EP2913059A4 - Novel method for treating spinal cord injury using hmgb1 fragment - Google Patents
Novel method for treating spinal cord injury using hmgb1 fragmentInfo
- Publication number
- EP2913059A4 EP2913059A4 EP13849823.3A EP13849823A EP2913059A4 EP 2913059 A4 EP2913059 A4 EP 2913059A4 EP 13849823 A EP13849823 A EP 13849823A EP 2913059 A4 EP2913059 A4 EP 2913059A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- spinal cord
- novel method
- cord injury
- treating spinal
- hmgb1 fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 title 1
- 208000020431 spinal cord injury Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL13849823T PL2913059T3 (en) | 2012-10-25 | 2013-10-24 | Novel method for treating spinal cord injury using hmgb1 fragment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012235786 | 2012-10-25 | ||
PCT/JP2013/078759 WO2014065348A1 (en) | 2012-10-25 | 2013-10-24 | Novel method for treating spinal cord injury using hmgb1 fragment |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2913059A1 EP2913059A1 (en) | 2015-09-02 |
EP2913059A4 true EP2913059A4 (en) | 2016-03-30 |
EP2913059B1 EP2913059B1 (en) | 2018-04-11 |
Family
ID=50544721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13849823.3A Active EP2913059B1 (en) | 2012-10-25 | 2013-10-24 | Novel method for treating spinal cord injury using hmgb1 fragment |
Country Status (18)
Country | Link |
---|---|
US (1) | US9688733B2 (en) |
EP (1) | EP2913059B1 (en) |
JP (1) | JP6253590B2 (en) |
KR (1) | KR102146822B1 (en) |
CN (1) | CN104955470B (en) |
AU (1) | AU2013335685B2 (en) |
BR (1) | BR112015008745B1 (en) |
CA (1) | CA2889299C (en) |
DK (1) | DK2913059T3 (en) |
ES (1) | ES2673861T3 (en) |
HK (2) | HK1212888A1 (en) |
MX (1) | MX365899B (en) |
PL (1) | PL2913059T3 (en) |
RU (1) | RU2649069C2 (en) |
SG (1) | SG11201503215XA (en) |
TR (1) | TR201807769T4 (en) |
WO (1) | WO2014065348A1 (en) |
ZA (1) | ZA201502829B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102083962B (en) | 2008-04-30 | 2013-03-27 | 吉诺米克斯股份有限公司 | Method for collecting functional cells in vivo with high efficiency |
WO2012147470A1 (en) | 2011-04-26 | 2012-11-01 | 株式会社ジェノミックス | Peptide for inducing regeneration of tissue and use thereof |
AU2013335684B2 (en) | 2012-10-25 | 2017-06-29 | Osaka University | Novel method for treating cardiac infarction using HMGB1 fragment |
EP3718561A4 (en) | 2017-12-01 | 2021-07-21 | Stemrim Inc. | Therapeutic agent for inflammatory bowel disease |
EP3750553A4 (en) | 2018-02-08 | 2022-01-12 | Stemrim Inc. | Therapeutic agent for psoriasis |
US20220009976A1 (en) * | 2018-10-05 | 2022-01-13 | StemRIM Inc. | Peptide Possessing Mesenchymal-Stem-Cell Mobilizing Activity |
SG11202104015YA (en) * | 2018-10-25 | 2021-05-28 | Univ Osaka | Therapeutic agent for cartilage disorder |
Citations (1)
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---|---|---|---|---|
WO2004046345A2 (en) * | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Use of hmgb fragments as anti-inflammatory agents |
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JP3018313B2 (en) * | 1996-02-23 | 2000-03-13 | 雪印乳業株式会社 | Bone formation promotion and bone resorption inhibitor |
US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
ATE440602T1 (en) | 1999-07-28 | 2009-09-15 | Univ Leland Stanford Junior | NICOTINE RECEPTOR AGONISTS IN STEM CELLS AND PROGRESSOR CELL INDUCTION |
EP1114862A3 (en) | 1999-11-17 | 2003-08-06 | Switch Biotech Aktiengesellschaft | Use of polyeptides or their encoding nucleic acids for the diagnosis or treatment of skin diseases and their use in indentifying pharmacologically acitve substances |
KR20030032922A (en) | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | Simultaneous stimulation and concentration of cells |
JP3421741B2 (en) | 2000-05-18 | 2003-06-30 | 筑波大学長 | Artificial bone marrow, blood cell proliferation method |
