EP2807087A1 - Flexibler flüssigkeitsbehälter und zugehörige verfahren - Google Patents
Flexibler flüssigkeitsbehälter und zugehörige verfahrenInfo
- Publication number
- EP2807087A1 EP2807087A1 EP13741235.9A EP13741235A EP2807087A1 EP 2807087 A1 EP2807087 A1 EP 2807087A1 EP 13741235 A EP13741235 A EP 13741235A EP 2807087 A1 EP2807087 A1 EP 2807087A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- vessel
- bottom wall
- generally
- fluid
- panels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D88/00—Large containers
- B65D88/26—Hoppers, i.e. containers having funnel-shaped discharge sections
- B65D88/28—Construction or shape of discharge section
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/06—Liquids or semi-liquids or other materials or articles enclosed in flexible containers disposed within rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D90/00—Component parts, details or accessories for large containers
- B65D90/02—Wall construction
- B65D90/04—Linings
- B65D90/046—Flexible liners, e.g. loosely positioned in the container
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Definitions
- This disclosure relates generally to the fluid handling arts and, more particularly, to a flexible fluid vessel and related methods.
- vessels or bags for at least temporarily receiving and containing the fluid.
- hermetically sealed bags formed of flexible plastic film are often used for bulk intermediate storage, cell culture re- suspension, viral inactivation, final formulation, final fill, or as bioreactors.
- such vessels or bags generally come in two shapes, cylindrical and cubical, typically have a flat bottom, and universally require some form of external support structure, such as a rigid outer tank, during use.
- FIG. 1-3 schematically depict a cubic bag B in an outer tank K. Aside from lacking aesthetic appeal, this separation results in gaps G and folds F or creases in the flexible walls, which can not only impair the flow of fluid within the bag B and create crevasses where debris can become trapped, but also tend to stress the material and increase the chance of deleterious perforation.
- Such flat-bottomed vessels when used with a mixer M positioned along the floor also generally require a significant minimum amount of fluid to be present in order for the mixer to become submerged prior to commencing the mixing operation. Draining the fluid from a flat-bottomed vessel may also pose an issue, since the flat floor does not in any way help to guide the fluid toward a stationary floor drain, regardless of its relative positioning.
- a need is identified for a manner of providing an improved flexible vessel, such as a mixing bag.
- the vessel would be capable of use in addressing a variety of different requirements for fluid processing operations, including the proper seating of the vessel in any outside tank or like support structure, mixing with less fluid that would be required with a flat-bottomed vessel, and improved draining of the fluid.
- the vessel would also be relatively easy to create and implement. Overall, use of the improved vessel would thus lead to a simplification of the fluid processing and a concomitant reduction in the expense associated with such use.
- an apparatus for receiving a fluid comprises an at least partially flexible vessel including a top wall and a plurality of sidewalls.
- a first of the sidewalls includes a first length in a first plane that is greater than a second length of the second, generally orthogonal sidewall in the first plane, and a bottom wall depending from the at least two sidewalls.
- the vessel may thus be rectangular in cross-section and, in particular, may have a generally continuous rectangular cross-section from the top wall to the bottom wall.
- the area of the cross-section may instead generally decrease continuously from a lowermost portion of the sidewalls to a vertex of the bottom wall.
- the bottom wall of the vessel is flexible, but it may be fully or partially rigid instead.
- the bottom wall may comprise at least two generally triangular panels.
- the bottom wall may comprise at least two generally trapezoidal panels.
- the bottom wall may also comprise at least four generally triangular panels or at least four generally trapezoidal panels.
- the bottom wall may comprise a central region including a generally flat upper surface, which may be formed by a rigid portion.
- the rigid portion may include at least one port.
- the rigid portion may be at least partially transparent.
- the vessel may include a bottom weld for connecting at least part of the bottom wall to at least one of the sidewalls.
- the bottom weld may form an angle of less than 45 degrees relative to the sidewall in at least a folded state.
