EP2905230B1 - Medicine packaging machine for blister packs for individual patients - Google Patents

Medicine packaging machine for blister packs for individual patients Download PDF

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Publication number
EP2905230B1
EP2905230B1 EP14154292.8A EP14154292A EP2905230B1 EP 2905230 B1 EP2905230 B1 EP 2905230B1 EP 14154292 A EP14154292 A EP 14154292A EP 2905230 B1 EP2905230 B1 EP 2905230B1
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EP
European Patent Office
Prior art keywords
packaging
packaging film
film
packaging machine
filling point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP14154292.8A
Other languages
German (de)
French (fr)
Other versions
EP2905230A1 (en
Inventor
Pieter Blank
Ralf Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erik Sellschopp GmbH
Original Assignee
Erik Sellschopp GmbH
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Filing date
Publication date
Application filed by Erik Sellschopp GmbH filed Critical Erik Sellschopp GmbH
Priority to EP14154292.8A priority Critical patent/EP2905230B1/en
Publication of EP2905230A1 publication Critical patent/EP2905230A1/en
Application granted granted Critical
Publication of EP2905230B1 publication Critical patent/EP2905230B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/06Enclosing successive articles, or quantities of material, in a longitudinally-folded web, or in a web folded into a tube about the articles or quantities of material placed upon it
    • B65B9/067Enclosing successive articles, or quantities of material, in a longitudinally-folded web, or in a web folded into a tube about the articles or quantities of material placed upon it the web advancing continuously
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0076Medicament distribution means
    • A61J7/0084Medicament distribution means for multiple medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0463Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers for multiple patients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/06Enclosing successive articles, or quantities of material, in a longitudinally-folded web, or in a web folded into a tube about the articles or quantities of material placed upon it
    • B65B9/073Enclosing successive articles, or quantities of material, in a longitudinally-folded web, or in a web folded into a tube about the articles or quantities of material placed upon it the web having intermittent motion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00General identification or selection means
    • A61J2205/10Bar codes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00General identification or selection means
    • A61J2205/60General identification or selection means using magnetic or electronic identifications, e.g. chips, RFID, electronic tags

