EP2777804A3 - Apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial - Google Patents

Apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial Download PDF

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Publication number
EP2777804A3
EP2777804A3 EP20140159987 EP14159987A EP2777804A3 EP 2777804 A3 EP2777804 A3 EP 2777804A3 EP 20140159987 EP20140159987 EP 20140159987 EP 14159987 A EP14159987 A EP 14159987A EP 2777804 A3 EP2777804 A3 EP 2777804A3
Authority
EP
European Patent Office
Prior art keywords
particulate
biomaterial
port
liquid
hydrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20140159987
Other languages
German (de)
French (fr)
Other versions
EP2777804A2 (en
Inventor
Benjamin B Anderson
Kevin C Geppert
Thomas A Kirk
Lou Huadong
Mark Stevenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordson Corp
Original Assignee
Nordson Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordson Corp filed Critical Nordson Corp
Priority to EP15169618.4A priority Critical patent/EP2937135B1/en
Publication of EP2777804A2 publication Critical patent/EP2777804A2/en
Publication of EP2777804A3 publication Critical patent/EP2777804A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8827—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it with filtering, degassing, venting or pressure relief means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/223—Multiway valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/51—Methods thereof
    • B01F23/511—Methods thereof characterised by the composition of the liquids or solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/54—Mixing liquids with solids wetting solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/70—Pre-treatment of the materials to be mixed
    • B01F23/703—Degassing or de-aerating materials; Replacing one gas within the materials by another gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A61J1/2062—Connecting means having multiple connecting ports with directional valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M2039/229—Stopcocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/20—Mixing of ingredients for bone cement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2202—Mixing compositions or mixers in the medical or veterinary field

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Prostheses (AREA)
  • Jet Pumps And Other Pumps (AREA)

Abstract

An apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial includes a vacuum device 18 and a valve 16 for withdrawing a gas from the particulate biomaterial and introducing the liquid biomaterial. The valve 16 includes a hub 26, a valve body 24, a particulate port 27, a vacuum port 30, and a liquid port 28. The valve body selectively moves between first and second positions. The valve body at least partially defines a first passage 65 and a second passage 88. The particulate port, the vacuum port, and the liquid port are each configured to fluidly connect to a particulate container 20, the vacuum device 18, and the liquid container 22, respectively. In the first position, the first passage 65 fluidly connects the vacuum port 30 to the particulate port 27 for withdrawing the gas from the particulate container 20. In the second position, the second passage 88 fluidly connects the liquid port 28 to the particulate port 27 for hydrating the particulate biomaterial.
EP20140159987 2013-03-15 2014-03-14 Apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial Withdrawn EP2777804A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15169618.4A EP2937135B1 (en) 2013-03-15 2014-03-14 Apparatus for hydrating a particulate biomaterial with a liquid biomaterial

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361794743P 2013-03-15 2013-03-15
US14/206,586 US9592321B2 (en) 2013-03-15 2014-03-12 Apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP15169618.4A Division EP2937135B1 (en) 2013-03-15 2014-03-14 Apparatus for hydrating a particulate biomaterial with a liquid biomaterial

Publications (2)

Publication Number Publication Date
EP2777804A2 EP2777804A2 (en) 2014-09-17
EP2777804A3 true EP2777804A3 (en) 2014-12-03

Family

ID=50345855

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20140159987 Withdrawn EP2777804A3 (en) 2013-03-15 2014-03-14 Apparatus and method for hydrating a particulate biomaterial with a liquid biomaterial
EP15169618.4A Not-in-force EP2937135B1 (en) 2013-03-15 2014-03-14 Apparatus for hydrating a particulate biomaterial with a liquid biomaterial

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP15169618.4A Not-in-force EP2937135B1 (en) 2013-03-15 2014-03-14 Apparatus for hydrating a particulate biomaterial with a liquid biomaterial

Country Status (4)

Country Link
US (2) US9592321B2 (en)
EP (2) EP2777804A3 (en)
CA (1) CA2846714A1 (en)
ES (1) ES2664087T3 (en)

