EP2822651A1

EP2822651A1 - Method and irradiation installation for irradiating a target volume

Info

Publication number: EP2822651A1
Application number: EP13709358.9A
Authority: EP
Inventors: Christoph Bert; Alexander Gemmel; Robert LÜCHTENBORG
Original assignee: GSI Helmholtzzentrum fuer Schwerionenforschung GmbH
Current assignee: GSI Helmholtzzentrum fuer Schwerionenforschung GmbH
Priority date: 2012-03-05
Filing date: 2013-03-05
Publication date: 2015-01-14
Also published as: CN104540547A; WO2013131890A1; JP2018079341A; EP3342463A1; JP2015510781A; DE102012004170B4; EP3342463B1; US9486649B2; JP6392125B2; US20150217139A1; CN104540547B; DE102012004170A1

Abstract

The invention relates to a method and an irradiation installation for irradiating a moving target volume with an ion beam, particularly for the purpose of tumour therapy. Ion radiography measurements are carried out for said target volume, and the irradiation for the deposition and for the radiography are carried out using the same ion beam but in a temporally consecutive manner, with the power of the ion beam being switched between a higher radiography power and a lower deposition power using, for example, a passive power modulator proximal to the patient.

Description

Method and irradiation system for irradiating a target volume

description

Field of the invention

The invention relates to a method and a

Irradiation system for irradiating a target volume with an ion beam, in particular for tumor therapy.

Background of the invention

Movement of the tumor in ion beam therapy poses special challenges to radiation

ensure that the target clinical volume is covered by the prescribed dose despite the movement. For ion beam therapy with a scattered beam, these are typically specially designed

Security margins used what was previously considered sufficient.

With a scanned beam, however, it comes to

Interference effects requiring further action. Among these are beam application by means of so-called gating or so-called beam tracking, each based on a motion detection system, which

Provide tumor movement or a surrogate of tumor movement that is used in real time to potentially interrupt the gating or actively track it (Beam

Tracking). The quality of this signal plays an essential role, since the precision has a direct influence on the signal

Precision of the entire irradiation has. Gating and beam tracking are basically known to the person skilled in the art; see. for gating eg "Respiratory Gated Irradiation System for Heavy-Ion Radiotherapy "by Shinichi Minohara et al., Int. J. Oncology Biol. Phys., Vol. 47, No. 4, pp. 1097-1103, 2000 or" Gated Irradiation with Scanned Particle Beams by Christoph Bert et al Int., J. Oncology Biol. Phys., Vol. 73, No. 4, pp. 1270-1275, 2009, and Beam

Tracking e.g. DE 10 2004 028 035 A1, which are hereby incorporated by reference in each case.

There are various motion detection systems on the market. Some motion detection systems measure

so-called movement surrogate, for example the

Respiratory temperature, movement of the abdominal wall (in 1D, 2D or 3D), the circumference of the abdomen / thorax or the flow of breathing air. In contrast, other motion detection systems directly detect the movement of the tumor and are e.g. on fluoroscopy (with / without implanted radiopaque markers), radio transponders or ultrasound. In addition, combinations of these systems are also used to combine their advantages, such as sparse fluoroscopy (high quality, but dose loading for the

Patients) with a neural network

Belly detection system (lower grade, but no dose burden for the patient). Motion detection systems for direct detection of the

Tumor movement is often associated with surgical intervention in the patient or with a significantly increased dose loading of the patient, e.g. in conventional X-ray fluoroscopy, especially when using high image acquisition rates. External surrogate-based

Motion detection systems are inherently limited to performing a very indirect measurement, why, among other things, the precision of detecting the tumor movement is in need of improvement. Furthermore, the tumor movement, for example in a lung tumor be highly complex and each translational, rotational and

Compressive / dilatatory in all dimensions

Components included.

All these systems also consider the purely geometric movement of the target volume, which in the

Ion therapy only in conjunction e.g. is used with 4DCT records because the range of the beam is from

is essential. For the precise deposition of the desired dose during the irradiation is not only the spatial movement decisive, but rather the effect of the spatial movement on the

Energy loss of the ion beam caused by other factors, e.g. may depend on the local distribution of tissue density. Therefore, these known methods are especially in

In view of the precision further improvement.

From EP 2 400 506 a device is known, which generates at least two different particle beams, of which the second particle beam is used for detecting the movement of the target volume. This will be two

Ion sources used to produce different types of ions, which are brought together in a mixing chamber. However, this procedure can only be used for certain

Use combinations of ions and depends on the type of accelerator device. Furthermore, certain Parameters of the two ion beams only in common

influenced. Therefore, the inventors, in particular in terms of complexity, flexibility and the

Restrictions due to the entanglement of the two

Ion beams in the approach described in EP 2 400 506 here looking for another solution.

General description of the invention

The invention is therefore based on the object to provide a method and an irradiation system for irradiating a target volume with an ion beam, which allow a high precision of the irradiation despite a moving target volume. Another aspect of the object of the invention is a

Method and an irradiation system for irradiating a moving target volume with an ion beam to provide that the adverse effect of the movement of the target volume on the energy loss and the range of the ion beam in the target volume can be determined as precisely as possible.

Yet another aspect of the object of the invention is a

To provide a method and an irradiation system for irradiating a moving target volume with an ion beam, which allows a precise, yet flexible motion detection of the target volume, the

as independent as possible of the accelerator device and possibly even easy to retrofit. The object of the invention is solved by the subject matter of the independent claims. Advantageous developments of the invention are defined in the subclaims. It is a method for irradiating a moving during the irradiation target volume with a

Ion beam provided. The ion beam is first generated by an accelerator device and accelerated and guided to the target volume. The accelerator device comprises in particular a circular accelerator such as a

Cyclotron or synchrotron, a linear accelerator or a combination thereof.

The term ion beam is used in particular

Proton beam or a beam of heavier ions, e.g. Understood oxygen or carbon. Such irradiation systems from the development of the two

Applicants can be found e.g. at the GSI Helmholtz Center for Heavy Ion Research GmbH in Darmstadt or at the

Heidelberg Ion Beam Therapy Center (HIT), where

is irradiated in particular with ¹² C ions. However, other charged hadronic particle beams, such as pions, etc., should not be excluded. According to the invention, the irradiation of the target volume is subdivided in time into at least one radiographic phase and at least one deposition phase in order to reduce the energy of the target volume

Ion beam, i. one and the same ion beam, between the at least one radiographic phase and the at least one deposition phase is to vary in time and in such a way that

i) in the at least one radiography phase the Range of the ion beam distal to the target volume (in the beam direction behind the target volume), so that in the at least one radiographic phase, the ion beam penetrates or transilluminates the target volume to use the ion beam an ionic radiogram of the target volume

by penetrating the target volume

Ion beam is detected with a distal of the target volume arranged Ionenradiographiedetektor and

ii) in the at least one deposition phase, the range of the ion beam is within the target volume, so that the ion beam in the target volume

is stopped to deposit a predetermined, namely planned in the treatment plan dose in the target volume.