Definitions

  • the present invention relates to a packaging machine, a packaging method and a computer program product for patient-specific blistering.
  • pharmaceuticals or dietary supplements in solid dosage form in variable amount, shape and size in a common packaging, so-called blister pack, patient-specific and in portions are packaged.
  • the patient receives a prescribed medication by the doctor with individual dosage, labeling and coding for a specific day and time.
  • EP2656829A1 relates to a tablet dispenser that allows easy cleaning of the inner surfaces of temporary storage structures.
  • a concurrent drive mechanism and a plurality of open-close mechanisms of a plurality of temporary memory structures are coupled together by a plurality of coupling structures.
  • the coupling structures are each arranged to release the coupling when the entire cache structure or a portion including the open-close mechanism of the cache structure is pulled out of a housing and to establish the coupling when the entire cache structure or the portion comprising the open-close mechanism is pushed into the housing of the cache structure.
  • US 5,671,592 A describes a medicine packaging apparatus containing medicine storage shelves for storing a large number of medicine containers having medicine contained therein, and a comparatively small number of medicine delivery devices used on each of the large number of medicine containers for supplying medicine in an amount according to a prescription.
  • the object of the present invention is therefore to provide an improved tablet packaging machine, an improved tablet packaging method and an improved computer program product which avoid or at least reduce the risk of cross-contamination. This object is achieved by the present invention.
  • a first embodiment of the invention relates to a packaging machine for packaging medicaments in solid dosage form for patient-specific blistering, according to claim 1.
  • the filling point may be located approximately at the bottom of a dosing tray from which, for example, tablets are emptied into a receptacle.
  • a receptacle may for example be a blister bag, wherein the blister bag is made from a packaging film.
  • the blister bag is closed after filling, for example, welded.
  • the packaging film is shaped such that it assumes, for example, a funnel shape. in this respect is here spoken of a funnel, it is merely meant a form that ensures the correct emptying of the dosing tray so that a failure of the packaging film is avoided when opening the bottom of the dosing tray.
  • the invention thus avoids or reduces the occurrence of cross-contamination, since the tablets pass directly from the dosing tray into the packaging film.
  • the invention also reduces errors in the selection and dosage of drugs as well as failures in drug intake.
  • the first embodiment has the folding unit on a first beak and a second beak for folding the packaging film. By using such beaks wrinkling of the packaging film can be avoided. This is achieved by forming a center fold of the packaging film during closing slowly. In this way, discarding or arbitrary folding or wrinkling of the packaging film is avoided.
  • the first and second beaks are each arranged at an angle to the direction of travel of the packaging film provided by the film transport unit.
  • the first and second beaks are arranged relative to each other such that they are arranged to guide the packaging film.
  • the first and second beaks are arranged relative to each other such that they are arranged to fold the packaging film towards the filling point.
  • a funnel-like design of the packaging film is achieved.
  • the packaging film accordingly has a wide opening, whereas the opening of the packaging film becomes narrower for folding. For a facilitated filling of the packaging film is achieved and incorrect emptying of the dosing tray can be avoided.
  • the first and second beaks are movably mounted.
  • the formation of the packaging film can be further supported and arbitrary folding is avoided.
  • the first and the second beak are arranged such that, at a first time before closing the packaging film, they have an opening angle of 1 ° to 90 °, preferably 5 ° to 60 °, more preferably 10 ° to 45 °, more preferably form substantially 30 °. This ensures that the folding of the packaging film is gentle. Thus, wrinkles or warping of the packaging film can be avoided.
  • the vertex of the opening angle of the first and second beak of the fold line of the packaging film is opposite. This arrangement of the beaks ensures that the packaging film is first closed at the upper end of the V-shaped opening and only at the last moment at the lower end. There is thus no discarding or arbitrary folding or wrinkling of the packaging film along the center fold.
  • the first and the second beak are arranged such that they form an opening angle of substantially 0 ° at a second time before closing the packaging film, the second time being after the first time. This ensures that the beaks cause the folding of the packaging film gently, since the opening angle between the beaks is reduced before the packaging film is sealed. Thus, wrinkles or warping of the packaging film can be avoided.
  • the closing unit has a welding unit for welding the packaging film in the form of a blister bag.
  • a welding unit for welding the packaging film in the form of a blister bag.
  • the welding unit is at an angle of substantially 90 ° to the intended running direction of the packaging film.
  • the welding unit is set up to form a welding line arranged essentially at right angles to the running direction of the packaging film.
  • the welding unit has a plurality of welding jaws.
  • the first and the second beak are arranged such that they are carried by the plurality of welding jaws.
  • the entrainment of the beaks on the welding jaws ensures that the closing process is coupled with the folding process in such a way that wrinkling of the film can be avoided. Because the entrained beaks lead and fold the packaging film before it is then welded by the welding jaws.
  • the first beak is preferably carried by a first welding jaw and the second beak by a second welding jaw.
  • the closing unit is set up to close the packaging film along a closing line.
  • the folding unit is arranged to fold the film along a folding line.
  • the packaging film, the closure line and the fold line together form a funnel, the funnel facing the filling point.
  • the packaging machine further comprises a dosing tray, wherein the dosing tray and the filling point are movable relative to each other. It is thereby achieved that, for example, a pharmacist or caregiver can prepare the medication in the dosage tray for a certain period of time (e.g., for one week) before the dosage tray is then placed in the packaging machine for filling the blister bags.
  • the dosing tray and the filling point are movable relative to each other in a substantially horizontally oriented plane.
  • the respective compartment of the dosing tray can be moved above the filling point.
  • the underside of the compartment can be opened to empty stored therein tablets in a below the filling point blister bag.
  • the filling point is stationary and the Dosiertablett relative to the filling point, preferably in a substantially horizontally oriented plane, movable.
  • the dosing tray further comprises an identifier, preferably an RFID transponder and / or a barcode, wherein the identifier is set up to store patient-specific information.
  • the packaging film or the blister bag also has an identifier.
  • the packaging machine has an identifier check unit which compares the identifier of dosing tray and packaging film with each other and outputs a match signal based on the result of the comparison. In this way, for example, the operation of the packaging machine can be stopped if the identifiers do not match. A faulty filling of blisters is thus avoided.
  • the packaging machine further comprises a printing unit for printing the packaging film with patient-specific information.
  • patient-specific information is, for example, the name of the patient and the period of taking or similar metadata useful to the patient. More preferably, these data are encrypted in a machine-readable code. In this way, for example, the recording of the intake times in an electronic calendar can be simplified.
  • a second embodiment of the invention relates to a packaging method for packaging medicaments in a solid administration form for patient-individual blistering according to claim 11.
  • a third embodiment of the invention relates to a computer program product which is set up to cause a packaging machine according to the invention to carry out the packaging method according to the invention.
  • the packaging machine of claim 1, the packaging method of claim 11 and the computer program product of claim 12 have similar and / or identical preferred embodiments.
  • a preferred embodiment of the invention may also be a combination of the dependent claims or the above-mentioned embodiments with the corresponding independent claim.
  • finished medicinal products are usually repackaged in blister bags. All medicines given at a time of administration are typically blistered in a pouch. If the blister bag becomes too full, two or more bags can be used for a single administration.
  • a packaging machine for patient-specific blistering comprises, for example, an FTP (File Transfer Protocol) server, a presentation module and a packaging module.
  • FTP File Transfer Protocol
  • the FTP server collects the patient data and the recipe and controls the data for the presentation and packaging module. These data are transmitted via the network to the pre-module and the packaging module. This happens, for example, by providing a shared drive, access the Vorstellmodul and packaging module.
  • the data format is XML, for example.
  • the presentation module preferably comprises a control unit, for example a computer. The control unit controls packaging orders and gives instructions to the user (for example, graphic instructions) during order processing.
  • a dosing tray or tray (see Fig. 1 to 5 ) be equipped by the user with various drugs in solid dosage form.
  • the control unit of the Vorstellmoduls gives the user instructions for sorting the drugs in the dosing tray compartments. These instructions can be done on a screen by way of graphical representation and on the respective dispenser tray by optical LED lighting.
  • the dosing tray preferably has an RFID chip (see Fig. 1 ), whereby the concrete packaging order can be assigned to the respective dosing tray.
  • Some or all of the metadata can be transmitted to the packaging module after completion of the sorting via a network connection.
  • the invention uses a new mode of operation in the packaging module in order to avoid cross-contamination.
  • a second (mechanical) part of the blistering process begins by placing the drug-filled dosing tray in the packaging module.
  • An optional RFID chip clearly identifies the dosing tray and the packaging order, and the packaging process can begin.
  • a stepper motor drive provides two-coordinate navigation of the dosing tray in the XY direction.
  • two fixed motors are installed, which move the dosing tray by turning in the same direction or in opposite directions by means of, for example, a toothed belt system via pulleys in the x- or ⁇ -direction and thus lead to a filling point.
  • the filling point is optionally configured stationary.
  • the bottom of a compartment is opened, for example with the aid of an optional lever below the dosing tray (see Fig. 5 ).
  • the bottom of a dosing tray compartment consists for example of a special spring steel. From the individual compartments of the dosing tray then successively fall the drug in each blister bag.
  • the blister bags are individually printed with patient data, medication, time of administration and drug information.
  • the drug to be packaged enters the packaging directly and without any contact from machine parts or funnels.
  • This is made possible by the skillful folding of the packaging film in combination with a step-wise welding technique of the film to individual bags (see Figures 7-9 ).
  • the packaging film is folded in a funnel shape at a preferably fixed location below the individual compartments of the dosing tray and thus replaces funnels or other machine parts [see Fig. 7 ). There is thus no possibility of undesirable cross-contamination within the packaging machine according to the invention.
  • the packaging film reaches its funnel shape through the use of two beaks (see Fig. 6-9 ), which support the lateral alignment of the film. After the medicines have entered the blister bag, the beaks help to tighten the foil and allow a smooth and wrinkle-free sealing of the individual bags (see Fig. 7-9 ). Contamination of the contents of the package is therefore also not possible later.
  • Fig. 1 shows by way of example and by way of example a metering tray 100 with optional identifier 110.
  • Identifier 110 may be, for example, an RFID chip.
  • Fig. 1 At the top left, a view of the dosage tray 100 is shown from above. The large illustration shows a view of the dosing tray 100 from below. In particular, the trays 105 of the dosing tray compartments can be seen.
  • Floor 105 is made of spring steel, for example, but any other elastic material is suitable, provided that it meets the hygiene requirements for patient-specific blinding.
  • Fig. 2 shows by way of example and by way of example a plan view of dosing tray 100.
  • dosing tray 100 has forty-two compartments arranged in six rows and seven columns.
  • other numbers of subjects are possible.
  • another arrangement of the individual subjects to each other is conceivable.
  • the matrix shown is merely a preferred variant.
  • identifier 110 which may be here, for example, an RFID chip.
  • Fig. 3 2 shows, by way of example and by way of example, a bottom view of the dosing tray 100 with the bottom 105 of a dosing tray compartment open downwardly to allow emptying of tablets from this dosing tray compartment.
  • This in Fig. 3 is merely one example of possible dosing mechanisms of the dosing tray compartments. It is also conceivable, for example, a slide-on mechanism, which pushes the bottom 105 to the side to allow falling out of the tablets.
  • the bottom 105 of spring steel is merely a preferred embodiment.
  • FIGS. 4 and 5 show by way of example and by way of example a detailed view of the dosing tray 100 when emptying tablets 441 of a dosing tray through dosing tray shelf 105. Also shown are tablets 442 in another dosing tray, the bottom of which is closed. In the example shown, bottom 105 is preferably opened only when the dosing tray compartment is located above the filling point, in order to allow a precise emptying of the tablets 441 in a blister bag.
  • Fig. 6 shows by way of example and by way of example a detailed view of the packaging machine 700 according to the invention (see Fig. 7 ).
  • the dosing tray 100 inserted into the packaging machine 700 can be seen.
  • the bottom 105 of a dosing tray compartment is opened in order to allow the contents of the dosing tray compartment into a funnel formed by the packaging film 650.
  • Packaging film 650 is through Foil transport unit 640 guided below the filling point 630 along.
  • Packaging film 650 is provided for forming blister bags.
  • Fig. 7 shows by way of example and by way of example a side view of a part of the packaging machine 700 according to the invention, which is located below the filling point 630.
  • Packaging film 650 is guided along the filling point 630 by means of the film transport unit 640. After filling with tablets 441, the packaging film 650 is placed in blister bags 810a, 810b, 801c, 801d (see Fig. 8 ) welded.
  • Fig. 8 shows by way of example and by way of example a detail side view of the packaging machine 700 according to the invention below the filling point 630. Shown is folding unit 820 (which in this example comprises first and second beak 820a, 820b, cf. Fig. 9 ) and sealing unit 830 (which in this example comprises a welding unit comprising welding jaws 830a, 830b, cf. Fig. 9 ).
  • the beaks 820a, 820b are arranged so that the film is bent down to the fold line.
  • the packaging film 650 is placed in blister bags 810a, 810b, 801c, 801d (see Fig. 8 ) welded. To close the beaks 820a, 820b before welding the packaging film 650 by the welding jaws 830a, 830b to an opening angle of 0 ° (see. Figures 10A-10E ).
  • Fig. 9 shows by way of example and by way of example a further detail side view of the packaging machine 700 according to the invention below the filling point 630.
  • the arrow indicates the direction of wrapping film 650.
  • the beaks 820a, 820b have an opening angle greater than 0 °.
  • welding jaws 830a and 830b are also shown.
  • the welding jaws 830a, 830b guide the beaks 820a, 820b.
  • FIGS. 10A-10E show by way of example and by way of example detailed views of the relative positions of beaks 820a, 820b, brake shoes 830a, 830b and packaging film 650 according to the inventive packaging method 1100 (see Fig. 11 ).
  • the opening angle of the beaks 820a, 820b decreases in accordance with the distance of the welding jaws 830a, 830b.
  • both beaks 820a, 820b lie directly against each other (opening angle 0 °) in order to enable a trouble-free welding by welding jaws 830a and 830b.
  • the special movement of Beak 820a, 820b allows wrinkle-free folding of the packaging film 650, thus avoiding subsequent contamination.
  • Fig. 11 shows by way of example and by way of example the packaging method 1100 according to the invention for packaging medicaments 441, 442 in solid dosage form for patient-specific blistering.
  • the packaging process 1100 includes the steps of: passing 1110 a packaging film 650 below a filling point 630, the packaging film 650 being for forming blister bags 810a, 810b, 810c, 810d; Folds 1120 of packaging film 650 toward filling point 630; and closing 1130 the packaging film 650 in the form of a blister bag 810a, 810b, 810c, 810d.
  • An example of an application of the packaging machine according to the invention, the packaging method according to the invention and the computer program product according to the invention relates in particular to the patient-specific blistering of medicaments.
  • the invention finds use, for example, in pharmacies, nursing homes or hospitals.
  • the folding process of the packaging film is achieved in particular by the use of two so-called beaks, these are merely preferred embodiments.
  • Other embodiments may involve the use of more than two beaks.
  • Further other embodiments may include specially designed brake shoes, which take over the folding of the packaging film.
  • a computer program product may be stored or distributed on a suitable medium, such as an optical storage medium or a solid state medium, which is co-distributed with or as part of other hardware.
  • a suitable medium such as an optical storage medium or a solid state medium, which is co-distributed with or as part of other hardware.
  • the computer program may also be distributed in other forms, e.g. over the internet or other telecommunication systems (including wireless networks).
  • the invention relates to a packaging machine, a packaging method and a computer program product new packaging method with a newly developed packaging machine for patient-specific blistering.
  • the packaging machine has a filling point at which blister bags can be filled, a film transport unit for guiding a packaging film below the filling point, the packaging film being provided for forming blister bags; a folding unit for folding the packaging film; and a closing unit for closing the packaging film in the form of a blister bag; wherein the folding unit is arranged to fold the packaging film towards the filling point.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Medical Informatics (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)

Description

Die vorliegende Erfindung betrifft eine Verpackungsmaschine, ein Verpackungsverfahren und ein Computerprogrammprodukt zur patientenindividuellen Verblisterung. Damit können Arzneimittel oder Nahrungsergänzungsmittel in fester Darreichungsform (Tabletten, Kapseln, Dragees) in variabler Menge, Form und Größe in eine gemeinsame Verpackung, sog. Blisterbeutel, patientenindividuell und portionsweise verpackt werden. Der Patient erhält so eine vom Arzt vorgegebene Medikation mit individueller Dosierung, Beschriftung und Codierung für einen bestimmten Tag und Zeitpunkt.The present invention relates to a packaging machine, a packaging method and a computer program product for patient-specific blistering. Thus, pharmaceuticals or dietary supplements in solid dosage form (tablets, capsules, dragees) in variable amount, shape and size in a common packaging, so-called blister pack, patient-specific and in portions are packaged. The patient receives a prescribed medication by the doctor with individual dosage, labeling and coding for a specific day and time.