- the vessel may include a bottom K weld that is less than 45 degrees, and a top K-weld that is 45 degrees or more. More generally, the vessel may include a top K weld having an angle that is greater than the angle of the bottom weld.
- the vessel in a folded position may also include a side comprising a first length of a bottom portion, an intermediate portion having a second length, and a third length of a top portion, wherein the first length is greater than the third length.
- the apparatus comprises an at least partially flexible vessel including an upper portion having a generally rectangular body and a generally tapered portion depending therefrom.
- Still a further aspect of this disclosure pertains to an apparatus for receiving a fluid.
- the apparatus comprises a vessel having at least one sidewall and a bottom wall having a non-circular shape.
- the sidewall may be flexible and the bottom wall may be rigid.
- Yet another aspect of the disclosure pertains to an apparatus for receiving a fluid, comprising a vessel having at least one flexible sidewall and a rigid bottom wall having at least two generally triangular panels.
- the bottom wall may include at least two generally trapezoidal panels and possibly four generally triangular panels.
- the disclosure also pertains to an apparatus for receiving a fluid, comprising a vessel having at least one flexible sidewall and a rigid bottom wall having at least four trapezoidal panels.
- a further aspect of this disclosure is an apparatus for receiving a fluid, comprising a bag having a bottom K weld that is less than 45 degrees.
- the bottom K weld may be between about 40 and about 44 degrees.
- the bottom K weld may be about 41 degrees.
- This disclosure also relates to an apparatus for receiving a fluid, comprising a vessel in the form of a bag having a top K weld with an angle, ⁇ , and a bottom K weld with an angle, ⁇ , wherein ⁇ > ⁇ .
- Another aspect of the present disclosure pertains to an apparatus for receiving a fluid, comprising a bag that in an inflated condition forms a generally rectangular structure, and in a folded condition includes a side having a dimension defined by a first portion T, a second portion B, and an intermediate portion I between the first and second portions, wherein T ⁇ B.
- Any apparatus described herein may further include a support structure for receiving the vessel.
- the support structure may comprise an interior matching the contour of at least a lower portion of the vessel.
- the vessel may further include a mixer, a sparger, a sensor, a drain, or any combination of the foregoing.
- the apparatus comprises a vessel including an at least partially flexible body having a depending portion comprising a plurality of first panels; and a support structure comprising a floor having a surface corresponding to each of the plurality of first panels.
- This disclosure also has as one of any objects the provision of a collapsible mixing vessel including four generally planar and vertically extending side panels and a sloped floor. At least two of the side panels may be generally rectangular, and at least one of the side panels may be generally square.
- a collapsible mixing vessel comprising a flexible upper portion connected to at least two sloping panels forming a floor also forms a part of this disclosure.
- the floor may be at least partially rigid.
- This disclosure also pertains to processes, such as a method of forming a vessel for receiving a fluid.
- the method comprises forming a depending portion of the vessel by connecting a first panel of film adapted to form a bottom of the vessel to a second panel of film also adapted to form the bottom of the vessel at an angle of less than 45 degrees.
- Another aspect of the disclosure relates to a method of forming a vessel for receiving a fluid, comprising connecting a plurality of panels of film to provide the vessel with an upper portion comprising a non-circular body having a generally tapered depending portion.
- a method of processing a fluid may comprise placing the disclosed vessel in a tank including a floor having a contour matching the shape of the bottom wall.
- Figures 1-3 are photographs illustrating one problem to be addressed by the disclosure.
- Figures 4-6 provide various views of fluid vessels according to the disclosure.
- FIGS 7 and 8 illustrate further views of fluid vessels.
- FIG. 4-5 illustrate a vessel 10 for receiving a fluid, such as for processing.
- the vessel 10 includes a bottom wall 12, a plurality of sidewalls 14, and a top wall 16. These structures combine to form a generally rectangular body having a first dimension, such as the length L, greater than a second, generally orthogonal dimension, such as the width W, in a common plane, such as a horizontal plane P coextensive with the lower terminus of the sidewalls 14.
- At least one of the components of the vessel 10 may be flexible, such as for example the sidewalls 14.