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ES2675125T3 (en) * 2011-07-20 2018-07-06 Stryker Corporation Manifold to fill a plurality of cannulas
US9604184B2 (en) 2013-03-06 2017-03-28 Orthovita, Inc. Mixing system and valve assembly
EP3060131B1 (en) * 2013-10-21 2019-12-11 Accuro Technologies Inc. Double barrel syringe and method to use same for placement confirmation and joint space injection
WO2016168806A1 (en) * 2015-04-16 2016-10-20 Becton Dickinson and Company Limited Fluid transfer device
WO2016193693A2 (en) * 2015-05-29 2016-12-08 Medical Device Creations Limited Medical connector
CA3019843C (en) 2016-04-22 2023-08-01 Accuro Technologies Inc. Single slider double barrel syringe and method to use same for medical diagnostics, therapeutic use, and placement confirmation and joint space injection
US10231846B2 (en) 2016-08-19 2019-03-19 Stryker European Holdings I, Llc Bone graft delivery loading assembly
AU2019294392A1 (en) * 2018-06-27 2021-01-07 Ferrosan Medical Devices A/S Device for forming a medical paste
CN112449606A (en) * 2018-06-27 2021-03-05 弗罗桑医疗设备公司 Device for mixing medical pastes
US10813676B2 (en) * 2018-08-29 2020-10-27 Warsaw Orthopedic, Inc. Bone material hydration devices and methods
CN110813115B (en) * 2019-10-23 2020-11-24 齐鲁工业大学 Homogenizing valve for high-pressure homogenizer
WO2021154592A1 (en) * 2020-01-27 2021-08-05 Becton, Dickinson And Company Syringe actuated stopcock smart-valve
GB2595846A (en) * 2020-05-28 2021-12-15 Overx Medical Ltd An adapter Apparatus
WO2022137182A1 (en) * 2020-12-23 2022-06-30 Tolmar International Limited Systems and methods for mixing syringe valve assemblies
CH719387A1 (en) 2022-01-26 2023-07-31 Silberspross Gmbh Medical fluid control device.
WO2024003329A1 (en) * 2022-06-30 2024-01-04 Eveon Mobile carriage unit

Citations (4)

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Publication number Priority date Publication date Assignee Title
US20010016703A1 (en) * 1999-12-29 2001-08-23 John Wironen System for reconstituting pastes and methods of using same
US20020017328A1 (en) * 1998-01-08 2002-02-14 George Loo Stopcock having axial port for syringe twist actuation
EP1627658A1 (en) * 2004-08-16 2006-02-22 SIS-TER S.p.A. Two-way T-like valve for an infusion line
US20120071884A1 (en) * 2010-09-01 2012-03-22 Biocomposites Limited Mixing and dispensing apparatus for bone void filler

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US4423741A (en) 1980-01-14 1984-01-03 Plasco, Inc. Midstream sampling of catheterized liquid flow from a body cavity and improved coupling therefor
IT1244370B (en) 1991-01-11 1994-07-08 Roerig Farmaceutici Italiana S DEVICE FOR THE SELECTIVE COLLECTION OF BLOOD SAMPLES FROM TWO SECTIONS OF A LINE AND BY INJECTION OF DRUGS INTO THE BLOOD ITSELF
CA2432871A1 (en) * 2003-05-23 2004-11-23 Pathfinder Systems, Inc. Distributed control architecture and improved metering apparatus and methods for agricultural chemical dispensers
US7637279B2 (en) 2006-01-20 2009-12-29 Smiths Medical Asd, Inc. Shuttle valve
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US9604184B2 (en) * 2013-03-06 2017-03-28 Orthovita, Inc. Mixing system and valve assembly

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020017328A1 (en) * 1998-01-08 2002-02-14 George Loo Stopcock having axial port for syringe twist actuation
US20010016703A1 (en) * 1999-12-29 2001-08-23 John Wironen System for reconstituting pastes and methods of using same
EP1627658A1 (en) * 2004-08-16 2006-02-22 SIS-TER S.p.A. Two-way T-like valve for an infusion line
US20120071884A1 (en) * 2010-09-01 2012-03-22 Biocomposites Limited Mixing and dispensing apparatus for bone void filler

Also Published As

Publication number Publication date
US20140261082A1 (en) 2014-09-18
CA2846714A1 (en) 2014-09-15
US9592321B2 (en) 2017-03-14
US9925305B2 (en) 2018-03-27
EP2937135A1 (en) 2015-10-28
EP2777804A2 (en) 2014-09-17
US20170136151A1 (en) 2017-05-18
EP2937135B1 (en) 2018-02-07
ES2664087T3 (en) 2018-04-18

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