EP2656829A1 betrifft eine Tablettenspendevorrichtung, die eine einfache Reinigung der Innenflächen von Zwischenspeicherstrukturen ermöglicht. Eine gleichzeitiger Antriebsmechanismus und eine Mehrzahl von Öffnen-Schließen-Mechanismen einer Mehrzahl von temporären Speicherstrukturen sind miteinander durch eine Mehrzahl von Kopplungsstrukturen gekoppelt. Die Kopplungsstrukturen sind jeweils eingerichtet, um die Kopplung zu lösen, wenn die gesamte Zwischenspeicherstruktur oder ein Abschnitt, der den Öffnen-Schließen-Mechanismus umfasst, der Zwischenspeicherstruktur aus einem Gehäuse gezogen wird, und um die Kopplung herzustellen, wenn die gesamte Zwischenspeicherstruktur oder der Abschnitt, der den Öffnen-Schließen-Mechanismus umfasst, der Zwischenspeicherstruktur in das Gehäuse geschoben wird. EP2656829A1 relates to a tablet dispenser that allows easy cleaning of the inner surfaces of temporary storage structures. A concurrent drive mechanism and a plurality of open-close mechanisms of a plurality of temporary memory structures are coupled together by a plurality of coupling structures. The coupling structures are each arranged to release the coupling when the entire cache structure or a portion including the open-close mechanism of the cache structure is pulled out of a housing and to establish the coupling when the entire cache structure or the portion comprising the open-close mechanism is pushed into the housing of the cache structure.

US 5,671,592 A beschreibt eine Medizinverpackungsvorrichtung, die Medizinlagerregale zur Lagerung einer großen Anzahl von Medizinbehältern enthält, die darin enthaltene Medizin aufweisen und eine vergleichsweise geringe Anzahl von Medizinzuführeinrichtungen von denen an jedem einer der großen Anzahl von Medizinbehältern eingesetzt wird, um Medizin in einer Menge gemäß einer Verschreibung zuzuführen. US 5,671,592 A describes a medicine packaging apparatus containing medicine storage shelves for storing a large number of medicine containers having medicine contained therein, and a comparatively small number of medicine delivery devices used on each of the large number of medicine containers for supplying medicine in an amount according to a prescription.

Typischerweise werden in bekannten Tablettenverpackungsmaschinen unterschiedliche Arzneimittel während des Verpackungsvorgangs über einen gemeinsamen Kontakt mit Maschinenteilen und eine gemeinsame Zuführung in die Verpackung geleitet. Beim Zuführen der Arzneimittel kann es zum Abrieb, zu Stäuben und im schlimmsten Fall zum Abplatzen oder Bruch einzelner Tablettenfragmente kommen Damit besteht die Gefahr von Kreuzkontaminationen, die beim Verblistern von Arzneimitteln zu vermeiden sind. In einem derartigen Verpackungsprozess können somit Spuren eines Arzneimittels auf dieselbe Position des Maschinenteils oder der Trichteroberfläche gelangen, wie zuvor bei einem anderen Arzneimittel. Abrieb, Staub oder abgeplatzte Tablettenfragmente können miteinander wechselwirken, wodurch ein Arzneimittel in der Wirkung durch ein anderes Arzneimittel gehemmt oder beschleunigt (inhibiert/katalysiert) werden kann.Typically, in known tablet packaging machines, different drugs are directed during the packaging process via a common contact with machine parts and a common feed into the package. Drug delivery may result in abrasion, dusts and, in the worst case, chipping or breakage of individual tablet fragments. There is a risk of cross-contamination, which should be avoided when pharmaceutical drugs are bleached. In such a packaging process, therefore, traces of a drug can reach the same position of the machine part or the funnel surface, as before with another medicine. Abrasion, dust or chipped tablet fragments can interact with each other, whereby a drug can be inhibited or accelerated (inhibited / catalyzed) by another drug.

Es ist wünschenswert, die oben beschriebenen Nachteile bekannter Tablettenverpackungsmaschinen zu vermeiden. Aufgabe der vorliegenden Erfindung ist daher, eine verbesserte Tablettenverpackungsmaschine, ein verbessertes Tablettenverpackungsverfahren und ein verbessertes Computerprogrammprodukt bereitzustellen, die die Gefahr von Kreuzkontaminationen vermeiden oder zumindest verringern. Diese Aufgabe wird durch die vorliegende Erfindung gelöst.It is desirable to avoid the above-described disadvantages of known tablet packaging machines. The object of the present invention is therefore to provide an improved tablet packaging machine, an improved tablet packaging method and an improved computer program product which avoid or at least reduce the risk of cross-contamination. This object is achieved by the present invention.

Eine erste Ausführungsform der Erfindung betrifft eine Verpackungsmaschine zum Verpacken von Arzneimitteln in fester Darreichungsform zur patientenindividuellen Verblisterung, gemäß Anspruch 1.A first embodiment of the invention relates to a packaging machine for packaging medicaments in solid dosage form for patient-specific blistering, according to claim 1.

Der Befüllpunkt kann sich etwa an der Unterseite eines Dosiertabletts befinden, aus der beispielsweise Tabletten in ein Aufnahmebehältnis entleert werden. Ein solches Aufnahmebehältnis kann beispielsweise ein Blisterbeutel sein, wobei der Blisterbeutel aus einer Verpackungsfolie hergestellt ist. Der Blisterbeutel wird nach Befüllung verschlossen, beispielsweise verschweißt. Durch Einsatz der Falteinheit wird erreicht, dass die Verpackungsfolie derart geformt ist, dass sie beispielsweise eine Trichterform annimmt. Insoweit hier von einem Trichter gesprochen wird, ist damit lediglich eine Form gemeint, die das korrekte Entleeren des Dosiertablettes derart sicherstellt, dass ein Verfehlen der Verpackungsfolie beim Öffnen der Unterseite des Dosiertabletts vermieden wird. Dies kann beispielsweise durch eine Form erreicht werden, die nahe dem Dosiertabletts weit ist und zum Knick oder zur Faltungslinie hin eng wird. Nach Entleeren der zu verpackenden Darreichungsform (z.B. Tabletten) in die geformte Verpackungsfolie wird die Verpackungsfolie verschlossen. Vor diesem Hintergrund ist der Einsatz von zusätzlichen trichterförmigen Maschinenteilen als Einfüllhilfe nicht erforderlich. Die Erfindung vermeidet oder verringert damit das Auftreten von Kreuzkontamination, da die Tabletten direkt vom Dosiertablett in die Verpackungsfolie gelangen. Die Erfindung reduziert weiterhin Fehler bei der Auswahl und Dosierung von Arzneimittel sowie Versäumnisse bei der Arzneimitteleinnahme. Die erste Ausführungsform weist die Falteinheit einen ersten Schnabel und einen zweiten Schnabel zum Falten der Verpackungsfolie auf. Durch den Einsatz von derartigen Schnäbeln kann ein Knittern der Verpackungsfolie vermieden werden. Dies wird erreicht indem sich eine Mittelfalte der Verpackungsfolie während des Schließens langsam ausformt. Auf diese Weise wird ein Verwerfen oder willkürliches Falten oder Knittern der Verpackungsfolie vermieden.The filling point may be located approximately at the bottom of a dosing tray from which, for example, tablets are emptied into a receptacle. Such a receptacle may for example be a blister bag, wherein the blister bag is made from a packaging film. The blister bag is closed after filling, for example, welded. By using the folding unit is achieved that the packaging film is shaped such that it assumes, for example, a funnel shape. in this respect is here spoken of a funnel, it is merely meant a form that ensures the correct emptying of the dosing tray so that a failure of the packaging film is avoided when opening the bottom of the dosing tray. This can be achieved, for example, by a mold which is wide near the dosing tray and becomes narrow towards the kink or fold line. After emptying the dosage form to be packaged (eg tablets) in the shaped packaging film, the packaging film is sealed. Against this background, the use of additional funnel-shaped machine parts as a filling aid is not required. The invention thus avoids or reduces the occurrence of cross-contamination, since the tablets pass directly from the dosing tray into the packaging film. The invention also reduces errors in the selection and dosage of drugs as well as failures in drug intake. The first embodiment has the folding unit on a first beak and a second beak for folding the packaging film. By using such beaks wrinkling of the packaging film can be avoided. This is achieved by forming a center fold of the packaging film during closing slowly. In this way, discarding or arbitrary folding or wrinkling of the packaging film is avoided.

Gemäß der ersten Ausführungsform sind der erste und der zweite Schnabel jeweils in einem Winkel zur durch die Folientransporteinheit vorgesehenen Laufrichtung der Verpackungsfolie angeordnet. Gemäß einer weiteren bevorzugten Ausführungsform sind der erste und zweite Schnabel derart zueinander angeordnet, dass sie eingerichtet sind, um die Verpackungsfolie zu führen. Somit wird mit dieser bevorzugten Ausführungsform erreicht, dass die Schnäbel einerseits formgebend andererseits führend wirken. Damit kann auf weitere Führungselemente verzichtet werden und die gesamte Verpackungsmaschine kann kompakter und billiger produziert werden.According to the first embodiment, the first and second beaks are each arranged at an angle to the direction of travel of the packaging film provided by the film transport unit. According to a further preferred embodiment, the first and second beaks are arranged relative to each other such that they are arranged to guide the packaging film. Thus, it is achieved with this preferred embodiment that the beaks on the one hand shaping on the other hand lead acting. This can be dispensed with further guide elements and the entire packaging machine can be produced more compact and cheaper.

Gemäß einer bevorzugten Ausführungsform sind der erste und zweite Schnabel derart zueinander angeordnet, dass sie eingerichtet sind, um die Verpackungsfolie zum Befüllpunkt hin zu falten. Durch die Faltung zum Befüllpunkt hin wird eine trichterartige Ausbildung der Verpackungsfolie erreicht. In der Nähe des Befüllpunktes weist die Verpackungsfolie demnach eine weite Öffnung auf, wohingegen die Öffnung der Verpackungsfolie zur Faltung hin umso enger wird. Damit wird eine erleichterte Befüllung der Verpackungsfolie erreicht und Fehlentleerungen des Dosiertabletts werden vermieden.According to a preferred embodiment, the first and second beaks are arranged relative to each other such that they are arranged to fold the packaging film towards the filling point. By folding to the filling point out a funnel-like design of the packaging film is achieved. In the vicinity of the filling point, the packaging film accordingly has a wide opening, whereas the opening of the packaging film becomes narrower for folding. For a facilitated filling of the packaging film is achieved and incorrect emptying of the dosing tray can be avoided.

