EP2882496A4 - Treatment and diagnosis of melanoma - Google Patents

Treatment and diagnosis of melanoma

Info

Publication number
EP2882496A4
EP2882496A4 EP13829165.3A EP13829165A EP2882496A4 EP 2882496 A4 EP2882496 A4 EP 2882496A4 EP 13829165 A EP13829165 A EP 13829165A EP 2882496 A4 EP2882496 A4 EP 2882496A4
Authority
EP
European Patent Office
Prior art keywords
melanoma
diagnosis
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13829165.3A
Other languages
German (de)
French (fr)
Other versions
EP2882496B1 (en
EP2882496A2 (en
Inventor
Sohail Tavazoie
Nora G Pencheva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Priority to EP19189895.6A priority Critical patent/EP3626309B1/en
Priority to EP23155232.4A priority patent/EP4218935A1/en
Publication of EP2882496A2 publication Critical patent/EP2882496A2/en
Publication of EP2882496A4 publication Critical patent/EP2882496A4/en
Application granted granted Critical
Publication of EP2882496B1 publication Critical patent/EP2882496B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
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EP13829165.3A 2012-08-13 2013-08-13 Treatment and diagnosis of melanoma Active EP2882496B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP19189895.6A EP3626309B1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer
EP23155232.4A EP4218935A1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261682339P 2012-08-13 2012-08-13
US201361784057P 2013-03-14 2013-03-14
PCT/US2013/054690 WO2014028461A2 (en) 2012-08-13 2013-08-13 Treatment and diagnosis of melanoma

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP23155232.4A Division EP4218935A1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer
EP19189895.6A Division EP3626309B1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer
EP19189895.6A Division-Into EP3626309B1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer

Publications (3)

Publication Number Publication Date
EP2882496A2 EP2882496A2 (en) 2015-06-17
EP2882496A4 true EP2882496A4 (en) 2016-07-06
EP2882496B1 EP2882496B1 (en) 2019-10-09

Family

ID=50101591

Family Applications (3)

Application Number Title Priority Date Filing Date
EP23155232.4A Pending EP4218935A1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer
EP13829165.3A Active EP2882496B1 (en) 2012-08-13 2013-08-13 Treatment and diagnosis of melanoma
EP19189895.6A Active EP3626309B1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP23155232.4A Pending EP4218935A1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19189895.6A Active EP3626309B1 (en) 2012-08-13 2013-08-13 Lxrbeta agonist for the treatment of cancer

Country Status (11)

Country Link
US (8) US9526710B2 (en)
EP (3) EP4218935A1 (en)
JP (5) JP6320382B2 (en)
CN (3) CN110037999B (en)
AU (4) AU2013302861A1 (en)
CA (2) CA3211094A1 (en)
DK (1) DK2882496T3 (en)
ES (2) ES2941477T3 (en)
HK (1) HK1212273A1 (en)
HU (1) HUE046292T2 (en)
WO (1) WO2014028461A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2626437A3 (en) 2008-05-14 2013-12-11 Dermtech International Diagnosis of melanoma and solar lentigo by nucleic acid analysis
RS57863B9 (en) 2012-03-02 2019-10-31 Ralexar Therapeutics Inc Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
EP4218935A1 (en) * 2012-08-13 2023-08-02 The Rockefeller University Lxrbeta agonist for the treatment of cancer
WO2015035027A1 (en) 2013-09-04 2015-03-12 Alexar Therapeutics, Inc. Liver x receptor (lxr) modulators
HUE051094T2 (en) 2013-09-04 2021-03-01 Ellora Therapeutics Inc Liver x receptor (lxr) modulators
EP3091970B1 (en) * 2014-01-10 2020-10-28 Rgenix, Inc. Lxr agonists and uses thereof
WO2016100619A2 (en) * 2014-12-17 2016-06-23 Rgenix, Inc. Treatment and diagnosis of cancer
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
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