EP2861238A4 - Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy - Google Patents

Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy

Info

Publication number
EP2861238A4
EP2861238A4 EP13799841.5A EP13799841A EP2861238A4 EP 2861238 A4 EP2861238 A4 EP 2861238A4 EP 13799841 A EP13799841 A EP 13799841A EP 2861238 A4 EP2861238 A4 EP 2861238A4
Authority
EP
European Patent Office
Prior art keywords
cardiac
generation
stem cells
therapy
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13799841.5A
Other languages
German (de)
French (fr)
Other versions
EP2861238A1 (en
Inventor
Michelle Kreke
Rachel Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Capricor Inc
Original Assignee
Capricor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Capricor Inc filed Critical Capricor Inc
Publication of EP2861238A1 publication Critical patent/EP2861238A1/en
Publication of EP2861238A4 publication Critical patent/EP2861238A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP13799841.5A 2012-06-05 2013-05-31 Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy Withdrawn EP2861238A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261655928P 2012-06-05 2012-06-05
PCT/US2013/043772 WO2013184527A1 (en) 2012-06-05 2013-05-31 Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy

Publications (2)

Publication Number Publication Date
EP2861238A1 EP2861238A1 (en) 2015-04-22
EP2861238A4 true EP2861238A4 (en) 2016-03-16

Family

ID=49712519

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13799841.5A Withdrawn EP2861238A4 (en) 2012-06-05 2013-05-31 Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy

Country Status (4)

Country Link
US (2) US9884076B2 (en)
EP (1) EP2861238A4 (en)
JP (1) JP2015521054A (en)
WO (1) WO2013184527A1 (en)

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US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US9884076B2 (en) * 2012-06-05 2018-02-06 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP2882445B1 (en) 2012-08-13 2019-04-24 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
GB201304831D0 (en) * 2013-03-15 2013-05-01 Coretherapix Slu Adult cardiac stem cell population
US20150328263A1 (en) 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US20170360842A1 (en) 2014-12-03 2017-12-21 Capricor, Inc. Processes for producing stable exosome formulations
WO2016183143A1 (en) 2015-05-11 2016-11-17 The Trustees Of Columbia University Inthe City Of New York Engineered adult-like human heart tissue
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2018013851A1 (en) 2016-07-13 2018-01-18 The Trustees Of Columbia University Bioreactor system for engineering tissues
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CARDIOSPHERIC CELLS AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE THE AGING PROCESS AND AGE-RELATED DISEASES
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
IT201700062176A1 (en) * 2017-06-07 2018-12-07 Univ Degli Studi Milano METHOD FOR THE INSULATION OF UNDERPUBLICATION OF CARDIAC CELL PROJECTS AND RELATED USES IN MEDICAL FIELD
US11649424B2 (en) 2017-07-28 2023-05-16 The Trustees Of Columbia University In The City Of New York Smart micro bioreactor platform for high throughput mechanical stimulation of cardiac microtissue
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND YRNA
MX2021013645A (en) 2019-05-13 2022-01-06 Dow Global Technologies Llc Low density, low compression set, long recovery time polyurethane foam.
US12491514B2 (en) 2019-09-26 2025-12-09 University Of Washington Device, system, and method for trapping tissue samples
JP7228711B2 (en) 2019-10-15 2023-02-24 株式会社エビデント CELL ISOLATION SUPPORT METHOD, SYSTEM, AND COMPUTER-READABLE MEDIUM
US20220387518A1 (en) * 2019-11-15 2022-12-08 NeoProgen, Inc Immortalized cardiac stem cells for cardiac repair
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

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Publication number Priority date Publication date Assignee Title
WO2008058216A2 (en) * 2006-11-07 2008-05-15 Keck Graduate Institute Enriched stem cell and progenitor cell populations, and methods of producing and using such populations
WO2010033285A2 (en) * 2008-06-26 2010-03-25 Spectrum Health Method for treating and preventing radiation damage using genetically modified mesenchymal stem cells
WO2010118059A1 (en) * 2009-04-06 2010-10-14 Capricor, Inc. Systems and methods for cardiac tissue repair

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