By means of ionic radiography, the movement of the

Target volume can be detected, but the radiography and the deposition are carried out with one and the same ion beam, but with different energy and time consecutive. In the radiography phase, the

Therefore, the beam range is adjusted so that the Bragg maximum distal to the patient, more precisely in the

Ionenradiographiedetektor lies to the position of the Bragg maximum by means of energy and spatially resolving

To measure the ionic radiography detector by the ion beam is stopped in the Ionenradiographiedetektor. For this purpose, the energy of the ion beam is in the

Radiography phase to a higher radiographic energy and during the deposition phase to a lower

Deposition energy set. The change between the

Radiography phase and the deposition phase therefore consists in switching the energy of the ion beam. For example, a carbon ion beam is generated, which at an energy E 'in the range of 600 MeV / u, the target volume substantially completely penetrates and with this energy E' for radiography and with a

reduced to an energy E in the range of 250 MeV / u for dose reduction according to the treatment plan. Advantageously, therefore, both the dose deposition and the one with the same ion beam

It is sufficient to vary or "switch over" only the energy.The variation or switching of the beam energy can during the irradiation, in particular in real time, for example within a so-called spill at a synchrotron-based accelerator device or in a

Irradiation break between the spills done. The

Varying or switching between the deposition energy and the radiographic energy is not to be confused with the much smaller change in the energy for irradiation of different isoenergy layers, in which the

Beam range is changed only by a few millimeters and which, if necessary, additionally performed. Advantageously, due to the temporal separation certain parameters of the deposition and the

ion radiography are set independently, in particular the lateral coverage of the

Target volume in a scanning process.

Advantageously, with the invention a

High-precision motion tracking possible. From the Ion radiographs allow to directly determine range changes caused by the movement of the target volume without using a faulty conversion from the X-ray attenuation into the change of the particle range. Namely, in the ionic radiogram, the movement of the target volume is "seen" in the same way as in the deposition, since the energy loss of the same

Ion beam is determined. The only difference between the deposition and the radiography is the

Energy of the ion beam, what the differences in the effect of the movement (translational, rotational,

Compression / dilatation) minimized. In other words, in ion radiography the same physical effect of the movement of the target volume is measured, which also occurs during deposition - except for the different ones

Ion energy, whose influence can be calculated very accurately. Furthermore, a lower dose is to be expected compared to conventional fluoroscopy. In an advantageous manner, the method can nevertheless be carried out without major modifications of the accelerator device. Particularly simple is e.g. the

Accelerator device is set to the higher radiographic energy and then by means of a passive

Energiemodulators, in the deposition phase or the

Deposition phases of the higher radiographic energy to the lower deposition energy is reduced by the ion beam is decelerated in the energy modulator.

Hereby, the energy of the ion beam can easily be varied fast enough to alternately irradiate the tumor (deposition) and perform the radiography, and in real time in response to the Controlling the target volume to be able to intervene in the irradiation. For example, for this purpose, a digital, eg a rotating pie-shaped energy modulator is irradiated proximal to the target volume (in the beam direction in front of the target volume) in which a piece of cake is missing in order to reduce the energy and thus the range of the beam between a target

Position in the target volume and a position distal to the

To modulate patients. In the area of the missing

Pie slice remains the energy of the ion beam

unchanged (radiography phase) and in the remaining area, the energy of the ion beam by deceleration in the

Matter of the modulator on the deposition energy

reduced. This particular digital modulator is again not to be confused with the known ones

Wedge systems for actively tracking the beam range to the movement of the target volume during beam tracking, which may be additionally present.

Alternatively, the energy may be varied by binary modulator plates, such as e.g. in "The PSI Gantry 2: A Second Generation Proton Scanning Gantry" by Eros Pedroni et al., Z. Med. Phys. 14 (2004), 25-34, or by a variation of the settings on the Fiat top at Synchrotron -based acceleration, such as in "Update of an Accelerator Control System for the New Treatment."

Facility at HIMAC "by Y. Iwata et al., In Proceedings of EPAC08, Genoa, Italy, pp. 1800-1802, which are hereby incorporated by reference in this regard, but it is also possible to use a so-called cyc-LINAC. as in "High Frequency Linacs for

Hadrontherapy "by Ugo Amaldi et al

Accelerator Science and Technology, Vol. 2 (2009), 111-131 is described, which hereby in this regard

Reference is incorporated. In the Cyc-LINAC can

Range jumps in the order of magnitude as they go to

Switching between the radiographic energy and the

Deposition energy are necessary by switching off and

Turning on individual cavities of the linear accelerator done. The variation of the energy is accordingly

preferably only after the acceleration in the

Accelerator device (passive modulator) or the end of the acceleration (Cyc-LINAC) made, at least preferably not before acceleration.

In particular, the ionic radiography detector is accordingly an energy-resolving detector, which measures the (residual) energy of the ion beam after passing through the target volume. Hereby, the energy loss caused by the penetration of the target volume can be calculated and, in turn, the effect of the movement of the target volume on the deposition can be determined.

In particular, therefore, one and the same ion beam is used for the deposition and the ionic radiography in the sense that the ion type and the charge are identical and only the energy is different. Thus, one and the same ion beam is used, whose

Energy is consecutively varied in time, but not simultaneously two different ion beams.

In other words, the ionic radiography and the deposition are temporally successive and in the context of this

Condition independently of each other.

In particular, it is not deposited in the radiographic phase and / or not in the deposition phase

Ion-radiographed.

According to a preferred embodiment of the invention, the irradiation of the target volume in time into a plurality of radiographic phases and a plurality of

Subdivided stages of deposition,

wherein the energy of the ion beam, in particular during the irradiation or in an irradiation pause, is alternately switched back and forth between the radiographic phases and the deposition phases such that cyclically alternately:

i) in the radiographic phases, the range of the ion beam is distal to the target volume, so that in the radiographic phases, the ion beam penetrates or transilluminates the target volume and by means of the ion beam ion radiographs of the target volume are recorded by the ion beam with a distal of the target volume

and ii) in the deposition phases, the range of the ion beam in the target volume is such that the ion beam in the target volume is stopped to deposit a predetermined dose in the target volume, respectively. Advantageously, the time sequence of the

Radiography phases are adapted to the movement phases of the target volume. Alternatively or additionally, the time sequence of the radiographic phases to the

Extraction phases of the accelerator device (e.g., spills on a synchrotron) and / or the flow of the

Irradiation of isoenergy layers to be adjusted when the target volume is divided into isoenergy layers which are successively irradiated.

If different in the deposition phases

Isoenergieschichten the target volume can be approached with the ion beam to deposit a predetermined dose in each of the isoenergy layers, e.g. at least before radiation for dose deposition everyone

Isoenergieschicht a radiography measurement according to i) is performed, and / or it is at the beginning of each

Movement phase or each spill performed an ion radiography measurement.

Preferably, the intensity of the ion beam in the at least one or the plurality of deposition phases is set considerably higher than in the at least one or the plurality of radiographic phases, which can also be controlled in real time. This can be in

Advantageously, the dose burden of the patient are kept low.

If the target volume is a target volume cycling during the irradiation, e.g. a lung tumor during respiration, is the cyclic movement of the

Target volume divided into several phases of movement. In connection with the invention it is advantageous to choose the duration of the at least one radiography phase or the plurality of radiographic phases no longer than the duration of the movement phases. Then, if desired, in - preferably at the beginning - everyone

Movement phase carried out an ion-radiography measurement. In other words, the above defined steps i) and ii) performed in the same movement phase or the radiographic phase and

Deposition phase are at least partially in the same phase of movement.

Advantageously, a particularly precise and reliable motion tracking can be achieved hereby.

Particularly preferred is the invention with a

Irradiation with active tracking of the ion beam to compensate for the movement of the target volume (so-called beam tracking) combined. Preferably, the active tracking of the ion beam, i. the beam tracking is controlled in response to the ion radiographic measurement performed by the ionic radiography detector. This control of the active tracking of the ion beam (beam tracking) in response to the radiographic measurement can also be performed in real time. Advantageously, due to the temporal

Separation of radiography and deposition of the

Ion beam in the radiographic phase and in the

Deposition phase are controlled independently. In particular, the ion beam in the radiographic phase, independently of the deposition, can be controlled via the lateral extent of the target volume.