- all of the walls 12, 14, 16 are flexible.
- the vessel 10 takes the form of a flexible bag (but for purposes of this disclosure, the term bag may cover a vessel with one or more rigid walls or rigid portions as well). Consequently, the vessel 10 may collapse when not filled with the fluid.
- the bottom wall 12 of the vessel 10 is arranged to form a depending portion.
- the bottom wall 12 may depend from the plane P and generally taper in a direction toward an axis extending through the center of the vessel but away from the major plane of the corresponding side wall 14. Consequently, the bottom wall 12 forms the depending portion generally in the shape of a polyhedron (if the portion associated with plane P were a solid surface).
- this polyhedron is generally an inverted pyramid, which includes four sides or panels, with two sides 12a, and 12b generally forming triangles, and two sides 12c and 12d generally forming trapezoids.
- the result at the interface between the four ends of the panels 12a-12d is a seam 18 extending in the longitudinal direction L, and defining a vertex essentially located at a central region 22 on the bottom of the vessel 10.
- this seam 18 may dictate that any port, such as for a drain, inlet, sensor, probe, or the like, should be provided at an offset or non-centered location along the sloping floor formed by the bottom wall 12.
- any port such as for a drain, inlet, sensor, probe, or the like
- one or more openings 20 may be provided on bottom side panel 12d, as well as on the opposite panel 12c.
- the opening 20 when serving as a drain should be positioned as close to the vertex defined by seam 18 as possible, thus ensuring that the sloping panels 12a- 12d of the bottom wall 12 help to maximize the volume of fluid that flows through the drain when emptying of the vessel 10 is desired.
- FIG. 5 shows an exemplary vessel 10 made according to the disclosure in a folded or flat condition, such as is usually the result just after manufacturing and prior to use (normally after inflation with a fluid). Fabrication of the vessel 10 generally requires securely connecting together multiple panels of film, such as by welding, adhesive, or the like. The film panels are sized and shaped so as to provide the resulting vessel 10 with the generally rectangular shape in cross-section when inflated.
- connection among the film panels is made by welding, including along the portions of film that ultimately form the portions of the vessel 10 including the bottom wall 12 and the top wall 16.
- These welds typically referred to as "K welds” are placed such that they are at an angle, ⁇ , relative to an axis associated with the longitudinal dimension of the sidewall 14, which angle is less than 45 degrees (which may be considered a "K weld” of less than 45 degrees).
- the angle is between 40-45 degrees, and may be more specifically 41 degrees.
- the angles of the K welds on the opposite sides of the bottom of the folded vessel 10 may be equal or unequal, depending on the desired configuration.
- Similar K welds may be provided for forming the top of the vessel 10.
- the angle, ⁇ , of one or both of the top K welds may be greater than that of the bottom welds.
- the angle ⁇ of the top welds may be 45 degrees or greater.
- the top welds may be the same for each side of the vessel 10, or may be different, depending on the situation.
- the resulting vessel 10 when folded includes a side with a total length H that can be defined as an intermediate portion I plus a top length T and a bottom length B, where B>T.
- a total length H that can be defined as an intermediate portion I plus a top length T and a bottom length B, where B>T.
- a similarly shaped support structure such as a tank 24 having an interior surface generally corresponding to the shape of the vessel 10, as shown in cross-section in Figure 7 (and with the understanding that the floor of the tank 24 may include one or more openings for receiving drive units, tubing, port fitments, etc.)
- the tendency of the sidewalls 14 to slouch or peel away from the corresponding walls of the tank 24 may be eliminated, or at least reduced considerably. Consequently, the incidence of undesirable folds is likewise kept in check and a more tidy arrangement is presented.
- matching the contour of the floor of the tank 24 with the welds along the bottom portion of the vessel 10 may also help to reduce stress.
- the non-circular shape of the interior compartment also may avoid the creation of the usually undesirable vortices in the fluid that may result from agitation using a mixer or the like, especially when located in the center of the vessel.