Gemäß einer weiteren bevorzugten Ausführungsform sind der erste und zweite Schnabel beweglich gelagert. Durch eine bewegliche Lagerung der Schnäbel kann die Formung der Verpackungsfolie weiter unterstützt werden und willkürliches Falten wird vermieden.According to a further preferred embodiment, the first and second beaks are movably mounted. By a movable storage of the beaks, the formation of the packaging film can be further supported and arbitrary folding is avoided.

Gemäß einer weiteren bevorzugten Ausführungsform sind der erste und der zweite Schnabel derart angeordnet, dass sie zu einem ersten Zeitpunkt vor dem Verschließen der Verpackungsfolie einen Öffnungswinkel von 1° bis 90°, bevorzugt 5° bis 60°, weiter bevorzugt 10° bis 45°, weiter bevorzugt im Wesentlichen 30° bilden. Damit wird erreicht, dass die Faltung der Verpackungsfolie behutsam erfolgt. Somit können Knittern oder Verwerfungen der Verpackungsfolie vermieden werden.According to a further preferred embodiment, the first and the second beak are arranged such that, at a first time before closing the packaging film, they have an opening angle of 1 ° to 90 °, preferably 5 ° to 60 °, more preferably 10 ° to 45 °, more preferably form substantially 30 °. This ensures that the folding of the packaging film is gentle. Thus, wrinkles or warping of the packaging film can be avoided.

Gemäß einer weiteren bevorzugten Ausführungsform liegt der Scheitelpunkt des Öffnungswinkels des ersten und zweiten Schnabels der Faltlinie der Verpackungsfolie gegenüber. Durch diese Anordnung der Schnäbel wird erreicht, dass sich die Verpackungsfolie zunächst am oberen Ende der V-förmigen Öffnung geschlossen und erst im letzten Moment am unteren Ende. Es kommt somit nicht zu einem Verwerfen oder willkürlichen Falten oder Knittern der Verpackungsfolie entlang der Mittelfalte.According to a further preferred embodiment, the vertex of the opening angle of the first and second beak of the fold line of the packaging film is opposite. This arrangement of the beaks ensures that the packaging film is first closed at the upper end of the V-shaped opening and only at the last moment at the lower end. There is thus no discarding or arbitrary folding or wrinkling of the packaging film along the center fold.

Gemäß einer weiteren bevorzugten Ausführungsform sind der erste und der zweite Schnabel derart angeordnet, dass sie zu einem zweiten Zeitpunkt vor dem Verschließen der Verpackungsfolie einen Öffnungswinkel von im Wesentlichen 0° bilden, wobei der zweite Zeitpunkt nach dem ersten Zeitpunkt liegt. Damit wird erreicht, dass die Schnäbel die Faltung der Verpackungsfolie behutsam bewirken, da der Öffnungswinkel zwischen den Schnäbeln verringert wird, bevor die Verpackungsfolie verschlossen wird. Somit können Knittern oder Verwerfungen der Verpackungsfolie vermieden werden.According to a further preferred embodiment, the first and the second beak are arranged such that they form an opening angle of substantially 0 ° at a second time before closing the packaging film, the second time being after the first time. This ensures that the beaks cause the folding of the packaging film gently, since the opening angle between the beaks is reduced before the packaging film is sealed. Thus, wrinkles or warping of the packaging film can be avoided.

Gemäß einer weiteren bevorzugten Ausführungsform weist die Verschließeinheit eine Verschweißeinheit zum Verschweißen der Verpackungsfolie in Form eines Blisterbeutels auf. Durch Verschweißen der Verpackungsfolie wird ein hygienisches Verschließen der Verpackungsfolie in einen Blisterbeutel erreicht.According to a further preferred embodiment, the closing unit has a welding unit for welding the packaging film in the form of a blister bag. By welding the packaging film a hygienic sealing of the packaging film is achieved in a blister bag.

Gemäß einer weiteren bevorzugten Ausführungsform steht die Verschweißeinheit in einem Winkel von im Wesentlichen 90° zur vorgesehenen Laufrichtung der Verpackungsfolie. Die Verschweißeinheit ist eingerichtet, eine im Wesentlichen rechtwinklig zur Laufrichtung der Verpackungsfolie angeordnete Schweißlinie auszuformen. Auf diese Weise ermöglicht die bevorzugte Ausführungsform das Ausbilden von rechtwinkligen Blisterbeuteln, deren Grundkante der Schweißlinie entspricht, und deren eine Seitenkante der Knick- bzw. Faltlinie der Verpackungsfolie entspricht.According to a further preferred embodiment, the welding unit is at an angle of substantially 90 ° to the intended running direction of the packaging film. The welding unit is set up to form a welding line arranged essentially at right angles to the running direction of the packaging film. In this way, the preferred embodiment allows the formation of rectangular Blisterbeuteln whose bottom edge corresponds to the weld line, and whose one side edge corresponds to the folding or folding line of the packaging film.

Gemäß einer weiteren bevorzugten Ausführungsform weist die Verschweißeinheit eine Mehrzahl von Schweißbacken auf. Dabei sind der erste und der zweite Schnabel derart angeordnet, dass sie von der Mehrzahl von Schweißbacken mitgeführt werden. Durch das Mitführen der Schnäbel an den Schweißbacken wird erreicht, dass der Verschließvorgang mit dem Faltvorgang derart gekoppelt ist, dass ein Knittern der Folie vermieden werden kann. Denn die mitgeführten Schnäbel führen und falten die Verpackungsfolie, bevor diese dann von den Schweißbacken verschweißt wird. Bevorzugt werden dabei der erste Schnabel von einer ersten Schweißbacke und der zweite Schnabel von einer zweiten Schweißbacke mitgeführt.According to a further preferred embodiment, the welding unit has a plurality of welding jaws. In this case, the first and the second beak are arranged such that they are carried by the plurality of welding jaws. The entrainment of the beaks on the welding jaws ensures that the closing process is coupled with the folding process in such a way that wrinkling of the film can be avoided. Because the entrained beaks lead and fold the packaging film before it is then welded by the welding jaws. In this case, the first beak is preferably carried by a first welding jaw and the second beak by a second welding jaw.

Gemäß einer weiteren bevorzugten Ausführungsform ist die Verschließeinheit eingerichtet, die Verpackungsfolie entlang einer Verschließlinie zu verschließen. Die Falteinheit ist eingerichtet, die Folie entlang einer Faltlinie zu falten. Die Verpackungsfolie, die Verschließlinie und die Faltlinie bilden gemeinsam einen Trichter, wobei der Trichter dem Befüllpunkt zugewandt ist. Durch die genannte Formung und Anordnung der gefalteten Verpackungsfolie wird der Befüllvorgang einerseits erleichtert, weil ein Verfehlen der Verpackungsfolie beim Öffnen der Dosiertablett-Unterseite vermieden wird. Andererseits kann gemäß der bevorzugten Ausführungsform auf den Einsatz von Trichtern oder ähnlichem verzichtet werden, die in bekannten Verpackungsmaschinen zusätzlich zwischen Dosiertablett und Blisterbeutel angeordnet sind. Durch den Verzicht auf herkömmliche Trichter wird wiederum das Risiko von Kreuzkontaminationen erheblich gesenkt.According to a further preferred embodiment, the closing unit is set up to close the packaging film along a closing line. The folding unit is arranged to fold the film along a folding line. The packaging film, the closure line and the fold line together form a funnel, the funnel facing the filling point. By means of the aforementioned shaping and arrangement of the folded packaging film, the filling process on the one hand is facilitated because a failure of the packaging film when opening the metering tray underside is avoided. On the other hand, according to the preferred embodiment can be dispensed with the use of funnels or the like, which are additionally arranged in known packaging machines between dosing tray and blister. By eliminating conventional funnels, the risk of cross-contamination is significantly reduced.

Gemäß einer weiteren bevorzugten Ausführungsform weist die Verpackungsmaschine ferner ein Dosiertablett auf, wobei das Dosiertablett und der Befüllpunkt relativ zueinander bewegbar sind. Damit wird erreicht, dass etwa ein Apotheker oder eine Pflegekraft die Medikation für einen bestimmten Zeitraum (z.B. für eine Woche) in dem Dosiertablett vorbereiten kann, bevor das Dosiertablett dann zur Befüllung der Blisterbeutel in die Verpackungsmaschine gesetzt wird.According to a further preferred embodiment, the packaging machine further comprises a dosing tray, wherein the dosing tray and the filling point are movable relative to each other. It is thereby achieved that, for example, a pharmacist or caregiver can prepare the medication in the dosage tray for a certain period of time (e.g., for one week) before the dosage tray is then placed in the packaging machine for filling the blister bags.

Gemäß einer weiteren bevorzugten Ausführungsform sind das Dosiertablett und der Befüllpunkt in einer im Wesentlichen horizontal ausgerichteten Ebene gegeneinander bewegbar. Durch diese Ausgestaltung wird erreicht, dass das jeweilige Fach des Dosiertabletts oberhalb des Befüllpunktes bewegt werden kann. Dort kann dann beispielsweise die Unterseite des Faches geöffnet werden, um darin gelagerte Tabletten in einen unterhalb des Befüllpunktes angeordneten Blisterbeutel zu entleeren. Gemäß einer weiteren bevorzugten Ausführungsform ist der Befüllpunkt ortsfest ausgebildet und das Dosiertablett relativ zu dem Befüllpunkt, bevorzugt in einer im Wesentlichen horizontal ausgerichteten Ebene, bewegbar.According to a further preferred embodiment, the dosing tray and the filling point are movable relative to each other in a substantially horizontally oriented plane. By this configuration it is achieved that the respective compartment of the dosing tray can be moved above the filling point. There, then, for example, the underside of the compartment can be opened to empty stored therein tablets in a below the filling point blister bag. According to a further preferred embodiment, the filling point is stationary and the Dosiertablett relative to the filling point, preferably in a substantially horizontally oriented plane, movable.