According to a preferred embodiment of the invention, the Ionenradiographiedetektor is designed as a spatially resolving detector, so that in the at least one or

A plurality of radiographic phases a laterally two-dimensionally spatially resolved ionic radiogram, preferably at least of Internal target volume (ITV, according to ICRU 62) is captured by passing through a plurality of halftone dots of the target volume and the range of the ion beam after passing through the target volume for each of the halftone dots in the target volume

Ion radiograph is determined to be at least one

create two-dimensional map of the (water equivalent) range of the ion beam. This map of the range of the ion beam may e.g. as monitoring or

Control information for at least one subsequent

Deposition phase can be used.

An at least two-dimensional representation of the

Target volume in the ionic radiogram advantageously allows a particularly precise and reliable tracking of the movement of the target volume.

If the irradiation procedure uses a scanning method, e.g. is a raster scanning method, the ion beam is referred to as a so-called pencil beam (pencil beam) in the at least one deposition phase or the plurality of

Deposition phases at least scanned over part of the clinical target volume and in the at least one

Radiographic phase or the plurality of radiographic phases at least over a part of the lateral surface of the

The target volume.

In an advantageous manner, a lateral two-dimensional ionic radiogram can hereby be recorded despite the use of a fine pencil beam. Furthermore, it is advantageous that the wobble for radiography measurement can be performed independently of the scanning during the deposition. This is particularly advantageous since

Range losses - if desired - can be precalculated finer than on grid point basis of the deposition. This has e.g. for the sweep, where the beam is driven quickly over a larger range, the advantage that more or even all positions can be compared directly, without to nominal grid positions

to be limited. A finer resolution can e.g. on the order of the CT voxel size. The CT voxel size is e.g. only about 1 mm, while the spacing of the halftone dots in the scanning process is typically in the range of 2 to 3 mm. In the scanning method, in the at least one or the plurality of deposition phases, the ion beam is scanned over the clinical target volume (so-called Clinical Target Volume, CTV according to ICRU 50). Is preferred in the

at least one or the plurality of radiographic phases, the ion beam at least over a part of the lateral area of the internal target volume (ITV, according to ICRU 62) that goes beyond the clinical target volume.

By such a quick wobble becomes the lateral

Position of the beam over all areas of the internal

Target Volume (ITV) - and thus the integral

Extension of the clinical target volume in all

Movement phases - driven. This sweep of the entire internal target volume can be done in a time interval between 1 ms and 1000 ms, for example in the range of 10 ms,

50 ms, 100 ms or 500 ms, so in this time a lateral two-dimensional radiogram of the internal

Target volume can be included.

In other words, when radiography is being measured, a larger area is irradiated than the clinical one

Target volume (CTV), especially if at least the internal target volume (ITV) is covered, that is the clinical

Target volume (CTV) maps in all states of motion, the entire amplitude of movement of the target volume can be covered in an advantageous manner.

Furthermore, a range simulation calculation

be performed to simulated setpoints for the

Range of the ion beam to calculate. During the

Irradiation in the radiographic phase then becomes the

actual (water equivalent) range of the ion beam after penetrating the target volume determined and the determined actual ranges are compared with the simulated setpoints.

It is particularly advantageous to carry out the range simulation calculation for a plurality of grid points and to simulate a multidimensional one

Range map (so-called "Range Map") of the range of the ion beam to create during the irradiation in the

Radiographic phase then becomes the actual range of the ion beam after penetrating the target volume

also determined for a variety of halftone dots and from this a multidimensional ionic radii created with the respective actual ranges of the ion beam and the ionic radii is compared with the simulated setpoint map. By the precalculation of a simulated range map, a so-called range map, in particular a so-called digitally reconstructed range map (DRRM) and by the corresponding comparison between measurement and

Simulating calculation can be made in an advantageous manner, a balance between the movement of the target volume and the movement of the ion beam, in which potentially not only parameters with respect to the movement and range change can be acquired, but also on the interference between the two, in particular the Interplay or Template.

According to a further preferred embodiment of the

Invention is provided with a corresponding internal or external motion measuring system (sometimes referred to as

Motion sensor) measures the movement of the target volume or a movement surrogate. According to the invention, the measurement results with the means of

Ionic radiography detector automatically recorded, e.g. linked by an appropriately programmed microcomputer and the irradiation is in

Controlled response to the linked data. But it can also in a simple way the change between the radiographic phases and the deposition phases in

Response to the measurement results of the motion measuring system are controlled. For example, is considered a combination with the external

Movement surrogate using surrogate information to determine a movement phase in the radiograph whether the target clinical volume (CTV) or individual target site (CTV) test sites are at the planned location. Furthermore, the target volume in the at least one or the plurality of radiographic phases can be irradiated from more than one direction and at least one spatially more than two-dimensional ionic radiogram ("second SD detection") is recorded This is advantageous for irradiation sites which more than Here, it is possible to record radiograms from more than one direction, thus enabling 2.5D detection, and a gantry also has a "RapicArc" analogue

Radiation conceivable, so that in this case within the irradiation period here also radiograms

Different directions can be recorded and thus by appropriate reconstruction algorithms

3D motion plus range can be constructed. Thus, the recording of a 4DIonenCTs is possible.

Overall, this provides very comprehensive information about the movement of the target volume.

In summary, the collected data should be evaluated in terms of expectation in real time, using the methods known from fluoroscopy, i. E. among other things, a comparison between measurement and digital

Reconstructed Range Map (DRRM) (also in 4D, i.e. one DRRM per move phase of 4DCT) or become

Correlation models between radiography and others

Surrogates or recorded in parallel

Fluoroscopy / radiography data used. According to a simple aspect of the invention is disclosed in

Response to the recorded ionic radiogram at

Exceeding predetermined limits, e.g. when comparing between range simulation and energy loss measurement, generates an interlock signal, by means of which the

Irradiation is interrupted.

In principle, therefore, the invention is not limited to pure motion monitoring, but also a verification of the DRRMs obtained is possible, so that e.g. in the event of excessive deviations, the irradiation may be interrupted and possibly even rescheduled. Here is the

Invention particularly advantageous because of

Ionradiographiedetektor which measures ion energy and thus directly with the particle range a dose-relevant factor is detected directly (in contrast to the methods that capture only substitute quantities). Depending on the contrast in the irradiated anatomical region, markers (gold balls, carbon spheres, etc.) can also be implanted to define visible points in the ionic radiogram. The invention is also in inter-fractionally moving or static head-neck

Irradiations applicable to e.g. the storage too

enable or provide an interlock signal in the event of unexpected movement.

According to the invention, an irradiation system is also provided for irradiating a moving target volume with an ion beam, with which the method described above can be carried out. For this includes the irradiation facility:

an accelerator and beam guiding device for generating and accelerating an ion beam and for guiding and directing the ion beam onto the

Target volume,

a control device for controlling the irradiation system,

a device for temporally varying the energy of the ion beam during the irradiation or in a radiation break between at least one

Radiographic phase and at least one deposition phase, in particular in addition to the range change for the dose deposition in different Isoenergiesayer, by means of which means

i) in the at least one radiographic phase, the energy of the ion beam to a higher

Radiography energy is set at which the

Range distal to the target volume or distal to the

Patient (downstream of the beam), more precisely in the ionic radiography detector, so that the ion beam penetrates or transilluminates the target volume,

ii) in the at least one deposition phase, the energy of the ion beam to a lower

Deposition energy is set at which the

Range is within the target volume and the

Stopped ion beam in the target volume to deposit the planned dose in the target volume, and

a distal of the target volume arranged

Ionradiography detector for picking up

Ion radii of the target volume, by the

Target volume penetrating ion beam in the Radiographic phase in the ionic radiography detector

is stopped and detected.