- Figure 8 illustrates that the bottom wall 12 of the vessel 10 may also comprise a rigid material 26.
- a rigid material 26 may be instead of or in addition to a piece of film also forming all or a portion of the bottom wall 12, but one approach may be for the rigid material 26 to connect directly to the sidewalls 14, such as by welding (and perhaps with overlapping to help ensure the seal is formed in the desired manner).
- the material 26 may be formed having a polyhedral shape, such as a pyramid as described above with respect to the bottom wall 12 formed of the flexible film.
- Figures 9 and 10 illustrate a further embodiment in which the rigid or flexible bottom wall 12 of the vessel 10 forms a depending portion, as with the other embodiments described herein.
- the central region 22 formed by the concurrence of the panels 12a-12d forming the bottom wall 12 is oversized as compared to the Figure 4 embodiment, and may take the shape of a rectangle in top plan view ( Figure 10).
- the bottom wall 12 is formed of four generally trapezoidal panels 12a-12d in this embodiment.
- This central region 22 may thus receive or support any hardware, such as a drain, mixer, sparger, sensor or the like.
- Figure 11 indicates that the center region 22 may comprise, in whole or in part, a generally flat wall, such as formed by a rigid plate 28.
- This plate 28 may also be at least partially transparent, such as for allowing light to pass for contacting an optical sensor in contact with the fluid in the vessel, or allowing for observations, such as through an external microscope or like device.
- Various ports 20 may also be provided in the plate 28 for drains, supports for mixers, gas input, or the like.
- the entire bottom wall 12 may take the form of a rigid cup- shaped structure to which the film forming the sidewalls 14 is attached.
- the vessel 10 In use, the vessel 10, especially when in the form of a flexible bag, is generally sealed for use under sterile conditions. Any ports through which additions are made to the interior compartments may include sterile connectors or filters to help ensure the sterile conditions.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261591091P | 2012-01-26 | 2012-01-26 | |
PCT/US2013/023328 WO2013112963A1 (en) | 2012-01-26 | 2013-01-26 | Flexible fluid vessel and related methods |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2807087A1 true EP2807087A1 (de) | 2014-12-03 |
Family
ID=48873986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13741235.9A Withdrawn EP2807087A1 (de) | 2012-01-26 | 2013-01-26 | Flexibler flüssigkeitsbehälter und zugehörige verfahren |
Country Status (3)
Country | Link |
---|---|
US (1) | US20150008234A1 (de) |
EP (1) | EP2807087A1 (de) |
WO (1) | WO2013112963A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6797417B2 (ja) | 2015-04-16 | 2020-12-09 | グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー | バイオプロセスミキサー |
US10575067B2 (en) * | 2017-01-04 | 2020-02-25 | Samsung Electronics Co., Ltd. | Context based augmented advertisement |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL90586A (en) * | 1988-06-15 | 1995-10-31 | May & Baker Ltd | Package releases software by touching with water |
US5148939A (en) * | 1989-02-25 | 1992-09-22 | Soltralentz S.A. | Container for storing and transporting a liquid |
JP2915342B2 (ja) * | 1996-03-06 | 1999-07-05 | 日新産商株式会社 | コンテナ用容器 |
CN1222839C (zh) * | 2000-01-07 | 2005-10-12 | 株式会社理光 | 粉体收纳容器,粉体排出装置及图像形成装置 |
JP4450606B2 (ja) * | 2003-11-19 | 2010-04-14 | 藤森工業株式会社 | 包装容器 |
-
2013
- 2013-01-26 WO PCT/US2013/023328 patent/WO2013112963A1/en active Application Filing
- 2013-01-26 EP EP13741235.9A patent/EP2807087A1/de not_active Withdrawn
- 2013-01-26 US US14/374,952 patent/US20150008234A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO2013112963A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2013112963A1 (en) | 2013-08-01 |
US20150008234A1 (en) | 2015-01-08 |
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Legal Events
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Effective date: 20140822 |
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DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
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18W | Application withdrawn |
Effective date: 20150731 |