Gemäß einer weiteren bevorzugten Ausführungsform weist das Dosiertablett ferner eine Kennung, vorzugsweise einen RFID-Transponder und/oder einen Barcode, auf, wobei die Kennung eingerichtet ist, um patientenindividuelle Informationen zu speichern. Das Versehen des Dosiertabletts mit einer Kennung bewirkt eine erhöhte Sicherheit der Zuordnung von Medikation und Blisterbeutel. Bevorzugt weist die Verpackungsfolie bzw. der Blisterbeutel ebenfalls eine Kennung auf. Weiter bevorzugt weist die Verpackungsmaschine eine Kennungsprüfeinheit auf, die die Kennung von Dosiertablett und Verpackungsfolie miteinander vergleicht und, basierend auf dem Ergebnis des Vergleichs, ein Übereinstimmungssignal ausgibt. Auf diese Weise kann beispielsweise der Betrieb der Verpackungsmaschine gestoppt werden, wenn die Kennungen nicht übereinstimmen. Ein fehlerhaftes Befüllen von Blisterbeuteln wird somit vermieden.According to a further preferred embodiment, the dosing tray further comprises an identifier, preferably an RFID transponder and / or a barcode, wherein the identifier is set up to store patient-specific information. Providing the dosing tray with an identifier increases the reliability of the association between the medication and the blister bag. Preferably, the packaging film or the blister bag also has an identifier. Further preferably, the packaging machine has an identifier check unit which compares the identifier of dosing tray and packaging film with each other and outputs a match signal based on the result of the comparison. In this way, for example, the operation of the packaging machine can be stopped if the identifiers do not match. A faulty filling of blisters is thus avoided.

Gemäß einer weiteren bevorzugten Ausführungsform weist die Verpackungsmaschine ferner eine Bedruckeinheit zum Bedrucken der Verpackungsfolie mit patientenindividuellen Informationen auf. Bei den patientenindividuellen Informationen handelt es sich beispielsweise um den Namen des Patienten und den Einnahmezeitraum oder ähnliche für den Patienten nützliche Metadaten. Weiter bevorzugt sind diese Daten in einem maschinenlesbaren Code verschlüsselt. Auf diese Weise kann beispielsweise das Erfassen der Einnahmezeitpunkte in einem elektronischen Kalender vereinfacht werden.According to a further preferred embodiment, the packaging machine further comprises a printing unit for printing the packaging film with patient-specific information. The patient-specific information is, for example, the name of the patient and the period of taking or similar metadata useful to the patient. More preferably, these data are encrypted in a machine-readable code. In this way, for example, the recording of the intake times in an electronic calendar can be simplified.

Eine zweite Ausführungsform der Erfindung betrifft ein Verpackungsverfahren zum Verpacken von Arzneimitteln in fester Darreichungsform zur patientenindividuellen Verblisterung, gemäß Anspruch 11. Eine dritte Ausführungsform der Erfindung betrifft ein Computerprogrammprodukt welches eingerichtet ist, eine erfindungsgemäße Verpackungsmaschine zur Durchführung des erfindungsgemäßen Verpackungsverfahrens zu veranlassen.A second embodiment of the invention relates to a packaging method for packaging medicaments in a solid administration form for patient-individual blistering according to claim 11. A third embodiment of the invention relates to a computer program product which is set up to cause a packaging machine according to the invention to carry out the packaging method according to the invention.

Die Verpackungsmaschine nach Anspruch 1, das Verpackungsverfahren nach Anspruch 11 und das Computerprogrammprodukt nach Anspruch 12 haben ähnliche und/oder identische bevorzugte Ausführungsformen.The packaging machine of claim 1, the packaging method of claim 11 and the computer program product of claim 12 have similar and / or identical preferred embodiments.

Eine bevorzugte Ausführungsform der Erfindung kann ebenso eine Kombination der abhängigen Ansprüche oder oben genannten Ausführungsformen mit dem entsprechenden unabhängigen Anspruch sein.A preferred embodiment of the invention may also be a combination of the dependent claims or the above-mentioned embodiments with the corresponding independent claim.

Im Folgenden wird eine Ausführungsform der vorliegenden Erfindung anhand der Figuren beschrieben. In den Figuren sind gleiche bzw. funktionsgleiche Teile mit denselben Bezugszeichen bezeichnet. Es zeigt:

Fig. 1
die Unterseite eines Dosiertabletts;
Fig. 2
die Oberseite eines Dosiertabletts;
Fig.
3 die Unterseite eines Dosiertabletts, wobei ein Fach zur Tablettenaufnahme geöffnet ist;
Fig. 4
eine Detailansicht eines Dosiertabletts, wobei ein Fach zur Tablettenaufnahme geöffnet ist;
Fig. 5
eine weitere Detailansicht eines Dosiertabletts, wobei ein Fach zur Tablettenaufnahme geöffnet ist;
Fig. 6
eine Detailansicht der erfindungsgemäßen Verpackungsmaschine;
Fig. 7
eine Seitenansicht der erfindungsgemäßen Verpackungsmaschine unterhalb des Befüllpunktes;
Fig. 8
eine Detail-Seitenansicht der erfindungsgemäßen Verpackungsmaschine unterhalb des Befüllpunktes;
Fig. 9
eine weitere Detail-Seitenansicht der erfindungsgemäßen Verpackungsmaschine unterhalb des Befüllpunktes;
Figuren 10A-10E
Detailansichten der relativen Stellungen von Schnäbeln, Bremsbacken und Verpackungsfolie gemäß dem erfindungsgemäßen Verpackungsverfahren; und
Fig. 11
das erfindungsgemäße Verpackungsverfahren.
Hereinafter, an embodiment of the present invention will be described with reference to the drawings. In the figures, the same or functionally identical parts are designated by the same reference numerals. It shows:
Fig. 1
the bottom of a dosing tray;
Fig. 2
the top of a dosage tray;
FIG.
Figure 3 shows the underside of a dosing tray with a tray for receiving tablets opened;
Fig. 4
a detailed view of a dosing tray, wherein a tray for tablet receiving is open;
Fig. 5
a further detail view of a dosing tray, with a tray for tablet recording is open;
Fig. 6
a detailed view of the packaging machine according to the invention;
Fig. 7
a side view of the packaging machine according to the invention below the filling point;
Fig. 8
a detail side view of the packaging machine according to the invention below the filling point;
Fig. 9
a further detail side view of the packaging machine according to the invention below the filling point;
Figures 10A-10E
Detailed views of the relative positions of beaks, brake shoes and packaging film according to the packaging method according to the invention; and
Fig. 11
the packaging method according to the invention.

Im Bereich der patientenindividuellen Verblisterung werden üblicherweise Fertigarzneimittel in Blisterbeuteln neuverpackt. Alle Arzneimittel, welche zu einem Einnahmezeitpunkt einzunehmen sind, werden dabei typischerweise in einem Beutel verblistert. Falls der Blisterbeutel zu voll wird, können auch zwei oder mehr Beutel für einen Einnahmezeitpunkt verwendet werden.In the field of patient-specific blistering, finished medicinal products are usually repackaged in blister bags. All medicines given at a time of administration are typically blistered in a pouch. If the blister bag becomes too full, two or more bags can be used for a single administration.

Eine Verpackungsmaschine zur patientenindividuellen Verblisterung umfasst beispielsweise einen FTP-(File Transfer Protocol)-Server, ein Vorstellmodul und ein Verpackungsmodul. An einem Client-Rechner werden Daten des jeweiligen Patienten und die ärztlich verordnete Medikation eingegeben. Der FTP-Server dient dem Erfassen der Patientendaten und des Rezeptes und steuert die Daten für das Vorstell- und das Verpackungsmodul. Diese Daten werden über das Netzwerk an das Vorstellmodul und das Verpackungsmodul übertragen. Dies geschieht beispielsweise durch Bereitstellen eines freigegebenen Laufwerkes, auf das Vorstellmodul und Verpackungsmodul zugreifen. Das Datenformat ist beispielsweise XML. Das Vorstellmodul umfasst bevorzugt eine Steuereinheit, beispielsweise einen Computer. Die Steuereinheit steuert Verpackungsaufträge und gibt dem Anwender Anweisungen (beispielsweise grafische Anweisungen) bei der Auftragsabwicklung.A packaging machine for patient-specific blistering comprises, for example, an FTP (File Transfer Protocol) server, a presentation module and a packaging module. At a client computer data of the respective patient and the medically prescribed medication are entered. The FTP server collects the patient data and the recipe and controls the data for the presentation and packaging module. These data are transmitted via the network to the pre-module and the packaging module. This happens, for example, by providing a shared drive, access the Vorstellmodul and packaging module. The data format is XML, for example. The presentation module preferably comprises a control unit, for example a computer. The control unit controls packaging orders and gives instructions to the user (for example, graphic instructions) during order processing.

In einem ersten (manuellen) Teil des Verblisterprozesses werden spezifische Arzneimittelinformationen (Pharmazentralnummer, Chargennummer, Verfalldatum) in das Programm eingegeben. Dies geschieht durch manuelle Eingabe und/oder automatisch mit Hilfe eines 2-D Barcode- oder QR-Readers. Die Vorteile der automatischen Datenerfassung sind Fehlervermeidung, Zeitersparnis und die Prävention gegen Medikamentenpiraterie. Auf diese Weise werden eindeutige Beutelchargennummern generiert. Während der Bearbeitung eines Auftrags ist auch ein Chargenwechsel möglich. Die genaue Bestimmung der Charge hat hohe Wichtigkeit im Falle eines Chargenrückrufs eines Arzneimittels.In a first (manual) part of the blister process, specific drug information (pharmaceutical central number, lot number, expiry date) is entered into the program. This is done by manual input and / or automatically with the help of a 2-D barcode or QR reader. The benefits of automatic data collection are error prevention, time savings and prevention of drug piracy. In this way, unique bag lot numbers are generated. While processing an order, a batch change is also possible. The exact determination of the batch is of great importance in the case of a batch recall of a drug.