Preferably, the device switches to temporal

Varying the energy of the ion beam, in particular during the irradiation or in a radiation break - and in addition to the range change for starting the isoenergy layers in the deposition phase - in a cyclic sequence of a plurality of radiographic phases and a plurality of deposition phases, the energy of

Ion beam alternately between the radiographic energy and the deposition energy back and forth.

In particular, the ionic radiography detector has a temporal resolution sufficient to be present in each

Radiography phase to generate a new radiogram to possibly control the irradiation in real time.

The control device preferably controls the irradiation system such that in the deposition phases

different Isoenergieschichten the target volume are approached with the ion beam to each deposit a predetermined dose in the Isoenergiesayer and

at least before irradiation for the dose deposition of each isoenergy layer a radiographic measurement with the

Ion radiography detector is performed.

Preferably, a passive energy modulator is used, wherein the ion beam is first generated by the accelerator device with the radiographic energy and in the deposition phase by deceleration in the material of

Energy modulator reduced to the deposition energy becomes. The passive energy modulator is, for example, a round disc with a pie-shaped section and rotates in the ion beam, so that the ion beam cyclically alternately penetrates the material of the disc and is thereby slowed down to the deposition energy

(Deposition phase) or unrestrained by the

pie-shaped cutout happens

(Radiography phase). Further preferably, the control means controls the

Irradiation plant such that the intensity of the ion beam at the deposition in the target volume is higher than in the radiography measurement to keep the additional radiation exposure due to the radiography measurement for the patient low.

Preferably, a microcomputer in the subdivided

Preparation of the irradiation the movement of a cyclically moving target volume, e.g. by breathing, in several phases of movement. If a pie-shaped

Energy modulator is used, its shape and

Rotation speed is preferably adapted to the duration of the movement phases so that the duration of the

Radiographic phases is shorter than the duration of the

Movement phases.

If a means for actively tracking the

Ion beam to compensate for the movement of the target volume (beam tracking) is present, the control device is preferably hereby operatively connected to the beam

Tracking in response to the means of Ionradiographiedetektors recorded ionic radiograms.

The ionic radiography detector is preferably an energy and location-resolving detector which receives an energy and laterally two-dimensionally spatially resolved ionic radiogram of at least parts of the internal target volume (ITV). A computing device then determines the

Range of the ion beam after penetrating the

Target volume for each of the grid points and creates a two-dimensional map of the range of the ion beam after penetrating the target volume.

The preferably included scanning device for scanning the ion pencil beam (diameter typically a few millimeters) is controlled by the controller so that the ion beam for dose deposition two- or

is scanned three-dimensionally over the target volume and for radiography at least over a portion of the lateral surface of the target volume, regardless of the scanning for deposition, because temporal consecutive, is wobbled. For scanning and wobbling the same scanning magnets can be used, but it is conceivable separate magnets for the wobble

to install, e.g. if the scan magnets for the wobble are not fast enough.

The controller controls the scanning device (with or without separate wobbling magnets) e.g. such that the ion beam is scanned at the dose position over the target clinical volume (CTV, ICRU 50) and at

Radiograph over a larger lateral area than that clinical target volume, especially on the internal

Target volume (ITV, ICRU 62).

The range simulation calculation described above is typically performed by a suitably programmed microcomputer, which also performs the comparison with the ranges actually determined and subsequently generates, preferably in real time, control signals to which e.g. the irradiation is adapted or interrupted. The same applies to the embodiment in which the multidimensional actually measured radiograms are compared with the simulated nominal value map. In particular, the control device records the measurement results of the motion measurement system and the ionic radiograms of the ionic radiography detector, automatically combines the measurement results and the ionic radiograms, and controls

then the irradiation in response to this linked data.

Alternatively, the controller controls the change between the radiographic phases and the deposition phases in response to the measurement results of the

Motion measurement system.

Further preferably, the irradiation system has a plurality of jet pipes and / or a rotatable gantry, with which the target volume can be irradiated from more than one direction to a locally more than two-dimensional

To record an ionic radiogram. The method and the irradiation system according to the invention are in particular designed for tumor therapy. But they can also be used to irradiate a target volume that is not human or

animal body belongs. For example, can a phantom,

be irradiated in particular with a target volume for motion simulation.

In the following the invention is based on

Embodiments and explained in more detail with reference to the figures, wherein the same and similar elements are partially provided with the same reference numerals and the features of the various embodiments can be combined.

Brief description of the figures

Show it:

Fig. 1 is a schematic representation of the irradiation

a moving target volume with a

scattered ion beam

Fig. 2 is a schematic representation of the irradiation

a moving target volume with a scanned ion beam

Fig. 3 is a schematic representation of a

Irradiation plant with a scattered

Ion beam according to the prior art

Fig. 4 is a schematic representation of a

Irradiation unit with a scanned ion beam according to the prior art

Fig. 5 is a schematic representation of a

Irradiation unit with a scanned Ion beam and an energy modulator according to an embodiment of the invention

Fig. 6 is a schematic representation of a

Irradiation unit with scanned ion beam and an energy modulator according to another

Embodiment of the invention

Fig. 7 is a schematic representation of a

Irradiation plant with a downstream

Linear accelerator according to another embodiment of the invention

Fig. 8 is a schematic representation of the irradiation of a target volume combined with a

Movement measurement system

9 is a schematic representation of an irradiation of a target volume of two different

directions

10 shows a schematic representation of an irradiation of a target volume with rotating gantry

11 is an illustration of the timing of the

Radiographic phases and deposition phases according to an embodiment of the invention

12 is a diagram of the radiographic phases and

Deposition phases according to another

Embodiment of the invention

Fig. 13 is a representation of the radiographic phases and

Deposition phases according to another

Embodiment of the invention

14 is a flowchart of irradiation according to a

Embodiment of the invention

Fig. 15 is a flowchart of a real time evaluation with

DRRM according to an embodiment of the invention 16 is a flowchart of a combination of

Irradiation with surrogate measurement according to a

Embodiment of the Invention Detailed Description of the Invention

FIG. 1 shows a tumor as a clinical target volume 12 (CTV) according to ICRU 50 in a reference movement phase 12a. The tumor 12 moves within an envelope within which the motion states 12a, 12b, 12c and 12d are mapped by way of example. The envelope forms the internal target volume 14 (ITV) according to ICRU 62.

To use the Radiographiemessung with the

ionic radiography detector 20 information about

As a rule, no further measures are required in the case of passive irradiation with scattered ion beam 16, because anyway the entire internal target volume 14 is irradiated at the same time.

Fig. 2 shows the irradiation of the target clinical volume 12 with a scanned ion beam 18. To the means of

Radiographic measurement with the ionic radiography detector 20 To obtain information about the range distribution in the entire internal target volume 14, the ion beam is hereby swept over the entire internal target volume 14, which is schematically represented by the dotted arrows 18

is symbolized. The wobble is the fine

Pencil beam is moved rapidly over the lateral extent of the entire internal target volume 14, which is shown in FIG. 2 only one dimension is shown because the second lateral dimension is perpendicular to the plane of the drawing.

Optionally, the measured range distribution is e.g. compared with a Digitally Reconstructed Range Map (DRRM). Alternatively, it is also possible to obtain information about the current beam position or different beam positions by comparing the radiographic measurement carried out by means of the ionic radiography detector 20 at the current raster position or at a plurality of raster positions that have been approached representatively with a DRRM.

