130 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20171130 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20171121 |
|
REG | Reference to a national code |
Ref country code: BE Ref legal event code: MM Effective date: 20171130 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20171121 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20171130 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20131121 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 860767 Country of ref document: AT Kind code of ref document: T Effective date: 20181121 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20181121 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20191121 Year of fee payment: 7 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20191126 Year of fee payment: 7 Ref country code: DE Payment date: 20200124 Year of fee payment: 7 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20170111 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 502013006102 Country of ref document: DE |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20201121 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20201130 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20201121 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20210601 |