US20040191246A1 (en) | 2003-02-26 | 2004-09-30 | Connelly Patrick R. | Process for in vivo treatment of specific biological targets in bodily fluid |
ITMI20010562A1 (en) | 2001-03-16 | 2002-09-16 | Marco E Bianchi | HMG1 PROTEIN INHIBITORS OR ANTAGONISTS FOR THE TREATMENT OF VASCULAR DISORDERS |
DE10121254A1 (en) | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | Functional assay on the activity of human MRP8/MRP14 heterodimer, for diagnosing and treating skin diseases, wounds or wound-healing disturbances with reduced quantity of the heterodimer, in particular a diabetic ulcer |
EP1390058A2 (en) | 2001-04-30 | 2004-02-25 | Switch Biotech Aktiengesellschaft | Mrp8/mrp14 heterodimer, or its individual components in combination, for treating and/or preventing skin diseases, wounds and/or wound-healing disturbances |
US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
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CA2491321A1 (en) | 2002-07-03 | 2004-01-15 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair |
US7553488B2 (en) | 2002-07-05 | 2009-06-30 | UNIVERSITé LAVAL | Antibodies against S100A8 and S100A9 proteins for modulating inflammatory reactions |
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KR100593397B1 (en) | 2004-10-27 | 2006-06-28 | 한국원자력연구소 | Wound healing or wound healing promoters containing mesodermal stem cells and / or P substances, or cell therapeutics |
WO2006047820A1 (en) | 2004-11-01 | 2006-05-11 | Newsouth Innovations Pty Limited | Use of calgranulin a and b in the promotion and inhibition of mineralized tissue formation |
ITRM20050032A1 (en) | 2005-01-21 | 2006-07-22 | Marco E Bianchi | INHIBITORS AND ANTAGONISTS OF HMGB1 ABLE TO INHIBIT PATHOGENESIS AND PROGRESSION OF ATEROSCLEROTIC DISEASE. |
US9782439B2 (en) | 2005-01-27 | 2017-10-10 | Japan Health Sciences Foundation | Cell sheet containing mesenchymal stem cells |
WO2006100651A1 (en) | 2005-03-23 | 2006-09-28 | Biosafe S.A. | Integrated system for collecting, processing and transplanting cell subsets, including adult stem cells, for regenerative medicine |
WO2006114805A2 (en) | 2005-04-28 | 2006-11-02 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb2 and hmgb3 proteins for medical applications |
WO2007015546A1 (en) | 2005-08-04 | 2007-02-08 | Genomix Co., Ltd | Mesenchymal stem cell inducer, tissue regeneration promoter and method of preparing mesenchymal stem cell |
WO2007031100A1 (en) | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
WO2007130725A2 (en) | 2006-02-06 | 2007-11-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of hmgb1 for protection against ischemia reperfusion injury |
JP4982739B2 (en) | 2006-06-01 | 2012-07-25 | 国立大学法人 東京医科歯科大学 | Preventive and therapeutic agent for polyglutamine disease |
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CN101374538A (en) | 2006-10-30 | 2009-02-25 | 吉诺米克斯股份有限公司 | Pharmaceutical for promoting functional regeneration of damaged tissue |
CA2722852A1 (en) | 2008-04-30 | 2009-11-05 | Genomix Co., Ltd. | Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation |
CA2722906A1 (en) | 2008-04-30 | 2009-11-05 | Genomix Co., Ltd. | Pharmaceutical agent for promoting the functional regeneration of damaged tissue |
CN102083962B (en) | 2008-04-30 | 2013-03-27 | 吉诺米克斯股份有限公司 | Method for collecting functional cells in vivo with high efficiency |
ES2609006T3 (en) * | 2009-10-16 | 2017-04-18 | Rutgers, The State University Of New Jersey | Procedure for treating chronic nerve tissue injury using a cell therapy strategy |
CN102711777B (en) | 2009-10-28 | 2015-04-15 | 吉诺米克斯股份有限公司 | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
WO2012147470A1 (en) | 2011-04-26 | 2012-11-01 | 株式会社ジェノミックス | Peptide for inducing regeneration of tissue and use thereof |
CN102443064A (en) | 2011-11-03 | 2012-05-09 | 刘誉 | Thrombin activity based chimeric peptide with double targeting effects and application thereof |
AU2013335684B2 (en) | 2012-10-25 | 2017-06-29 | Osaka University | Novel method for treating cardiac infarction using HMGB1 fragment |