In other words, in the Digitally Reconstructed Range Maps (DRRM) the expected range loss of the

Radiographic beam which is irradiated from its specific direction at a certain position with a certain energy through a CT (or a phase of a 4D CT) stored for a plurality of beams. During radiography the measured values of the radiography measurement are compared with the DRRM. This is used e.g. the

Motion phase determination of a movement surrogate

Verified or independent determination of the movement phase is made in response to the Radiographiemessung.

3 shows a known irradiation system 1 with an accelerator device 22 comprising a cyclotron 24 and a beam guiding device 26. The ion beam 16 is scattered with a scattering system 28. Then the range is with a

Range modulator 30 (rank modulator) and a

Range slider 32 (ranked shifter) widened. Subsequently, the scattered ion beam 16 is collimated with a collimator 34 to the extent of the internal target volume. The dose field is adjusted by means of a compensator 36 to the distal contour of the target volume. The originally fine ion beam 16, as he from the

Accelerator 22 is emitted is by the scattering system and various subsequent passive

Beam shaping devices adapted to the target volume. It is a completely passive one

Beam modeling system.

Fig. 4 shows a known irradiation apparatus 1 with an intensity-controlled magnetic scanning system, as e.g. is used at the GSI in Darmstadt. The

Accelerator device 22 in this example comprises a synchrotron 24 'and a beam guiding device 26, which guides the ion beam into the irradiation chamber (not shown) in order to supply the target volume 12 there

irradiate. The fine ion beam 18, also referred to as Pencil Beam, is scanned over the lateral extent of the target volume by a scanning device 38, which comprises fast scanning magnets 38a, 38b for scanning the ion beam 18 in the X and Y directions. In order to scan the target volume three-dimensionally, the Bragg peak is scanned over a plurality of isoenergy layers 13a to 13i. The ion beam 18 is, for example, an 80 to 430 MeV / u ¹² C ion beam. The corresponding beam parameters of the ion beam 18 are controlled by the synchrotron control system 40 and pulsed from the synchrotron 24 '. Typically, these isoenergy layers

13a to 13i from distal (highest energy, E _max ) to proximal (lowest energy, E _m i _n ) scanned. The scanning of the Target volume 12 is first prepared in a preparatory phase, the so-called radiation planning, in which an irradiation plan is calculated and determined, which is stored in the therapy control system 42. The therapy control system 42 is alternate

Interacting with the synchrotron control system 40 and controls, among other things, the power supply 44 of

Scanning device 38, to control the respective grid point for dose deposition. Furthermore, the beam position is monitored with a beam position monitor 46 and transmitted to the therapy control system 42.

With reference to FIG. 5, an irradiation system with scanning system 38 according to FIG. 4 is shown, wherein, according to the invention, a pie-shaped energy modulator 48 proximal to the target volume or proximal of the target volume, respectively

Beam position monitor 46 is arranged. In this

Example is the energy modulator 48 distal to the

Scanning device 38 is arranged. The actual irradiation of the target volume 12, i. the dose deposition is with a therapy energy or deposition energy E

carried out. The accelerator device 22, however, supplies the considerably higher radiographic energy E '= E + dE, where dE corresponds to the energy loss during the passage through the pie-shaped energy modulator 48. Of the

Energy modulator 48 rotates to define the timing of deposition phases and radiographic phases. In the times when the energy modulator is irradiated, namely in the massive region 48a in which the modulation material is located, the energy modulator 48 modulates the ion beam energy of the

Radiographic energy E 'on the deposition energy E so that the target volume can be irradiated as usual, which is indicated by the solid line 50

is represented. In the time interval in which the

Ion beam passes through the recess 48b of the energy modulator, occurs no energy loss dE, so that on

Patients the radiographic energy E '= E + dE arrives. The radiographic energy E 'or the energy loss dE is selected to be sufficiently large so that the target volume and, in the case of therapeutic irradiation, the entire patient is completely penetrated by the ion beam, which is represented by the dashed line 52. In this case, with the location and energy resolving ion radiography detector 20, which distal to the

Target volume 12 is arranged and has a size which should cover at least the entire internal target volume, spatially resolved, the energy loss in the target volume 12 and measured in the patient. Consequently, in this radiographic phase with the radiographic energy E 'becomes a

Ion radiography measurement performed with the ionic radiography detector 20. For example, the

Radiographic energy about E '= 600 MeV / u, the

Deposition energy about E = 250 MeV / u and the

Energy loss in the energy modulator about dE = 350 MeV / u. The location and energy resolving ionic radiography detector 20 in this example comprises a stack of up to 61 parallel ionization chambers between each

Absorber plates made of PMMA are used. The thickness of the absorber plates is chosen between 0.5 mm and 5 mm depending on the requirements. The ionic radiography detector 20 may further comprise a fixed or variable pre-absorber which increases the water equivalent reach by 90 mm reduces to 90 mm. The active area of the

Ion radiography detector 20 is, for example

300 x 300 mm ² in order to provide at least one measuring field of 200 x 200 mm ² for the ion beam 18.

The energy modulator 48 is in operative connection with the control device 39 of the irradiation system 1

Control device 39, the rotation of the

Control energy modulator 48 and / or the energy modulator 48 provides feedback on its respective

Angular position to the control device 39, including the control of the accelerator device 22, the scanning device 38 and the means of the rotating

Energiemodulators 48 defined radiographic phases and deposition phases time to synchronize or synchronize.

The irradiation system 1 additionally comprises a known motion measuring system 54, which has a

Information about the movement of the target volume 12 to the controller 39 is transmitted. This can be a direct motion information with an internal motion measurement system or a surrogate information with an external motion

Be a movement measuring system.

With respect to the use of the additional internal or external motion sensing system 54, e.g. the following systems. As internal movement measuring system:

• kV / MV imaging (photons) fluoroscopy

o with implanted markers

o without implanted markers

• implanted electromagnetic transponders • Ultrasound

and as an external motion measurement system for measuring a movement surrogate:

• Measurement of the patient's breath:

o Volume measurement

o temperature measurement

o Measurement of air flow velocity

• Measurement of patient surface

o Film coated markers (e.g., infrared emitter) o Stereo camera for filming the body surface

Various motion measuring systems can also be combined.

Referring to Fig. 6, an alternative

Embodiment of the invention shown, in which the energy modulator proximal to the scanning device 38th

is arranged. In this example, the energy modulator is designed as a binary energy modulator plate 48 ', which defines the reduction of the beam energy from the radiographic energy to the deposition energy by moving the energy modulator plate 48' in and out of the beam path of the ion beam 18. By moving out of the energy modulator plate 48 ', the beam energy is increased from the deposition energy E to the radiographic energy E' = E + dE, so that the target volume 12 or at the

Tumor therapy the entire patient from the ion beam

is penetrated in order to perform the Radiographiemessung can. By driving in the energy modulator plate 48 ', the radiographic energy E' delivered by the accelerator device is reduced by dE to the deposition energy E to irradiate the target volume 12 so as to deposit the dose set in the irradiation plan which is represented by the solid line 50 in FIG. 6, the fourth isoenergy layer 13d seen from the distal side being irradiated here by way of example. Since, in this example, the energy modulator 48 'is located proximal to the scanner 38, the

Scanning device 38 and possibly even more distal of

Energy modulator 48 'arranged magnets of the beam guide to be readjusted. This can be done in real time with correspondingly fast magnet systems, controlled by the

Control device 39 can be realized. The positioning of the energy modulator in front of the scanner 38 has the advantage of a lower patient burden

Fragments generated in the energy modulator. The positioning of the energy modulator distal to the

Scanning device or before the patient, as shown in Fig. 5, has the advantage that to a corresponding readjustment of the scanning device 38 and others

Beam guide elements can be dispensed with.