Auf dem Vorstellmodul kann ein Dosiertablett bzw. Tray (siehe Fig. 1 bis 5) vom Anwender mit verschiedenen Arzneimitteln in fester Darreichungsform bestückt werden. Die Steuereinheit des Vorstellmoduls gibt dem Anwender dabei Anweisungen zum Einsortieren der Medikamente in die Dosiertablettfächer. Diese Anweisungen können etwa auf einem Bildschirm durch grafische Darstellung und an dem jeweiligen Dosiertablettfach durch optische LED-Beleuchtung erfolgen.On the presentation module, a dosing tray or tray (see Fig. 1 to 5 ) be equipped by the user with various drugs in solid dosage form. The control unit of the Vorstellmoduls gives the user instructions for sorting the drugs in the dosing tray compartments. These instructions can be done on a screen by way of graphical representation and on the respective dispenser tray by optical LED lighting.

Das Dosiertablett weist bevorzugt einen RFID-Chip auf (siehe Fig. 1), womit der konkrete Verpackungsauftrag dem jeweiligen Dosiertablett zugeordnet werden kann. Ein Teil oder alle Metadaten (wie zum Beispiel die oben genannten spezifischen Medikamenteninformationen, wie Charge, Ablaufdatum, etc.) können nach Abschluss des Einsortierens über eine Netzwerkverbindung an das Verpackungsmodul übertragen werden.The dosing tray preferably has an RFID chip (see Fig. 1 ), whereby the concrete packaging order can be assigned to the respective dosing tray. Some or all of the metadata (such as the specific medication information above, such as batch, expiration date, etc.) can be transmitted to the packaging module after completion of the sorting via a network connection.

Gemäß einer bevorzugten Ausführungsform bedient sich die Erfindung im Verpackungsmodul einer neuen Funktionsweise, um eine Kreuzkontamination zu vermeiden. Ein zweiter (maschineller) Teil des Verblisterprozesses beginnt, indem das mit Arzneimitteln befüllte Dosiertablett in das Verpackungsmodul eingesetzt wird. Durch einen optionalen RFID-Chip werden Dosiertablett und Verpackungsauftrag eindeutig erkannt und der Verpackungsprozess kann beginnen. Nach dem Start sorgt beispielsweise ein Schrittmotorantrieb für eine Zweikoordinatennavigation des Dosiertabletts in XY-Richtung. Bevorzugt sind zwei ortsfeste Motoren verbaut, welche das Dosiertablett durch gleichsinniges oder gegenläufiges Drehen mittels beispielsweise eines Zahnriemen-Systems über Umlenkrollen in der x- oder γ-Richtung bewegen und damit zu einem Befüllpunkt führen. Der Befüllpunkt ist optional ortsfest ausgestaltet. Gemäß einer bevorzugten Ausführungsform wird beispielsweise mit Hilfe eines optionalen Hebels unterhalb des Dosiertabletts der Boden eines Faches geöffnet (siehe Fig. 5). Der Boden eines Dosiertablettfaches besteht beispielsweise aus einem speziellen Federstahl. Aus den einzelnen Fächern des Dosiertabletts fallen dann nacheinander die Arzneimittel in den jeweiligen Blisterbeutel. Optional werden die Blisterbeutel vorher jeweils mit den Patientendaten, Medikation, Einnahmezeitpunkt und Arzneimittelinformationen individuell bedruckt.According to a preferred embodiment, the invention uses a new mode of operation in the packaging module in order to avoid cross-contamination. A second (mechanical) part of the blistering process begins by placing the drug-filled dosing tray in the packaging module. An optional RFID chip clearly identifies the dosing tray and the packaging order, and the packaging process can begin. For example, after startup, a stepper motor drive provides two-coordinate navigation of the dosing tray in the XY direction. Preferably, two fixed motors are installed, which move the dosing tray by turning in the same direction or in opposite directions by means of, for example, a toothed belt system via pulleys in the x- or γ-direction and thus lead to a filling point. The filling point is optionally configured stationary. According to a preferred embodiment, the bottom of a compartment is opened, for example with the aid of an optional lever below the dosing tray (see Fig. 5 ). The bottom of a dosing tray compartment consists for example of a special spring steel. From the individual compartments of the dosing tray then successively fall the drug in each blister bag. Optionally, the blister bags are individually printed with patient data, medication, time of administration and drug information.

Das zu verpackende Arzneimittel gelangt beim Verpackungsprozess direkt und ohne Kontakt von Maschinenteilen oder Trichter in die Verpackung. Dies wird ermöglicht durch das geschickte Falten der Verpackungsfolie in Kombination mit einer schrittweisen Verschweißtechnik der Folie zu einzelnen Beuteln (siehe Figuren 7-9). Die Verpackungsfolie wird an einem vorzugsweise fixen Ort unterhalb der einzelnen Fächer des Dosiertabletts trichterförmig gefaltet und ersetzt somit Trichter oder anderweitige Maschinenteile [siehe Fig. 7). Es gibt damit keine Möglichkeit der unerwünschten Kreuzkontamination innerhalb der erfindungsgemäßen Verpackungsmaschine.In the packaging process, the drug to be packaged enters the packaging directly and without any contact from machine parts or funnels. This is made possible by the skillful folding of the packaging film in combination with a step-wise welding technique of the film to individual bags (see Figures 7-9 ). The packaging film is folded in a funnel shape at a preferably fixed location below the individual compartments of the dosing tray and thus replaces funnels or other machine parts [see Fig. 7 ). There is thus no possibility of undesirable cross-contamination within the packaging machine according to the invention.

Die Verpackungsfolie erreicht ihre Trichterform durch den Einsatz von zwei Schnäbeln (siehe Fig. 6-9), die das seitlichen Ausrichten der Folie unterstützen. Nachdem die Arzneimittel in den Blisterbeutel gelangt sind, helfen die Schnäbel beim Straffen der Folie und ermöglichen so ein glattes und faltenfreies Verschweißen der einzelnen Beutel (siehe Fig. 7-9). Eine Kontamination des Verpackungsinhalts ist somit auch nachträglich nicht möglich.The packaging film reaches its funnel shape through the use of two beaks (see Fig. 6-9 ), which support the lateral alignment of the film. After the medicines have entered the blister bag, the beaks help to tighten the foil and allow a smooth and wrinkle-free sealing of the individual bags (see Fig. 7-9 ). Contamination of the contents of the package is therefore also not possible later.

Fig. 1 zeigt beispielhaft und exemplarisch ein Dosiertablett 100 mit optionaler Kennung 110. Bei Kennung 110 kann es sich beispielsweise um einen RFID-Chip handeln. In Fig. 1 ist oben links eine Ansicht des Dosiertabletts 100 von oben gezeigt. Die große Darstellung zeigt eine Ansicht des Dosiertabletts 100 von unten. Dabei sind insbesondere die Böden 105 der Dosiertablettfächer zu erkennen. Boden 105 ist beispielsweise aus Federstahl hergestellt, allerdings ist jedes andere elastische Material geeignet, sofern es den Hygieneanforderungen beim patientenindividuellen Verblistern genügt. Fig. 1 shows by way of example and by way of example a metering tray 100 with optional identifier 110. Identifier 110 may be, for example, an RFID chip. In Fig. 1 At the top left, a view of the dosage tray 100 is shown from above. The large illustration shows a view of the dosing tray 100 from below. In particular, the trays 105 of the dosing tray compartments can be seen. Floor 105 is made of spring steel, for example, but any other elastic material is suitable, provided that it meets the hygiene requirements for patient-specific blinding.

Fig. 2 zeigt beispielhaft und exemplarisch eine Draufsicht auf Dosiertablett 100. In dem gezeigten Beispiel weist Dosiertablett 100 zweiundvierzig Fächer auf, die in sechs Zeilen und sieben Spalten angeordnet sind. Allerdings sind auch andere Zahlen von Fächern möglich. Ebenso ist eine andere Anordnung der einzelnen Fächer zueinander denkbar. Die in Fig. 2 gezeigte Matrix ist lediglich eine bevorzugte Variante. Ebenfalls in Fig. 2 gezeigt ist Kennung 110, die hier beispielsweise ein RFID-Chip sein kann. Fig. 2 shows by way of example and by way of example a plan view of dosing tray 100. In the example shown, dosing tray 100 has forty-two compartments arranged in six rows and seven columns. However, other numbers of subjects are possible. Likewise, another arrangement of the individual subjects to each other is conceivable. In the Fig. 2 The matrix shown is merely a preferred variant. Also in Fig. 2 shown is identifier 110, which may be here, for example, an RFID chip.

Fig. 3 zeigt beispielhaft und exemplarisch eine Ansicht des Dosiertabletts 100 von unten, bei dem Boden 105 eines Dosiertablettfaches nach unten geöffnet ist, um das Entleeren von Tabletten aus diesem Dosiertablettfach zu ermöglichen. Das in Fig. 3 gezeigte Beispiel ist jedoch lediglich ein Beispiel für mögliche Entleermechanismen der Dosiertablettfächer. Ebenso denkbar ist beispielsweise ein Aufschiebemechanismus, der den Boden 105 zur Seite schiebt, um das Herausfallen der Tabletten zu ermöglichen. Der Boden 105 aus Federstahl ist lediglich eine bevorzugte Ausführungsform. Fig. 3 2 shows, by way of example and by way of example, a bottom view of the dosing tray 100 with the bottom 105 of a dosing tray compartment open downwardly to allow emptying of tablets from this dosing tray compartment. This in Fig. 3 However, the example shown is merely one example of possible dosing mechanisms of the dosing tray compartments. It is also conceivable, for example, a slide-on mechanism, which pushes the bottom 105 to the side to allow falling out of the tablets. The bottom 105 of spring steel is merely a preferred embodiment.