-
2013
- 2013-10-24 MX MX2015005253A patent/MX365899B/en active IP Right Grant
- 2013-10-24 KR KR1020157013591A patent/KR102146822B1/en active IP Right Grant
- 2013-10-24 BR BR112015008745-0A patent/BR112015008745B1/en active IP Right Grant
- 2013-10-24 CA CA2889299A patent/CA2889299C/en active Active
- 2013-10-24 US US14/436,920 patent/US9688733B2/en active Active
- 2013-10-24 WO PCT/JP2013/078759 patent/WO2014065348A1/en active Application Filing
- 2013-10-24 EP EP13849823.3A patent/EP2913059B1/en active Active
- 2013-10-24 ES ES13849823.3T patent/ES2673861T3/en active Active
- 2013-10-24 RU RU2015119523A patent/RU2649069C2/en active
- 2013-10-24 DK DK13849823.3T patent/DK2913059T3/en active
- 2013-10-24 TR TR2018/07769T patent/TR201807769T4/en unknown
- 2013-10-24 SG SG11201503215XA patent/SG11201503215XA/en unknown
- 2013-10-24 AU AU2013335685A patent/AU2013335685B2/en active Active
- 2013-10-24 PL PL13849823T patent/PL2913059T3/en unknown
- 2013-10-24 CN CN201380067951.4A patent/CN104955470B/en active Active
- 2013-10-24 JP JP2014543335A patent/JP6253590B2/en active Active
-
2015
- 2015-04-24 ZA ZA2015/02829A patent/ZA201502829B/en unknown
-
2016
- 2016-01-25 HK HK16100783.3A patent/HK1212888A1/en unknown
- 2016-02-04 HK HK16101298.9A patent/HK1213201A1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004046345A2 (en) * | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Use of hmgb fragments as anti-inflammatory agents |
Non-Patent Citations (6)
Title |
---|
E. VENEREAU ET AL: "Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 209, no. 9, 6 August 2012 (2012-08-06), pages 1519 - 1528, XP055079967, DOI: 10.1084/jem.20120189 * |
KO-ICHI KAWAHARA: "HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review)", EXPERIMENTAL AND THERAPEUTIC MEDICINE, 30 June 2011 (2011-06-30), GR, XP055250190, ISSN: 1792-0981, DOI: 10.3892/etm.2011.310 * |
MUELLER S ET AL: "The double life of HMGB1 chromatin protein: Architectural factor and extracellular signal", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 20, no. 16, 15 August 2001 (2001-08-15), pages 4337 - 4340, XP002261324, ISSN: 0261-4189, DOI: 10.1093/EMBOJ/20.16.4337 * |
See also references of WO2014065348A1 * |
ULLOA L ET AL: "High-mobility group box 1 (HMGB1) protein: Friend and foe", CYTOKINE AND GROWTH FACTOR REVIEWS, ELSEVIER LTD, GB, vol. 17, no. 3, 1 June 2006 (2006-06-01), pages 189 - 201, XP024987979, ISSN: 1359-6101, [retrieved on 20060601], DOI: 10.1016/J.CYTOGFR.2006.01.003 * |
Y. DONG ET AL: "HMGB1 Protein Does Not Mediate the Inflammatory Response in Spontaneous Spinal Cord Regeneration: A HINT FOR CNS REGENERATION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 25, 6 May 2013 (2013-05-06), US, pages 18204 - 18218, XP055250183, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.463810 * |
Also Published As
Publication number | Publication date |
---|---|
ES2673861T3 (en) | 2018-06-26 |
JP6253590B2 (en) | 2017-12-27 |
CA2889299A1 (en) | 2014-05-01 |
CN104955470B (en) | 2017-06-16 |
US20150274792A1 (en) | 2015-10-01 |
AU2013335685B2 (en) | 2017-10-12 |
AU2013335685A1 (en) | 2015-05-14 |
EP2913059A1 (en) | 2015-09-02 |
US9688733B2 (en) | 2017-06-27 |
HK1212888A1 (en) | 2016-06-24 |
HK1213201A1 (en) | 2016-06-30 |
SG11201503215XA (en) | 2015-06-29 |
KR20150102957A (en) | 2015-09-09 |
EP2913059B1 (en) | 2018-04-11 |
BR112015008745B1 (en) | 2022-08-02 |
TR201807769T4 (en) | 2018-06-21 |
MX2015005253A (en) | 2015-10-29 |
RU2649069C2 (en) | 2018-04-02 |
DK2913059T3 (en) | 2018-06-25 |
CA2889299C (en) | 2023-02-14 |
MX365899B (en) | 2019-06-19 |
RU2015119523A (en) | 2016-12-20 |
BR112015008745A2 (en) | 2017-11-21 |
WO2014065348A1 (en) | 2014-05-01 |
PL2913059T3 (en) | 2018-09-28 |
KR102146822B1 (en) | 2020-08-21 |
JPWO2014065348A1 (en) | 2016-09-08 |
CN104955470A (en) | 2015-09-30 |
ZA201502829B (en) | 2020-11-25 |
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