FIG. 7 shows another embodiment in which the energy variation between the radiographic energy and the deposition energy is performed by the accelerator device 22. For this purpose, e.g. a cyclotron 24 with a downstream linear accelerator 58. Incidentally, the structure is substantially the same as that in FIGS. 5 and 6. In contrast to the passive energy modulators 48, 48 'used in FIGS. 5 and 6, the

Energy variation between the deposition energy and the radiographic energy in this example with the

downstream linear accelerator 58 can be accomplished. For the deposition phase, one or more the accelerator cavities 58a to 58g turned off to reduce the energy of the ion beam from the radiographic energy to the deposition energy. For this example, the Cyc-LINAC can be used, which is described in the review article cited above by Ugo Amaldi et al.

FIG. 8 shows the combination of the movement measuring system 54 with the radiographic measurement by means of the

Radiography detector 20 according to the present invention.

The known motion measuring system 54 transmits the data on the movement of the target volume to the

Control device 39. In the radiographic phase, the ionic radiography detector 20 records ionic ionograms of the target volume (and of the surrounding tissue) by means of the ion beam 18 which radiates the target volume 12 or the patient 15. The controller 39 compares the ionic radiography measurements 60 with the measurements of the

Motion measuring system 54, which e.g. may be a surrogate in the form of a stereo camera image of the patient's breast. With the movement measuring system 54 can first in itself

known manner, the movement phase of the patient to be determined. When the controller 39 determines that the determined by means of the Bewegungsmesssystems 54

Movement phase - which enters the beam application 62, e.g. gating or beam tracking is used - with the expected in this phase of motion ionic radiation results, the irradiation is continued. On the other hand, if the ion radiography result has predetermined thresholds of agreement with the expected one

ionic radiography results, the Control device 39, the beam application 62 from or adapted.

9 shows an embodiment of the invention, in which the target volume 12 or the patient 15 from two different directions with the ion beam 18th

is irradiated. For receiving the ionic radiograms, two ionradiographic detectors 20 are accordingly

intended. If, as in the present example, the ion beam 18 is irradiated from at least two different directions, ionic radiograms stand out

different directions available. The with the

Ion radiography measurements 60 of at least two

Information obtained in different directions is a purely two-dimensional information of an individual

However, this type of irradiation is referred to as 2.5D radiography. In either case, the beam application 62 can be selectively controlled with the respective ionic radiogram.

10 shows an exemplary embodiment with a rotating gantry, wherein the rotation of the beam application 62 is symbolized by the arrow 64. The Ionenradiographiedetektor 20 is opposite to the beam application also with the gantry (not shown) co-rotated, which is symbolized by the arrow 66. Thus, similar to the so-called RapidArc method (photons), the

Beam exit and the Ionenradiographiedetektor 20 are rotated during the radiographic irradiation to the patient, so that 3D-Ionenradiogramme can be created similar to an X-ray CT, but here in addition to that inherent to the ionic radiogram

Range information.

11 shows an exemplary embodiment of a time sequence of the radiographic phases and deposition phases. The uppermost graph 72 shows the energy of the ion beam radiating between radiographic phases 74

Radiography energy and deposition phases 76 with

lower deposition energy cyclically back and forth

is switched. Opposite to the energy 72 of the

Ion beam, the intensity 78 of the ion beam is controlled, i. that in the radiographic phases 74 a lower intensity of the ion beam is applied than in the deposition phases 76. Therefore, the

Radiation exposure in the inventive method advantageously relatively low. The factor by which the ion beam intensity in the radiographic phase can be reduced compared to the deposition phase depends e.g. from the speed of the wobble magnets and the

Characteristic of the radiography detector 20 from. ever

slower the wobble magnets and the

Ionradiography detector 20 operate, the greater the intensity reduction can be usually selected.

Basically, a reduction of the intensity in the radiography phase compared to the deposition phase by a factor of 10 to 100 appears possible.

In the example shown in Fig. 11, the cycle of the change between the radiographic phases and the

Deposition phases tuned to the scanning of the target volume 12 with the scanning device 38 for deposition. For example, the change takes place from the deposition phase 76 in FIG the radiographic phase 74 after a predetermined number of irradiated halftone dots, eg after 100 halftone dots. Thus, the duration of the deposition phase 76 corresponds to the period of irradiation of 100 halftone dots. The

The duration of the radiographic phases 74 is chosen to be significantly shorter than the duration of the deposition phases 76.

The example shown relates to a

Irradiation plant 1 with a synchrotron 24 '. As is known to those skilled in the art, the ion beam is discontinuously extracted from a synchrotron in so-called spills, the spills being labeled 80 and the spill pauses 82. The movement of the target volume 12 is in eleven

Movement phases 12a to 12k divided, which projects in this example in two spills. The motion cycle 12a to 12k ends in this example at t _B wp at the

dashed line 84 at which a new

As far as the movement of the target volume 12 relates to the respiration of a patient, a movement cycle (breathing cycle) typically takes in the region of 5 seconds.

Fig. 12 indicates an alternative cycle

Radiographic phases 74 and deposition phases 76, wherein the radiographic deposition cycle is adapted to the movement phases 12a to 12k, or with the movement phases

is synchronized. The change from a deposition phase 76 into a radiographic phase 74 takes place at the same time as the change from one movement phase to the next. For this purpose, the cycle of radiographic phases and deposition phases is triggered by the measurement of the motion measuring system 54, to the extent that the change from the deposition phase 76 to the radiographic phase 74 occurs when the

Motion measuring system 54 the change to the next

Motion phase detected. This has the advantage that a separate radiographic measurement is carried out for each movement phase. In this example, therefore

Cycle of radiographic phases and deposition phases synchronized with the cycle of motion phases. Referring to FIGS. 5 to 7, the synchronization is performed by the controller 39.

Referring to FIG. 13, the cycle may be off

Radiography phases and deposition phases also at the

Interval of the ray extraction, using the example of

Synchrotrons 24 'with the spill 80 time

be synchronized. In the present case that means too

At the beginning of each spill 80 there is a radiographic phase and for the remainder of the spill dose is deposited in the target volume 12. Also this synchronization can with a

correspondingly programmed control device 39

be performed.

Fig. 14 shows a flow chart for irradiation in the context of the present invention with radiographic phases and

(optional) real-time intensity control and (optional) wobble with the scanning system 38.

In step 201, radiotherapy is prepared, which includes diagnosis, imaging, and 4D radiation planning, etc.

and is generally known to the person skilled in the art.

In step 202, the radiographic parameters are determined, comprising the radiographic energy E ', the beam intensity 78 in the radiographic phases 74 and / or the field size for the radiographic measurement and / or frequency as well as the time or cycle of the radiographic measurements. In step 203, a DRRM is calculated, eg by

spatially resolved calculation of the energy loss of the

Ion beam in the patient's body 15 based on the CT and irradiation planning data (beam direction, energy, etc.). Step 204a defines a deposition phase 76 with the lower deposition energy E and higher

Beam intensity 78, so in the case of tumor therapy, a phase of therapeutic radiation. As already described above, a deposition phase 76 may comprise the irradiation of a plurality of halftone dots.