Die Figuren 4 und 5 zeigen beispielhaft und exemplarisch eine Detailansicht des Dosiertabletts 100 beim Entleeren von Tabletten 441 eines Dosiertablettfachs über Dosiertablettfachboden 105. Ebenfalls gezeigt sind Tabletten 442 in einem weiteren Dosiertablettfach, dessen Boden geschlossen ist. In dem gezeigten Beispiel wird Boden 105 vorzugsweise erst dann geöffnet, wenn sich das Dosiertablettfach oberhalb des Befüllpunktes befindet, um ein zielgenaues Entleeren der Tabletten 441 in einen Blisterbeutel zu ermöglichen.The FIGS. 4 and 5 show by way of example and by way of example a detailed view of the dosing tray 100 when emptying tablets 441 of a dosing tray through dosing tray shelf 105. Also shown are tablets 442 in another dosing tray, the bottom of which is closed. In the example shown, bottom 105 is preferably opened only when the dosing tray compartment is located above the filling point, in order to allow a precise emptying of the tablets 441 in a blister bag.

Fig. 6 zeigt beispielhaft und exemplarisch eine Detailansicht der erfindungsgemäßen Verpackungsmaschine 700 (siehe Fig. 7). Zu erkennen ist das in die Verpackungsmaschine 700 eingesetzte Dosiertablett 100. An Befüllpunkt 630 ist Boden 105 eines Dosiertablettfachs geöffnet, um den Inhalt des Dosiertablettfachs in einen durch Verpackungsfolie 650 geformten Trichter zu ermöglichen. Verpackungsfolie 650 wird durch Folientransporteinheit 640 unterhalb des Befüllpunktes 630 entlang geführt. Verpackungsfolie 650 ist zum Bilden von Blisterbeuteln vorgesehen. Fig. 6 shows by way of example and by way of example a detailed view of the packaging machine 700 according to the invention (see Fig. 7 ). The dosing tray 100 inserted into the packaging machine 700 can be seen. At the filling point 630, the bottom 105 of a dosing tray compartment is opened in order to allow the contents of the dosing tray compartment into a funnel formed by the packaging film 650. Packaging film 650 is through Foil transport unit 640 guided below the filling point 630 along. Packaging film 650 is provided for forming blister bags.

Fig. 7 zeigt beispielhaft und exemplarisch eine Seitenansicht eines Teils der erfindungsgemäßen Verpackungsmaschine 700, der sich unterhalb des Befüllpunktes 630 befindet. Verpackungsfolie 650 wird mittels der Folientransporteinheit 640 am Befüllpunkt 630 entlang geführt. Nach dem Befüllen mit Tabletten 441 wird die Verpackungsfolie 650 in Blisterbeutel 810a, 810b, 801c, 801d (siehe Fig. 8) verschweißt. Fig. 7 shows by way of example and by way of example a side view of a part of the packaging machine 700 according to the invention, which is located below the filling point 630. Packaging film 650 is guided along the filling point 630 by means of the film transport unit 640. After filling with tablets 441, the packaging film 650 is placed in blister bags 810a, 810b, 801c, 801d (see Fig. 8 ) welded.

Fig. 8 zeigt beispielhaft und exemplarisch eine Detail-Seitenansicht der erfindungsgemäßen Verpackungsmaschine 700 unterhalb des Befüllpunktes 630. Gezeigt ist Falteinheit 820 (die in diesem Beispiel ersten und zweiten Schnabel 820a, 820b umfasst, vgl. Fig. 9) und Verschließeinheit 830 (die in diesem Beispiel eine Verschweißeinheit umfassend Schweißbacken 830a, 830b umfasst, vgl. Fig. 9). In dem Beispiel von Fig. 8 sind die Schnäbel 820a, 820b derart angeordnet, dass die Folie nach unten zur Faltlinie hin geknickt wird. Nach dem Befüllen mit Tabletten 441 wird die Verpackungsfolie 650 in Blisterbeutel 810a, 810b, 801c, 801d (siehe Fig. 8) verschweißt. Dazu schließen die Schnäbel 820a, 820b vor dem Verschweißen der Verpackungsfolie 650 durch die Schweißbacken 830a, 830b zu einem Öffnungswinkel von 0° (vgl. Figuren 10A-10E). Fig. 8 shows by way of example and by way of example a detail side view of the packaging machine 700 according to the invention below the filling point 630. Shown is folding unit 820 (which in this example comprises first and second beak 820a, 820b, cf. Fig. 9 ) and sealing unit 830 (which in this example comprises a welding unit comprising welding jaws 830a, 830b, cf. Fig. 9 ). In the example of Fig. 8 the beaks 820a, 820b are arranged so that the film is bent down to the fold line. After filling with tablets 441, the packaging film 650 is placed in blister bags 810a, 810b, 801c, 801d (see Fig. 8 ) welded. To close the beaks 820a, 820b before welding the packaging film 650 by the welding jaws 830a, 830b to an opening angle of 0 ° (see. Figures 10A-10E ).

Fig. 9 zeigt beispielhaft und exemplarisch eine weitere Detail-Seitenansicht der erfindungsgemäßen Verpackungsmaschine 700 unterhalb des Befüllpunktes 630. Dabei deutet der Pfeil die Laufrichtung von Verpackungsfolie 650 an. In der Darstellung von Fig. 9 weisen die Schnäbel 820a, 820b einen Öffnungswinkel größer 0° auf. Ebenso gezeigt sind Schweißbacken 830a und 830b. In dem bevorzugten Ausführungsbeispiel von Fig. 9 führen die Schweißbacken 830a, 830b die Schnäbel 820a, 820b mit. Allerdings ist es genauso möglich, die Schnäbel 820a, 820b unabhängig von den Schweißbacken 830a, 830b zu lagern und zu führen. Fig. 9 shows by way of example and by way of example a further detail side view of the packaging machine 700 according to the invention below the filling point 630. In this case, the arrow indicates the direction of wrapping film 650. In the presentation of Fig. 9 the beaks 820a, 820b have an opening angle greater than 0 °. Also shown are welding jaws 830a and 830b. In the preferred embodiment of Fig. 9 The welding jaws 830a, 830b guide the beaks 820a, 820b. However, it is equally possible to store and guide the beaks 820a, 820b independently of the welding jaws 830a, 830b.

Die Figuren 10A-10E zeigen beispielhaft und exemplarisch Detailansichten der relativen Stellungen von Schnäbeln 820a, 820b, Bremsbacken 830a, 830b und Verpackungsfolie 650 gemäß dem erfindungsgemäßen Verpackungsverfahren 1100 (siehe Fig. 11). In dem gezeigten Beispiel verkleinert sich der Öffnungswinkel der Schnäbel 820a, 820b entsprechend zum Abstand der Schweißbacken 830a, 830b. Schließlich liegen beide Schnäbel 820a, 820b direkt aufeinander (Öffnungswinkel 0°), um ein störungsfreies Verschweißen durch Schweißbacken 830a und 830b zu ermöglichen. Die besondere Bewegung der Schnäbel 820a, 820b ermöglicht ein knitterfreies Falten der Verpackungsfolie 650 und vermeidet so auch nachträgliche Kontamination.The Figures 10A-10E show by way of example and by way of example detailed views of the relative positions of beaks 820a, 820b, brake shoes 830a, 830b and packaging film 650 according to the inventive packaging method 1100 (see Fig. 11 ). In the example shown, the opening angle of the beaks 820a, 820b decreases in accordance with the distance of the welding jaws 830a, 830b. Finally, both beaks 820a, 820b lie directly against each other (opening angle 0 °) in order to enable a trouble-free welding by welding jaws 830a and 830b. The special movement of Beak 820a, 820b allows wrinkle-free folding of the packaging film 650, thus avoiding subsequent contamination.

Fig. 11 zeigt beispielhaft und exemplarisch das erfindungsgemäße Verpackungsverfahren 1100 zum Verpacken von Arzneimitteln 441, 442 in fester Darreichungsform zur patientenindividuellen Verblisterung. Das Verpackungsverfahren 1100 weist die folgenden Schritte auf: Führen 1110 einer Verpackungsfolie 650 unterhalb eines Befüllpunktes 630 entlang, wobei die Verpackungsfolie 650 zum Bilden von Blisterbeuteln 810a, 810b, 810c, 810d vorgesehen ist; Falten 1120 der Verpackungsfolie 650 zum Befüllpunkt 630 hin; und Verschließen 1130 der Verpackungsfolie 650 in Form eines Blisterbeutels 810a, 810b, 810c, 810d. Fig. 11 shows by way of example and by way of example the packaging method 1100 according to the invention for packaging medicaments 441, 442 in solid dosage form for patient-specific blistering. The packaging process 1100 includes the steps of: passing 1110 a packaging film 650 below a filling point 630, the packaging film 650 being for forming blister bags 810a, 810b, 810c, 810d; Folds 1120 of packaging film 650 toward filling point 630; and closing 1130 the packaging film 650 in the form of a blister bag 810a, 810b, 810c, 810d.

Ein Beispiel für eine Anwendung der erfindungsgemäßen Verpackungsmaschine, des erfindungsgemäßen Verpackungsverfahrens und des erfindungsgemäßen Computerprogrammproduktes betrifft insbesondere die patientenindividuelle Verblisterung von Medikamenten.An example of an application of the packaging machine according to the invention, the packaging method according to the invention and the computer program product according to the invention relates in particular to the patient-specific blistering of medicaments.

Die Erfindung findet beispielsweise Einsatz in Apotheken, Pflegestationen oder Krankenhäusern.The invention finds use, for example, in pharmacies, nursing homes or hospitals.