In step 204b, the parameters of the irradiation facility 1 are adapted for the subsequent radiographic measurement. This includes in particular the variation of the beam energy 72 from the deposition energy E to the radiographic energy E ', e.g. with the energy modulator 48, 48 'and possibly the

Reduction of beam intensity 78. Both can be done in real time. In step 204c, the radiographic measurement is performed, eg, by sweeping the entire internal target volume 14 (ITV) by wobbling with the ion beam 18. For this purpose, for example, the scanner magnets 38a, 38b are controlled accordingly by the control device 39. Depending on the result of the radiography measurement, the irradiation is interrupted if necessary in step 205. It may even be followed by a new treatment planning. If the radiography measurement within predetermined

Limits is located, in step 204d - if necessary - the irradiation can be adapted. Subsequently, in a further step 204b, the irradiation system is switched back to the deposition energy E, e.g. by

Driving in the energy modulator plate 48 'in the

Beam path or corresponding rotation of the pie-like energy modulator 48 and by corresponding resumption of the scan operation for dose deposition in the target volume, which in turn is then continued in step 204a.

Thus, the radiography measurement is used as a control parameter within the control loop 204a to 204d.

When the entire treatment plan has been completed, the irradiation is also ended in step 205. The

Adaptation of the irradiation parameters when changing from the radiographic phase 74 into the deposition phase 76 and

conversely in steps 204b, the energy modulator 48 ', 48 and the scanning device 38 are actuated accordingly by the control device 39. FIG. 15 shows a flow chart for combining the

Radiography measurement with the measurement results of the

Motion measuring system 54.

In step 301, the radiography measurement is performed with the

Ion radiography detector 20 performed. In step 302, simultaneously and independently thereof, the movement of the target volume by means of the

Motion detection system 54, e.g. in form of a

Surrogate measurement recorded.

In step 303, the controller 39 compares the ion-radiographic measurement with the expectation of FIG

Surrogate measurement and falls in response to the result of this comparison, a decision on the other

Course or a possible termination of the irradiation.

In step 304, the irradiation of the target volume then takes place in a deposition phase 76 when continuing. Otherwise, the method sequence corresponds to that in FIG. 14.

16 shows a flow chart of a real time evaluation with DRRM.

In step 401, for each 4DCT phase, a DRRM

calculated. This step takes place in particular before the irradiation. Box 402 symbolizes the thus calculated DRRMs.

In step 403, a radiography measurement in a

Radiography phase 74 performed. In step 404, for example by means of the control device 39, the result of the radiographic measurement from step 403 is compared with the expectation from the precalculated DRRM 402. Depending on the result of this comparison 404, if necessary, the irradiation is adapted in step 405 or

canceled . It will be apparent to those skilled in the art that the above-described embodiments are to be read by way of example, and that the invention is not limited thereto, but that it can be varied in many ways without departing from the scope of the claims. Furthermore, it will be appreciated that the features are independent of whether they are included in the description, the claims, the figures or

are otherwise disclosed, also individually essential

Define components of the invention, even if they are described together with other features.

Claims

Method for irradiating a target volume (12) with an ion beam (16, 18),

wherein the irradiation of the target volume (12) is subdivided in time into at least one radiographic phase (74) and at least one deposition phase (76), wherein the energy (72) of the ion beam (16, 18) between the at least one radiographic phase (74) and the at least a deposition phase (76) is varied over time such that

i) in the at least one radiographic phase (74) the range of the ion beam (16, 18) is distal to the target volume (12), so that the ion beam (16, 18) penetrates the target volume (12), and wherein by means of the ion beam (16 , 18) an ionic radiogram of the target volume (12) is recorded by the

Ion beam (16, 18) with a distally of the target volume arranged ionic radiography detector (20) is detected and

ii) in the at least one deposition phase (76), the range of the ion beam (16, 18) is within the target volume (12) such that the ion beam (16, 18) in the target volume (12) is stopped by a predetermined dose in to deposit the target volume (12).

Method according to claim 1,

wherein the irradiation of the target volume (12) is subdivided in time into a plurality of radiographic phases (74) and a plurality of deposition phases (76), wherein the energy (72) of the ion beam (16, 18) between the radiographic phases (74) and the

Deposition phases (76) alternately back and forth

is switched such that cyclically alternately:

i) in the radiographic phases (74) the

Range of the ion beam (16, 18) distal to the

Target volume (12) is such that the ion beam (16, 18) penetrates the target volume (12) and by means of the ion beam (16, 18) ionic radiograms of the target volume (12) are recorded by the ion beam (16, 18) with a distal of the target volume (12) arranged Ionenradiographiedetektor (20) is detected and

ii) in the deposition phases (76) the

Range of the ion beam (16, 18) in the target volume (12), so that the ion beam (16, 18) is stopped in the target volume (12), each to a predetermined dose in the target volume (12)

deposit.

Method according to claim 2,

wherein in the deposition phases (76) different

Isoenergieschichten (13a-13i) of the target volume (12) with the ion beam (16, 18) are approached to each deposit a predetermined dose in the Isoenergiesayer and at least before the irradiation for

Dose deposition of each isoenergy layer one

Radiography measurement according to i) is performed.

Method according to one of the preceding claims, wherein the energy (72) of the ion beam (16, 18) by means of a passive energy modulator (48, 48 '), in the at least one deposition phase (76) or the plurality of deposition phases (76) of the higher Energy to radiography is reduced to the lower energy for deposition.

Method according to one of the preceding claims, wherein the intensity (78) of the ion beam (16, 18) in the at least one or the plurality of

Deposition phases (76) is set considerably higher than in the at least one or the plurality of

Radiographic phases (74).

Method according to one of the preceding claims, wherein the target volume (12) accumulates during the

Radiation is cyclically moving target volume and the cyclic movement of the target volume in several

Movement phases (12a-12k) is divided, and wherein the duration of the at least one radiographic phase (74) or the plurality of radiographic phases each is no longer than the duration of the movement phases.

Method according to one of the preceding claims, wherein the movement of the target volume (12) is compensated by means of active tracking of the ion beam and the active tracking of the ion beam in

Responding to the means of

Ion radiography detector (20) recorded

Ion radii is controlled.

Method according to one of the preceding claims, wherein in the at least one or the plurality of radiographic phases (74) a laterally two-dimensionally spatially resolved ionic radiogram is recorded by a plurality of grid points of the target volume (12). and the range of the ion beam after penetrating the target volume for each of the screen dots in the ionic radiogram is determined to produce an at least two-dimensional map of the range of the ion beam.

The method of any one of the preceding claims, wherein the irradiation method is a scanning method and the ion beam (18) is wobbled in at least one or more radiographic phases (74) over at least a portion of the lateral surface of the target volume (12)

Method according to claim 9,

wherein in the at least one or the plurality of deposition phases (76) the ion beam passes over the

target volume (CTV, ICRU 50) is scanned, and wherein the ion beam in at least one or more radiographic phases (74) is at least one above the target clinical volume (CTV).

wobbling out of the lateral area of the internal target volume (14, ITV, ICRU 62).

Method according to one of the preceding claims, wherein a range simulation calculation is performed in order to calculate simulated setpoint values for the range of the ion beam after passing through the target volume (12) in the radiographic phase (74),

being during the irradiation in the

Radiography phase the actual range of the

Ion beam after penetration of the target volume (12) is determined and the ranges actually determined are compared with the simulated setpoints.

The method of any one of the preceding claims, wherein a range simulation calculation for a plurality of halftone dots is performed to produce a multi-dimensional simulated set point map (DRRM) of the range of the ion beam,

being during the irradiation in the

Radiographiephase (74) determines the actual range of the ion beam after passing through the target volume for a plurality of grid points and from this a multidimensional ion radii with the

each actual range of the ion beam is created and

the ionic radiogram is compared with the simulated set point map.

Method according to one of the preceding claims, wherein additionally with an internal or external

Motion measurement system (54) the movement of the target volume (12) or a movement surrogate is measured and the measurement results of the motion measuring system (54) are automatically linked to the ionic radiograph taken by the Ionenradiographiedetektors Ionenradiogrammen and the irradiation is controlled in response to the linked data.

Motion measuring system (54) the movement of the target volume (12) or a movement surrogate is measured and the Change between the radiographic phases (74) and the deposition phases (76) in response to the

Measurement results of the motion measuring system (54) is controlled.

15. The method according to any one of the preceding claims,

wherein the target volume (12) in the at least one or the plurality of radiographic phases (74) is irradiated from more than one direction and at least one spatially more than two-dimensional ionic radiogram is recorded therewith.

Irradiation plant (1) for irradiating a

Target volume (12) with an ion beam (16, 18), in particular with the method according to one of

preceding claims, comprising:

an accelerator and beam guidance device (22, 24, 24 ', 26) for generating and accelerating an ion beam and for guiding and directing the ion beam onto the target volume (12),

a control device (39) for controlling the irradiation,

a device (48, 48 ', 58a-58g) for temporally varying the energy of the ion beam (16, 18) between at least one radiographic phase (74) and at least one deposition phase (76), by means of which i) in the at least one radiographic phase (74 ) the energy (72) of the ion beam (16, 18) is set to a radiographic energy in which the range is distal to the target volume (12) and the ion beam (16, 18) is the target volume (12).

penetrates, ii) in the at least one deposition phase (76) the energy (72) of the ion beam (16, 18) is set to a deposition energy at which the range is within the target volume (12) and the ion beam (16, 18) in the target volume (12) is stopped to deposit a predetermined dose in the target volume (12),

an ion radiography detector (20) disposed distal of the target volume (12) for receiving

Ion radii of the target volume (12), by the the

Target volume (12) penetrating ion beam (16, 18) is detected in the radiographic phase (74).

Irradiation plant according to claim 16,

wherein the means for temporally varying the energy (72) of the ion beam (16, 18) in one

alternating sequence of a plurality of

Radiographic phases (74) and a plurality of

Deposition phases (76) switches the energy of the ion beam (16, 18) back and forth, such that cyclically alternating:

i) in the radiographic phases (74) the

Energy (72) of the ion beam (16, 18) is set in each case to the radiographic energy, so that the

Range distal to the target volume (12) and the ion beam (16, 18) penetrates the target volume (12), ii) in the deposition phases (76)

Energy of the ion beam is adjusted to the deposition energy, so that the range is within the target volume (12) and the ion beam (16, 18) is stopped in the target volume (12), each to a predetermined dose in the target volume (12) deposit.

18. Irradiation plant according to claim 17,

wherein the control device (39) is designed to control the irradiation system (1) such that

in the depositional phases (76) different

Isoenergieschichten (13a-13i) of the target volume (12) are approached with the ion beam (16, 18) to deposit each a predetermined dose in the Isoenergiesayer and

at least before the irradiation for the dose deposition of each isoenergy layer, a radiographic measurement is carried out with the ionic radiography detector (20). 19. Irradiation system according to one of claims 16 to 18, wherein the means for temporally varying the energy (72) of the ion beam (16, 18) comprises a passive energy modulator (48, 48 ') which in the at least one deposition phase (76) or the plurality of deposition phases (76) the energy (72) of the

Ion beam (16, 18) from the higher

Radiography energy to the lower

Minimizes deposition energy. 20. Irradiation system according to one of claims 16 to 19, wherein the control device (39) is adapted to control the irradiation system (1) such that the intensity (78) of the ion beam (16, 18) in the at least one or the plurality of Deposition phases (76) is set considerably higher than in the at least one or the plurality of Radiography Phases (74)

Irradiation system according to one of Claims 16 to 20, comprising means for dividing the movement of a target volume (12) cyclically moving during the irradiation into a plurality of movement phases (12a-12k), the time duration of the at least one

Radiographic phase (74) or the majority of

Radiographic phases (74) are each no longer than the duration of the movement phases.

Irradiation plant according to one of claims 16 to 21, comprising means for actively tracking the ion beam to compensate for the movement of the ion beam

Target volume (12), wherein the control device (39) is formed, the active tracking of the ion beam in response to the means of

Ion radiography detector (20) recorded

To control ionic radiograms.

Irradiation system according to one of claims 16 to 22, wherein the ionic radiography detector (20) a

Spatially resolving detector is, in each case a laterally two-dimensionally spatially resolved ionic radiogram

receives, by in the at least one or the

Plurality of radiographic phases (74) one each

Plurality of halftone dots of the target volume (12) are penetrated by the ion beam,

further comprising a computing device for

Determining the range of the ion beam (16, 18) after penetrating the target volume (12) for each of the halftone dots in the ionic radiograms and creating them an at least two-dimensional map of the range of the ion beam after penetrating the target volume (12).

Irradiation plant according to one of claims 16 to 23, comprising a scanning device (38) for scanning the ion beam (18) over the target volume (12), wherein the control device (39) is formed, the

Scanning device (38) to control that

the ion beam (18) is scanned across the target volume (12) for dose deposition in the at least one or the plurality of deposition phases (76); and

the ion beam (18) is swept in at least one or a plurality of radiographic phases (74) over at least a portion of the lateral surface of the target volume (12).

25. Irradiation plant according to claim 24,

wherein the control device (39) is designed to control the scanning device (38) such that the

Ion beam (18) in the at least one or

A plurality of deposition phases (76) over the target clinical volume (CTV, ICRU 50) is scanned and the

Ion beam (18) in the at least one or

Plurality of radiographic phases (74) over at least one of the target clinical volume (12)

26. Irradiation system according to one of claims 16 to 25, comprising a computing device, formed:

to carry out a range Simulation calculation to simulated setpoints for the range of the ion beam after penetrating the target volume (12) in the at least one or

To calculate a plurality of radiographic phases (74)

to determine the actual range of the

Ion beam in response to readings of the

Ionradiographiedetektors (20) after penetrating the target volume (12) in the at least one or the Mahrzahl of radiographic phases (74) and

for comparing the actually determined

Ranges with the simulated setpoints.

27. Irradiation plant according to one of claims 16 to 26, comprising a computing device, formed:

to perform a range simulation calculation for a plurality of

Halftone dots to form a multi-dimensional simulated setpoint map (DRRM) of the ion beam range after passing through the target volume in the ion beam

Radiographic Phase (74) to create

for determining the actual ranges of the ion beam after passing through the target volume (12) for a multiplicity of raster points and for

Creation of a multidimensional ionic radiogram with the respective actual ranges of the

Ion beam and

to compare the ionic radiogram with the simulated set point map. 28. Irradiation system according to one of claims 16 to 27, wherein an internal or external movement measuring system (54) for measuring the movement of the target volume or a movement surrogate is included, and the

Control device (39) is formed:

Record measurement results of the motion measurement system (54),

To record ionic radiograms of the ionic radiography detector (20),

automatically the measurement results and the

To combine ionic radiograms and to control the irradiation in response to the linked data.

Irradiation system according to one of claims 16 to 28, wherein an internal or external movement measuring system (54) for measuring the movement of the target volume or a movement surrogate is included, and the

Control device (39) is formed:

the change between the radiographic phases (74) and the deposition phases (76) in response to the

Measurement results of the motion measuring system (54) too

Taxes .

Irradiation plant according to one of claims 16 to 29, wherein the irradiation facility (1) is designed to be the target volume (12) in the at least one or the

Irradiate a plurality of radiographic phases (74) from more than one direction to thereby acquire at least one spatially more than two-dimensional ionic radiogram.