Wenngleich in den oben beschriebenen Ausführungsformen der Faltvorgang der Verpackungsfolie insbesondere durch den Einsatz von zwei sogenannten Schnäbeln erreicht wird, so handelt es sich hierbei lediglich um bevorzugte Ausführungsformen. Andere Ausführungsformen können den Einsatz von mehr als zwei Schnäbeln umfassen. Weiter andere Ausführungsformen können besonders gestaltete Bremsbacken umfassen, die die Faltung der Verpackungsfolie übernehmen.Although in the embodiments described above, the folding process of the packaging film is achieved in particular by the use of two so-called beaks, these are merely preferred embodiments. Other embodiments may involve the use of more than two beaks. Further other embodiments may include specially designed brake shoes, which take over the folding of the packaging film.

Der Fachmann erkennt andere Variationen der offenbarten Ausführungsformen zur Umsetzung der beschriebenen Erfindung aus den beigefügten Zeichnungen, der Beschreibung und den Ansprüchen.Those skilled in the art will recognize other variations of the disclosed embodiments for practicing the described invention from the accompanying drawings, the description, and the claims.

Der Ausdruck "umfassen" in den Ansprüchen schließt nicht aus, dass weitere Merkmale oder Verfahrensschritte vorhanden sind. Der unbestimmte Artikel "ein" oder "eine" schließt nicht aus, dass es sich um eine Mehrzahl handeln kann.The term "comprising" in the claims does not exclude that other features or process steps exist. The indefinite article "a" or "an" does not exclude that it may be a plurality.

Eine einzelne Einheit kann die Wirkungen mehrerer Elemente in den Ansprüchen übernehmen. Allein die Tatsache, dass bestimmte Merkmale oder Verfahrensschritte in unterschiedlichen abhängigen Ansprüchen definiert werden, bedeutet nicht, dass eine Kombination der genannten Merkmale oder Verfahrensschritte nicht auch eine synergistische Wirkung haben kann.A single entity can take over the effects of several elements in the claims. Alone the fact that certain characteristics or process steps in different dependent claims do not mean that a combination of said features or process steps can not also have a synergistic effect.

Ein Computerprogrammprodukt kann gespeichert oder auf einem geeigneten Medium verbreitet werden, wie etwa einem optischen Speichermedium oder einem Festkörpermedium, welches gemeinsam mit oder als Teil von anderer Hardware vertrieben wird. Das Computerprogramm kann aber ebenso in anderer Form vertrieben werden, wie z.B. über das Internet oder andere Telekommunikationssysteme (einschließlich drahtlose Netzwerke).A computer program product may be stored or distributed on a suitable medium, such as an optical storage medium or a solid state medium, which is co-distributed with or as part of other hardware. However, the computer program may also be distributed in other forms, e.g. over the internet or other telecommunication systems (including wireless networks).

Die Bezugszeichen in den Ansprüchen dürfen nicht zu einer einschränkenden Auslegung des Patentanspruchs herangezogen werden.The reference signs in the claims may not be used to a restrictive interpretation of the claim.

Die Erfindung betrifft eine Verpackungsmaschine, ein Verpackungsverfahren und ein Computerprogrammprodukt neues Verpackungsverfahren mit einer neu entwickelten Verpackungsmaschine zur patientenindividuellen Verblisterung. Die Verpackungsmaschine weist einen Befüllpunkt auf, an dem Blisterbeutel befüllt werden können, eine Folientransporteinheit zum Führen einer Verpackungsfolie unterhalb des Befüllpunktes entlang, wobei die Verpackungsfolie zum Bilden von Blisterbeuteln vorgesehen ist; eine Falteinheit zum Falten der Verpackungsfolie; und eine Verschließeinheit zum Verschließen der Verpackungsfolie in Form eines Blisterbeutels; wobei die Falteinheit eingerichtet ist, die Verpackungsfolie zum Befüllpunkt hin zu falten. Eine unerwünschte und zu vermeidende Kreuzkontamination wird durch das Weglassen eines konventionellen Trichters oder anderer Hilfsmittel, ebenso vermieden, wie eine unerwünschte Fehldosierung.The invention relates to a packaging machine, a packaging method and a computer program product new packaging method with a newly developed packaging machine for patient-specific blistering. The packaging machine has a filling point at which blister bags can be filled, a film transport unit for guiding a packaging film below the filling point, the packaging film being provided for forming blister bags; a folding unit for folding the packaging film; and a closing unit for closing the packaging film in the form of a blister bag; wherein the folding unit is arranged to fold the packaging film towards the filling point. An undesirable and avoidable cross contamination is avoided by omitting a conventional funnel or other aids, as well as an undesirable misdosing.

Claims (12)

  1. Packaging machine (700) for packaging medicines (441, 442) in solid dosage form into patient-specific blister packs, wherein the packaging machine (700) comprises:
    a filling point (630) at which blister packs (810a, 810b, 810c, 810d) can be filled;
    a film transport unit (640) for guiding a packaging film (650) along underneath the filling point (630), wherein the packaging film (650) is provided for forming blister packs (810a, 810b, 810c, 810d);
    a folding unit (820, 820a, 820b) for folding the packaging film (650);
    a closing unit (830, 830a, 830b) for closing the packaging film (650) in the form of a blister pack (810a, 810b, 810c, 810d); and
    wherein the folding unit (820, 820a, 820b) is adapted to fold the packaging film (650) back up to the filling point (630);
    characterised in that the folding unit (820, 820a, 820b) has a first beak (820a) and a second beak (820b) for folding the packaging film (650),
    wherein the first and second beak (820a, 820b) are each arranged at an angle to the running direction of the packaging film (650) provided by the film transport unit (640), and
    wherein the first and second beak (820a, 820b) are arranged relative to one another in such a way that they are set up to guide the packaging film (650).
  2. Packaging machine (700) according to Claim 1,
    wherein the first and second beak (820a, 820b) are arranged relative to one another in such a way that they fold the packaging film (650) towards the filling point (630).
  3. Packaging machine (700) according to any one of Claims 1 to 2,
    wherein the first and second beak (820a, 820b) are mounted rotatably.
  4. Packaging machine (700) according to any one of Claims 1 to 3,
    wherein the closing unit (830, 830a, 830b) comprises a welding unit for welding the packaging film (650) in the form of a blister pack (810a, 810b, 810c, 810d).
  5. Packaging machine (700) according to any one of Claims 1 to 4,
    wherein the closing unit (830, 830a, 830b) is adapted to close the packaging film (650) along a closing line, and wherein the folding unit (820, 820a, 820b) is adapted to fold the film along a folding line;
    wherein the packaging film (650), the sealing line and the folding line together form a funnel, wherein the funnel faces the filling point (630).
  6. Packaging machine (700) according to any one of Claims 1 to 5,
    wherein the packaging machine (700) furthermore comprises a dosing tray (100), wherein the dosing tray (100) and the filling point (630) are movable relative to one another.
  7. Packaging machine (700) according to Claim 6,
    wherein the dosing tray (100) and the filling point (630) are movable towards one another in a substantially horizontally oriented plane.
  8. Packaging machine (700) according to any one of Claims 6 and 7,
    wherein the filling point (630) is designed stationary and the dosing tray (100) is movable relative to the filling point (630), preferably in an essentially horizontally oriented plane.
  9. Packaging machine (700) according to any one of Claims 6 to 8,
    wherein the dosing tray (100) furthermore comprises an identifier (110), preferably an RFID transponder and/or a bar code, wherein the identifier (110) is adapted to store patient-specific information.
  10. Packaging machine (700) according to any one of Claims 1 to 9,
    wherein the packaging machine (700) furthermore comprises a printing unit for printing the packaging film (650) with patient-specific information.
  11. Packaging process (1100) for packaging medicines (441, 442) in solid dosage form into patient-specific blister packs, wherein the packaging method (1100) comprises the following step:
    guiding (1110) a packaging film (650) along underneath a filling point (630), wherein the packaging film (650) is provided for forming blister packs (810a, 810b, 810c, 810d);
    folding (1120) the packaging film (650) towards the filling point (630); and
    closing (1130) the packaging film (650) in the form of a blister pack (810a, 810b, 810c, 810d);
    characterised in that the step of the folding is carried out by means of a first beak (820a) and a second beak (820b),
    wherein the first and second beak (820a, 820b) are each arranged at an angle to the running direction of the packaging film (650) provided by the film transport unit (640), and
    wherein the first and second beak (820a, 820b) are arranged relative to one another in such a way that they are set up to guide the packaging film (650).
  12. Computer programme product which is adapted to prompt a packaging machine (700) according to any one of the Claims 1 to 10 to carry out the packaging process (1100) according to Claim 11.
EP14154292.8A 2014-02-07 2014-02-07 Medicine packaging machine for blister packs for individual patients Not-in-force EP2905230B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14154292.8A EP2905230B1 (en) 2014-02-07 2014-02-07 Medicine packaging machine for blister packs for individual patients

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14154292.8A EP2905230B1 (en) 2014-02-07 2014-02-07 Medicine packaging machine for blister packs for individual patients

Publications (2)

Publication Number Publication Date
EP2905230A1 EP2905230A1 (en) 2015-08-12
EP2905230B1 true EP2905230B1 (en) 2017-05-10

Family

ID=50071458

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14154292.8A Not-in-force EP2905230B1 (en) 2014-02-07 2014-02-07 Medicine packaging machine for blister packs for individual patients

Country Status (1)

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EP (1) EP2905230B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2933837B2 (en) * 1994-10-21 1999-08-16 株式会社湯山製作所 Drug packaging device
KR200214791Y1 (en) * 1998-07-29 2001-06-01 김준호 Tablet dropping device for automatic tablet dispenser
US8600548B2 (en) * 2004-04-24 2013-12-03 Inrange Systems, Inc. Remote medication management system
JP5389007B2 (en) 2010-12-24 2014-01-15 株式会社トーショー Tablet packaging machine

Also Published As

Publication number Publication date
EP2905230A1 (en) 2015-08-12

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